Limsoon Wong Kent Ridge Digital Labs Singapore
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Transcript of Limsoon Wong Kent Ridge Digital Labs Singapore
Show & Tell
Limsoon WongKent Ridge Digital Labs
Singapore
Role of Bioinformaticsin the Genomic Era
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What are the Themes of Bioinformatics?What are the Themes of Bioinformatics?
Bioinformatics =
Data Mgmt + Knowledge Discovery
Data Mgmt =
Integration + Transformation + Cleansing
Knowledge Discovery =
Statistics + Algorithms + Databases
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What are the Benefits of Bioinformatics?What are the Benefits of Bioinformatics?
To the patient:
Better drug, better treatment To the pharma:
Save time, save cost, make more $ To the scientist:
Better science
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Transcription Start PredictionTranscription Start Prediction
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Transcription Start Prediction ResultsTranscription Start Prediction Results
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Medical Record AnalysisMedical Record Analysis
Looking for patterns that are valid novel useful understandable
age sex chol ecg heart sick49 M 266 Hyp 171 N64 M 211 Norm 144 N58 F 283 Hyp 162 N58 M 284 Hyp 160 Y58 M 224 Abn 173 Y
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Medical Record Analysis ResultsMedical Record Analysis Results
DeEPs, the “emerging pattern’’ method
Beats C4.5, CBA, LB, NB, TAN in 21 out of 32 UCI benchmarks
Works for gene expressions ALL vs AML:
DeEPS (1 gene) - 0/38 & 3/34 Slonim (50 genes) - 2/38 & 5/34
Colon: DeEPS (35 genes) - 4/62 Alon (1000 genes) - 6/62
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Genome-Enabled FruitsGenome-Enabled Fruits
A lot of genes & proteins that are
candidate diagnosis indicators candidate prognosis indicators candidate drug targets
What’s Next?What’s Next?
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Evaluate & Choose the Better CandidatesEvaluate & Choose the Better Candidates
Easier to access
Uncomplicated to modulate
Clear path to $
Has experience
To do that, you will need to have ….To do that, you will need to have ….
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STRUCTURE
EXPRESSION
RELATED MOLECULES
MUTATIONS
DISEASES
PATENTS
INTERACTIONS
A Molecular Connections Database consisting of...A Molecular Connections Database consisting of...
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Thank YouThank You