Lesson 3 Slide 3.1 What might cause this disease?.

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Page 1: Lesson 3 Slide 3.1 What might cause this disease?.

Lesson 3

Slide 3.1

What might cause this disease?

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Page 2: Lesson 3 Slide 3.1 What might cause this disease?.

Lesson 3

Slide 3.2

• Build up of fatty deposits on under skin and in arteries

Fatty Deposit

Coronary Artery: a heart artery

Fatty Deposit

Knees and Fingers

• Very high cholesterol in blood

• Chest pain and heart attacks at a young age

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Familial Hypercholesterolemia (FH) Symptoms

Page 3: Lesson 3 Slide 3.1 What might cause this disease?.

Lesson 3

Slide 3.3

Fatty Deposit

Fatty Deposits In Coronary Artery

Cross Section of Coronary Artery

• Artery wall injured by toxins from smoking, high blood pressure• Arteries harden and narrow due to fat accumulation• Blood flow is reduced• Oxygen supply to heart reduced• Can cause chest pain heart attack or death in severe cases

NormalTear in

artery wall

Fatty deposits made in

artery wall

Narrowed artery

blocked by blood clot

Why People With FH Have Heart Attacks

Page 4: Lesson 3 Slide 3.1 What might cause this disease?.

Lesson 3

Slide 3.4

nucleus

cell

inside cell

outside cell

Cholesterol in LDL

LDL Receptor

Plasma Membrane

Takes LDL into cell

cholesterol

Low density lipoprotein (LDL) Receptor

Page 5: Lesson 3 Slide 3.1 What might cause this disease?.

Lesson 3

Slide 3.5

Cell

Tissue

Liver (organ)

DNA

Nucleus

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LDL Receptor Where is DNA located?

Page 6: Lesson 3 Slide 3.1 What might cause this disease?.

Lesson 3

Slide 3.6

From a cell not dividingUNPACKED

From a just divided cellPACKED

nucleus

Condensed package

Chromosomes

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Lesson 3

Slide 3.7

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double helix

nucleus

Base Pairs

chromosome

Chromosomes are Single Pieces of DNA

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Lesson 3

Slide 3.8

From DNA sequence to Protein overview

From RNA sequence to protein - more detailhttp://www-class.unl.edu/biochem/gp2/m_biology/animation/gene/gene_a3.html

http://www-class.unl.edu/biochem/gp2/m_biology/animation/gene/gene_a2.html

http://www-class.unl.edu/biochem/gp2/m_biology/animation/gene/gene_a1.html

From DNA to RNA - more detail

How do genes provide instructions for building proteins?

Page 9: Lesson 3 Slide 3.1 What might cause this disease?.

Lesson 3

Slide 3.9

RNA

amino acid

Coding Amino Acids

Page 10: Lesson 3 Slide 3.1 What might cause this disease?.

Lesson 3

Slide 3.10

Key to Toobers Blue=positive charge (+)

K, R, HRed=negative charge (-)

D, EYellow=hydrophobic

A, V, L, I, P, M, F, WGreen=hydrophilic

G, S, T, N, Q, YWhite = cysteine

C

Page 11: Lesson 3 Slide 3.1 What might cause this disease?.

Lesson 3

Slide 3.11

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CYTOPLASM

NUCLEUS•

Summary: DNA to protein

Page 12: Lesson 3 Slide 3.1 What might cause this disease?.

Lesson 3

Slide 3.12

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From Cells to DNA movie


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