Learning Objectives

Metabolic Abnormalities Associated With T2D

CV Events With PPAR-gamma Agonists

Effect of Fibrates on CV OutcomesA Systematic Review and Meta-analysis

ACCORD Lipid Hazard Ratios for the Primary Outcome

Pioglitazone Meta-analysisHeart Failure & MI

Dual PPAR a/g Agonists

AleCardioAleglitazar (PPAR a/g Agonist) in Patients With T2D and ACS

AleCardio Efficacy and Safety Outcomes

AleCardioGlycemic Control and Lipoprotein Effects

Genes Regulated by Glitazones

Older Antidiabetic Drugs and CV Benefit/Harm

SAVOR-TIMI 53Clinical End Points: Saxagliptin (DPP4 Inhibitor) vs Placebo

SAVOR-TIMI 53Hospitalization for Heart Failure Stratified by NT-

proBNP Quartiles

SAVOR-TIMI 53Safety Endpoints

EXAMINESafety End Points: Alogliptin (DPP4 Inhibitor) vs Placebo

EXAMINEHeart Failure Outcomes

Mechanism of Heart Failure

Ongoing CVD Outcomes Trials in Type 2 Diabetes

Clinical Trial Design Considerations

AlePreventAleglitazar in Patients With Stable CVD and

Glucose Abnormalities

Newer Antidiabetic Drugs & CV Risk Reduction

Concluding Remarks

Abbreviations

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