Leprosy N Actinomycosis

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    07-May-2015
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its a lecture of 2nd mbbs students which i have taken in last week.. hope u will enjoy it

Transcript of Leprosy N Actinomycosis

  • 1.

2. Examples of Chronic Inflammation

  • Tuberculosis
  • Leprosy, Syphilis ,Cat scratch disease, Granuloma inguinale, Tularemia
  • Fungal- Actinomycosis, Blastomycosis, Cryptococosis
  • Parasitic- Schistosomiasis
  • Sarcoidosis, Crohns, Foreignbody.

3. ? TheOrganism? How it enters in the body? Which organs are affected? Changes in the organs, Gross & Microscopy Complications and fates of disease How to make a Diagnosis ? 4.

  • Leprosy ~
  • Hansens disease

5.

  • Mycobacterium leprae
  • less acid fast .

6.

  • Transmission
  • Slow communicable
  • Incubation period 3 yrs

Slow transmission 7.

  • Route:
  • Direct contact

8.

  • Organs involved

9. Classification

  • Lepromatous
  • Tuberculoid

10.

  • T Lymphocytes
  • IFN-Gamma
  • Macrophages
  • epitheloid
  • giant cells .

11. ModifiedRidley&Joplingsclassification 12.

  • TT Tuberculoid polar
  • BT Borderline tuberculoid
  • TI-- Tuberculoid indeinite
  • BB Mid borderline
  • LI Lepromatous indefinite
  • BL Borderline lepromatous
  • LL Lepromatous polar

13.

  • Other types:
  • Pure neural
  • Histoid
  • Indeterminate

14. Lepromatous leprosy Symmetrical,Multiple,Hypopigmented lesions Leonine faces Pts Immunity down Sensory deficit less severe 15. 16. Histology

  • Foamy cellsin the dermis,
  • separated from Epidermis
  • byClear zone

17. 18. Tuberculoid leprosy

  • Single or few asymmetrical ,
  • Sensory impairment
  • Histology
  • Tubercle,
  • dermal nerves,
  • No clear zone, few bacilli

19. 20. Lab Diagnosis

  • To show the organism
  • Skin clipping
  • Stains-
  • ZN, Fite Faraco,
  • Gomori methenamine silver

21.

  • Culture

22. 9 Banded Armadilo 23. 24. Reactions in Leprosy

  • Lepra type I
  • Lepra type II

25. Lepra type I

  • Upgrading reaction
  • Downgrading reaction

26.

  • TT Tuberculoid polar
  • BT Borderline tuberculoid
  • TI-- Tuberculoid indeinite
  • BB Mid borderline
  • LI Lepromatous indefinite
  • BL Borderline lepromatous
  • LL Lepromatous polar

27. Lepra type 2

  • Erythema nodosum Leprosum
  • In Lepromatous patient
  • after treatment
  • Tender nodules, fever, synovitis,
  • Lymphnode enlargement

28. Lepromin test 29. 30. 31.

  • Not
  • for Diagnosis

32.

  • For classifying Leprosy
  • Depending onimmune response .
  • 24-48Fernandez
  • 3-4 wks Mitsuda reaction

33. 34. Baba Amte 35. 36. 37. Actinomycosis 38.

  • Mycosis
  • Is it a fungus?
  • No

39.

  • AnaerobicB acteria
  • Actinomycetes israelii.
  • Commensal organism.
  • Endogenous infection.

40. Types depending on sites

  • Cervicofacial
  • Thoracic
  • Abdominal
  • Pelvic

41. 42. 43. 44.