Letts Nitrile Synthesis - andreanagroup.com Chemical Reactions.pdf · Krohnke-Pyridine Synthesis...

144
- Acyloin Condensation Aldol Condensation Arbuzov Reaction Arndt-Eistert Synthesis Baeyer-Vllliger Reaction Bamford-Stephens Reaction Barbler Reactions Barbier-Wieland Degradation Barton Reaction Barton-McCombie Reaction Barton Olefin Synthesis Baudisch Reaction Baylis-Hillman Reaction Bechamp Reduction Beckmann Rearrangement Beckmann Fragmentation Benzilic Acid Rearrangement Benzoin Condensation Bergman Reaction Bernthsen Acridine Synthesis Biginelh Reaction Birch Reduction Bishler-Mohlau lndole Synthesis Bishler-Napieralski Reaction Blaise Reaction Blanc Reaction Bodroux Reaction Borsche-Drechsel Cyclization Brackeen Imidazole Synthesis Brook Rearrangement Bucherer-Bergs Reaction Cannÿzzaro Reaction Carroll Rearrangement Castro-Stephens Couphng Chichlbabin Reaction Clalsen Condensation Claisen Rearrangement Clemmensen Reduction Combes Quinohne Synthesis Conrad-Limpach Reaction Cope Rearrangement Cope Elimination Reaction Cory-KJm Oxidation Craig Method Curtius Rearrangement DakJn Reaction Dakin West Reaction Darzens Condensation Dess-Martin Oxidation Dieckmann Reaction Diels-Alder Reaction Doebner Reaction Edman Degradation Einhorn -Brunner Reaction Emmert Reaction Ene Reaction Eschenmoser Fragmentation Favorskii Rearrangement Feist-Benary Synthesis Finkelstein Reaction Fischer Indole Synthesis Fischer Oxazole Synthesis Flood Reaction Fnedel-Orafts Acylation Friedel-Crafts Alkylat]on Friedlander Synthesis Fries Rearrangement Gabriel Synthesis Gattermann-Koch Reaction Goldberg Reaction Grob Fragmentation Hammick Reaction Harries Ozonide Reaction Heck Reaction HelI-Volha rd-Zelins ky Reaction Henry Reaction Hinsberg Thiophene Synthesis Hofmann Reaction Hofmann-Martius Rearrangement Homer-Emmons Hunsdiecker Reaction Jacobsen Epoxidation Jones Oxidation Knoevenagel Condensation Knott Pyrrole Synthesis Knorr Quinoline Synthesis Kolbe-Schmitt Reaction Krapcho Decarboalkoxylation Krohnke-Pyridine Synthesis Kucherov Reaction Leuckart Reaction Letts Nitrile Synthesis Lieben iodoform Reaction Lossen Rearrangement Madelung Synthesis Mannich Reaction Milas Hydroxylation Reaction Mitsunobu Reaction McMurry Reaction Meerweln.Ponndorf-Verley Reduction Peterson Reaction Pinner Reaction Pfitzner-Moffatt Oxidation Pictet-Gams Isoquinoline Synthesis Plctet-Spengler Isoquinohne Synthesis Piloty-Robinson Synthesis Pinacol Rearrangement Pomeranz-Fntsch Reaction Polonovski Reaction Quelet Reaction Reformatski Reaction Reissert Reaction Reissert Indole Synthesis Riehm Quinoline Synthesis Riley Oxidation Ritter Reaction Robinson Annulation Rosenmund Reduction Rowe Rearrangement Rubottom Oxidation Ruff-Fenton Degradation Sandmeyer Reaction Scholl Reaction Schmidt Rearrangement Schotten-Baumann Reaction Sharpless Dihydroxylation Sharpless Epoxidatlon Simmons-Smith Reaction Simonis Chromone Cyclization Skraup Reaction Sommelet-Hauser Rearrangement Stephen Aldehyde Synthesis Stevens Rearrangement Swern Oxidation Tiemann Rearrangement UIImann Reaction Wacker Oxidation Wharton Reaction WhLting Reaction Wachterle Reaction Wolff Rearrangement Wolff Kishner Reduction Wittig Reaction 1,2-Wittÿg Rearrangement 2,3- Wittig Rearrangement

Transcript of Letts Nitrile Synthesis - andreanagroup.com Chemical Reactions.pdf · Krohnke-Pyridine Synthesis...

- Acyloin CondensationAldol CondensationArbuzov ReactionArndt-Eistert SynthesisBaeyer-Vllliger ReactionBamford-Stephens ReactionBarbler ReactionsBarbier-Wieland DegradationBarton ReactionBarton-McCombie ReactionBarton Olefin SynthesisBaudisch ReactionBaylis-Hillman ReactionBechamp ReductionBeckmann RearrangementBeckmann FragmentationBenzilic Acid RearrangementBenzoin CondensationBergman ReactionBernthsen Acridine SynthesisBiginelh ReactionBirch ReductionBishler-Mohlau lndole SynthesisBishler-Napieralski ReactionBlaise ReactionBlanc ReactionBodroux ReactionBorsche-Drechsel CyclizationBrackeen Imidazole SynthesisBrook RearrangementBucherer-Bergs ReactionCannÿzzaro ReactionCarroll RearrangementCastro-Stephens CouphngChichlbabin ReactionClalsen CondensationClaisen RearrangementClemmensen ReductionCombes Quinohne SynthesisConrad-Limpach ReactionCope RearrangementCope Elimination ReactionCory-KJm OxidationCraig MethodCurtius RearrangementDakJn ReactionDakin West ReactionDarzens CondensationDess-Martin OxidationDieckmann Reaction

Diels-Alder ReactionDoebner ReactionEdman DegradationEinhorn -Brunner ReactionEmmert ReactionEne ReactionEschenmoser FragmentationFavorskii RearrangementFeist-Benary SynthesisFinkelstein ReactionFischer Indole SynthesisFischer Oxazole SynthesisFlood ReactionFnedel-Orafts AcylationFriedel-Crafts Alkylat]onFriedlander SynthesisFries RearrangementGabriel SynthesisGattermann-Koch ReactionGoldberg ReactionGrob FragmentationHammick ReactionHarries Ozonide ReactionHeck ReactionHelI-Volha rd-Zelins ky ReactionHenry ReactionHinsberg Thiophene SynthesisHofmann ReactionHofmann-Martius RearrangementHomer-EmmonsHunsdiecker ReactionJacobsen EpoxidationJones OxidationKnoevenagel CondensationKnott Pyrrole SynthesisKnorr Quinoline SynthesisKolbe-Schmitt ReactionKrapcho DecarboalkoxylationKrohnke-Pyridine SynthesisKucherov ReactionLeuckart ReactionLetts Nitrile SynthesisLieben iodoform ReactionLossen RearrangementMadelung SynthesisMannich ReactionMilas Hydroxylation ReactionMitsunobu ReactionMcMurry ReactionMeerweln.Ponndorf-Verley Reduction

Peterson ReactionPinner ReactionPfitzner-Moffatt OxidationPictet-Gams Isoquinoline SynthesisPlctet-Spengler IsoquinohneSynthesisPiloty-Robinson SynthesisPinacol RearrangementPomeranz-Fntsch ReactionPolonovski ReactionQuelet ReactionReformatski ReactionReissert ReactionReissert Indole SynthesisRiehm Quinoline SynthesisRiley OxidationRitter ReactionRobinson AnnulationRosenmund ReductionRowe RearrangementRubottom OxidationRuff-Fenton DegradationSandmeyer ReactionScholl ReactionSchmidt RearrangementSchotten-Baumann ReactionSharpless DihydroxylationSharpless EpoxidatlonSimmons-Smith ReactionSimonis Chromone CyclizationSkraup ReactionSommelet-Hauser RearrangementStephen Aldehyde SynthesisStevens RearrangementSwern OxidationTiemann RearrangementUIImann ReactionWacker OxidationWharton ReactionWhLting ReactionWachterle ReactionWolff RearrangementWolff Kishner ReductionWittig Reaction1,2-Wittÿg Rearrangement2,3- Wittig Rearrangement

Named Reachon http//www customsynthesls com/acyloln html

A, qyl oÿ r-t Condensaf.i on

0

Na

"ÿ'0 " 'FI" OEt Pht_-," HÿII0

lÿ:eference Corap Org Syn, 3, 620 (1991)

Done

Named Reaction http Ilwww customsynthesls com/aldol html

Aldoi Condensat, or,

C) O-D

R' U,. R' L-ÿ .-" R3

, FI2 2) H;rJ¢. -

OH 0

Rg--ÿ"'-,.,(JL'R ÿ

R5 S "FI1R"

RofereIÿ.ÿe Colap Orÿ, "ÿ ÿ, 9,_ oÿl 1. ÿ (1991)

Done

loll

Named Reaction http//www customsyntlaesis corrdai buzov html

,ArbilÿOV Reacÿl o[7 iI

RQRO@P + R --,',IRO"

0R 0---.ÿ,

RO ...... R

Reference Chem Rev, 81, 415 (1981)

Done

1 of I ?/7/ON If) NO AM

Named Reactmnhttp//www customsynlhesls com/amdtmstmt html

Amdt-Elÿerÿ ÿ'?nthesls /.... {

RCOOH+SOCÿ RCOC1 + HC1 + SO2

RUOC1 + r-Hzl Iz Rr2C,C'HN: + CHg21 + Nz

Iq'.ÿ2OC'H! Iz + AF-'.2DFId2D ÿ F,2H22C,-,H

Refem1ÿe Angew Chem, 7ÿ,, 535 (1960)

Done

91"/AqIÿ 1ÿ3 Iÿ AM

Named Reaction http//www customsynthesls com/baeyez html

Baeye r-Vii hÿe r" Oÿldatt on

Rel:e:reÿico Coltlp, Ozrg 'ÿ, .. ,,.),ÿ, 7, 671-588 (199r,

Doile

l of I 2/7/00 10' 12 AM

Named Reachon http//www customsynthesls com/bamfol dstevens html

B amford-Sizevens Eea@l on

RN -, .ÿN--NH-Ts

H R

Na R, F;,I,,.-

HOCH2CH2OH FI/" \H

lÿ'eferezl,."e COlc'Lp Org ÿ)rn, 6, 775 (1991)

Done

1 of 1 2/7/00 10 12 AM

Named Reaction http//www customsynthesis conVbaibiei html

ar'bler F'.ea@l ons

I-I

FI--× R'J'[J"" R

R = I, IBr, (ÿ1 ['Ui = ,ÿ;['11 fll], Mg, LI, Zn

H,-ÿ FIN. /

FI ....... \ R

Rei'ereiÿce' Tetr-ahedin31ÿ, 48, 067 (1.992'

Done

l of 1 2/7/00 10,12 AM

Named Reaction http//www customsynthesis com/baÿbieiwieland html

E4arbier'-Wieland Deg radati on

HXRCHÿ2OOlvle + 2PhMg,X

RC H 42 AD H ) Ph =

R-CH= CHPhzL-trClq

--,-ti,-

RC H g C (OH)P it2 + 2, M gX + lvle OH

R-,FH=,2HPhz

Fc'OOH + Ph-,CO

Refe rsrLce TL, s685 (197ÿ)

<

Done

l of l 2/7/00 10 12 AM

Named Reaction http/iwww customsynthesm com/balton html

E: arl:on Reach on

h'v1,,,

.ÿNO

(\ OH

!_:yÿN-OH

\ ,OH

Pefvr.n,.ÿe Ktÿ,ew Ctÿ.ltÿ tnt Ed, 8, 525 (1964)

Dolle

1 of" 1 2/7/00 10,12 AM

Named Reaction http//www customsynthesls com/baltonmccomble html

Ba¢con-McComble Read, on

cl

[l tl- BU-:,=,t H

... -ÿR '(-i-ÿ-Fl

/ \

ReNrence Res Chem Intenaed, 1.9, 755 (1995)

Done

1 of I 2/7/00 10 13 AM

Named Reacnon http//www ctlstomsylathesls com/bmtonolefin html

[q at+on OI eft n SynÿchesTs tO N=N

"" t' "1

,ll 1) NH2NH2 - /ÿ'.,. .,\z--"

-'" " - 2) °,H2 S" '-

8) Pb(O/4.c)4

PEtÿ---j,,,.

h

\__/

Fÿ.ef'ereltce JAC8, Iÿ)6, 5018 (1984-)

Done

I of 1 2/7/00 10 13 AM

Named Reacuon http//www customÿynthesm com/baudlsch html

B aL,@Sch Rÿaÿl on

NH20H

HOOHOl.l2+

FLPfl.:rPn,"e TL, JbO.ÿ k14ÿ_6,ÿ

Done

1 of 1 2/7/00 10 13 AM

Named Reaction http Ilwww customsynthesis com/bayhs html

B a),,I Is-Hÿll m an P.e actl on

0EVVG---%, +

"% R)I.HDABCO

HO

EV'VG---ÿ\

Reference Tetrattedror4 44, 4653 (1988)

Done

1 of' l 2/7/00 l0 14 AM

Named Reaction http//www customsynthesis COln/becllamp html

Bechamp F' edÿ.ÿct, on

Fe

H©INHz

Refer.Itce Or:g React, ÿ., 428 ,'.1944-)

Dolle

2t7/00 10 15 AMI cA'I

Named Reacnon llttp//www customsynthesis com!beckmann hnlll

ect<m ann P, earrange m e.nt;

I--ÿ F, CI5 ,.--,

\ i=N-<>H I. i,iH

Refereiw.e Comp Org S)ql, I, 98 (1991)

Done

I nf I 217100 10 15 Arvl

Named Reaction http//www customsynthesls com/beckmannfi ag html

1

Feckmann Fragmen{-a#.lon,Ii

.............. J

Rx ./OH

R R

POIÿ.R-O[',I

Reference Org React, 11, 1 (1960)

Done

1 of I 2/7/00 10 15 AM

Named Reachon http//www customsynthems com!benmhcacld html

B e nztll c ,&cld F,'.ear'rang e m e v-ÿt

KOH

5'.ÿferÿ.llcÿ. Colap Org S..ÿ, 3, 621 (1991)

Done

1 of l 2/7/00 10 16 AM

Named Reaction http//www ctlstomsynthesls corn/benzoin html

E',ÿtlZ OI ÿ1 60}1ÿ IlSatl O11

CHO OHO

EWG

EWG,/

Xefereltco Orÿ,aaÿc Xeaeb,:ÿlÿ Iÿ( ;'69 (19€>,)

Done

1 ofl 2/7/00 10 16AM

Named Reaction http//www customsynthesls com/belgman htm[

Bergnlan Rea@ton

R.-_-2 - -.

Ref'e.w.nce Proc Naÿl Acad Acd, 90, 5881 (1993)

Done

1 of l 2/7/00 10 16 AM

Named Reachon http//www customsynthesm corn/bin nthsen html

13 ernthsen Acn dl r,e SyntF, esls

.........

H........ N --

I: ilÿ • .... i1

P, efereItce .l'OC, ZT, 2658 (1962)

FIÿ3OOH, Zh CI:,

A

Done

1 of I 2/7100 10 34 AM

Named Reaction http//www customsynthesB com/blgmelh html

B)glndll Rea,_ÿ) on

lÿferert,ze J&CS 9ÿ, 8741 (1973)

0

N H2

0.J[.

HN " NH

Done

1 of 1 2/7/00 10 34 AM

Named Reactmn

htÿp//www customsynthesÿs com/buch html

B Mrch Reduÿl,:,n !J

F1

ReferezL,:ÿ C,.ÿIap Org St, m, 8, 4,9.9 (1991)

Done

1 ofl2/7/00 10 35 AM

Named Reaction http//www ctistomsynthesls com/btshleimohlau html

Bist-iler-H;Skllaca. . Indole Sy'ntF, esis t

""n"" " N ÿ" :":- "<'"

H

PhNH2 . HBr

Reÿrezÿ,:e Hetoroc'f,?h,- (2olap,:,u.tt,ÿ 3, 22 (1952)

Done

1 ofl 2/7/00 10 35 AM

Named Reachonhttp//www customsynthesls com!blshlel naplelalsky htmt

!Bishlet-Napleralsta Rea@lon !

POCIs

R

Done

2/7/00 10 35 AM1 ofl

Named Reactton http//www customsynthesm corn/blame html

BlaJsÿ P,.eaÿJ on

OR,., ÿ 1)Zn

R/ÿt OEt 2) R-ONÿ-FU-"Sv" OEt

Rÿ" " '+ÿ:'N-ÿ_tl Bf

aq KOH

oR,+, _#

V"ÿ.. "OEt

R / ':%O

5"efereltse JOC 18, 1594 t, I.'+__,)

Done

1 ofl 2/7/00 10 35 AM

Named Reacnon http//www customsynthesls corn/blanc html

Blanc Rea,,ffl,: t-

+ ©H20 + HCIZnC'l2 Ot

Rete.mlw. Org lÿact, 1, 63 { 1942)

Done

1 of I 2/7/00 10 35 AM

Named Reaction http//www customsynthesls com/bodloux html

i1

l= oB 0 d[" 0 Lÿ'- C hi CI-J l b ab, ÿ', Al de hyde $y'Flt l'l eS l si

HC(OR)ÿ + RIM,_JX ---ÿ RICH(OFf)2 R-CHO

Reference JOC 6, 489 (1941)

Done

1 of I 2/7/00 10 35 AM

Named Reachon http//www customsynthesls com/blackeen html

Brackeen Imldÿole ,:j,,t ÿt[ ÿesbs

O O

IL.

O

H-OHO

H 0 ,'ÿ, CI' ,I H 4 t-ÿ .ÿ. c

i l-Ret>Nlv:ÿ 'I"L, 3ÿ, 1635 (19'.44)

Done

0

1 of I 217/00 10 36 AM

http//www customsynthesls com/blackeen html

Named Reaction

Brackeen ImLdÿole 5ynÿchesls

O O

O

R-CHO

H 0 ,ÿ, CN H4 0 ÿc

ReNÿ..ÿtce ÿ 3ÿ, 1635 (1994)

Done

Inf I

2/7/00 10 36 AM

Named Reaction http//www ctlstomsynthesJs com/blook html

B rook Rearrange m enÿ

sn.ÿ-.f..1.o." "I-I

it =:, 8

Eteiÿre.1ÿce J.,ÿ(3S IIÿ, 5609 (19901

baseH..f.__.). o-s,Rÿ

" ' n

iI

...... ÿ ............ J

Done

1 of I 2/7/00 10 36 AM

Named Reaction http//www customsynthesis com/bucheieibelgs html

B uchÿrÿr-B er,7ÿ F'_ea&i on

0 KCN(NH4)2COÿ

HCONH2

H 0

NH

Refere],ce J Ivied ctlÿm, ÿ3, 754 (1980)

Done

l of 1 2/7/00 10 36 AM

http//www customsynthesÿs com/canmzzm o htmL

Named Reaction

Caÿqtql zzaro P, earl ot-ÿ

CHO1) NaOH

2) H+

COOH CH20H

lq'efereItco JAUS 101, 3576 f[1979)

Done

2/7/00 10 36 AM

Named Reaction http//www customsynthesB com/calloll html

Carroll Rearr'angern ant

Rÿ< R 0.... j[

li -o. + Ro .....

0

C Hÿ:

bÿseR

./2L-R

I: ÿiOH"

Rete-reltce Org ,.q ,'Bt, 68, 2 10 (1990)

Done

1 of 1 2/7/00 10 36 AM

Named Reaction http//www customsynthesls com/castlostephens html

[ Caslro-Stephens C_oupllng I

Rj,-

RÿforelLce Org Feact, ÿ, 253 (1975)

Done

1 of 1 2/7/00 10,36 AM

Named Reaction http//www customsynthesls com/chlchlbabm html

,ThJd-ÿfbabiH P eaÿl,:,n

r',l a bl H 2

150 °C

Referert¢. JOC 46, 2134 (1981)

Done

1 of I 2/7/00 10 37 AM

Named Reacnon http//www customsynthesls com/clalsen html

Clalsen Condensation

O2 JL.

H3C" CEt

EtO"

O.jl.

,.- H2ÿ OEt

Oÿ" CH3

RPfezelÿ.cr, Col@ Oÿ S}¢t, ÿ, 79_5 0991)

Done

| ofl 2/7/00 10 37 AM

Named Reaction http//www customsynthesls com/claKsem lmnl

CI atsen Rearrange ment

BJ.

O "'" ":"

B-J°

I_1" -1

Refereilce 2'L,3ÿ, 4199 (1991)

Done

1 of [ 2/7/00 l0 37 AM

Named Reaction http//www customsynthesls com/clemmensen html

CI e m m ensen Reduch,:,n

O Zn(Hg)LR FI HCI RAR

Refereÿce Comp Org 8}eÿ, 8, 309 (1991)

Done

1 of 1 2/7/00 10 37 AlVl

Named Reactmn hrtp//www customsynlhesls com/combesqumohne html

Combes Qurnollne Syndqests

[ÿ--:"'- O.T..--'--.?0N H R R

H+

RJ.

":':- .......... bf:"" "F,

Reference JOC 37, B9ÿ2 f,197ÿ)

Done

t of 1 2/7/00 10 37 AM

Named Reaction http//www customsynthesls com/copeehm html

Cope Eli ill lt'-iÿfl 0t'1

\ /",., __ ,.,

-..ÿ>

Refereltce Orÿ React, II, 317 (1960)

Done

1 of 1 2/7/00 10 37 AM

Named Reactton http/Avww customsynthesls com/cowknn htm[

0/£=CH,..[

/- \

TE A

Done

Refereitce.T'''-'eÿ,ÿo Q4, 7586 (1972)

1 of 1 2/7/00 10 37 AM

Named Reaction http//www customsynthesJs conl/Cl aigmethod html

Craig t',,ÿ ethod

H×l_

tqablO.-,

E'eterelt,'o H.tero,:y.ÿli,: Cÿolt'tl.ÿoultcls 1 .... ÿ',1'.-?50)

Done

1 ofl 2/7/00 l0 37 AM

Named Reaction http/Avww customsynthesls com/cultlt.ls html

, +Curb Ltÿ Rÿarranÿ m ÿ n

C)A

R--N----ÿ©=CI

}P3H

/

]kR--N" ÿQR

H

R--NH2

Pÿl-e.llce Cnlÿ.p C)I"ÿ 9=, 8ylt, 6, 7..J (1991)

Done

1 ofl 2/7/00 10 38 AM

Named Reaction Nip//www customsynthesls com/dakin html

Dakl n Readcl on

C H 0J.

.)OH

H2Oz

NaOH

OH.t

0OH

R,ÿferen,?e Cÿ .1 Chem, @@, 102 (1977)

Done

1 of 1 217/00 10 38 AM

Named Reaction h/tp//www ctlstomsynthesls com/daklnwest Nml

Dab nA,%"estÿ Read:l O|'l

0

R....---lJ-- A,:" ,cj...... " '¢JH .,..

I baseNHÿ

CI

.-Ii-.... l" C Hÿ:

I

H N...ÿ..11 "" C H ÿ,

tl0

Reference Hebrocycllc Compoubÿ ÿ, 34-5 (1.957)

Done

1 of I 2/7/00 10 38 AM

Named Reaction

http//www customsynthems com/dmzens html

Eÿ'at'zens Corÿdensatÿon

o 0

× R COOEr

1) NaOH H R

2) ,', R

Rofe-re;ÿce Conlp Org Sylt, ÿ, 409 (1991)

Done

] ofl

Named Reachon http//www ctlstomsynthesls com/dessmattm htlnl

Dess-M arÿc, n 0×1 dah or,

Refere,tce Joc ÿ48, 41_,_ (1963)

Done

,-ÿ Ac

Aÿ:O, [ ,o OAC- - -\ I

ii n_[i:..ÿ... --.,,0,

OJ.

1 of 1 2/7/00 l0 38 AM

Named Reaction http//www custolnsynthesls corn/dieckmann htnal

LDÿeckmann Condensation i ' '

t

[ ..... 0 0 0 Et h ase .....COOEr--. . •

P,ÿfererÿce Comp Org S.ÿt, ÿ, 806 (199 i) COOEt 1

Done

1 of I 2/7/00 10 38 AM

Named Reaction http//www customsynthesls com/dielsaldel html

DJ els-AI der R eact, on

R

"ÿ [i".....

B:elh-?Nlle. (3ow.p Org S ylt, ÿ, 513 t 1991)

Done

1 of I 2/7/00 10 39 AM

Named Reactton http/iwww customsynthesls com/doebnel html

Doeb tqer Re acl:.l oH

NHa

0

,.ÿHo <c..l[ ;.°

;@ o.COOH

"Ph

P,v, fere.nce Aust J CheIa, 31, 863 (1978)

Done

1 oI l 2/7/00 10 39 AM

Named Reaction http//www customsynlhesÿs com/edmandegladatÿon html

Edm an De,gradatl on

0 I:l

J" .- N H

RefererLce .g.cta Chela 8caILd, €, 283 klÿJO)" '-=

I?h

t-l:--_ .,- . C,.... ÿ, >- ---- ,_,

II i

H' H

+..I._ N H :

H;, N " "11--"

- I

....

Done

1 ofl 2/7/00 l0 40 AM

Named Reaction http//www customsynthesis com/emhoin html

EiKjhnrl-i-BrctlTvÿer ' q-R.eÿt loKJ

O

/ÿ'--R CHÿCOOHPÿ-NH-NH2 + HN

. _ÿI:I

0

IL_ N.,N%[_ ÿR }-t----.N./N%: _.oR

<ÿ1 R'

B'.efereltce Sylttheÿ. l',,le'dÿods 9, No 44-9ÿ."9=ÿÿ.J_/

Done

1 of 1 2/7/00 10 40 AM

Named Reaction http//www customsynthesls com/emmelt html

E rn rn erÿ Rea@I on

.. ÿ-,..

L !1+N " R" "R

AI or Mcj

Mg CI2

[: .... 11 OH

L:"N"!'L'-'ÿ£- R

F:eferoÿce JC8 EC], 2 it4 (1969)

Done

lofl 2/7/00 l0 40 AM

Named Reaction http//www customsynthesls con-dene html

EKtÿ' Reaÿl Olq

H

;ÿ X Le ÿ,ts Acid HXelte elloplule

Rÿtereÿice Comp Org Sylt, S, i (1991)

Done

1 of 1 2/7/00 10 40 AM

Named Reaction http//www ctlstomsynthesls com/eschenmosel fi ag html

IEschen R1 oser Frag m entah on

O\

R

HsC'-iÿSOz-NH-NHz,R .l:l

lq,'eferel,,:e .lOt2 ÿ8, 1900 '1993:,

Done

1 of l 2/7/00 l0 40 AM

Named Reaction http//www custolnsynthesis COllÿfaVolsku html

Favorÿkll Rearrange m ent /OJL..c'l

[i. ;rNaOH

C rZl©H

ReNronco Org Feact, II, 2,61 (1960)

Done

I of 1 2/7/00 10 40 AM

Named Reaction http//www customsynthesis com/feist html

F eist-E: enaP,./ÿ!',,,,ÿ Jtlnÿuiÿ t0

HaO"ÿ':'ÿI + I'JL"oEt

O ":':"'" C H,ÿ

OH30ÿ)L'OEt

O" - O H3

lÿ:ÿference TOC2 4S, 1324 (19o[,,

Done

1 of I 2/7/00 10 40 AM

Named Reaction http//www customsynthesÿs com/finkelstem html

Fÿ nk#lstel n Reach on

R-Br + Nal "- R-I + blaBr

P,'eferel,ce TL ÿ, 2055 (198 I)

Done

l of I 2/7/00 10 40 AM

Named Reaction hrtp//www customsynthests com/fischel mdole html

Fischer IndoJe Sy'nthesis

R

NNH

Zl'l CI2

Refel-enc.e Accts, Chem Res, l,i, 275 (1981)

Done

+ NH3NH

1 of 1 2/7/00 10:40 AM

Named Reaction http//www customsynthesls com/fischeloxazole htlnl

Fischer Oxÿazc, le S).,,nÿhesJs

OH..U

19 ....... CN

+ R-CHCÿHC'I

PÿefereItce TL 4-391 (1971)

Done

l of' l 2/7/00 l0 41 AM

Named Reaction http//www customsynthesls conVflood html

Flood P,.eaÿ.l on

{-I

RaSi -- .... SIRsN m4 el

J,-

H28 0..,I.CI-- St FIs

cn-r Chem, 88, _',_', (t980)Reference Top -'ÿ "-

Done

! ofl 217100 10 41 AM

Named Reaction http//www ctisiomsynthesis com/fi ledelacylation html

Friedel-Cr'af'm A, cy'latior, R.ea@iotq 1

f-Il/

.... " FiC, t-u- I - ..... _-tl

I7 il ÿ LI i]-: ...... ,ÿlr- I.:: --:.:.:.. -

'B

R.feÿ'Lce. Comp OÿL. 8},U't, 2,753 (1991)

Done

2/7/00 10 41 AM1 ofl

Named Reaction http//www customsynthesB com/fi ledlaendel html

Fr'l edl ander ÿynÿbests

Base .R

"'H

Petereitce Org Feact, ÿ8, $7 (1982)

Done

1 ofl 2/7/00 10 41 AIVl

Named Reaction http//www cuslonlsynthesls com/fi les html

Frtes Rear'rance m enÿc

.:..ÿ ...... OH .ÿ.. .-" OH

--. f: il H.ÿ + R..H Iÿ:ÿ il

0 0

iÿ.el:e:renre Or:ÿ P, eact, I, 34ÿ ,,'194L)

Done

1 of 1 2/7/00 10 41 AM

Named Reaction http//www customsynthesls com/gabi lel htnll

Gabrl el ÿynthesls

0

N'K+ + R-X

0

NH2NHz

Done

mltce Comp Org 8y1ÿ,6,79 (1991)

R-NHz

1 of 1 2/7100 10 41 AM

Named Reaction http//www customsynthesis com/gattel mann html

Ga'cl-e r m ann-Koch Rea@i on I

iJ

. .,2 0CO I HCI ¢ÿ ÿ c_ H

AI _ I...:

/4,-Idi'mz, rÿ of ÿ'u2,;I2 ÿllc, m_ÿ rea,;1],z,n to pr,-,, ÿ:ed ÿt 1 ÿTt,,1

PefereItce J Orgmt,-_,nteiT£ Chem, 194, 22 1 (19E'O)

Done

1 ofl 2/7/001041AM

Named Reaction http !lwww ctlstomsynthesis com/goldbeig lltml

Gclldberg Reacq-I on

C)I/

" N ....it_.. p,

H

I2::i":":':J "N'- .... R

P, etererteo Org React, 14, 19 ¢'9°'ÿi'

Done

1 ofl 217/00 10 42 AM

Named Reaction http//www cuÿ,iomsynthesÿs corn/grab html

Gr'ob Fra, g m entatl on

(..B,.[ t-ÿase

OH

E,x-oauple

..... .. ÿ"ÿB r

-i.-2

O,.,..;

.° -ÿ-.

[ tl'i!ÿ + Bt

-,t 7Reiÿ.wnco ÿLiap Org Sÿi, #, 1044-(1991)

Done

I ofl 2/7/00 l0 42 AM

Named Reaction http//www customsynthesls com/hammlck html

Ham mid; ReactJ on

30H

FI-CHO

.: ÿ ---°] ..-

OH

R.ofereilcÿ JOC 36, 2002 (1971)

Done

I of I 2/7/00 10 42 AM

Named Reactzon http//www customsynthests com/hmlles html

Ham es Oz,-Jnl de P eactt on

R R R O"R

R)==o

R

FI+ o==ÿ,

R

lq'efereIL,:ÿ bÿccb ,-ÿhÿm .... lq'.eÿ 1, 31=,,, iÿ6o,,-'-ÿ

Done

1 ot 1 2/7/00 10,42 AM

Named Reaction http//www customsynthesB com/heck Imnl

Heck Reachon

R 1"/>ÿ22 Yf (0 &l-),3+ i"'t] PPhÿ, ÿV

DMF or TEA

Pÿ.feÿztCÿ Oÿ React :ÿ', 345 (1982)

Done

1 of 1 2/7/00 10 42 AM

Named Reaction http//www customsynthesls com/hellvolhazd html

Hel I-\fol hard-Zellt-ÿsk-, K e acd:.i on

RCH2COOH1)P, Br2

- RCHCOOHI2) H20 BI

lÿ'eteÿt,> .1/ÿC8 91, 7098 ,: 1969)

Done

I of 1 2/7/00 l0 42 AM

Named Reaction http//www customsynthesls com/heniy html

Henr3,, R eac't-ÿ on

R. N C)2--.,..-

13//

FII .-JL R2jl-

Base

B'.efereItce r3olal) Orÿ, ,3ÿrtÿ 2,, 321 (19911

Done

I of 1 2/7/00 10 42 AM

Named Reaction http//www customsynthesis com!hulsbetgthiophene htnll

Hi nsberg Tlni optlene .ÿyn±t-,esis

+ ROOC,..8.. C'OOR

FI 19

t-I O O C;--'% 8.-"ÿ--- C 00 R

RefeNnce JNÿIÿ 87, 1759 ÿ1.ÿ6_,)

Done

I of I 2/7/00 10 43 AM

Named Reaction http//www customsynthesB com/hofmann html

H o fm a t-tÿ-ÿ R f. a,..ÿl o n

0[ NaO H

FI"--L" N H2 Bi.2 R-N=C=OH20

R-NH2

5:eÿmn.,:'e CoJ::p O:"g$)ÿt, 6, 800 ( 1'.-?91)

Done

1 of I 2/7/00 10 43 AM

Named Reaction http//www customsynthems com/hofmannmaltms html

H o friq sttq n- 1',4 a H;I L.IS E ÿ a r'r a n,_ÿ e i-tl ÿ r-it:.

NH2.J.,. (ÿ- El

kJN H

.scLÿ ÿ

CHÿ

jr. C 3S, 1642 (1970)Re fereÿtL"e -) "

Done

1 nf I 2/7/00 10 48 AM

Named Reaction Nip//www customsynthesls com/hoi neiemmons html

Horner-E m m ons-Wads'ÿ,'orÿh R eaÿJ on

,D

+

Lq CÿII, //

r,,¢Ip_ (-)---_ IF --. __..._-ÿL_.._ÿ_) F.Ie IÿI

rvle o

.[

"-"OMÿ-" e

Referelÿe Comp Org Syn, 1,'/'55 (1991)

Done

1 of 1 2/7/00 l0 49 AM

Named Reaction http//www customsynthesls com/hunsdtecker html

Hunsdl ecker Reacÿl on

R-COOAgX2

R-X +CO2 +Ag×

E'er.rely'.. JOC 44, 3405 (1979)

Done

1 of 1 2/7/00 10'49 AM

Named Reaction http//www customsynthesis com/jacobsenepoxidation html

B'.etereiÿcP Colttp Or:ÿ,_ ÿrll #,821 (1991)

Done

1 of 1 2/7/00 10 49 AM

Named Reaction http//www customsynthests coin/jones html

Jones C:,ÿt dart c,n

O.... CrOdH+ R.../L OHR OH ÿ-

a,ÿtone

OH1

IV "FIt- t Oÿ ÿH +

,i,-a,:ÿ_tone

0R'/l 'R

Fÿterel'tct- COlttp Org o, ÿ5ÿ,_, ,rzt, ÿ,,-__, (1991)

Done

1 of 1 2/7/00 l0 49 AM

Named Reaction http//www customsynthesls com/knoevenagel html

V£noevenagef G_ÿndensatf or7

0 0J[ .IL R

RO " -J "2

l..

Base

FIC)O(-: ,C.C)C)FI

FIÿ 'H

fere]lce Comp, Oeg 8yÿ, 2, 341 0991)

Done

I of I 2/7/00 10 49 AM

Named Reaction http//www customsynthesls com/knollpyHole htnal

knott" Pyr'role 5),ÿltÿe sJ

o

" .... zEt

o

H

Fefÿrelÿee TCsZ 36, B53 (1971)

Done

1 of 1 2/7/00 10 49 AM

Named Reaction http//www custonlsynthesls com/knoltqumohne html

Knon" Qÿ.ÿ nolJne S, yntheÿls

H

-..2+ - 0----%°

E'...feÿlÿce JC,C 34. 17n9 ,; 19691

Done

1 ofl 2/7/00 10 50 AM

Named Reaction http/Avww customsynthesls cotÿJkolbeschmÿtl html

Kol b e-,.qch m it1: F:each onI

Reiel-eiice JCS 3145 (1954)

O" Na+

I I 1 ) C 022) H+

OH

Done

1 of I 2/7/00 10 50 AM

Named Reaction http//www custonlsynthesls com/ktapcho html

kr ape_h,., Decar'boal ko×,/I att on

LI ol !<CN

DMF or DM80

Rÿtere:nce Slmthesls ;SOS (1982)

Done

1 of I 2/7/00 10 50 AM

Named Reaction http//www customsynthesls com/kJohnke html

Krÿ;hnke PyrJ dJ ne Synthesis

0

0I+-,"

Bi'"

lÿ:elÿ.rÿiÿco JOg, .ÿI, 850 ÿ°1986)

Done

1 of I 2/7/00 10 50 AM

Named Reaction http Iiwww customsynthesls eomlkuchelov html

Kucherov R eaÿJ on i ÿ* I%/, I ,,

R RHq S 04

TH F,'H-:'-'

Rel:el'ertc. JAC8 8K 3964 (1963)

Done

1 ofl 2/7/00 10 50 AM

Named Reaction http//www customsynthesls com/leuckalt html

Leuckarÿc F ÿaÿloÿ-,

NH4+ OCOH

A

53-ferÿitce .IOC 33, 1647 /19alL-q)

Done

l of | 2/7/00 10 51 AM

Named Reachon http//www customsynthesls com/letts html

L ei-bs Mitt'Lie S',!nttnesls

R-COOH gSCNR-ON + {-:02 + KH8

ReNmtw.e Ctÿm t%ÿv, 4ÿ, 264 (1948)

Done

1 ofl 2/7/00 10 51 AM

Named Reaction http/&vww customsynthests com/hebemodofol m html

Lteben Iodogorm g;eacÿloni

O 1) NaOIR"'IL C H:,, 2) NaOH

1,

0R..JL-OH + CHI?,

4l:i'.eNreice I Ch.m Ed, 36, 572 (i.959)

Done

2/7/00 10 51 AMloll

Named Reaction http//www customsynthesls com/lossen html

Lossen Rearr'an,gernet-ÿt

OTsCI

R N-OH BaseH

NHR1 Rz

IR-N=C=©

O

'R--ÿ,rJLN_R

Z H iR-NH-,

E'eÿiÿce Comp Org S)m 6,821 (1991).............. i

Done

1 ofl 2/7/00 10 51 AM

Named Reaction http Ilwww customsynthesls condmadelung lltml

t',.,1 adel,_.tng Syt-,thes.s

.,CHs

NaOEt

H

Reterolÿc. JOC 4e_,, 4515 (19ÿ'ÿ 1)

Done

1 ofl 2/7/00 10 51 AM

Named Reaction http//www customsynthesis com/nmnnich html

M anni c[-ÿ F(eaÿl on

0HN-.FI + HCHORÿ

0II

"FI

Refereiÿ.ce Comp Org S)rÿ1, ÿ, 893 (19.91)

Done

1 of l 2/7/00 10 51 AM

Named Reaction http//www customsynthesis comhmlashydloxylatlon html

tvlll as Hydro'.ryl art on

H202

metal o×lde

Ftete>Itce . ,-.,ÿ, 6B, t841 (190])

Done

1 of I 2/7/00 10 51 AM

Named Reaction http//www customsynthesis condnlitsunobu html

M I .+slÿn obl_t Eeaÿi _' o n

OH

R

NU=EtOOC--N==N--COOEt

PPhÿ, Nu" R'''" R

Refereltco Orÿ, React, 42,335 (1992)

Done

1 of l 2/7/00 10 52 AM

Named Reaction http//www customsynthesls com/mcmuuy html

Jt M ct',4 Ltr'ty Rea@lon

On'jl" n

R R'},ÿ/

R" \R

Reference Coiap Or.& Sÿt 3, 583 (1991)

Done

Iofl 2/7/00 10 52 AM

Named Reaction http//www customsynthesls com/meeÿ were html

IM e er,,'ÿ'et t>Pnn)-ÿd,)rÿ-\!er'l ev Redudc)o)n

0 0 H

BI,.II,FI2 + OH ../[--..C.H3

AI(O- pr): 0 H

I=I1 - Rz+

CH

0

lÿ:eferenre Comp Org S)rit 3, 88 (1991)

Done

l of 1 2/7/00 l0 52 AM

Named Reaction http//www customsynthesm com/petelson htnal

Pet.erson Reaÿlon

0 R', SIR-"v-" #'

+M+

OH.... R'

"/ "r

8ÿRs

R'\\ /

Referelwe Colrtp Oÿ Syll I, 782 (1991)

Done

1 of 1 2/7/00 10 52 AM

Named Reachon http//www customsynthesls coln/pnmeÿ html

Pl 1"11-1ÿ'1" P--.ÿ ac"t1011

NHNSR4

Fil--Cÿ[,l

I+

',!'Fÿ

Refe reiLce J C2helu Res 134-(1978)

[RsOH

Done

NHR, __ÿ//

'NRÿF4

R+ --C(Cÿ

1 of I 2/7/00 10 52 AM

Named Reaction http//www customsynthesls colrdpfitznel moffatto×l html

F'11%zn er'-M offatt- Oxl dah c,n

[email protected],,'

DCC, H+

Refevelw.e Comp Orÿ Sÿ, 7, 291 (1991)

Done

1 ofl 2/7/00 10 52 AM

Named Reachon http !/www customsynthesls com/pictetgalnslsoqumohnesyn html

Pl ÿce'c-bamÿ, Isoqtu n,;,lÿ r-ÿe S),'tqt:t'ÿesl s

OH

P2 05

R

Iÿ:oferen,:o l:'erIml qW, alÿs 1 52,9 (1979)

Done

1 ofl 2/7/00 l0 53 AM

Named Reaction http f/www custolnsynthesis conVpictetspenglel Isoqumohne html

PJcfei>Spengler IsoquÿnolJne Syn!;hesÿs j{

I + ILI"" "HNHz R "

H+Fll]l

FIO

Done

lÿeferellce Heterocvclea., 39, .'-9- ÿ;U_ (1994)

1 of 1 2/7/00 10 53 AM

Named Reacnon http//www ctmtomsynthesm com/pllotylobmsonsyn html

F'f l,-ÿfv'-Robl nson Synf.hÿIÿ

--N# .iEt

s -, "OH..,

A

HCI

Hÿ Cÿ.__ÿ/C Ha

Et--- .H.,-" -- Et

5ÿ1"ÿ1t,;o JOC ÿ,9 ÿ_'TJ (1974-)

Done

1 ofl 2/7/00 10 53 AM

Named Reaction http//www customsynthesis com/pmacol html

PI nacol Rearrange ment:t

FI OHR--_ \ÿ ,/

no

H+ F1 .O

Eÿterence tZomp Org Sylt, 3, 721 119'-)1)

Done

1 ofl 2/7/00 10 53 AM

Named Reaction http//www ctlstomsynthesls com/pomel anzfi ltsch html

0JL .oEt

Refel-e1ÿe Hetorocycles SS, 601 (1987)

H+ ~a. .ÿ.

--" I !Lj:x--.r-:.:...ÿ--ÿ ..,,,.:.ÿ:'2-

'!I!

Done

1 of 1 2/7/00 10,53 AM

Named Reachon http//www custonasynthesls com/potonovsM html

polotlo¥'skl Re action

ott

IR-,

,_3

+ .U.Fÿ"-

Reÿmlÿ,:e Comp Org 8ÿl 6, 909 (1991}

Done

1 ofl 217/00 10 53 AM

Named Reaction http Ilwww custonlsynthesls com/quelet htlnl

QLxel ek P eadcÿ on

o rÿ,ne

Reference Com!gt Rend, ÿ02, 955 (1936)

Done

Zn C;I2

HCI

I ofl 2/7/00 10 53 AM

Named Reaction http//www custonlsynthesls comb efol matsky html

Relÿorm atsk,,/R.eaÿJ on

0 0+ ....... IL

.'£-. [ OEtBt

ZtlOH

R

0

OEt

E'.ererelto, (ÿLII['[? Or:-:_',, S)ÿL, ÿ, 277 (1991)

Done

1 ofl 2/7/00 10 53 AM

Named Reactionhttp//www customsynthesls comb elssett html

1) ÿ,cNJÿ

2) H+ 3H

E>fÿrelwe A,::Iva.u He'terocyc Chela, 24, 187 1979)

Done

1 ofl2/7/00 10'sq AM

http//www customsynthesÿs comheÿsseitmdolesyn htmlNamed Reaction

P,.e,sserq- IF, dole Syr,±t-,esls

1) (COOEt)z ÿNaOEt2) Zn/HOAC

NOz s) ,ÿ

B'ÿferettce HeÿmcyclS: Compourtÿ 3, 18 11962)

Done

2/7/00 10:54 AM

Named Reaction http//www customsynthesls colrdl lehmqumohnesyn html

RIeh m Qul nr_,llne ÿ,ynthesls

"'NH2 . HCI

R

(::+ OH4

Refereilce Heterocyclic Colapc, urtds 4, 16 (19.52)

Done

1 ofl 217100 10 54AM

Named Reaction http//www ctÿstomsynthesls com/llleyoxldahon htmt

R,I e},' Oxldat, c,n

0

ReNrelÿce Oÿ React, S, 331 (1949',

Done

I of 1 2/7/00 l0 54 AM

Named Reaction http//www customsynthesls cont!littei html

F'.rtrt:e r R ÿ ac"tri ,-in

R-ON I.H.H+

tl I-I

.R

Iÿrerence TL 3ÿ, 6967 ¢ 1994)

Done

1 ofl 2/7/00 10 54AM

Named Reaction http//www custolnsynthesls com/lobmsonannulatlon html

R obl nsolq ,,ÿlqlq i_ll a"l'l orl

t

Eÿferelÿce JNÿ 11:, 5'.4J4/1.. J)

base

Done

o O

r...ll ...... p, Jl

i._..] + .....

1 of ! 2/7/00 10 54 AM

Named Reaction http//www cu,,tom% nthesÿs comb osenmundÿeductÿon html

Rosenrn und Rÿduÿion _J

Cl 0...ll. F'd-BaSO4 '- [1.

R" C'I Hz R H

Refemzÿce JOC ÿ6, _5159 (1991)

Done

1 of 1 2/7/00 10 54 AM

Named Reaction http Nwww customsynthesis com/lowe html

P.,3Y,,'e F'.e arrall5e m e tTÿ

R,At

H+If--

0

Refe l'allce .IACS ÿ3, 22,98 (1951)

Done

1 ofl 2/7/00 10 54AM

Named Reaction http//www ctlstomsynthesls com/mbottomoxldatlon html

Rubotÿo m 0;.:1 datl on

.ÿ 0 H

I1. m-Opÿ ÿ..f --(-) ÿ, r," - olrl#

T"(-'" 9q'gF;'.eI:eÿiÿe .... ,-, ]Is, 3 146 (1.. _ )

Done

l of I 2/7/00 10 54 AM

http//www customsynthesis com/lufffentondegi adatlon html

Named Reaction

P.,_tC¢ F e nto n D e,3 radatt o t-,

OH

R ;OOH

H202

F@+

0

R+cQ

ReNreitce Cÿboh}ÿ-I Ros, 90, 123 (1981)

Done

2/7/00 10:55 AM

Named Reaction http//www customsynthesls conVsandmeyel html

3alq di"N e'ylÿF R eact;I Ot-i 1

CuX-..ÿ +

N2

X= Cl, Br, ONgÿ,ferolÿce F'ertmÿ Trr:ats, l 645 (1987)

Done

1 of 1 2/7/00 10 55 AM

Named Reaction http//www ctlstomsynthesls com/scholl html

3choll Re acl;ll3tl

Refereÿrtce JACS l,I],:a, :5252 (1980)

Done

1 ofl 2/7100 10 55 AM

Named Reaction http//www custonlsynthesis com/schmidtieauangement html

Sch ill J dt R e arrange m ent

oHNa

R/JL.× H+

X= H

X= R

\X= OH

'- R-CN +

"- RCONHR

RNH2

RNHCHO

'9l%l-ereltc* Comp Org S),it, #, 817 kl- 91)

Done

1 of 1 2/7/00 10 55 AM

Named Reaction http//www custon3synthesm com/schottenbaumann html

Sch OITÿ. e)-)- E; aU )ll a)-ÿ n Iz

0R-NH2

/ aq NaOH c, NaHCO.ÿ__//\\ R-OH

aq NaOH

Done

5"efe.'re1ÿce Bull Chem 8oc Japa1ÿ 42, 1756 ,1969;

0U

R ...... "O-R

I of I 2/7/00 10'55 AM

Named Reaction http//www customsynthesm com!shal plesshydl oxylatlon html

Sharpl ess D)b.vdrox3,'l at)c,n

R<

R--ÿ4,.,,H

R

AD-)-nm-ÿ,

, [)-)Ill }',-cÿa,-

R = largest, F', = medium, R = srnsdlest

HO OH

H,,,"ÿ-ÿ%H

R R

RP, efereace Chem Rev, 94, ÿ44.3 (1994)

Done

HO OH

D H

1 of 1 2/7100 10 55 AM

Named Reaction http//www ctlstomsynthesls corn/shin plessepoMdatlon html

8harpless Epÿ,.,tda Jon

Opt Acÿ¢e - 61ethvL ta'ÿ&te{n Fi' CH;,CI-,

.. 0IR" [ÿ-'ÿ- ÿC)H

E:e.-Ierelÿ.cÿ r-Jcmtl.ÿ Org S:,,m, 7, 589 (1991)• high en =u-d]o punla,' prech, tal-,le al-,-,:,lute _ÿtereo,:6ernlslr,/

Done

217/00 10 55 AlVl1 ÿ91

Named Reaction http//www customsynthesis com/sunnlonssnalth htlnl

Sire m or1 s-Smith Re aÿl otl

P, efere:tlce CoB. Cÿclÿ. Cheitt Comlttuiÿ. 4#, 2751 (1981)

I

Done

1 ofl 2/7/00 10 55 AM

Named Reaction http//www ctlstomsynthesls com/smaonis html

11110KIIS Chroi-ll oÿiÿ9 ?, '

OH 0

PCf,_'.ls

P, efPreitcp ÿ.lx_ÿ .T ÿ-2helt't Bÿ, 17,67 (1972)

Done

1 of l 2/7/00 10 56 AM

Named Reaction http//www customsynthesls com/skiaup html

sl,'.r'atp Re act.i on

.,OH H2ÿO4

;o.L../OH Pt't.NO2

Roforeiÿce Jr'2S, P,-'rInIt q"5,::at.s I, ÿ60, 26_:, ,',1972)

Done

1 of l 2/7/00 10 56 AM

Named Reachon http//www customsynthesls con#sommelet html

Snnl melet-HaLtse r Re arr aÿlÿ,e me rlt

+@ÿNÿz"

Fÿferÿrt,:. JCX-2, gq', 5034 (1992)

Done

I of I 2/7/00 10 56 AM

Named Reaction http//www customsynthesls conl/sommelet html

Sorn metet-Hauser Rÿ arratlge Rle Ht

MeI

+ N -- Me

.] ;" K:,,0NH:

-H',

RefererLcÿ JCC, -ÿ7, 5034 (1992)

Done

1 of I 2/7/00 10 56 AM

Named Reaction http//www customsynthesls corn/stephen html

:;-tephe n Aldeh,/de :;yhthesÿs 'J

ON GHO

Referelwe JO2, 37, 318 (1972)

Done

1 of I 217/00 10 56 AM

Named Reaction http//www customsynthesB corn/stevens html

Sic ÿ,ÿ ns Rearrangen]ent

Fll/

%

t11/

E Vÿ' G r'iÿ

r - FLÿR.,,

Re.fore]lee IALÿ,, 96, 1547 (1974)

Done

1 of 1 2/7/00 10 56 AM

Named Reaction http//www customsynthesls com/swet n html

I-I

nCI ...... 1l ....

.. Cl

tlO

OII

Hs ÿ_, r,_ Hÿ

Done

Iofl 217100 10 56AM

Named Reaction hÿp//\v\vw customsynthesÿs conJtmmann html

TIÿ fllalqfl Rÿ ai"i"atl ÿ'e flle I'Itr,

i ) PIÿO2JI

;) ÿ:zo

H

Referelÿee TO-2, ÿ1, 111.36 (1956)

Done

I of I 2/7/00 10 56 AM

Named Reaction http//www custonasynthesls com/ulhnann html

U II manÿ7 Re ach ,311

.-..

I;i:''il ...... :" .....

F:.eferel'tce JACS, 103, 6460 (1981)

Done

1 of l 2/7/00 10 56 AM

Named Reaction http//www customsynthesls com/wackel html

VCacke r' Reaÿlon

1,ÿ20z

pdclÿ CuClz

/¢ HO

R

J

l

to 9 oF,'efereIt,-o J&Co, 100, 3ÿ17 ÿ1. 7,.,)

Done

1 of I 2/7/00 10 57 AM

Named Reaction http//www cuslomsynthesm com/whm ton html

WhaPtotq P',.e ac-'l:l o1,1

OH

ReNmnce JCK2, 26, 3615 (1961)

Done

1 of 1 2/7/00 10 57 AM

Named Reactton http//www customsynthesB corn/whiting html

Whltlnÿ P'e acÿ on

HOÿ ÿ_. (OH Laÿ,,.1H4

R' RRÿR

Refe.re.llce Helv glum hcÿa, 39, 454 (1956)

Done

1 ofl 2/7/00 10 57 AM

Named Reachon http//www ctlstomsyntlaesls com/wlchtelle html

Wlchtÿ rlÿ Rÿ actl ,an

II a H.ÿ,:,, ,!oH.-,

.÷ ..

(E) 1,3 chclfloro-2-butene

u

Refsreiÿce TL, 3+S'9 (1979)

Done

I of 1 2/7/00 l0 57 AM

Named Reaction http//www customsynthesls corn/wolff html

Woltÿ R'ÿ arrange m e nt

0l[ ""1 A

R'OH o

E'.--OH=C =00

R'NI-I2 NHR'

Rel%rence Comp Org Syn, & 887 (1991)

Done

1 of 1 2/7/00 10'57 AM

Named Reaction http//www custon3synthesls com/wolftklshnel html

I - . _,'Vo Iÿ-l',a sl-,t ,er" Reduÿ on

N H2 N H2

OH" FSÿ'-R

E'.eterÿ-llco ÿ-h:?l[lÿJ Oro o,L, ,,ÿl, 8, 537 ,: 199 lÿ

Done

1 ofl 2/7/00 l0 57 AM

Named Reaction http//www custonlsynthesls com/wlttlg html

"v\hÿlg Reactl on

o+ PhsP----CHR

..F;

lÿ2Iÿrexÿze Comp Oiÿ, 8yÿ, 1, 755 (1991)

Done

1 ofl 2/7/00 10 57 AM

Named Reaction http//www custonlsynthesls com/12wlthg htm l

,,\tlttlÿ lÿ'e ÿ'ranÿe me nt

t

/

RILl

R..L. D

Cr

Relÿmlwe _,Kngew Ctÿ.ra 91, 625 (1979)

Done

1 nt" 1 2/7/00 10 57 AM

Named Reaction h|lp//www customsynthesJs colrd23\vlthg html

,ÿ,ÿ - V',httL'ÿ Rearr'anÿement !

0...,.._.,.,.. R

I]aS8 . .:.::,-y FI

HO" "R

i', R,e.fei,itc,,, Colalo Oÿ6 8ylt, 3, 975 (199t)

t .....

Done