Less Cleaning, More GC/MS Results - Agilentwe started using the Agilent GC/MSD with JetClean, the...
Transcript of Less Cleaning, More GC/MS Results - Agilentwe started using the Agilent GC/MSD with JetClean, the...
Less Cleaning, More GC/MS Results Agilent JetClean self-cleaning ion source
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With innovative JetClean technology, your lab can:
– Increase instrument uptime. Fewer manual cleanings maximize productivity.
– Maintain data quality. A clean ion source ensures run-to-run reproducibility.
– Enhance operator convenience. Automated cleaning requires virtually no user intervention.
What’s more, JetClean technology accommodates any workflow. You can clean and analyze simultaneously, or clean when you’re not acquiring data. Either way, JetClean delivers more uptime, more great results, and more data for your dollar.
Matrix deposits inevitably build up during routine analysis. In the past, you would have to remove the ion source, scrub the lens and other components, put it all back together, and recalibrate the instrument.
Now, there’s a better way to clean your GC/MS ion source.
The patented Agilent JetClean self-cleaning ion source greatly reduces—or even eliminates—the need for source cleaning on Agilent single and triple quadrupole GC/MS systems. A controlled flow of hydrogen ensures that the ion source is kept free from contamination, protecting the integrity of your results. And there’s no disassembly required.
Keep Your Ion Source Clean—Automatically
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Replace the arduous task of manual source cleaning with effortless JetClean operation
With JetClean Without JetClean
Reduce or Eliminate Manual Source Cleaning
JetClean uses a carefully controlled hydrogen flow to keep the ion source free from contamination. So you get more consistent results.
Ion source comparison after hundreds of soil extract injections. With JetClean, no contamination was observed on the source and lenses, and consistent response was maintained.
Deposits were clearly present on the source without JetClean. These deposits impacted response stability and needed to be removed to maintain data quality.
EI/CI operational mode EI operational mode
JetClean fits the way you workThe flexible process supports two modes of operation accommodating different analyses.
Analysis Cleaning
He He H
Clean only
Analysis and cleaning
He H
Acquire and cleanTwo modes of operation1 2
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“Our laboratory carries out pesticide residue analysis with the Agilent 7000 GC/MS/MS… To satisfy SANCO-defined QA/QC specifications with [varied] samples, the GC/MS source usually had to be cleaned every two weeks. After installing the JetClean system, the frequency of the manual source cleaning has been greatly reduced. We now manually clean the source only once in every three months. This increased productivity and freed up operator time is greatly appreciated.”
– Jana Pulkrabova, PhD Head of the Department of Food Analysis and Nutrition University of Chemistry and Technology, Prague
More uptime and more great resultsApplicable for all the following markets and industries:
Energy & Chemicals
Clinical Research
Food Testing & Agriculture
Materials Testing & Research
JetClean
Environmental
Metabolomics
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We measured polyaromatic hydrocarbons (PAHs) in palm oil after a simple toluene extraction. Various concentrations of calibration, QC samples, and palm oil extracts were analyzed during a 5-day, 200-injection evaluation. The results show consistently remarkable linearity and precision, low detection limits, and unmatched robustness.
Maintain Reliable Data and Satisfy Demanding Quality-Control Criteria
Excellent linearity: calibration ranging from 1 to 100 ng/mL with R2 values > 0.997.
Quant and qualifier ion plots of Benzo[a]pyrene at 1 ng/mL. Robust signal and Gaussian peak shape were maintained during the study.
The area response of 1 μg/kg spiked palm oil extract remained stable during the 5-day study, resulting in less than 5% area response RSD.
Area %RSD (n=12) Benzo[a]anthracene Chrysene Benzo[b]fluoranthene Benzo[a]pyrene
Day 1 1.8 1.2 1.9 1.7
Day 5 2.9 4.3 2.8 4.9
Relative Concentration-0.15 -0.1 -0.05 0 0.05 0.1 0.15 0.2 0.25 0.3 0.35 0.4 0.45 0.5 0.55 0.6 0.65 0.7 0.75 0.8 0.85 0.9 0.95 1 1.05 1.1 1.15 1.2 1.25 1.3 1.35 1.4 1.45 1.5 1.55 1.6 1.65 1.7 1.75 1.8 1.85 1.9 1.95 2 2.05 2.1
Relat
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+ MRM (252.1 -> 252.1) CC11-J2.D
Acquisition Time (min)
23 23.05 23.1 23.15 23.2 23.25 23.3 23.35 23.4
Cou
nts 4x10
-0.1
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2.823.189 min.
+ MRM (252.1 -> 250.1) CC11-J2.D
Acquisition Time (min)
23 23.05 23.1 23.15 23.2 23.25 23.3 23.35 23.4
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nts 4x10
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23.189 min.
Ratio = 56.2 (87.2 %)
+ MRM (250.1 -> 248.1) CC11-J2.D
Acquisition Time (min)
23 23.05 23.1 23.15 23.2 23.25 23.3 23.35 23.4
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nts 3x10
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23.186 min.
Ratio = 8.7 (50.1 %)
Benzo[a]pyrene Day 1: R2 = 0.9976Day 5: R2 = 0.9972
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“We had to clean the ion source on our previous, non-Agilent GC/MS about once every two weeks. Since we started using the Agilent GC/MSD with JetClean, the source has been cleaned once in nine months. [That means] our instrument spends more time running samples and generating data—and our users spend less time having to remove, clean, and reinstall the source.”
– Dr. Noga Sikron Persi Ben-Gurion University Metabolomics Laboratory
Putting JetClean to the test in a high-throughput metabolomics labThe JetClean self-cleaning ion source delivered huge time savings when analyzing plant metabolites in a high-throughput research laboratory, without compromising data quality.
Manual cleanings per year
Without JetClean self-cleaning ion source With JetClean self-cleaning ion source*
January February March
April May June
July August September
October November December
January February March
April May June
July August September
October November December
X2
X2
X2
X2
X2
X2
X2
X2
X2
X2
X1X2
X2
Twenty-four cleanings per year
* Cleaning frequency depends on application
One cleaning per year
Cleaning frequency reduced by up to 90%
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See how much your lab could save
Potential cost savings you could achieve using JetClean
Cost FactorWithout JetClean
JetClean in Acquire-and-Clean Mode
JetClean in Clean-Only Mode
Number of manual cleanings or estimated cleanings per year
Labor (wage) expense per cleaning event
Yearly cleaning labor (wage) cost
Revenue loss per cleaning event (downtime)
Yearly revenue loss to cleaning (downtime)
Yearly “cleaning cost" (wages + revenue loss)
JetClean yearly savings
See for yourselfPlug in the numbers that are relevant to your lab, and see the actual impact JetClean can have on your operation.
Actual savings are dependent on the application
Number of manual cleanings per year
Operator time per cleaning event (in hours)
Hourly wages of operator
Number of samples per eight-hour shift
Revenue per sample
Instrument downtime due to cleaning and recalibration (in hours)
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How Much Could Your Lab Save by Cutting Cleaning Time by up to 90%?
Learn more: agilent.com/chem/jetclean
Request a quote, or find a local Agilent customer center in your country: www.agilent.com/chem/store
U.S. and Canada 1-800-227-9770 [email protected]
Europe [email protected]
Asia Pacific [email protected]
This information is subject to change without notice.
© Agilent Technologies, Inc. 2019 Published in the USA, June 10, 2019 5991-6873EN Rev. 2.0