Konstantinos Poulas Symposium
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Transcript of Konstantinos Poulas Symposium
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Konstantinos Poulas
Associate Professor,
Department of Pharmacy, University of Patras
KPJ Conference 2014
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Nerve cells areconnected to oneanother by specialelectrical circuitsknown as synapses,which prevent thebodys electricalsystemthe brain,spinal cord andnervesfrom beingdamaged.
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Modern medicine used to focus for intervention onthree main (although not exclusive) approaches:
A. surgery,
B. irradiation and, C. (Bio)chemistry.
This trinity does not capitalize on one modality
long known for its key role in many functions in celland, most important, in whole organism level:electric currents.
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There is indication enough that therapeutic use of electric currents orfields (which result in currents) may exert its therapeutic potential atan upstream levelcompared to chemicals
Such protocols may be used uniformly for multiple ailments with acommon basis; such grouping may be much larger and moregeneralized than similar ones currently attainable by biochemicalpharmaceuticals.
Thus, the concept of "electroceuticals" emerges, which is used to
describe different modalities, differing in principle, form, quantity,time and other parameters, but focused on administering an externalor induced electrical current for amending impaired biologicalfunctions.
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http://www.nature.com/nature/journal/v496/n7444/full/496159a.html?WT.ec_id=NATURE-20130411http://www.nature.com/nature/journal/v496/n7444/full/496159a.html?WT.ec_id=NATURE-20130411http://www.nature.com/nature/journal/v496/n7444/full/496159a.html?WT.ec_id=NATURE-20130411http://www.nature.com/nature/journal/v496/n7444/full/496159a.html?WT.ec_id=NATURE-20130411http://www.nature.com/nature/journal/v496/n7444/full/496159a.html?WT.ec_id=NATURE-20130411http://www.nature.com/nature/journal/v496/n7444/full/496159a.html?WT.ec_id=NATURE-20130411http://www.nature.com/nature/journal/v496/n7444/full/496159a.html?WT.ec_id=NATURE-20130411http://www.nature.com/nature/journal/v496/n7444/full/496159a.html?WT.ec_id=NATURE-20130411http://www.nature.com/nature/journal/v496/n7444/full/496159a.html?WT.ec_id=NATURE-20130411http://www.nature.com/nature/journal/v496/n7444/full/496159a.html?WT.ec_id=NATURE-20130411 -
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Chronology
Accomplishments-events
1stmillennium BC Amber and magnetite (static electrism) used by Egyptians for headache and arthritis.
420 BC Hippocrates prescribes shocks from torpedo fish
5thc BC Asklepeia near ionized water environment (falls).
17thc AD Golden artifacts, charged, to treat smallpox lesions.
1752
Franklinism by Ben Franklin; static electricity to relieve pain.
1800s Galvanism; DC to relieve pain.
1825 Sarlandiere and Berlioz combine Galvanism ES and acupuncture.
1832 Faradism; use of AC for ES; Duchenne employs it for muscle stimulation.
1850
Publication of the use of ES for bone fractures in US.
1888
DArsonvalisation: use of high frequency currents.
1900
Carnage foundation establishes Fleiner committee.
1910 Fleiner results discontinue ES in the US.
1930s
ES modalities actively marketed in Europe.
1944
Galvanic Exercise for wounded personnel of US Armed Forces.
1957
Electric properties of the bone first published by Fukada & Yasuda.
1960s
ES effect on cell wall-principle of electroporation.
1967
Wall &Sweat: 100Hz ES in skin proved analgesic.
1970s Bruce Lee perfects galvanic exercise for accelerated training.
1980s
Regular ES use in sports injuries and muscle atrophy; discovery of skin battery potentials; antimicrobial effect of ES invivo, usual treatment of bone fractures.
1982
Cheng et al publish the impact of ES to ATP generation.
1990s
Wound healing by ES becomes prominent.
2000s
Development of NCCT combining different ES schemes advantages.
2010s
Massive development of different ES schemes and approaches.
2013
Concept of electroceuticals.
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Difficulties I) The electrodes can cause pain
II) Difficulties in usage
III) Infection danger
IV) Can not be used for large wounds
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(
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WMCSWireless Micro Current Stimulation
O2 O2 -
e -
Return connection
Current of injury
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The International Journal of
Lower Extremity Wounds , In
press
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Current of Injury
Potential difference
Cells of repair
Electric fields in the edge of thewound
A healthy wound heal from the edge
In a chronic wound this process is interrupted
Healing of wounds by the use of Electrical Stimulation
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60 years old stroke patient
for the last 9 years. Hepresented with a 8cm ulcer,
and was admitted in the
hospital with severe
infection.
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60 years old stroke patient
for the last 9 years. Hepresented with a 8cm ulcer,
and was admitted in the
hospital with severe
infection.
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60 years old stroke patient
for the last 9 years. Hepresented with a 8cm ulcer,
and was admitted in the
hospital with severe
infection.
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WMCS and Burns
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Sections of skin at days 0 and 5 (post WMCS therapy).
(a) wound in the beginning(b) vascular proliferation with presence of fibroblasts
increased myofibroblastic proliferation = COLLAGEN
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Crystallization = aggregation (change of surface electrostaticproperties???)
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