Linear mentoring evolves into networks of scientistsJanet Rubin Margaret Gourlay Maria Escolar

Janet Rubin, MDResearch: Bone remodelingClinical: Metabolic bone disease and general endocrinologyUntil 2006 rose to Professor of Medicine, Division of Endocrinology, Metabolism and Lipids at Emory UniversityCareer Development path within the VA system ?VA system as mentor2006 + UNC, Professor Medicine

Mesenchymal stem cellNoggin, Nodal

BMP 2,4,7

Hedgehog

Wnt10b, 3a BMPsHedgehogLow

High

Wnt 10bSmad 1,4TAZSmad 1,4ShnPax3,7Sim1,Lbx1,Myf5Runx2, OsxPPARg. CEBPaMyogenin, MyoDOsteoblastAdipocyteMyocyte

Mentoring: Farming for the future

Mentoring: generalDirectedYour mentees work directly benefits your career

Off-topicYour contribution isAltruisticImproves your local environmentImproves your global environment

Mentoring: A case in pointDirect: Margaret Gourlay

Off-topic: Maria Escolar

Direct mentoring: MargaretJR: Expertise in clinical boneBasic biology insightsMG: Epidemiology training

Off target mentoring: MariaJR: Expertise in grant writingME: Turning great ideas into a viable RO1

Peer mentoring on an R01 applicationPreparationMy training and research

An unlikely combinationOsteoporosis screening and Krabbe Disease?

Peer mentoring in grant preparationReasons for successLessons learned

Training and other preparationBefore 2002BS microbiology/English, University of IowaDVM, Iowa State University; 4-1/2 years of veterinary practiceMD, Rush Medical CollegeFamily Medicine residency, UCSD; Medical Editing fellowship, Georgetown University2002-2004 Robert Wood Johnson Clinical Scholars Program, UNC2004-2007 UNC K30 Program2004-present, Assistant Professor, UNC Department of Family Medicine

Research on osteoporosis screening2005-07, UNC Program in Translational Science: Osteoporosis screening in younger postmenopausal women, Rubin is mentor.2007-12, NCRR K23 Career Development Award: Selective screening for osteoporosis in younger postmenopausal women, Rubin is co-mentor.Pending, NIAMS R03: FSH as a biomarker of bone strength in younger postmenopausal women, Rubin is key co-investigator.

Osteoporosis screening and Krabbe Disease?Some topic overlapClinical research Studies of diagnostic imaging testsDiagnostic accuracy analysis

Important differencesCommon vs. rare diseasePopulation health vs. approach to high-risk subgroups

Peer mentoring in grant preparationWhat a peer could contributeKnowledge of Marias past proposals (K30 and Translational Science Programs)Writing and editing experienceRecent experience with two NIH submissionsShared belief that Maria could finish grant on time

What didnt matterMedical specialty and research emphasisNo prior work on an R01

Peer mentoring in grant preparationReasons for successFascinating, clinically important topicOutstanding preliminary studies Highly motivated writing team

ChallengesCompressed time frameDifferent work styles

Lessons learnedYou can and should mentor at an early stage of your career.

Knowledge of cross-cutting disciplines (editing, epidemiology, biostatistics) can make you an expert at any stage.

For peer mentor, exhaustive knowledge of content area is less important than sound logic and enthusiasm.

UCBT

Mentor # 1Dr. Joanne Kurtzberg, Pediatric Bone Marrow Transplantation at Duke University Medical CenterContracts a small percentage of my clinical time

Encourages clinical research

Meets regularly with me

I observe her grow as a leader in her field

Mentor # 2Dr. Mel Levine, Director for the Center of Development and Learning at UNCProvides space and initial resources

Recognizes the importance of my work

Challenges me to become independent

The NFRDWhere is the funding?

Multidisciplinary team

Clinical service

No time for research

Krabbe Disease

August 2006 Newborn Screening for Krabbe Disease is implemented in New York State

Mentor # 3Dr. Joseph Piven, Director of the Neurodevelopmental Research Center (NDRC) at UNC

Common research interests

Has experience with NIH grants

Identifies key resources within UNC

Serves as a role model

Mentor # 4Dr. Eugene Orringer

Provides funding to protect research time

Identifies mentors at different levels

Supports all aspects of my work (clinical, research, academic)

Available when crisis strikes!

My first NIH grant R01

DTI as a tool to identify babies with Krabbe Disease in need of urgent treatment

In a prospective study of 100 babies with low GALC enzyme, determine if DTI can identify which newborns will develop infantile Krabbe Disease

Mentor # 5Dr. Janet Rubin

Don't despair. IT"S ALL GOOD.

No one can take away SIGNIFICANCE, NOVELTY and IMPACT away from you.

You go girl.

Mentor # 6Dr. Margaret Gourlay

Today I had to see patients until late, and work on some issues we had with the budget. I still need to send drafts of letters, look at the abstract, environment and data dissemination. Grrrrrr MariaI can put in a few hours ofwork after 8:30 tonight. Overall, you are in great shape. I will be on call on Friday night and in clinic on Saturday. Although I might have to take a nap first, I can help you late Saturday PM. On Sunday, you can do the page counton the full file so we know how close it is to 25 pp. Then you can trim and refine. Margaret

R01 Funded!

Probability of event-free survival was calculated by Kaplan-Meier analysis.