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Kuehne + Nagel AMS Pharma Gateway Amsterdam Airport Schiphol CoolZone

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Rtm ZV-M 2 Pharma Gateway GxP compliant trained staff KN PharmaChain SOP / WIs outlining all handling procedures Dedicated Pharma team CoolZone temperature controlled storage meeting GxP requirements & having two defined temperature zones (+2C to +8C & +15C to +25C) KN PharmaChain: AMS Pharma Gateway Pharma Gateway Specifics Replace picture AMS CoolZone

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Rtm ZV-M 3 Located at Amsterdam Airport Schiphol Airside facility (direct platform access 1 st Line facility) Close to near by sea ports of Rotterdam, Amsterdam, Moerdijk and Antwerp Well connected to the main European highway network (E19, E35, E22, E231) Excellent hinterland connections in and out of European markets KN PharmaChain: AMS CoolZone Location Schiphol Airport

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Rtm ZV-M 4 KN PharmaChain: AMS CoolZone Airside Facility AMS CoolZone

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Rtm ZV-M 5 24/7/365 operation GxP compliant facility & processes Acts as cross-dock and emergency storage facility Two defined temperature controlled storage areas - +2C to +8C (approx 32 warehouse pallet positions) - +15C to +25C (approx 72 warehouse pallet positions) Temperature controlled acceptance area +15C to +25C temperature controlled portal for temporary storage and cargo acceptances purposes Dedicated cargo loading area for active temperature controlled ULDs KN PharmaChain: AMS CoolZone Specifications Definition of CoolZone: GxP Compliant Two Designated Temperature Zones +2C to +8C & +15C to +25C Where required: PCM and Gel pack Conditioning Areas Freezer Facilities

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Rtm ZV-M 6 KN PharmaChain: AMS CoolZone Facility Layout Restricted access +2C to +8C cool room +15C to +25C cool room Pre-chamber Buffer Zone Direct ramp access ULD re-charging stations Machine room Backup generator Entrance +15C to +25C +2C to +8C

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Rtm ZV-M 7 1 wireless Gateway communication unit located in AMS CoolZone Sensors installed in temperature controlled areas (see pictures) +2C to +8C +15C to +25C Temperature mapped and monitored facility Transmitter supports up to 600 active wireless sensors per location Resident sensors can be added to extend the range of the AMS Gateway Transmits all data to KN Login and will not interfere with existing IT wireless infrastructures Active wireless sensors - activates with a simple push of the button Shipment sensor shown in picture CareTeam proactively monitors the wireless sensor data, taking action when required KN PharmaChain: Wireless Monitoring - AMS CoolZone Connecting Your Sensors For Seamless Data Transmission to KN Login

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Rtm ZV-M 8 Shipment Preparation Repackaging Relabeling Packaging solutions Pre-conditioning Consolidation / deconsolidation Cross-docking Recall possibilities / procedures Customs Services Import / Export customs clearance Fiscal Representation VAT Deferment KN PharmaChain: Value Added Services at AMS CoolZone Additional Options to Fully Customize Your Shipment Needs

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Rtm ZV-M 9 Replenishment Replenishment of dry ice and batteries for active temperature controlled ULDs Phase Change Material and Gel packs Gel packs and Phase Change Materials pre-cooling and exchange Re-charging Recharging stations for active temperature controlled ULDs All heating and cooling types KN PharmaChain: Value Added Services at AMS CoolZone Additional Options to Fully Customize Your Shipment Needs

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Rtm ZV-M 10 KN PharmaChain Road is a specialized and dedicated road network product for the Pharmaceutical and Healthcare industry AMS CoolZone connected to KN PharmaChain road network Temperature mapped trucks with wireless tracking and tracing Wireless tracking and tracing (transmitter - mobile unit) is located on the trucks dashboard for GPS & GPRS connection (temperature monitoring) Dedicated conditioned trucks for pre- and on-carriage Owned equipment includes Mono/Bi-Thermo and double stack trucks Offering daily departures across Europe and beyond from AMS CoolZone Express deliveries and pickups Additional services include: re-icing / gel-pack replenishment Truck temperature control process Kuehne + Nagel also uses a selected number of highly qualified subcontractors for temperature controlled trucking services KN PharmaChain: AMS CoolZone KN PharmaChain Road

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Rtm ZV-M 11 AMS CoolZone staff (performing VALs, shipment preparation) Fully trained & GxP compliant Operational Service Desk Pharma desk - Netherlands CareTeam (Global - 24/7) QSHE Manager Airfreight Facility/QSHE Manager In-line with WHO regulations/GDP Policy KN PharmaChain: AMS CoolZone Your Dedicated NL Pharma Team

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Rtm ZV-M 12 Security cameras (CCTV) 24/7/365 controlled access high security Restricted access Dedicated staff (key card access) Special panel finishing (walls) Temperature controlled areas built with special panel finishing for hygienic solution Backup generator Refrigeration and heating system redundant solution and back-up generator Pre Chamber Provides a temperature buffer between the cargo handling and storage area KN PharmaChain: AMS CoolZone Security features / other

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Rtm ZV-M 13 Kuehne + Nagel is committed to offering environmentally sound, sustainable and innovative supply chain solutions that continually reduce our impact on the environment Green AMS CoolZone features include: Energy efficient lighting (automatic sensors) CO monitored facility PVC Strip curtains saves energy, keep rooms better insulated 100% recyclable panels (CFC free) The refrigerant used has an ODP value of zero Hermetic compressors energy efficient, noise reduction KN PharmaChain: AMS CoolZone Environmentally friendly features

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Rtm ZV-M 14 Why Kuehne + Nagel AMS CoolZone? Your Dedicated Partner Contract Manufacturing Integrated Logistics Service Provider (Sea, Air, Road and Rail, Contract Logistics) Secured solutions for Pharmaceutical & Healthcare goods Focus on Pharmaceutical & Healthcare solutions (dedicated facility) Dedicated range of Pharmaceutical & Healthcare value added services Strong IT Management and temperature monitoring solutions Dedicated Key Account Management / Pharmaceutical & Healthcare Team Global Coverage & Network (1000 offices worldwide) In-house Customs department / Insurance (Nacora) AMS CoolZone located in heart of European consumer belt and excellent transport connections Local NL QSHE is well connected and aligned to our Global QSHE (SGI) team

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Thank you for your attention