Lab 1 CVS pathology - medicinebau.com
Transcript of Lab 1 CVS pathology - medicinebau.com
Lab 1 CVS pathology
ي الطلبة أعزائ
هذه الورقة تحتوي فقط على ما قيل عن هذه الصور زيادة عن النظري وأي معلومة ي لن تجدوها مذكورة هنا ولكنكم مطالبون بمعرفتها ي العملى
ي النظري وتكررت ف
ذكرت ف بالتأكيد
Mitral valve leaflet Warty (verrucous) vegetations 1-2mm in size at the closure line
Acute rheumatic endocarditis
Normal cardiac muscle Normal cardiac muscle
Aschoff body lymphocytes
Caterpillar cell: Bulky cytoplasm, large nucleus with open chromatin and central ribbon of dark chromatin
Multinucleated giant cell
Acute rheumatic myocarditis
Left atrium, dilated
Commissural fusion
Thickening and irregularity (fibrosis)
Chronic rheumatic heart disease (fishmouth/buttonhole mitral stenosis)
Chronic rheumatic heart disease (shortening, thickening and fusion of chordae tendineae)
Neovascularization on mitral leaflet (a chronic change)
Chronic rheumatic heart disease (fishmouth/buttonhole mitral stenosis)
Chronic rheumatic heart disease in aortic cusps (thickening and irregularity)
White areas of MI in ventricular wall
Surrounding areas of congestion
Normal muscle
White area of MI in the anterior left ventricular wall and in the septum
The MI involves the 3 wall layers (transmural MI)
Thick dark eosinophilic wavy lines in the cytoplasm of cardiac myocytes (contraction bands…abnormal
proteins) = contraction band necrosis
No nuclei (ghost cells)…coagulative necrosis These nuclei are of WBCs carried in
blood
Early MI
Contraction bands…contraction band necrosis
Acute inflammatory cells in MI
MI…necrotic myocytes with blood in between
Severe inflammation in necrosis of cardiac myocytes…too many neutrophils
Nuclear fragments of neutrophils (karyorrhexis)…due to high activity of neutrophils and increased apoptotic activity in them
Area of MI
Rupture site in MI
Large clot surrounding the heart due to the hemorrhage due to the rupture
Normal cardiac muscle
Granulation tissue started to form in an area of MI (repair (organization) process)
Small thin-walled newly formed blood vessels
Inflammatory cells like macrophages in addition to fibroblasts in between the vessels …little amount of new collagen
Fibrosis (mature collagen and small nuclei of fibrocytes)
Remaining cardiac myocytes
This area was MI in the past
Like slide 15
Like slide 15
Cardiomegaly due to dilation of all champers (dilated cardiomyopathy)…the heart appears globular
Thinned area of ventricular wall due to previous MI (fibrosis)
Dilated cardiomyopathy
Thinned wall due to previous MI (fibrosis)
Aneurysm is formed due to the weak wall
Nonspecific changes in dilated cardiomyopathy Variable fibrosis
Hypertrophic myocytes
atrophic myocytes
Hypertrophic cardiomyopathy Hypertrophy is more in the septum (if it is equal in all parts it’s described: concentric)
Banana shaped luminal narrowing
Perl’s or Prussian blue stain showed positivity (blue) in a case of hemosiderosis in dilated cardiomyopathy (may also cause restrictive)
Amorphous pink material suggestive of amyloidosis
Congo red stain under polarized light microscopy (apple green light is positive for amyloid)
These dark nuclei are those of lymphocytes in between the myocytes (lymphocytic myocarditis)…typical of viral myocarditis
Reference: Webpath