L I S T O F P U B L I C A T I O N S Suad Efendic FULL PAPERS 1 Efendic S The investigation of human mycosis on experimental animals. Medicinar 1:3-9, 1961 (in Croatian) 2 Efendic S, Lazic N Effect of oxytetracyclin (geomycin) on the pregnancy and the embryo nic development in rat. Medicinar 2:5-18, 1961 (in Croatian) 3 Efendic S, Turina M L'influence de l'hialuronidase dans la syphilis precoce des lapins. Radovi Med Fak (Zagreb) 10:75-80, 1962 (in Croatian; summary in French) 4 Taborsky J, Efendic S, Ivancevic I Action of 1-oxo-3(3'sulfamoyl-4'chlorophenyl)-3-hydroxyisoindoline on the dextrane oliguria by rats. Acta Pharmacol Jug 12:147-150, 1962 (in Croatian; summary in English) 5 Efendic S Histological and histochemical differentiation of kidney, liver and gut in fetuses of control rats and rats with hypersecretion of adrenal glands. Thesis (in Croatian for Master of Science Degree; Zagreb 1966) 6 Milkovic K, Efendic S, Paunovic J, Ronkulin J, Dublibic V, Milkovic S Effect of the autonomous transplanable pituitary mammotropic tumour on the pregnancy and the embryonic development in rat. Bull Sci (Zagreb) Section A 11/4-6:107-358, 1966 7 Sekso M, Efendic S, Ozegovic B, Hitrec V The value of copper determination in diagnosing thyroid disease. An Bolnice ”Dr M Stojanovic” 5:356-358, 1966 (in Croatian; summary in English) 8 Sekso M, Efendic S, Uravic M, Hitrec V Diagnostic value of the determination of cholesterol in thyroid disorder. Lij Vjes 88:249-253, 1966 (in Croatian; summary in English) 9 Sekso M, Padovan I, Efendic S, Hitrec V, Spaventi S Gamascintigraphy in preoperative diagnostics of diseases of the thyroid gland. Symp ORL Iug 1-2:101-113, 1966 (in Croatian; summary in English) 10 Milkovic S, Milkovic K, Efendic S Significance of maternal corticosteroids in fetal adrenal development and organogenesis. Gen Comp Endocrinol 10:240-246, 1968 11 Bozovic L, Efendic S Renin secretion in vitro from rat kidney cortex slices. Acta Endocrinol (Copenh) 60:550-554, 1969

12 Cerasi E, Efendic S, Luft R Role of adrenergic receptors in glucose-induced insulin secretion in man. Lancet 2:301-302, 1969 13 Östman J, Efendic S, Arner P Catecholamines and metabolism of human adipose tissue. Acta Med Scand 186:241-246, 1969 14 Östman J, Efendic S Alpha-adrenergic receptors in human omentum? Lancet 1(7587): 202, 1969 15 Östman J, Efendic S, Arner P Chlorpropamide and lipid metabolism of rat and human adipose tissue in vitro. Acta Med Scand 187:11-16, 1970 16 Östman J, Efendic S Catecholamines and metabolism of human adipose tissue II. Effect of isopropylnoradrenaline and adrenergic blocking agents on lipolysis in human omental adipose tissue in vitro. Acta Med Scand 187:471-476, 1970 17 Efendic S Catecholamines and metabolism of human adipose tissue III. Comparison between the regulation of lipolysis in omental and subcutaneous adipose tissue. Acta Med Scand 187:477-483, 1970 18 Efendic S, Östman J Catecholamines and metabolism of human adipose tissue IV. Influence of glucose on catecholamine induced lipolysis in human omental adipose tissue in vitro. Acta Med Scand 187:485-491, 1970 19 Efendic S, Östman J Catecholamines and metabolism of human adipose tissue V. Studies on the incorporation of glucose-1-14C into lipids and the re-esterification of FFA by human omental tissue in vitro. Acta Med Scand 187:493-502, 1970 20 Efendic S Studies on the effect of catecholamines on human adipose tissue metabolism. Thesis. Stockholm: Karolinska Institutet, 1970 21 Efendic S Influence of prostaglandin E1 on lipolysis induced by noradrenaline, isopropylnordrenaline, theophylline, and dibutyryl cAMP in human omental adipose tissue in vitro. Acta Med Scand 187:503-507, 1970 22 Alm B, Efendic S, Löw H Effect of lipolytic and antilipolytic agents on the uptake of 47Calcium into rat adipose tissue in vitro. Horm Metab Res 2:142-146, 1970 23 Efendic S, Alm B, Löw H Effects of Ca2+ on lipolysis in human omental adipose tissue in vitro. Horm Metab Res 2:287-291, 1970 24 Rosenqvist U, Efendic S, Jereb B, Östman J Influence of the hypothyroid state on lipolysis in human adipose tissue in vitro. Acta Med Scand 189:381-384, 1971

25 Cerasi E, Efendic S, Luft R, Östman J Blood glucose and plasma glycerol response to epinephrine infusion in normal and prediabetic subjects. Acta Med Scand 189:489-493, 1971 26 Rosenqvist U, Efendic S Stimulatory effects in vitro of prostaglandin E1 on noradrenaline-induced lipolysis in subcutaneous adipose tissue from hypothyroid subjects. Acta Med Scand 190:341-345, 1971 27 Cerasi E, Luft R, Efendic S Antagonism between glucose and epinephrine regarding insulin secretion. Acta Med Scand 190:411-417, 1971 28 Efendic S, Cerasi E, Luft R Role of glucose in arginine-induced insulin release in man. Metabolism 20:568-579, 1971 29 Efendic S, Cerasi E, Luft R Arginine-induced insulin release in relation to the cyclic AMP system in man. J Clin Endocrinol Metab 34:67-72, 1972 30 Cerasi E, Luft R, Efendic S Effect of adrenergic blocking agents on insulin response to glucose infusion in man. Acta Endocrinol (Copenh) 69:335-346, 1972 31 Cerasi E, Luft R, Efendic S Decreased sensitivity of the pancreatic beta cells to glucose in prediabetic and diabetic subjects. Diabetes 21:224-234, 1972 32 Cerasi E, Efendic S, Luft R Dose-response relation between plasma-insulin and blood-glucose levels during oral glucose loads in prediabetic and diabetic subjects. Lancet 1:794-797, 1973 33 Efendic S, Cerasi E, Luft R Effect of blockade of the α-adrenergic receptors on insulin response to glucose infusion in prediabetic subjects. Acta Endocrinol (Copenh) 74:542-547, 1973 34 Efendic S, Cerasi E, Luft R Quantitative study on the potentiating effect of arginine on glucose-induced insulin response in healthy, prediabetic, and diabetic subjects. Diabetes 23:161-171, 1974 35 Efendic S, Luft R, Grill V Effect of somatostatin on glucose induced insulin release in isolated perfused rat pancreas and isolated rat pancreatic islets. FEBS Lett 42:169-172, 1974 36 Hökfelt T, Efendic S, Johansson O, Luft R, Arimura A Immunohistochemical localization of somatostatin (growth hormone release- inhibiting factor) in the guinea pig brain. Brain Res 80:165-169, 1974 37 Luft R, Efendic S, Hökfelt T, Johansson O, Arimura A Immunohistochemical evidence for the localization of somatostatin-like immunoreactivity in a cell population of the pancreatic islets. Med Biol 52:428-430, 1974 38 Efendic S, Luft R Studies on the inhibitory effect of somatostatin on glucose induced insulin release in the isolated perfused rat pancreas. Acta Endocrinol (Copenh) 78:510-515, 1975

39 Efendic S, Luft R Studies on the mechanism of somatostatin action on insulin release in man. I. Effect of blockade of α-adrenergic receptors. Acta Endocrinol (Copenh) 78:516-523, 1975 40 Hökfelt T, Efendic S, Hellerström C, Johansson O, Luft R, Arimura A Cellular localization of somatostatin in endocrine-like cells and neurons of the rat with special references to the A1 -cells of the pancreatic islets and to the hypothalamus. Acta Endocrinol (Copenh) /Suppl 200/80:5-41, 1975 41 Efendic S, Grill V, Luft R Inhibition by somatostatin of glucose induced 3':5'-monophosphate (cyclic AMP) accumulation and insulin release in isolated pancreatic islets of the rat. FEBS Lett 55:131-133, 1975 42 Efendic S, Luft R, Sievertsson H Relative effects of somatostatin and two somatostatin analogues on the release of insulin, glucagon and growth hormone. FEBS Lett 58:302-305, 1975 43 Efendic S, Cerasi E, Luft R Effect of phentolamine and preperfusion with glucose on insulin release from the isolated perfused pancreas from fasted and fed rats. Diabetologia 11:407-410, 1975 44 Hökfelt T, Johansson O, Efendic S, Luft R, Arimura A Are there somatostatin-containing nerves in the rat gut? Immunohistochemical evidence for a new type of peripheral nerves. Experienta 31:852-854, 1975 45 Moberg PJ, Efendic S, Hall K, Fryklund L Amniotic-fluid somatomedin A and fetal C.N.S. damage. Lancet 1:1016, 1976 46 Efendic S, Lins PE, Sigurdsson G, Ivermark B, Granberg PO, Luft R Effect of somatostatin on basal and glucose induced insulin release in five patients with hyperinsulinaemia. Acta Endocrinol (Copenh) 81:525-529, 1976 47 Efendic S, Luft R, Claro A Studies on the mechanism of somatostatin action on insulin release in man. II. Comparison of the effects of somatostatin on insulin release induced by glucose, glucagon and tolbutamide. Acta Endocrinol (Copenh) 81:743-752, 1976 48 Efendic S, Claro A, Luft R Studies on the mechanism of somatostatin action on insulin release. III. Effect of somatostatin on arginine induced release of insulin and glucagon in man and perfused rat pancreas. Acta Endocrinol (Copenh) 81:753-761, 1976 49 Efendic S, Cerasi E, Luft R, Gladnikoff G Potentiation of glucose induced insulin release by glucose in the isolated pancreas of fed and fasted rats. Diabetes 25:949-954, 1976 50 Lins PE, Efendic S Hyperglycemia induced by somatostatin in normal subjects. Horm Metab Res 8:497-498, 1976 51 Claro A, Grill V, Efendic S, Luft R Studies on the mechanism of somatostatin action on insulin release. IV. Effect of somatostatin on cyclic AMP levels and phosphodiesterase activity in isolated rat pancreatic islets. Acta Endocrinol (Copenh) 85:379-388, 1977

52 Efendic S, Lins PE, Luft R, Sievertsson H, Westin-Sjödal G Studies on the mechanism of somatostatin action on insulin release. V. Effect of somatostatin analogues on arginine induced release of insulin and glucagon from the perfused rat pancreas. Acta Endocrinol (Copenh) 85:579-586, 1977 53 Uvnäs-Wallensten K, Efendic S, Luft R Vagal release of somatostatin into the antral lumen of cats. Acta Physiol Scand 99:126-128, 1977 54 Efendic S, Luft R, Pernow B Effect of substance P on arginine-induced insulin and glucagon release from the isolated perfused rat pancreas. In: Substance P, von Euler US, Pernow B, eds. New York: Raven Press, 1977, pp 241-245 55 Falkmer S, Elde RP, Hellerström C, Petersson B, Efendic S, Fohlman J, Siljevall J-B Some phylogenetical aspects on the occurrence of somatostatin in the gastro-entero-pancreatic endocrine system. A histological and immunohistological study combined with quantitative radioimmunological assays of tissue extracts. Arch Histol Jpn /Suppl/40:99-117, 1977 56 Petersson B, Elde R, Efendic S, Hökfelt T, Johansson O, Luft R, Cerasi E, Hellerström C Somatostatin in the pancreas, stomach and hypothalamus of the diabetic Chinese hamster. Diabetologia 13:463-466, 1977 57 Wahren J, Efendic S, Luft R, Hagenfeldt L, Björkman O, Felig P Influence of somatostatin on splanchnic glucose metabolism in postabsorptive and 60-hour fasted humans. J Clin Invest 59:299-307, 1977 58 Uvnäs-Wallensten K, Efendic S, Luft R Inhibition of vagally induced gastrin release by somatostatin in cats. Horm Metab Res 9:120-123, 1977 59 Uvnäs-Wallensten K, Efendic S, Luft R The occurrence of somatostatin-like immunoreactivity in the vagal nerves. Acta Physiol Scand 102:248-250, 1978 60 Uvnäs-Wallensten K, Lundberg JM, Efendic S Dopaminergic control of antral gastrin and somatostatin release. Acta Physiol Scand 103:343-345, 1978 61 Johansson C, Wisen O, Kollberg B, Uvns-Wallensten K, Efendic S Effects of intragastrically administered somatostatin on basal and pentagastrin stimulated gastric acid secretion in man. Acta Physiol Scand 104:232-234, 1978 62 Holm I, Thulin L, Samnegård H, Efendic S, Tyden G Anticholeretic effect of somatostatin in anesthetized dogs. Acta Physiol Scand 104:241-243, 1978 63 Efendic S, Luft R, Cerasi E Quantitative determination of the interaction between epinephrine and various insulin releasers in man. Diabetes 27:319-326, 1978

64 Thulin L, Samnegård H, Tyden G, Long DH, Efendic S Efficacy of somatostatin in a patient with carcinoid syndrome. Lancet 2:43, 1978 65 Lins PE, Efendic S, Löw H Somatostatin decreases urinary calcium excretion. Lancet 2:687, 1978 66 Uvnäs-Wallensten K, Efendic S, Luft R Release of gastrointestinal hormones into the duodenal lumen of cats. Horm Metab Res 10:173, 1978 67 Johansson C, Efendic S, Wisén O, Uvnäs-Wallensten K, Luft R Effects of short-time somatostatin infusion on the gastric and in testinal propulsion in humans. Scand J Gastroenterol 13:481-483, 1978 68 Efendic S, Nylén A, Roovete A, Uvnäs-Wallensten K Effects of glucose and arginine on the release of immunoreactive somatostatin from the isolated perfused rat pancreas. FEBS Lett 92:33-35, 1978 69 Tydén G, Samnegård H, Thulin L, Friman L, Efendic S Treatment of bleeding esophageal varices with somatostatin. N Engl J Med 299:1466-1467, 1978 70 Brismar K, Bajraktari X, Goulatia R, Efendic S The empty sella syndrome - intrasellar cisternal herniation - in ”normal” patients and in patients with communicating hydrocephalus and intracranial tumors. Neuroradiology 17:35-43, 1978 71 Efendic S, Mattsson O Effect of somatostatin on intestinal motility. Acta Radiol /Diagn/ (Stockh) 19:348-352, 1978 72 Samnegård H, Thulin L, Andréen M, Tydén G, Hallberg D, Efendic S Circulatory effects of somatostatin in anaesthetized dogs. Acta Chir Scand 145:209-212, 1979 73 Thulin L, Tydén G, Samnegård H, Muhrbeck O, Efendic S Treatment of bleeding oesophageal varices with somatostatin. Acta Chir Scand 145:395-398, 1979 74 Tydén G, Samnegård H, Thulin L, Muhrbeck O, Efendic S Circulatory effects of somatostatin in anaesthetized man. Acta Chir Scand 145:443-446, 1979 75 Efendic S, Cerasi E, Elander I, Thornqvist C, Fick G, Berglund B, Luft R Studies on low insulin responsers. Glucose tolerance and insulin response to intravenous and oral glucose challenges in 226 normal subjects and 25 subjects with mild or chemical diabetes. Acta Endocrinol (Copenh) /Suppl 224/ 90:5-32, 1979 76 Efendic S, Lins PE, Cerasi E Potentiation and inhibition of insulin release in man following priming with glucose and with arginine - effect of somatostatin.

Acta Endocrinol (Copenh) 90:259-271, 1979 77 Cerasi E, Efendic S, Thornqvist C, Luft R Effect of two sulphonylureas on the dose kinetics of glucose-induced insulin release in normal and diabetic subjects. Acta Endocrinol (Copenh) 91:282-293, 1979 78 Uvnäs-Wallensten K, Efendic S, Uvnäs B, Lundberg JM Release of gastrin from the skeletal muscles and from the antral mucosa in cats induced by sulfonuric drugs. Acta Physiol Scand 106:267-270, 1979 79 Efendic S, Mattsson O, Luft R Somatostatin in computer tomography of the abdomen. Acta Radiol /Diagn/ (Stockh) 20:369-371, 1979 80 Lins PE, Efendic S Responses of patients with insulinomas to stimulators and inhibitors of insulin release that have been linked with cyclic adenosine monophosphate. Diabetes 28:190-195, 1979 81 Berglund B, Efendic S, Strandell T, Luft R Capillary permeability in healthy males with different insulin response to glucose. Eur J Clin Invest 9:363-367, 1979 82 Adamson U, Efendic S Insulin-like and diabetogenic effects of growth hormone in healthy subjects, diabetics, and low insulin responders. J Clin Endocrinol Metab 49:456-460, 1979 83 Uvnäs-Wallensten K, Larsson I, Johansson C, Efendic S Phosphate buffer stimulates somatostatin release into the antral lumen of anaesthetized cats. Scand J Gastroenterol 14:797-800, 1979 84 Lundberg JM, Hamberger B, Schultzberg M, Hökfelt T, Granberg P-O, Efendic S, Terenius L, Goldstein M, Luft R Enkephalin- and somatostatin- like immunoreactivities in human adrenal medulla and pheochromocytoma. Proc Natl Acad Sci USA 76:4079-4083, 1979 85 Efendic S, Enzmann F, Nylen A, Uvnäs-Wallensten K, Luft R Effect of glucose/sulfonylurea interaction on release of insulin, glucagon, and somatostatin from isolated perfused rat pancreas. Proc Natl Acad Sci USA 76:5901-5904, 1979 86 Lins PE, Efendic S, Hall K Effect of 24-hour somatostatin infusion on glucose homeostasis and on the levels of somatomedin A and pancreatic and thyroid hormones in man. Acta Med Scand 206, 441-445, 1979 87 Tyden G, Samnegård H, Thulin L, Efendic S Somatostatin and bleeding esophageal varices. N Engl J Med 301(1): 46, 1979

88 Eriksson U, Andersson A, Efendic S, Elde R, Hellerström C Diabetes in pregnancy: effects on the foetal and newborn rat with particular regard to body weight, serum insulin concentration and pancreatic contents of insulin, glucagon, and somatostatin. Acta Endocrinol (Copenh) 94:354-364, 1980 89 Adamson U, Broström L-Å, Efendic S, Hall K Glucose tolerance, growth hormone and somatomedin levels in osteosarcoma patients. Acta Endocrinol (Copenh) 94:517-522, 1980 90 Adamsson U, Efendic S, Granberg P-O, Lindvall N, Lins PE, Löw H Preoperative localization of aldosteron-producing ademonas. An analysis of the efficiency of different diagnostic procedures made from 11 cases and from a review of the literature. Acta Med Scand 208, 101-109, 1980 91 Efendic S, Enzmann F, Nylén A, Uvnäs-Wallensten K, Luft R Sulphonylurea (Glibenclamide) enhances somatostatin and inhibits glucagon release induced by arginine. Acta Physiol Scand 108:231-233, 1980 92 Wisen O, Uvnäs-Wallensten K, Efendic S, Johansson C Release of gastrin and somatostatin into the gastric lumen of healthy subjects and patients with duodenal ulcer and achlorhydria. Acta Physiol Scand 108:297-300, 1980 93 Uvnäs-Wallensten K, Efendic S, Roovete A, Johansson C Decreased release of somatostatin into the portal vein following electrical vagal stimulation in the cat. Acta Physiol Scand 109:393-398, 1980 94 Lins PE, Petersson B, Efendic S Effects of short-term and prolonged infusions of somatostatin on endocrine pancreas, body weight and food intake in rats. Acta Physiol Scand 110:267-275, 1980 95 Uvnäs-Wallensten K, Efendic S, Johansson C, Sjödin L, Cranwell PD Effect of intraluminal pH on the release of somatostatin and gastrin into antral, bulbar and ileal pouches. Acta Physiol Scand 110:391-400, 1980 96 Szecowka J, Sandberg E, Efendic S The interaction of vasoactive intestinal polypeptide (VIP), glucose and arginine on the secretion of insulin, glucagon and somatostatin in the perfused rat pancreas. Diabetologia 19:137-142, 1980 97 Lins PE, Efendic S, Meyers CA, Coy DH, Schally A, Luft R Selective effect of some somatostatin analogs on glucagon as opposed to insulin release in rats in vivo. Metabolism 29:728-731, 1980 98 Szecowka J, Tatemoto K, Mutt V, Efendic S Interaction of newly isolated intestinal polypeptide (PHI) with glucose and arginine to effect the secretion of insulin and glucagon. Life Sci 26:435-438, 1980 98 Efendic S, Wajngot A, Cerasi E, Luft R Insulin release, insulin sensitivity, and glucose intolerance. Proc Natl Acad Sci USA 77:7425-7429, 1980 100 Berglund B, Wajngot A, Freyschuss U, Milentievic, Efendic S Cardovascular reflexes in short-term diabetics with normal physical working capacity. Scand J Clin Lab Invest 40:749-753, 1980

101 Adamson U, Grill V, Efendic S Previous exposure to glucose enhances insulin and suppresses glucagon responses to arginine in man. Acta Diabetol Lat 18:173-179, 1981 102 Efendic S, Enzmann F, Gutniak M, Nylén A, Zoltobrocki M Insulin, glucagon and somatostatin in the perfused rat pancreas and the effects of HB699 [4-(2-(5-chloro-2 metoxy-benzamido)-etyl)-benzoic acid]. Acta Endocrinol (Copenh) 98:573-579, 1981 103 Grill V, Rundfeldt M, Efendic S Previous exposure to glucose enhances somatostatin secretion from the isolated perfused rat pancreas. Diabetologia 20:495-500, 1981 104 Assan R, Efendic S, Luft R, Cerasi E Dose-kinetics of pancreatic glucagon responses to arginine and glucose in subjects with normal and impaired pancreatic beta-cell function. Diabetologia 21:452-459, 1981 105 Johansson C, Kollberg B, Efendic S, Uvnäs-Wallensten K Effects of graded doses of somatostatin on gallbladder emptying and pancreatic enzyme output after oral glucose in man. Digestion 22:24-31, 1981 106 Johansson C, Wisén O, Efendic S, Uvnäs-Wallensten K Effects of somatostatin on gastrointestinal propagation and absorption of oral glucose in man. Digestion 22:126-137, 1981 107 Hanson U, Moberg P, Efendic S Dosage of insulin during delivery and the immediate post-partum period on pregnant diabetics. Acta Ostet Gynecol Scand 60:183-186, 1981 108 Uvnäs-Wallensten K, Efendic S, Johansson C, Sjödin L, Cranwell PD Effect of intraantral and intrabulbar pH on somatostatin-like immunoreactivity in peripheral venous blood of conscious dogs. The possible function of somatostatin as an inhibitory hormone of gastric acid secretion and its possible identity with bulbogastrone and antral chalone. Acta Physiol Scand 111:397-408, 1981 109 Brismar K, Efendic S Pituitary function in the empty sella syndrome. Neuroendocrinology 32:70-77, 1981 110 Szecowka J, Grill V, Sandberg E, Efendic S Effect of GIP on the secretion of insulin and somatostatin and the accumulation of cyclic AMP in vitro in the rat. Acta Endocrinol (Copenh) 99:416-421, 1982 111 Szecowka J, Lins PE, Efendic S Effects of cholecystokinin, gastric inhibitory polypeptide, and secretin on insulin and glucagon secretion in rats. Endocrinology 110:1268-1272, 1982 112 Efendic S, Grill V, Nylen A, Östenson C-G Difference in calcium dependency of insulin, glucagon and somatostatin secretion in response to glibenclamide in perfused rat pancreas. Diabetologia 22:475-479, 1982 113 Adamson U, Efendic S, Lins PE, Wajngot A Effect of somatostatin on insulin induced hypoglycemia in man. Acta Med Scand 212:33-37, 1982

114 Wajngot A, Grill V, Efendic S, Cerasi E The Staub-Traugott effect. Evidence for multifactorial regulation of a physiological function. Scand J Clin Lab Invest 42:307-313, 1982 115 Wajngot A, Roovete A, Vranic M, Luft R, Efendic S Insulin resistance and decreased insulin response to glucose in lean type 2 diabetics. Proc Natl Acad Sci USA 79:4432-4436, 1982 116 Ware J, Ljungqvist O, Norberg KA, Efendic S, Nylander G Glucose, insulin and osmolality changes in rats sustaining different hemorrhage volumes. Acta Phsyiol Scand 116 31-36, 1982 117 Iselius L, Lindsten J, Morton NE, Efendic S, Cerasi E, Haegermark A, Luft R Evidence for an autosomal recessive gene regulating the persistence of the insulin response to glucose in man. Clin Gen 22:180-194, 1982 118 Wajngot A, Luft A, Vranic M, Efendic S Glucose metabolism in the basal state and during a two-hour glucose infusion in low insulin responders and control subjects. Horm Metab Res 14:564-568, 1982 119 Grill V, Efendic S Loss of priming effect of glucose in A and D cell secretion in perfused pancreases from Alloxan-diabetic rats: Role of insulin and Alloxan. Diabetologia 24:47-51, 1983 120 Szecowka J, Lins PE, Tatemoto K, Efendic S Effects of porcine intestinal heptacosapeptide and vasoactive intestinal polypeptide on insulin and glucagon secretion in rats. Endocrinology 112:1469-1473, 1983 121 Szecowka J, Tendler D, Efendic S Effects of PHI on hormonal secretion from perfused rat pancreas. Am J Physiol 245:E313-E317, 1983 122 Szecowka J, Tatemoto K, Rajamäki G, Efendic S Effects of PYY and PP on endocrine pancreas. Acta Physiol Scand 119:123-126, 1983 123 Lins PE, Wajngot A, Adamson U, Vranic M, Efendic S Minimal increases in glucagon levels enhance glucose production in man with partial hypoinsulinemia. Diabetes 32:630-636, 1983 124 Östenson C-G, Grill V, Nylén A, Efendic S Modulation by IBMX, fasting and experimental diabetes of glibenclamide-induced islet hormone release from the perfused rat pancreas. Diabet Metab 9:58-65, 1983 125 Wajngot A, Luft R, Efendic S Oral glucose tolerance test and insulin sensitivity in low insulin responders. Acta Endocrinol 104:77-84, 1983 126 Radosevic-Stasic B, Polic L, Rukavina D, Efendic S Inhibition of local graft-versus-host reaction by somatostatin in mice. IRCS Med Sci 11:1097, 1983 127 Polic L, Radosevic-Stasic B, Rukavina D, Efendic S Humoral immune response of mice and rats treated with somatostatin. Per Biol /Suppl 3/ 85:101-102, 1983

128 Efendic S, Luft R, Wajngot A, Walldius G Intravenous glucose tolerance, insulin response to glucose, peripheral sensitivity to insulin, and serum lipoproteins in post myocardial infarct patients with normal fasting blood glucose. Horm Metab Res 8:406-410, 1984 129 Grill V, Efendic S Abnormal D-cell secretion in alloxan-diabetes: influence by drug and aberrant metabolism. Am J Physiol 246 (Endocrinol Metab 9):E483-E492, 1984 130 Adamson U, Efendic S, Lins PE, Hamberger B, Wajngot A Impaired counter-regulation of hypoglycemia in a group of insulin dependent diabetics with recurrent episodes of severe hypoglycemia. Acta Med Scand 216:215-222, 1984 131 Grill V, Nylén A, Östenson C-G, Efendic S Glibenclamide stimulates and glucose inhibits glucagon release induced by calcium deprivation. Diabetes 33:505-509, 1984 132 Grill V, Gutniak M, Roovete A, Efendic S A stimulating effect of glucose on somatostatin release is impaired in non-insulin- dependent diabetes mellitus.J Clin Endocrinol Metab 59:293-297, 1984 133 Grill V, Efendic S Stimulation by calcium and barium of somatostatin release. Evidence for lower sensitivity of D- vis-a-vis B- and A-cells. Acta Physiol Scand 122:401-407, 1984 134 Iselius L, Carlson L A, Morton NE, Efendic S, Lindsten J, Luft R Genetic and environmental determinants for lipoprotein concentrations in blood. Acta Med Scand 217:161-170, 1985 135 Efendic S, Wajngot A, Vranic M Increased activity of the glucose cycle in the liver; an early feature in type 2 diabetes. Proc Natl Acad Sci USA 82:2965-2969, 1985 136 Grill V, Rundfeldt M, Efendic S Evidence that a ”memory” of glucose metabolism densensitizes β -cell responsiveness in perfused pancreas of the rat. Acta Endocrinol (Copenh) 110:114-119, 1985 137 Algvere P, Efendic S, Luft R, Wajngot A Retinal microangiopathy and pigment epithelial lesions in subjects with normal, borderline, and decreased oral glucose tolerance. Br J Ophtalmol 69:416-419, 1985 138 Khan A, Löw H, Efendic S Effects of fasting and refeeding on the activity of hepatic glucose-6-phosphatase in rats. Acta Physiol Scand 124:591-596, 1985 139 Johansson O, Nordlind K, Efendic S, Liden S The immunohistochemical observation of somatostatin-like and avian pancreatic polypeptide-like immunoreactivity in certain cellular elements of diabetic lipodystrophic skin. Dermatologica 171:233-237, 1985 140 Lins PE, Clausen N, Adamson U, Kollind M, Hamberger B, Efendic S Effect of improved glycemic control by continuous subcutaneous insulin infusion on hormonal responses to insulin-induced hypoglycemia in type 1 diabetics.

Acta Med Scand 218:111-118, 1985 141 Iselius L, Lindsten J, Morton NE, Efendic S, Cerasi E, Haegermark A, Luft R Genetic regulation of the kinetics of glucoxe-induced insulin release in man - Studies in families with diabetic and non-diabetic probands. Clin Genet 27:97-103, 1985 142 Östenson C-G, Efendic S Cysteamine exerts multiple effects on the endocrine cells of the rat pancreas. Biochim Biophys Acta 846:242-247, 1985 143 Gutniak M, Grill V, Efendic S Effect of insulin on fasting and meal-stimulated somatostatin-like immunoreactivity in NIDDM. Evidence for more than one mechanism of action. J Clin Endocrinol Metab 62:77-83, 1986 144 Hagander B, Asp N-G, Efendic S, Nilsson-Ehle P, Lundquist I, Schersten B Reduced glycemic response by beet fibre meal in non-insulin-dependent diabetics and relation to gastrointestinal hormones. Diabetes Research 3:91-96, 1986 145 Gutniak M, Grill V, Efendic S Effect of composition of mixed meals- low versus high-carbohydrate content - on insulin, glucagon, and somatostatin release in healthy humans in patients with NIDDM. Diabetes Care 9:244-249, 1986 146 Fried G, Terenius L, Brodin E, Efendic S, Dockray G, Fahrenkrug J, Goldstein M, Hökfelt T Neuropeptide Y, enkephalin and noradrenaline coexist in sympathetic neurons innervating the bovine spleen - Biochemical and immunohistochemical evidence. Cell and Tissue Research 243:495-508, 1986 147 Clausen N, Lins PE, Adamson U, Hamberger B, Efendic S Counterregulation of insulin-induced hypoglycemia in primary hypothyroidism. Acta Endocrinol 111:516-521, 1986 148 Sandberg E, Ahren B, Tendler D, Carlquist M, Efendic S Potentiation of glucose-induced insulin secretion in the perfused rat pancreas by porcine GIP (gastric inhibitory polypeptide), bovine GIP, and bovine GIP(1-39). Acta Physiol Scand 127:323-326, 1986 149 Karlander S, Roovete A, Vranic M, Efendic S Glucose and fructose 6-phosphate cycle in humans. Am J of Physiol 251:E530-E536, 1986 150 Karlander S, Vranic M, Efendic S Increased glucose turnover and glucose cycling in acromegalic patients with normal glucose tolerance. Diabetologia 29:778-783, 1986 151 Östenson C-G, Nylén A, Grill V, Gutniak M, Efendic S Sufonylurea-induced inhibition of glucagon secretion from the perfused rat pancreas. Evidence for a direct, non-paracrine effect. Diabetologia 29:861-867, 1986 152 Tatemoto K, Efendic S, Mutt V, Makk G, Feistner GJ, Barchas JD Pancreastatin, a novel pancreatic peptide that inhibits insulin secretion. Nature 324:476-478, 1986

153 Grill V, Efendic S, Regitz G Potentiation by previous nutrients of glibenclamide-induced insulin release in man. An effect which is counteracted by meal-induced retardation of drug absorption. Scand J Clin Lab Invest 46:527-532, 1986 154 Lins PE, Adamson U, Clausen N, Hamberger B, Efendic S The role of glucagon, catecholamines and cortisol in counterregulation of insulin- induced hypoglycemia in normal man. Acta Med Scand 220:39-46, 1986 155 Ljungqvist O, Efendic S, Eneroth P, Hamberger B, Nylander G, Ware J Nutritional status and endocrine response to hemorrhage. Canadian J Physiol & Pharmacol 64(9):1185-1188, 1986 156 Joreteg T, Efendic S, Jogestrand T Glucose uptake and binding of digoxin to skeletal muscle. Clin Physiol 6(2):191 196, 1986 157 Polic L, Radosevic-Stasic B, Rukavina D, Efendic S The modulation of immunologic potential of splenocytes in induction of local GVHR by somatostatin. Ann N Y Acad Sci 496:303-306, 1987 158 Vranic M, Efendic S Glucose metabolism in acromegaly. Diabetologia 30(6): 442, 1987 159 Efendic S, Hanson U, Persson B, Wajngot A, Luft R Glucose tolerance, insulin release and insulin sensitivity in normal weight women with previous gestational diabetes mellitus. Diabetes 36:413-419, 1987 160 Rastogi KS, Efendic S, Lickley L, Kovacevic N, Vranic M Elevated somatostatin in pancreatic islets of adrenalectomized dogs. Endocrinology 120:544-548, 1987 161 Gutniak M, Grill V, Wiechel K-L, Efendic S Basal and meal-induced somatostatin-like immunoreactivity in healthy subjects and in IDDM and totally pancreatectomized patients. Effects of acute blood glucose normalization. Diabetes 36:802-807, 1987 162 Hamsten A, Efendic S, Walldius G, Szamosi A, deFaire U Glucose tolerance and insulin release to glucose in non-diabetic young male survivors of myocardial infarction. Am Heart J 113:917-927, 1987 163 Grill V, Efendic S Studies of high- and low insulin responders with the hyperglycemic clamp technique. Metabolism 36:1125-1131, 1987 164 Gutniak M, Karlander S, Efendic S Glyburide decreases insulin requirement, increases β-cell response to mixed meal, and does not affect insulin sensitivity. Effects of short and long-term combined treatment in secondary failure to sulfonylurea. Diabetes Care 10:545-554, 1987 165 Hagander B, Björck I, Asp N-G, Efendic S, Holm J, Nilsson-Ehle P, Lundquist I, Schersten B Rye products in the diabetic diet - Postprandial glucose and hormonal responses in non-insulin-dependent diabetic patients as compared to starch availability in vitro and experiments in rats. Diabetes Res and Clin Pract 3:85-96, 1987

166 Kollind M, Adamson U, Lins PE, Efendic S Diabetogenic action of GH and cortisol in insulin-dependent diabetes mellitus. Aspects on the mechanisms behind the Somogyi phenomenon. Horm Met Res 19:156-159, 1987 167 Khan A, Löw H, Efendic S Effect of thyroid hormones on the activity of hepatic glucose-6-phosphatase in fed and fasted rats. Horm Metab Res 19:613-617, 1987 168 Efendic S, Mutt V, Tatemoto K, Quan C, Chang D, Östenson C-G Pancreastatin and islet hormone release. Proc Natl Acad Sci (USA) 84:7257-7260, 1987 169 Lindgren F, Dahlquist G, Efendic S, Möller E, Persson B, Thalme B, Landin M Glucose-induced insulin response and insulin sensitivity is not related to HLA-type but to puberty in siblings of insulin-dependent diabetic subjects. Diabetologia 30:727-732, 1987 170 Hagander B, Asp N-G, Efendic S, Nilsson-Ehle P, Schersten B Dietary fibre decreases fasting blood glucose levels and plasma LDL concentration in non-insulin-dependent diabetic patients. Am J Clin Nutr 47:852-858, 1988 171 Ahrén B, Lindskog S, Tatemoto K, Efendic S Pancreastatin inhibits insulin secretion and stimulates glucagon secretion in mice. Diabetes 37:281-285, 1988 172 Sandberg E, Ahren B, Tendler D, Efendic S Cholecystokinin (CCK)-33 stimulates insulin secretion from the perfused rat pancreas: Studies on the structure-activity relationship. Pharmacol Toxicol 63:42-45, 1988 173 Efendic S, Karlander S, Vranic M Mild type II diabetes markedly increases glucose cycling in the post-absorptive state and during glucose infusion irrespective of obesity. J Clin Invest 81:1953-1961, 1988 174 Hagander B, Asp N-G, Efendic S, Holm J, Lundquist I, Nilsson-Ehle P, Schersten B Metabolic response to beet-fibre test meals. J Human Nutr and Dietetics 1:239-246, 1988 175 Chen Z-W, Agerberth B, Gell K, Andersson M, Mutt V, Östenson C-G, Efendic S, Barros-Söderling J, Persson B, Jörnvall H Isolation and characterization of porcine diazepam-binding inhibitor. A polypeptide not only of cerebral occurrence but also common in intestinal tissues and with effects on regulation of insulin release. Eur J Biochem 174:239-245, 1988 176 Östenson C-G, Pigon J, Doxey JC, Efendic S Alpha2-adrenoceptor blockade does not enhance glucose-induced insulin release in normal subjects or patients with non-insulin dependent diabetes. J Clin Endocrinol Metab 67:1054-1059, 1988 177 Sandberg E, Ahren B, Tendler D, Efendic S Cholecystokinin-33 potentiates and vasoactive intestinal polypeptide inhibits gastric inhibitor polypeptide - induced insulin secretion in the perfused rat pancreas. Acta Endocrinol 117:545-551, 1988

178 Ravazzola M, Efendic S, Östenson C-G, Tatemoto K, Hutton JC, Orci L Location of pancreastatin immunoreactivity in porcine endocrine cells. Endocrinology 123:227-229, 1988 179 Östenson C-G, Cattaneo AG, Doxey JC, Efendic S Alpha-adrenoceptors and insulin release from pancreatic islets of normal and diabetic rats. Am J Physiol 257:E439-E443, 1989 180 Alvestrand A, Mujagic M, Wajngot A, Efendic S Glucose intolerance in uremic patients: the relative contributions of impaired β-cell function and insulin resistance. Clin Nephrol 31:175-183, 1989 181 Wajngot A, Chandramouli V, Schumann WC, Kumaran K, Efendic S, Landau BR Testing of the assumptions made in estimating the extent of futile cycling. Am J Physiol 256:E668-E675, 1989 182 Östenson C-G, Sandler S, Efendic S Effects of pancreastatin on secretion and biosynthesis of insulin and glucose oxidation of isolated rat pancreatic islets. Pancreas 4:441-446, 1989 183 Gutniak M, Grill V, Roovete A, Efendic S Impaired somatostatin response to orally administered glucose in NIDDM patients entails both somatostatin-28 and -14 and is associated with deranged metabolic control. Acta Endocrinol 121:322-326, 1989 184 Östenson C-G, Efendic S, Holst JJ Pancreastatin-like immunoreactivity and insulin are released in parallel from the perfused porcine pancreas. Endocrinology 124:2986-2990, 1989 185 Karlander S-G, Khan A, Wajngot A, Torring O, Vranic M, Efendic S Glucose turnover in hyperthyroid patients with normal glucose tolerance. J Clin Endocrinol Metab 68:780-786, 1989 186 Khan A, Chandramouli V, Östenson C-G, Ahren B, Schumann WC, Löw H, Landau BR, Efendic S Evidence for the presence of glucose cycling in pancreatic islets of the ob/ob Mouse. J Biol Chem 264:9732-9733, 1989 187 Agerberth B, Söderling-Barros J, Jörnvall H, Chen Z-W, Östenson C-G, Efendic S, Mutt V Isolation and characterization of a 60-residue intestinal peptide structurally related to the pancreatic secretory type of trypsin inhibitor: Influence on insulin secretion. Proc Natl Acad Sci USA 86:8590-8594, 1989 188 Giacca A, Gupta R, Efendic S, Hall K, Skottner A, Lickley L, Vranic M Differential effects of IGF-I and insulin on glucoregulation and fat metabolism in depancreatized dogs. Diabetes 39:340-347, 1990 189 Lindgren F, Dahlquist G, Efendic S, Persson B, Skottner BA Insulin sensitivity and glucose-induced insulin response changes during adolescence. Acta Paediatr Scand 79:431-436, 1990

190 Grill V, Pigon J, Hartling SG, Binder C, Efendic S Effects of dexamethasone on glucose-induced insulin and proinsulin release in low and high insulin responders. Metabolism 39:251-258, 1990 191 Wajngot A, Khan A, Giacca A, Vranic M, Efendic S Dexamethasone increases glucose cycling, but not glucose production in healthy subjects. Am J Physiol 259:E626-E632, 1990 192 Khan A, Chandramouli V, Östenson C-G, Löw H, Landau BR, Efendic S Glucose cycling in islets from normal and diabetic rats. Diabetes 39:456-459, 1990 193 Rastogi KS, Lickley L, Jokay M, Efendic S, Vranic M Paradoxical reduction in pancreatic glucagon with normalization of somatostatin and decrease in insulin in normoglycemic alloxan- diabetic dogs: A putative mechanism of glucagon irresponsiveness to hypoglycemia. Endocrinology 126:1096-1104, 1990 194 Khan A, Chandramouli V, Östenson C-G, Berggren P-O, Löw H, Landau BR, Efendic S Glucose cycling is markedly enhanced in pancreatic islets of obese hyperglycemic mice. Endocrinology 126:2413-2416, 1990 195 Östenson C-G, Efendic S, Grill V Abnormal regulation by glucose of somatostatin secretion in the perfused pancreas of NIDDM rats. Pancreas 5:347-353, 1990 196 Östenson C-G, Ahren B, Karlsson S, Sandberg E, Efendic S Effects of porcine diazepam-binding inhibitor on insulin and glucagon secretion in vitro from the rat endocrine pancreas. Regul Pept 29:143-151, 1990 197 Nilsson I, Svenberg TE, Hellström PM, Theodorsson E, Efendic S, Johansson C Jejunal infusion with isotonic mannitol increases pancreatico-biliary output in man. Eur J Gastroenterol Hepatol 2:155-160, 1990 198 Rudberg Sj, Dahlqvist G, Aperia A, Lindblad BS, Efendic S, Skottner A, Persson B Indications that branched chain amino acids, in addition to glucagon, affect the glomerular filtration rate after a high protein diet in insulin-dependent diabetes. Diabetes Res 16(3):101- 109, 1991 199 Ahren B, Pettersson M, Uvnäs-Moberg K, Gutniak M, Efendic S Effects of cholecystokinin (CCK)-8 and CCK-33, and gastric inhibitory polypeptide (GIP) on basal and meal-stimulated pancreatic hormone secretion in man. Diab Res Clin Prac 13:153-162, 1991 200 Ahren B, Östenson C-G, Mårtensson H, Efendic S Pancreatic release of pancreastatin in the pig. Pancreas 6:324-329, 1991 201 Sten-Linder M, Wilhelmsdotter S, Wedell A, Stern I, Pollare T, Arner P, Efendic S, Luft R, Luthman H Screening for insulin receptor gene DNA polymorphisms associated with glucose intolerance in a Scandinavian population. Diabetologia 34:265-270, 1991 202 Johansson O, Hilliges M, Olsson A, Östenson C-G, Morris M, Efendic S Oxytocin in pancreatic islets - Immunohistochemical localization in normal and non- insulin dependent diabetic rats. Acta Phys Scand 141:143-144, 1991

203 Milin C, Radosevic-Stasic B, Kirigin M, Hinic V, Rukavina D, Berggren P-O, Efendic S Somatostatin promotes accumulation of phospholipids in regenerating liver tissue of rats. Bioscience Reports 11:1-6, 1991 204 Karlander S, Armyr I, Efendic S Metabolic effects and clinical value of beet fiber treatment in NIDDM patients. Diab Res Clin Pract 11:65-72, 1991 205 Johansson O, Hilliges M, Östenson C-G, Sandberg E, Efendic S, Mutt V Immunohistochemical localization of porcine diazepam-binding inhibitor (DBI) to rat endocrine pancreas. Cell Tissue Res 263:395-398, 1991 206 Wajngot A, Chandramouli V, Schumann WC, Efendic S, Landau BR Quantitation of glycogen/glucose-1-P cycling in liver. Metabolism 40:877-881, 1991 207 Chandramouli V, Khan A, Östenson C-G, Berggren P-O, Löw H, Landau BR, Efendic S Quantitation of glucose cycling and the extent of equilibration of glucose-6- phosphate with fructose 6-phosphate in islets from ob/ob mice. Biochem J 278:353-359, 1991 208 Karlander S, Gutniak M, Efendic S Effects of combination therapy with glyburide and insulin on serum-lipid levels in NIDDM patients with secondary sulfonylurea failure. Diabetes Care 14:963-967, 1991 209 Brismar K, Grill V, Efendic S, Hall K The insulin-like growth factor binding protein-1 in low and high insulin responders before and during dexamethasone treatment. Metabolism 40:728-732, 1991 210 Höög A, Sandberg E, Efendic S, Östenson C-G, Grimelius L, Falkmer S Porcine diazepam-binding inhibitor is immunohistochemically co-localized with somatostatin in the D-cells of human and porcine gastrointestinal tract and in pancreatic islet cells Endocrine Pathology 2:161-168, 1991 211 Reinecke M, Höög A, Östenson C-C, Efendic S, Grimelius L, Falkmer S Phylogenetic aspects of pancreastatin- and chromogranin-like immunoreactive cells in the gastro-entero-pancreatic and the adrenal neuro- endocrine system of vertebrates. Gen Comp Endocr 83:167-182, 1991 212 Lindgren FA, Hartling SG, Dahlquist GG, Binder C, Efendic S, Persson BE Glucose - induced insulin response is reduced and proinsulin response increased in healthy siblings of type 1 diabetic patients. Diab Med 8:638-643, 1991 213 Rudberg S, Dahlqvist G, Aperia A, Lindblad BS, Efendic S, Skottner A, Persson B Indications that branced chain amino acids, in addition to glucagon, affect the glomerular filtration rate after a high protein diet in insulin-dependent diabetes. Diab Res 16:101-109, 1991 214 Agerberth B, Östenson C-G, Efendic S, Jörnvall H Pancreatic secretory trypsin inhibitor (PSTI) isolated from pig intestine: Influence on insulin and somatostatin release. FEBS Lett 281:227-230, 1991

215 Sjöholm Å, Funakoshi A, Efendic S, Östenson C-G, Hellerström C Long-term inhibitory effects of pancreastatin and diazepam binding inhibitor on pancreatic β-cell deoxyribonucleic acid replication, polyamine content, and insulin secretion. Endocrinology 128:3277-3282, 1991 216 Östenson C-G, Ahrén B, Johansson O, Karlsson S, Hilliges M, Efendic S Diazepam-binding inhibitor and the endocrine pancreas. Neuropharmacology 30:1391-1398, 1991 217 Kindmark H, Köhler M, Nilsson T, Arkhammar P, Wiechel K-L, Rorsman P, Efendic S Measurements of cytoplasmic free Ca2+ concentration in human pancreatic islets and insulinoma cells. FEBS Lett 291:310-314, 1991 218 Sten-Linder M, Olsson M, Iselius L, Efendic S, Luthman H DNA haplotype analysis suggests linkage disequilibrium in the human insulin receptor gene. Hum Genet 87:469-474, 1991 219 Fuxe K, Östenson C-G, Aguirre JA, Efendic S, Agerberth B, Mutt V Reserpine treatment increases PEC-60-like immunoreactivity in the substantia nigra of the male rat as determined by radioimmunoassay. Acta Physiol Scand 143:357-358, 1991 220 Muhvic D, Radosevic-Stasic B, Pugel E, Rukavina D, Sepcic J, Efendic S Modulation of experimental allergic encephalomyelitis by somatostatin. Ann N Y Acad Sci 650:170-178, 1992 221 Grill V, Alvarsson M, Efendic S Dexamethasone treatment fails to increase arginine-induced insulin release in healthy subjects with low insulin response. Diabetologia 35:367-371, 1992 222 Ahren B, Östenson C-G, Efendic S The intestinal peptide, PEC-60, inhibits insulin secretion in the mouse and the rat. Pancreas 7:443-446, 1992 223 Wahlberg G, Walldius G, Efendic S Effects of nicotinic acid on glucose tolerance and glucose uptake into adipose tissue. Scand J Clin Invest 52:537-545, 1992 224 Wajngot A, Giacca A, Grill V, Vranic M, Efendic S The diabetogenic effects of glucocorticoids are more pronounced in low than in high insulin responders (prediabetes/increased risk of developing NIDDM). PNAS 89:6035-6039, 1992 225 Gutniak M, Orskov C, Holst JJ, Ahren B, Efendic S Antidiabetogenic effect of glucagon like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus. New Engl J Med 326:1316-1322, 1992 226 Kindmark, H, Köhler M, Efendic S, Rorsman P, Larsson O, Berggren P-O Protein kinase C activity affects glucose-induced oscillations in cytoplasmic free Ca2+ in the pancreatic β-cell. FEBS Lett 303:85-90, 1992 227 Alvarsson M, Grill V, Wajngot A, Cerasi E, Efendic S Long-term stability of low insulin responses to glucose in non- diabetic subjects. Acta Endocrinol 127:33-37, 1992

228 Persson B, Slezak P, Efendic S, Hggmark A Can somatostatin prevent injection pancreatis after ERCP? Hepato-Gastroenterol 39:259-261, 1992 229 Khan A, Östenson C-G, Berggren P-O, Efendic S Glucocorticoid increases glucose cycling and inhibits insulin release in pancreatic islets of ob/ob mice. Am J Physiol 263:E663-E666, 1992 230 Metsis M, Cintra A, Solfrini V, Ernfors P, Bortolotti F, Morrasutti DG, Östenson C-G, Efendic S, Agerberth B, Mutt V, Persson H, Fuxe K Molecular cloning of PEC-60 and expression of its mRNA and peptide in the gastrointestinal tract and immune system. J of Biological Chem 267:19829-19832, 1992 231 Rastogi KS, Brubaker PL, Kawasaki A, Efendic S, Vranic M Increase in somatostatin to glucagon ratio in islets of alloxan diabetic dogs: Effect of insulin-induced euglycemia. Can J Physiol Pharmacol 71:512-517, 1993 232 Östenson C-G, Khan A, Abdel-Halim SM, Guenifi A, Suzuki K, Goto Y, Efendic S Abnormal insulin secretion and glucose metabolism in pancreatic islets from the spontaneously diabetic GK rat. Diabetologia 36:3-8, 1993 233 Sten-Linder M, Wedell A, Iselius L, Efendic S, Luft R, Luthman H DNA polymorphisms in the human tyrosine hydroxylase/insulin/insulin-like growth factor II chromosomal region in relation to glucose and insulin responses. Diabetologia 36:25-32, 1993 234 Persson B, Pschera H, Binder C, Efendic S, Hanson U, Hartling S, Lunell NO Decreased beta-cell function in women with previous small for gestational age infants. Horm metab Res 25:170-174, 1993 235 Båvenholm P, Malmberg K, Efendic S, Wiman B, deFaire U, Hamsten A Hyperinsulinaemia, hypertriglyceridaemia and impaired fibrinolytic function: concordant abnormalities associated with myocardial infarction at young age. Nutr Metab Cardiovasc Dis 3:28-37, 1993 236 Östenson C-G, Hjemdahl P, Efendic S Release of catecholamines increased but does not contribute to the impaired insulin secretion in the perfused pancreata of diabetic rats. Pancreas 8:34-38, 1993 237 Östenson C-G, Abdel-Halim S, Rasschaert J, Malaisse-Lagae, Meuris S, Sener A, Efendic S, Malaisse WJ Deficient activity of FAD-linked glycerophosphate dehydrogenase in islets of GK- rats. Diabetologia 36:722-726, 1993 238 Thorell A, Efendic S, Gutniak M, Hggmark T, Ljungqvist O Development of postoperative insulin resistance is associated with the magnitude of operation. Eur J Surg 159:593-599, 1993 239 Abdel-Halim SM, Guenifi A, Efendic S, Östenson C-G Both somatostatin and insulin responses to glucose are impaired in the perfused pancreas of the spontaneously non-insulin-dependent diabetic GK (Goto-Kakizaki) rats. Acta Physiol Scand 148:219-226, 1993

240 Giacca A, Fisher SJ, Shi ZQ, Gupta R, Lickley HL, Skottner A, Anderson GH, Efendic S, Vranic M Insulin-like growth factor-I and insulin have no differential effects on glucose production and utilization under conditions of hyperglycemia. Endocrinology 134(5):2251-2258, 1994 241 Fuxe K, Tinner B, Metsis M, Staines W, Morassutti D, Agnati LF, Östenson CG, Efendic S, Agerberth B, Goldstein M Generalized presence of a PEC-60-like peptide in catecholamine neurones. Neuroreport 5(14):1817-1821, 1994 242 Abdel-Halim SM, Guenifi A, Luthman H, Grill V, Efendic S, Östenson C-G Impact of diabetic inheritance on glucose tolerance and insulin secretion in spontaneously diabetic GK rats. Diabetes 43:281-288, 1994 243 Thorell A, Efendic S, Gutniak M, Häggmark T, Ljungqvist O Insulin resistance after abdominal surgery. Br J Surg 81:59-63, 1994 244 Ljungqvist O, Thorell A, Gutniak M, Häggmark T, Efendic S Glucose infusion instead of preoperative fasting reduces postoperative insulin resistance. J Am Coll Surg 178:329-336, 1994 245 Lemne C, Efendic S, Hamsten A, de Faire U Impaired glucose and insulin metabolism in borderline hypertension. Blood pressure 3:287-294, 1994 246 Efendic S, Khan A, Östenson, C-G Insulin release in type 2 diabetes mellitus. Diabete & Metabolisme (Paris) 20:84-86, 1994 247 Chen ZW, Bergman T, Östenson C-G, Höög A, Näslund J, Norberg Å, Carlquist M, Efendic S, Mutt V, Jörnvall H A porcine gut polypeptide identical to the pancreatic hormone PP (pancreatic polypeptide). Febs Lett 341:239-243, 1994 248 Östenson C-G, Ahren B, Karlsson S, Knudsen J, Efendic S Inhibition by rat diazepam-binding inhibitor/acyl-CoA-binding protein of glucose- induced insulin secretion in the rat. Eur J Endocrinol 131:201-204, 1994 249 Svensson AM, Abdel-Halim SM, Efendic S, Jansson L, Östenson C-G Pancreatic and islet blood flow in F1-hybrids of the non-insulin dependent diabetic GK-wistar rat. Eur J Endocrinol 130:612-616, 1994 250 Malmberg K, Efendic S, Ryden L Feasibility of insulin-glucose infusion in diabetic patients with acute myocardial infarction. A report from the multicenter trial: DIAGMI. Diabetes Care 17:1007-1014, 1994 251 Gutniak M, Linde B, Holst JJ, Efendic S Subcutaneous injection of the incretin hormone glucagon-like peptide-1 abolishes postprandial glycaemia in non-insulin-dependent diabetes. Diabetes Care 17:1039-1044, 1994 252 Svensson AM, Östenson C-G, Sandler S, Efendic S, Jansson L Inhibition of nitric oxide synthase by NG-nitro-L-arginine causes a preferential decrease in pancreatic islet blood flow in normal rats and spontaneously diabetic GK rats. Endocrinology 135:849-853, 1994

253 Kindmark H, Köhler M, Arkhammar P, Efendic S, Larsson O, Linder S, Nilsson T, Berggren P-O Oscillations in cytoplasmic free calcium concentration in human pancreatic islets from subjects with normal and impaired glucose tolerance. Diabetologia 37:1121-1131, 1994 254 Wajngot A, Alvarsson M, Glaser A, Efendic S, Luthman H, Grill V Glucose potentiation of arginine-induced insulin secretion is impaired in subjects with a glucokinase Glu256Lys mutation. Diabetes 43:1402-1406, 1994 255 Alvarsson M, Efendic S, Grill V Insulin responses to glucose in healthy males are associated with adult hight but not with birth weight. J of Internal Med 236:275-279, 1994 256 Alvarsson M, Wajngot A, Efendic S, Grill V Relationship between insulin responses to D-glucose and to L-arginine in women with a history of gestational diabetes. Acta Diabetologica 32:86-91, 1995 257 Malmberg K, Ryden L, Efendic S, Herlitz J, Nicol P, Waldenström A, Wedel H, Welin L Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI Study): Effects on mortality at 1 year. JACC 26:57-65, 1995 258 Pigon J, Efendic S, Östenson C-G, Lam L, Vranic M, Giacca A Insulin-stimulated glucose uptake is enhanced in sedentary and endurance-trained low insulin responders. Am J Physiol 268:E1046-E1050, 1995 259 Abdel-Halim SM, Östenson C-G, Andersson A, Jansson L, Efendic S A defective stimulus-secretion coupling rather than glucotoxicity mediates the impaired insulin secretion in the mildly diabetic F1 hybrids of GK-Wistar rats. Diabetes 44:1280-1284, 1995 260 Zaitsev SV, Efendic S, Arkhammar P, Bertorello AM, Berggren P-O Dissociation between changes in cytoplasmic free Ca2+ concentration and insulin secretion as evidenced from measurements in mouse single pancreatic islets. Proc Natl Acad Sci USA 92:9712-9716, 1995 261 Khan A, Efendic S Evidence that increased glucose cycling in islets of diabetic ob/ob mice is a primary feature of the disease. Am J Physiol 269:E1-E4,1995 262 Jansson L, Efendic S Pancreatic polypeptide and splanchnic blood flow in anesthetized rats. Peptides 16:1253-1256, 1995 263 Nygren J, Sammann M, Malm M, Efendic S, Hall K, Brismar K, Ljungqvist O Disturbed anabolic hormonal patterns in burned patients: the relation to glucagon. Clin Endocrinol 43:491-500, 1995 264 MacDonald MJ, Efendic S, Östenson C-G Normalization by insulin treatment of low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of the GK rat. Diabetes 45(7):886-890, 1996

265 Fisher SJ, Shi ZQ, Lavina H, Lickley A, Efendic S, Vranic M, Giacca A A moderate decline in specific activity does not lead to an underestimation of glucose production during a glucose clamp. Metabolism 45:587-593, 1996 266 Clauson P, Karlander S, Steen L, Efendic S Day-time glibenclamide and bedtime NPH insulin compared to intensive insulin treatment in secondary sulfonylurea failure: a one year follow up. Diabetic Medicine 13:471-477, 1996 267 Höög A, Sandberg-Nordqvist AC, Abdel-Halim S, Carlsson-Skwirut C, Guenifi A, Tally M, Östenson C-G, Falkmer S, Sara VR, Efendic S, Schalling M, Grimelius L Increased amounts of a high-molecular-weight insulin-like growth factor II (IGF-II)- peptide and IGF-II messenger ribronucleic acid in pancreatic islets of diabetic Goto- Kakizaki (GK) rat. Endocrinology 137:2415-2423, 1996 268 Shi ZQ, Rastogi KS, Lekas M, Efendic S, Drucker DJ, Vranic M Glucagon response to hypoglycemia is improved by insulin-dependent restoration of normoglycemia in diabetic rats. Endocrinology 137:3193-3199, 1996 269 Gutniak M, Juntti-Berggren L, Hellström PM, Guenifi A, Holst JJ, Efendic S GLP-I (Glucagon-like-peptide) enhances the insulinotropic effect of glibenclamide in NIDDM patients and in the perfused rat pancreas. Diabetes Care 19(8):857-863, 1996 270 Abdel-Halim S, Guenifi A, Khan A, Larsson O, Berggren P-O, Östenson C-G, Efendic S Impaired coupling of glucose signal to the exocytotic machinery in diabetic GK rats. A defect ameliorted by cAMP. Diabetes 45:934-940, 1996 271 MacDonald MJ, Efendic S, Östenson C-G Normalization by insulin treatment of low mitocondrial glycerol phosphate dedydrogenase and pyruvate carboxylase in pancreatic islets of the GK rat. Diabetes 45:886-890, 1996 272 Berggren-Juntti L, Pigon J, Karpe F, Hamsten A, Gutniak M, Vignati L, Efendic S The antidiabetiogenic effect of GLP-I is maintained during a 7-day treatment period and improves diabetic dyslipoproteinemia in NIDDM patients. Diabetes Care 19(11):1200-1206, 1996 273 Pigon J, Giacca A, Östenson C-G, Lam L, Vranic M, Efendic S Normal hepatic insulin sensitivity in lean, mild noninsulin-dependent diabetic patients. J Clin Endocrinol Metab 81(10):3702-3708, 1996 274 Leckström A, Östenson C-G, Efendic S, Arnelo U, Permert J, Lundquist L, Westermark P Increased storage and secretion of islet amyloid polypeptide relative to insulin in the spontaneously diabetic GK rat. Pancreas 13: 259-267, 1996 275 Zaitsev SV, Efanov AM, Efanova IB, Larsson O, Östenson C-G, Gold G, Berggren P-O, Efendic S Imidazoline compounds stimulate insulin release by inhibition of KATP channels and interaction with the exocytotic machinery. Diabetes 45(11):1610-1618, 1996

276 Nyren S, Blomqvist L, Efendic S, Grill V Pancreas size and insulin secretion: lack of association in non-diabetic subjects. Acta Diabetol 33:274-276, 1996 277 Steiner G for the DAIS Project Group - Stockholm, S Efendic (Director). The diabetes atherosclerosis intervention study (DAIS): a study conducted in cooperation with the world health organization. Diabetologia 39:1655-1661, 1996 278 Carlsson P-O, Östenson C-G, Efendic S, Langel U, Jansson L Pituitary adenylate cyclase activiating polypeptide (PACAP) redistributes the blood within the pancreas of anesthetized rats by acting on the VIP receptor. Regul Peptides 63:123-128, 1996 279 Brubaker PL, Efendic S, Greenberg GR Truncated and full-length glucagon-like peptide-1 (GLP-1) differentially stimulate intestinal somatostatin release. Endocrinology 6(1):91-95, 1997 280 Östenson C-G, Zaitsev S, Efendic S Galparan, a powerful insulin releasing chimeric peptide acting at a novel site. Endocrinology 138(8):3308-3313, 1997 281 Chen Z-W, Bergman T, Jörnvall H, Bonetto V, Norberg Å, Mutt V, Longone P, Costa E, Efendic S, Östenson C-G Full-lenght and N-terminally truncated chicken intestinal diazepam-binding inhibitor: purification, structural characterization and influence on insulin release. Regulatory Peptides 69:63-68, 1997 282 Nygren J, Thorell A, Efendic S, Nair S, Ljungqvist O Site of insulin resistance after surgery: the contribution of hypocaloric nutrition and bed rest. Clinical Science 93:137-146, 1997 283 Zaitsev S, Efanova I, Östenson C-G, Efendic S, Berggren P-O Delayed Ca2+response to glucose in diabetic GK rat. Biochem & Biophys Res Comm 239:129-133, 1997 284 Delaunay F, Khan A, Cintra A, Davani B, Zong-Chao L, Andersson A, Östenson C-G, Gustafsson J-Å, Efendic S, Okret S Pancreatic B-cells are important targets for the diabetogenic effects of glucocorticoids. J of Clin Invest 100:2094-2098, 1997 285 Krook A, Kawano Y, Song XM, Efendic S, Roth RA, Wallberg-Henriksson H, Zierath JR Improved glucose tolerance restores insulin-stimulated Akt kinase activity and glucose transport in skeletal muscle from diabetic Goto-Kakizaki (GK) rats. Diabetes 46:2110-2114, 1997 286 Chen Z-W, Ahren B, Östenson C-G, Cintra A, Bergman T, Möller C, Fuxe K, Mutt V, Jörnvall H, Efendic S Identification, isolation and characterization of daintain (allograft inflammatory factor-), a macrophage polypeptide with effects on insulin secretion and abundantly present in the pancreas of prediabetic BB rats. PNAS 94(25):13879-13884, 1997 287 Svensson AM, Efendic S, Östenson C-G, Jansson L Gastric inhibitory polypeptide and splanchnic blood perfusion: augmentation in the islet blood flow increase in hyperglycemic rats. Peptides 18:1055-1059, 1997

288 Chen ZW, Bergman T, Östenson C-G, Efendic S, Mutt V, Jörnvall H Characterization of dopain, a polypeptide with special residue distributions. Europ J B 249:518-522, 1997 289 Östenson C-G, Abdel-Halim SM, Guenifi A, Efendic S Aspects of impaired β-cell function in NIDDM; studies in the spontaneously diabetic GK rats. Exp Clin Endocrinol Diabetes 105 (Suppl 3):S91, 1997 290 Abdel-Halim SM, Bakhiet M, He B, Guenifi A, Mustafa M, Höjeberg B, Hillert J, Efendic S Mutations in the promoter region of type III adenylyl cyclase (AC-III) gene underlie an enhanced AC-III mRNA expression and cAMP genereation in islets from the spontaneously diabetic GK rat model of NIDDM. Diabetes 47:498-504, 1998 291 Efanova IB, Zaitsev SV, Brown G, Berggren P-O, Efendic S RX871024 induces Ca2+ mobilization from thapsigargin-sensitive stores in mouse pancreatic β-cells. Diabetes 47:211-218, 1998 292 Båvenholm P, de Faire U, Landau C, Efendic S, Nilsson J, Wiman B, Hamsten A Progression of coronary artery disease in young male post-infarction patients is linked to disturbances of carbohydrate and lipoprotein metabolism and to impaired fibrinolytic function. Eur Heart J 19:402-410, 1998 293 Efanov AM, Zaitsev SV, Efanova IB, Östenson C-G, Berggren P-O, Efendic S Signalling and sites of interaction for RX-871024 and sulfonylurea in the stimulation of insulin release. Am J Phys 274:E751-E757, 1998 294 Khan A, Ling Z-C, Efendic S, Landau BR Glucose-6-phosphatase like activity in the hypothalamus of the ob/ob mouse. Metabolism 47:627-629, 1998 295 Bränström R, Efendic S, Berggren P-O, Larsson O Direct inhibition of the pancreatic β-cell ATP-regulated potassium channel by α- ketoisocaproate. J Biolog Chem 273(23): 14113-14118, 1998 296 Ling Z-C, Efendic S, Wibom R, Östenson C-G, Landau BR, Khan A Glucose metabolism in the GK rat islets. Endocrinology 139:2670-2675, 1998 297 Ling Z-C, Khan A, Delauney F, Davani B, Östenson C-G, Gustafsson J-Å, Okret S, Landau BR, Efendic S Increased glucocorticoid sensitivity in islet á-cells: Effects of glucose-6- phosphatase, glucose cycling and insulin release. Diabetologia 41:634-639, 1998 298 Khan A, Ling Z-C, Pukk K, Herling AW, Landau BR, Efendic S Effect of 3-mercatopicolinic acid and a derivative of cholorgenic acid (S-3483) on hepatic and islet glucose-6-phosphatase activity. Eur J Pharmacol 349:325-331, 1998 299 Nygren JO, Thorell A, Soop M, Efendic S, Brismar K, Karpe F, Nair KS, Ljungqvist O Perioperative insulin and glucose infusion maintains normal insulin sensitivity after surgery. Am J Physiol 275:E140-E148, 1998

300 Carlsson S, Persson P-G, Grill V, Alvarsson M, Efendic S, Norman A, Svanström L, Östenson C-G Weight history, glucose tolerance and insulin levels in middle-aged Swedish men. Am J of Epidemiology 148(6):539-545, 1998 301 Tolessa T, Gutniak M, Holst JJ, Efendic S, Hellström PM Inhibitory effect of glucagon-like peptide-1 on small bowel motility. Fasting but not fed Motility inhibited via Nitric oxide independently of insulin and somatostatin. J Clin Invest 102(4):764-774, 1998 302 Tolessa T, Gutniak M, Holst JJ, Efendic S, Hellström PM Glucagon-like peptide-1retards gastric emptying in small bowel transit in the rat. Effect mediated through central or enteric nervous mechanisms. Digestive Diseases & Sciences 43(10): 2284-2290, 1998 303 Guenifi A, Abdel-Halim SM, Efendic S, Östenson C-G Preserved initiatory and potentiatory effect of α-ketoisocaproate on insulin release in islets of glucose intolerant rats. Diabetologia 41:1368-1373, 1998 304 Efanova IB, Zaitsev SV, Zhivotovsky B, Köhler M, Efendic S, Orrenius S, Berggren P-O. Glucose and tolbutamide induce apoptosis in pancreatic β-cells. J of Biol Chem 273(50): 33501-33507, 1998 305 Efanova IB, Zaitsev SV, Efanov AM, Östenson C-G, Raap A, Mest H-J, Berggren P-O, Efendic S

Effects of imidazoline derivative RX8871024 on insulin, glucagon, and somatostatin secretion from isolated perfused rat pancreas. Biochem Biophys Res Comm 252:162-165, 1998

306 Zaitsev SV, Andersson M, Efanov AM, Efanova IB, Östenson C-G, Juntti- Berggren L, Berggren P-O, Mutt V, Efendic S An endogenous peptide isolated from the gut, NK-lysin, stimulates insulin secretion without changes in cytosolic free Ca2+ concentration. FEBS Lett 439: 267-270, 1998 307 Nygren J, Soop M, Thorell A, Efendic S, Nair KS, Ljungqvist O

Preoperative oral carbohydrate administration reduces postoperative insulin resistance. Clinical Nutrition 17:65-71, 1998

308 Grill V, Persson G, Carlsson S, Norman A, Alvarsson M, Östenson C-G, Svanström L, Efendic S Family history of diabetes middle-aged Swedish men is a gender unrelated factor which associates with insulinopenia in newly diagnosed diabetic subjects. Diabetologia 42: 15-23, 1999 309 Song, X M, Kawano Y, Krook A, Ryder JW, Efendic S, Roth RA, Wallberg- Henriksson H, Zierath JR Muscle fiber type – specific defects in insulin signal transduction to glucose transport in diabetic GK rats. Diabetes 48: 664-670, 1999 310 Ekberg K, Landau BR, Wajngot A, Chandramouli V, Efendic S, Brunengraber H, Wahren J Contributions by kidney and liver to glucose production in the postabsorptive state and after 60 h fasting. Diabetes 48:292-298, 1999

311 Sandhu H, Wisenthal SR, MacDonald PE, McCall RH, Tchipashvili V, Rashid S, Satkunarajah M, Irwin DM, Shi ZQ, Brubaker PL, Wheeler MB, Vranic M, Efendic S, Giacca A Glucagon-like peptide 1 increases insulin sensitivity in depancreatized dogs. Diabetes 48:1045-1053, 1999 312 Hassan M, Eskilsson A, Nilsson C, Jonsson C, Jacobsson H, Refai E, Larsson S, Efendic S In vivo dynamic distribution of131I-glucagon-like peptide-1 (7-36)amide in the rat studied by gamma camera. Nuclear Med & Biol 26:413-420, 1999 313 Carlsson S, Persson P-G, Alvarsson M, Efendic S, Norman A, Svanström L, Östenson C-G, Grill V

Low birth weight, family history of diabetes, and glucose intolerance in swedish middle-aged men. Diabetes Care 22:1043-1047, 1999

314 Zaitsev SV, Efanov AM, Raap A, Efanova IB, Schloss J, Steckel-Hamann B, Larsson O, Östenson C-G, Berggren P-O, Mest H-J, Efendic S

Different modes of action of the imidazoline compound RX871024 in pancreatic β-cells. Blocking of K+ channels, mobilization of Ca2+ from endoplasmic reticulum, and interaction with exocytotic machinery. Imidazoline Receptors and their endogenous ligands, Ann of NY Acad Sci, 881: 241-252, 1999

315 Hällbrink M, Saar K, Östenson C-G, Soomets U, Efendic S, Howl J, Wheatley M, Zorko M, Langel U

Effects of vasopressin-mastoparan chimeric peptides on insulin release and G-protein activity. Reg Pep 82:45-51, 1999

316 Steiner G, Stewart D, Hosking JD, DAIS Project Group (see appendix)

Baseline characteristics of the study population in the diabetes atherosclerosis intervention study (DAIS). Am J Card 84:1004-1010, 1999

317 Salehi A, Henningsson R, Mosen H, Östenson C-G, Efendic S, Lundquist I Dysfunction of the islet lysosomal system conveys impairment of glucose-induced insulin release in the diabetic GK rat. Endocrinology 140:3045-3053, 1999

318 Yang, B. He B, Abdel-Halim S, Tibell, Brendel MD, Bretzel RG, Efendic S, Hillert J Molecular cloning of a full-length cDNA for human type 3 adenylyl cyclase and ist expression in human islets. Biochem Biophys Res Comm 254:548-551, 1999 319 Juntti-Berggren L, Pigon J, Hellström P, Holst JJ, Efendic S Influence of acarbose on post-prandial insulin requirements in patients with type 1 Diabetes. Diab Nutr Metab 13:7-12, 2000 320 Sjöholm Å, Sandberg E, Östenson C-G, Efendic S Regulation of in vitro maturation of stimulus-secretion coupling in fetal rat islet β- cells. Endocrine 12:273-278, 2000 321 Guenifi A, Portela-Gomes GM, Grimelius L, Efendic S, Abdel-Halim SM Adenyl cyclase isoforms expression in nondiabetic and diabetic GK (Goto-Kakizaki) rat pancreas. Evidence for distinct overexpression of type-8 adenyl cyclae in diabetic GK rat islets. Histochem Cell Biol 113:81-89, 2000

322 Sjöholm Å, Sandberg E, Östenson C-G, Efendic S Peptidergic regulation of maturation of the stimulus-secretion coupling in fetal islet β-cells.

Pancreas 20:282-289, 2000 323 Ruotulo G, Båvenholm P, Brismar K, Efendic S, Ericsson C-G, deFaire U, Nilsson J, Hamsten A

Serum inulin-like growth factor-I level is independently associated with coronary artery disease progression in young male survivors of myocardial infarction: beneficial effects of bezafibrate treatment. J Am College Cardiology 35:647-654, 2000

324 Ahrén B, Holst JJ, Efendic S

Antidiabetogenic action of cholecystokinin-8 in type 2 diabetes. J Clin Endocrin 85:1043-1048, 2000 325 Båvenholm PN, Pigon J, Saha AK, Ruderman NB, Efendic S

Fatty acid oxidation and the regulation of malonyl COA in human muscle. Diabetes 49:1078-1083, 2000

326 Davani B, Khan A, Hult M, Mårtensson E, Okret S, Efendic S, Jörnvall H, Opperman UCT Type 1 11β-hydroxysteroiddehydrogenase mediates glucocorticoid activation and insulin release in pancreatic islets. J Biol Chem, 275:34841-34844, 2000 327 Carlsson S, Hammar N, Efendic S, Persson P-G, Östenson C-G, Grill V Alcohol consumption, type 2 diabetes mellitus and impaired glucose tolerance In middle-aged Swedish men. Diabetic Med 17:776-781, 2000 328 Wajngot A, Chandramouli V, Schumann WC, Brunengraber H, Efendic S, Landau B A probing dose of phenylacetate does not affect glucose production and gluconeogenesis in humans. Metabolism 49 (9):1211-1214, 2000 329 Pashenkov M, Efendic S, Zhu J, Zou LP, Östenson C-G, Mustafa M Augmented expression of daintain/allograft inflammatory factor-1 is associated with clinical disease: dynamics of daintain/allograft inflammatory factor-1 expression in spleen, peripheral nerves and sera during experimental autoimmune neuritis. Scand J Immunol 52:117-122, 2000 330 Persson P-G, Carlsson S, Grill V, Svanström L, Östenson C-G, Efendic S Cigarette smoking, oral moist snuff use and glucose intolerance. J Intern Med 248:103-110, 2000 331 Wajngot A, Chandramouli V, Schumann, Ekberg K, Jones PK, Efendic S, Landau B Quantitative contributions of gluconeogenesis of glucose production during fasting in type 2 diabetes mellitus. Metabolism 50 (1):47-52, 2001 332 Bonetto V, Eriste E, Jonsson AP, Efendic S, Jörnvall H, Sillard R Isolation of peptides from porcine intestinal tissue that induce extracellular acidification in CHO cells: Identification of the active peptide as IGF-I and characterization of a fragment of calponin H1 processed at a dibasic site. Arch of Biochem and Biophys 385 (2):276-282, 2001 333 Fisher SJ, Shi ZQ, Lickley HL, Efendic S, Vranic M, Giacca A Low-dose IGF-I has no selective advantage over insulin in regulating glucose

metabolism in hyperglycemic depancreatized dogs. J Endocrinology 168:49-58, 2001 334 Chen Z-W, Eriste E, Jonsson AP, Norberg Å, Nepomuceno D, Lovenberg TW, Bergman T, Efendic S, Jörnvall H, Sillard R Ser13 –phosphorylated PYY from porcine intestine with a potent biological activity. FEBS Letters 492:119-122, 2001 335 Ling Z-C, Hong-Lie C, Östenson C-G, Efendic S, Khan A Hyperglycemai contributes to impaired insulin response in GK rat islets. Diabetes 50 (Suppl 1):108-112, 2001 336 Zaitsev SV, Appelskog IB, Kapelioukh IL, Yang S-N, Köhler M, Efendic S, Berggren P-O Imidazoline compounds protect against interleukin 1β-induced β-cell apoptosis. Diabetes 50 (Suppl 1):70-76, 2001 337 Nesher R, Warwar N, Khan A, Efendic S, Cerasi E, Kaiser N Defective stimulus-secretion coupling in islets of psammomys obesus, an animal model for type 2 diabetes. Diabetes 50:308-314, 2001 338 Båvenholm PN, Pigon J, Östenson C-G, Efendic S

Insulin sensitivity of suppression of endogenous glucose production is the single most important determinant of glucose tolerance. Diabetes 50:1449-1454, 2001

339 Efanov AM, Zaitsev SV, Berggren P-O, Hans-Juergen Mest, Efendic S Imidazoline RX 871024 raises diacylglycerol levels in rat pancreatic islets. Biochem Biophys Res Comm 281:1070-1073, 2001 340 Efanov AM, Zaitsev SV, Mest H-J, Raap A, Appelskog IB, Larsson O, Berggren P-O, Efendic S The novel imidazoline compound BL 11282 potentiates glucose-induced insulin Secretion in pancreatic β-cell, in the absence of modulation of K+ -ATP channel activity. Diabetes 50(4):797-802, 2001 341 Kindmark H, Pigon J, Efendic S Glucose-dependent insulinotropic Hormone poatentiates the hypoglycaemic effect of Glibenclamide in healthy volunteers: Evidence for an effect on insulin extraction. J Clin Endocrinol & Metabolism 86(5):2015-2019, 2001 342 Gogg S, Chen J, Efendic S, Smith U, Östenson C-G Effects of phosphotyrosine phosphatase inhibition on insulin secretion and intracellular signaling events in rat pancreatic islets. Biochem & Biophys Res Comm 280:1161-1168, 2001 343 Khan A, Narangoda S, Ahrén B, Holm C, Sundler S, Efendic S Long-term leptin treatment of ob/ob mice improves glucose-induced insulin secretion. Int J Obesity 25:816-821, 2001 344 Hällbrink M, Holmqvist T, Olsson M, Östenson C-G, Efendic S, Langel U Different domains in the third intracellular loop of the GLP-1 receptor are responsible for Gas and Gai/Gao activation. Biochim Biophys Acta 1546:79-86, 2001 345 Ljungqvist O, Nygren J, Thorell A, Brodin U, Efendic S Preoperative nutrition – elective surgery in the fed or the overnight fasted state. Clinical Nutrition 20(Suppl 1):167-171, 2001

346 Steiner G. et al. Effect of fenofibrate on progression of coronary-artery disease in type 2 diabetes: the Diabetes Atherosclerosis Intervention Study, a randomised study. Lancet 357:905-910, 2001 347 Efanov AM, Hoy M, Bränström R, Zaitsev SV, Magnuson MA, Efendic S, Gromada J, Berggren P-O The imidazoline RX871024 stimulates insulin secretion in pancreatic β-cells from mice deficient in KATP channel function. Biochem Biophys Res Commun 284:918-922, 2001 348 Musi N, Hirshman MF, Nygren J, Svanfeldt M, Båvenholm P, Rooyackers O, Zhou G, Williamson JM, Ljungqvist O, Efendic S, Möller DE, Thorell A, Goodyear LJ Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes. Diabetes 51(7): 2074-2081, 2002 349 Efanov AM, Appelskog IB, Abdel-Halim SM, Khan A, Brännström R, Larsson O, Östenson C-G, Mest H-J, Berggren P-O, Efendic S, Zaitsev SV Insulinotropic activity of the imidazoline derivative RX871024 in diabetic GK rat. Am J of Physiol Metab 282:E117-E124, 2002 350 Östenson C-G, Sandberg-Nordqvist A-C, Chen J, Hällbrink M, Rotin D, Langel Û, Efendic S Overexpression of protein-tyrosine phosphatase PTPσ is linked to impaired glucose-induced insulin secretion in hereditary diabetic Goto-Kaki

357 Grill V, Dinesen B, Carlsson S, Efendic S, Pedersen O, Östenson C-G Hyperproinsulinemia and proinsulin to insulin ratios in Swedish middle-aged men: Association with glycemia and insulin resistance but not with family history of diabetes. Am J Epidemiol 155:834-841, 2002 358 Cejvan K, Coy DH, Holst JJ, Cerasi E, Efendic S Gliclazide directly inhibits arginine-induced glucagons release. Diabetes 51 (Suppl 3):S381-S384, 2002 359 Portela-Gomes GM, Grimelius L, Henry J, Efendic S, Wester K, Abdel-Halim SM Increased expression of adenylyl cyclase isoforms in the adrenal gland of diabetic Goto-Kakizaki rat. Applied Immunohistochemistry & Molecular Morphology 10:387-392, 2002 360 Murakawa Y, Zhang W, Pierson CR, Brismar T, Östenson C-G, Efendic S, Sima AAF Impaired glucose tolerance and insulinopenia in the GK-rat causes peripheral Neuropathy. Diabetes Metab Res Rev 18:473-483, 2002 361 Efendic S, Alexander M, Efanov AM, Berggren P-O, Zaitsev SV Two generations of insulintropic imidazoline compounds. Diabetes 51 (Suppl 3): S448-S454, 2002 362 Båvenholm PN, Kühl J, Pigon J, Saha AK, Ruderman NB, Efendic S Insulin resistance in type 2 diabetes: Association with trunctal obesity, impaired fitness and atypical malonyl CoA regulation. J Clin Endocrinol Metab 88:82-87, 2003 363 Cejvan K, Coy DH, Efendic S Intra-islet somatostatin regulates glucagons release via type 2 somatostatin receptors in rats. Diabetes 52:1176-1181, 2003 364 Agardh E, Ahlbom A, Andersson T, Efendic S, Grill V, Hallqvist J, Norman A, Östenson C-G Work stress and low sence of cherence is associated with type 2 diabetes in middle-aged Swedish women. Diabetes Care 26:719-724, 2003 365 Norberg Å, Gruber S, Angelucci F, Renlund S, Wadensten H, Efendic S, Östenson C-G, Jörnvall H , Sillard R, Mathé AA Identification of the bioactive peptide PEC-60 in brain. Cell Mol Life Sci 60:378-381, 2003 366 Portela-Gomes GM, Lukinius A, Ljungberg O, Efendic S, Ahrén B, Abdel-Halim SM PACAP is expressed in secretory granules of insulin and glucagon cells in human and rodent pancreas. Evidence of generation of cAMP compartments uncoupled from hormone release in diabetic islets. Regul Peptides 113:31-39, 2003 367 Goh B-H, Efendic S, Khan A, Portwood N Evidence for the expression of both the hydrolase and translocase components of hepatic glucose-6-phosphatase in murine pancreatic islets. Biochem Biophys Res Comm 307:935-941, 2003 368 Gu HF, Abulaiti A, Östenson C-G, Humphreys K, Wahlestedt C, Brookes AJ, Efendic S Single nucleotide polymorphisms in the proximal promoter region of the adiponectin (APM1) gene are associated with type 2 diabetes in Swedish Caucasians.

Diabetes 53 (Suppl 1) :S31-S35, 2004 369 Davani B, Portwood N, Bryzgalova G, Kvist Reimer M, Heiden T, Östenson C-G, Okret S, Ahrén B, Efendic S, Khan A Aged transgenic mice with increased glucocorticoid sensitivity in the pancreatic β- cells develop diabetes mellitus. Diabetes 53 (Suppl 1):S51-S59, 2004 370 Agardh EE, Ahlbom A, Andersson T, Efendic S, Grill V, Hallqvist J, Östenson C-G Explanations of socioeconomic differences in excess risk of type 2 diabetes in Swedish men and women. Diabetes Care 27:716-721, 2004 371 Agardh EE, Carlsson S, Ahlbom A, Efendic S, Grill V, Hammar H, Hilding A, Östenson C-G Coffee consumption, type 2 diabetes and impaired glucose tolerance in Swedish men and women. J Intern Med 255(6):645-652, 2004 372 Gu HF, Efendic S, Nordman S, Östenson C-G, Brismar K, Brookes AJ, Prince JP Quantitative trait loci near the insulin-degrading enzyme gene (IDE) contribute to variation in plasma insulin levels. Diabetes 53:2137-2142, 2004 373 Bartnik M, Malmberg K, Hamsten A, Efendic S, Norhammar A, Silveira A, Tenerz A, Ohrvik J, Ryden L Abnormal glucose tolerance – a common risk factor in patients with acute myocardial infaraction in comparison with population-based controls. J Intern Med 256:288-297, 2004 374 Kuhl J, Hilding A, Östenson C-G, Grill V, Efendic S, Båvenholm P Characterization of subjects with early abnormalities of glucose tolerance in the Stockholm Diabetes Prevention Program: the impact of gener and type 2 diabetes heredity. Diabetologia 48(1):35-40, 2005 375 Ding B, Kull B, Liu Z, Mottagui-Tabar S, Thonberg H, Gu HF, Brookes AJ, Grundemar L, Karlsson C, Hamsten A, Arner P, Östenson C-G, Efendic S, Monné M, von Heijne G, Eriksson P, Wahlestedt C Human neuropeptide Y signal peptide gain-of-function polymorphism is associated with increased body mass index: possible mode of function. Regul Peptides 127:45- 53, 2005 376 Nordman S, Ding B, Östenson C-G, Kärvestedt L, Brismar K, Efendic S, Gu HF Leu7Pro Polymorphism in the Neuropeptide Y (NPY) gene associated with impaired glucose tolerance and type 2 diabetes in Swedish men. Exp Clin Endocrinol Diabetes 113:1-6, 2005 377 Mosén H, Saleh A, Alm P, Henningsson R, Jimenez-Feltström J, Östenson C- G, Efendic S, Lundquist I Defective glucose-stimulated insulin release in the diabetic Goto-Kakizaki (GK) rat coincides with reduced activity of the islet carbon monoxide signaling pathway. Endocrinology 146(3):1553-1558, 2005 378 Malmberg K, Rydén L, Wedel H, Birkeland K, Bootsma A, Dickstein K, Efendic S, Fisher M, Hamsten A, Herlitz J, Hildebrandt P, MacLeod K, Laakso M, Torp-Pedersen C, Waldenström A; DIGAMI 2 Investigators. Intense metabolic control by means of insulin in patients with diabetes mellitus and

acute myocardial infarction (DIAGAMI 2): effects on mortality and morbidity. Eur Heart J 26(7):650-661, 2005 379 Jacobson PB, von Geldern TW, Öhman L, Österlund M, Wang J, Zinker B, Wilcox D, Nguyen PT, Mika A, Fung S, Fey T, Goos-Nilsson A, Grynfarb M, Barkhem T, Kym PR, Tu N, Link JT, Marsh K, Beno DW, Nguyen BN, Lane BC, Edgerton DS, Cherrington A, Efendic S, Opgenorth TJ Hepatic glucocorticoid receptor antagonism is sufficient to reduce elevated hepatic glucose output and improve glucose control in animal models of type 2 diabetes. J Pharmacol Exp Ther 314(1):191-200, 2005 380 Jörneskog G, Kalan