LegActifNatural ingredient

for the treatment of tired legs

Blood circulation stimulator

Technical specifications

LegActif 7234

PROPERTIES Blood circulation stimulatorIncreases blood circulation by 31%

Anti-edema. Edema reduction:Reduced skin thickness by 0.45 mm.Reduced leg contour by 0.5 cm and calf contour by 0.3 cm.

ACTIVE MOLECULES Goldenrod extract (rutin)Lemon peel extract (naringin and hesperidin)Butcher's broom extract (ruscogenin)

APPEARANCE LiquidColor: very dark brown

SOLUBILITY Soluble in aqueous solutions

RECOMMENDEDDOSE 0.5-1.5%

Formulation

Revitalizing gel for tired legs

A

B

C

D

INCI / PCPC

Acrylates/ C10-30 Alkyl Acrylate CrosspolymerGlycerinAqua (Water)Disodium EDTAPreservative

TriethanolamineAqua (Water)

LEGACTIFTM

Oleth-20Parfum (Fragrance)Aqua (Water)Preservative

TriethanolamineAqua (Water)

% (w/w)

0.405.00

86.050.100.80

0.051.00

1.500.650.303.000.50

0.250.40

provitalgroup.com

LegActif

LegActif is a complex ofplant active ingredients(Goldenrod, Lemon andButcher's broom) aimed atrelieving tiredness andheaviness in the legs.

Toxicological information

This product has been evaluated according to theavailable toxicological information, based on safetyassays and bibliographical data. These data allowthe conclusion that using this ingredient, under thenormal conditions for the use of cosmetics and atthe recommended concentrations, is free of risks.

Cosmetic applications

Products for the treatment of tired legs.LegActif stimulates blood circulation, thusrelieving leg heaviness. Its anti-edemaactivity further provides calming,decongestant and anti-fatigue effects.

Edema reduction

Images correspond to one of the LegActif-treatedvolunteers.

LegActif reduced skin thickness by 0.45 mm, whichdemonstrated edema reduction.

Initial situation Final situation

Ultrasound images:

Centimetric measurements

-0.50

-0.40

-0.30

-0.20

-0.10

0.00

Red

uctio

nfro

m D

0 (c

m)

Legactif - calfPlacebo - calf

-0.50

0.00

Centimetric measurements

LegActif-treated volunteers showed clear 0.5 cm reductionin calf contour.

Qualitative evaluationQuestionnaire

90% of the volunteers reported immediate comfort after application.

80% of the volunteers reported reliefof leg tiredness.

70% of the volunteers reported decongestant effect.

70% of the volunteers reported longterm wellness.

Study carried out on:The legs of 10 volunteers treated with LegActif 1.5% and 10 volunteers treated with a Placebo.Two weeks, two daily applications.

Evaluated by using:Laser Doppler, Ultrasonography, Centimetricmeasurements and self-evaluation questionnaire.

Laser Doppler measurements: clear-cut improvement in blood circulation

Laser Doppler Flowmetry

Legactif 1.5%Placebo

-10

0

10

20

30

40

% v

aria

tion

as c

ompa

red

to C

ontr

ol

2.27% 1.27%

30.94%

-3.38%

D0 D14

LegActif-treated volunteers showed clear improvementin blood circulation. Blood flow increased by 31%as compared to Control.

In Vivo

Goldenrod(Solidago virgaurea L.)

Lemon(Citrus limonum L.)

Butcher's broom(Ruscus aculeatus L.)

Features and benefits

LegActif is a cosmetic active ingredient effective in thetreatment of tired legs. Its activity results from the combinedactions of its active principles: naringin, hesperidin, rutinand ruscogenin, which stimulate blood circulation andreduce edema.

Goldenrod

Lemon

Butcher’sbroom

LegActif

Component Active principle Main action

Rutin

Naringin andHesperidin

Ruscogenin

Anti-edema

Anti-edema

Blood circulationstimulator

LegActif action mechanism