Kkristalinebis evolucia da kataraqta

Bbrolis anatomia

brolis embriogenezi

cilis sinTezis lokalizacia

xerxemlianTa kristalinebis gel eleqtroforezi da

imunoforezi

evoluciurad stabiluri -kristalinebi

“rekapitulaciis” wesis uaryofa

xerxemlianebis evoluciuri xis koreqcia kristalinebis evoluciis

safuZvelze

evoluciurad mdgradi -kristalinebis gamovlena Canasaxovan brolSi

evoluciurad mdgradi –kristalinebis maskireba Tvalis

brolSi

evoluciurad mdgradi -kristalinebis gamovlena kataraqtian brolSi

-kristalinebis maskirebis fenomenis axsna

ganviTarebad brolSi dnm-s da rnm-s sinTezis lokalizacia

cilebis SeRebva S-S jgufebze

maionizebeli gamosxivebiT dazianebuli Canasaxis broli

normaluri Canasaxis broli

r e z i u m er e z i u m e• 1. xerxemlian cxovelebSi aRmoCenilia

evoluciurad mdgradi -kristalinebi;• 2. molekulur doneze ar dasturdeba

“rekapitulaciis wesi”;• 3. imunohistoqimiuri meTodebiT aRmoCenilia

kristalinebis maskirebis fenomeni, romelic aixsneba kristalinebis sxvadasxva struqturuli mdgomareobiT;

• 4. dadgenilia, rom kataraqtian brolSi -kristalinebi destruqturirebulia;• 5. maskirebis da demaskirebis fenomenebi

saSualebas iZleva Tvalis broli gamoyenebuli iqnes modelad kataraqtogenuli faqtorebis Seswavlisas, rac kataraqtis mkurnalobis axali meTodebis Seqmnis perspeqtivebs gvisaxavs

• Harms MJ, Wilmarth PA, Kapfer DM, Steel EA, David LL, Bachinger HP, Lampi KJ Laser light-scattering evidence for an altered association of beta B1-crystallin deamidated in the connecting peptide. Protein Sci 2004 Mar;13(3):678-86.