List of canonical signaling pathways in the proximal nerve...

List of canonical signaling pathways in the proximal nerve stumps at 0.5 h, 1 h, 3 h, 6 h, 9 h, 1 d, 4 d, 7 d,

and 14 d after nerve injury 0.5 hour

Ingenuity Canonical Pathways −log(P value) Ratio z-score Molecules Airway Pathology in Chronic Obstructive Pulmonary Disease

4.14E+00 2.50E-01 NaN CXCL3, MMP8

Retinoate Biosynthesis I 2.85E+00 5.88E-02 NaN Akr1b10, DHRS7C Inhibition of Matrix Metalloproteases 2.73E+00 5.13E-02 NaN MMP8, A2M

Synaptic Long Term Depression 2.54E+00 1.72E-02 NaN ABHD3, Gucy2d, PPP2R5E

Hepatic Fibrosis / Hepatic Stellate Cell Activation 2.45E+00 1.60E-02 NaN CXCL3, IL6, A2M PXR/RXR Activation 2.29E+00 3.08E-02 NaN GSTA1, IL6 TREM1 Signaling 2.17E+00 2.67E-02 NaN CXCL3, IL6 Dopamine Receptor Signaling 2.15E+00 2.60E-02 NaN ADCY2, PPP2R5E IL-17A Signaling in Airway Cells 2.14E+00 2.56E-02 NaN CXCL3, IL6 Colorectal Cancer Metastasis Signaling 2.11E+00 1.21E-02 NaN ADCY2, MMP8, IL6 Glycoaminoglycan-protein Linkage Region Biosynthesis

1.94E+00 1.43E-01 NaN B3GAT1

CDK5 Signaling 1.94E+00 2.02E-02 NaN ADCY2, PPP2R5E Xenobiotic Metabolism Signaling 1.92E+00 1.03E-02 NaN GSTA1, IL6, PPP2R5E Glucocorticoid Receptor Signaling 1.74E+00 8.85E-03 NaN CXCL3, IL6, A2M Atherosclerosis Signaling 1.73E+00 1.57E-02 NaN ABHD3, IL6 IL-6 Signaling 1.73E+00 1.56E-02 NaN IL6, A2M Role of IL-17A in Psoriasis 1.67E+00 7.69E-02 NaN CXCL3 Corticotropin Releasing Hormone Signaling 1.66E+00 1.44E-02 NaN ADCY2, Gucy2d

Cardiac β-adrenergic Signaling 1.65E+00 1.43E-02 NaN ADCY2, PPP2R5E Aryl Hydrocarbon Receptor Signaling 1.65E+00 1.42E-02 NaN GSTA1, IL6 Relaxin Signaling 1.56E+00 1.27E-02 NaN ADCY2, Gucy2d Hepatic Cholestasis 1.55E+00 1.25E-02 NaN ADCY2, IL6 Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F

1.53E+00 5.56E-02 NaN IL6

Dopamine-DARPP32 Feedback in cAMP Signaling 1.53E+00 1.22E-02 NaN ADCY2, PPP2R5E Methylglyoxal Degradation III 1.51E+00 5.26E-02 NaN Akr1b10 Histamine Degradation 1.51E+00 5.26E-02 NaN HNMT Acute Phase Response Signaling 1.50E+00 1.18E-02 NaN IL6, A2M The Visual Cycle 1.49E+00 5.00E-02 NaN Akr1b10 Granulocyte Adhesion and Diapedesis 1.46E+00 1.12E-02 NaN CXCL3, MMP8 PPARα/RXRα Activation 1.45E+00 1.11E-02 NaN ADCY2, IL6 Glutathione Redox Reactions I 1.41E+00 4.17E-02 NaN GSTA1 RAR Activation 1.41E+00 1.05E-02 NaN ADCY2, DHRS7C Endothelin-1 Signaling 1.41E+00 1.05E-02 NaN ADCY2, ABHD3 Agranulocyte Adhesion and Diapedesis 1.41E+00 1.05E-02 NaN CXCL3, MMP8 Role of JAK family kinases in IL-6-type Cytokine Signaling

1.39E+00 4.00E-02 NaN IL6

Gap Junction Signaling 1.39E+00 1.03E-02 NaN ADCY2, Gucy2d Breast Cancer Regulation by Stathmin1 1.35E+00 9.76E-03 NaN ADCY2, PPP2R5E IL-15 Production 1.35E+00 3.57E-02 NaN IL6 Glutathione-mediated Detoxification 1.30E+00 3.23E-02 NaN GSTA1 Role of NFAT in Cardiac Hypertrophy 1.30E+00 9.13E-03 NaN ADCY2, IL6

Coagulation System 1.25E+00 2.86E-02 NaN A2M IL-17A Signaling in Fibroblasts 1.25E+00 2.86E-02 NaN IL6 Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis

1.25E+00 8.58E-03 NaN MMP8, IL6

Cardiac Hypertrophy Signaling 1.24E+00 8.47E-03 NaN ADCY2, IL6 Cell Cycle Regulation by BTG Family Proteins 1.23E+00 2.70E-02 NaN PPP2R5E Complement System 1.23E+00 2.70E-02 NaN CFI Opioid Signaling Pathway 1.22E+00 8.26E-03 NaN RGS9, ADCY2 Retinol Biosynthesis 1.17E+00 2.38E-02 NaN Akr1b10 Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza

1.16E+00 2.33E-02 NaN IL6

Serotonin Receptor Signaling 1.16E+00 2.33E-02 NaN ADCY2 Role of IL-17F in Allergic Inflammatory Airway Diseases

1.15E+00 2.22E-02 NaN IL6

Hematopoiesis from Pluripotent Stem Cells 1.13E+00 2.13E-02 NaN IL6 Graft-versus-Host Disease Signaling 1.12E+00 2.08E-02 NaN IL6 Phototransduction Pathway 1.08E+00 1.89E-02 NaN RGS9 Role of Cytokines in Mediating Communication between Immune Cells

1.07E+00 1.85E-02 NaN IL6

Role of CHK Proteins in Cell Cycle Checkpoint Control

1.05E+00 1.75E-02 NaN PPP2R5E

Chondroitin Sulfate Biosynthesis 1.05E+00 1.75E-02 NaN B3GAT1 Dermatan Sulfate Biosynthesis 1.03E+00 1.69E-02 NaN B3GAT1 Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis

1.03E+00 6.41E-03 NaN PRSS2, IL6

Phospholipases 1.01E+00 1.61E-02 NaN ABHD3 Activation of IRF by Cytosolic Pattern Recognition Receptors

1.01E+00 1.59E-02 NaN IL6

Mitotic Roles of Polo-Like Kinase 9.87E-01 1.52E-02 NaN PPP2R5E Eicosanoid Signaling 9.80E-01 1.49E-02 NaN ABHD3 IL-10 Signaling 9.68E-01 1.45E-02 NaN IL6 Role of IL-17A in Arthritis 9.68E-01 1.45E-02 NaN CXCL3 Role of MAPK Signaling in the Pathogenesis of Influenza

9.51E-01 1.39E-02 NaN ABHD3

T Helper Cell Differentiation 9.45E-01 1.37E-02 NaN IL6 GPCR-Mediated Integration of Enteroendocrine Signaling Exemplified by an L Cell

9.45E-01 1.37E-02 NaN ADCY2

IL-15 Signaling 9.29E-01 1.32E-02 NaN IL6 Antiproliferative Role of Somatostatin Receptor 2 9.29E-01 1.32E-02 NaN Gucy2d Cyclins and Cell Cycle Regulation 9.08E-01 1.25E-02 NaN PPP2R5E Heparan Sulfate Biosynthesis 8.98E-01 1.22E-02 NaN B3GAT1 JAK/Stat Signaling 8.93E-01 1.20E-02 NaN IL6 IL-17 Signaling 8.83E-01 1.18E-02 NaN IL6 Growth Hormone Signaling 8.83E-01 1.18E-02 NaN A2M Leptin Signaling in Obesity 8.79E-01 1.16E-02 NaN ADCY2 α-Adrenergic Signaling 8.74E-01 1.15E-02 NaN ADCY2 HIPPO signaling 8.74E-01 1.15E-02 NaN PPP2R5E Bladder Cancer Signaling 8.69E-01 1.14E-02 NaN MMP8 Crosstalk between Dendritic Cells and Natural Killer Cells

8.65E-01 1.12E-02 NaN IL6

Altered T Cell and B Cell Signaling in Rheumatoid Arthritis

8.60E-01 1.11E-02 NaN IL6

IL-1 Signaling 8.51E-01 1.09E-02 NaN ADCY2 Ceramide Signaling 8.47E-01 1.08E-02 NaN PPP2R5E Communication between Innate and Adaptive Immune Cells

8.43E-01 1.06E-02 NaN IL6

GABA Receptor Signaling 8.38E-01 1.05E-02 NaN ADCY2 Melanocyte Development and Pigmentation Signaling 8.26E-01 1.02E-02 NaN ADCY2 ATM Signaling 8.26E-01 1.02E-02 NaN PPP2R5E CTLA4 Signaling in Cytotoxic T Lymphocytes 8.22E-01 1.01E-02 NaN PPP2R5E Antioxidant Action of Vitamin C 7.87E-01 9.26E-03 NaN ABHD3 Gαs Signaling 7.80E-01 9.09E-03 NaN ADCY2 Telomerase Signaling 7.76E-01 9.01E-03 NaN PPP2R5E GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells

7.73E-01 8.93E-03 NaN ADCY2

G Beta Gamma Signaling 7.66E-01 8.77E-03 NaN ADCY2 HGF Signaling 7.62E-01 8.70E-03 NaN IL6 HIF1α Signaling 7.52E-01 8.47E-03 NaN MMP8 Neuroprotective Role of THOP1 in Alzheimer's Disease

7.49E-01 8.40E-03 NaN PRSS2

Gαi Signaling 7.45E-01 8.33E-03 NaN ADCY2 LXR/RXR Activation 7.42E-01 8.26E-03 NaN IL6 Renin-Angiotensin Signaling 7.39E-01 8.20E-03 NaN ADCY2 Sphingosine-1-phosphate Signaling 7.29E-01 8.00E-03 NaN ADCY2 PI3K/AKT Signaling 7.29E-01 8.00E-03 NaN PPP2R5E

Sperm Motility 7.23E-01 7.87E-03 NaN ABHD3 Cellular Effects of Sildenafil (Viagra) 7.11E-01 7.63E-03 NaN ADCY2 p70S6K Signaling 7.08E-01 7.58E-03 NaN PPP2R5E HMGB1 Signaling 7.05E-01 7.52E-03 NaN IL6 P2Y Purigenic Receptor Signaling Pathway 7.02E-01 7.46E-03 NaN ADCY2 Th1 Pathway 6.99E-01 7.41E-03 NaN IL6 Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses

6.94E-01 7.30E-03 NaN IL6

D-myo-inositol (1, 4, 5, 6)-Tetrakisphosphate Biosynthesis

6.74E-01 6.94E-03 NaN PPP2R5E

D-myo-inositol (3, 4, 5, 6)-tetrakisphosphate Biosynthesis

6.74E-01 6.94E-03 NaN PPP2R5E

Gustation Pathway 6.51E-01 6.54E-03 NaN ADCY2 Regulation of eIF4 and p70S6K Signaling 6.41E-01 6.37E-03 NaN PPP2R5E 3-phosphoinositide Degradation 6.39E-01 6.33E-03 NaN PPP2R5E D-myo-inositol-5-phosphate Metabolism 6.29E-01 6.17E-03 NaN PPP2R5E CXCR4 Signaling 6.22E-01 6.06E-03 NaN ADCY2 GNRH Signaling 6.22E-01 6.06E-03 NaN ADCY2 Tight Junction Signaling 6.18E-01 5.99E-03 NaN PPP2R5E eNOS Signaling 6.06E-01 5.81E-03 NaN ADCY2 Wnt/β-catenin Signaling 6.06E-01 5.81E-03 NaN PPP2R5E Germ Cell-Sertoli Cell Junction Signaling 6.04E-01 5.78E-03 NaN A2M Sertoli Cell-Sertoli Cell Junction Signaling 5.94E-01 5.62E-03 NaN A2M Th1 and Th2 Activation Pathway 5.79E-01 5.41E-03 NaN IL6 NRF2-mediated Oxidative Stress Response 5.63E-01 5.18E-03 NaN GSTA1

Dendritic Cell Maturation 5.63E-01 5.18E-03 NaN IL6 Production of Nitric Oxide and Reactive Oxygen Species in Macrophages

5.62E-01 5.15E-03 NaN PPP2R5E

ILK Signaling 5.56E-01 5.08E-03 NaN PPP2R5E 3-phosphoinositide Biosynthesis 5.50E-01 5.00E-03 NaN PPP2R5E ERK/MAPK Signaling 5.50E-01 5.00E-03 NaN PPP2R5E mTOR Signaling 5.48E-01 4.98E-03 NaN PPP2R5E Thrombin Signaling 5.43E-01 4.90E-03 NaN ADCY2 Leukocyte Extravasation Signaling 5.31E-01 4.74E-03 NaN MMP8 CREB Signaling in Neurons 5.29E-01 4.72E-03 NaN ADCY2 AMPK Signaling 5.22E-01 4.63E-03 NaN PPP2R5E LPS/IL-1 Mediated Inhibition of RXR Function 5.12E-01 4.50E-03 NaN GSTA1 Systemic Lupus Erythematosus Signaling 5.07E-01 4.44E-03 NaN IL6 cAMP-mediated signaling 5.04E-01 4.41E-03 NaN ADCY2 Superpathway of Inositol Phosphate Compounds 4.92E-01 4.26E-03 NaN PPP2R5E Phospholipase C Signaling 4.83E-01 4.15E-03 NaN ADCY2 G-Protein Coupled Receptor Signaling 4.35E-01 3.62E-03 NaN ADCY2 Neuroinflammation Signaling Pathway 3.95E-01 3.22E-03 NaN IL6 Molecular Mechanisms of Cancer 3.18E-01 2.54E-03 NaN ADCY2 Protein Kinase A Signaling 3.14E-01 2.50E-03 NaN ADCY2 Axonal Guidance Signaling 2.77E-01 2.21E-03 NaN MMP8

1 hour Ingenuity Canonical Pathways −log(P value) Ratio z-score Molecules

Agranulocyte Adhesion and Diapedesis 4.55E+00 2.62E-02 NaN CXCL3, CXCL13, CCL20, MMP12, ACTC1

Role of IL-17A in Psoriasis 3.58E+00 1.54E-01 NaN CXCL3, CCL20 Granulocyte Adhesion and Diapedesis 3.46E+00 2.23E-02 NaN CXCL3, CXCL13, CCL20, MMP12 IL-17A Signaling in Airway Cells 3.38E+00 3.85E-02 NaN CXCL3, CCL20, IL6 Inhibition of Matrix Metalloproteases 2.61E+00 5.13E-02 NaN MMP12, A2M Hepatic Fibrosis / Hepatic Stellate Cell Activation 2.29E+00 1.60E-02 NaN CXCL3, IL6, A2M PXR/RXR Activation 2.18E+00 3.08E-02 NaN GSTA1, IL6 Role of IL-17A in Arthritis 2.13E+00 2.90E-02 NaN CXCL3, CCL20 T Helper Cell Differentiation 2.08E+00 2.74E-02 NaN ICOS, IL6 TREM1 Signaling 2.06E+00 2.67E-02 NaN CXCL3, IL6 Crosstalk between Dendritic Cells and Natural Killer Cells

1.92E+00 2.25E-02 NaN IL6, ACTC1


1.91E+00 2.22E-02 NaN CXCL13, IL6

Airway Pathology in Chronic Obstructive Pulmonary Disease

1.83E+00 1.25E-01 NaN CXCL3

Tryptophan Degradation to 2-amino-3-carboxymuconate Semialdehyde

1.83E+00 1.25E-01 NaN KMO

RhoA Signaling 1.65E+00 1.61E-02 NaN TTN, ACTC1 Atherosclerosis Signaling 1.63E+00 1.57E-02 NaN ALOX12B, IL6 IL-6 Signaling 1.62E+00 1.56E-02 NaN IL6, A2M Glucocorticoid Receptor Signaling 1.59E+00 8.85E-03 NaN CXCL3, IL6, A2M

Th1 Pathway 1.58E+00 1.48E-02 NaN ICOS, IL6 NAD biosynthesis II (from tryptophan) 1.56E+00 6.67E-02 NaN KMO Aryl Hydrocarbon Receptor Signaling 1.54E+00 1.42E-02 NaN GSTA1, IL6 Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F

1.48E+00 5.56E-02 NaN IL6

Methylglyoxal Degradation III 1.46E+00 5.26E-02 NaN Akr1b10 The Visual Cycle 1.43E+00 5.00E-02 NaN Akr1b10 Acute Phase Response Signaling 1.39E+00 1.18E-02 NaN IL6, A2M Fatty Acid α-oxidation 1.39E+00 4.55E-02 NaN ALOX12B Germ Cell-Sertoli Cell Junction Signaling 1.38E+00 1.16E-02 NaN ACTC1, A2M Sertoli Cell-Sertoli Cell Junction Signaling 1.36E+00 1.12E-02 NaN ACTC1, A2M Glutathione Redox Reactions I 1.36E+00 4.17E-02 NaN GSTA1 IL-17A Signaling in Gastric Cells 1.34E+00 4.00E-02 NaN CCL20 Role of JAK family kinases in IL-6-type Cytokine Signaling

1.34E+00 4.00E-02 NaN IL6

Tryptophan Degradation III (Eukaryotic) 1.34E+00 4.00E-02 NaN KMO Th1 and Th2 Activation Pathway 1.33E+00 1.08E-02 NaN ICOS, IL6 NRF2-mediated Oxidative Stress Response 1.30E+00 1.04E-02 NaN GSTA1, ACTC1 IL-15 Production 1.29E+00 3.57E-02 NaN IL6 Glutathione-mediated Detoxification 1.25E+00 3.23E-02 NaN GSTA1 Leukocyte Extravasation Signaling 1.23E+00 9.48E-03 NaN MMP12, ACTC1 Retinoate Biosynthesis I 1.21E+00 2.94E-02 NaN Akr1b10 Integrin Signaling 1.20E+00 9.13E-03 NaN TTN, ACTC1 Coagulation System 1.20E+00 2.86E-02 NaN A2M

IL-17A Signaling in Fibroblasts 1.20E+00 2.86E-02 NaN IL6 Actin Cytoskeleton Signaling 1.17E+00 8.81E-03 NaN TTN, ACTC1 Mechanisms of Viral Exit from Host Cells 1.13E+00 2.44E-02 NaN ACTC1 Retinol Biosynthesis 1.12E+00 2.38E-02 NaN Akr1b10 Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza

1.11E+00 2.33E-02 NaN IL6

Serotonin Receptor Signaling 1.11E+00 2.33E-02 NaN HTR4 Colorectal Cancer Metastasis Signaling 1.10E+00 8.06E-03 NaN IL6, MMP12 Role of IL-17F in Allergic Inflammatory Airway Diseases

1.09E+00 2.22E-02 NaN IL6

Hematopoiesis from Pluripotent Stem Cells 1.07E+00 2.13E-02 NaN IL6 Primary Immunodeficiency Signaling 1.06E+00 2.08E-02 NaN ICOS Graft-versus-Host Disease Signaling 1.06E+00 2.08E-02 NaN IL6 Role of Cytokines in Mediating Communication between Immune Cells

1.02E+00 1.85E-02 NaN IL6

Xenobiotic Metabolism Signaling 9.89E-01 6.90E-03 NaN GSTA1, IL6 Activation of IRF by Cytosolic Pattern Recognition Receptors

9.52E-01 1.59E-02 NaN IL6

Eicosanoid Signaling 9.27E-01 1.49E-02 NaN ALOX12B IL-10 Signaling 9.15E-01 1.45E-02 NaN IL6 Agrin Interactions at Neuromuscular Junction 9.15E-01 1.45E-02 NaN ACTC1 Remodeling of Epithelial Adherens Junctions 9.15E-01 1.45E-02 NaN ACTC1 Caveolar-mediated Endocytosis Signaling 9.04E-01 1.41E-02 NaN ACTC1 MSP-RON Signaling Pathway 8.98E-01 1.39E-02 NaN ACTC1 IL-15 Signaling 8.76E-01 1.32E-02 NaN IL6

JAK/Stat Signaling 8.40E-01 1.20E-02 NaN IL6 IL-17 Signaling 8.31E-01 1.18E-02 NaN IL6 Growth Hormone Signaling 8.31E-01 1.18E-02 NaN A2M Bladder Cancer Signaling 8.17E-01 1.14E-02 NaN MMP12 Regulation of Actin-based Motility by Rho 8.08E-01 1.11E-02 NaN ACTC1 Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes

7.95E-01 1.08E-02 NaN ACTC1

Death Receptor Signaling 7.95E-01 1.08E-02 NaN ACTC1 Communication between Innate and Adaptive Immune Cells

7.91E-01 1.06E-02 NaN IL6

FAK Signaling 7.70E-01 1.01E-02 NaN ACTC1 Protein Kinase A Signaling 7.64E-01 5.00E-03 NaN DUSP3, TTN Virus Entry via Endocytic Pathways 7.58E-01 9.80E-03 NaN ACTC1 VEGF Signaling 7.54E-01 9.71E-03 NaN ACTC1 Oxidative Phosphorylation 7.32E-01 9.17E-03 NaN Cyct Gαs Signaling 7.29E-01 9.09E-03 NaN HTR4 Paxillin Signaling 7.18E-01 8.85E-03 NaN ACTC1 HGF Signaling 7.11E-01 8.70E-03 NaN IL6 HIF1α Signaling 7.01E-01 8.47E-03 NaN MMP12 LXR/RXR Activation 6.91E-01 8.26E-03 NaN IL6 iCOS-iCOSL Signaling in T Helper Cells 6.85E-01 8.13E-03 NaN ICOS Cellular Effects of Sildenafil (Viagra) 6.61E-01 7.63E-03 NaN ACTC1 HMGB1 Signaling 6.55E-01 7.52E-03 NaN IL6 Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses

6.44E-01 7.30E-03 NaN IL6

Epithelial Adherens Junction Signaling 6.19E-01 6.85E-03 NaN ACTC1 Th2 Pathway 6.09E-01 6.67E-03 NaN ICOS Hepatic Cholestasis 5.85E-01 6.25E-03 NaN IL6 Tight Junction Signaling 5.69E-01 5.99E-03 NaN ACTC1 Tec Kinase Signaling 5.62E-01 5.88E-03 NaN ACTC1 eNOS Signaling 5.58E-01 5.81E-03 NaN AQP4 RhoGDI Signaling 5.48E-01 5.65E-03 NaN ACTC1 PPARα/RXRα Activation 5.41E-01 5.56E-03 NaN IL6 Dendritic Cell Maturation 5.16E-01 5.18E-03 NaN IL6 Gap Junction Signaling 5.12E-01 5.13E-03 NaN ACTC1 ILK Signaling 5.09E-01 5.08E-03 NaN ACTC1 Clathrin-mediated Endocytosis Signaling 5.05E-01 5.03E-03 NaN ACTC1 3-phosphoinositide Biosynthesis 5.03E-01 5.00E-03 NaN ICOS Calcium Signaling 4.93E-01 4.85E-03 NaN ACTC1 Osteoarthritis Pathway 4.82E-01 4.72E-03 NaN MMP12 Role of NFAT in Cardiac Hypertrophy 4.71E-01 4.57E-03 NaN IL6 EIF2 Signaling 4.68E-01 4.52E-03 NaN ACTC1 LPS/IL-1 Mediated Inhibition of RXR Function 4.66E-01 4.50E-03 NaN GSTA1 Systemic Lupus Erythematosus Signaling 4.61E-01 4.44E-03 NaN IL6 cAMP-mediated signaling 4.58E-01 4.41E-03 NaN HTR4 Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis

4.49E-01 4.29E-03 NaN IL6

Superpathway of Inositol Phosphate Compounds 4.46E-01 4.26E-03 NaN ICOS Cardiac Hypertrophy Signaling 4.45E-01 4.24E-03 NaN IL6 Signaling by Rho Family GTPases 4.22E-01 3.97E-03 NaN ACTC1

G-Protein Coupled Receptor Signaling 3.91E-01 3.62E-03 NaN HTR4 Neuroinflammation Signaling Pathway 3.52E-01 3.22E-03 NaN IL6 Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis

3.51E-01 3.21E-03 NaN IL6

3 hours

Ingenuity Canonical Pathways −log(P value) Ratio z-score Molecules

Granulocyte Adhesion and Diapedesis 6.86E+00 3.35E-02 NaN CXCL3, IL1RL2, IL1RN, MMP8, CCL20, CSF3

Role of IL-17A in Psoriasis 6.18E+00 2.31E-01 NaN CXCL3, CCL20, S100A8 LXR/RXR Activation 4.66E+00 3.31E-02 -2 IL1RL2, IL1RN, S100A8, IL6 Airway Pathology in Chronic Obstructive Pulmonary Disease

4.30E+00 2.50E-01 NaN CXCL3, MMP8

Role of Cytokines in Mediating Communication between Immune Cells

4.26E+00 5.56E-02 NaN IL1RN, IL6, CSF3

Hepatic Cholestasis 4.19E+00 2.50E-02 NaN ADCY2, IL1RL2, IL1RN, IL6 IL-10 Signaling 3.94E+00 4.35E-02 NaN IL1RL2, IL1RN, IL6 Agranulocyte Adhesion and Diapedesis 3.89E+00 2.09E-02 NaN CXCL3, IL1RN, MMP8, CCL20 IL-17A Signaling in Airway Cells 3.78E+00 3.85E-02 NaN CXCL3, CCL20, IL6 LPS/IL-1 Mediated Inhibition of RXR Function 3.64E+00 1.80E-02 NaN IL1RL2, IL1RN, GSTA1, FABP9 Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F

3.56E+00 1.11E-01 NaN IL6, CSF3

Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis

3.56E+00 1.72E-02 NaN IL1RL2, IL1RN, MMP8, IL6

Atherosclerosis Signaling 3.16E+00 2.36E-02 NaN IL1RN, S100A8, IL6 IL-6 Signaling 3.15E+00 2.34E-02 NaN IL1RL2, IL1RN, IL6 Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza

2.80E+00 4.65E-02 NaN IL1RN, IL6

Serotonin Receptor Signaling 2.80E+00 4.65E-02 NaN ADCY2, HTR4 PPARα/RXRα Activation 2.72E+00 1.67E-02 NaN ADCY2, IL1RL2, IL6 Hematopoiesis from Pluripotent Stem Cells 2.72E+00 4.26E-02 NaN IL6, CSF3 Graft-versus-Host Disease Signaling 2.71E+00 4.17E-02 NaN IL1RN, IL6 Hepatic Fibrosis / Hepatic Stellate Cell Activation 2.68E+00 1.60E-02 NaN CXCL3, IL1RL2, IL6 Dendritic Cell Maturation 2.64E+00 1.55E-02 NaN IL1RL2, IL1RN, IL6 PXR/RXR Activation 2.45E+00 3.08E-02 NaN GSTA1, IL6 Role of IL-17A in Arthritis 2.40E+00 2.90E-02 NaN CXCL3, CCL20 Colorectal Cancer Metastasis Signaling 2.33E+00 1.21E-02 NaN ADCY2, MMP8, IL6 TREM1 Signaling 2.32E+00 2.67E-02 NaN CXCL3, IL6 Altered T Cell and B Cell Signaling in Rheumatoid Arthritis

2.17E+00 2.22E-02 NaN IL1RN, IL6

Communication between Innate and Adaptive Immune Cells

2.13E+00 2.13E-02 NaN IL1RN, IL6

PPAR Signaling 2.13E+00 2.11E-02 NaN IL1RL2, IL1RN Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis

2.06E+00 9.62E-03 NaN IL1RL2, IL1RN, IL6

Gαs Signaling 2.00E+00 1.82E-02 NaN ADCY2, HTR4 Glucocorticoid Receptor Signaling 1.96E+00 8.85E-03 NaN CXCL3, IL1RN, IL6 p38 MAPK Signaling 1.93E+00 1.67E-02 NaN IL1RL2, IL1RN Corticotropin Releasing Hormone Signaling 1.81E+00 1.44E-02 NaN ADCY2, Gucy2d

Aryl Hydrocarbon Receptor Signaling 1.80E+00 1.42E-02 NaN GSTA1, IL6 Hematopoiesis from Multipotent Stem Cells 1.79E+00 8.33E-02 NaN CSF3 Relaxin Signaling 1.71E+00 1.27E-02 NaN ADCY2, Gucy2d Acute Phase Response Signaling 1.65E+00 1.18E-02 NaN IL1RN, IL6 RAR Activation 1.56E+00 1.05E-02 NaN ADCY2, DHRS7C Gap Junction Signaling 1.53E+00 1.03E-02 NaN ADCY2, Gucy2d Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F

1.51E+00 4.35E-02 NaN CSF3

Thrombin Signaling 1.50E+00 9.80E-03 NaN ADCY2, ARHGEF9 Breast Cancer Regulation by Stathmin1 1.49E+00 9.76E-03 NaN ADCY2, ARHGEF9 Glutathione Redox Reactions I 1.49E+00 4.17E-02 NaN GSTA1 IL-17A Signaling in Gastric Cells 1.47E+00 4.00E-02 NaN CCL20 Role of JAK family kinases in IL-6-type Cytokine Signaling

1.47E+00 4.00E-02 NaN IL6

Osteoarthritis Pathway 1.47E+00 9.43E-03 NaN IL1RL2, S100A8 Role of NFAT in Cardiac Hypertrophy 1.44E+00 9.13E-03 NaN ADCY2, IL6 IL-15 Production 1.42E+00 3.57E-02 NaN IL6 Systemic Lupus Erythematosus Signaling 1.42E+00 8.89E-03 NaN IL1RN, IL6 cAMP-mediated signaling 1.41E+00 8.81E-03 NaN ADCY2, HTR4 Cardiac Hypertrophy Signaling 1.38E+00 8.47E-03 NaN ADCY2, IL6 Glutathione-mediated Detoxification 1.38E+00 3.23E-02 NaN GSTA1 Phospholipase C Signaling 1.37E+00 8.30E-03 NaN ADCY2, ARHGEF9 Retinoate Biosynthesis I 1.34E+00 2.94E-02 NaN DHRS7C IL-17A Signaling in Fibroblasts 1.33E+00 2.86E-02 NaN IL6 Inhibition of Matrix Metalloproteases 1.28E+00 2.56E-02 NaN MMP8

Thyroid Cancer Signaling 1.27E+00 2.50E-02 NaN GDNF G-Protein Coupled Receptor Signaling 1.26E+00 7.25E-03 NaN ADCY2, HTR4 Xenobiotic Metabolism Signaling 1.22E+00 6.90E-03 NaN GSTA1, IL6 Role of IL-17F in Allergic Inflammatory Airway Diseases

1.22E+00 2.22E-02 NaN IL6

Neuroinflammation Signaling Pathway 1.17E+00 6.43E-03 NaN GDNF, IL6 Activation of IRF by Cytosolic Pattern Recognition Receptors

1.08E+00 1.59E-02 NaN IL6

T Helper Cell Differentiation 1.02E+00 1.37E-02 NaN IL6 GPCR-Mediated Integration of Enteroendocrine Signaling Exemplified by an L Cell

1.02E+00 1.37E-02 NaN ADCY2

IL-15 Signaling 1.00E+00 1.32E-02 NaN IL6 Antiproliferative Role of Somatostatin Receptor 2 1.00E+00 1.32E-02 NaN Gucy2d GDNF Family Ligand-Receptor Interactions 1.00E+00 1.32E-02 NaN GDNF Toll-like Receptor Signaling 1.00E+00 1.32E-02 NaN IL1RN Dopamine Receptor Signaling 9.98E-01 1.30E-02 NaN ADCY2 Molecular Mechanisms of Cancer 9.95E-01 5.08E-03 NaN ADCY2, ARHGEF9 VDR/RXR Activation 9.93E-01 1.28E-02 NaN CAMP JAK/Stat Signaling 9.67E-01 1.20E-02 NaN IL6 IL-17 Signaling 9.58E-01 1.18E-02 NaN IL6 Leptin Signaling in Obesity 9.53E-01 1.16E-02 NaN ADCY2 α-Adrenergic Signaling 9.48E-01 1.15E-02 NaN ADCY2 PEDF Signaling 9.48E-01 1.15E-02 NaN GDNF Neuregulin Signaling 9.43E-01 1.14E-02 NaN AREG Bladder Cancer Signaling 9.43E-01 1.14E-02 NaN MMP8

HER-2 Signaling in Breast Cancer 9.43E-01 1.14E-02 NaN AREG Crosstalk between Dendritic Cells and Natural Killer Cells

9.39E-01 1.12E-02 NaN IL6

Reelin Signaling in Neurons 9.25E-01 1.09E-02 NaN ARHGEF9 IL-1 Signaling 9.25E-01 1.09E-02 NaN ADCY2 GABA Receptor Signaling 9.12E-01 1.05E-02 NaN ADCY2 TR/RXR Activation 8.99E-01 1.02E-02 NaN TRH Melanocyte Development and Pigmentation Signaling

8.99E-01 1.02E-02 NaN ADCY2

ErbB Signaling 8.99E-01 1.02E-02 NaN AREG CDK5 Signaling 8.95E-01 1.01E-02 NaN ADCY2 Cholecystokinin/Gastrin-mediated Signaling 8.87E-01 9.90E-03 NaN IL1RN Amyotrophic Lateral Sclerosis Signaling 8.49E-01 9.01E-03 NaN GDNF GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells

8.45E-01 8.93E-03 NaN ADCY2

G Beta Gamma Signaling 8.38E-01 8.77E-03 NaN ADCY2 HGF Signaling 8.35E-01 8.70E-03 NaN IL6 HIF1α Signaling 8.24E-01 8.47E-03 NaN MMP8 Gαi Signaling 8.18E-01 8.33E-03 NaN ADCY2 Renin-Angiotensin Signaling 8.11E-01 8.20E-03 NaN ADCY2 Sphingosine-1-phosphate Signaling 8.01E-01 8.00E-03 NaN ADCY2 FXR/RXR Activation 7.98E-01 7.94E-03 NaN IL1RN Cellular Effects of Sildenafil (Viagra) 7.83E-01 7.63E-03 NaN ADCY2 HMGB1 Signaling 7.77E-01 7.52E-03 NaN IL6 P2Y Purigenic Receptor Signaling Pathway 7.74E-01 7.46E-03 NaN ADCY2

Th1 Pathway 7.71E-01 7.41E-03 NaN IL6 Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses

7.65E-01 7.30E-03 NaN IL6

Cardiac β-adrenergic Signaling 7.56E-01 7.14E-03 NaN ADCY2 IL-12 Signaling and Production in Macrophages 7.40E-01 6.85E-03 NaN S100A8 Gustation Pathway 7.21E-01 6.54E-03 NaN ADCY2 Dopamine-DARPP32 Feedback in cAMP Signaling

6.94E-01 6.10E-03 NaN ADCY2

CXCR4 Signaling 6.92E-01 6.06E-03 NaN ADCY2 GNRH Signaling 6.92E-01 6.06E-03 NaN ADCY2 eNOS Signaling 6.76E-01 5.81E-03 NaN ADCY2 Synaptic Long Term Depression 6.71E-01 5.75E-03 NaN Gucy2d RhoGDI Signaling 6.65E-01 5.65E-03 NaN ARHGEF9 NF-κB Signaling 6.56E-01 5.52E-03 NaN IL1RN Th1 and Th2 Activation Pathway 6.48E-01 5.41E-03 NaN IL6 Endothelin-1 Signaling 6.38E-01 5.26E-03 NaN ADCY2 NRF2-mediated Oxidative Stress Response 6.32E-01 5.18E-03 NaN GSTA1 Production of Nitric Oxide and Reactive Oxygen Species in Macrophages

6.30E-01 5.15E-03 NaN S100A8

Clathrin-mediated Endocytosis Signaling 6.20E-01 5.03E-03 NaN S100A8 Leukocyte Extravasation Signaling 5.98E-01 4.74E-03 NaN MMP8 CREB Signaling in Neurons 5.96E-01 4.72E-03 NaN ADCY2 Opioid Signaling Pathway 5.47E-01 4.13E-03 NaN ADCY2 Signaling by Rho Family GTPases 5.32E-01 3.97E-03 NaN ARHGEF9 Protein Kinase A Signaling 3.71E-01 2.50E-03 NaN ADCY2

Axonal Guidance Signaling 3.32E-01 2.21E-03 NaN MMP8

6 hours Ingenuity Canonical Pathways −log(P value) Ratio z-score Molecules

Granulocyte Adhesion and Diapedesis 1.25E+01 5.59E-02 NaN CXCL3, IL1A, SELL, IL1RL2, MMP3, IL1RN, MMP8, CCL20, MMP12

Agranulocyte Adhesion and Diapedesis 9.04E+00 4.19E-02 NaN CXCL3, IL1A, SELL, MMP3, IL1RN, MMP8, CCL20, MMP12 Role of IL-17A in Psoriasis 5.90E+00 2.31E-01 NaN CXCL3, CCL20, S100A8 LXR/RXR Activation 5.74E+00 4.13E-02 -2.236 IL1A, IL1RL2, IL1RN, S100A8, IL6 Role of Cytokines in Mediating Communication between Immune Cells

5.69E+00 7.41E-02 NaN IL1A, IL1RN, IL6, CSF3

Atherosclerosis Signaling 5.64E+00 3.94E-02 NaN IL1A, MMP3, IL1RN, S100A8, IL6 Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis

5.62E+00 2.58E-02 NaN IL1A, IL1RL2, MMP3, IL1RN, MMP8, IL6

IL-10 Signaling 5.26E+00 5.80E-02 NaN IL1A, IL1RL2, IL1RN, IL6 Inhibition of Matrix Metalloproteases 4.41E+00 7.69E-02 NaN MMP3, MMP8, MMP12 Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza

4.28E+00 6.98E-02 NaN IL1A, IL1RN, IL6

IL-6 Signaling 4.20E+00 3.12E-02 2 IL1A, IL1RL2, IL1RN, IL6 Hematopoiesis from Pluripotent Stem Cells 4.16E+00 6.38E-02 NaN IL1A, IL6, CSF3 Graft-versus-Host Disease Signaling 4.14E+00 6.25E-02 NaN IL1A, IL1RN, IL6 Airway Pathology in Chronic Obstructive Pulmonary Disease

4.11E+00 2.50E-01 NaN CXCL3, MMP8

Nicotine Degradation III 3.96E+00 5.45E-02 NaN CYP1A1, UGT2A1, UGT1A1

Xenobiotic Metabolism Signaling 3.91E+00 1.72E-02 NaN CYP1A1, IL1A, UGT2A1, IL6, UGT1A1

Hepatic Cholestasis 3.82E+00 2.50E-02 NaN IL1A, IL1RL2, IL1RN, IL6 Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis

3.77E+00 1.60E-02 NaN IL1A, IL1RL2, MMP3, IL1RN, IL6

Melatonin Degradation I 3.76E+00 4.69E-02 NaN CYP1A1, UGT2A1, UGT1A1 Nicotine Degradation II 3.76E+00 4.69E-02 NaN CYP1A1, UGT2A1, UGT1A1 Superpathway of Melatonin Degradation 3.67E+00 4.35E-02 NaN CYP1A1, UGT2A1, UGT1A1 Hepatic Fibrosis / Hepatic Stellate Cell Activation

3.56E+00 2.14E-02 NaN CXCL3, IL1A, IL1RL2, IL6

Dendritic Cell Maturation 3.51E+00 2.07E-02 NaN IL1A, IL1RL2, IL1RN, IL6 IL-17A Signaling in Airway Cells 3.51E+00 3.85E-02 NaN CXCL3, CCL20, IL6 Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F

3.38E+00 1.11E-01 NaN IL6, CSF3

Osteoarthritis Pathway 3.36E+00 1.89E-02 NaN IL1RL2, MMP3, S100A8, MMP12 Bladder Cancer Signaling 3.35E+00 3.41E-02 NaN MMP3, MMP8, MMP12 Altered T Cell and B Cell Signaling in Rheumatoid Arthritis

3.33E+00 3.33E-02 NaN IL1A, IL1RN, IL6


3.27E+00 3.19E-02 NaN IL1A, IL1RN, IL6

PPAR Signaling 3.26E+00 3.16E-02 NaN IL1A, IL1RL2, IL1RN ErbB Signaling 3.22E+00 3.06E-02 NaN PAK1, EREG, AREG Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F

3.16E+00 8.70E-02 NaN IL1A, CSF3

Colorectal Cancer Metastasis Signaling 3.10E+00 1.61E-02 2 MMP3, MMP8, IL6, MMP12

HIF1α Signaling 2.98E+00 2.54E-02 NaN MMP3, MMP8, MMP12 p38 MAPK Signaling 2.96E+00 2.50E-02 NaN IL1A, IL1RL2, IL1RN Aryl Hydrocarbon Receptor Signaling 2.76E+00 2.13E-02 NaN CYP1A1, IL1A, IL6 Thyroid Hormone Metabolism II (via Conjugation and/or Degradation)

2.64E+00 4.76E-02 NaN UGT2A1, UGT1A1

Acute Phase Response Signaling 2.53E+00 1.76E-02 NaN IL1A, IL1RN, IL6 Glutathione Biosynthesis 2.30E+00 3.33E-01 NaN GCLM Leukocyte Extravasation Signaling 2.27E+00 1.42E-02 NaN MMP3, MMP8, MMP12 PXR/RXR Activation 2.27E+00 3.08E-02 NaN IL6, UGT1A1 Role of IL-17A in Arthritis 2.22E+00 2.90E-02 NaN CXCL3, CCL20 LPS/IL-1 Mediated Inhibition of RXR Function 2.21E+00 1.35E-02 NaN IL1A, IL1RL2, IL1RN Systemic Lupus Erythematosus Signaling 2.19E+00 1.33E-02 NaN IL1A, IL1RN, IL6 TREM1 Signaling 2.15E+00 2.67E-02 NaN CXCL3, IL6 Serotonin Degradation 2.13E+00 2.63E-02 NaN UGT2A1, UGT1A1 Toll-like Receptor Signaling 2.13E+00 2.63E-02 NaN IL1A, IL1RN VDR/RXR Activation 2.11E+00 2.56E-02 NaN CYP24A1, CAMP Tyrosine Degradation I 2.07E+00 2.00E-01 NaN HGD IL-17 Signaling 2.04E+00 2.35E-02 NaN MMP3, IL6 Neuregulin Signaling 2.01E+00 2.27E-02 NaN EREG, AREG Cholecystokinin/Gastrin-mediated Signaling 1.90E+00 1.98E-02 NaN IL1A, IL1RN Amyotrophic Lateral Sclerosis Signaling 1.82E+00 1.80E-02 NaN PAK1, GDNF Neuroinflammation Signaling Pathway 1.81E+00 9.65E-03 NaN MMP3, GDNF, IL6 HGF Signaling 1.79E+00 1.74E-02 NaN PAK1, IL6 FXR/RXR Activation 1.72E+00 1.59E-02 NaN IL1A, IL1RN Glucocorticoid Receptor Signaling 1.71E+00 8.85E-03 NaN CXCL3, IL1RN, IL6

Hematopoiesis from Multipotent Stem Cells 1.70E+00 8.33E-02 NaN CSF3 HMGB1 Signaling 1.67E+00 1.50E-02 NaN IL1A, IL6 Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses

1.65E+00 1.46E-02 NaN IL1A, IL6

γ-glutamyl Cycle 1.63E+00 7.14E-02 NaN GCLM PPARα/RXRα Activation 1.43E+00 1.11E-02 NaN IL1RL2, IL6 NF-κB Signaling 1.43E+00 1.10E-02 NaN IL1A, IL1RN Axonal Guidance Signaling 1.39E+00 6.64E-03 NaN PAK1, MMP3, MMP8 IL-17A Signaling in Gastric Cells 1.38E+00 4.00E-02 NaN CCL20 Role of JAK family kinases in IL-6-type Cytokine Signaling

1.38E+00 4.00E-02 NaN IL6

Bupropion Degradation 1.38E+00 4.00E-02 NaN CYP1A1 IL-15 Production 1.33E+00 3.57E-02 NaN IL6 Acetone Degradation I (to Methylglyoxal) 1.31E+00 3.33E-02 NaN CYP1A1 Oncostatin M Signaling 1.25E+00 2.94E-02 NaN MMP3 IL-17A Signaling in Fibroblasts 1.24E+00 2.86E-02 NaN IL6 Thyroid Cancer Signaling 1.18E+00 2.50E-02 NaN GDNF Estrogen Biosynthesis 1.18E+00 2.50E-02 NaN CYP1A1 Role of IL-17F in Allergic Inflammatory Airway Diseases

1.13E+00 2.22E-02 NaN IL6

TNFR1 Signaling 1.09E+00 2.00E-02 NaN PAK1 Semaphorin Signaling in Neurons 1.07E+00 1.89E-02 NaN PAK1 Ephrin A Signaling 1.01E+00 1.67E-02 NaN PAK1 Activation of IRF by Cytosolic Pattern Recognition Receptors

9.95E-01 1.59E-02 NaN IL6

Pyridoxal 5'-phosphate Salvage Pathway 9.82E-01 1.54E-02 NaN PAK1 Agrin Interactions at Neuromuscular Junction 9.57E-01 1.45E-02 NaN PAK1 T Helper Cell Differentiation 9.34E-01 1.37E-02 NaN IL6 Ephrin B Signaling 9.34E-01 1.37E-02 NaN PAK1 IL-15 Signaling 9.18E-01 1.32E-02 NaN IL6 GDNF Family Ligand-Receptor Interactions 9.18E-01 1.32E-02 NaN GDNF Angiopoietin Signaling 9.07E-01 1.28E-02 NaN PAK1 Macropinocytosis Signaling 8.92E-01 1.23E-02 NaN PAK1 IL-3 Signaling 8.82E-01 1.20E-02 NaN PAK1 Renal Cell Carcinoma Signaling 8.82E-01 1.20E-02 NaN PAK1 JAK/Stat Signaling 8.82E-01 1.20E-02 NaN IL6 LPS-stimulated MAPK Signaling 8.63E-01 1.15E-02 NaN PAK1 PEDF Signaling 8.63E-01 1.15E-02 NaN GDNF HER-2 Signaling in Breast Cancer 8.58E-01 1.14E-02 NaN AREG Crosstalk between Dendritic Cells and Natural Killer Cells

8.54E-01 1.12E-02 NaN IL6

Regulation of Actin-based Motility by Rho 8.49E-01 1.11E-02 NaN PAK1 IL-1 Signaling 8.40E-01 1.09E-02 NaN IL1A Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes

8.36E-01 1.08E-02 NaN PAK1

Salvage Pathways of Pyrimidine Ribonucleotides

8.27E-01 1.05E-02 NaN PAK1

TR/RXR Activation 8.15E-01 1.02E-02 NaN TRH FAK Signaling 8.11E-01 1.01E-02 NaN PAK1 PAK Signaling 8.03E-01 9.90E-03 NaN PAK1

Paxillin Signaling 7.58E-01 8.85E-03 NaN PAK1 G Beta Gamma Signaling 7.55E-01 8.77E-03 NaN PAK1 Rac Signaling 7.45E-01 8.55E-03 NaN PAK1 Natural Killer Cell Signaling 7.28E-01 8.20E-03 NaN PAK1 Renin-Angiotensin Signaling 7.28E-01 8.20E-03 NaN PAK1 Role of Tissue Factor in Cancer 7.25E-01 8.13E-03 NaN PAK1 CCR3 Signaling in Eosinophils 7.03E-01 7.69E-03 NaN PAK1 CD28 Signaling in T Helper Cells 6.97E-01 7.58E-03 NaN PAK1 Th1 Pathway 6.89E-01 7.41E-03 NaN IL6 IL-12 Signaling and Production in Macrophages 6.58E-01 6.85E-03 NaN S100A8 CXCR4 Signaling 6.12E-01 6.06E-03 NaN PAK1 GNRH Signaling 6.12E-01 6.06E-03 NaN PAK1 Cdc42 Signaling 6.07E-01 5.99E-03 NaN PAK1 Tec Kinase Signaling 6.01E-01 5.88E-03 NaN PAK1 Germ Cell-Sertoli Cell Junction Signaling 5.94E-01 5.78E-03 NaN PAK1 Ephrin Receptor Signaling 5.90E-01 5.71E-03 NaN PAK1 RhoGDI Signaling 5.85E-01 5.65E-03 NaN PAK1 Th1 and Th2 Activation Pathway 5.69E-01 5.41E-03 NaN IL6 NRF2-mediated Oxidative Stress Response 5.53E-01 5.18E-03 NaN GCLM Production of Nitric Oxide and Reactive Oxygen Species in Macrophages

5.51E-01 5.15E-03 NaN S100A8

Clathrin-mediated Endocytosis Signaling 5.42E-01 5.03E-03 NaN S100A8 ERK/MAPK Signaling 5.40E-01 5.00E-03 NaN PAK1 Breast Cancer Regulation by Stathmin1 5.31E-01 4.88E-03 NaN PAK1 Role of NFAT in Cardiac Hypertrophy 5.07E-01 4.57E-03 NaN IL6

Integrin Signaling 5.07E-01 4.57E-03 NaN PAK1 Actin Cytoskeleton Signaling 4.94E-01 4.41E-03 NaN PAK1 Cardiac Hypertrophy Signaling 4.81E-01 4.24E-03 NaN IL6 Signaling by Rho Family GTPases 4.57E-01 3.97E-03 NaN PAK1 Molecular Mechanisms of Cancer 3.10E-01 2.54E-03 NaN PAK1

9 hours Ingenuity Canonical Pathways −log(P value) Ratio z-score Molecules

Granulocyte Adhesion and Diapedesis 1.30E+01 6.15E-02 NaN CXCL3, IL1A, SELL, IL1RL2, MMP3, IL1RN, MMP8, CCL20, CSF3, MMP12, Ccl9

Agranulocyte Adhesion and Diapedesis

1.11E+01 5.24E-02 NaN CXCL3, IL1A, SELL, MMP3, IL1RN, MMP8, CCL20, MMP12, ACTC1, Ccl9


6.21E+00 3.00E-02 NaN IL1A, IL1RL2, MMP3, IL1RN, MMP8, IL6, PTH

Role of IL-17A in Psoriasis 5.58E+00 2.31E-01 NaN CXCL3, CCL20, S100A8 Role of Cytokines in Mediating Communication between Immune Cells

5.26E+00 7.41E-02 NaN IL1A, IL1RN, IL6, CSF3

LXR/RXR Activation 5.22E+00 4.13E-02 -2.236 IL1A, IL1RL2, IL1RN, S100A8, IL6 Atherosclerosis Signaling 5.11E+00 3.94E-02 NaN IL1A, MMP3, IL1RN, S100A8, IL6 IL-10 Signaling 4.84E+00 5.80E-02 NaN IL1A, IL1RL2, IL1RN, IL6 Communication between Innate and Adaptive Immune Cells

4.31E+00 4.26E-02 NaN IL1A, IL1RN, IL6, Ccl9

Inhibition of Matrix Metalloproteases 4.09E+00 7.69E-02 NaN MMP3, MMP8, MMP12

Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza

3.97E+00 6.98E-02 NaN IL1A, IL1RN, IL6

Airway Pathology in Chronic Obstructive Pulmonary Disease

3.90E+00 2.50E-01 NaN CXCL3, MMP8

Hematopoiesis from Pluripotent Stem Cells

3.85E+00 6.38E-02 NaN IL1A, IL6, CSF3

Graft-versus-Host Disease Signaling 3.82E+00 6.25E-02 NaN IL1A, IL1RN, IL6 IL-6 Signaling 3.79E+00 3.12E-02 2 IL1A, IL1RL2, IL1RN, IL6 Aryl Hydrocarbon Receptor Signaling 3.62E+00 2.84E-02 NaN CYP1A1, IL1A, GSTA1, IL6 Hepatic Cholestasis 3.42E+00 2.50E-02 NaN IL1A, IL1RL2, IL1RN, IL6 Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis

3.27E+00 1.60E-02 NaN IL1A, IL1RL2, MMP3, IL1RN, IL6

VDR/RXR Activation 3.20E+00 3.85E-02 NaN CYP24A1, CAMP, PTH IL-17A Signaling in Airway Cells 3.20E+00 3.85E-02 NaN CXCL3, CCL20, IL6 Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F

3.17E+00 1.11E-01 NaN IL6, CSF3

Hepatic Fibrosis / Hepatic Stellate Cell Activation

3.16E+00 2.14E-02 NaN CXCL3, IL1A, IL1RL2, IL6

Dendritic Cell Maturation 3.11E+00 2.07E-02 NaN IL1A, IL1RL2, IL1RN, IL6 Bladder Cancer Signaling 3.05E+00 3.41E-02 NaN MMP3, MMP8, MMP12 Altered T Cell and B Cell Signaling in Rheumatoid Arthritis

3.02E+00 3.33E-02 NaN IL1A, IL1RN, IL6

Leukocyte Extravasation Signaling 2.97E+00 1.90E-02 1 MMP3, MMP8, MMP12, ACTC1

Osteoarthritis Pathway 2.96E+00 1.89E-02 NaN IL1RL2, MMP3, S100A8, MMP12 Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F

2.95E+00 8.70E-02 NaN IL1A, CSF3

PPAR Signaling 2.95E+00 3.16E-02 NaN IL1A, IL1RL2, IL1RN LPS/IL-1 Mediated Inhibition of RXR Function

2.88E+00 1.80E-02 NaN IL1A, IL1RL2, IL1RN, GSTA1

Colorectal Cancer Metastasis Signaling

2.71E+00 1.61E-02 2 MMP3, MMP8, IL6, MMP12

HIF1α Signaling 2.68E+00 2.54E-02 NaN MMP3, MMP8, MMP12 p38 MAPK Signaling 2.66E+00 2.50E-02 NaN IL1A, IL1RL2, IL1RN Xenobiotic Metabolism Signaling 2.46E+00 1.38E-02 NaN CYP1A1, IL1A, GSTA1, IL6 Acute Phase Response Signaling 2.24E+00 1.76E-02 NaN IL1A, IL1RN, IL6 Glutathione Biosynthesis 2.19E+00 3.33E-01 NaN GCLM NRF2-mediated Oxidative Stress Response

2.08E+00 1.55E-02 NaN GSTA1, GCLM, ACTC1

PXR/RXR Activation 2.06E+00 3.08E-02 NaN GSTA1, IL6 Role of IL-17A in Arthritis 2.01E+00 2.90E-02 NaN CXCL3, CCL20 TREM1 Signaling 1.95E+00 2.67E-02 NaN CXCL3, IL6 Toll-like Receptor Signaling 1.93E+00 2.63E-02 NaN IL1A, IL1RN Systemic Lupus Erythematosus Signaling

1.90E+00 1.33E-02 NaN IL1A, IL1RN, IL6

IL-17 Signaling 1.84E+00 2.35E-02 NaN MMP3, IL6 Neuregulin Signaling 1.81E+00 2.27E-02 NaN EREG, AREG

Crosstalk between Dendritic Cells and Natural Killer Cells

1.80E+00 2.25E-02 NaN IL6, ACTC1

Histidine Degradation III 1.77E+00 1.25E-01 NaN HAL ErbB Signaling 1.73E+00 2.04E-02 NaN EREG, AREG Cholecystokinin/Gastrin-mediated Signaling

1.70E+00 1.98E-02 NaN IL1A, IL1RN

Hematopoiesis from Multipotent Stem Cells

1.59E+00 8.33E-02 NaN CSF3

Glycogen Degradation II 1.56E+00 7.69E-02 NaN PYGM Neuroinflammation Signaling Pathway 1.54E+00 9.65E-03 NaN MMP3, GDNF, IL6 RhoA Signaling 1.54E+00 1.61E-02 NaN LPAR3, ACTC1 γ-glutamyl Cycle 1.53E+00 7.14E-02 NaN GCLM FXR/RXR Activation 1.52E+00 1.59E-02 NaN IL1A, IL1RN Glycogen Degradation III 1.50E+00 6.67E-02 NaN PYGM Histidine Degradation VI 1.50E+00 6.67E-02 NaN HAL HMGB1 Signaling 1.48E+00 1.50E-02 NaN IL1A, IL6 Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses

1.46E+00 1.46E-02 NaN IL1A, IL6

Glucocorticoid Receptor Signaling 1.44E+00 8.85E-03 NaN CXCL3, IL1RN, IL6 Glutathione Redox Reactions I 1.30E+00 4.17E-02 NaN GSTA1 IL-17A Signaling in Gastric Cells 1.28E+00 4.00E-02 NaN CCL20 Role of JAK family kinases in IL-6-type Cytokine Signaling

1.28E+00 4.00E-02 NaN IL6

Bupropion Degradation 1.28E+00 4.00E-02 NaN CYP1A1 PPARα/RXRα Activation 1.24E+00 1.11E-02 NaN IL1RL2, IL6

NF-κB Signaling 1.24E+00 1.10E-02 NaN IL1A, IL1RN IL-15 Production 1.23E+00 3.57E-02 NaN IL6 Acetone Degradation I (to Methylglyoxal)

1.20E+00 3.33E-02 NaN CYP1A1

Glutathione-mediated Detoxification 1.19E+00 3.23E-02 NaN GSTA1 Clathrin-mediated Endocytosis Signaling

1.17E+00 1.01E-02 NaN S100A8, ACTC1

Oncostatin M Signaling 1.15E+00 2.94E-02 NaN MMP3 IL-17A Signaling in Fibroblasts 1.14E+00 2.86E-02 NaN IL6 Thyroid Cancer Signaling 1.08E+00 2.50E-02 NaN GDNF Estrogen Biosynthesis 1.08E+00 2.50E-02 NaN CYP1A1 Mechanisms of Viral Exit from Host Cells

1.07E+00 2.44E-02 NaN ACTC1

Role of IL-17F in Allergic Inflammatory Airway Diseases

1.03E+00 2.22E-02 NaN IL6

Nicotine Degradation III 9.52E-01 1.82E-02 NaN CYP1A1 Activation of IRF by Cytosolic Pattern Recognition Receptors

8.97E-01 1.59E-02 NaN IL6

Melatonin Degradation I 8.90E-01 1.56E-02 NaN CYP1A1 Nicotine Degradation II 8.90E-01 1.56E-02 NaN CYP1A1 Agrin Interactions at Neuromuscular Junction

8.60E-01 1.45E-02 NaN ACTC1

Superpathway of Melatonin Degradation

8.60E-01 1.45E-02 NaN CYP1A1

Remodeling of Epithelial Adherens Junctions

8.60E-01 1.45E-02 NaN ACTC1

Caveolar-mediated Endocytosis Signaling

8.48E-01 1.41E-02 NaN ACTC1

MSP-RON Signaling Pathway 8.43E-01 1.39E-02 NaN ACTC1 T Helper Cell Differentiation 8.37E-01 1.37E-02 NaN IL6 IL-15 Signaling 8.21E-01 1.32E-02 NaN IL6 GDNF Family Ligand-Receptor Interactions

8.21E-01 1.32E-02 NaN GDNF

Dopamine Receptor Signaling 8.16E-01 1.30E-02 NaN PTH JAK/Stat Signaling 7.86E-01 1.20E-02 NaN IL6 α-Adrenergic Signaling 7.67E-01 1.15E-02 NaN PYGM PEDF Signaling 7.67E-01 1.15E-02 NaN GDNF HER-2 Signaling in Breast Cancer 7.63E-01 1.14E-02 NaN AREG Regulation of Actin-based Motility by Rho

7.54E-01 1.11E-02 NaN ACTC1

IL-1 Signaling 7.45E-01 1.09E-02 NaN IL1A Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes

7.41E-01 1.08E-02 NaN ACTC1

Death Receptor Signaling 7.41E-01 1.08E-02 NaN ACTC1 TR/RXR Activation 7.20E-01 1.02E-02 NaN TRH FAK Signaling 7.16E-01 1.01E-02 NaN ACTC1 Virus Entry via Endocytic Pathways 7.05E-01 9.80E-03 NaN ACTC1 VEGF Signaling 7.01E-01 9.71E-03 NaN ACTC1 Amyotrophic Lateral Sclerosis Signaling

6.72E-01 9.01E-03 NaN GDNF

Paxillin Signaling 6.65E-01 8.85E-03 NaN ACTC1

HGF Signaling 6.58E-01 8.70E-03 NaN IL6 Cellular Effects of Sildenafil (Viagra) 6.09E-01 7.63E-03 NaN ACTC1 Gα12/13 Signaling 5.98E-01 7.41E-03 NaN LPAR3 Th1 Pathway 5.98E-01 7.41E-03 NaN IL6 Axonal Guidance Signaling 5.96E-01 4.42E-03 NaN MMP3, MMP8 IL-12 Signaling and Production in Macrophages

5.68E-01 6.85E-03 NaN S100A8

Epithelial Adherens Junction Signaling 5.68E-01 6.85E-03 NaN ACTC1 Tight Junction Signaling 5.19E-01 5.99E-03 NaN ACTC1 Tec Kinase Signaling 5.13E-01 5.88E-03 NaN ACTC1 eNOS Signaling 5.08E-01 5.81E-03 NaN LPAR3 Germ Cell-Sertoli Cell Junction Signaling

5.06E-01 5.78E-03 NaN ACTC1

RhoGDI Signaling 4.98E-01 5.65E-03 NaN ACTC1 Sertoli Cell-Sertoli Cell Junction Signaling

4.96E-01 5.62E-03 NaN ACTC1

Th1 and Th2 Activation Pathway 4.82E-01 5.41E-03 NaN IL6 Production of Nitric Oxide and Reactive Oxygen Species in Macrophages

4.66E-01 5.15E-03 NaN S100A8

Gap Junction Signaling 4.64E-01 5.13E-03 NaN ACTC1 ILK Signaling 4.60E-01 5.08E-03 NaN ACTC1 Calcium Signaling 4.45E-01 4.85E-03 NaN ACTC1 Role of NFAT in Cardiac Hypertrophy 4.24E-01 4.57E-03 NaN IL6 Integrin Signaling 4.24E-01 4.57E-03 NaN ACTC1

EIF2 Signaling 4.21E-01 4.52E-03 NaN ACTC1 Actin Cytoskeleton Signaling 4.11E-01 4.41E-03 NaN ACTC1 Cardiac Hypertrophy Signaling 3.98E-01 4.24E-03 NaN IL6 Signaling by Rho Family GTPases 3.77E-01 3.97E-03 NaN ACTC1 Protein Kinase A Signaling 2.36E-01 2.50E-03 NaN PYGM

1 day

Ingenuity Canonical Pathways −log(P value)

Ratio z-score Molecules

LXR/RXR Activation 4.36E+00 4.13E-02 -2 ABCG8, IL1RL2, IL1RN, S100A8, IL6 LPS/IL-1 Mediated Inhibition of RXR Function

4.11E+00 2.70E-02 NaN ABCG8, Cyp2a12/Cyp2a22, IL1RL2, IL1RN, GSTA1, FABP9

Hepatic Cholestasis 3.79E+00 3.12E-02 NaN ABCG8, IL1RL2, IL1RN, IL6, IL11 Communication between Innate and Adaptive Immune Cells

3.63E+00 4.26E-02 NaN IL1RN, IL6, CD8A, Ccl9

Granulocyte Adhesion and Diapedesis 3.56E+00 2.79E-02 NaN IL1RL2, IL1RN, CCL20, MMP12, Ccl9 Hematopoiesis from Pluripotent Stem Cells

3.34E+00 6.38E-02 NaN IL6, CD8A, IL11

IL-6 Signaling 3.12E+00 3.12E-02 2 IL1RL2, IL1RN, CRP, IL6 Role of IL-17A in Psoriasis 3.11E+00 1.54E-01 NaN CCL20, S100A8 Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis

3.04E+00 2.15E-02 NaN IL1RL2, IL1RN, IL6, PTH, IL11

Aryl Hydrocarbon Receptor Signaling 2.96E+00 2.84E-02 NaN CYP1A1, CYP1A2, GSTA1, IL6 PXR/RXR Activation 2.93E+00 4.62E-02 NaN CYP1A2, GSTA1, IL6

IL-10 Signaling 2.85E+00 4.35E-02 NaN IL1RL2, IL1RN, IL6 Bupropion Degradation 2.54E+00 8.00E-02 NaN CYP1A1, CYP1A2 Agranulocyte Adhesion and Diapedesis 2.48E+00 2.09E-02 NaN IL1RN, CCL20, MMP12, Ccl9 Acetone Degradation I (to Methylglyoxal) 2.38E+00 6.67E-02 NaN CYP1A1, CYP1A2 Glycine Biosynthesis III 2.19E+00 5.00E-01 NaN AGXT Estrogen Biosynthesis 2.14E+00 5.00E-02 NaN CYP1A1, CYP1A2 Atherosclerosis Signaling 2.10E+00 2.36E-02 NaN IL1RN, S100A8, IL6 Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza

2.08E+00 4.65E-02 NaN IL1RN, IL6

Role of IL-17F in Allergic Inflammatory Airway Diseases

2.04E+00 4.44E-02 NaN IL6, IL11

Glutathione Biosynthesis 2.02E+00 3.33E-01 NaN GCLM Graft-versus-Host Disease Signaling 1.99E+00 4.17E-02 NaN IL1RN, IL6 Role of Cytokines in Mediating Communication between Immune Cells

1.89E+00 3.70E-02 NaN IL1RN, IL6

Nicotine Degradation III 1.87E+00 3.64E-02 NaN CYP1A1, CYP1A2 Xenobiotic Metabolism Signaling 1.85E+00 1.38E-02 NaN CYP1A1, CYP1A2, GSTA1, IL6 Acute Phase Response Signaling 1.76E+00 1.76E-02 NaN IL1RN, CRP, IL6 Melatonin Degradation I 1.75E+00 3.12E-02 NaN CYP1A1, CYP1A2 Nicotine Degradation II 1.75E+00 3.12E-02 NaN CYP1A1, CYP1A2 Superpathway of Melatonin Degradation 1.69E+00 2.90E-02 NaN CYP1A1, CYP1A2 Aspartate Degradation II 1.65E+00 1.43E-01 NaN LIPF Dendritic Cell Maturation 1.62E+00 1.55E-02 NaN IL1RL2, IL1RN, IL6 TREM1 Signaling 1.62E+00 2.67E-02 NaN NLRP4, IL6

Histidine Degradation III 1.60E+00 1.25E-01 NaN HAL IL-17A Signaling in Airway Cells 1.59E+00 2.56E-02 NaN CCL20, IL6 IL-17 Signaling 1.52E+00 2.35E-02 NaN CRP, IL6 Osteoarthritis Pathway 1.52E+00 1.42E-02 NaN IL1RL2, S100A8, MMP12 Calcium Transport I 1.50E+00 1.00E-01 NaN ATP2B2 Altered T Cell and B Cell Signaling in Rheumatoid Arthritis

1.47E+00 2.22E-02 NaN IL1RN, IL6

PPAR Signaling 1.43E+00 2.11E-02 NaN IL1RL2, IL1RN Guanosine Nucleotides Degradation III 1.42E+00 8.33E-02 NaN ACPP Urate Biosynthesis/Inosine 5'-phosphate Degradation

1.39E+00 7.69E-02 NaN ACPP

NAD Phosphorylation and Dephosphorylation

1.39E+00 7.69E-02 NaN ACPP

γ-glutamyl Cycle 1.36E+00 7.14E-02 NaN GCLM Histidine Degradation VI 1.33E+00 6.67E-02 NaN HAL Amyotrophic Lateral Sclerosis Signaling 1.31E+00 1.80E-02 NaN GDNF, GRIA2 Adenosine Nucleotides Degradation II 1.30E+00 6.25E-02 NaN ACPP Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F

1.25E+00 5.56E-02 NaN IL6

p38 MAPK Signaling 1.25E+00 1.67E-02 NaN IL1RL2, IL1RN Purine Nucleotides Degradation II (Aerobic)

1.23E+00 5.26E-02 NaN ACPP

FXR/RXR Activation 1.21E+00 1.59E-02 NaN ABCG8, IL1RN HMGB1 Signaling 1.17E+00 1.50E-02 NaN IL6, IL11

Th1 Pathway 1.16E+00 1.48E-02 NaN IL6, CD8A Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses

1.15E+00 1.46E-02 NaN IL6, IL11

Glutathione Redox Reactions I 1.13E+00 4.17E-02 NaN GSTA1 TCA Cycle II (Eukaryotic) 1.13E+00 4.17E-02 NaN LIPF IL-17A Signaling in Gastric Cells 1.11E+00 4.00E-02 NaN CCL20 Role of JAK family kinases in IL-6-type Cytokine Signaling

1.11E+00 4.00E-02 NaN IL6

Neuroinflammation Signaling Pathway 1.11E+00 9.65E-03 NaN GDNF, CRP, IL6 Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis

1.11E+00 9.62E-03 NaN IL1RL2, IL1RN, IL6

NAD Salvage Pathway II 1.10E+00 3.85E-02 NaN ACPP Gluconeogenesis I 1.10E+00 3.85E-02 NaN LIPF IL-15 Production 1.07E+00 3.57E-02 NaN IL6 Glutathione-mediated Detoxification 1.02E+00 3.23E-02 NaN GSTA1 IL-17A Signaling in Fibroblasts 9.74E-01 2.86E-02 NaN IL6 Synaptic Long Term Depression 9.70E-01 1.15E-02 NaN Gucy2d, GRIA2 PPARα/RXRα Activation 9.46E-01 1.11E-02 NaN IL1RL2, IL6 Inhibition of Matrix Metalloproteases 9.30E-01 2.56E-02 NaN MMP12 Th1 and Th2 Activation Pathway 9.27E-01 1.08E-02 NaN IL6, CD8A Thyroid Cancer Signaling 9.19E-01 2.50E-02 NaN GDNF Hepatic Fibrosis / Hepatic Stellate Cell Activation

9.19E-01 1.07E-02 NaN IL1RL2, IL6

Retinol Biosynthesis 9.00E-01 2.38E-02 NaN LIPF

NRF2-mediated Oxidative Stress Response

8.97E-01 1.04E-02 NaN GSTA1, GCLM

Gap Junction Signaling 8.89E-01 1.03E-02 NaN Gucy2d, GRIA2 Calcium Signaling 8.51E-01 9.71E-03 NaN GRIA2, ATP2B2 Primary Immunodeficiency Signaling 8.46E-01 2.08E-02 NaN CD8A Role of NFAT in Cardiac Hypertrophy 8.09E-01 9.13E-03 NaN IL6, IL11 Triacylglycerol Degradation 8.06E-01 1.89E-02 NaN LIPF Transcriptional Regulatory Network in Embryonic Stem Cells

7.98E-01 1.85E-02 NaN SIX3

Systemic Lupus Erythematosus Signaling 7.90E-01 8.89E-03 NaN IL1RN, IL6 Glutamate Receptor Signaling 7.77E-01 1.75E-02 NaN GRIA2 Activation of IRF by Cytosolic Pattern Recognition Receptors

7.37E-01 1.59E-02 NaN IL6

Colorectal Cancer Metastasis Signaling 7.25E-01 8.06E-03 NaN IL6, MMP12 Role of IL-17A in Arthritis 7.02E-01 1.45E-02 NaN CCL20 T Helper Cell Differentiation 6.80E-01 1.37E-02 NaN IL6 GPCR-Mediated Integration of Enteroendocrine Signaling Exemplified by an L Cell

6.80E-01 1.37E-02 NaN GALR1

IL-15 Signaling 6.65E-01 1.32E-02 NaN IL6 Antiproliferative Role of Somatostatin Receptor 2

6.65E-01 1.32E-02 NaN Gucy2d

GDNF Family Ligand-Receptor Interactions

6.65E-01 1.32E-02 NaN GDNF

Toll-like Receptor Signaling 6.65E-01 1.32E-02 NaN IL1RN

Dopamine Receptor Signaling 6.60E-01 1.30E-02 NaN PTH VDR/RXR Activation 6.55E-01 1.28E-02 NaN PTH JAK/Stat Signaling 6.31E-01 1.20E-02 NaN IL6 PEDF Signaling 6.13E-01 1.15E-02 NaN GDNF Neuregulin Signaling 6.09E-01 1.14E-02 NaN AREG Bladder Cancer Signaling 6.09E-01 1.14E-02 NaN MMP12 HER-2 Signaling in Breast Cancer 6.09E-01 1.14E-02 NaN AREG Crosstalk between Dendritic Cells and Natural Killer Cells

6.05E-01 1.12E-02 NaN IL6

TR/RXR Activation 5.69E-01 1.02E-02 NaN TRH ErbB Signaling 5.69E-01 1.02E-02 NaN AREG CTLA4 Signaling in Cytotoxic T Lymphocytes

5.65E-01 1.01E-02 NaN CD8A

Cholecystokinin/Gastrin-mediated Signaling

5.58E-01 9.90E-03 NaN IL1RN

T Cell Receptor Signaling 5.30E-01 9.17E-03 NaN CD8A Glucocorticoid Receptor Signaling 5.29E-01 5.90E-03 NaN IL1RN, IL6 Neuropathic Pain Signaling In Dorsal Horn Neurons

5.10E-01 8.70E-03 NaN GRIA2

HGF Signaling 5.10E-01 8.70E-03 NaN IL6 HIF1α Signaling 5.01E-01 8.47E-03 NaN MMP12 Neuroprotective Role of THOP1 in Alzheimer's Disease

4.98E-01 8.40E-03 NaN PDYN

Synaptic Long Term Potentiation 4.89E-01 8.20E-03 NaN GRIA2 iCOS-iCOSL Signaling in T Helper Cells 4.86E-01 8.13E-03 NaN PLEKHA1

PI3K Signaling in B Lymphocytes 4.67E-01 7.69E-03 NaN PLEKHA1 Corticotropin Releasing Hormone Signaling

4.43E-01 7.19E-03 NaN Gucy2d

IL-12 Signaling and Production in Macrophages

4.26E-01 6.85E-03 NaN S100A8

Relaxin Signaling 4.02E-01 6.37E-03 NaN Gucy2d NF-κB Signaling 3.55E-01 5.52E-03 NaN IL1RN Production of Nitric Oxide and Reactive Oxygen Species in Macrophages

3.33E-01 5.15E-03 NaN S100A8

Clathrin-mediated Endocytosis Signaling 3.25E-01 5.03E-03 NaN S100A8 Leukocyte Extravasation Signaling 3.07E-01 4.74E-03 NaN MMP12 CREB Signaling in Neurons 3.06E-01 4.72E-03 NaN GRIA2 Cardiac Hypertrophy Signaling 2.74E-01 4.24E-03 NaN IL6 Opioid Signaling Pathway 2.66E-01 4.13E-03 NaN PDYN

4 days Ingenuity Canonical Pathways −log(P value) Ratio z-score Molecules Communication between Innate and Adaptive Immune Cells

5.26E+00 5.32E-02 NaN IL1A, IL1RN, IL6, CD8A, Ccl9

Granulocyte Adhesion and Diapedesis 5.06E+00 3.35E-02 NaN IL1A, MMP7, IL1RN, CCL20, MMP12, Ccl9

Agranulocyte Adhesion and Diapedesis 4.90E+00 3.14E-02 NaN IL1A, MMP7, IL1RN, CCL20, MMP12, Ccl9

LPS/IL-1 Mediated Inhibition of RXR Function

4.53E+00 2.70E-02 NaN IL1A, SLC27A2, IL1RN, Sult1c2 (includes others), GSTA1, ABCA1

IL-10 Signaling 4.44E+00 5.80E-02 NaN IL1A, IL1RN, IL6, MAPK13 Altered T Cell and B Cell Signaling in Rheumatoid Arthritis

3.99E+00 4.44E-02 NaN IL1A, TNFSF11, IL1RN, IL6

Xenobiotic Metabolism Signaling 3.89E+00 2.07E-02 NaN CYP1A1, IL1A, Sult1c2 (includes others), GSTA1, IL6, MAPK13

Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza

3.67E+00 6.98E-02 NaN IL1A, IL1RN, IL6

Hematopoiesis from Pluripotent Stem Cells 3.56E+00 6.38E-02 NaN IL1A, IL6, CD8A Graft-versus-Host Disease Signaling 3.53E+00 6.25E-02 NaN IL1A, IL1RN, IL6 LXR/RXR Activation 3.49E+00 3.31E-02 -2 IL1A, IL1RN, IL6, ABCA1 IL-6 Signaling 3.40E+00 3.12E-02 2 IL1A, IL1RN, IL6, MAPK13 Role of Cytokines in Mediating Communication between Immune Cells

3.38E+00 5.56E-02 NaN IL1A, IL1RN, IL6

Aryl Hydrocarbon Receptor Signaling 3.24E+00 2.84E-02 NaN CYP1A1, IL1A, GSTA1, IL6 Toll-like Receptor Signaling 2.94E+00 3.95E-02 NaN IL1A, IL1RN, MAPK13 Acute Phase Response Signaling 2.94E+00 2.35E-02 2 IL1A, IL1RN, IL6, MAPK13 IL-17A Signaling in Airway Cells 2.91E+00 3.85E-02 NaN CCL20, IL6, MAPK13 Dendritic Cell Maturation 2.74E+00 2.07E-02 2 IL1A, IL1RN, IL6, MAPK13 IL-17A Signaling in Gastric Cells 2.69E+00 8.00E-02 NaN CCL20, MAPK13 Role of JAK family kinases in IL-6-type Cytokine Signaling

2.69E+00 8.00E-02 NaN IL6, MAPK13

Cholecystokinin/Gastrin-mediated Signaling 2.59E+00 2.97E-02 NaN IL1A, IL1RN, SST Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis


HIF1α Signaling 2.40E+00 2.54E-02 NaN MMP7, MAPK13, MMP12 IL-17A Signaling in Fibroblasts 2.40E+00 5.71E-02 NaN IL6, MAPK13 p38 MAPK Signaling 2.38E+00 2.50E-02 NaN IL1A, IL1RN, MAPK13 FXR/RXR Activation 2.32E+00 2.38E-02 NaN IL1A, IL1RN, FOXA2 Atherosclerosis Signaling 2.31E+00 2.36E-02 NaN IL1A, IL1RN, IL6 Inhibition of Matrix Metalloproteases 2.30E+00 5.13E-02 NaN MMP7, MMP12 HMGB1 Signaling 2.25E+00 2.26E-02 NaN IL1A, IL6, MAPK13 Retinol Biosynthesis 2.24E+00 4.76E-02 NaN Akr1b10, LIPF Th1 Pathway 2.24E+00 2.22E-02 NaN TNFSF11, IL6, CD8A Glutathione Biosynthesis 2.09E+00 3.33E-01 NaN GCLM Hepatic Cholestasis 2.03E+00 1.88E-02 NaN IL1A, IL1RN, IL6 Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis


NF-κB Signaling 1.89E+00 1.66E-02 NaN IL1A, TNFSF11, IL1RN PXR/RXR Activation 1.88E+00 3.08E-02 NaN GSTA1, IL6 Th1 and Th2 Activation Pathway 1.86E+00 1.62E-02 NaN TNFSF11, IL6, CD8A Hepatic Fibrosis / Hepatic Stellate Cell Activation

1.85E+00 1.60E-02 NaN IL1A, IGFBP3, IL6

Role of IL-17A in Arthritis 1.83E+00 2.90E-02 NaN CCL20, MAPK13 IL-15 Signaling 1.75E+00 2.63E-02 NaN IL6, MAPK13 Aspartate Degradation II 1.73E+00 1.43E-01 NaN LIPF VDR/RXR Activation 1.73E+00 2.56E-02 NaN TNFSF11, IGFBP3 Leukocyte Extravasation Signaling 1.71E+00 1.42E-02 NaN MMP7, MAPK13, MMP12 Superoxide Radicals Degradation 1.67E+00 1.25E-01 NaN TYRP1 IL-17 Signaling 1.66E+00 2.35E-02 NaN IL6, MAPK13

Systemic Lupus Erythematosus Signaling 1.64E+00 1.33E-02 NaN IL1A, IL1RN, IL6 Bladder Cancer Signaling 1.63E+00 2.27E-02 NaN MMP7, MMP12 IL-7 Signaling Pathway 1.60E+00 2.20E-02 NaN DNTT, MAPK13 IL-1 Signaling 1.59E+00 2.17E-02 NaN IL1A, MAPK13 PPAR Signaling 1.57E+00 2.11E-02 NaN IL1A, IL1RN ErbB Signaling 1.54E+00 2.04E-02 NaN MAPK13, AREG Colorectal Cancer Metastasis Signaling 1.53E+00 1.21E-02 NaN MMP7, IL6, MMP12 RANK Signaling in Osteoclasts 1.51E+00 1.96E-02 NaN TNFSF11, MAPK13 Guanosine Nucleotides Degradation III 1.50E+00 8.33E-02 NaN ACPP Role of IL-17A in Psoriasis 1.46E+00 7.69E-02 NaN CCL20 Fatty Acid Activation 1.46E+00 7.69E-02 NaN SLC27A2 Urate Biosynthesis/Inosine 5'-phosphate Degradation

1.46E+00 7.69E-02 NaN ACPP

NAD Phosphorylation and Dephosphorylation

1.46E+00 7.69E-02 NaN ACPP

Glycogen Degradation II 1.46E+00 7.69E-02 NaN PYGM Phenylalanine Degradation IV (Mammalian, via Side Chain)

1.43E+00 7.14E-02 NaN SLC27A2

纬-glutamyl Cycle 1.43E+00 7.14E-02 NaN GCLM Glycogen Degradation III 1.40E+00 6.67E-02 NaN PYGM Granzyme B Signaling 1.37E+00 6.25E-02 NaN LMNB1 Adenosine Nucleotides Degradation II 1.37E+00 6.25E-02 NaN ACPP Parkinson's Signaling 1.37E+00 6.25E-02 NaN MAPK13 纬-linolenate Biosynthesis II (Animals) 1.35E+00 5.88E-02 NaN SLC27A2 Mitochondrial L-carnitine Shuttle Pathway 1.35E+00 5.88E-02 NaN SLC27A2

Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F

1.32E+00 5.56E-02 NaN IL6

Purine Nucleotides Degradation II (Aerobic) 1.30E+00 5.26E-02 NaN ACPP Methylglyoxal Degradation III 1.30E+00 5.26E-02 NaN Akr1b10 The Visual Cycle 1.28E+00 5.00E-02 NaN Akr1b10 Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses

1.28E+00 1.46E-02 NaN IL1A, IL6

Maturity Onset Diabetes of Young (MODY) Signaling

1.26E+00 4.76E-02 NaN FOXA2

Role of Lipids/Lipid Rafts in the Pathogenesis of Influenza

1.22E+00 4.35E-02 NaN IFNE

Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F

1.22E+00 4.35E-02 NaN IL1A

IL-22 Signaling 1.20E+00 4.17E-02 NaN MAPK13 Glutathione Redox Reactions I 1.20E+00 4.17E-02 NaN GSTA1 TCA Cycle II (Eukaryotic) 1.20E+00 4.17E-02 NaN LIPF Glucocorticoid Receptor Signaling 1.20E+00 8.85E-03 NaN IL1RN, IL6, MAPK13 Bupropion Degradation 1.19E+00 4.00E-02 NaN CYP1A1 Ethanol Degradation IV 1.19E+00 4.00E-02 NaN TYRP1 NAD Salvage Pathway II 1.17E+00 3.85E-02 NaN ACPP Gluconeogenesis I 1.17E+00 3.85E-02 NaN LIPF IL-15 Production 1.14E+00 3.57E-02 NaN IL6 Acetone Degradation I (to Methylglyoxal) 1.11E+00 3.33E-02 NaN CYP1A1

eNOS Signaling 1.10E+00 1.16E-02 NaN AQP4, CHRNA3 Glutathione-mediated Detoxification 1.10E+00 3.23E-02 NaN GSTA1 4-1BB Signaling in T Lymphocytes 1.08E+00 3.12E-02 NaN MAPK13 Fatty Acid β-oxidation I 1.08E+00 3.12E-02 NaN SLC27A2 PPARα/RXRα Activation 1.07E+00 1.11E-02 NaN IL6, ABCA1 Inhibition of Angiogenesis by TSP1 1.06E+00 2.94E-02 NaN MAPK13 Retinoate Biosynthesis I 1.06E+00 2.94E-02 NaN Akr1b10 B Cell Development 1.04E+00 2.86E-02 NaN DNTT RAR Activation 1.03E+00 1.05E-02 NaN IGFBP3, MAPK13 Complement System 1.02E+00 2.70E-02 NaN CFI NRF2-mediated Oxidative Stress Response

1.02E+00 1.04E-02 NaN GSTA1, GCLM

April Mediated Signaling 1.00E+00 2.56E-02 NaN MAPK13 Estrogen Biosynthesis 9.89E-01 2.50E-02 NaN CYP1A1 B Cell Activating Factor Signaling 9.79E-01 2.44E-02 NaN MAPK13 Mechanisms of Viral Exit from Host Cells 9.79E-01 2.44E-02 NaN LMNB1 Calcium Signaling 9.72E-01 9.71E-03 NaN TRDN, CHRNA3 UVC-Induced MAPK Signaling 9.60E-01 2.33E-02 NaN MAPK13 Serotonin Receptor Signaling 9.60E-01 2.33E-02 NaN SLC18A2 Stearate Biosynthesis I (Animals) 9.50E-01 2.27E-02 NaN SLC27A2 Role of IL-17F in Allergic Inflammatory Airway Diseases

9.41E-01 2.22E-02 NaN IL6

iNOS Signaling 9.41E-01 2.22E-02 NaN MAPK13 AMPK Signaling 9.38E-01 9.26E-03 NaN MAPK13, CHRNA3

Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency

9.32E-01 2.17E-02 NaN FOXA2

Dermatan Sulfate Biosynthesis (Late Stages)

9.32E-01 2.17E-02 NaN Sult1c2 (includes others)

Role of NFAT in Cardiac Hypertrophy 9.28E-01 9.13E-03 NaN IL6, MAPK13 Primary Immunodeficiency Signaling 9.15E-01 2.08E-02 NaN CD8A Chondroitin Sulfate Biosynthesis (Late Stages)


Amyloid Processing 8.90E-01 1.96E-02 NaN MAPK13 Cardiac Hypertrophy Signaling 8.76E-01 8.47E-03 NaN IL6, MAPK13 Triacylglycerol Degradation 8.75E-01 1.89E-02 NaN LIPF Nicotine Degradation III 8.60E-01 1.82E-02 NaN CYP1A1 Chondroitin Sulfate Biosynthesis 8.45E-01 1.75E-02 NaN Sult1c2 (includes others) Dermatan Sulfate Biosynthesis 8.31E-01 1.69E-02 NaN Sult1c2 (includes others) Retinoic acid Mediated Apoptosis Signaling 8.12E-01 1.61E-02 NaN IFNE Activation of IRF by Cytosolic Pattern Recognition Receptors

8.05E-01 1.59E-02 NaN IL6

Melatonin Degradation I 7.99E-01 1.56E-02 NaN CYP1A1 Nicotine Degradation II 7.99E-01 1.56E-02 NaN CYP1A1 UVB-Induced MAPK Signaling 7.87E-01 1.52E-02 NaN MAPK13 EGF Signaling 7.75E-01 1.47E-02 NaN MAPK13 Superpathway of Melatonin Degradation 7.69E-01 1.45E-02 NaN CYP1A1 Chemokine Signaling 7.58E-01 1.41E-02 NaN MAPK13 Role of MAPK Signaling in the Pathogenesis of Influenza

7.52E-01 1.39E-02 NaN MAPK13

T Helper Cell Differentiation 7.47E-01 1.37E-02 NaN IL6 GPCR-Mediated Integration of Enteroendocrine Signaling Exemplified by an L Cell

7.47E-01 1.37E-02 NaN SST

STAT3 Pathway 7.41E-01 1.35E-02 NaN MAPK13 TREM1 Signaling 7.36E-01 1.33E-02 NaN IL6 Heparan Sulfate Biosynthesis (Late Stages)


Antiproliferative Role of Somatostatin Receptor 2

7.31E-01 1.32E-02 NaN SST

BMP signaling pathway 7.31E-01 1.32E-02 NaN MAPK13 Role of Wnt/GSK-3β Signaling in the Pathogenesis of Influenza

7.26E-01 1.30E-02 NaN IFNE

Dopamine Receptor Signaling 7.26E-01 1.30E-02 NaN SLC18A2 CD40 Signaling 7.16E-01 1.27E-02 NaN MAPK13 Role of PI3K/AKT Signaling in the Pathogenesis of Influenza

7.16E-01 1.27E-02 NaN IFNE

Heparan Sulfate Biosynthesis 7.01E-01 1.22E-02 NaN Sult1c2 (includes others) JAK/Stat Signaling 6.97E-01 1.20E-02 NaN IL6 Neuroinflammation Signaling Pathway 6.89E-01 6.43E-03 NaN IL6, MAPK13 Growth Hormone Signaling 6.87E-01 1.18E-02 NaN IGFBP3 FLT3 Signaling in Hematopoietic Progenitor Cells

6.83E-01 1.16E-02 NaN MAPK13

α-Adrenergic Signaling 6.78E-01 1.15E-02 NaN PYGM LPS-stimulated MAPK Signaling 6.78E-01 1.15E-02 NaN MAPK13

PEDF Signaling 6.78E-01 1.15E-02 NaN MAPK13 TGF-β Signaling 6.78E-01 1.15E-02 NaN MAPK13 Neuregulin Signaling 6.74E-01 1.14E-02 NaN AREG HER-2 Signaling in Breast Cancer 6.74E-01 1.14E-02 NaN AREG Crosstalk between Dendritic Cells and Natural Killer Cells

6.70E-01 1.12E-02 NaN IL6

FGF Signaling 6.61E-01 1.10E-02 NaN MAPK13 CCR5 Signaling in Macrophages 6.45E-01 1.05E-02 NaN MAPK13 TR/RXR Activation 6.33E-01 1.02E-02 NaN TRH Melanocyte Development and Pigmentation Signaling

6.33E-01 1.02E-02 NaN TYRP1

ATM Signaling 6.33E-01 1.02E-02 NaN MAPK13 CTLA4 Signaling in Cytotoxic T Lymphocytes

6.29E-01 1.01E-02 NaN CD8A

CDK5 Signaling 6.29E-01 1.01E-02 NaN MAPK13 Mouse Embryonic Stem Cell Pluripotency 6.03E-01 9.43E-03 NaN MAPK13 UVA-Induced MAPK Signaling 6.03E-01 9.43E-03 NaN MAPK13 IGF-1 Signaling 6.03E-01 9.43E-03 NaN IGFBP3 Antioxidant Action of Vitamin C 5.96E-01 9.26E-03 NaN MAPK13 T Cell Receptor Signaling 5.93E-01 9.17E-03 NaN CD8A Type I Diabetes Mellitus Signaling 5.86E-01 9.01E-03 NaN MAPK13 Paxillin Signaling 5.79E-01 8.85E-03 NaN MAPK13 HGF Signaling 5.73E-01 8.70E-03 NaN IL6 Fc Epsilon RI Signaling 5.60E-01 8.40E-03 NaN MAPK13

Neuroprotective Role of THOP1 in Alzheimer's Disease

5.60E-01 8.40E-03 NaN SST

Renin-Angiotensin Signaling 5.51E-01 8.20E-03 NaN MAPK13 Role of Tissue Factor in Cancer 5.48E-01 8.13E-03 NaN MAPK13 CCR3 Signaling in Eosinophils 5.28E-01 7.69E-03 NaN MAPK13 Corticotropin Releasing Hormone Signaling 5.03E-01 7.19E-03 NaN MAPK13 Ovarian Cancer Signaling 4.91E-01 6.94E-03 NaN MMP7 IL-12 Signaling and Production in Macrophages

4.86E-01 6.85E-03 NaN MAPK13

Phagosome Maturation 4.81E-01 6.76E-03 NaN ATP6V0D2 Type II Diabetes Mellitus Signaling 4.67E-01 6.49E-03 NaN SLC27A2 Regulation of eIF4 and p70S6K Signaling 4.60E-01 6.37E-03 NaN MAPK13 GNRH Signaling 4.43E-01 6.06E-03 NaN MAPK13 Cdc42 Signaling 4.39E-01 5.99E-03 NaN MAPK13 Wnt/β-catenin Signaling 4.29E-01 5.81E-03 NaN MMP7 Sertoli Cell-Sertoli Cell Junction Signaling 4.17E-01 5.62E-03 NaN MAPK13 Endothelin-1 Signaling 3.95E-01 5.26E-03 NaN MAPK13 B Cell Receptor Signaling 3.93E-01 5.24E-03 NaN MAPK13 Production of Nitric Oxide and Reactive Oxygen Species in Macrophages

3.88E-01 5.15E-03 NaN MAPK13

Thrombin Signaling 3.72E-01 4.90E-03 NaN MAPK13 Osteoarthritis Pathway 3.59E-01 4.72E-03 NaN MMP12 Sirtuin Signaling Pathway 2.61E-01 3.42E-03 NaN ABCA1

7 days Ingenuity Canonical Pathways −log(P value) Ratio z-score Molecules Communication between Innate and Adaptive Immune Cells

4.66E+00 5.32E-02 NaN IFNG, IL1RN, IL6, CD8A, Ccl9


3.52E+00 4.44E-02 NaN IFNG, TNFSF11, IL1RN, IL6

Granulocyte Adhesion and Diapedesis 3.35E+00 2.79E-02 NaN MMP7, CXCL11, IL1RN, MMP12, Ccl9 Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza

3.31E+00 6.98E-02 NaN IFNG, IL1RN, IL6

Agranulocyte Adhesion and Diapedesis 3.22E+00 2.62E-02 NaN MMP7, CXCL11, IL1RN, MMP12, Ccl9 Graft-versus-Host Disease Signaling 3.17E+00 6.25E-02 NaN IFNG, IL1RN, IL6 Role of Cytokines in Mediating Communication between Immune Cells

3.02E+00 5.56E-02 NaN IFNG, IL1RN, IL6

LPS/IL-1 Mediated Inhibition of RXR Function 2.92E+00 2.25E-02 NaN FMO2, SLC27A2, IL1RN, GSTA1, FABP9 Th1 Pathway 2.86E+00 2.96E-02 NaN IFNG, TNFSF11, IL6, CD8A Role of Lipids/Lipid Rafts in the Pathogenesis of Influenza

2.52E+00 8.70E-02 NaN IFNG, IFNE

eNOS Signaling 2.48E+00 2.33E-02 NaN LPAR4, AQP4, CNGA1, CHRNA3 Xenobiotic Metabolism Signaling 2.42E+00 1.72E-02 NaN CYP1A1, CAMK2A, FMO2, GSTA1, IL6 Crosstalk between Dendritic Cells and Natural Killer Cells

2.40E+00 3.37E-02 NaN IFNG, CAMK2A, IL6

Th1 and Th2 Activation Pathway 2.36E+00 2.16E-02 NaN IFNG, TNFSF11, IL6, CD8A Inhibition of Matrix Metalloproteases 2.07E+00 5.13E-02 NaN MMP7, MMP12


2.01E+00 1.72E-02 NaN IFNG, TNFSF11, IL1RN, IL6

Atherosclerosis Signaling 1.98E+00 2.36E-02 NaN IFNG, IL1RN, IL6 Colorectal Cancer Metastasis Signaling 1.92E+00 1.61E-02 2 IFNG, MMP7, IL6, MMP12 Hematopoiesis from Pluripotent Stem Cells 1.91E+00 4.26E-02 NaN IL6, CD8A Aryl Hydrocarbon Receptor Signaling 1.85E+00 2.13E-02 NaN CYP1A1, GSTA1, IL6 Hepatic Cholestasis 1.71E+00 1.88E-02 NaN IFNG, IL1RN, IL6 Retinoic acid Mediated Apoptosis Signaling 1.68E+00 3.23E-02 NaN IFNG, IFNE Nicotine Degradation II 1.66E+00 3.12E-02 NaN CYP1A1, FMO2 PXR/RXR Activation 1.65E+00 3.08E-02 NaN GSTA1, IL6 Ceramide Biosynthesis 1.61E+00 1.43E-01 NaN SPTSSB IL-10 Signaling 1.60E+00 2.90E-02 NaN IL1RN, IL6 Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis

1.60E+00 1.28E-02 NaN TNFSF11, CAMK2A, IL1RN, IL6

T Helper Cell Differentiation 1.55E+00 2.74E-02 NaN IFNG, IL6 GPCR-Mediated Integration of Enteroendocrine Signaling Exemplified by an L Cell

1.55E+00 2.74E-02 NaN SST, GRP

TREM1 Signaling 1.53E+00 2.67E-02 NaN NLRP4, IL6 Antiproliferative Role of Somatostatin Receptor 2 1.52E+00 2.63E-02 NaN Gucy2d, SST Role of Wnt/GSK-3β Signaling in the Pathogenesis of Influenza


Pathogenesis of Multiple Sclerosis 1.50E+00 1.11E-01 NaN CXCL11 VDR/RXR Activation 1.50E+00 2.56E-02 NaN IFNG, TNFSF11 Role of PI3K/AKT Signaling in the Pathogenesis of Influenza


Calcium Transport I 1.45E+00 1.00E-01 NaN ATP2B2 IL-17 Signaling 1.43E+00 2.35E-02 NaN CXCL11, IL6 Calcium Signaling 1.43E+00 1.46E-02 NaN CAMK2A, CHRNA3, ATP2B2 α-Adrenergic Signaling 1.41E+00 2.30E-02 NaN PYGM, ADRA1A Bladder Cancer Signaling 1.40E+00 2.27E-02 NaN MMP7, MMP12 Fatty Acid Activation 1.34E+00 7.69E-02 NaN SLC27A2 Glycogen Degradation II 1.34E+00 7.69E-02 NaN PYGM cAMP-mediated signaling 1.32E+00 1.32E-02 NaN GRM7, CAMK2A, CNGA1 Phenylalanine Degradation IV (Mammalian, via Side Chain)

1.31E+00 7.14E-02 NaN SLC27A2

Cholecystokinin/Gastrin-mediated Signaling 1.30E+00 1.98E-02 NaN IL1RN, SST Glycogen Degradation III 1.28E+00 6.67E-02 NaN PYGM Granzyme B Signaling 1.26E+00 6.25E-02 NaN LMNB1 γ-linolenate Biosynthesis II (Animals) 1.23E+00 5.88E-02 NaN SLC27A2 Mitochondrial L-carnitine Shuttle Pathway 1.23E+00 5.88E-02 NaN SLC27A2 Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F

1.21E+00 5.56E-02 NaN IL6

Neuropathic Pain Signaling In Dorsal Horn Neurons

1.20E+00 1.74E-02 NaN GRM7, CAMK2A

Methylglyoxal Degradation III 1.18E+00 5.26E-02 NaN Akr1b10 HIF1α Signaling 1.18E+00 1.69E-02 NaN MMP7, MMP12 Neuroprotective Role of THOP1 in Alzheimer's Disease

1.17E+00 1.68E-02 NaN IFNG, SST

The Visual Cycle 1.16E+00 5.00E-02 NaN Akr1b10

LXR/RXR Activation 1.16E+00 1.65E-02 NaN IL1RN, IL6 Synaptic Long Term Potentiation 1.15E+00 1.64E-02 NaN GRM7, CAMK2A Maturity Onset Diabetes of Young (MODY) Signaling

1.14E+00 4.76E-02 NaN FOXA2

FXR/RXR Activation 1.13E+00 1.59E-02 NaN IL1RN, FOXA2 G-Protein Coupled Receptor Signaling 1.12E+00 1.09E-02 NaN GRM7, CAMK2A, ADRA1A IL-6 Signaling 1.12E+00 1.56E-02 NaN IL1RN, IL6 Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F

1.10E+00 4.35E-02 NaN IFNG

HMGB1 Signaling 1.09E+00 1.50E-02 NaN IFNG, IL6 Role of JAK1, JAK2 and TYK2 in Interferon Signaling

1.09E+00 4.17E-02 NaN IFNG

Glutathione Redox Reactions I 1.09E+00 4.17E-02 NaN GSTA1 IL-17A Signaling in Gastric Cells 1.07E+00 4.00E-02 NaN CXCL11 Role of JAK family kinases in IL-6-type Cytokine Signaling

1.07E+00 4.00E-02 NaN IL6

Bupropion Degradation 1.07E+00 4.00E-02 NaN CYP1A1 Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses

1.07E+00 1.46E-02 NaN IFNG, IL6

IL-15 Production 1.02E+00 3.57E-02 NaN IL6 Acetone Degradation I (to Methylglyoxal) 9.93E-01 3.33E-02 NaN CYP1A1 Glutathione-mediated Detoxification 9.79E-01 3.23E-02 NaN GSTA1 Fatty Acid β-oxidation I 9.66E-01 3.12E-02 NaN SLC27A2 Retinoate Biosynthesis I 9.42E-01 2.94E-02 NaN Akr1b10 IL-17A Signaling in Fibroblasts 9.30E-01 2.86E-02 NaN IL6

Glucocorticoid Receptor Signaling 9.18E-01 8.85E-03 NaN IFNG, IL1RN, IL6 Interferon Signaling 9.18E-01 2.78E-02 NaN IFNG Acute Phase Response Signaling 9.10E-01 1.18E-02 NaN IL1RN, IL6 Complement System 9.07E-01 2.70E-02 NaN CFI Antigen Presentation Pathway 8.96E-01 2.63E-02 NaN IFNG Synaptic Long Term Depression 8.93E-01 1.15E-02 NaN GRM7, Gucy2d Estrogen Biosynthesis 8.75E-01 2.50E-02 NaN CYP1A1 NF-κB Signaling 8.66E-01 1.10E-02 NaN TNFSF11, IL1RN Role of PKR in Interferon Induction and Antiviral Response

8.65E-01 2.44E-02 NaN IFNG

Mechanisms of Viral Exit from Host Cells 8.65E-01 2.44E-02 NaN LMNB1 Retinol Biosynthesis 8.56E-01 2.38E-02 NaN Akr1b10 Serotonin Receptor Signaling 8.46E-01 2.33E-02 NaN SLC18A2 Hepatic Fibrosis / Hepatic Stellate Cell Activation 8.43E-01 1.07E-02 NaN IFNG, IL6 Stearate Biosynthesis I (Animals) 8.37E-01 2.27E-02 NaN SLC27A2 Role of IL-17F in Allergic Inflammatory Airway Diseases

8.28E-01 2.22E-02 NaN IL6

iNOS Signaling 8.28E-01 2.22E-02 NaN IFNG Dendritic Cell Maturation 8.21E-01 1.04E-02 NaN IL1RN, IL6 Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency

8.19E-01 2.17E-02 NaN FOXA2

nNOS Signaling in Neurons 8.11E-01 2.13E-02 NaN CAMK2A Primary Immunodeficiency Signaling 8.02E-01 2.08E-02 NaN CD8A Protein Kinase A Signaling 7.66E-01 7.50E-03 NaN CAMK2A, PYGM, CNGA1 Semaphorin Signaling in Neurons 7.63E-01 1.89E-02 NaN NRP1

Phototransduction Pathway 7.63E-01 1.89E-02 NaN CNGA1 Leukocyte Extravasation Signaling 7.61E-01 9.48E-03 NaN MMP7, MMP12 CREB Signaling in Neurons 7.57E-01 9.43E-03 NaN GRM7, CAMK2A Nicotine Degradation III 7.48E-01 1.82E-02 NaN CYP1A1 AMPK Signaling 7.45E-01 9.26E-03 NaN CHRNA3, ADRA1A Role of NFAT in Cardiac Hypertrophy 7.36E-01 9.13E-03 NaN CAMK2A, IL6 Regulation of Cellular Mechanics by Calpain Protease

7.34E-01 1.75E-02 NaN CNGA1

Glutamate Receptor Signaling 7.34E-01 1.75E-02 NaN GRM7 Systemic Lupus Erythematosus Signaling 7.18E-01 8.89E-03 NaN IL1RN, IL6 autophagy 7.01E-01 1.61E-02 NaN CTSW Activation of IRF by Cytosolic Pattern Recognition Receptors

6.95E-01 1.59E-02 NaN IL6

Wnt/Ca+ pathway 6.95E-01 1.59E-02 NaN CAMK2A Melatonin Degradation I 6.89E-01 1.56E-02 NaN CYP1A1 Cardiac Hypertrophy Signaling 6.87E-01 8.47E-03 NaN IL6, ADRA1A Superpathway of Melatonin Degradation 6.60E-01 1.45E-02 NaN CYP1A1 Chemokine Signaling 6.49E-01 1.41E-02 NaN CAMK2A Melatonin Signaling 6.44E-01 1.39E-02 NaN CAMK2A Role of MAPK Signaling in the Pathogenesis of Influenza

6.44E-01 1.39E-02 NaN IFNG

MSP-RON Signaling Pathway 6.44E-01 1.39E-02 NaN IFNG GM-CSF Signaling 6.39E-01 1.37E-02 NaN CAMK2A IL-15 Signaling 6.23E-01 1.32E-02 NaN IL6 Toll-like Receptor Signaling 6.23E-01 1.32E-02 NaN IL1RN

Dopamine Receptor Signaling 6.18E-01 1.30E-02 NaN SLC18A2 IL-17A Signaling in Airway Cells 6.14E-01 1.28E-02 NaN IL6 Role of BRCA1 in DNA Damage Response 6.04E-01 1.25E-02 NaN IFNG JAK/Stat Signaling 5.90E-01 1.20E-02 NaN IL6 Allograft Rejection Signaling 5.86E-01 1.19E-02 NaN IFNG Neuregulin Signaling 5.68E-01 1.14E-02 NaN AREG HER-2 Signaling in Breast Cancer 5.68E-01 1.14E-02 NaN AREG VEGF Family Ligand-Receptor Interactions 5.68E-01 1.14E-02 NaN NRP1 IL-7 Signaling Pathway 5.56E-01 1.10E-02 NaN IFNG PPAR Signaling 5.40E-01 1.05E-02 NaN IL1RN TR/RXR Activation 5.29E-01 1.02E-02 NaN TRH ErbB Signaling 5.29E-01 1.02E-02 NaN AREG CTLA4 Signaling in Cytotoxic T Lymphocytes 5.25E-01 1.01E-02 NaN CD8A Neuroinflammation Signaling Pathway 5.16E-01 6.43E-03 NaN IFNG, IL6 RANK Signaling in Osteoclasts 5.14E-01 9.80E-03 NaN TNFSF11 IGF-1 Signaling 5.01E-01 9.43E-03 NaN IGFBP2 T Cell Receptor Signaling 4.91E-01 9.17E-03 NaN CD8A Gαs Signaling 4.87E-01 9.09E-03 NaN CNGA1 Type I Diabetes Mellitus Signaling 4.84E-01 9.01E-03 NaN IFNG Glioma Signaling 4.75E-01 8.77E-03 NaN CAMK2A HGF Signaling 4.72E-01 8.70E-03 NaN IL6 Gαi Signaling 4.57E-01 8.33E-03 NaN GRM7 p38 MAPK Signaling 4.57E-01 8.33E-03 NaN IL1RN iCOS-iCOSL Signaling in T Helper Cells 4.48E-01 8.13E-03 NaN CAMK2A RhoA Signaling 4.45E-01 8.06E-03 NaN LPAR4

Sperm Motility 4.37E-01 7.87E-03 NaN CNGA1 PI3K Signaling in B Lymphocytes 4.29E-01 7.69E-03 NaN CAMK2A Gα12/13 Signaling 4.16E-01 7.41E-03 NaN LPAR4 Corticotropin Releasing Hormone Signaling 4.06E-01 7.19E-03 NaN Gucy2d Ovarian Cancer Signaling 3.95E-01 6.94E-03 NaN MMP7 IL-12 Signaling and Production in Macrophages 3.90E-01 6.85E-03 NaN IFNG Molecular Mechanisms of Cancer 3.86E-01 5.08E-03 NaN RASGRF1, CAMK2A Phagosome Maturation 3.86E-01 6.76E-03 NaN CTSW Th2 Pathway 3.81E-01 6.67E-03 NaN IFNG Gustation Pathway 3.75E-01 6.54E-03 NaN LPAR4 Type II Diabetes Mellitus Signaling 3.73E-01 6.49E-03 NaN SLC27A2 Relaxin Signaling 3.66E-01 6.37E-03 NaN Gucy2d PKCθ Signaling in T Lymphocytes 3.62E-01 6.29E-03 NaN CAMK2A Gαq Signaling 3.58E-01 6.21E-03 NaN ADRA1A GNRH Signaling 3.50E-01 6.06E-03 NaN CAMK2A Wnt/β-catenin Signaling 3.37E-01 5.81E-03 NaN MMP7 PPARα/RXRα Activation 3.23E-01 5.56E-03 NaN IL6 Axonal Guidance Signaling 3.18E-01 4.42E-03 NaN MMP7, NRP1 B Cell Receptor Signaling 3.05E-01 5.24E-03 NaN CAMK2A NRF2-mediated Oxidative Stress Response 3.01E-01 5.18E-03 NaN GSTA1 Production of Nitric Oxide and Reactive Oxygen Species in Macrophages

3.00E-01 5.15E-03 NaN IFNG

Gap Junction Signaling 2.98E-01 5.13E-03 NaN Gucy2d Clathrin-mediated Endocytosis Signaling 2.92E-01 5.03E-03 NaN SNAP91 Thrombin Signaling 2.85E-01 4.90E-03 NaN CAMK2A

Breast Cancer Regulation by Stathmin1 2.83E-01 4.88E-03 NaN CAMK2A Osteoarthritis Pathway 2.74E-01 4.72E-03 NaN MMP12 Opioid Signaling Pathway 2.36E-01 4.13E-03 NaN CAMK2A Protein Ubiquitination Pathway 2.12E-01 3.77E-03 NaN IFNG

14 days Ingenuity Canonical Pathways −log(P value) Ratio z-score Molecules Neuroprotective Role of THOP1 in Alzheimer's Disease

3.64E+00 3.36E-02 NaN IFNG, PDYN, SST, KLK10


2.82E+00 3.33E-02 NaN IFNG, TNFSF11, IL6


2.77E+00 3.19E-02 NaN IFNG, IL6, Ccl9


2.55E+00 1.72E-02 NaN IFNG, TNFSF11, IL6, BMP6

Atherosclerosis Signaling 2.40E+00 2.36E-02 NaN IFNG, ALB, IL6 Th1 Pathway 2.32E+00 2.22E-02 NaN IFNG, TNFSF11, IL6 Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza

2.28E+00 4.65E-02 NaN IFNG, IL6

Aryl Hydrocarbon Receptor Signaling 2.27E+00 2.13E-02 NaN CYP1A1, GSTA1, IL6 Xenobiotic Metabolism Signaling 2.22E+00 1.38E-02 NaN CYP1A1, GSTA1, IL6, PPP2R5E Graft-versus-Host Disease Signaling 2.19E+00 4.17E-02 NaN IFNG, IL6

Role of Cytokines in Mediating Communication between Immune Cells

2.09E+00 3.70E-02 NaN IFNG, IL6

Synaptic Long Term Depression 2.02E+00 1.72E-02 NaN GRM8, Gucy2d, PPP2R5E Th1 and Th2 Activation Pathway 1.95E+00 1.62E-02 NaN IFNG, TNFSF11, IL6 PXR/RXR Activation 1.93E+00 3.08E-02 NaN GSTA1, IL6 Lysine Degradation II 1.90E+00 2.00E-01 NaN AADAT Lysine Degradation V 1.90E+00 2.00E-01 NaN AADAT Production of Nitric Oxide and Reactive Oxygen Species in Macrophages

1.89E+00 1.55E-02 NaN IFNG, ALB, PPP2R5E

MSP-RON Signaling Pathway 1.85E+00 2.78E-02 NaN IFNG, KLK10 T Helper Cell Differentiation 1.84E+00 2.74E-02 NaN IFNG, IL6 Antiproliferative Role of Somatostatin Receptor 2 1.80E+00 2.63E-02 NaN Gucy2d, SST Dopamine Receptor Signaling 1.79E+00 2.60E-02 NaN PPP2R5E, SLC18A2 VDR/RXR Activation 1.78E+00 2.56E-02 NaN IFNG, TNFSF11 LPS/IL-1 Mediated Inhibition of RXR Function 1.74E+00 1.35E-02 NaN SLC27A2, GSTA1, FABP9 Crosstalk between Dendritic Cells and Natural Killer Cells

1.68E+00 2.25E-02 NaN IFNG, IL6

Colorectal Cancer Metastasis Signaling 1.61E+00 1.21E-02 NaN IFNG, IL6, MMP12 Calcium Transport I 1.60E+00 1.00E-01 NaN ATP2B2 Fatty Acid Activation 1.49E+00 7.69E-02 NaN SLC27A2 Phenylalanine Degradation IV (Mammalian, via Side Chain)

1.46E+00 7.14E-02 NaN SLC27A2

LXR/RXR Activation 1.43E+00 1.65E-02 NaN ALB, IL6 Granzyme B Signaling 1.40E+00 6.25E-02 NaN LMNB1 γ-linolenate Biosynthesis II (Animals) 1.38E+00 5.88E-02 NaN SLC27A2

Mitochondrial L-carnitine Shuttle Pathway 1.38E+00 5.88E-02 NaN SLC27A2 HMGB1 Signaling 1.35E+00 1.50E-02 NaN IFNG, IL6 Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F

1.35E+00 5.56E-02 NaN IL6

Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses

1.33E+00 1.46E-02 NaN IFNG, IL6

IL-12 Signaling and Production in Macrophages 1.28E+00 1.37E-02 NaN IFNG, ALB Role of Lipids/Lipid Rafts in the Pathogenesis of Influenza

1.25E+00 4.35E-02 NaN IFNG

Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F

1.25E+00 4.35E-02 NaN IFNG

Role of JAK1, JAK2 and TYK2 in Interferon Signaling

1.23E+00 4.17E-02 NaN IFNG

Glutathione Redox Reactions I 1.23E+00 4.17E-02 NaN GSTA1 Role of JAK family kinases in IL-6-type Cytokine Signaling

1.21E+00 4.00E-02 NaN IL6

Bupropion Degradation 1.21E+00 4.00E-02 NaN CYP1A1 Hepatic Cholestasis 1.21E+00 1.25E-02 NaN IFNG, IL6 IL-15 Production 1.17E+00 3.57E-02 NaN IL6 Acute Phase Response Signaling 1.17E+00 1.18E-02 NaN ALB, IL6 Acetone Degradation I (to Methylglyoxal) 1.14E+00 3.33E-02 NaN CYP1A1 Granulocyte Adhesion and Diapedesis 1.13E+00 1.12E-02 NaN MMP12, Ccl9 Glutathione-mediated Detoxification 1.12E+00 3.23E-02 NaN GSTA1 Fatty Acid β-oxidation I 1.11E+00 3.12E-02 NaN SLC27A2

Hepatic Fibrosis / Hepatic Stellate Cell Activation 1.09E+00 1.07E-02 NaN IFNG, IL6 Agranulocyte Adhesion and Diapedesis 1.08E+00 1.05E-02 NaN MMP12, Ccl9 IL-17A Signaling in Fibroblasts 1.07E+00 2.86E-02 NaN IL6 Interferon Signaling 1.06E+00 2.78E-02 NaN IFNG Cell Cycle Regulation by BTG Family Proteins 1.05E+00 2.70E-02 NaN PPP2R5E Complement System 1.05E+00 2.70E-02 NaN CFI Antigen Presentation Pathway 1.04E+00 2.63E-02 NaN IFNG Inhibition of Matrix Metalloproteases 1.03E+00 2.56E-02 NaN MMP12 Estrogen Biosynthesis 1.02E+00 2.50E-02 NaN CYP1A1 Role of PKR in Interferon Induction and Antiviral Response

1.01E+00 2.44E-02 NaN IFNG

Mechanisms of Viral Exit from Host Cells 1.01E+00 2.44E-02 NaN LMNB1 Intrinsic Prothrombin Activation Pathway 9.98E-01 2.38E-02 NaN KLK10 Serotonin Receptor Signaling 9.89E-01 2.33E-02 NaN SLC18A2 Stearate Biosynthesis I (Animals) 9.79E-01 2.27E-02 NaN SLC27A2 Role of IL-17F in Allergic Inflammatory Airway Diseases

9.70E-01 2.22E-02 NaN IL6

iNOS Signaling 9.70E-01 2.22E-02 NaN IFNG Hematopoiesis from Pluripotent Stem Cells 9.52E-01 2.13E-02 NaN IL6 Semaphorin Signaling in Neurons 9.03E-01 1.89E-02 NaN NRP1 Nicotine Degradation III 8.88E-01 1.82E-02 NaN CYP1A1 Role of CHK Proteins in Cell Cycle Checkpoint Control

8.74E-01 1.75E-02 NaN PPP2R5E

Glutamate Receptor Signaling 8.74E-01 1.75E-02 NaN GRM8 Retinoic acid Mediated Apoptosis Signaling 8.40E-01 1.61E-02 NaN IFNG

autophagy 8.40E-01 1.61E-02 NaN CTSW Activation of IRF by Cytosolic Pattern Recognition Receptors

8.33E-01 1.59E-02 NaN IL6

Melatonin Degradation I 8.27E-01 1.56E-02 NaN CYP1A1 Nicotine Degradation II 8.27E-01 1.56E-02 NaN CYP1A1 Mitotic Roles of Polo-Like Kinase 8.15E-01 1.52E-02 NaN PPP2R5E IL-10 Signaling 7.97E-01 1.45E-02 NaN IL6 Superpathway of Melatonin Degradation 7.97E-01 1.45E-02 NaN CYP1A1 Caveolar-mediated Endocytosis Signaling 7.86E-01 1.41E-02 NaN ALB Basal Cell Carcinoma Signaling 7.80E-01 1.39E-02 NaN BMP6 Role of MAPK Signaling in the Pathogenesis of Influenza

7.80E-01 1.39E-02 NaN IFNG

GPCR-Mediated Integration of Enteroendocrine Signaling Exemplified by an L Cell

7.74E-01 1.37E-02 NaN SST

TREM1 Signaling 7.64E-01 1.33E-02 NaN IL6 IL-15 Signaling 7.59E-01 1.32E-02 NaN IL6 BMP signaling pathway 7.59E-01 1.32E-02 NaN BMP6 Role of Wnt/GSK-3β Signaling in the Pathogenesis of Influenza

7.53E-01 1.30E-02 NaN IFNG

IL-17A Signaling in Airway Cells 7.48E-01 1.28E-02 NaN IL6 Role of PI3K/AKT Signaling in the Pathogenesis of Influenza

7.43E-01 1.27E-02 NaN IFNG

Role of BRCA1 in DNA Damage Response 7.38E-01 1.25E-02 NaN IFNG Cyclins and Cell Cycle Regulation 7.38E-01 1.25E-02 NaN PPP2R5E Neuroinflammation Signaling Pathway 7.35E-01 6.43E-03 NaN IFNG, IL6

Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis

7.33E-01 6.41E-03 NaN TNFSF11, IL6

JAK/Stat Signaling 7.24E-01 1.20E-02 NaN IL6 Allograft Rejection Signaling 7.19E-01 1.19E-02 NaN IFNG IL-17 Signaling 7.15E-01 1.18E-02 NaN IL6 HIPPO signaling 7.06E-01 1.15E-02 NaN PPP2R5E Bladder Cancer Signaling 7.01E-01 1.14E-02 NaN MMP12 VEGF Family Ligand-Receptor Interactions 7.01E-01 1.14E-02 NaN NRP1 IL-7 Signaling Pathway 6.88E-01 1.10E-02 NaN IFNG Factors Promoting Cardiogenesis in Vertebrates 6.84E-01 1.09E-02 NaN BMP6 Ceramide Signaling 6.80E-01 1.08E-02 NaN PPP2R5E Glucocorticoid Receptor Signaling 6.79E-01 5.90E-03 NaN IFNG, IL6 TR/RXR Activation 6.60E-01 1.02E-02 NaN TRH ATM Signaling 6.60E-01 1.02E-02 NaN PPP2R5E CTLA4 Signaling in Cytotoxic T Lymphocytes 6.56E-01 1.01E-02 NaN PPP2R5E CDK5 Signaling 6.56E-01 1.01E-02 NaN PPP2R5E Cholecystokinin/Gastrin-mediated Signaling 6.48E-01 9.90E-03 NaN SST RANK Signaling in Osteoclasts 6.44E-01 9.80E-03 NaN TNFSF11 Type I Diabetes Mellitus Signaling 6.12E-01 9.01E-03 NaN IFNG Telomerase Signaling 6.12E-01 9.01E-03 NaN PPP2R5E Neuropathic Pain Signaling In Dorsal Horn Neurons 5.99E-01 8.70E-03 NaN GRM8 HGF Signaling 5.99E-01 8.70E-03 NaN IL6 HIF1α Signaling 5.89E-01 8.47E-03 NaN MMP12 Gαi Signaling 5.83E-01 8.33E-03 NaN GRM8 Synaptic Long Term Potentiation 5.77E-01 8.20E-03 NaN GRM8

Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency

5.77E-01 8.20E-03 NaN BMP6

PI3K/AKT Signaling 5.68E-01 8.00E-03 NaN PPP2R5E FXR/RXR Activation 5.65E-01 7.94E-03 NaN ALB IL-6 Signaling 5.59E-01 7.81E-03 NaN IL6 p70S6K Signaling 5.48E-01 7.58E-03 NaN PPP2R5E Corticotropin Releasing Hormone Signaling 5.29E-01 7.19E-03 NaN Gucy2d Cardiac β-adrenergic Signaling 5.26E-01 7.14E-03 NaN PPP2R5E Human Embryonic Stem Cell Pluripotency 5.18E-01 6.99E-03 NaN BMP6 D-myo-inositol (1, 4, 5, 6)-Tetrakisphosphate Biosynthesis

5.16E-01 6.94E-03 NaN PPP2R5E

D-myo-inositol (3, 4, 5, 6)-tetrakisphosphate Biosynthesis

5.16E-01 6.94E-03 NaN PPP2R5E

Phagosome Maturation 5.06E-01 6.76E-03 NaN CTSW Axonal Guidance Signaling 5.02E-01 4.42E-03 NaN BMP6, NRP1 Th2 Pathway 5.01E-01 6.67E-03 NaN IFNG Type II Diabetes Mellitus Signaling 4.92E-01 6.49E-03 NaN SLC27A2 Relaxin Signaling 4.85E-01 6.37E-03 NaN Gucy2d Regulation of eIF4 and p70S6K Signaling 4.85E-01 6.37E-03 NaN PPP2R5E 3-phosphoinositide Degradation 4.83E-01 6.33E-03 NaN PPP2R5E D-myo-inositol-5-phosphate Metabolism 4.74E-01 6.17E-03 NaN PPP2R5E Dopamine-DARPP32 Feedback in cAMP Signaling 4.70E-01 6.10E-03 NaN PPP2R5E Tight Junction Signaling 4.63E-01 5.99E-03 NaN PPP2R5E Wnt/β-catenin Signaling 4.53E-01 5.81E-03 NaN PPP2R5E PPARα/RXRα Activation 4.37E-01 5.56E-03 NaN IL6

NF-κB Signaling 4.35E-01 5.52E-03 NaN TNFSF11 NRF2-mediated Oxidative Stress Response 4.13E-01 5.18E-03 NaN GSTA1 Dendritic Cell Maturation 4.13E-01 5.18E-03 NaN IL6 Gap Junction Signaling 4.10E-01 5.13E-03 NaN Gucy2d ILK Signaling 4.06E-01 5.08E-03 NaN PPP2R5E Clathrin-mediated Endocytosis Signaling 4.03E-01 5.03E-03 NaN ALB 3-phosphoinositide Biosynthesis 4.01E-01 5.00E-03 NaN PPP2R5E ERK/MAPK Signaling 4.01E-01 5.00E-03 NaN PPP2R5E mTOR Signaling 4.00E-01 4.98E-03 NaN PPP2R5E Breast Cancer Regulation by Stathmin1 3.93E-01 4.88E-03 NaN PPP2R5E Calcium Signaling 3.91E-01 4.85E-03 NaN ATP2B2 Leukocyte Extravasation Signaling 3.84E-01 4.74E-03 NaN MMP12 CREB Signaling in Neurons 3.82E-01 4.72E-03 NaN GRM8 Osteoarthritis Pathway 3.82E-01 4.72E-03 NaN MMP12 AMPK Signaling 3.76E-01 4.63E-03 NaN PPP2R5E Role of NFAT in Cardiac Hypertrophy 3.71E-01 4.57E-03 NaN IL6 Systemic Lupus Erythematosus Signaling 3.63E-01 4.44E-03 NaN IL6 cAMP-mediated signaling 3.60E-01 4.41E-03 NaN GRM8 Superpathway of Inositol Phosphate Compounds 3.49E-01 4.26E-03 NaN PPP2R5E Cardiac Hypertrophy Signaling 3.47E-01 4.24E-03 NaN IL6 Opioid Signaling Pathway 3.39E-01 4.13E-03 NaN PDYN Protein Ubiquitination Pathway 3.11E-01 3.77E-03 NaN IFNG G-Protein Coupled Receptor Signaling 2.99E-01 3.62E-03 NaN GRM8 Molecular Mechanisms of Cancer 1.99E-01 2.54E-03 NaN BMP6

List of canonical signaling pathways in the proximal nerve...

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