Lipid Transport And Storage
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Transcript of Lipid Transport And Storage
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Lipid Transport and Storage
Dr. Bibi KulsoomAssistant Professor
Department of Biochemistry
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Countrywide Transport
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Structure of Small Intestine
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Structure of Small Intestine
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Triglyceride Packing & Transport
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Chylomicron
A-II
A-II
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Lymphatic system
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Blood Circulation
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A II
Chylomicron
HDLApo C II, E
B 48
E
C II
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Triacylgycerol Storage
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Triacylgycerol Storage
http://www.trudicanavan.comhttp://www.vivo.colostate.edu
Brown Adipose Tissue
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Chylomicron Transport to Liver
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Countrywide Transport
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Hepatic uptake of Chylomicron Remnants
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Fate of Chylomicron Remnants
Chol
TGFFA
PhoL
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Secretion of VLDL
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Lipoproteins
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Lipoprotein Structure
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Composition of Lipoproteins
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Lipoprotein Sources Main Lipid Apolipoproteins
Chylomicron Intestine Triacylgycerol A-I, A-II, A-IV, B-48,
C-I, C-II, C-III, E
Chylomicron
remnants
Chylomicron Triacylgycerol, Phospholipids, Cholesterol
B-48, E
VLDL Liver Triacylgycerol, Cholesterol
B-100, C-I, C-II, C-III
IDL VLDL Triacylgycerol B-100, E
LDL IDL Cholesterol B-100
HDL Liver, Intestine Phospholipids, Cholesterol
A-I, A-II, A-IV, C-I,C-II, C-III, D, E
Free fatty acids with Albumin
Adipose tissue
Free Fatty acid
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Apolipoproteins
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Apoprotein Function
ApoA-I Activates LCAT.
ApoA-II Enhanced hepatic lipase activity.
ApoA-IV Contributes to structure.
ApoB-48 Contributes to structure.
ApoB-100 Binds LDL receptor.
ApoC-I Probably activates LCAT.
ApoC-II Activates LPL.
ApoC-III Inhibits LPL.
ApoD Closely associated with LCAT.
ApoE Binds to LDL receptors.
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Triacylglycerol Transport
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Bood circulation
Harper’s Illustrated Biochemistry
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Triacylglycerol & Cholesterol Transport
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Harper’s Illustrated Biochemistry
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Reverse Cholesterol Transport
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Harper’s Illustrated Biochemistry
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Dislioproteinemias
• Hypoliproteinemias– abetalipoproteinemia
• Hyperliproteinemias– Deficiency of
• LPL
• Hepatic lipase
• LCAT
• LDL receptor
• Apo E
etc
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Suggested Reading:• Harper’s Illustrated Biochemistry, 28 Ed. McGraw-Hill.• Lehninger Principles of Biochemistry, 5 Ed. WHFreeman & Co.
Lipid Transport and Storage