Lichenoid drug eruption due to initiation of IFN alfa therapy for hepatitis C virus infection -case...
-
Upload
erick-lawrence -
Category
Documents
-
view
220 -
download
3
Transcript of Lichenoid drug eruption due to initiation of IFN alfa therapy for hepatitis C virus infection -case...
![Page 1: Lichenoid drug eruption due to initiation of IFN alfa therapy for hepatitis C virus infection -case report- Andreea Stancu*, Aurel Doru Chirita**, Irina.](https://reader035.fdocuments.net/reader035/viewer/2022062717/56649e585503460f94b50969/html5/thumbnails/1.jpg)
Lichenoid drug eruption due to initiation of IFN alfa therapy for
hepatitis C virus infection
-case report-Andreea Stancu* , Aurel Doru Chirita**, Irina Margaritescu**
* „Carol Davila” University Emergency Central Military Hospital, Bucharest ** "Domina-Sana" Medical Center Bucharest.
![Page 2: Lichenoid drug eruption due to initiation of IFN alfa therapy for hepatitis C virus infection -case report- Andreea Stancu*, Aurel Doru Chirita**, Irina.](https://reader035.fdocuments.net/reader035/viewer/2022062717/56649e585503460f94b50969/html5/thumbnails/2.jpg)
Introduction• Interferon alpha is the treatment of choice for
chronic hepatitis C virus (HCV) infection• Cutaneous reactions to interferon therapy,
both local and distant from the injection site, are not uncommon
• Eczematous and lichenoid reactions are most commonly reported
• Cutaneous adverse reactions were more common in the combined IFN/ribavirin than in the IFN monotherapy in literature
![Page 3: Lichenoid drug eruption due to initiation of IFN alfa therapy for hepatitis C virus infection -case report- Andreea Stancu*, Aurel Doru Chirita**, Irina.](https://reader035.fdocuments.net/reader035/viewer/2022062717/56649e585503460f94b50969/html5/thumbnails/3.jpg)
Clinical caseWe report the case of a 62-year-old man undergoing treatment with interferon alpha therapy for hepatitis C, who developed a lichenoid drug eruption associated with interferon injections
![Page 4: Lichenoid drug eruption due to initiation of IFN alfa therapy for hepatitis C virus infection -case report- Andreea Stancu*, Aurel Doru Chirita**, Irina.](https://reader035.fdocuments.net/reader035/viewer/2022062717/56649e585503460f94b50969/html5/thumbnails/4.jpg)
Clinical case
Initial lesions located at the injection site
![Page 5: Lichenoid drug eruption due to initiation of IFN alfa therapy for hepatitis C virus infection -case report- Andreea Stancu*, Aurel Doru Chirita**, Irina.](https://reader035.fdocuments.net/reader035/viewer/2022062717/56649e585503460f94b50969/html5/thumbnails/5.jpg)
Clinical case
Typical well-circumscribed papules on the anterior aspects of forearm
![Page 6: Lichenoid drug eruption due to initiation of IFN alfa therapy for hepatitis C virus infection -case report- Andreea Stancu*, Aurel Doru Chirita**, Irina.](https://reader035.fdocuments.net/reader035/viewer/2022062717/56649e585503460f94b50969/html5/thumbnails/6.jpg)
A widespread subsequent eruption of pruritic papules on the trunk and abdomen
![Page 7: Lichenoid drug eruption due to initiation of IFN alfa therapy for hepatitis C virus infection -case report- Andreea Stancu*, Aurel Doru Chirita**, Irina.](https://reader035.fdocuments.net/reader035/viewer/2022062717/56649e585503460f94b50969/html5/thumbnails/7.jpg)
Superficial lichenoid dermatitis, perivascular and perianexial (infundibulofollicular)
![Page 8: Lichenoid drug eruption due to initiation of IFN alfa therapy for hepatitis C virus infection -case report- Andreea Stancu*, Aurel Doru Chirita**, Irina.](https://reader035.fdocuments.net/reader035/viewer/2022062717/56649e585503460f94b50969/html5/thumbnails/8.jpg)
basal vacuolar changes with obscuration of dermoepidermal jonction
necrotic keratinocytes scattered melanophages
occupied in the papillary dermis
![Page 9: Lichenoid drug eruption due to initiation of IFN alfa therapy for hepatitis C virus infection -case report- Andreea Stancu*, Aurel Doru Chirita**, Irina.](https://reader035.fdocuments.net/reader035/viewer/2022062717/56649e585503460f94b50969/html5/thumbnails/9.jpg)
Conclusions• Dermatologic side effects of IFN alpha have
included skin rash, injection site reaction, diaphoresis, partial alopecia, dry skin, pruritus, hematoma
• Interferon therapy has also been associated with the occurrence or worsening of a number of dermatologic disorders
• The skin reaction at the injection site is a strong argument that supports our diagnosis
• To our knowledge, this is one of a few reported cases of a lichenoid drug reaction triggered by interferon