Ministry for Economics, Labour and Transport of Niedersachsen

Life Sciences

in Niedersachsen

At the Heart of Europe

Biotechnology, Life Sciences

• Niedersachsen is one of the largest bioregions

in Germany: more than 5,000 scientists,

21 universities and colleges and 34

non-academic research institutions

• Strength in pharmaceutical biotechnology,

infection, neurobiology, stem cell biology,

medical engineering, veterinary medicine and

plant biotechnology

• about 160 Life Science companies and 50 medical technology companies

Biotechnology, Life Sciences

BIOTECHNICA Fair 2017

• 16th – 18th of May 2017 (biennial) BIOTECHNICA and LABVOLUTION

• more than 10,000 visitors in 2015

• Life Sciences, Biotechnology and Lab technologies (Smart lab)

• Marketplaces for BioServices, Innovation in Food, Industrial Biotechnology and

Personalized Medicine

• 11th BIOTECHNICA Award

Relevant Networks

• BioRegioN, Network for Healthcare and Life Sciences

Contact: Dr. Maike Rochon

• eHealth Niedersachsen

Contact Dr. Maik Plischke

• Nieke, Agri Food State Initiative

Contact: Dipl.-Ing. agr. Doris Schröder

• 3N Competence Center for Renewable Raw Materials

Contact: Dr. Marie-Luise Rottmann-Meyer

• COALA Competence Center of Applied Agricultural Engineering

Contact: Prof. Ruckelshausen

Clusters of excellence (I)

• Rebirth (Form Regenerative Biology to Reconstructive Therapy)

- focus on blood, liver, heart and lung

- focus on stem cell biology and reprogramming

• Hearing4all

Research: Improving Diagnostics

Better Hearing Devices

Assistive Technology

Promotion of Young Researchers

Translational Research Center (HörtechgGmbH)

Clusters of excellence (II)

• Nanoscale Microscopy and Molecular Physiology of the Brain and

DFG Research Center Molecular Physiology of the Brain (CMPB)

Advanced Microscopy

A1 Microscopy at the Nanometer Range / Cluster of Excellence

A2 Quantitative Molecular Microscopy

Neurodevelopmental Disorders

B1 From Neurogenesis to Synaptogenesis

B2 From Synaptopathies to System Dysfunction

Neurodegenerative Diseases

C1 From Network Dysfuntion to Psychiatric Diseases

C2 Aggregation Disorders - Parkinson's Disease

Technology Platforms

D1 Proteomics

D2 Viral Vectors

D3 Primate Models

D4 Electron Microscopy

Infection

• Hannover Medical School

- transplantation (immunology), gene & cell therapy, hepatology

- more than 3000 students, 80 Mio in funds (2008)

• Helmholtz Centre for Infection Research, Braunschweig

- investigation of medically relevant pathogens (Pseudomonas,

Listeria)

- 700 staff from 40 countries, 45 Mio budget from federal

government

• TWINCORE, Hannover Braunschweig Cooperation

- Centre for Experimental and Clinical Infection Research

- screening of biological compound libraries

- in vivo propagation of hepatitis C virus

- preclinical testing for humanized mouse models

Picture: HZI Staphylococcusaureus

Infection

• Fraunhofer Institute for Toxicology and Experimental Medicine

- focus on respiratory tract as target organ

- preclinical testing toxicology and pharmacology

- clinical studies phase I – IV for the registration of pharmaceuticals

(allergy, COPD, asthma)

• German Collection of Microorganisms and Cell Cultures

- the most comprehensive Biological Resource Centre in Europe

- more than 18000 microorganism, 1200 plant viruses,

600 human and animal cell lines, 770 plant cell cultures

- independent non-profit organisation

• Headquarter of the newly founded German Center for Infection Research (DZIF)

HZI, Streptococci on

mouse collagen

Infection

27 partners will form a tight research network to bundle Germany’s health research with the German Centre for Infection Research. Coordination and administration will be located at the Helmholtz Centre for InfectionResearch (HZI).

Neurobiology

• European Neuroscience Institute

- functioning and diseases of nervous system

- foster treatment of Schizophrenia, Parkinson, Alzheimer

• Bernstein Centre for Computational Neuroscience

- analyse function of the brain

- combine experiments with mathematical models and computer models

• German Primate Centre

- biological and biomedical research on and with primates

- host 1500 primates, S2 and S3 safety labs

- Primate biology, neuroscience (Parkinson, Multiple sclerosis) and infection (HIV)

• International Neuroscience Institute

- high end clinical treatment of neurological diseases

Stem cell and medical engineering

• Leibniz University

- research funds 2010: 80 Mio

- more than 22.000 students 2011/2012

- enabling technologies: biophotonic,

- nanoengineering, cell manipulation, tissue engin.

• Rebirth (Form Regenerative Biology to Reconstructive Therapy)

- focus on blood, liver, heart and lung

- focus on stem cell biology and reprogramming

• Hearing technology: Universities in Oldenburg and Hannover (Research Center Vianna)

• Otto Bock Healthcare GmbH, world market leader in orthopaedics

• NIFE (translation center of implant research, Tiho, LZH, Leibniz University H)

Veterinary medicine

• University of Veterinary Medicine

- founded 1778

- 6 clinics, 18 institutes, 5 centres

- about 2000 students enrolled

- areas of research: infections, clinical research,

neurosciences, animal health and food quality

- future: 18 Mio € funding zoonoses center

- host-pathogen interaction: Campylobacter,

Salmonella

• Federal Research Centre of Animal Health (Institute of Animal Nutrition, Institute of

Animal Welfare and Animal Husbandry, Institute of Farm Animal Genetics)

• European vaccine development research center

of Boehringer Ingelheim vetmedica GmbH

Veterinary medicine

• Lohmann Animal Health

- leading manufacturer and supplier of poultry biologicals

- offer modified live and inactivated vaccines

- address infectious bronchitis, Newcastle disease, REO and infectious bursal disease

- offer Feed Additives: Acid Blends, Amino Acids, Enzymes, Probiotics and Trace Elements

- GMP

• IVD GmbH

- IVD performs serological and molecular biology-based diagnostics of infectious

diseases in pigs, ruminants, horses, dogs, cats and exotic animals (reptiles and

amphibians).

• Fassisi GmbH

- develop on-sites diagnostics and for laboratory applications in small and large animal

practice or clinic.

Veterinary medicine

• WDT Industrial and Provident Society of German Veterinary Surgeons

- commercial cooperative of veterinarians since 140 years

- shareholders 6300 veterinarians

- sera, bacterial and fungal vaccines, specific diagnostic products e.g. tuberculins

- the only GMP certified facility for the production of tetanus serum in Europe

• Intervet

- 120 employees

- animal vaccines for EU

- products for cattle, horses, swine, sheep, dogs and cats

- 5 production units

Translation Alliance in Niedersachsen - TRAIN

Helmholtz-Centre for

Infection Research (HZI)

University of Veterinary

Medicine, Hannover (TiHO)

Zoonoses, Animal Models,

Veterinary Medicine

Infection mechanism, Pharmaceutical Sciences, Vaccines, Natural

Products

Synthesis of new chemical entities and

natural products

Chemistry-Mathematics-Biology Biology-Medical Research From Bench to Bedside

Translational

Centre

Twincore

Drug

Discovery

Centre

BRICS

Systems

Biology

Zoonosis-

Centre

Clinical Trials Centre

CTC

TRANSLATION

Medical School

Hannover (MHH)

Technical University

Braunschweig (TU BS)Frauenhofer-Institute for Toxikology

and Experimental Medicine (ITEM)

Systems Biology,

Bioinformatics, MicrobiologyInfectious Diseases, Regenerative

Medicine, Tumor Bank, Immunology

Drug Research, Toxicology, Pharmacology,

GMP-Production

Leibniz University

Hannover (LUH)

Plant Biotechnology

• Federal Research Centre for Cultivated Plants

- focus on Protecting Plants, Plant health, Plant

Protection Research, Reduction of Plant

Protection Products (Julius Kühn Institute)

• Federal Research Institutes for Rural Areas,

Forestry and Fisheries (von Thünen Institute)

- Economics of agriculture, forestry, lumber, food

and fish production

- material use of renewable resources, climate

- Biodiversity and organic farming

• Seed Production companies (sugarbeets, corn, crop, rapeseed) for example KWS SAAT AG

(# 4 in the world) (picture: KWS, in vitro sugar beets in culture)

Bioeconomy in Niedersachsen

• Weser Ems region

- Hot spot of Agrar economy in Niedersachsen (279 companies, 43%)

- Knowledge transfer: Networks for Bioeconomy like Nieke (network for agrarindustry)

and 3N (Renewable raw materials), Competence Center COALA (Competence

Center of Applied Agricultural Engineering), and DIL, German Institute for Food

Technology

- Projects: Enhance use of raw materials as chemical feed stock, managment and

quality assurance of dung/farmyard manure, Nutrition of the Future (Nutraceuticals,

functional food)

• DIL, German Institute for Food Technology

Contact Dr. Heinz

Bioenergy in Niedersachsen

• 1546 biogas plants are located in Niedersachsen

(end of 2014)

• Direct jobs: 1944

• Indirect jobs 4000 (plant construction, service and

maintenance, cultivation of energy crops, research and

education, lawyers, tax advicer)

• Installed electric power 885 MW (end of 2014)

• Plants produce about 25% of the renewable electricity in Niedersachsen

Start-up Centres

Jade Innovations-Zentrum, Wilhelmshaven

Medical Park Hannover GmbH, Hannover

SciencePark, Göttingen

• Lab and office space ready for immediate use

• Conference and meeting rooms available

• Access to Life Science networks, universities, institutes (MPIs)

Ministry of Economics, Labour and Transport of Niedersachsen

Friedrichswall 1

D-30159 Hannover

Phone: 0049 511 120 5585

www.nds.de

In Russia

Anna Urumyan

1. Kasatschiy per. 7

119017 Moskau, RF

Tel.: +7 495 730 40 43

Fax: +7 495 730 40 44

anna.urumyan@niedersachsen.ru

anne.hopert@mw.niedersachsen.de

Bioinformatics SME in Niedersachsen

• Original world‘s biggest biological

databases: TRANSFAC®,

TRANSPATH (30 years of development)

• Unique aproach for automatic discovery of

drug targets and biomarkers

• 1 mln. lines of code of geneXplain software

platform covering all bioinformatics fields.

• >1200 world-wide users including Big

Pharmas, red and green biotech and

academia.

• 12 employees in Germany and India and

cooperation with Russian software

development company (50 employees).

Drug discovery – like the old Gold Rush

Tools

But - old approach in drug discovery fails

Trovafloxacin - antibiotic

6 death out of 3 millions

Withdrawn from market due to risk of idiosyncratic hepatotoxicity in 2001.

Drug discovery should become a technology

Disease

Patient

Therapy

Bucket dredging

Novel approach – systems medicine!

Systems approaches will transform the way drugs are developed … to target multiple components of networks

and pathways perturbed in diseases.

They will enable medicine to become predictive,personalized, preventive and participatory

Systems medicine: the future ofmedical genomics and healthcare

Charles Auffray1*, Zhu Chen2

and Leroy Hood3

Genome Med 2009, 1:2

geneXplain platform – a tool for drug discovery

using systems medicine approach

geneXplain technology

Genome,TranscriptomeProteome,Metabolome

DNA methylation

Patient,Disease

Drug

NetworksTargets

Success story – new anticancer lead compound

Apoptosis

?RITA – p53 activation compoundFind a new compoundcomplementaryto RITA.

Cancer

geneXplain identified targets (key nodes) in the

network of cancer cell survival mechanism

PI3-kinase subunit

We found a new compound - inhibitor of the

drug targets

… …

ChemNavigator Library

24 million compounds

PASS programfrom Russianpartners

This novel anti-cancer compound was

validated in-vitro and in mouse xenografts.

Vehicle

Compound N23 10mg/kg

Compound N23 50mg/kg

We found TGF-beta1 as a potential off-target

effect of TVX. Promoter of TGFb gene contains SNPs

Trovafloxacin (TVX)

TGF-beta1

SMADsite

A G

STATsite

C T

The carrier of these two mutations is vulnerable !!!

Don’t give TVXto this patient !!

Market volume and trends

Trends: Constant growth• of outsourcing of R&D services in

Pharma companies• of Bioinformatics services in

world-wide drug discovery oursourcing

Volume of bioinformatics service market

Total volume of drug discovery oursourcing: - Search for novel targets. - Sequencing and analysis of “omics” data- Identification of drug mechanisms of action.

Сегмент биологических услуг занимает 26%

0 1 2 3 4 5 6

Russia

India

China

Japan

Italy

Spain

France

Germany

UK

Canada

USA

Market geographical segments

(bln. USD)

2010 г. $3,1 bln.

2011 г. $3,8 bln.

2012 г. $4,9 bln.

2013 г. $6,1 bln.

2014 г. 7,5 bln.

2015 г. $9,5 bln.

2011 year - $9,34 bln2021 year - $31,14 bln

Refernces: 1) Visiongain: Drug discovery outsourcing world market 2011-2021; 2) RNCOS: Bioinformatics market outlook to 2015

EU and German grants