2004

Amino acidsU 0400 Kowalski Ester Homologation. Application to the Synthesis of β-Amino Esters.

— The Kowalski homologation protocol is successfully extended to α-amino esters to give the corresponding β-amino esters in moderate yields and without racemization. Best results are achieved with N-benzyl derivatives while the corresponding N-Boc derivatives are less suitable to this protocol [cf. (Ia) vs. (Ib)]. — (GRAY, D.; CONCELLON, C.; GALLAGHER*, T.; J. Org. Chem. 69 (2004) 14, 4849-4851; Sch. Chem., Univ. Bristol, Cantock's Close, Bristol BS8 1TS, UK; Eng.) — Mischke

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