Laboratory Animal Science

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New Edition of a Bestseller!

The IACUC HandbookThird EditionEdited by

Jerald SilvermanUniversity of Massachusetts Medical School, Worcester, USA

Mark A. SuckowUniversity of Notre Dame, Indiana, USA

Sreekant MurthyRowan University, Glassboro, New Jersey, USA

“… a comprehensive collection of best practices; all of which are compliant with the federal guidelines and requirements. The sections labeled"regulatory" have been reviewed by staff at NIH Office of Laboratory Animal Welfare (OLAW) and USDA APHIS/Animal Care (AC) for consistencyand compliance with the PHS Policy and the USDA Animal Welfare Act Regulations (AWAR). … Both NIH/OLAW and APHIS/AC commend theauthors and editors for their outstanding efforts and for moving the biomedical research community forward in its formulation of best practicesand commonly accepted professional guidance in this complex arena.”

—From the Introduction byDr. Patricia A. Brown, Director of the Office of Laboratory Animal Welfare

Dr. Chester A. Gipson, Deputy Administrator USDA/APHIS/Animal Care

Praise for the second edition:

“…. easy to read, complete with a multitude of reference material ... useful to any new IACUC members or members of IACUC who have addi-tional questions regarding policies and regulations concerning animal programs at their or other institutions.”

—Sandra L. Jex, DVM, ALN Magazine, Vol. 6, No. 4, May/June 2007

“... I highly recommend it for the libraries of all those who are part of an IACUC or contribute to IACUC support.”—Rebecca S. Schwiebert, D.V.M., Ph.D, C.A.C.L.A.M., American Journal of Veterinary Research, Vol. 69, No. 1

This Third Edition comprehensively addresses the significant changes in the pertinent regulatory environment and interpretation of applicablefederal laws, regulations, and policies. It provides multiple references and commentary on the new edition of the Guide for the Care and Use ofLaboratory Animals, the new AVMA Guidelines for the Euthanasia of Animals: 2013 Edition, and the Office of Laboratory Animal Welfare’s FrequentlyAsked Questions. The Third Edition also features an updated survey of IACUC practices from institutions around the United States, offering wis-dom gained from their experience. In addition, it includes a chapter that provides an international perspective on how animal welfare reviews canfunction in other countries.

Table of Contents:

Introduction.Origins of the IACUC. Circumstances Requiring an IACUC. Creation of an IACUC. Reporting Lines of the IACUC. General Composition of the IACUC and Specific Roles of the IACUCMembers. Frequency and Conduct of Regular IACUC Meetings. General Format of IACUC Protocol Forms. Submission and Maintenance of IACUC Protocols. General Concepts of Protocol Review. Amending IACUC Protocols. Continuing Review of Protocols. Justification for the Use of Animals. Justification of the Number of Animals to Be Used. Animal Acquisition and Disposition. Animal Housing, Use Sites, and Transportation. Pain and Distress.Euthanasia. Surgery. Antigens, Antibodies, and Blood Collection. Occupational Health and Safety.

Personnel Training. Confidential and Proprietary Information. General Concepts of the Program Review and Facility Inspection. Inspection of Animal Housing Areas. Inspection of Individual Laboratories. Inspection of Surgery Areas. Assessment of Veterinary Care. Laboratory Animal Enrichment. Animal Mistreatment and Protocol Noncompliance. Postapproval Monitoring. The European Ethical Review Framework: Collaborative Issues. Index.

Catalog no. K15383, May 2014, 827 pp., ISBN: 978-1-4665-5564-8, $89.95 / £57.99

Management, Compliance, and Animal Welfare

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Management, Compliance, and Animal Welfare

Bestseller!

Managing theLaboratory AnimalFacilitySecond EditionJerald SilvermanUniversity of Massachusetts Medical School,Worcester, USA

“I am pleased that Dr. Silverman has put outa second edition. I felt … that he was talkingdirectly to me—in his folksy style of presentation—about any one of thefacility issues I’ve faced over the years. The not-so-hypothetical GreatEastern University from his Lab Animal column is again used to help usaddress those management scenarios that we see each and every day. Formyself, I will assign reading the sections on per diem in my lab animalmanagement class to help my students better understand this oft timesdifficult topic. As well, Jerry has offered many insights and approaches tohelp both the new and experienced lab animal manager… .”

—Bruce W. Kennedy, MS RLATG CMAR, Compliance Associate, Research &Graduate Studies, California State Polytechnic University, Pomona, USA

A guide to providing high-quality management of laboratory animal facili-ties in a financially sound manner, this book promotes a basic understand-ing of management and leadership concepts in laboratory animal science.While retaining the focus of its predecessor, this edition contains more than100 pages of new and expanded material. It includes an entirely new chap-ter on leadership, a greatly expanded chapter on the management ofhuman resources, a new appendix on productivity goals and measure-ments, and a revised appendix on how to calculate per diem rates.

Catalog no. 55569, July 2008, 328 pp.ISBN: 978-1-4200-5556-6, $87.95 / £55.99

Also available as eBook

Animal Welfare inAnimal AgricultureHusbandry, Stewardship,and Sustainability inAnimal ProductionEdited by

Wilson G. PondCornell University, Ithaca, New York, USA

Fuller W. BazerTexas A&M University, College Station, USA

Bernard E. RollinColorado State University, Fort Collins, USA

Through a multidisciplinary approach, this book takes readers on a jour-ney through the complex maze of issues that surrounds animal welfaretoday. The text links current and historical uses of animals and our viewstoward them with the concept of sustainable agriculture, addressingthe role that welfare plays in a strong and viable food system.Contributors present their views on what constitutes genuine animalwelfare and how it is attained. They discuss topics including ethics, foodsafety, ecology, biotechnology, and the contributions of animals to soci-ety. Unique in its depth, breadth, and balance, this book underscoresthe need for dialog on animal welfare.

Catalog no. K12159, November 2011, 333 pp.ISBN: 978-1-4398-4842-5, $93.95 / £59.99

Also available as an eBook

Bestseller!

Management ofLaboratory AnimalCare and UseProgramsEdited by

Mark A. SuckowUniversity of Notre Dame, Indiana, USA

Fred A. DouglasPurdue University, West Lafayette, Indiana, USA

Robert H. WeichbrodNational Eye Institute, Bethesda, Maryland, USA

The management of biomedical research using animals has becomeincreasingly complex due to new technology, increased regulatoryoversight, and recognition of the need for animals free of disease anddistress. Providing both factual and theoretical information, the contentof this book is drawn from the substantial experience of authors whoare noted experts in the field. Laboratory animal management is a dis-cipline that is likely to experience continued growth and an increase incomplexity. This book presents the basic knowledge and informationneeded to meet typical professional challenges.

Catalog no. 2287, November 2001, 408 pp.ISBN: 978-0-8493-2287-7, $109.95 / £69.99


The COST Manual ofLaboratory AnimalCare and UseRefinement, Reduction, andResearchEdited by

Bryan HowardFormer Director of Animal Welfare, University ofSheffield, UK

Timo NevalainenUniversity of Kuopio, Finland

Gemma PerrettaItalian National Research Council, Santa Maria di Galeria, Italy

COST Action B-24 established four working groups to research and dis-cuss issues relevant to laboratory animal science. These included thehousing of animals, environmental needs, refinement of procedures,genetically modified animals, and cost-benefit analysis. Based on thegroups’ findings, The COST Manual of Laboratory Animal Care andUse: Refinement, Reduction, and Research provides a consensualEuropean view of best practices for individuals and institutions caringfor and working with laboratory animals.

Catalog no. K11184, October 2010, 439 pp.ISBN: 978-1-4398-2492-4, $93.95 / £59.99






Volume IThird EditionEssential Principles and PracticesEdited by

Jann Hau and Steven J. SchapiroNow in its third edition, topics in Volume Iinclude the history of animal research, ethicalconcerns, regulation and legislation, facilitiesand equipment, genetics, health monitoring,nutrient requirements and feeding schedules, statistical analysis, surgicaland non-surgical techniques, and anesthesia, as well as humane end-points and the treatment of pain and suffering in laboratory animals. Thebook presents more material on the international harmonization of prac-tices and on the continued implementation of the refinement, reduc-tion, and replacement of animal usage in laboratories.

Contents — Includes a 16-page full color insert:

The Contribution of Laboratory Animals to Medical Progress — Past, Present, and Future

Ethics of Animal Research, An Overview of Global Legislation,Regulation and Policies

Assessment of Animal Care and Use Programs and Facilities

Education and Training

Laboratory Animal Science and Service Organizations

Laboratory Animal Allergy and Zoonoses

Laboratory Animal Facilities and Equipment for Conventional, Barrier,and Containment Housing Systems

Laboratory Animal Genetics and Genetic Quality Control

Health Status and Health Monitoring

Nutrient Requirements, Experimental Design, and Feeding Schedulesin Animal Experimentation

Impact of the Biotic and Abiotic Environment on Animal Experiments

Experimental Design and Statistical Analysis

Common Nonsurgical Techniques and Procedures

Applications of Radio-Telemetry in Small Laboratory Animals

Immunization for Production of Antibodies

Laboratory Animal Analgesia, Anesthesia, and Euthanasia

Welfare Assessment and Humane Endpoints

Surgery: Basic Principles and Procedures

Microsurgical Procedures in Experimental Research

Postmortem Procedures

Alternatives: Refinement, Reduction and Replacement of Animal Usesin the Life Sciences

Generation and Analysis of Genetically Modified Mice

Physiological, Hematological, and Clinical Chemistry Parameters (including Conversion Factors)

Catalog no. 84550, December 2010, 740 pp.ISBN: 978-1-4200-8455-9, $149.95 / £95.00

Handbook of Laboratory Animal Science


Third Edition, Volumes I, II, and IIIEdited by

Jann HauUniversity of Copenhagen & Rigshhospitalet, Denmark

Steven J. SchapiroThe University of Texas, Bastrop, USA

Continuing to set a precedent for quality information in laboratory ani-mal science, the third edition of the Handbook of Laboratory AnimalScience brings together contributions from leading experts across theworld. The chapters in each volume can be read as a stand-alone textwithout the necessity to consult other chapters for information,although the entire handbook is an integrated text with respect to giv-ing an in-depth introduction to laboratory animal science.

With contributions from eminent scientists who share their knowledgeand hands-on expertise from their own research, these volumes are acritical resource for veterinary and biomedical researchers, laboratorymanagers and administrators, and other laboratory animal professionals.

Praise for previous volumes of the Handbook:

"[A] valuable reference book … for undergraduate and graduate labo-ratory animal science courses. … well organized and well referenced. Iwould highly recommend this book as a reference text for all scientistsusing traditional laboratory animal species … ."

— Contemporary Topics in Laboratory Animal Science

"Both volumes of this book are well written, user friendly…it fills a cur-rent void by collecting together current practices in the scientific use ofanimals. Each chapter is well referenced and the book would be a valu-able addition to the reference collections of animal facilities andresearch establishments."

— Bryan Howard, Animal Welfare

" … information of the highest quality. . . both volumes of this book willbe valuable additions to the shelves of any veterinary surgeon involvedin the field, either as a named vet or as a member of the multidiscipli-nary scientific team required in modern biomedical research."

— Paul Townsend, The Veterinary Record

"The text is quite easy to navigate using the chapter contents andindex. The photographs and tables are clear and well used throughout.…The vast scope of information that this handbook contains is diverse,informative, and quite useful. The strength of these volumes is in theirability to cover a broad range of topics yet in such detail. This set wouldbe an asset to the graduate student and researcher needing an excel-lent reference manual."

— Sandra L. Jex, Animal Lab News

“ … extremely well-written and clear. The chapters provide authorita-tive introductions to a wide range of animal models and, as such, it willbe a very useful resource for researchers, laboratory animal veterinari-ans and regulators, for those teaching laboratory animal science, aswell as to anyone with an interest in the variety of uses to which ani-mals are put in the biomedical sciences.

— Robert Hubrecht, UFAW, Wheathampstead, UK, Animal Welfare




Volume IIThird EditionAnimal ModelsEdited by

Jann Hau and Steven J. Schapiro

Biomedical research involving animalsremains essential for the advancement of themedical, veterinary, agricultural, and biologi-cal sciences. Following in the footsteps of itspredecessors, the Handbook of LaboratoryAnimal Science, Volume II, Third Edition:Animal Models explains the comparative considerations underlyingthe choice of animal species and strains in different research disciplines.

Efficient and humane experimental work with animals, in which subjects experience no avoidable pain and mental distress, requiresskillful and conscientious staff. To this end, scientists apply the three Rs:replacing experiments on live animals with alternative methods, reduc-ing the number of animals necessary to obtain valid results withinexperiments, and refining techniques to minimize the discomfort expe-rienced by the animal participants. This volume explores new develop-ments in animal research with these ideals in mind.

Features in this new edition:

• Presents contributions by international experts in their respectivefields

• Focuses on the pertinent comparative aspects in the multiple contexts in which laboratory animals are used

• Includes ten new chapters

• Examines spontaneous genetic mutants and the genetically modified animal models available within different research areas

• Contains full color throughout the book, with approximately 50 color images

Contents:Animal ModelsAnimal Models for Human BehaviorAnimal Models for Psychological DisordersAnimal Models in NeuroscienceInduced Animal Models of Parkinson’s DiseaseAnimal Models in Aging and Alzheimer’s DiseaseAnimal Models in Pain ResearchAnimal Models in Pharmacology and ToxicologyAnimal Models for Otolaryngological DisordersAnimal Models of Lung Physiology During AnesthesiaAnimal Models of Female Reproduction and Fetal DevelopmentAnimal Models in VaccinologyAnimal Models in Aids ResearchAnimal Models for the Study of Helicobacter InfectionAnimal Models in MycologyAnimal Models in Biodefense ResearchAnimal Models in Oral Health ScienceAnimal Models of Hearing Loss and Tinnitus

Catalog no. 84577, April 2011, 480 pp.ISBN: 978-1-4200-8457-3, $189.95 / £108.00


Volume IIIThird EditionAnimal ModelsEdited by

Jann HauUniversity of Copenhagen & Rigshospitalet,Denmark

Steven J. SchapiroThe University of Texas MD Anderson CancerCenter, Bastrop, USA

Building upon the success of the bestsellingHandbook of Laboratory Animal Science and complementingVolumes I and II of the third edition, this new volume completes thetask of providing a comprehensive overview of animal models in all bio-medical disciplines. The book covers most of the important lab animalscience bases. As with Volume II, this book focuses on the pertinentcomparative aspects of the many different contexts in which animalsare used as well as on the spontaneous genetic mutants and the genet-ically modified animal models available within different research areas.

• Provides a summary chapter on the humane use of animals inresearch

• Reviews the use of laboratory animals for the study of diseases ofthe different organ systems, for infectious diseases, and for humanbehavior

• Includes new chapters on the use of animal models for alcoholand drug abuse research and sleep disorders

• Presents new chapters on cardiovascular disorders, digestive disorders, and regenerative medicine

Contents:Animal Models of Spinal Cord InjuryAnimal Models for Tropical Parasitic DiseasesAnimal Models of Cardiovascular DiseaseAnimal Models of Sudden Infant Death SyndromeMore Animal Models of Developmental Processes andDevelopmental Disorders for Social Genomics and BeyondAnimal Models of Metabolic and Inflammatory DiseasesAnimal Models for Eye DiseasesAnimal Models of Human CancerReduction and Refinement Applied to Animal Models

Catalog no. K15351, December 2013, 334 pp.ISBN: 978-1-4665-5512-9, $119.95 / £76.99





Ideal for Animal Caretakers, Technicians, & Laboratory Animal Veterinarians

Amply illustrated with figures and tables, each book inthe 13-volume series is a single-source reference thatallows for the humane, healthy, and efficient handling oflaboratory animals. These reader-friendly volumes detailbasic information and common procedures for individu-als performing research with laboratory animals,

including duties of animal facility management, animalhusbandry, regulatory compliance, and technical proce-dures. They also provide possible sources and suppliersof animals, feed, sanitation supplies, cages, and researchand veterinary supplies.

Series Editor: Mark A. Suckow, University of Notre Dame, Indiana, USA

***New and Recent Additions to Our Bestselling Series***

Catalog no. 2499September 2013, 271 pp., Soft CoverISBN: 978-0-8493-2499-4$59.95 / £38.99

Catalog no. K12511 October 2012, 256 pp., Soft CoverISBN: 978-1-4398-5421-1$59.95 / £38.99

Catalog no. K11462December 2012, 406 pp., Soft CoverISBN: 978-1-4398-2986-8$59.95 / £38.99

Each Book Includes:• Important Biological Features • Husbandry • Management • Veterinary Care

• Experimental Methodology • Resources • Bibliography





Series Editor: Mark A. Suckow, University of Notre Dame, Indiana, USA

14-VOLUME SET • Catalog no. 2560, ISBN: 978-0-8493-2560-1, $749.95 / £479.00

The Laboratory Xenopus sp.

Catalog no. 91093, December 2009180 pp., Soft Cover

ISBN: 978-1-4200-9109-0$59.95 / £38.99

The LaboratoryZebrafish

Catalog no. K10378, December 2010274 pp., Soft Cover

ISBN: 978-1-4398-0743-9$59.95 / £38.99

The Laboratory RabbitSecond Edition

Catalog no. 91050, April 2010148 pp., Soft Cover

ISBN: 978-1-4200-9105-2$59.95 / £38.99

The Laboratory Guinea Pig

Second EditionCatalog no. K11598, June 2011

172 pp., Soft CoverISBN: 978-1-4398-3556-2

$59.95 / £38.99

The Laboratory Ferret Catalog no. K12861, March 2012

123 pp., Soft CoverISBN: 978-1-4398-6181-3

$59.95 / £38.99

The Laboratory Canine Catalog no. 2893, October 2006, 184 pp., Soft CoverISBN: 978-0-8493-2893-0, $59.95 / £38.99

The Laboratory SwineSecond Edition

Catalog no. K10783, February 2010138 pp., Soft Cover

ISBN: 978-1-4398-1528-1$59.95 / £38.99

The Laboratory Nonhuman PrimateCatalog no. 2562, September 2001, 288 pp., Soft CoverISBN: 978-0-8493-2562-5, $59.95 / £38.99

The Laboratory Hamster and GerbilCatalog no. 2566, December 1998, 168 pp., Soft CoverISBN: 978-0-8493-2566-3, $59.95 / £38.99

The Laboratory CatCatalog no. 2567, November 1997, 160 pp., Soft Cover

ISBN: 978-0-8493-2567-0, $59.95 / £38.99

The Laboratory Small RuminantCatalog no. 2568, March 1999,176 pp., Soft Cover

ISBN: 978-0-8493-2568-7, $59.95 / £38.99














Laboratory Animal Bacteriology

Coming Soon!

Handbook of Laboratory Animal BacteriologySecond EditionAxel Kornerup HansenUniversity of Copenhagen, Frederiksberg, Denmark

Dennis Sandris NielsenUniversity of Copenhagen, Frederiksberg, Denmark

About the First Edition:

“…this book provides precise methodology for the isolation and identification of bacteria that interfere with researchprotocols. It is logically organized, instructive, and progresses through animal sampling, bacterial culture, isolation, dif-ferentiation, and identification. … The book is a valuable guide to the bacteriological monitoring of rodent and rabbit research animal colonies.… It should be useful to laboratory animal health monitoring laboratories and to those needing overall information on how to perform labora-tory animal bacteriological procedures. It will also be of interest to facility managers, clinical veterinarians, veterinary pathologists, andresearchers interested in the management of organisms known to interfere with the colony health of rabbits and rodents used in research proto-cols”

—Contemporary Topics in Laboratory Animal Science, March 2000

This second edition of a bestseller covers how to isolate bacteria in laboratory rodents and rabbits to assist veterinary pathologists and other ani-mal caretakers in the management of these organisms. It emphasizes those bacteria known to interfere with research protocols, and offers meth-ods for isolation and differentiation among related bacteria. It also enables the user to isolate and identify bacteria that is a part of the normal floraof these animals. The book is for facility managers, clinical veterinarians, veterinary pathologists, and researchers.

The book provides information on the general aspects of bacteriology, how to sample and identify bacteria in the animals, and how these bacte-ria interfere with animal models and the methods used to investigate this. It then describes the various bacterial species to be found in laborato-ry rodents and rabbits. While this in the first edition was divided according to cultivation and Gram staining characteristics, which was the stan-dard at the time, it is now divided according to a more systematic phylum based approach, which the new molecular biological methods havemade standard. This means that bacterial species, previously regarded as closely related, now may appear in two different phyla. Also, these chap-ters cover a range of bacteria identified to be of importance in laboratory rodents and rabbits over the last 10-15 years.

Features:

• Defines, for each bacteria: the habitats, clinical importance, morphology, relevant media, physical, biochemical, and immunological characteristics, and molecular biology

• Includes new chapters on the Mechanisms Behind Bacterial Impact on Animal Models and on a Systematic Overview of Bacteria

• Expands greatly the chapter on Cultivation Methods and the Identification of Bacteria

• Offers tips on differentiating between related species of bacteria and explains proper staining techniques and serology

• Describes all bacterial species which may be isolated during routine investigations in rodents and rabbits

Selected Contents:

Laboratory Animal Bacteriology – the Past, the Presence and the Future. Sampling Animals for Bacteriological Examination. Cultivation and Identification of Bacteria. Immunological Methods. Molecular Biology Based Methods for Microbiota Characterization. Mechanisms behind Bacterial Impact on Animal Models. Systematic Classification of Bacteria. Firmicutes. Bacteroidetes. Proteobacteria. Actinobacteria. Spirochaetae. Tenericutes. Verrucomicrobia, Deferribacteres, Fusobacterium and TM7. Appendixes: Producers of Reagents for Laboratory Animal Bacteriology. Biosafety Levels for Microbiological Laboratories.

Catalog no. K22007, November 2014, 300 pp., ISBN: 978-1-4822-1544-1, $119.95 / £76.99




Laboratory Mouse and Laboratory Rat Procedural TechniquesJohn J. Bogdanske, BA; Scott Hubbard-Van Stelle, AS, CVT, RLATG; Margaret Rankin Riley, BS; and Beth M. Schiffman, BS, CVLT, RLATGResearch Animal Resources Center (RARC), University of Wisconsin, Madison, USA

“Laboratory Rat and Laboratory Mouse Procedural Techniques Manual and DVD are short, easi-ly read/watched manuals that review the very basic handling for the animal care technician throughthe clear use of discussion and accompanying photographs, enhanced with a clear, understandableDVD demonstrating each procedure discussed. Not only is the safety of the laboratory specimen of con-cern, but even more importantly, the safety of the human laboratory technicians and researchers. Thereader is assumed to have fundamental laboratory rodent training in place. This is not meant as a pri-mary training tool but to review and refresh existing understanding. Each of the texts is similar inorganization and content which conveniently aids in navigation of topics.”

—Sandra L. Jex, DVM, Animal Lab News

Buy the Set and Save! Two Manuals and Two DVDs Catalog no. K12298, November 2010, 192 pp., Soft Cover / Comb Binding, ISBN: 978-1-4398-5050-3, $108.00 / £68.99

Also available individually:

Laboratory Mouse Procedural TechniquesCatalog no. K12294, November 2010, 100 pp., Soft Cover

ISBN: 978-1-4398-5042-8, $59.95 / £38.99

Laboratory Rat Procedural TechniquesCatalog no. K12295, November 2010, 92 pp., Soft Cover

ISBN: 978-1-4398-5044-2, $59.95 / £38.99

Procedural Techniques

Suturing Principles and Techniques in LaboratoryAnimal SurgeryJohn J. Bogdanske, Scott Hubbard-Van Stelle, Margaret Rankin Riley, and Beth M. SchiffmanResearch Animal Resources Center (RARC), University of Wisconsin, Madison, USA

This color manual and accompanying DVD introduce the basic principles of, and the materials and instru-ments required for, suturing and wound closure on animals in a research or veterinary facility. It covers instru-mentation holding and handling; needle types and applications; and suture material, packaging, and appli-cations. It also provides in-depth coverage of various suture patterns and associated principles for proper knottying, including step-by-step descriptions, video clips with narration, and handouts for each suture pattern.

• Addresses multiple learning styles by using the written word, video, audio, and color pictures for eachsuture pattern

• Contains high-quality pictures of each technique that depict step-by-step instructions for each suturepattern

• Includes a DVD with narrated video clips demonstrating each technique

• Focuses on providing a quality instructional resource for teaching and demonstrating suturing techniques

• Comes in a spiral-bound format that makes it easy to use in a laboratory setting

• Offers guidance on vessel ligation, the use of skin staples, and choosing appropriate needle and suture material

Selected Contents:Instrumentation. Needle Types. Suture Material. Suture Pattern Descriptions and DVD Narration. Suture Patterns: Handouts. Study Breaks:DVD Narration. Suture Considerations for Exotics and Other Species. Glossary. Index.

Catalog no. K15275, June 2013, 123 pp., Soft Cover/Comb Binding, ISBN: 978-1-4665-5343-9, $59.95 / £38.99






New!

Non-Clinical VascularInfusion TechnologyVolume IIThe TechniquesEdited by

Owen P. GreenLeVerts Ltd., Peterborough, UK

Guy HealingAstraZeneca, Cheshire, UK

Following in the footsteps of the original Handbook of Pre-clinicalContinuous Intravenous Infusion, this completely revised edition answersthe needs of researchers and technicians by providing step-by-stepinstructions for a wide range of infusion techniques delivered to multi-ple species. With sections devoted to rats, mice, rabbits, dogs, minip-igs, nonhuman primates, and juvenile animals, this thorough textincludes procedures for multidose infusion toxicity and reproductivetoxicology studies and provides guidance on the use of a variety ofequipment, including tail cuffs, harnesses, and implanted buttons.

• Presents step-by-step procedures and practical tips covering awide range of common animal models, augmented by the liberaluse of illustrations

• Emphasizes best practices in accordance with the 3Rs—reduction,refinement, and replacement of animal usage in laboratories

• Discusses pathology within each species chapter and relevantequipment in each chapter

• Covers catheterization techniques, including entrance and exitlocations

• Offers detailed information on surgical preparation for primatesand minipigs, along with advice about the use of preoperativeanesthesia, postsurgical analgesics, and antibiotic administration,as well as valuable input on surgical suite design

Selected Contents:Rat. Mouse. Dog. Primate. Rabbit and Reproductive Studies. Minipig.Juvenile Animals.

Catalog no. K13451, December 2013, c. 344 pp.ISBN: 978-1-4398-7445-5, $119.95 / £76.99Also available as an eBook

Buy the Set and Save!

Non-Clinical Vascular Infusion TechnologyTwo Volume Set: Science and Techniques

Catalog no. K13447, January 2014, c. 520 pp.ISBN: 978-1-4398-7440-0, $179.95 / £114.00


Non-Clinical Vascular Infusion Technology

NEW!

Non-Clinical VascularInfusion TechnologyVolume IThe ScienceOwen P. GreenLeVerts Ltd., Peterborough, UK

Guy HealingAstraZeneca, Cheshire, UK

With the evolution of vascular infusion technology, its use in the pre-clinical safety assessment of pharmaceuticals has become increasinglywidespread. Hence, a need has developed for a single source on the sci-entific principles behind this technology. This book brings together cur-rent knowledge and underlying practices from around the world tohelp refine the procedures and enhance the understanding of infusiontechnology. It addresses the physical and physiological aspects includ-ing body fluid dynamics, physico-chemical factors, vascular infusiondynamics, formulation-specific considerations, and equipment compat-ibility.

• Identifies and shares best practices for non-clinical vascular infu-sion

• Relates physico-chemical and physiological principles to vascularinfusion delivery

• Comments at various points throughout each chapter on scientificprinciples related to vascular infusion delivery

• Presents modern practices and procedures in line with up-to-dateequipment development

• Provides guidance on choices for the most acceptable methodolo-gies from an animal welfare perspective

• Offers recommendations for in-life assessments in order to moni-tor the success or problems with the vascular infusion delivery

• Makes comparisons with human data in many areas

Selected Contents:Body Fluid Dynamics. Physico-Chemical Factors. Vascular InfusionDynamics. Formulation Considerations. Prestudy analytical assess-ments: Equipment compatibility. Annex: Common excipients andvehicles.

Catalog no. K13453, September 2013, 215 pp.ISBN: 978-1-4398-7449-3, $99.95 / £63.99Also available as an eBook

"Owen Green and Guy Healing have shown the importance of the 3Rs in infusiontechnology at international meetings and in producing this book.”

—From the Foreword by Kathryn Chapman, Head of Innovation and Translation, the National Centre for the Replacement, Refinement and Reduction of Animals in Research




11

Bestseller!

Swine in theLaboratorySurgery, Anesthesia,Imaging, and ExperimentalTechniques, Second EditionEdited by

M. Michael SwindleMedical University of South Carolina, Charleston,USA

To diminish the learning curve associated with using swine as mod-els, Swine in the Laboratory: Surgery, Anesthesia, Imaging, andExperimental Techniques, Second Edition provides practical tech-nical information for the use of swine in biomedical research. Itfocuses on models produced by surgical and other invasive proce-dures, supplying the basic principles for performing experimentswith an organ or system of interest. This edition contains never-before-published images, additional chapters on toxicology andradiobiology, sections on anesthesia and perioperative care, andexpanded details on anatomy and endoscopy.

Includes a DVD with three-dimensional, full-color images

Contents:Biology, Handling, Husbandry, and AnatomyAnesthesia, Analgesia, and Perioperative CareWound Closure and Integument Gastrointestinal Procedures Liver and Biliary SystemPancreas and SpleenUrinary System and Adrenal GlandsGeneral Principles Of Surgery and Surgical AnatomyNephrectomyReproductive SystemCardiothoracic and Vascular Surgery/Chronic IntravascularCatheterization Head and Neck Surgery/Central Nervous System Musculoskeletal System and Orthopedic Procedures Cardiovascular Catheterization, Electrophysiology, and ImagingLaboratory Procedures Endoscopic, Laparoscopic, and Minimally Invasive Surgery Xenotransplantation and Transgenic Technologies Toxicology Radiobiology Imaging Techniques: CT, RI and Pet Scanning Ossabaw Island Miniature Swine: Cardiometabolic SyndromeAssessment

Catalog no. 9278, March 2007, 496 pp.ISBN: 978-0-8493-9278-8, $169.95 / £107.00


The Minipig inBiomedical ResearchEdited by

Peter A. McAnulty, Anthony D. Dayan,Niels-Christian Ganderup, and Kenneth L. Hastings"…the breadth and scope of this bookextends into other disciplines by exploringminipigs as a disease model for a myriad ofconditions including diabetes mellitus, osteo-porosis, atherosclerosis, and oral disease. …The text does an excellent job of explainingwhat is currently known while also highlighting areas where standardprotocols are lacking and areas where more research is needed, such ascharacterizing and sequencing the porcine genome. This may spur fur-ther investigations into the biology of minipigs by increasing researcherconfidence and comfort level working with this species in the future."

—Kristy Conn, Laboratory Animal Practitioner, Vol. 45, No. 3, December 2012

"Overall, this book will be a very useful reference source on the minipig foranyone involved with this species in biomedical research. It has elementsthat will also be of value to toxicologists, and what information is not cov-ered in the book can probably be found through the references provided."

—Guy Healing, AstraZeneca, UK, BTS Newsletter, Issue 41, December 2012

Features:• Describes best practices in husbandry, transport, and experimentation• Explains and illustrates clinical, practical,

and experimental techniques and procedures• Provides many examples of successful use of the minipig in basic

and regulatory toxicity studies of drugs and devices• Discusses clinical and physiological findings and laboratory values

in health and disease• Includes a 48-page color insert

The Minipig in Biomedical Research is a comprehensive resource forresearch scientists on the potential and use of the minipig in basic andapplied biomedical research and the development of drugs and chemi-cals. The book is written by acknowledged experts in the field and drawson the authors’ global contacts and experience with regulatory author-ities and the pharmaceutical and other industries. This accessible manu-al explores the biological, scientific, and practical uses of the minipig inthe laboratory. Its coverage extends from the minipig’s origins, anatomy,genetics, immunology, and physiology to its welfare, health, and hus-bandry; practical dosing and examination procedures; surgical tech-niques; all areas of toxicity testing; and the uses of the minipig as a dis-ease model. Regulatory aspects of its use are also considered.

Contents:

Origin and Management of the MinipigHistory and Development of Miniature, Micro- and MinipigsWelfare and Experimental Usage of the MinipigPharmacology and ADME Studies in the MinipigSafety Assessment in the Minipig – Principal Body SystemsGenetics and ImmunologyDisease ModelsRegulatory Perspective and Use of the Minipig in DevelopingMarketed ProductsNew Horizons and Perspectives

Catalog no. K10559, December 2011, 662 pp.ISBN: 978-1-4398-1118-4, $189.95 / £89.00


For more information and complete contents, visit www.crcpress.com

Swine



Forthcoming!

Pathology of the DevelopingMouseA Systematic ApproachEdited by

Brad BolonThe Ohio State University, Department ofVeterinary Sciences, USA

This volume provides a complete referenceon the design, analysis, and interpretation of abnormal findings thatmay be detected in developing mice before and shortly after birth. Inparticular, this book is designed specifically to be not only a "how to do"manual for developmental pathology experimentation in mice but,more importantly, a "how to interpret" resource for pathologists andother biomedical scientists faced for the first or hundredth time withdefining the significance of distorted features in some fantastic murinedevelopmental monstrosity.

The topics covered in this volume include a full range of subjectsencountered when building and wielding a developmental pathologytool kit:

• Baseline anatomic and physiologic traits of developing mice

• Principles of good experimental design and statistical analysis formouse developmental pathology studies

• Procedures for anatomic pathology examinations

• Methods for clinical pathology testing, to assess the biochemicaland cellular composition of tissues and fluids

• Options and protocols for in situ molecular pathology analysis

• Guides to the interpretation of anatomic pathology and clinicalpathology changes in the animal

Contents:

Introduction. The Case for Developmental Pathology andDevelopment Pathologists. Fundamentals of Mouse DevelopmentalBiology. Essentials of Mouse Genetics and Nomenclature.Indispensable Terminology for Mouse Developmental PathologyStudies. Normal Development of the Mouse Embryo and Extra-embryonic Membranes. Teratogens and Teratogenic Mechanisms inMouse Developmental Pathology. Experimental Methods in MouseDevelopmental Pathology. Principles of Experimental Design forMouse Developmental Pathology Studies. Necropsy Sampling andData Collection for Studying the Anatomy, Histology and Pathologyof Mouse Development. Clinical Pathology Analysis in the DevelopingMouse. Histotechnological Processing of Developing Mice. GeneDistribution Studies in Developing Mice. Protein Localization inDeveloping Mice. Quantitative Morphological Assessment in MouseDevelopmental Pathology Studies. Ultrastructural Evaluation ofDeveloping Mice. Three-Dimensional Imaging in MouseDevelopmental Pathology Studies. Analytical Practices for MouseDevelopmental Pathology. Pathology of the Developing Mousefrom Conception to Weaning. Pathology of the Placenta. MouseDevelopmental Pathology Assessments in High-ThroughputPhenogenomic Facilities. A Statistical Analysis Primer for MouseDevelopmental Pathology Studies. Index.



Histologic Basis ofMouse EndocrineSystem DevelopmentA Comparative AnalysisMatthew KaufmanUniversity of Edinburgh (Retired), Scotland

Alexander Yu. NikitinCornell University, Ithaca, New York, USA

John P. SundbergThe Jackson Laboratory, Bar Harbor, Maine, USA

• Aids in the analysis of genetically engineered mice with embryonic abnormalities

• Contains more than 100 high-magnification color plates organized in folders by organ name.

• Includes scanned serial sections of embryos at defined stages of post conception

• Illustrates similarities and differences between the mouseendocrine system and that of other species

Catalog no. 88181, October 2009, 240 pp.ISBN: 978-1-4200-8818-2, $164.95 / £106.00



Mice and Rats

Experimental Surgical Models in the Laboratory RatEdited by

Alfredo Rigalli and Veronica Elina Di LoretoRosario National University, Argentina

Written for biomedical researchers, this man-ual on experimental surgery in rats, summa-rizes a series of techniques that have been applied at the Bone BiologyLaboratories at the School of Medicine at Rosario National University inArgentina. Stopping short of an exhaustive analysis of the techniques,the manual describes the basis of each surgical technique, the neces-sary materials—including catheters, precautions to consider, themethodology to apply, and the possible results to be obtained. Thedescriptions of each technique appear with diagrams and pictures.

Catalog no. 93266, May 2009, 232 pp.ISBN: 978-1-4200-9326-1, $154.95 / £99.00





13

Stereotaxic andChemoarchitecturalAtlas of the Brain of the Common Marmoset (Callithrix jacchus)Craig D. Hardman and Ken W. S. AshwellUniversity of New South Wales, Sydney, Australia

"… the most comprehensive collection of marmoset brain images gath-ered in one reference to date. … The accompanying DVD presents theplates in vivid color, increasing the image detail and their portability.The book’s inclusion of neural structure volumetric data, MRI images,stereotaxic references, and immunohistochemically mapped chemoar-chitectural sections qualifies it as a seminal marmoset brain reference."

—Stephen Denny, Laboratory Animal Practitioner, Vol. 46, No. 2, June 2013

The Stereotaxic and Chemoarchitectural Atlas of the Brain of theCommon Marmoset (Callithrix jacchus) is the most detailed atlas ofthe marmoset brain available. An essential tool for researchers develop-ing more effective therapies for disabling and debilitating neurologicaldisorders, the book contains:

• Fully delineated, high-quality (400x magnification) images ofNissl-stained, acetylcholinesterase histochemically stained and parvalbumin, calbindin and neurofilament immunohistochemicallystained coronal and sagittal sections, as well as structural magneticresonance images (MRIs) for direct comparisons

• Line diagrams with delineations of all cortical and subcorticalstructures, with grid overlays so the precise position of each structure can be located stereotaxically relative to the interauralline and infraorbital margin

• Quantitative data regarding volume and cell number of many ofthe structures delineated in the atlas, regularly updated on anaccompanying website

• Standard nomenclature widely used in the Paxinos group ofatlases, allowing users to compare and contrast homologousnuclei in different species using the major available atlases

The book combines modern imaging (MRI) with an accurate stereo-taxic and chemoarchitectonic section atlas, making the fullest use ofavailable technologies. The companion DVD includes all the images infull color. Designed by publishing neuroanatomists, this book/DVD willbe a cornerstone in marmoset brain research for years to come.

Contents:IntroductionEcology, Behavior and Evolution of the Common MarmosetThe Marmoset in Neuroscience ResearchKey Features of This BookAnimals and Ethical ConsiderationsMethods: MRI, Perfusion and Tissue ProcessingImaging, Principles of Delineation and AbbreviationQuantitation of Volumes and Neuronal Populations of Motor NucleiBases for Delineation of Specific Regions and NucleiReferencesNamed Structures and AbbreviationsIndex of Atlas PlatesAtlas Plates

Catalog no. K11718, January 2012, 515 pp.ISBN: 978-1-4398-3778-8, $179.95 / £114.00


Pocket Handbook of Nonhuman Primate ClinicalMedicineEdited by

Angela CourtneyUniversity of California, Davis, USA

Sources of clinical treatment information onnonhuman primates are traditionally scat-tered across journals, textbooks, confer-ences, personal conversations, and more. However, when a clinicianon the treatment floor is faced with a patient needing immediatetreatment, an informed decision must be made expeditiously.

An alternative to conducting a literature search in time-sensitive situa-tions, Pocket Handbook of Nonhuman Primate Clinical Medicinesupplies guidance and initial direction on diagnosis and treatment,including working doses based on past case experience. The frank, to-the-point nature of the text makes readers feel as if they had justasked a colleague how to approach a clinical problem and obtained aquick, “what you need to know” answer. The chapter authors drawon personal experience to describe commonly encountered clinicalconditions and how to treat these cases—including not only the dosbut also the don’ts. This format gives readers easy access to clinicalsigns, diagnostic criteria, and options for treatment.

This volume is a convenient, concise, case-based handbook written byand for clinicians in charge of the diagnosis and treatment of nonhu-man primate patients. Available in both print and electronic formats,this handbook saves readers from having to wade through pages ofdata and case studies to find answers when time is a factor on theclinic floor.

Features:

• Provides formulary and drug dosages, special precautions, andimportant notations

• Discusses common diseases and clinical problems and outlinestreatment based on current medicine

• Presents full-color illustrations • Fits in a lab coat pocket for easy reference

Contents:Anesthesia in Nonhuman PrimatesPain ManagementWounds and Wound CareBasic Fluid TherapyManagement of Gastrointestinal/Abdominal ConditionsThorax ConditionsBacterial, Mycotic, Viral, and Parasitic InfectionsGestational Concerns: When to Intervene and What to DoDentistry in NhpsDermatologic and Ophthalmologic ConditionsStrategies for Managing Behavior ProblemsFormularies: Drug DosagesIndex

Catalog no. K13021, October 2012, 232 pp.Soft Cover, ISBN: 978-1-4398-6728-0, $99.95 / £63.99


For more information and complete contents, visit www.crcpress.com

Nonhuman Primates



Toxoplasmosis ofAnimals and HumansSecond EditionJ.P. DubeyUSDA/ARS, Beltsville, Maryland, USA

In the two decades since the publication ofthe first edition of this volume, there hasbeen an explosion of knowledge concerningT. gondii and toxoplasmosis.

Still used extensively as a cell model, its genome has recently been pub-lished, making it a subject of even greater scientific interest. Keeping theorganizational style that made the previous edition so popular, this sec-ond edition now includes:

• Expanded information on the cultivation, maintenance, and preservation of T. gondii

• Expanded information on the cell biology and molecular biology ofthe parasite

• Reviews of all literature from the past 20 years for each domesticanimal

• Summarized information on the worldwide prevalence of toxoplas-mosis in pregnant women

Catalog no. 92367, November 2009, 336 pp.ISBN: 978-1-4200-9236-3, $159.95 / £102.00


A Color Atlas ofComparativePathology ofPulmonaryTuberculosisEdited by

Franz Joel Leong, Veronique Dartois, and Thomas DickNovartis Institute for Tropical Diseases, Singapore

Written by notable authorities from the several disciplines involved withtuberculosis (TB) research, this book is the first pictorial histopathologyatlas with annotations on TB. Addressing serious and growing concernsover the outbreak and treatment of TB, the atlas introduces TBhistopathology to students, scientists, and doctors. The atlas takes theunusual approach of covering multiple species histopathology. It pro-vides a simple, annotated, and visual presentation of the comparativehistopathology of TB in human and animal models. The editors havecompiled information that helps TB scientists distinguish among thefeatures of all major animal models available. They provide guidance forselecting the best animal model(s) to answer specific questions and totest the efficacy of drug candidates.

Catalog no. K11591, September 2010, 236 pp.Soft Cover, ISBN: 978-1-4398-3527-2, $129.95 / £84.00


Animal Models of DiabetesSecond Edition, Frontiers in ResearchEdited by

Eleazar ShafrirHadassah University Hospital, Jerusalem, Israel

" … provides excellent background and spe-cific information on each model … ."

— Leanne Alworth, in Laboratory AnimalPractitioner

“I recommend those veterinary pathologists read this book beforebeginning experiments using diabetic model animals.”

— Akira Yabuki, Veterinary Pathology

Providing researchers with current information regarding the use ofmodels in experiments, this text covers both Type 1 and Type 2 dia-betes. It compiles relevant time-saving information on most, if not all,current well-recognized models for both types of diabetes, includingmice, rats, mini-pigs, and Rhesus monkeys, and provides extensive ref-erences for more in-depth study. Among several other topics, it dis-cusses nutritionally diabetes-prone animals and considerations ofinsulin resistance and obesity. It also addresses the importance of recentfindings on pathogenesis of diabetes and its complications in relationto human disease.



Biodefense Research Methodology and Animal ModelsSecond EditionEdited by

James R. SwearengenNational Biodefense Analysis and CountermeasuresCenter, Frederick, Maryland, USA

Significant advances have been made in animal model development forbiological research since the publication of the first edition of this vol-ume, and the ramifications of the FDA’s Animal Efficacy Rule havebecome better understood in the scientific community. With eachchapter completely updated with the latest research findings, this vol-ume spans the spectrum of coverage from basic research to advanceddevelopment of medical countermeasures. Topics discussed include ahistory of biological agents as weapons, concepts and strategiesinvolved in biowarfare and bioterrorism, animal models in biodefenseresearch, and infectious disease aerobiology. The book also presentsstudies involving a range of specific diseases and toxins.

Catalog no. K11643, February 2012, 415 pp.ISBN: 978-1-4398-3632-3, $135.95 / £86.00



Animal Models Diseases





Translational Pain ResearchFrom Mouse to ManEdited by

Lawrence KrugerUniversity of California, Los Angeles, USA

Alan R. LightUniversity of Utah, Salt Lake City, USA

Bringing together recent advances in mod-ern neuroscience regarding genetic studiesin mice and humans and the practicality ofclinical trials, this cutting-edge work effectively bridges the gapbetween basic research and patient care by humanely examiningrodent models for pain associated with bone cancer, osteoarthritis,fibromyalgia, and cardiac episodes. Among other topics, it addressesgroundbreaking technical advances in tract tracing, endocannabinoids,cannabis, gene therapy, siRNA gene studies, and the role of glia,cytokines, P2X receptors, and ATP.

Catalog no. K10609, November 2009, 432 pp.ISBN: 978-1-4398-1209-9, $169.95 / £124.00


Viral HemorrhagicFeversEdited by

Sunit K. SinghMolecular Biology Unit, Faculty of Medicine,Institute of Medical Sciences, Banaras HinduUniversity (BHU), Varanasi, India

Daniel RuzekBiology Centre ASCR- Institute of Parasitology,Ceske Budejovice, Czech Republic

Viral hemorrhagic fevers (VHFs) are a groupof febrile illnesses caused by RNA virusesfrom several viral families. These infectious viruses lead to a potentiallylethal disease syndrome characterized by fever, malaise, vomiting,mucosal and gastrointestinal bleeding, edema, and hypotension. Thefour viral families known to cause VHF disease in humans naturallyreside in an animal reservoir host or arthropod vector. This volume pres-ents the most current information on each virus. It examines the feverscaused by these viruses, their mechanisms for spreading, their molecu-lar pathogenesis, host pathogen immune interactions, and detection,treatment, and prevention.

Catalog no. K13962, July 2013, 596 pp.ISBN: 978-1-4398-8429-4, $149.95 / £95.00


Neurobiology ofChemicalCommunicationEdited by

Carla Mucignat-CarettaUniversity of Padova, Italy

Exploring the role of the chemical senses inmediating intraspecific communication, thisvolume examines the structure, anatomy,electrophysiology, and molecular biology ofpheromones. It discusses how chemical sig-nals work on different mammalian and non-mammalian species andincludes chapters on insects, Drosophila, honey bees, amphibians,mice, cats, and cattle. It also explores the controversial topic of humanpheromones. An essential reference for students and researchers in thefield of pheromones, this is also an ideal resource for those working onbehavioral phenotyping of animal models and persons interested in thebiology/ecology of the different species.



PhenomicsEdited by

John M. HancockCambridge University, UK

Phenomics is the new discipline of usingstandardized measurement techniques tocharacterize the phenotypic effects of ran-dom or systematic genome modifications(for example randomly generated mutationsor systematic gene knockouts). Thisapproach is now being used in an increasingrange of species and systems. In this book,experts working in phenomics in most of the major species and systemsthat are currently being studied present overviews of the field from theirdifferent, but overlapping perspectives.




Neuroscience





AnimalHematotoxicologyA Practical Guide for Toxicologists and Biomedical ResearchersG.O. EvansA. George Owen and Company, UK

This book is designed to help new entrantsto the fields of laboratory animal hematol-ogy and toxicology, where the challenges are stimulating and the“rules” for human hematology do not always apply. In a clear, cohe-sive, and concise manner, the book covers the full range of the disci-pline, from basic principles to diagnostic evaluation.

Chapters are written to cover the three main blood cell types—ery-throcytes, leukocytes, and thrombocytes—and potential toxic effectson these cells. A chapter on immunotoxicology is included as this sci-entific discipline is closely aligned to hematology. Other chapters aredevoted to preanalytical and analytical variables that affect animalstudies.

Information has been collated from published papers, textbooks,and unpublished data: references are provided at the end of eachchapter or in Appendix A, where readers are provided with some keyreferences on published reference ranges for laboratory animals.

Features:

• Provides information on main laboratory animal species with tables of reference values

• Includes a chapter on bone marrow evaluation containing material on micronucleus tests in genetic toxicology

• Explores differences in cell counting techniques

Contents:HemopoiesisPre-analytical Factors, Analytical Factors, StatisticsBone Marrow EvaluationIron, Tranferrin, Vitamin B12, Folate, and ErythropoietinErythrocytic DisordersLeukocytic DisordersHemostasisImmunological Toxicology

Catalog no. 80091, July 2008, 224 pp.ISBN: 978-1-4200-8009-4, $96.95 / £59.99


Animal ClinicalChemistryA Practical Handbook for Toxicologists and BiomedicalResearchers, Second EditionEdited by

G.O. EvansA. George Owen and Company, UK

In addition to tests recommended by regulatory authorities, this glob-ally relevant resource includes information about clinical chemistry testsas well as hepato-, nephro-, cardio-, and endocrine toxicity. It also cov-ers pre-analytical and analytical variables, which play a far more impor-tant role in interpreting data from animal studies as compared tohuman studies when variables can be well controlled with less physio-logical effect. Furthermore, this edition takes its discussion of biomark-ers to the next level, exploring newer and related investigations, suchas metabolomics/NMR and multiplex technology.

• Addresses normal and abnormal clinical chemistry of lab animals• Provides more in-depth coverage of acute phase response proteins

and cytokine measurements• Includes current biochemical investigation techniques such as

metabolomics/NMR and multiplex technology• Explores troponins, lipids, and electrolytes

Contents:General EnzymologyAssessment of HepatotoxicityAssessment of NephrotoxicityAssessment of Gastrointestinal and Pancreatic ToxicitiesFluid Balance, Electrolytes, and Mineral MetabolismAssessment of Cardiotoxicity and MyotoxicityProteinsLipidsAssessment of Endocrine ToxicityAssessment of NeurotoxicityPreanalytical VariablesAnalytical Variables and BiosafetyData Processing and InterpretationReferences for Laboratory Animal Clinical Chemistry DataAppendices:References for Laboratory Animal Clinical Chemistry DataSI Unitage and Conversions"Expectable" Ranges for Plasma/SerumGeneral AbbreviationsSome Common Biochemical Abbreviations



Chemistry and Hematotoxicology




Bestseller!

Infectious Diseases and Pathology of ReptilesColor Atlas and TextEdited by

Elliott JacobsonUniversity of Florida College of Veterinary Medicine,Gainesville, USA

“… an excellent resource. … should sit sideby side on the shelves of those working in reptile medicine or patholo-gy. This book will prove informative and beneficial for students, resi-dents, clinicians, and pathologists working with reptiles.”

— Dr. J. A. St. Leger, Seaworld, San Diego, in Veterinary Pathology

"Every so often, a book arrives on the scene that is destined to becomea classic, and that time has come again. Elliot R. Jacobson … has com-piled a book of such scope and magnitude that it will likely grace thereference library collection of virtually every veterinarian and patholo-gist working with reptiles … .”

— Zoo News

Featuring 1,200 high-quality color photos of normal anatomy and his-tology, as well as gross, light, and electron microscopic images ofpathogens and diseases, this exceptionally comprehensive atlas pro-vides definitive information on every known infectious disease affectingreptiles. Beginning with a thorough review of reptile biology, anatomy,and histology, leading authorities then address specific topics such asimmunology, circulating inflammatory cells, necropsy techniques,pathogen identification and isolation, molecular diagnosis, and serodi-agnostics. The atlas also catalogs specific pathologies due to viruses,bacteria, fungi, and parasites. Included are numerous never-beforepublished electron microscope findings of reptile lesions.

Contents:Overview of Reptile Biology, Anatomy, and HistologyReptile ImmunologyCirculating Inflammatory CellsReptile Necropsy TechniquesHost Response to Infectious Agents and Identification of Pathogens inTissue SectionIdentifying Reptile Pathogens Using Electron MicroscopyMolecular DiagnosticsSerodiagnosticsViruses and Viral Diseases of ReptilesBacterial Diseases of ReptilesMycotic Diseases in ReptilesParasites and Parasitic Diseases of ReptilesIsolation of Pathogens



Animal Behavior Desk ReferenceA Dictionary of AnimalBehavior, Ecology, andEvolution, Third EditionEdward M. BarrowsGeorgetown University, Washington, D.C., USA

“This reference is a tremendous undertakingin thoroughly researching the terminologyand citing references for additional clarifica-tion of concepts and phrases.”

—Sandra L. Jex, DVM, Animal Lab News

"This dictionary departs from other standard dictionaries … in that everydefinition is drawn from a cited reference; many have several. This allowsreaders who want to see how these terms were used in the context of ascholarly article or monograph to find the full citation in the bibliographyat the back of the book and to retrieve the reference in a library. Definitionsare, however, complete enough to give readers the full meaning of terms... Highly recommended for all college, university, and public libraries."

—R. G. Sabin, Rice University, CHOICE

Features:

• Discusses how definitions impact the way people communicate

• Serves as an access point to the primary literature through extensive referencing

• Presents variations in meaning that have developed for many different terms over time

• Indicates controversies regarding the meanings of many terms with author-date citations

Providing a common ground and platform for precise scientific com-munication in animal behavior, ecology, evolution, and relatedbranches of biology, this volume contains more than 800 new termsand definitions, 48 new figures, and thousands of additions andimprovements.

Using a dictionary format to present definitions in a standard, easilyaccessible manner, the book emphasizes conceptual terms andfocuses on nouns, rather than verbs or adjectives. Term hierarchiesare presented with bulleted entries and terms with multiple defini-tions are included as superscripted entries. All sources are cited andmost are paraphrased to conform to uniform style and length.

The dictionary also includes nontechnical and obsolete terms, syn-onyms, pronunciations, and notes and comments, as well as ety-mologies, term originators, and related facts. Appendices addressorganism names, organizations, and databases.

Devoted to the precise and correct use of scientific language, thisthird edition of a bestselling standard enables students and scientistsalike to communicate their findings and promote the efficientadvancement of science.

Catalog no. K11649, April 2011, 800 pp.ISBN: 978-1-4398-3651-4, $159.95 / £99.00


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Laboratory Animal Science

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