Liposomal drug delivery - an emerging trend for the treatment of tuberculosis
-
Upload
vikas-soni -
Category
Health & Medicine
-
view
69 -
download
1
Transcript of Liposomal drug delivery - an emerging trend for the treatment of tuberculosis
Neha Rai*, Richa Tripathy, Vikas Soni.
Department of pharmaceutical sciences,Dr.H.S.Gour Central University Sagar (M.P.)
INTRODUCTION
Liposomes are nano size artificial vesicles of spherical shape that can be produced
from natural phospholipids and cholesterol. Bangham discovered that phospholipids
combined with water immediately forms a bi-layered sphere, because one end of each
molecule is water soluble, while the opposite end is water insoluble.
Liposome based drug delivery system, offer the potential to
enhance therapeutic index of anti-cancer agents, either by
increasing the drug concentration in tumor cells and/or by
decreasing the exposure in normal tissue exploiting
enhanced permeability and retention effect phenomenon
and by utilizing targeting strategies.
CONCLUSION :
Formulations Active
ingredients
Applications of
liposomes
formulations
Biological activity %
entrapment
efficiency
Route of
administration
Quercetin
liposomes
Qurecetin Reduced
dose,enhance
penetration in BBB
Antioxidant
Anticancer
60% Intranasal
Liposomes
encapsulated
silymarin
Silymarin Improve
bioavailability
Hepatoprotective 69.22±
0.6%
Buccal
Curcumin liposome curcumin Long circulating Anticancer 88.27±
2.16%
In vitro
Flavonoids
liposomes
Quercetin
and rutin
Bleeding of
flavonoids with Hb
is enhanced
Hemoglobin - In vitro
Garlicin liposome Garlicin Increase efficiency Lungs 90.77% -
Catechins liposome Catechins Increased
permiation through
skin
Antioxidant &
chemopreservative
93.0±
0.1%
Transdermal
Colchicine
liposome
Colchicine Enhance skin
accumulation, prol-
-ong drug release
Antigout 66.3±
2.2%
Topical
LIPOSOMAL DRUG DELIVERY IN T.B. TREATMENT
LIPOSOMAL HERBAL FORMULATIONSDespite being an ancient disease, TB continues to be a major health
concern around the world. Pulmonary TB is the most common
manifestation of TB and the development of controlled release
formulations of anti-TB drugs that are either inhaled or intravenously
administrated and directly delivered to the lungs seems a possible
approach in the development of novel and more efficient therapeutic
alternatives. Liposomes are nanobiotechnological systems with great
potential to be applied in drug delivery for the treatment of TB. Their
use increases the therapeutic index of anti-TB drugs, and they are safe
and biocompatible. Various properties of these carriers, including size,
surface charge, composition and the presence of ligands, significantly
alter the specificity to alveolar macrophages. Therefore, liposomes
represent appealing nanocarrier systems for anti-TB drugs and possess
large potential for the treatment of pulmonary TB.
REFERENCES
METHOD OF LIPOSOME PREPARATION
BIOAVAILABILITY OF LIPOSOMES
Silymarin is poorly absorbed (20-50%) from the gastrointestinal tract but incorporation of
silymarin into liposomal dosage form administered buccally can improve its
bioavailability. The introduced hybrid liposomal silymarin formula for buccal
administration have the advantage of exerting a mucoadhesive effect .
LIPOSOME FOR DRUG
DELIVERY
1) Blumenthal M, Goldberg A, Brinkmann J. Herbal medicine. Integrative Medicine Communications. Newton; 2000. 2) Xiao YL, Li B. Chine Trad Herb Drugs 2002;33:385.
There are several methods:-
• 1) Multi-laminar vesicles:
• a) Liquid hydration method
• b) Solvent spherule method
• 2) Unilaminar vesicles:
• a) Freeze-Thaw method
• b) Micro fluidization method
• c) Reverse phase evaporation method
• d) Sanitation method
1) Liposome can carry both the hydrophobic and hydrophilic drug,
therefore, liposome as a drug carrier can indiscriminately
deliver drugs through the cell membrane.
2) Liposome herbal therapy acts as a carrier for small cytotoxic
molecules and as vehicle for macromolecules as gene.
3) Liposome formulation can produce sustained and controlled
release of formulation and enhances drug solubility.
4) Standardized plant extracts or mainly polar phytoconstituents
like flavonoids,terpenoids,tannins when administered through
liposomes show much better bioavailability.
INDUSTRIAL
METHOD
1) Detergent dialysis method
2) Microlludisation method
3) Preliposomes
4) Freeze drying method
Drug crystallized in aqueous fluid
Lipid bilayer
Lipid soluble drug in bilayer
DNA