KNOWLEDGE ALERT Date: 19th April 2016

This bulletin highlights recently produced documents and items of interest that have appeared on websites (coverage may not be comprehensive). If you have any comments or suggestions regarding this Bulletin, please email the library library@sthk.nhs.uk. All links are correct at time of publishing. If a link is broken please email the library and we will send you the correct link/document. Some documents are large and may take time to open so please be patient when waiting for links to open. If you have received this bulletin from a third party and would like to receive it direct please email the library. Library Contact Details: Library and Knowledge Service, St Helens & Knowsley Health Informatics, Level 1 Nightingale House, Whiston Hospital, Warrington Road, Prescot, Merseyside L35 5DR www.knowledge-nw.nhs.uk

CONTENTS:

ALLIED HEALTH PROFESSIONALS ANAESTHESIA CANCER CARDIOLOGY CARERS CHILDREN & YOUNG PEOPLE COMMISSIONING DIAGNOSTICS EDUCATION & TRAINING EMERGENCY MEDICINE/CRITICAL CARE GENERAL MEDICINE GENERAL PRACTICE AND PRACTICE MANAGEMENT GENERAL SURGERY HEALTH SERVICES MANAGEMENT IMMUNISATION INFECTION CONTROL AND INFECTIOUS DISEASES INFORMATICS AND INFORMATION GOVERNANCE LEARNING DISABILITIES MATERNITY & GYNAECOLOGY MEDICINES MANAGEMENT/PHARMACY MENTAL HEALTH AND WELLBEING NEUROLOGY NURSING PRACTICE OPHTHALMOLOGY ORTHOPAEDICS PALLIATIVE CARE PATHOLOGY PATIENT SAFETY PUBLIC HEALTH/HEALTH IMPROVEMENT RADIOLOGY RESEARCH RESPIRATORY

SEXUAL HEALTH ________________________________________________________________________

ALLIED HEALTH PROFESSIONALS Helping you find the information you need This National Institute for Health and Care Excellence (NICE) blog explains how they have improved their guidance pages to make it easier to find the information you need. Blog: https://www.nice.org.uk/news/blog/helping-you-find-the-information-you-need Online workshop aims to create a ‘vision’ for allied health professions An NHS England e-workshop offers people in the allied health professions (AHPs) a chance to share their opinions about the future of health services. News: http://www.csp.org.uk/news/2016/04/18/online-workshop-aims-create-vision-allied-health-professions Blog: https://www.england.nhs.uk/2016/04/suzanne-rastrick-6/

ANAESTHESIA Statement on junior doctors' dispute The Royal College of Anaesthetists (RCoA) has made a statement regarding the escalation of the dispute. Statement: http://www.rcoa.ac.uk/news-and-bulletin/rcoa-news-and-statements/statement-junior-doctors-dispute

CANCER Comparative Effectiveness Review number 174: Imaging for the Pretreatment Staging of Small Cell Lung Cancer This review found evidence is sparse on imaging modalities in the pretreatment staging of small cell lung cancer. However the authors managed to draw three conclusions about comparative accuracy: (1) Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is more sensitive than multidetector computed tomography (MDCT) for detecting osseous metastases; (2) FDG PET/CT is more sensitive than bone scintigraphy for detecting osseous metastases; (3) Standard staging plus FDG PET/CT is more sensitive than standard staging alone for detecting any distant metastases. Systematic review: https://www.effectivehealthcare.ahrq.gov/ehc/products/595/2211/lung-cancer-staging-report-160414.pdf Toward Precision Therapy for Children with Cancer: An Interview with Dr Javed Khan Based on the results of a new study, the National Cancer Institute (NCI) is launching a clinical program called ClinOmics, which will use genomic approaches to help guide the treatment of patients with cancer who are treated at the National Institutes of Health (NIH) Clinical Center. In this interview, Javed Khan, M.D., of NCI’s Center for Cancer Research (CCR), discusses the promise and the challenges of genome-based therapy for children and adults with cancer. Further information: http://www.cancer.gov/news-events/cancer-currents-blog/2016/nci-clinomics-pediatric Abstract: http://clincancerres.aacrjournals.org/content/early/2016/03/18/1078-0432.CCR-15-2717.abstract Article (PDF): http://clincancerres.aacrjournals.org/content/early/2016/03/18/1078-0432.CCR-15-2717.full.pdf+html Skin cancer: Pair of drugs 'eliminate 20% of tumours' A fifth of people with advanced melanoma have no sign of tumours in their body after treatment with a pair of immunotherapy drugs, a study shows. The first survival data on using ipilimumab and nivolumab in combination showed 69% of patients, in a trial on 142, were still alive after two years. UK doctors leading the trial said the results were "very encouraging". News: http://www.bbc.co.uk/news/health-36043882 Abstract: http://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=4017&sKey=371fa616-a0cf-4bf8-993d-ce424853b52c&cKey=d4d67737-7e76-4133-9869-263896d727e8&mKey=1d10d749-4b6a-4ab3-bcd4-f80fb1922267

AACR 2016: Delays in radiation therapy increase chance of breast tumour development in women treated for ductal carcinoma in situ Women who underwent treatment for ductal carcinoma in situ (DCIS), a noninvasive breast abnormality, were at higher risk of developing malignant breast tumours if they did not receive timely radiation therapy as part of their treatment, according to a study presented at the American Association for Cancer Research (AACR) Annual Meeting 2016. News: http://ecancer.org/news/9077-aacr-2016--delays-in-radiation-therapy-increase-chance-of-breast-tumour-development-in-women-treated-for-ductal-carcinoma-in-situ.php Abstract: http://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=4017&sKey=ac4b77a1-3d78-4c6f-941b-1e77ea4a4ab2&cKey=591aed3e-4709-44a8-8704-b70e214d1fe5&mKey=1d10d749-4b6a-4ab3-bcd4-f80fb1922267 AACR 2016: Physical activity may improve prostate cancer prognosis Prostate cancer patients and survivors who maintain a moderate to high level of physical activity may improve their survival prognosis, according to research presented at the American Association for Cancer Research (AACR) Annual Meeting 2016. News: http://ecancer.org/news/9071-aacr-2016--physical-activity-may-improve-prostate-cancer-prognosis.php Abstract: http://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=4017&sKey=d33d7049-eb65-4cf1-8d47-1eb572294216&cKey=4fd07bf1-c184-4c6b-aeba-081fe4de992b&mKey=1d10d749-4b6a-4ab3-bcd4-f80fb1922267 AACR 2016: Results from clinical trial of personalised cellular therapy in brain tumours Immune cells engineered to seek out and attack a type of deadly brain cancer known as glioblastoma (GBM) were found to have an acceptable safety profile and successfully migrate to and infiltrate tumours, researchers from Penn Medicine and Harvard University reported at the American Association for Cancer Research (AACR) Annual Meeting 2016. News: http://ecancer.org/news/9143-aacr-2016--results-from-clinical-trial-of-personalised-cellular-therapy-in-brain-tumours.php Abstract: http://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=4017&sKey=826269b3-49e3-449d-b2cc-5a95aafb9aa4&cKey=73dbe411-6dcf-4d29-9e93-22c94c393587&mKey=1d10d749-4b6a-4ab3-bcd4-f80fb1922267 AACR 2016: Three years and counting on atezolizumab for stage 4 CRC patient, Rodney Bearfoot A symposium presented at the American Association for Cancer Research (AACR) Annual Meeting 2016 offers updated results on the ongoing phase 1b clinical trial of anti-PDL1 immunotherapy atezolizumab in advanced stage colorectal cancer patients. News: http://ecancer.org/news/9110-aacr-2016--three-years-and-counting-on-atezolizumab-for-stage-4-crc-patient--rodney-bearfoot.php Abstract: http://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=4017&sKey=a840f1f2-4954-4f9c-a483-a85117578610&cKey=7584fade-8cff-49cf-a8b4-f36a5a5946f7&mKey=1d10d749-4b6a-4ab3-bcd4-f80fb1922267 AACR 2016: MammaPrint genetic test can reduce use of post-surgery chemotherapy among early-stage breast cancer patients Among patients with early-stage breast cancer who were considered at high risk for disease recurrence based on clinical and biological criteria, the MammaPrint genetic test identified a large group of patients for whom five-year distant metastasis–free survival was equally good whether or not they received adjuvant chemotherapy (chemotherapy given post-surgery), according to results from the randomised, phase III microarray in node negative disease may avoid chemotherapy (MINDACT) clinical trial to be presented at the American Association for Cancer Research (AACR) Annual Meeting 2016, April 16-20. News: http://ecancer.org/news/9135-aacr-2016--mammaprint-genetic-test-can-reduce-use-of-post-surgery-chemotherapy-among-early-stage-breast-cancer-patients.php Abstract: http://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=4017&sKey=33e51b6a-c17a-44b4-8d60-181308817ce7&cKey=59e341be-7abd-4de2-9c7f-d91835cc3d85&mKey=1d10d749-4b6a-4ab3-bcd4-f80fb1922267 New human papillomavirus (HPV) vaccine could curb cervical cancers and health costs if adopted widely

A Yale-led study finds that a new vaccine for human papillomavirus (HPV) would significantly reduce both cervical cancer incidence and healthcare costs if states coordinated policies to improve coverage. News: http://ecancer.org/news/9117-new-hpv-vaccine-could-curb-cervical-cancers-and-health-costs-if-adopted-widely.php Abstract: http://www.pnas.org/content/early/2016/04/13/1515528113.abstract Metastasis-promoting circulating tumour cell clusters pass through capillary-sized vessels Investigators have found that circulating tumour cell (CTC) clusters - which are more efficient in spreading cancer throughout the body than are single CTCs - can pass through capillary-sized blood vessels. Their findings, which contradict the widely-held belief that CTC clusters are too large to pass through capillaries, suggest potential strategies to reduce clusters' metastatic potential. News: http://ecancer.org/news/9142-metastasis-promoting-circulating-tumour-cell-clusters-pass-through-capillary-sized-vessels.php Abstract: http://www.pnas.org/content/early/2016/04/13/1524448113.abstract Article (PDF): http://www.pnas.org/content/early/2016/04/13/1524448113.full.pdf?with-ds=yes Evidence showing new drug combination may improve outcomes for women with advanced breast cancer when administered before surgery Results from the I-SPY 2 trial show that giving patients with HER2-positive invasive breast cancer a combination of the drugs trastuzumab emtansine (T-DM1) and pertuzumab before surgery was more beneficial than the combination of paclitaxel plus trastuzumab. Previous studies have shown that a combination of T-DM1 and pertuzumab is safe and effective against advanced, metastatic HER2-positive breast cancer, but in the new results, investigators tested whether the combination would also be effective if given earlier in the course of treatment. News: http://ecancer.org/news/9144-evidence-showing-new-drug-combination-may-improve-outcomes-for-women-with-advanced-breast-cancer-when-administered-before-surgery.php Abstract: http://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=4017&sKey=33e51b6a-c17a-44b4-8d60-181308817ce7&cKey=d2579a20-62ac-477b-861d-14473af2bfcb&mKey=1d10d749-4b6a-4ab3-bcd4-f80fb1922267 Demand for radiotherapy will rise substantially over next ten years; planning to deal with increase in new cancer cases should start now The demand for radiotherapy across all European countries will increase by an average of 16% between 2012 and 2025, with the highest expected increase being for prostate cancer cases (24%), according to a new study published in Radiotherapy and Oncology. These projections come from a new study by HERO, the Health Economics in Radiation Oncology project of the European Society for Radiotherapy and Oncology. The results will also be presented on the 3rd day of the ESTRO 35 conference (Sunday 1st May), to be held in Turin, Italy, from Friday 29 April – Tuesday 3 May 2016. News: http://www.alphagalileo.org/ViewItem.aspx?ItemId=163219&CultureCode=en Journal abstract: http://www.thegreenjournal.com/article/S0167-8140(16)00074-8/abstract How to improve your patient’s understanding of consent and data protection In response to the need for improved communication with patients, ecancer and the Institute for Legal Informatics in Hannover have created four educational videos on medical data protection. To make the information accessible for patients, the videos have also been turned into four e-learning modules. Further information: http://ecancer.org/news/9152-how-to-improve-your-patient---s-understanding-of-consent-and-data-protection.php Combination therapy may offer better outcomes for patients with retinoblastoma Researchers have demonstrated that targeting survivin - a protein that inhibits apoptosis or cell death - enhances the effectiveness of chemotherapy in cells and mouse models of retinoblastoma (Rb), the most common malignant tumour of the eye in children. News: http://ecancer.org/news/9151-combination-therapy-may-offer-better-outcomes-for-patients-with-retinoblastoma.php Article: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153011 Experimental drug guadecitabine found safe in patients with colorectal cancer In a small, phase I clinical trial, Johns Hopkins Kimmel Cancer Center researchers say they show for the first time that the experimental drug guadecitabine (SGI-110) is safe in combination with the chemotherapy drug irinotecan and may overcome resistance to irinotecan in patients with metastatic colorectal cancer.

News: http://ecancer.org/news/9148-experimental-drug-guadecitabine-found-safe-in-patients-with-colorectal-cancer.php Abstract: http://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=4017&sKey=946fbd6f-3560-4ea2-aed6-7788155ea81b&cKey=ebdf78e4-e1d9-4316-beff-c6780b65aee1&mKey=1d10d749-4b6a-4ab3-bcd4-f80fb1922267 Preliminary study: Antibody therapy reduces cancer stem cells in multiple myeloma An experimental antibody treatment decreased by half the number of cancer stem cells that drive the growth of tumours in nearly all patients with multiple myeloma, a cancer of the bone marrow and bone tissue, according to results of a preliminary clinical trial led by Johns Hopkins Kimmel Cancer Center scientists. News: http://ecancer.org/news/9147-preliminary-study--antibody-therapy-reduces-cancer-stem-cells-in-multiple-myeloma.php Abstract: http://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=4017&sKey=6a4c9388-20eb-464f-98c9-810c4a933251&cKey=63c96283-4420-4232-a40f-1f9d9fa4cbdf&mKey=1d10d749-4b6a-4ab3-bcd4-f80fb1922267 Low fat diet helps postmenopausal women avoid deadly breast cancers Women who stayed on a low fat diet for approximately eight years reduced their risk of death from invasive breast cancers and improved their survival rates when compared with women who had not followed the dietary regimen, according to a study presented at a clinical trial plenary session at the American Association for Cancer Research (AACR) annual meeting. News: http://ecancer.org/news/9146-low-fat-diet-helps-postmenopausal-women-avoid-deadly-breast-cancers.php Abstract: http://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=4017&sKey=33e51b6a-c17a-44b4-8d60-181308817ce7&cKey=c6d3e92e-4d28-43c3-ab93-faf799e66c85&mKey=1d10d749-4b6a-4ab3-bcd4-f80fb1922267

CARDIOLOGY Researchers identify enzyme link between excessive heart muscle growth, cancer growth University of Texas (UT) Southwestern Medical Center cardiology researchers have identified molecular ties between the growth of cancer cells and heart cells that suggest existing cancer drugs may be able to help those with enlarged heart cells -- a condition that can lead to heart attacks and stroke. News: http://www.utsouthwestern.edu/newsroom/news-releases/year-2016/april/cardiac-hypertrophy-hill.html Abstract: http://stke.sciencemag.org/content/9/422/ra34.abstract Cardiovascular Horizon Scanning Bulletin 2016 Volume 8 Issue 4 Bringing together best practice, innovation and future risks to support the commissioning process and service redesign. Bulletin: https://cardionwpctl.wordpress.com/category/volume-8-issue-4/

CARERS Outcomes Focussed Health and WellBeing Service Crossroads are a specialist charitable organisation who provide practical help, support and social opportunities through a variety of projects to carers and those they care for of all ages and disabilities throughout Herefordshire. In October 2015 Herefordshire Council commissioned Crossroads to deliver a new outcomes focused Health and Wellbeing Service to support carers who have been through the Social Care assessment process and been found to have eligible needs. Further information: http://www.fabnhsstuff.net/2016/04/17/outcomes-focussed-health-wellbeing-service/ Double whammy: transitioning from children’s to adult services and transitioning to adulthood Blog from: Marija Trachtenberg, Research Officer, Personal Social Services Research Unit (PSSRU), The London School of Economics and Political Science (LSE). Blog: http://blogs.lse.ac.uk/healthandsocialcare/2016/04/18/double-whammy-transitioning-from-childrens-to-adult-services-and-transitioning-to-adulthood/

Care Act 2014 Part 1: factsheets (Updated) The Care Act factsheets have been updated to reflect changes made to the Care Act statutory guidance. Factsheets: https://www.gov.uk/government/publications/care-act-2014-part-1-factsheets/care-act-factsheets Associated documents: https://www.gov.uk/government/publications/care-act-2014-part-1-factsheets

CHILDREN & YOUNG PEOPLE Transforming the care of children and young people in the capital with asthma Healthy London Partnership is a collaboration between London’s 32 clinical commissioning groups (CCGs) and NHS England London region to support better health for London. A group of leading clinicians and commissioners from across the capital were brought together to develop a set of standards for care of children and young people with asthma and pre-school/viral induced wheeze to complement the existing London Quality Standards, Primary Care Commissioning Framework and Children and Young People’s Acute Care Standards. Further information: http://www.fabnhsstuff.net/2016/04/17/transforming-care-children-young-people-capital-asthma/ EVENT: Talking about Sex, Sexuality and Relationships: Translating the Standards and Guidance into Practice This (free of charge) Masterclass aims to provide greater understanding and awareness of the needs of young people with life-limiting or life-threatening conditions in relation to sex, sexuality and relationships. Further information: https://www2.togetherforshortlives.org.uk/portal/public/event/eventBooking.aspx?id=EVT00336 A simple bang on the head can alter a child's relationship with their parents claim academics All mums and dads worry about their children banging their heads in case it causes a serious injury. But such an accident can also harm the bond between parent and child, scientists warn. Around one in 50 under-fives a year suffers concussion, but there has been little research into its effects. Now a study has found it can damage the youngsters’ social interactions – including with their parents. News: http://www.dailymail.co.uk/news/article-3544700/A-simple-bang-head-alter-child-s-relationship-parents-claim-academics.html Abstract: http://onlinelibrary.wiley.com/doi/10.1111/jnp.12104/abstract Behind the Headlines: http://www.nhs.uk/news/2016/04April/Pages/Childs-head-injury-could-damage-child-parent-relationships.aspx Double whammy: transitioning from children’s to adult services and transitioning to adulthood Blog from: Marija Trachtenberg, Research Officer, Personal Social Services Research Unit (PSSRU), The London School of Economics and Political Science (LSE). Blog: http://blogs.lse.ac.uk/healthandsocialcare/2016/04/18/double-whammy-transitioning-from-childrens-to-adult-services-and-transitioning-to-adulthood/ Uniting Children’s Community Nurses Together Becky Hepworth, Community Children's Nurse Team Leader, Isle of Wight NHS Trust explains how she uses Twitter to connect with other Community Children's Nurses. Further information: http://www.fabnhsstuff.net/2016/04/18/uniting-childrens-community-nurses-together/ Birth cohort tables for infant deaths, England and Wales: 2013 Infant deaths figures reported in these tables represent babies born in 2013 who died before their first birthday: the 2013 birth cohort for infant deaths. This includes babies who died either in 2013 or in 2014 and were under 1 year of age. Statistics: https://www.ons.gov.uk/releases/birthcohorttablesforinfantdeathsenglandandwales2013 Child mortality in England and Wales: 2014

This bulletin presents final statistics on infant deaths and childhood deaths that occurred in England and Wales in 2014. It also contains additional statistics on some of the main risk factors affecting infant deaths, including age of mother and birthweight. Statistics: https://www.ons.gov.uk/releases/childmortalityinenglandandwales2014

COMMISSIONING Technological advances both threaten our mental health and give us means to improve it Blog from: Craig Thorley, Research Fellow, IPPR. Blog: http://www.ippr.org/blog/technological-advances-both-threaten-our-mental-health-and-give-us-means-to-improve-it Transforming the care of children and young people in the capital with asthma Healthy London Partnership is a collaboration between London’s 32 clinical commissioning groups (CCGs) and NHS England London region to support better health for London. A group of leading clinicians and commissioners from across the capital were brought together to develop a set of standards for care of children and young people with asthma and pre-school/viral induced wheeze to complement the existing London Quality Standards, Primary Care Commissioning Framework and Children and Young People’s Acute Care Standards. Further information: http://www.fabnhsstuff.net/2016/04/17/transforming-care-children-young-people-capital-asthma/ Social Prescribing the Vanguard Way Two blogs help to explain what Social Prescribing is by detailing the work being done in the West Wakefield Health and Wellbeing Vanguard. Further information: http://www.fabnhsstuff.net/2016/04/17/theblonde-gets-to-understand-social-prescribing-the-vanguard-way/ Outcomes Focussed Health and WellBeing Service Crossroads are a specialist charitable organisation who provide practical help, support and social opportunities through a variety of projects to carers and those they care for of all ages and disabilities throughout Herefordshire. In October 2015 Herefordshire Council commissioned Crossroads to deliver a new outcomes focused Health and Wellbeing Service to support carers who have been through the Social Care assessment process and been found to have eligible needs. Further information: http://www.fabnhsstuff.net/2016/04/17/outcomes-focussed-health-wellbeing-service/ Helping you find the information you need This National Institute for Health and Care Excellence (NICE) blog explains how they have improved their guidance pages to make it easier to find the information you need. Blog: https://www.nice.org.uk/news/blog/helping-you-find-the-information-you-need NHS England primary care website data update NHS England has updated two modules on the primary care website: general practice outcome standards (GPOS) and the general practice high level indicators (GPHLI). Supporting resources list all indicators, data sources and time periods. Website: https://www.primarycare.nhs.uk/

Double whammy: transitioning from children’s to adult services and transitioning to adulthood Blog from: Marija Trachtenberg, Research Officer, Personal Social Services Research Unit (PSSRU), The London School of Economics and Political Science (LSE). Blog: http://blogs.lse.ac.uk/healthandsocialcare/2016/04/18/double-whammy-transitioning-from-childrens-to-adult-services-and-transitioning-to-adulthood/ Privatisation and independent sector provision of NHS healthcare The BMA surveyed members on their opinions of independent sector provision of NHS healthcare. This report uses these results, as well as data from a number of privatisation indicators, to make eight recommendations regarding independent sector provision of NHS healthcare. Report: http://www.bma.org.uk/-/media/files/pdfs/working%20for%20change/policy%20and%20lobbying/bma-independentsectorprovisionofnhscare-18042016-2.pdf

Associated documents: http://www.bma.org.uk/working-for-change/policy-and-lobbying/funding/privatisation-and-independent-sector-providers-in-nhs-care News: http://www.bma.org.uk/news-views-analysis/news/2016/april/bma-report-calls-for-safeguards-against-fragmented-nhs Blog: http://www.bma.org.uk/news-views-analysis/news/2016/april/rescue-bid-for-quality-of-care NHS Partners Network response: http://www.nhsconfed.org/media-centre/2016/04/role-of-the-independent-sector-in-delivering-nhs-care A strong constitution The Primary Care Today (PCT) weekly feature is about CCG constitutions. CCG constitutions are important legal documents. But to remain flexible and relevant to changes in CCG powers, they need to be reviewed and updated regularly. Article: http://primarycaretoday.co.uk/commissioning/strong-constitution Implementing the Cancer Taskforce Recommendations: Commissioning person centred care for people affected by cancer This guidance is intended to support commissioners and strategic clinical networks to take the actions necessary to drive improved outcomes for person centred care through cancer commissioning. It describes tested interventions that NHS England expects to be in place to meet the needs of people affected by cancer. Guidance: https://www.england.nhs.uk/wp-content/uploads/2016/04/cancer-guid.pdf NHS should work “hand-in-glove” with housing and care, says health spokesman There is an increasingly urgent need for housing to work more closely with health and social care for the wellbeing of the public, according to Labour’s health spokesman. Further information: http://primarycaretoday.co.uk/news/nhs-should-work-%E2%80%9Chand-glove%E2%80%9D-housing-and-care-says-health-spokesman Cardiovascular Horizon Scanning Bulletin 2016 Volume 8 Issue 4 Bringing together best practice, innovation and future risks to support the commissioning process and service redesign. Bulletin: https://cardionwpctl.wordpress.com/category/volume-8-issue-4/ EVENT: Urgent and emergency care With the urgent care system under pressure and attendances to major A&Es increasing year on year, this King’s Fund conference will demonstrate how to improve the coordination of services and reduce pressure on A&E departments. Further information: http://www.kingsfund.org.uk/events/urgent-and-emergency-care-1 VIDEO: Better Local Care – it’s what we all want isn’t it? This video discusses the Better Local Care initiatives that are taking place in South West New Forest. Video: http://www.fabnhsstuff.net/2016/04/18/better-local-care-its-what-we-all-want-isnt-it/ Quality Outcomes Framework (QOF) Recorded Dementia Diagnoses - March 2016 The Health & Social Care Information Centre (HSCIC) collects data on dementia diagnoses by GPs in support of the national dementia strategy. The data is also used for quality and outcome framework (QOF) reporting and payments. Statistics: http://www.hscic.gov.uk/catalogue/PUB20516 Learning Disability Services Monthly Statistics - England Commissioner Census (Assuring Transformation) - March 2016, Experimental Statistics This statistical release makes available the most recent data relating to patients with learning disabilities and/or autism spectrum disorder receiving inpatient care commissioned in England. Statistics: http://www.hscic.gov.uk/catalogue/PUB20499 Care Act 2014 Part 1: factsheets (Updated) The Care Act factsheets have been updated to reflect changes made to the Care Act statutory guidance. Factsheets: https://www.gov.uk/government/publications/care-act-2014-part-1-factsheets/care-act-factsheets Associated documents: https://www.gov.uk/government/publications/care-act-2014-part-1-factsheets

DIAGNOSTICS Quality Outcomes Framework (QOF) Recorded Dementia Diagnoses - March 2016 The Health & Social Care Information Centre (HSCIC) collects data on dementia diagnoses by GPs in support of the national dementia strategy. The data is also used for quality and outcome framework (QOF) reporting and payments. Statistics: http://www.hscic.gov.uk/catalogue/PUB20516

EDUCATION & TRAINING An inside look into the Clinical Skills Log app Primary Care Today caught up with Andrew Ormerod, research paramedic behind the smart app which allows clinicians to record skills and identify gaps in their practice. News: http://primarycaretoday.co.uk/news/inside-look-clinical-skills-log-app Further information: http://clinicalskillslog.co.uk/

EMERGENCY MEDICINE/CRITICAL CARE The trauma of too much information Blog from: Jon Holley, CT2 Doctor Trauma & Orthopaedics and National Medical Director’s Fellow, National Institute for Health and Care Excellence (NICE). Blog: https://www.nice.org.uk/news/blog/the-trauma-of-too-much-information EVENT: Urgent and emergency care With the urgent care system under pressure and attendances to major A&Es increasing year on year, this King’s Fund conference will demonstrate how to improve the coordination of services and reduce pressure on A&E departments. Further information: http://www.kingsfund.org.uk/events/urgent-and-emergency-care-1

GENERAL MEDICINE Helping you find the information you need This National Institute for Health and Care Excellence (NICE) blog explains how they have improved their guidance pages to make it easier to find the information you need. Blog: https://www.nice.org.uk/news/blog/helping-you-find-the-information-you-need Statement on junior doctors' dispute The Royal College of Anaesthetists (RCoA) has made a statement regarding the escalation of the dispute. Statement: http://www.rcoa.ac.uk/news-and-bulletin/rcoa-news-and-statements/statement-junior-doctors-dispute An inside look into the Clinical Skills Log app Primary Care Today caught up with Andrew Ormerod, research paramedic behind the smart app which allows clinicians to record skills and identify gaps in their practice. News: http://primarycaretoday.co.uk/news/inside-look-clinical-skills-log-app Further information: http://clinicalskillslog.co.uk/ Statesmanship among medical leaders could help resolve the junior doctors’ dispute Blog from: Chris Ham, Chief Executive, The King’s Fund. Blog: http://www.kingsfund.org.uk/blog/2016/04/junior-doctors-contract-dispute Urgent Question on imposition of new junior doctor contract Secretary of State for Health, Jeremy Hunt, responded to an Urgent Question asked by Shadow Secretary of State for Health, Heidi Alexander, in the House of Commons on the imposition of a new junior doctor contract. Further information: http://www.parliament.uk/business/news/2016/april/urgent-question-on-imposition-of-new-junior-doctor-contract/

Double whammy: transitioning from children’s to adult services and transitioning to adulthood Blog from: Marija Trachtenberg, Research Officer, Personal Social Services Research Unit (PSSRU), The London School of Economics and Political Science (LSE). Blog: http://blogs.lse.ac.uk/healthandsocialcare/2016/04/18/double-whammy-transitioning-from-childrens-to-adult-services-and-transitioning-to-adulthood/ The dogs that don’t bark are the most difficult to hear Blog from: Paul Hodgkin, former GP, founder and current Chair, Patient Opinion. Blog: http://blogs.bmj.com/bmj/2016/04/18/paul-hodgkin-the-dogs-that-dont-bark-are-the-most-difficult-to-hear/ Journal review – 18 April 2016 Blog from: Richard Lehman, GP, Oxfordshire. Blog: http://blogs.bmj.com/bmj/2016/04/18/richard-lehmans-journal-review-18-april-2016/

GENERAL PRACTICE AND PRACTICE MANAGEMENT Transforming the care of children and young people in the capital with asthma Healthy London Partnership is a collaboration between London’s 32 clinical commissioning groups (CCGs) and NHS England London region to support better health for London. A group of leading clinicians and commissioners from across the capital were brought together to develop a set of standards for care of children and young people with asthma and pre-school/viral induced wheeze to complement the existing London Quality Standards, Primary Care Commissioning Framework and Children and Young People’s Acute Care Standards. Further information: http://www.fabnhsstuff.net/2016/04/17/transforming-care-children-young-people-capital-asthma/ Social Prescribing the Vanguard Way Two blogs help to explain what Social Prescribing is by detailing the work being done in the West Wakefield Health and Wellbeing Vanguard. Further information: http://www.fabnhsstuff.net/2016/04/17/theblonde-gets-to-understand-social-prescribing-the-vanguard-way/ GPs are leading the way on NHS transformation As the government and NHS England prepare to unveil a ‘roadmap’ for family doctors, primary care is beginning to shift the centre of gravity away from hospitals. Article: http://www.theguardian.com/healthcare-network/2016/apr/15/gps-leading-nhs-transformation Junior doctors contract: Jeremy Hunt's legal power to impose new contract questioned A letter sent by Government lawyers says the Health Secretary is 'introducing' the contract, rather than 'imposing' it upon junior doctors. News: http://www.independent.co.uk/news/uk/politics/junior-doctors-contract-jeremy-hunts-legal-power-to-impose-new-contract-questioned-a6988831.html Hints & Tips – Dispensing Contractors: Issue 23 Latest issue. Bulletin: http://www.nhsbsa.nhs.uk/Documents/PrescriptionServices/Dispensing_Contractors_-_Issue_23_(V1).pdf Helping you find the information you need This National Institute for Health and Care Excellence (NICE) blog explains how they have improved their guidance pages to make it easier to find the information you need. Blog: https://www.nice.org.uk/news/blog/helping-you-find-the-information-you-need NHS England primary care website data update NHS England has updated two modules on the primary care website: general practice outcome standards (GPOS) and the general practice high level indicators (GPHLI). Supporting resources list all indicators, data sources and time periods. Website: https://www.primarycare.nhs.uk/

Warning issued over alarming rise in 'super-gonorrhoea' cases Behind the Headlines critiques a story that appears in the media. Further information: http://www.nhs.uk/news/2016/04April/Pages/Warning-issued-over-alarming-rise-in-super-gonorrhoea-cases.aspx An inside look into the Clinical Skills Log app Primary Care Today caught up with Andrew Ormerod, research paramedic behind the smart app which allows clinicians to record skills and identify gaps in their practice. News: http://primarycaretoday.co.uk/news/inside-look-clinical-skills-log-app Further information: http://clinicalskillslog.co.uk/ A simple bang on the head can alter a child's relationship with their parents claim academics All mums and dads worry about their children banging their heads in case it causes a serious injury. But such an accident can also harm the bond between parent and child, scientists warn. Around one in 50 under-fives a year suffers concussion, but there has been little research into its effects. Now a study has found it can damage the youngsters’ social interactions – including with their parents. News: http://www.dailymail.co.uk/news/article-3544700/A-simple-bang-head-alter-child-s-relationship-parents-claim-academics.html Abstract: http://onlinelibrary.wiley.com/doi/10.1111/jnp.12104/abstract Behind the Headlines: http://www.nhs.uk/news/2016/04April/Pages/Childs-head-injury-could-damage-child-parent-relationships.aspx Drug Safety Update 2016 Volume: 9 Issue: 9, April Monthly newsletter from the Medicines and Healthcare products Regulatory Agency (MHRA) and its independent advisor the Commission on Human Medicines. Newsletter: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/517251/April_2016.pdf

Double whammy: transitioning from children’s to adult services and transitioning to adulthood Blog from: Marija Trachtenberg, Research Officer, Personal Social Services Research Unit (PSSRU), The London School of Economics and Political Science (LSE). Blog: http://blogs.lse.ac.uk/healthandsocialcare/2016/04/18/double-whammy-transitioning-from-childrens-to-adult-services-and-transitioning-to-adulthood/ Privatisation and independent sector provision of NHS healthcare The BMA surveyed members on their opinions of independent sector provision of NHS healthcare. This report uses these results, as well as data from a number of privatisation indicators, to make eight recommendations regarding independent sector provision of NHS healthcare. Report: http://www.bma.org.uk/-/media/files/pdfs/working%20for%20change/policy%20and%20lobbying/bma-independentsectorprovisionofnhscare-18042016-2.pdf Associated documents: http://www.bma.org.uk/working-for-change/policy-and-lobbying/funding/privatisation-and-independent-sector-providers-in-nhs-care News: http://www.bma.org.uk/news-views-analysis/news/2016/april/bma-report-calls-for-safeguards-against-fragmented-nhs Blog: http://www.bma.org.uk/news-views-analysis/news/2016/april/rescue-bid-for-quality-of-care NHS Partners Network response: http://www.nhsconfed.org/media-centre/2016/04/role-of-the-independent-sector-in-delivering-nhs-care The dogs that don’t bark are the most difficult to hear Blog from: Paul Hodgkin, former GP, founder and current Chair, Patient Opinion. Blog: http://blogs.bmj.com/bmj/2016/04/18/paul-hodgkin-the-dogs-that-dont-bark-are-the-most-difficult-to-hear/ Journal review – 18 April 2016 Blog from: Richard Lehman, GP, Oxfordshire. Blog: http://blogs.bmj.com/bmj/2016/04/18/richard-lehmans-journal-review-18-april-2016/

Low fat diet helps postmenopausal women avoid deadly breast cancers Women who stayed on a low fat diet for approximately eight years reduced their risk of death from invasive breast cancers and improved their survival rates when compared with women who had not

followed the dietary regimen, according to a study presented at a clinical trial plenary session at the American Association for Cancer Research (AACR) annual meeting. News: http://ecancer.org/news/9146-low-fat-diet-helps-postmenopausal-women-avoid-deadly-breast-cancers.php Abstract: http://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=4017&sKey=33e51b6a-c17a-44b4-8d60-181308817ce7&cKey=c6d3e92e-4d28-43c3-ab93-faf799e66c85&mKey=1d10d749-4b6a-4ab3-bcd4-f80fb1922267 NHS should work “hand-in-glove” with housing and care, says health spokesman There is an increasingly urgent need for housing to work more closely with health and social care for the wellbeing of the public, according to Labour’s health spokesman. Further information: http://primarycaretoday.co.uk/news/nhs-should-work-%E2%80%9Chand-glove%E2%80%9D-housing-and-care-says-health-spokesman EVENT: Urgent and emergency care With the urgent care system under pressure and attendances to major A&Es increasing year on year, this King’s Fund conference will demonstrate how to improve the coordination of services and reduce pressure on A&E departments. Further information: http://www.kingsfund.org.uk/events/urgent-and-emergency-care-1 VIDEO: Better Local Care – it’s what we all want isn’t it? This video discusses the Better Local Care initiatives that are taking place in South West New Forest. Video: http://www.fabnhsstuff.net/2016/04/18/better-local-care-its-what-we-all-want-isnt-it/ On the Button Dr Chris Mimnagh, GP, talks about the device that helps to keep him safe in his role as an out of hours GP. Further information: http://www.fabnhsstuff.net/2016/04/18/on-the-button/ Reducing Delayed Transfers of Care in Leicester City By working together, partners in Leicester have been able to more than halve acute delays and reduce all delays significantly over the last year. The key elements of the plan were underpinned by proactive identification and case management in primary care, supported by a new Clinical Response Service, backed up by practical support to manage people through a crisis in their own homes and back into planned, integrated care. Further information: http://www.fabnhsstuff.net/2016/04/19/reducing-delayed-transfers-care-leicester-city/ Quality Outcomes Framework (QOF) Recorded Dementia Diagnoses - March 2016 The Health & Social Care Information Centre (HSCIC) collects data on dementia diagnoses by GPs in support of the national dementia strategy. The data is also used for quality and outcome framework (QOF) reporting and payments. Statistics: http://www.hscic.gov.uk/catalogue/PUB20516 Care Act 2014 Part 1: factsheets (Updated) The Care Act factsheets have been updated to reflect changes made to the Care Act statutory guidance. Factsheets: https://www.gov.uk/government/publications/care-act-2014-part-1-factsheets/care-act-factsheets Associated documents: https://www.gov.uk/government/publications/care-act-2014-part-1-factsheets

GENERAL SURGERY Helping you find the information you need This National Institute for Health and Care Excellence (NICE) blog explains how they have improved their guidance pages to make it easier to find the information you need. Blog: https://www.nice.org.uk/news/blog/helping-you-find-the-information-you-need

HEALTH SERVICES MANAGEMENT Technological advances both threaten our mental health and give us means to improve it Blog from: Craig Thorley, Research Fellow, IPPR. Blog: http://www.ippr.org/blog/technological-advances-both-threaten-our-mental-health-and-give-us-means-to-improve-it Social Prescribing the Vanguard Way Two blogs help to explain what Social Prescribing is by detailing the work being done in the West Wakefield Health and Wellbeing Vanguard. Further information: http://www.fabnhsstuff.net/2016/04/17/theblonde-gets-to-understand-social-prescribing-the-vanguard-way/ Outcomes Focussed Health and WellBeing Service Crossroads are a specialist charitable organisation who provide practical help, support and social opportunities through a variety of projects to carers and those they care for of all ages and disabilities throughout Herefordshire. In October 2015 Herefordshire Council commissioned Crossroads to deliver a new outcomes focused Health and Wellbeing Service to support carers who have been through the Social Care assessment process and been found to have eligible needs. Further information: http://www.fabnhsstuff.net/2016/04/17/outcomes-focussed-health-wellbeing-service/ New Cards proving a good call for Community Midwives When appointments were missed the community maternity team used scraps of paper to write their details on and post through the patients door. As well as not looking professional, they were easy to lose. The team had the idea of implementing “Sorry I missed you” called cards. Further information: http://www.fabnhsstuff.net/2016/04/17/new-cards-proving-a-good-call-for-community-midwives/ Eyes News and Comment from Roy Lilley. Newsletter: http://campaign.r20.constantcontact.com/render?m=1102665899193&ca=95e4df77-bc85-4d43-9d0d-77ac262619d8 Junior doctors contract: Jeremy Hunt's legal power to impose new contract questioned A letter sent by Government lawyers says the Health Secretary is 'introducing' the contract, rather than 'imposing' it upon junior doctors. News: http://www.independent.co.uk/news/uk/politics/junior-doctors-contract-jeremy-hunts-legal-power-to-impose-new-contract-questioned-a6988831.html Suspected and laboratory-confirmed reported norovirus outbreaks in hospitals: outbreaks occurring in weeks 9 to 13, 2016 Week by week reports of suspected and laboratory-confirmed reported norovirus outbreaks in hospitals, with regional breakdown. Latest data: https://www.gov.uk/government/publications/reported-norovirus-outbreaks-in-hospitals-suspected-and-laboratory-confirmed-outbreaks-in-2016/suspected-and-laboratory-confirmed-reported-norovirus-outbreaks-in-hospitals-outbreaks-occurring-in-weeks-9-to-13-2016 Previous data: https://www.gov.uk/government/publications/reported-norovirus-outbreaks-in-hospitals-suspected-and-laboratory-confirmed-outbreaks-in-2016 Top 10 Patient Safety Concerns for Healthcare Organisations 2016 Patient safety is a top priority for every healthcare organization, but knowing where to direct initiatives can be daunting. To help organizations decide where to focus their efforts, ECRI Institute has compiled its third annual list of the Top 10 Patient Safety Concerns for Healthcare Organizations. Health IT, Patient Identification, and Behavioral Health Issues are the issues that top the list this year. NB Free registration is required to access this document. Document: https://www.ecri.org/Pages/Top-10-Patient-Safety-Concerns.aspx Press release: https://www.ecri.org/press/Pages/Health-IT-Patient-Identification-Behavioral-Health-2016-Top-10-Patient-Safety-Concerns.aspx Helping you find the information you need This National Institute for Health and Care Excellence (NICE) blog explains how they have improved their guidance pages to make it easier to find the information you need.

Blog: https://www.nice.org.uk/news/blog/helping-you-find-the-information-you-need Organisation Patient Safety Incident Reports - data workbooks April 2016 These data workbooks cover organisation patient safety incident reports data for incidents that occurred between 1 April 2015 and 30 September 2015 and were reported to the National Reporting and Learning System by 30 November 2015. Data: http://www.nrls.npsa.nhs.uk/resources/?EntryId45=135586 Supporting information: http://www.nrls.npsa.nhs.uk/resources/?EntryId45=135546 Statement on junior doctors' dispute The Royal College of Anaesthetists (RCoA) has made a statement regarding the escalation of the dispute. Statement: http://www.rcoa.ac.uk/news-and-bulletin/rcoa-news-and-statements/statement-junior-doctors-dispute Statesmanship among medical leaders could help resolve the junior doctors’ dispute Blog from: Chris Ham, Chief Executive, The King’s Fund. Blog: http://www.kingsfund.org.uk/blog/2016/04/junior-doctors-contract-dispute Urgent Question on imposition of new junior doctor contract Secretary of State for Health, Jeremy Hunt, responded to an Urgent Question asked by Shadow Secretary of State for Health, Heidi Alexander, in the House of Commons on the imposition of a new junior doctor contract. Further information: http://www.parliament.uk/business/news/2016/april/urgent-question-on-imposition-of-new-junior-doctor-contract/ Double whammy: transitioning from children’s to adult services and transitioning to adulthood Blog from: Marija Trachtenberg, Research Officer, Personal Social Services Research Unit (PSSRU), The London School of Economics and Political Science (LSE). Blog: http://blogs.lse.ac.uk/healthandsocialcare/2016/04/18/double-whammy-transitioning-from-childrens-to-adult-services-and-transitioning-to-adulthood/ Privatisation and independent sector provision of NHS healthcare The BMA surveyed members on their opinions of independent sector provision of NHS healthcare. This report uses these results, as well as data from a number of privatisation indicators, to make eight recommendations regarding independent sector provision of NHS healthcare. Report: http://www.bma.org.uk/-/media/files/pdfs/working%20for%20change/policy%20and%20lobbying/bma-independentsectorprovisionofnhscare-18042016-2.pdf Associated documents: http://www.bma.org.uk/working-for-change/policy-and-lobbying/funding/privatisation-and-independent-sector-providers-in-nhs-care News: http://www.bma.org.uk/news-views-analysis/news/2016/april/bma-report-calls-for-safeguards-against-fragmented-nhs Blog: http://www.bma.org.uk/news-views-analysis/news/2016/april/rescue-bid-for-quality-of-care NHS Partners Network response: http://www.nhsconfed.org/media-centre/2016/04/role-of-the-independent-sector-in-delivering-nhs-care The dogs that don’t bark are the most difficult to hear Blog from: Paul Hodgkin, former GP, founder and current Chair, Patient Opinion. Blog: http://blogs.bmj.com/bmj/2016/04/18/paul-hodgkin-the-dogs-that-dont-bark-are-the-most-difficult-to-hear/ NHS should work “hand-in-glove” with housing and care, says health spokesman There is an increasingly urgent need for housing to work more closely with health and social care for the wellbeing of the public, according to Labour’s health spokesman. Further information: http://primarycaretoday.co.uk/news/nhs-should-work-%E2%80%9Chand-glove%E2%80%9D-housing-and-care-says-health-spokesman EVENT: Urgent and emergency care With the urgent care system under pressure and attendances to major A&Es increasing year on year, this King’s Fund conference will demonstrate how to improve the coordination of services and reduce pressure on A&E departments.

Further information: http://www.kingsfund.org.uk/events/urgent-and-emergency-care-1 NHS Workforce Bulletin Issue 513, 18 April 2016 Tips, tools, guidance and information on NHS workforce issues from NHS Employers. Bulletin: http://www.nhsemployers.org/?sc_itemid={AE0224EE-48A0-4BE5-9FFB-D38C3EC18AC8}&sc_lang=en&sc_pd_view=1&ec_as=27522B58FF06401C81A88637F353081D LEAD-it Leicester Emergency Advancement and Development of International Training Like innumerable other emergency departments (ED) in the UK, Leicester faced difficulties with recruitment and retention of medical staff at all levels. The delivery of international recruitment by a core team concentrating on processes of recruitment, support, training and integration of this staff group into the workforce and the retention of junior grade doctors however has achieved key outcomes including the reduction in the number of vacant training/trust posts and the reduction in temporary staff usage, lowering premium spend. Further information: http://www.fabnhsstuff.net/2016/04/16/lead-leicester-emergency-advancement-development-international-training/ VIDEO: Better Local Care – it’s what we all want isn’t it? This video discusses the Better Local Care initiatives that are taking place in South West New Forest. Video: http://www.fabnhsstuff.net/2016/04/18/better-local-care-its-what-we-all-want-isnt-it/ On the Button Dr Chris Mimnagh, GP, talks about the device that helps to keep him safe in his role as an out of hours GP. Further information: http://www.fabnhsstuff.net/2016/04/18/on-the-button/ Stepping Stones News and Comment from Roy Lilley. Newsletter: http://campaign.r20.constantcontact.com/render?m=1102665899193&ca=a03bde58-5322-4085-8a75-88562eaad28f Reducing Delayed Transfers of Care in Leicester City By working together, partners in Leicester have been able to more than halve acute delays and reduce all delays significantly over the last year. The key elements of the plan were underpinned by proactive identification and case management in primary care, supported by a new Clinical Response Service, backed up by practical support to manage people through a crisis in their own homes and back into planned, integrated care. Further information: http://www.fabnhsstuff.net/2016/04/19/reducing-delayed-transfers-care-leicester-city/ NHS bullying made me want to kill myself and forced me to quit A former NHS employee tells their story in the form of an anonymous blog. Blog: http://www.theguardian.com/healthcare-network/views-from-the-nhs-frontline/2016/apr/18/nhs-bullying-made-me-want-kill-myself-forced-quit Learning Disability Services Monthly Statistics - England Commissioner Census (Assuring Transformation) - March 2016, Experimental Statistics This statistical release makes available the most recent data relating to patients with learning disabilities and/or autism spectrum disorder receiving inpatient care commissioned in England. Statistics: http://www.hscic.gov.uk/catalogue/PUB20499 Care Act 2014 Part 1: factsheets (Updated) The Care Act factsheets have been updated to reflect changes made to the Care Act statutory guidance. Factsheets: https://www.gov.uk/government/publications/care-act-2014-part-1-factsheets/care-act-factsheets Associated documents: https://www.gov.uk/government/publications/care-act-2014-part-1-factsheets

IMMUNISATION New human papillomavirus (HPV) vaccine could curb cervical cancers and health costs if adopted widely A Yale-led study finds that a new vaccine for human papillomavirus (HPV) would significantly reduce both cervical cancer incidence and healthcare costs if states coordinated policies to improve coverage. News: http://ecancer.org/news/9117-new-hpv-vaccine-could-curb-cervical-cancers-and-health-costs-if-adopted-widely.php Abstract: http://www.pnas.org/content/early/2016/04/13/1515528113.abstract Vaccine update: issue 244, April 2016, BCG supply special edition This special edition of vaccine update features information on the central supply of the BCG vaccine and advice on prioritisation of local BCG vaccine stock. Bulletin: https://www.gov.uk/government/publications/vaccine-update-issue-244-april-2016-bcg-supply-special-edition

INFECTION CONTROL AND INFECTIOUS DISEASES Notifications of Infection Diseases (NOIDs) causative agents: week 15 (week ending 17 April 2016) Weekly data from UK laboratories on the number of cases of notifiable bacteria and viruses. It compares the current week’s data on statutory notifications of causative agents to that of the previous 5 weeks. Latest data: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/517191/NOIDS_OrganismsReport18042016.pdf Previous data: https://www.gov.uk/government/publications/notifiable-diseases-causative-agents-report Suspected and laboratory-confirmed reported norovirus outbreaks in hospitals: outbreaks occurring in weeks 9 to 13, 2016 Week by week reports of suspected and laboratory-confirmed reported norovirus outbreaks in hospitals, with regional breakdown. Latest data: https://www.gov.uk/government/publications/reported-norovirus-outbreaks-in-hospitals-suspected-and-laboratory-confirmed-outbreaks-in-2016/suspected-and-laboratory-confirmed-reported-norovirus-outbreaks-in-hospitals-outbreaks-occurring-in-weeks-9-to-13-2016 Previous data: https://www.gov.uk/government/publications/reported-norovirus-outbreaks-in-hospitals-suspected-and-laboratory-confirmed-outbreaks-in-2016 Salmonella infections (faecal specimens) England and Wales, laboratory reports (Public Health England (PHE) salmonella data set): Feb-Mar 2016 Monthly laboratory reports of cases by salmonella serotype, from the Public Health England salmonella data set. Latest data: https://www.gov.uk/government/publications/salmonella-infections-faecal-specimens-in-england-and-wales-laboratory-reports-2016/salmonella-infections-faecal-specimens-england-and-wales-laboratory-reports-phe-salmonella-data-set-feb-mar-2016 Previous data: https://www.gov.uk/government/publications/salmonella-infections-faecal-specimens-in-england-and-wales-laboratory-reports-2016 Common gastrointestinal infections, England and Wales: laboratory reports weeks 9 to 13, 2016 Monthly reports of lab-confirmed common enteric infections, with weekly and cumulative totals, in 2016. Latest data: https://www.gov.uk/government/publications/common-gastrointestinal-infections-in-england-and-wales-laboratory-reports-in-2016/common-gastrointestinal-infections-england-and-wales-laboratory-reports-weeks-9-to-13-2016 Previous data: https://www.gov.uk/government/publications/common-gastrointestinal-infections-in-england-and-wales-laboratory-reports-in-2016 Outbreak of high level azithromycin resistant gonorrhoea in England Microbiological and epidemiological information related to an outbreak diagnosed amongst residents of England since November 2015.

Report: https://www.gov.uk/government/publications/high-level-azithromycin-resistant-gonorrhoea-in-england New human papillomavirus (HPV) vaccine could curb cervical cancers and health costs if adopted widely A Yale-led study finds that a new vaccine for human papillomavirus (HPV) would significantly reduce both cervical cancer incidence and healthcare costs if states coordinated policies to improve coverage. News: http://ecancer.org/news/9117-new-hpv-vaccine-could-curb-cervical-cancers-and-health-costs-if-adopted-widely.php Abstract: http://www.pnas.org/content/early/2016/04/13/1515528113.abstract Warning issued over alarming rise in 'super-gonorrhoea' cases Behind the Headlines critiques a story that appears in the media. Further information: http://www.nhs.uk/news/2016/04April/Pages/Warning-issued-over-alarming-rise-in-super-gonorrhoea-cases.aspx Public health laboratory Manchester: request form (Updated) This request form has been updated. Document: https://www.gov.uk/government/publications/public-health-laboratory-manchester-request-form

INFORMATICS AND INFORMATION GOVERNANCE How to improve your patient’s understanding of consent and data protection In response to the need for improved communication with patients, ecancer and the Institute for Legal Informatics in Hannover have created four educational videos on medical data protection. To make the information accessible for patients, the videos have also been turned into four e-learning modules. Further information: http://ecancer.org/news/9152-how-to-improve-your-patient---s-understanding-of-consent-and-data-protection.php On the Button Dr Chris Mimnagh, GP, talks about the device that helps to keep him safe in his role as an out of hours GP. Further information: http://www.fabnhsstuff.net/2016/04/18/on-the-button/

LEARNING DISABILITIES Learning Disability Services Monthly Statistics - England Commissioner Census (Assuring Transformation) - March 2016, Experimental Statistics This statistical release makes available the most recent data relating to patients with learning disabilities and/or autism spectrum disorder receiving inpatient care commissioned in England. Statistics: http://www.hscic.gov.uk/catalogue/PUB20499

MATERNITY & GYNAECOLOGY New Cards proving a good call for Community Midwives When appointments were missed the community maternity team used scraps of paper to write their details on and post through the patients door. As well as not looking professional, they were easy to lose. The team had the idea of implementing “Sorry I missed you” called cards. Further information: http://www.fabnhsstuff.net/2016/04/17/new-cards-proving-a-good-call-for-community-midwives/

MEDICINES MANAGEMENT/PHARMACY Hints & Tips – Dispensing Contractors: Issue 23 Latest issue. Bulletin: http://www.nhsbsa.nhs.uk/Documents/PrescriptionServices/Dispensing_Contractors_-_Issue_23_(V1).pdf

Shaping the Research Agenda to Estimate Relevant Cost-effectiveness Thresholds for Health Technology Assessment Decision Making: Report for Association of the British Pharmaceutical Industry (ABPI) This Office of Health Economics (OHE) consulting report details the views of a selection of experts in the fields of health and welfare economics on the cost-effectiveness threshold used by the National Institute for Health and Care Excellence (NICE) to decide which new medicines to recommend for use in the NHS, and the direction of future research in this area. Report: https://www.ohe.org/publications/shaping-research-agenda-estimate-cost-effectiveness-thresholds-decision-making News: https://www.ohe.org/news/new-ohe-consulting-report-shaping-research-agenda-estimate-cost-effectiveness-thresholds Drug Safety Update 2016 Volume: 9 Issue: 9, April Monthly newsletter from the Medicines and Healthcare products Regulatory Agency (MHRA) and its independent advisor the Commission on Human Medicines. Newsletter: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/517251/April_2016.pdf Pharmaceutical Services Negotiating Committee (PSNC) Briefing 024/16: Reporting Electronic Prescription Service (EPS) issues This one page briefing contains a quick reference guide to reporting EPS issues. Briefing: http://psnc.org.uk/wp-content/uploads/2013/04/PSNC-Briefing-024.16-Reporting-EPS-issues.pdf

MENTAL HEALTH AND WELLBEING Technological advances both threaten our mental health and give us means to improve it Blog from: Craig Thorley, Research Fellow, IPPR. Blog: http://www.ippr.org/blog/technological-advances-both-threaten-our-mental-health-and-give-us-means-to-improve-it Protein injection hope for Alzheimer's Scientists believe injections of a natural protein may lessen the symptoms and progress of Alzheimer's dementia after promising early trials in mice. The treatment - IL 33 - appeared to improve memory and help clear and prevent brain deposits similar to those seen in people with Alzheimer's. News: http://www.bbc.co.uk/news/health-36070987 Abstract: http://www.pnas.org/content/early/2016/04/13/1604032113.abstract Article (PDF): http://www.pnas.org/content/early/2016/04/13/1604032113.full.pdf?with-ds=yes Expert reaction: http://www.sciencemediacentre.org/expert-reaction-to-il-33-protein-for-dementia-in-mice/ A simple bang on the head can alter a child's relationship with their parents claim academics All mums and dads worry about their children banging their heads in case it causes a serious injury. But such an accident can also harm the bond between parent and child, scientists warn. Around one in 50 under-fives a year suffers concussion, but there has been little research into its effects. Now a study has found it can damage the youngsters’ social interactions – including with their parents. News: http://www.dailymail.co.uk/news/article-3544700/A-simple-bang-head-alter-child-s-relationship-parents-claim-academics.html Abstract: http://onlinelibrary.wiley.com/doi/10.1111/jnp.12104/abstract Behind the Headlines: http://www.nhs.uk/news/2016/04April/Pages/Childs-head-injury-could-damage-child-parent-relationships.aspx Quality Outcomes Framework (QOF) Recorded Dementia Diagnoses - March 2016 The Health & Social Care Information Centre (HSCIC) collects data on dementia diagnoses by GPs in support of the national dementia strategy. The data is also used for quality and outcome framework (QOF) reporting and payments. Statistics: http://www.hscic.gov.uk/catalogue/PUB20516

NEUROLOGY Protein injection hope for Alzheimer's Scientists believe injections of a natural protein may lessen the symptoms and progress of Alzheimer's dementia after promising early trials in mice. The treatment - IL 33 - appeared to improve memory and help clear and prevent brain deposits similar to those seen in people with Alzheimer's. News: http://www.bbc.co.uk/news/health-36070987 Abstract: http://www.pnas.org/content/early/2016/04/13/1604032113.abstract Article (PDF): http://www.pnas.org/content/early/2016/04/13/1604032113.full.pdf?with-ds=yes Expert reaction: http://www.sciencemediacentre.org/expert-reaction-to-il-33-protein-for-dementia-in-mice/ A simple bang on the head can alter a child's relationship with their parents claim academics All mums and dads worry about their children banging their heads in case it causes a serious injury. But such an accident can also harm the bond between parent and child, scientists warn. Around one in 50 under-fives a year suffers concussion, but there has been little research into its effects. Now a study has found it can damage the youngsters’ social interactions – including with their parents. News: http://www.dailymail.co.uk/news/article-3544700/A-simple-bang-head-alter-child-s-relationship-parents-claim-academics.html Abstract: http://onlinelibrary.wiley.com/doi/10.1111/jnp.12104/abstract Behind the Headlines: http://www.nhs.uk/news/2016/04April/Pages/Childs-head-injury-could-damage-child-parent-relationships.aspx

NURSING PRACTICE Helping you find the information you need This National Institute for Health and Care Excellence (NICE) blog explains how they have improved their guidance pages to make it easier to find the information you need. Blog: https://www.nice.org.uk/news/blog/helping-you-find-the-information-you-need Uniting Children’s Community Nurses Together Becky Hepworth, Community Children's Nurse Team Leader, Isle of Wight NHS Trust explains how she uses Twitter to connect with other Community Children's Nurses. Further information: http://www.fabnhsstuff.net/2016/04/18/uniting-childrens-community-nurses-together/

OPHTHALMOLOGY Combination therapy may offer better outcomes for patients with retinoblastoma Researchers have demonstrated that targeting survivin - a protein that inhibits apoptosis or cell death - enhances the effectiveness of chemotherapy in cells and mouse models of retinoblastoma (Rb), the most common malignant tumour of the eye in children. News: http://ecancer.org/news/9151-combination-therapy-may-offer-better-outcomes-for-patients-with-retinoblastoma.php Article: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153011

ORTHOPAEDICS The trauma of too much information Blog from: Jon Holley, CT2 Doctor Trauma & Orthopaedics and National Medical Director’s Fellow, National Institute for Health and Care Excellence (NICE). Blog: https://www.nice.org.uk/news/blog/the-trauma-of-too-much-information

PALLIATIVE CARE EVENT: Talking about Sex, Sexuality and Relationships: Translating the Standards and Guidance into Practice This (free of charge) Masterclass aims to provide greater understanding and awareness of the needs of young people with life-limiting or life-threatening conditions in relation to sex, sexuality and relationships.

Further information: https://www2.togetherforshortlives.org.uk/portal/public/event/eventBooking.aspx?id=EVT00336 #CPCDialog discusses children’s palliative care at an international level The International Children’s Palliative Care Network (ICPCN) to host their next #CPCDialog tweetchat on ‘children’s palliative care at an international level.’ Further information: http://www.ehospice.com/articleview/tabid/10686/articleid/19027/language/en-gb/-cpcdialog-discusses-children-s-palliative-care-at-an-international-level.aspx?utm_campaign=website&utm_source=sendgrid.com&utm_medium=email

PATHOLOGY Interim guidance: handling and processing of specimens associated with Middle East respiratory syndrome coronavirus (MERS-CoV) in clinical diagnostic laboratories Knowledge about the pathogenic potential and transmission risks for MERS-CoV is incomplete and continues to evolve. This interim guidance is based on current knowledge and aims to minimise risks for laboratory staff handling specimens from patients with suspected or laboratory-confirmed MERS-CoV infection. Guidance: https://www.gov.uk/government/publications/mers-cov-clinical-diagnostic-laboratory-specimen-handling-and-processing Notifications of Infection Diseases (NOIDs) causative agents: week 15 (week ending 17 April 2016) Weekly data from UK laboratories on the number of cases of notifiable bacteria and viruses. It compares the current week’s data on statutory notifications of causative agents to that of the previous 5 weeks. Latest data: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/517191/NOIDS_OrganismsReport18042016.pdf Previous data: https://www.gov.uk/government/publications/notifiable-diseases-causative-agents-report Suspected and laboratory-confirmed reported norovirus outbreaks in hospitals: outbreaks occurring in weeks 9 to 13, 2016 Week by week reports of suspected and laboratory-confirmed reported norovirus outbreaks in hospitals, with regional breakdown. Latest data: https://www.gov.uk/government/publications/reported-norovirus-outbreaks-in-hospitals-suspected-and-laboratory-confirmed-outbreaks-in-2016/suspected-and-laboratory-confirmed-reported-norovirus-outbreaks-in-hospitals-outbreaks-occurring-in-weeks-9-to-13-2016 Previous data: https://www.gov.uk/government/publications/reported-norovirus-outbreaks-in-hospitals-suspected-and-laboratory-confirmed-outbreaks-in-2016 Salmonella infections (faecal specimens) England and Wales, laboratory reports (Public Health England (PHE) salmonella data set): Feb-Mar 2016 Monthly laboratory reports of cases by salmonella serotype, from the Public Health England salmonella data set. Latest data: https://www.gov.uk/government/publications/salmonella-infections-faecal-specimens-in-england-and-wales-laboratory-reports-2016/salmonella-infections-faecal-specimens-england-and-wales-laboratory-reports-phe-salmonella-data-set-feb-mar-2016 Previous data: https://www.gov.uk/government/publications/salmonella-infections-faecal-specimens-in-england-and-wales-laboratory-reports-2016 Common gastrointestinal infections, England and Wales: laboratory reports weeks 9 to 13, 2016 Monthly reports of lab-confirmed common enteric infections, with weekly and cumulative totals, in 2016. Latest data: https://www.gov.uk/government/publications/common-gastrointestinal-infections-in-england-and-wales-laboratory-reports-in-2016/common-gastrointestinal-infections-england-and-wales-laboratory-reports-weeks-9-to-13-2016 Previous data: https://www.gov.uk/government/publications/common-gastrointestinal-infections-in-england-and-wales-laboratory-reports-in-2016

Outbreak of high level azithromycin resistant gonorrhoea in England Microbiological and epidemiological information related to an outbreak diagnosed amongst residents of England since November 2015. Report: https://www.gov.uk/government/publications/high-level-azithromycin-resistant-gonorrhoea-in-england Protein injection hope for Alzheimer's Scientists believe injections of a natural protein may lessen the symptoms and progress of Alzheimer's dementia after promising early trials in mice. The treatment - IL 33 - appeared to improve memory and help clear and prevent brain deposits similar to those seen in people with Alzheimer's. News: http://www.bbc.co.uk/news/health-36070987 Abstract: http://www.pnas.org/content/early/2016/04/13/1604032113.abstract Article (PDF): http://www.pnas.org/content/early/2016/04/13/1604032113.full.pdf?with-ds=yes Expert reaction: http://www.sciencemediacentre.org/expert-reaction-to-il-33-protein-for-dementia-in-mice/ AACR 2016: Results from clinical trial of personalised cellular therapy in brain tumours Immune cells engineered to seek out and attack a type of deadly brain cancer known as glioblastoma (GBM) were found to have an acceptable safety profile and successfully migrate to and infiltrate tumours, researchers from Penn Medicine and Harvard University reported at the American Association for Cancer Research (AACR) Annual Meeting 2016. News: http://ecancer.org/news/9143-aacr-2016--results-from-clinical-trial-of-personalised-cellular-therapy-in-brain-tumours.php Abstract: http://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=4017&sKey=826269b3-49e3-449d-b2cc-5a95aafb9aa4&cKey=73dbe411-6dcf-4d29-9e93-22c94c393587&mKey=1d10d749-4b6a-4ab3-bcd4-f80fb1922267 Metastasis-promoting circulating tumour cell clusters pass through capillary-sized vessels Investigators have found that circulating tumour cell (CTC) clusters - which are more efficient in spreading cancer throughout the body than are single CTCs - can pass through capillary-sized blood vessels. Their findings, which contradict the widely-held belief that CTC clusters are too large to pass through capillaries, suggest potential strategies to reduce clusters' metastatic potential. News: http://ecancer.org/news/9142-metastasis-promoting-circulating-tumour-cell-clusters-pass-through-capillary-sized-vessels.php Abstract: http://www.pnas.org/content/early/2016/04/13/1524448113.abstract Article (PDF): http://www.pnas.org/content/early/2016/04/13/1524448113.full.pdf?with-ds=yes Warning issued over alarming rise in 'super-gonorrhoea' cases Behind the Headlines critiques a story that appears in the media. Further information: http://www.nhs.uk/news/2016/04April/Pages/Warning-issued-over-alarming-rise-in-super-gonorrhoea-cases.aspx Researchers identify enzyme link between excessive heart muscle growth, cancer growth University of Texas (UT) Southwestern Medical Center cardiology researchers have identified molecular ties between the growth of cancer cells and heart cells that suggest existing cancer drugs may be able to help those with enlarged heart cells -- a condition that can lead to heart attacks and stroke. News: http://www.utsouthwestern.edu/newsroom/news-releases/year-2016/april/cardiac-hypertrophy-hill.html Abstract: http://stke.sciencemag.org/content/9/422/ra34.abstract Public health laboratory Manchester: request form (Updated) This request form has been updated. Document: https://www.gov.uk/government/publications/public-health-laboratory-manchester-request-form

PATIENT SAFETY Top 10 Patient Safety Concerns for Healthcare Organisations 2016 Patient safety is a top priority for every healthcare organization, but knowing where to direct initiatives can be daunting. To help organizations decide where to focus their efforts, ECRI Institute

has compiled its third annual list of the Top 10 Patient Safety Concerns for Healthcare Organizations. Health IT, Patient Identification, and Behavioral Health Issues are the issues that top the list this year. NB Free registration is required to access this document. Document: https://www.ecri.org/Pages/Top-10-Patient-Safety-Concerns.aspx Press release: https://www.ecri.org/press/Pages/Health-IT-Patient-Identification-Behavioral-Health-2016-Top-10-Patient-Safety-Concerns.aspx Organisation Patient Safety Incident Reports - data workbooks April 2016 These data workbooks cover organisation patient safety incident reports data for incidents that occurred between 1 April 2015 and 30 September 2015 and were reported to the National Reporting and Learning System by 30 November 2015. Data: http://www.nrls.npsa.nhs.uk/resources/?EntryId45=135586 Supporting information: http://www.nrls.npsa.nhs.uk/resources/?EntryId45=135546

PUBLIC HEALTH/HEALTH IMPROVEMENT Notifications of Infection Diseases (NOIDs) causative agents: week 15 (week ending 17 April 2016) Weekly data from UK laboratories on the number of cases of notifiable bacteria and viruses. It compares the current week’s data on statutory notifications of causative agents to that of the previous 5 weeks. Latest data: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/517191/NOIDS_OrganismsReport18042016.pdf Previous data: https://www.gov.uk/government/publications/notifiable-diseases-causative-agents-report Suspected and laboratory-confirmed reported norovirus outbreaks in hospitals: outbreaks occurring in weeks 9 to 13, 2016 Week by week reports of suspected and laboratory-confirmed reported norovirus outbreaks in hospitals, with regional breakdown. Latest data: https://www.gov.uk/government/publications/reported-norovirus-outbreaks-in-hospitals-suspected-and-laboratory-confirmed-outbreaks-in-2016/suspected-and-laboratory-confirmed-reported-norovirus-outbreaks-in-hospitals-outbreaks-occurring-in-weeks-9-to-13-2016 Previous data: https://www.gov.uk/government/publications/reported-norovirus-outbreaks-in-hospitals-suspected-and-laboratory-confirmed-outbreaks-in-2016 Salmonella infections (faecal specimens) England and Wales, laboratory reports (Public Health England (PHE) salmonella data set): Feb-Mar 2016 Monthly laboratory reports of cases by salmonella serotype, from the Public Health England salmonella data set. Latest data: https://www.gov.uk/government/publications/salmonella-infections-faecal-specimens-in-england-and-wales-laboratory-reports-2016/salmonella-infections-faecal-specimens-england-and-wales-laboratory-reports-phe-salmonella-data-set-feb-mar-2016 Previous data: https://www.gov.uk/government/publications/salmonella-infections-faecal-specimens-in-england-and-wales-laboratory-reports-2016 Common gastrointestinal infections, England and Wales: laboratory reports weeks 9 to 13, 2016 Monthly reports of lab-confirmed common enteric infections, with weekly and cumulative totals, in 2016. Latest data: https://www.gov.uk/government/publications/common-gastrointestinal-infections-in-england-and-wales-laboratory-reports-in-2016/common-gastrointestinal-infections-england-and-wales-laboratory-reports-weeks-9-to-13-2016 Previous data: https://www.gov.uk/government/publications/common-gastrointestinal-infections-in-england-and-wales-laboratory-reports-in-2016 Outbreak of high level azithromycin resistant gonorrhoea in England Microbiological and epidemiological information related to an outbreak diagnosed amongst residents of England since November 2015.

Report: https://www.gov.uk/government/publications/high-level-azithromycin-resistant-gonorrhoea-in-england Helping you find the information you need This National Institute for Health and Care Excellence (NICE) blog explains how they have improved their guidance pages to make it easier to find the information you need. Blog: https://www.nice.org.uk/news/blog/helping-you-find-the-information-you-need AACR 2016: Physical activity may improve prostate cancer prognosis Prostate cancer patients and survivors who maintain a moderate to high level of physical activity may improve their survival prognosis, according to research presented at the American Association for Cancer Research (AACR) Annual Meeting 2016. News: http://ecancer.org/news/9071-aacr-2016--physical-activity-may-improve-prostate-cancer-prognosis.php Abstract: http://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=4017&sKey=d33d7049-eb65-4cf1-8d47-1eb572294216&cKey=4fd07bf1-c184-4c6b-aeba-081fe4de992b&mKey=1d10d749-4b6a-4ab3-bcd4-f80fb1922267

New human papillomavirus (HPV) vaccine could curb cervical cancers and health costs if adopted widely A Yale-led study finds that a new vaccine for human papillomavirus (HPV) would significantly reduce both cervical cancer incidence and healthcare costs if states coordinated policies to improve coverage. News: http://ecancer.org/news/9117-new-hpv-vaccine-could-curb-cervical-cancers-and-health-costs-if-adopted-widely.php Abstract: http://www.pnas.org/content/early/2016/04/13/1515528113.abstract

Warning issued over alarming rise in 'super-gonorrhoea' cases Behind the Headlines critiques a story that appears in the media. Further information: http://www.nhs.uk/news/2016/04April/Pages/Warning-issued-over-alarming-rise-in-super-gonorrhoea-cases.aspx Researching alcohol harm: 30 years of impact Alcohol Research UK commissioned a project to examine the impact that its research has had. This report summarises some of the key data and case studies from the project. Report: http://alcoholresearchuk.org/special-reports/alcohol-research-uk-has-published-a-report-which-looks-back-at-its-30-year-history/ Low fat diet helps postmenopausal women avoid deadly breast cancers Women who stayed on a low fat diet for approximately eight years reduced their risk of death from invasive breast cancers and improved their survival rates when compared with women who had not followed the dietary regimen, according to a study presented at a clinical trial plenary session at the American Association for Cancer Research (AACR) annual meeting. News: http://ecancer.org/news/9146-low-fat-diet-helps-postmenopausal-women-avoid-deadly-breast-cancers.php Abstract: http://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=4017&sKey=33e51b6a-c17a-44b4-8d60-181308817ce7&cKey=c6d3e92e-4d28-43c3-ab93-faf799e66c85&mKey=1d10d749-4b6a-4ab3-bcd4-f80fb1922267 NHS should work “hand-in-glove” with housing and care, says health spokesman There is an increasingly urgent need for housing to work more closely with health and social care for the wellbeing of the public, according to Labour’s health spokesman. Further information: http://primarycaretoday.co.uk/news/nhs-should-work-%E2%80%9Chand-glove%E2%80%9D-housing-and-care-says-health-spokesman UK Biobank study identifies gene changes that influence timing of sexual behaviour A study of over 380,000 people, published today in the journal Nature Genetics, has identified gene differences that influence the age of puberty, sexual intercourse and first birth. Age at first sexual intercourse is known to be influenced by social and family factors, such as peer pressure, but this study shows that genetic factors also have an influence on the timing of this sexual behaviour. It is known from other studies that first sexual intercourse at an early age is associated with adverse educational achievements, physical health and mental wellbeing.

News: http://www.mrc.ac.uk/news/browse/uk-biobank-study-identifies-gene-changes-that-influence-timing-of-sexual-behaviour/ Abstract: http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3551.html Further information: http://www.mrc-epid.cam.ac.uk/blog/biobank-genes-age-first-sex-the-conversation/ Deaths registered in England and Wales, weekly provisional: ending 8 April 2016 Weekly death figures provide provisional counts of the number of deaths registered in England and Wales in the latest weeks for which data are available. Statistics: https://www.ons.gov.uk/releases/deathsregisteredinenglandandwalesweeklyprovisionalending8april2016 Birth cohort tables for infant deaths, England and Wales: 2013 Infant deaths figures reported in these tables represent babies born in 2013 who died before their first birthday: the 2013 birth cohort for infant deaths. This includes babies who died either in 2013 or in 2014 and were under 1 year of age. Statistics: https://www.ons.gov.uk/releases/birthcohorttablesforinfantdeathsenglandandwales2013 Child mortality in England and Wales: 2014 This bulletin presents final statistics on infant deaths and childhood deaths that occurred in England and Wales in 2014. It also contains additional statistics on some of the main risk factors affecting infant deaths, including age of mother and birthweight. Statistics: https://www.ons.gov.uk/releases/childmortalityinenglandandwales2014 Care Act 2014 Part 1: factsheets (Updated) The Care Act factsheets have been updated to reflect changes made to the Care Act statutory guidance. Factsheets: https://www.gov.uk/government/publications/care-act-2014-part-1-factsheets/care-act-factsheets Associated documents: https://www.gov.uk/government/publications/care-act-2014-part-1-factsheets Public health laboratory Manchester: request form (Updated) This request form has been updated. Document: https://www.gov.uk/government/publications/public-health-laboratory-manchester-request-form

RADIOLOGY Comparative Effectiveness Review number 174: Imaging for the Pretreatment Staging of Small Cell Lung Cancer This review found evidence is sparse on imaging modalities in the pretreatment staging of small cell lung cancer. However the authors managed to draw three conclusions about comparative accuracy: (1) Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is more sensitive than multidetector computed tomography (MDCT) for detecting osseous metastases; (2) FDG PET/CT is more sensitive than bone scintigraphy for detecting osseous metastases; (3) Standard staging plus FDG PET/CT is more sensitive than standard staging alone for detecting any distant metastases. Systematic review: https://www.effectivehealthcare.ahrq.gov/ehc/products/595/2211/lung-cancer-staging-report-160414.pdf

RESEARCH Shaping the Research Agenda to Estimate Relevant Cost-effectiveness Thresholds for Health Technology Assessment Decision Making: Report for Association of the British Pharmaceutical Industry (ABPI) This Office of Health Economics (OHE) consulting report details the views of a selection of experts in the fields of health and welfare economics on the cost-effectiveness threshold used by the National Institute for Health and Care Excellence (NICE) to decide which new medicines to recommend for use in the NHS, and the direction of future research in this area.

Report: https://www.ohe.org/publications/shaping-research-agenda-estimate-cost-effectiveness-thresholds-decision-making News: https://www.ohe.org/news/new-ohe-consulting-report-shaping-research-agenda-estimate-cost-effectiveness-thresholds

RESPIRATORY Transforming the care of children and young people in the capital with asthma Healthy London Partnership is a collaboration between London’s 32 clinical commissioning groups (CCGs) and NHS England London region to support better health for London. A group of leading clinicians and commissioners from across the capital were brought together to develop a set of standards for care of children and young people with asthma and pre-school/viral induced wheeze to complement the existing London Quality Standards, Primary Care Commissioning Framework and Children and Young People’s Acute Care Standards. Further information: http://www.fabnhsstuff.net/2016/04/17/transforming-care-children-young-people-capital-asthma/

SEXUAL HEALTH EVENT: Talking about Sex, Sexuality and Relationships: Translating the Standards and Guidance into Practice This (free of charge) Masterclass aims to provide greater understanding and awareness of the needs of young people with life-limiting or life-threatening conditions in relation to sex, sexuality and relationships. Further information: https://www2.togetherforshortlives.org.uk/portal/public/event/eventBooking.aspx?id=EVT00336 Outbreak of high level azithromycin resistant gonorrhoea in England Microbiological and epidemiological information related to an outbreak diagnosed amongst residents of England since November 2015. Report: https://www.gov.uk/government/publications/high-level-azithromycin-resistant-gonorrhoea-in-england New human papillomavirus (HPV) vaccine could curb cervical cancers and health costs if adopted widely A Yale-led study finds that a new vaccine for human papillomavirus (HPV) would significantly reduce both cervical cancer incidence and healthcare costs if states coordinated policies to improve coverage. News: http://ecancer.org/news/9117-new-hpv-vaccine-could-curb-cervical-cancers-and-health-costs-if-adopted-widely.php Abstract: http://www.pnas.org/content/early/2016/04/13/1515528113.abstract Warning issued over alarming rise in 'super-gonorrhoea' cases Behind the Headlines critiques a story that appears in the media. Further information: http://www.nhs.uk/news/2016/04April/Pages/Warning-issued-over-alarming-rise-in-super-gonorrhoea-cases.aspx