LabSat™ Frozen · 2019. 9. 24. · 8 small volume reservoirs (1.5 / 2 ml Eppendorf® tubes) 4...

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IVD LabSat™ Frozen Ultra-rapid automated IHC staining on frozen sections LabSat™ is a compact automated tissue staining instrument for intraoperative IHC. Only marketed in Europe.

Transcript of LabSat™ Frozen · 2019. 9. 24. · 8 small volume reservoirs (1.5 / 2 ml Eppendorf® tubes) 4...

Page 1: LabSat™ Frozen · 2019. 9. 24. · 8 small volume reservoirs (1.5 / 2 ml Eppendorf® tubes) 4 large volume reservoirs (50 ml Falcon® tubes) 1 waste bottle (250 ml) Electrical input:

IVD

LabSat™ FrozenUltra-rapid automated IHC staining on frozen sections

LabSat™ is a compact automated tissue staining instrument for intraoperative IHC.

Only marketed in Europe.

Page 2: LabSat™ Frozen · 2019. 9. 24. · 8 small volume reservoirs (1.5 / 2 ml Eppendorf® tubes) 4 large volume reservoirs (50 ml Falcon® tubes) 1 waste bottle (250 ml) Electrical input:

LabSat™  Frozen is operated through a simple, user-friendly computer interface:

• Fully automated solution: automated calibration as well as walk-away function at the end of the day

• Clear overview of the instrument status

• Reports generation for tracking purposes

• Pre-loaded IVD validated protocol: Pan-cytokeratin staining for frozen sections in 13 minutes

Software

Staining chipA single-use consumable chip. It is placed in the stainer and clamped against the tissue slide, creating a microfluidic chamber.

Distribution chipA consumable microfluidic chip which acts as a gateway, delivering reagents and buffers sequentially to the stainer/sample.

Reservoirs4 high volume reservoirs (50mL) for buffers, and 8 small volume reservoirs (2mL) for consumable reagents, among which, 3 for primary antibodies and 5 for LUNA Kit IHC detection system.

WasteThe instrument is equipped with a 250mL pressurized waste bottle to collect reagents after their use.

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LabSat™ Frozen is an automated staining instrument, based on a cutting-edge microfluidic technology, capable of performing IHC assays on frozen sections in as little as 12 minutes, while maintaining high staining quality and reproducibility. The ultra-fast turnaround time makes LabSat™ Frozen a great tool to provide timely and accurate responses, for intraoperative IHC consultations.

The instrument is used with the LUNA Kit IHC detection system and is open to any primary antibody of choice.

LabSat™ Frozen

IVD

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MelanA, frozen section of skin malignant melanomaTotal staining time: 14 minutes

LabSat™ features

Intraoperative IHCThe possibility of performing IHC assays for histopathological consultation during biopsy procedures brings a significant added value to the surgeon’s decision-making process.

Ultra-rapid turnaround timeThanks to a microfluidic technology called FFeX and a pressurized system, incubation times are dramatically reduced by accelerating the reagent flow inside the staining chamber.

High quality stainingsThe closed staining chamber allows ultra-rapid and uniform delivery of reagents onto the tissue section, producing homogenous signal intensity across the area of confinement. Short incubation times limit the exposure of the tissue to harsh conditions and prevent tissue degradation over prolonged assay times.

Compact & robust deviceLabSat™ is a Swiss-made automated stainer of small dimensions. This benchtop device is compatible with the space constraints of a frozen section room.

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Intraoperative IHC

A new diagnostic tool

The possibilities opened up by ultra-rapid IHC staining may allow physicians to test specific biomarkers during a biopsy procedure in order to reach more precise intraoperative diagnoses.

Intraoperative IHC can help reduce the number of additional interventions required and support decision-making, potentially improving patient outcomes.

Workflow

Biopsy arrival Grossing Freezing Cutting

Fixation

IHC

Mounting & viewing

Diagnosis & call surgeon

Fixation

H&E

Mounting & viewing

Diagnosis & call surgeon

Avg. time: <18 min

Avg. time: <10 min

H&E intraoperativeconsultation

IHC intraoperative consultation

Block

Primary Ab

Secondary Ab

Detection

Counterstain

LabSat™Frozen

TTF1, frozen section of non-small cell lung carcinomaTotal staining time: 14 minutes

Page 5: LabSat™ Frozen · 2019. 9. 24. · 8 small volume reservoirs (1.5 / 2 ml Eppendorf® tubes) 4 large volume reservoirs (50 ml Falcon® tubes) 1 waste bottle (250 ml) Electrical input:

Fast Fluidic Exchange TechnologyThe staining chip, core of the Fast Fluidic Exchange Technology (FFeX), creates a chamber over the tissue sample where the staining takes place.

In LabSat™ a pressurized system moves reagents through a network of microfluidic channels and delivers them into this closed chamber almost instantaneously.

CLOSED CHAMBER TEMPERATURE CONTROLLED

PRESSURE CONTROLLED

This micro-chamber enables the homogenous incubation of reagents on the tissue

Reagents are delivered to the tissue through active flow

Fine-tuning of temperature conditions is key to achieve a high performance of stainings

HIGH STAINING PRECISION

ULTRA-RAPID

OPTIMIZED

Prof. Dr. med Alex Soltermann

Surgical PathologyUniversity Hospital Zürich

The technology is very promising for obtaining more homogenous and quantitative immunohistochemistry across whole tumor section.

A unique microfluidic tissue processor

“

”

Reagents flow through microfluidic channels, entering and filling the staining chamber.

Located at the heart of the “Health Valley” in Switzerland, Lunaphore is a medtech company born as a spin-off of the Swiss Federal Institute of Technology with the vision of bringing –omics like approaches to tissue diagnostics and dedicated to innovate in cancer research and tissue diagnostics.

Lunaphore specializes in ultra-rapid and automated solutions, performing IHC/IF stainings. LabSat™ is the result of +10 years of research. The company has been recognized as one of the most innovative companies internationally.

About Lunaphore

PanCK, frozen section of breast carcinomaTotal staining time: 13 minutes

Page 6: LabSat™ Frozen · 2019. 9. 24. · 8 small volume reservoirs (1.5 / 2 ml Eppendorf® tubes) 4 large volume reservoirs (50 ml Falcon® tubes) 1 waste bottle (250 ml) Electrical input:

Instrument specificationsFEATURESApplications

Slide capacitySlide requirements

Tissue thickness requirementsStaining areaTemperature controlAvg. Staining timeDimensionsWeightCapacity

Installation requirements

Catalogue numbers

CAPABILITIESFixation: FSStaining: IHC 1 slideThickness: 1 mm / 0.04 in Width: 25 - 26 mm / 1 in Length: 75 - 76 mm / 3 in Positively charged3-10 μm 22 x 22 mm / 0.87 x 0.87 inp

12-18 min 22 (H) x 37 (D) x 45 (W) cm / 8.7 (H) x 14 (D) x 17.7 (W) in12.5 kg / 27.5 lb8 small volume reservoirs (1.5 / 2 ml Eppendorf® tubes)4 large volume reservoirs (50 ml Falcon® tubes)1 waste bottle (250 ml)Electrical input: 100-240V ~AC 50-60Hz 2.0AAir supply: 5-8 bars at 20 L/min (ISO 8573-1 - 1.4.4) (Compressor optionally included)LS02 - LabSatTM FrozenMK01 – Microfluidic Kit (25 Staining Chips, 5 Distribution Chips for 25 tests)DK01- LUNA Kit Anti-mouse HRP DAB - IHC Detection Kit for 50 stainings:• Peroxidase block• Protein block• Anti-mouse IgG HRP• DAB - sol. 1 and sol. 2• Hematoxylin

Only marketed in Europe.

Consumables

Microfluidic Kit

Includes the chips required to operate LabSat™ Frozen: 5 Distribution Chips and 25 Staining Chips.

Ref. MK01

LUNA Kit

Anti-mouse HRP DAB - IHC Detection Kit validated for IVD use with LabSat™

Ref. DK01

IVD

CK18, frozen section of intestine. Total Staining time: 13 minutes.

Page 7: LabSat™ Frozen · 2019. 9. 24. · 8 small volume reservoirs (1.5 / 2 ml Eppendorf® tubes) 4 large volume reservoirs (50 ml Falcon® tubes) 1 waste bottle (250 ml) Electrical input:

©2019 Lunaphore Technologies S.A. | LMK-072019-BROLFSLunaphore Technologies SA | EPFL Innovation Park, Building C | 1015 Lausanne, Switzerland

Rapid CK on frozen sectionsS. Brajkovic, D.G. Dupouy, L De Leval  and M.A.M. Gijs, “Microfluidics for rapid cytokeratin immunohistochemical staining in frozen sections”, Laboratory Investigation 97, pages 983–991, 2017.

Dramatic reduction of the number of ambiguous resultsA.T. Ciftlik, H-A. Lehr and M.A.M. Gijs, “Microfluidic processor allows rapid HER2 immunohistochemistry of breast carcinomas and significantly reduces ambiguous (2+) read-outs,” Proceedings of the National Academy of Sciences USA (PNAS), volume 110, no. 14, pp. 5363-5368, 2013.

Interested in LabSat™ Frozen?Get in touch with us!

[email protected]


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