Lipid Revision
-
Upload
jerry-mays -
Category
Documents
-
view
16 -
download
1
description
Transcript of Lipid Revision
![Page 1: Lipid Revision](https://reader036.fdocuments.net/reader036/viewer/2022062422/56813019550346895d959486/html5/thumbnails/1.jpg)
LipidRevision
1
![Page 2: Lipid Revision](https://reader036.fdocuments.net/reader036/viewer/2022062422/56813019550346895d959486/html5/thumbnails/2.jpg)
Hydrocarbon
H H H H H H H H H H H O H-C – C – C – C – C – C – C – C – C – C – C – C – OH H H H H H H H H H H H
OC –OH
Fatty acids = Hydrocarbon + carboxyl group
1. What is this structureFatty Acid
2. What is it composed of ?Hydrocarbon and carboxyl group
Carboxyl group
2
![Page 3: Lipid Revision](https://reader036.fdocuments.net/reader036/viewer/2022062422/56813019550346895d959486/html5/thumbnails/3.jpg)
H H H H H H H H H H H H H H H O H – C – C – C – C – C – C – C – C – C – C – C – C – C - C – C – C – OH H H H H H H H H H H H H H H H
1. Give a name for this fatty acidPalmitic acid
2. What type of fatty acid is this?
Saturated
3. Draw the structure of oleic acid H H H H H H H H H H H H H H H H H O H – C – C – C – C – C – C – C – C – C = C – C – C – C – C – C – C – C – C – OH H H H H H H H H H H H H H H H 3
![Page 4: Lipid Revision](https://reader036.fdocuments.net/reader036/viewer/2022062422/56813019550346895d959486/html5/thumbnails/4.jpg)
H H H H H H H H H H H H H H H O H – C – C – C – C – C – C – C – C – C – C – C – C – C - C – C – C – OH H H H H H H H H H H H H H H H
1. Give another way how the above fatty acid can be written
CH3(CH2)14COOH H H H H H H H H H H H H H H H H H O H – C – C – C – C – C – C – C – C – C = C – C – C – C – C – C – C – C – C – OH H H H H H H H H H H H H H H H
1. Give another way how the above fatty acid can be written
CH3(CH2)7CH=CH(CH2)7COOH 4
![Page 5: Lipid Revision](https://reader036.fdocuments.net/reader036/viewer/2022062422/56813019550346895d959486/html5/thumbnails/5.jpg)
O RC – OH
If the general formula for a fatty acid is, what is R equal to?
- R = a hydrocarbon group
H H– C – OH H– C – OH H– C – OH H
1. What is this compound?Glycerol/trihydroxy alcohol
2. Circle the hydroxyl group
5
![Page 6: Lipid Revision](https://reader036.fdocuments.net/reader036/viewer/2022062422/56813019550346895d959486/html5/thumbnails/6.jpg)
H H– C – OH H– C – OH H– C – OH H
O RC – OH
Form an ester linkage between the top C of glycerol and the fatty acid
H O H– C – O – C – R H– C – OH H– C – OH H
What is the name of the product?Monoacyglycerol
6
![Page 7: Lipid Revision](https://reader036.fdocuments.net/reader036/viewer/2022062422/56813019550346895d959486/html5/thumbnails/7.jpg)
H H– C – OH H– C – OH H– C – OH H
O RC – OH
Form an ester linkage between the top C of glycerol and the fatty acid
H H– C –OH H– C –OH H– C –OH H
What is the name of the product?Monoacyglycerol
O ll- C-R
7
![Page 8: Lipid Revision](https://reader036.fdocuments.net/reader036/viewer/2022062422/56813019550346895d959486/html5/thumbnails/8.jpg)
Similarly, form ester linkages with the remaining C’s of glycerol and two more molecules of fatty acids
H O H– C – O – C – R O H– C – O – C – R O
H– C – O – C – R H
What is the name of the product?Triacyglycerol
You have just constructed a lipid!!!!
8
![Page 9: Lipid Revision](https://reader036.fdocuments.net/reader036/viewer/2022062422/56813019550346895d959486/html5/thumbnails/9.jpg)
H H– C – O – H H– C – O – H
H– C – O – H H
O O – C – C17H33
O O – C – C17H33
Draw the structure of a lipid composed of and glycerol
O C17H33C – OH
O O – C – C17H33
What is the name of this lipid?
Tristearin
9
![Page 10: Lipid Revision](https://reader036.fdocuments.net/reader036/viewer/2022062422/56813019550346895d959486/html5/thumbnails/10.jpg)
A lipid is
H O H– C – O – C – C17H33
O H– C – O – C – C17H33 O
H– C – O – C – C17H33 H
Hydrocarbon
Hydrocarbon
Hydrocarbon
10
![Page 11: Lipid Revision](https://reader036.fdocuments.net/reader036/viewer/2022062422/56813019550346895d959486/html5/thumbnails/11.jpg)
PHOSPHOLIPIDS1. What is another name for phospholipids?
Phosphoglycerides /Phosphoglycerol
2. What are the components of phospholipids?a. Glycerolb. 2 fatty acidsc. Phosphated. alcohol
3. Draw the structures of the components of phospholipids. H H– C – OH H– C – OH H– C – OH H
O RC – OH
O – P – O-
O
– OH
11
![Page 12: Lipid Revision](https://reader036.fdocuments.net/reader036/viewer/2022062422/56813019550346895d959486/html5/thumbnails/12.jpg)
H H– C – O – H H– C – O – H
H– C – O – H H
O – C – R
O – C – R
O – P – O-
O
What is this compound?Phosphatidic Acid
How do you draw the structure of a phospholipid?
12
![Page 13: Lipid Revision](https://reader036.fdocuments.net/reader036/viewer/2022062422/56813019550346895d959486/html5/thumbnails/13.jpg)
H H– C – O – H H– C – O – H
H– C – O – H H
O – C – R O – C – R O – P – O-
O
Phosphatidic Acid
Phosphoglyceride/Phospholipids/phosphoglycerol
- R
How do you form a phospholilpid?
What is R? Glycerol or other alcohols
13
![Page 14: Lipid Revision](https://reader036.fdocuments.net/reader036/viewer/2022062422/56813019550346895d959486/html5/thumbnails/14.jpg)
14
Phosphoglycerol = Phosphoglyceride
Glycerol @ other alcohols
14
![Page 15: Lipid Revision](https://reader036.fdocuments.net/reader036/viewer/2022062422/56813019550346895d959486/html5/thumbnails/15.jpg)
15
CHCH(CH2)12CH3
CHOH CH NH2
CH2OH
H2C OH H2COH H2C OH
Sphingosine Glycerol
SPHINGOLIPID
1. What is the main structure for sphingolipid?Sphingosine
2. Draw the structure of sphingosine
3. Draw the structure of glycerol and compare between the two
15
![Page 16: Lipid Revision](https://reader036.fdocuments.net/reader036/viewer/2022062422/56813019550346895d959486/html5/thumbnails/16.jpg)
O ּוּו C - R
CHCH(CH2)12CH3
CH OH CH NH2
CH2 OH
SPHINGOLIPID
1. What are the functional groups in sphingosine?a. Hydroxyl (OH)b. Amino (NH2)
2. What do you get if you add fatty acid?Ceramide which is a sphingolipid
Fatty acid
CERAMIDE 16
![Page 17: Lipid Revision](https://reader036.fdocuments.net/reader036/viewer/2022062422/56813019550346895d959486/html5/thumbnails/17.jpg)
CHCH(CH2)12CH3
CHOH
CHNH2
CH2 OH
CHCH(CH2)12CH3
CHOH O llCHNHCR CH2 OH SPHINGOSINE CERAMIDE
17
![Page 18: Lipid Revision](https://reader036.fdocuments.net/reader036/viewer/2022062422/56813019550346895d959486/html5/thumbnails/18.jpg)
CHCH(CH2)12CH3
CHOH O llCHNHCR
CH2 OH
CHCH(CH2)12CH3
CHOH O llCHNHCR O llCH2 OPOCH2CH2N(CH3)3
Ι O
CERAMIDE SPHINGOMYELIN18
![Page 19: Lipid Revision](https://reader036.fdocuments.net/reader036/viewer/2022062422/56813019550346895d959486/html5/thumbnails/19.jpg)
1. Draw the basic ring structure of steroid nucleus2. What is it called?
Perhydrocyclopentanophenanthrene
19
![Page 20: Lipid Revision](https://reader036.fdocuments.net/reader036/viewer/2022062422/56813019550346895d959486/html5/thumbnails/20.jpg)
1. What is the difference between steroid and sterolA sterol has one or more OH groups
2. Give an example of sterolCholesterol
OH
CH3
CH3lCHCH2CH2CH2CHCH3 l CH3
SteroidSterol
Cholesterol(C27 H46O )
20
![Page 21: Lipid Revision](https://reader036.fdocuments.net/reader036/viewer/2022062422/56813019550346895d959486/html5/thumbnails/21.jpg)
21