Kirk Man Beginners Guide Web[1]

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IMPORTANT

The material in this guide is for informational use only. It should

not be used as a substitute for advice from a health care professional.

Please consult with a health care professional regarding the application

of this material to your own personal needs and situation.

This publication is not intended to diagnose, treat, cure or prevent

any disease.



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INTRODUCTION 6What if I Don’t Have A Doctor Right Now? 6So Where Do I Begin? 7What Is a Poor Nutritional Profile? 7Products to Correct a Poor Nutritional Profile 8

How Long Should I Try These Products? 10 SPECIAL DIETS 11

The Gluten-Free/Casein-Free Diet Explained 11How Long Must I Use the GF/CF Diet? 11

Casein Restriction 12Gluten Restriction 13

Frequently Asked Questions about the GF/CF Diet 14The Specific Carbohydrate Diet (SCD) 15

THE IMPORTANCE OF GASTROINTESTINAL HEALTH 16Signs of Gastrointestinal Disturbances 16The Intestinal Immune System 17Gastrointestinal Tract: A Top Priority 18Digestive Function 18

Digestive Enzymes 19Digestive Irregularities 19

How Long Should the Trial Period be on Enzymes? 21Probiotics 21How Long Should the Trial Period be on Probiotics? 21

IMMUNE SUPPORT 22General Facts About Our Immune System 22Signs of Immune Deficiencies 23Sleep Issues 24

BIOCHEMICAL PATHWAYS 25Sulfation 25Methylation 25Oxidative Stress 26

BEHAVIORAL CONSIDERATIONS 27

TOXIC LOAD/HEAVY METALS 29

What Could be Signals of a Toxic Load Burden? 29Minimizing the Toxic Load 30Detox-Aid Advanced Formula 30How Does Detox-Aid Advanced Formula Work? 30Heavy Metal Detoxification 31

DON’T OVERLOOK THE HYPOALLERGENIC FACTOR 32Why Aren’t All Products Made to be Hypoallergenic 33What Have Been the Results of Individuals Using

Kirkman’s Hypoallergenic Line? 33 IDEAS ON HOW TO GET YOUR CHILDREN TO

TAKE NUTRITIONAL SUPPLEMENTS 35 APPENDIX A 36

Step-by-Step Recap of Interventions 36

The Top Three Interventions to Try 36Next Possible Steps 36The More Complicated Interventions 36

Laboratory Testing 37Kirkman’s Customer Service Staff and Technical

Staff Can Help 37NOTES 38

Kirkman Contact Information 39

TAble OfcONTeNTs

TAble Of cONTeNTs



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beGINNeR’s GUIDeTO bIOMeDIcAl

AND DIeTARy

INTeRVeNTIONs



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What If I Don’t Have a Doctor Right Now ?Kirkman always recommends that the interventions

described in this guide be carried out under the care

of a physician who specializes in the care of individuals

with sensitivities. Such doctors can be hard to locate

and once located can have a significant waiting period

for appointments. Add to this delay the time needed

to perform necessary laboratory tests, and it can be

an extremely long time before the physician begins a

treatment regimen for your child. In the meantime, you

may want to try certain supplements or special diets.These interventions are okay to try on your own as long

as you follow the instructions regarding the diet and on

supplement labels.

INTRODUCTION

Biomedical and dietary interventions in individuals can be very

challenging and complex. This guide is an attempt to simplify

the approach and provide an understanding and background for

biomedical interventions, along with a logical sequence for theindividual or parent and doctor to follow.

Many Kirkman customers attend conferences, read articles or

books, hear media programming or consult with their physician

only to come away overwhelmed, confused and unsure where

to begin. This guide should help map out a logical approach for

the parent and doctor to agree upon. It is formatted so as to

coincide with the information found on the “Kirkman Roadmap”

that is on the inside cover of this book or you can download or

order from Kirkman’s website at www.kirkmanlabs.com.

A simplified recap of the step-by-step interventions described

in detail in this guide is provided in Appendix A . This recap is

provided to help you prioritize the biomedical and dietary con-

siderations that may meet your special requirements.

You may want to try nutritionalsupplements to get started.



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So Where Do I Begin?

Generally speaking, most physicians recommend correcting poor nutri-

tion first, since most individuals with special dietary requirements exhibit

poor eating habits. Often this involves basic nutritional supplements as

well as a special diet, although one can be done without the other to

start. If you are already on a special diet, just start the supplementation,

while if you are not on either, you may start one or the other or both.

What Is a Poor Nutritional Profile?

A poor nutritional profile is a series of nutritional deficiencies that may

be present in an individual. It is very prevalent in individuals with dietary

sensitivities for numerous reasons.

Some of these reasons include:

• Specialdietssuchasthegluten-free/

casein-free(GF/CF) ortheSpecificCarbohydrateDiet

(SCD)maybeinplace,

which are not nutritionally balanced.

• Aperson’stastesandattitudescan

be such that an individual’s diet is

very deficient in vitamins, minerals,

or other nutritional necessities.

• Afacetofbiochemistrycanbe

irregular, making the

absorption of nutrients sub-optimal.

Poornutritioncanoftenbe(thoughnotalways)

recognized by:

• Visionissues

• Unhealthyskintone

• Extremetirednessorlackofenergy

• Behavioralissues

• Failuretothrive

• Frequentillness

Parents often detect some or most of these conditions prior to a physi-cian’s evaluation or laboratory testing.

Correctingapoornutritionalprofileiscrucialtogoodhealthinindi-

viduals with dietary sensitivities. For those on a casein free diet, calcium

Many children with sensitivities crave thefoods to which they are allergic.



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supplementation is essential to proper bone development and growth.

Furthermore, a comprehensive vitamin and mineral supplement is es-

sential when the diet is unbalanced and deficient, which is often the case

if all food categories including protein, fruits, vegetables and carbohy-

dratesarenotconsumed.Codliveroilandomega-3fattyacidsupple-

ments can help support good vision and healthy skin. Irregularities in bio-

chemicalpathwaysareoftensupportedbyB-6/magnesiumsupplements,

folic or folinic acid, or sulfation aids.

Certainnutrientsareessentialforpropersupportoftheimmunesys-

tem.Zinc,vitaminA,vitaminC,vitaminE,andseleniumareexamples

of nutrients that improve immune response. Sub-optimal levels of these

nutrients can sometimes lead to poor immune response.

A physician’s evaluation and laboratory testing will help confirm these

deficiencies and point you and the doctor in the right direction, but until

such time as that evaluation and testing takes place, these nutritional

options are safe and do not cause serious side effects as long as one does

not exceed safe levels that your nutritionist or physician recommends.

Sometimes a poor nutritional profile can be due to enzyme insufficien-

cy. If this is the case, even eating a well balanced diet and taking supple-

ments may not be the entire answer. Pancreatic digestive enzymes each

do a specific job and digest a specific food group. Individuals deficient in

lipase probably won’t digest fats and oils properly and won’t fully absorb

oilsolublenutrientslikevitaminsA,DorE.Thosedeficientinlactase

won’t digest lactose and may be lactose intolerant. Other people may

have a shortage of starch digesting enzymes or protein digesting en-

zymes. When this is the case, usually digestive discomforts such as bloat-

ing or indigestion are present to help the parent or physician recognize

the problem. When these situations are present, then supplementing

with the proper digestive enzyme product may improve poor nutrition.

Products to Correct a Poor Nutritional Profile

The selection of products used to correct a poor nutritional profile

should be based on the individual’s needs and how aggressive an ap-

proach the individual or parent wishes to take.

If the patient is extremely sensitive or seems to have severe gastroin-testinal issues, the less aggressive approaches would be recommended.

Regardlessofwhichapproachisutilized,beginwithabouta1/4dosefor

a few days and gradually work up to the recommended dose. This will

minimize any potential side effects or sensitivities.



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The most aggressive approach to correct a poor nutritional profile

wouldbeaformofSuperNu-Thera®,thehighB-6/magnesiummulti-

vitamin/mineraldevelopedbyDr.BernardRimland.Manyclinicalstudies

with positive outcomes have been done on this type of product using a

variety of subjects. Super Nu-Thera® comes in liquid, powder, capsule

and tablet forms, some flavored and others hypoallergenic in nature.

The hypoallergenic forms are generally recommended due to the ex-

treme sensitivity of many patients to flavoring agents and sugars. Some

children, however, need the product flavored in order to get compliance

sothoseformsarealsooffered.AdosagechartbasedonDr.Rimland’s

initial recommendations is enclosed with Super Nu-Thera® orders and is

outlined below. The dosage is based on weight.

This dosage chart only refers to the three original forms of Super Nu-

Thera®: powder, liquid, and caplets. Some newer forms of the product

such as Nu-Thera® and hypoallergenic capsules do not correspond ex-

actly. In those cases, the product labels or Kirkman’s customer service or

technical departments can be of assistance on the correct dosage.

Asmentionedbefore,alwaysstartbygivinga1/4doseforafewdays

and gradually increase the dosage every few days until the desired dosage

isreached.SomedoctorsrecommendlessthanDr.Rimland’ssuggested

dosage.

Super Nu-Thera® and Nu-Thera®products are available in various tastes

and textures.



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A less aggressive approach may be tried utilizing Nu-

Thera®, which is a condensed form of Super Nu-Thera®. It

consists of the same basic nutrients at lower potencies in an

easytoswallow,small,#3capsule.Thisproductishypoaller-

genic and has less taste impact if the capsule is opened and

the powder is mixed in food or drink. Another product suit-

able for a middle-of-the-road approach is Thera Response, a

hypoallergenic,mid-potency,multi-vitamin/mineralproduct

formulated at the request of several physicians desiring a

mid-potency product.

The least aggressive plan would be to use a standard

multi-vitamin/mineralproductsuchasourChildren’sChew-

ableMulti-Vitamin/MineralWafersorChildren’sMulti-Vita-

min/MineralHypoallergeniccapsulesandaddthevitamin

B-6andmagnesiumgraduallyusingKirkman’sVitaminB-6/

MagnesiumChewableWafersorP5P/MagnesiumGlycinate

capsules.EachB-6chewablewafercontains50mg.ofB-6with25mg.of

magnesium. Start with one daily and work up to as many as five daily ,

provided the increased dosages seem to be improving the child.

Byusingmulti-vitamins/mineralswithhighB-6/magnesiumcontent,you

are also trying an intervention that addresses behaviorial, learning and

social issues, as well.

Regardless of which approach you use, if the individual is on a casein-

freediet,besuretoaddacalciumsupplementsupplyingatleast800mg.

daily. Kirkman has calcium supplements available in powder and capsule

forms.

How Long Should I TryThese Products?

You should use the products for

at least four weeks in order to pro-

vide an opportunity for an improve-

ment to be seen. If no results are

seen,thehighB-6/magnesiumpor-

tion can be dropped, and you can

revert to a more standard potencymulti-vitamin/mineralproduct.

AddB-6orP-5-P/Magnesiumto a good multi-vitamin.

Nu-Thera® and Thera Response offer mid-potencies.



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The Gluten-Free/Casein-Free Diet Explained

Many individuals find it necessary to go on a

gluten-and/orcasein-freedietasaresultoffoodallergies or medical conditions. Whatever the rea-

son,managingagluten-free/casein-free(GF/CF)

diet is not as easy as it sounds. One must learn

which products contain casein and gluten and

get used to carefully reading product labels. In

addition, one must learn where casein and gluten

can “hide” from the consumer’s view on a la-

bel. Once the parameters are understood, what

seemed like an impossible diet to comply with

becomes much more tolerable and manageable.

How Long Must I Use theGF/CF Diet?

The trial period should be about six months. If

significant improvement results, the diet could

prove to be a lifelong necessity. If no improve-

ments are noted, then obviously the diet need

not be continued. Be sure to use caution in your

evaluation, because sometimes improvements are

slow and subtle, and going off the diet can cause

some regressions.

Vegetablesareasourceofgoodnutrition on special diets.

SPECIAL DIETS

The individual may already be on a special diet before trying

to correct poor nutrition. If so, certainly stay on track if it has

improved the individual’s health, which it does in many cases. If

a special diet is not being used, this is a “must” to try. The mostpopular diet with the greatest success rate is undoubtedly the

gluten-free/casein-free(GF/CF)diet.AllofKirkman’sproductsare

casein- and gluten-free for this reason.



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Casein Restriction

Caseinispresentindairyproducts.Eliminatingcaseinsoundssimple—

just remove all dairy products from the diet including:

• Milkinallforms(includingskim,powderedand

goat’smilk)

• Butter

• Cheese

• Yogurt

• Lactose

• Whey

• Caseinates

Unfortunately,itisnotthatsimple.Mostpreparedfoodscontaindairy

products such as powdered milk, cheese or whey. Soup mixes usually

do, as well. You must read the labels carefully to be sure dairy products

are not present in frozen or canned foods. You must also check bakery

goods and snacks for the presence of the

above casein sources. Reading the labels is a

critical issue.

There are acceptable casein-free sub-

stitutes available. Milk alternatives made

with rice, potato or soy are commercially

available in specialty sections of grocery or

health food stores. Some sensitive individu-

als also react to soy, so be careful on this

issue. There are also dairy-free yogurts and“mock”cheeseproductsmarketed.Using

your imagination along with these specialty

products will allow you to create your own

versions of recipes that traditionally contain

dairyproducts.A1998bookbyLisaLewis,

Ph.D.entitledSpecial Diets For Special Kids

gives hundreds of valuable creative ideas for

casein- and gluten-free diets.

Eggsandmosttypesofmayonnaisedonotcontaincasein.Thereare

also dairy-free margarines available, but read the labels carefully becausesome contain whey.

Special diets require that youread all food labels carefully.



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Gluten Restriction

Gluten restriction is more difficult and requires more effort than casein

restriction. It is also easier to be “fooled” because gluten can be hidden

in a lot more products. The following grains contain gluten and must be

avoided:

• Wheat

• Oats

• Barley

• Rye

• Semolina

• Spelt

• Triticale

• Kamut

These grains are present in most commercial cereals, breads, flours,

baked goods, instant mixes and prepared foods. Reading the label care-

fullyismandatorytoensuretheirabsence.However,thisoftenbecomes

challenging because natural or artificial flavorings along with spices,

gravies and dressings can also contain gluten. If in doubt, you will have to

check with the manufacturer of the product.

Fortunately, there are safe, alternative grains and flours for gluten-free

diets. Acceptable grain substitutes are:

• Sweetrice

• Brownrice

• Whiterice

• Tapioca• Potatostarch

• Beansflours(GarfavaandGarbonzos)

• Lentil

• Corn

Another factor that makes gluten-free dieting difficult

is the “contamination factor.” For example, wheat flour

makes a very good anti-caking or anti-stick compound for

some manufactured or packaged products and is not listed

on the label because it is not a component of the actual

product. Rather it is used to “dust” the manufacturing orpackaging equipment to prevent tackiness. Also, a fac-

tory that packages a gluten-free product may use the same

packaging line as it did for one containing gluten without a

thorough cleaning in between. Know your supplier and, if

Kirkman’s non-porous, washable

production rooms can be completelywashed down after each operationassuring a completely casein and glutenfree manufacturing facility.



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in doubt, call and ask about potential contaminations and request a copy

of the supplier’s standard operating procedures, which should outline

how their equipment is cleaned. If the supplier or manufacturer will not

share this information with you, chances are they are hiding something.

If everyone in the family is not gluten-free, be careful of in-home

contamination from pots, pans, cutting boards, utensils, countertops and

dishes. Most individuals sensitive to gluten are sensitive at minute levels

(afewpartspermillion).Whatmightseeminsignificantsuchaswheat

residue on a breadboard could have serious repercussions to the gluten-

sensitive person.

Aswithcasein,LisaLewis,Ph.D.,hasextremelyvaluableandcreative

ideas for gluten-free cooking in Special Diets For Special Kids. This publi-

cationisremarkablyhelpfulinunderstandingandimplementingaGF/CF

diet.ManyparentsbeginningtheCF/GFdietworryaboutfindingenough

foods which are “legal” for the diet but still nutritious and fulfilling for an

individual. These alternatives are described in this book.

Frequently Asked Questions about the

GF/CF Diet

Q:Doesn’teveryoneneedtodrinkmilktogetcalcium?

A:No.Calciumisavailablefromnon-dairysourcessuchaspotato,rice

or soy milks, plus calcium supplements can be used to ensure the daily

recommended amount is consumed.

Q:Don’tallchildrenneedmilktobehealthy?A:TheAmericanDairyAssociationhasledparentstobelievethat.The

truth is, children do very well without milk, as long as calcium require-

ments are obtained elsewhere.

Q:Whatelsebesidesmilkhascasein?

A:Allformsofmilk(powdered,goat’s,skim)pluscheese,butter,cream

cheese, cottage cheese, whey and caseinates contain casein.

Q:Whatcontainsgluten?

A: Wheat, oats, barley, rye, semolina, some food starches, alcohol from

grain, spelt, and kamut contain gluten. A lot of prepared packagedfoods contain gluten as do many restaurant foods. Flour, crackers, and

snack foods also generally contain gluten.



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Q:MychildonlylikesMcDonald’sChickenMcNuggetsasaprotein

source.Dotheyhavegluten?

A: Yes, they are rolled in wheat flour before frying. You can make your

own nuggets, however, using rice flour or bean flour. These are gluten-

free.

Q:DoFrenchfrieshavegluten?

A: Only if wheat flour is used as an anti-stick agent. Ask the restau-

rant. Also be careful about the possible contamination with gluten if

the fries are cooked in pre-used frying oil.

Q:Dovitaminsandothersupplementshavecaseinorgluten?

A:Theycan.Checkthelabel’slistofingredients(required)andcheck

for milk products like caseinates, lactose or whey, and for any grains or

starches that could contain gluten. Also, some flavorings can contain

gluten. Kirkman products are all casein- and gluten- free.

Q:I’veremovedcaseinandglutenfrommychild’sdietandhe/shestill

seemstobeallergictofoods.Whatdoesthismean?

A: First, check to make sure no hidden casein or gluten could be pres-

ent. Some individuals are also allergic to other ingredients such as soy

and corn. Ask your doctor to check this out.

The Specific Carbohydrate Diet (SCD)

This diet has been tried on individuals who have severe gastrointestinal

discomforts such as bloating, gas, diarrhea, constipation and severe food

intolerances.

TheSCDdietlimitstheintakeofsugarstosimplemonosaccharidessuch

as honey, fructose and dextrose, and eliminates the intake of disaccharides

and polysaccharides such as sucrose, molasses, mannitol, sorbitol, xylitol and

inulin. It also greatly restricts the consumption of starches and other types

of carbohydrates. The theory behind the diet is based on the assumption

that toxic organisms present in the gut thrive on disaccharides and starches,

and that their elimination will starve out these organisms. The main foods

consumed on this diet are, therefore, protein, vegetables, fruits, seeds and

nuts.AbookonthisdietbythelateElaineGottschallisentitledBreaking

the Vicious Cycle: Intestinal Health Through Diet.



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Signs of Gastrointestinal Disturbances

There are many distinct, recognizable signs of gastrointestinal distur-bances, but if the individual is unable to communicate the signs may not

be obvious to the caregiver. Some of the signs are:

Abdominal discomfort or cramping (often includes crying, scream-•ingorholdingtheabdomen)

Constipation,diarrhea,oralternationbetweenthetwo•Indigestion, bloating, gas•Inadequate digestion evidenced in stools•No formed stools•Inflammation•Yeast or bacterial overgrowth•Serious food sensitivities•

When gastrointestinal disorders are suspected, a thorough examination

by a gastroenterologist is called for. The evaluation very well may include

THE IMPORTANCE OFGASTROINTESTINAL HEALTH

Cleaningupthegastrointestinaltractisimperativeinsensitive

individuals. One of the special diets above may be a very goodstart in many patients, but may not complete the job.

Physicians have known for centuries that a well-functioning gas-

trointestinal tract and digestive system are crucial to good health.

When digestion is working optimally, other organs and systems in

the body have a better chance of working optimally, as well. This

is because the digestive system is responsible for processing the

nutrients in our food, which in turn are used for growth, repro-

duction, development, tissue repair, healing, and for the normal

functioning of every organ in the body. Therefore, the digestive

system is very much responsible for supporting the health of thebody as a whole.

In addition to providing fuel for the body through nutrition, the

intestinal tract also plays an integral role in the functioning of the

immune and nervous systems. This association is often referred to

as the “gut-brain connection.”



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an endoscopy and biopsy. Based on this evaluation, the physician has

many options to help. These options may include:

Prescription anti-fungals, antibiotics, or other drugs•OTCmedicationsorsupplements•SpecialdietsincludingGF/CForSCD•Probiotics to support good flora and crowd out undesirable or-•ganisms

Products that support tissue healing•Digestiveenzymes•

The Intestinal Immune System

The intestinal tract represents an important bar-

rier between the external world and the internal

environment, and there are a number of immune

mechanisms built into the gut lining that help en-sure that invading organisms from the outside are

neutralized before they can do potential damage

insidethebody.Itispostulatedthatupto70%of

the body’s immune system is associated with the

digestive tract. This intestinal immune system is

knownasGut-AssociatedLymphaticTissue.

When the specialized immune cells that line

the digestive tract detect an unknown or possibly

harmfulsubstance(calledanantigen),theysignal

the immune system to provide antibodies to helpfight these antigens. Another immune defender

that is present in the lining of the gut wall is

knownasSecretoryImmunoglobulinA(SIgA).

When antigens are present, SIgA can help to trap

them in the mucous layer of the intestinal tract,

thereby rendering them ineffective. The immune

system has an integral involvement with the di-

gestive system, and imbalances of the gastrointes-

tinal tract often occur concurrently with immune

dysfunction. Further discussions of the immune

system will follow later in this guide.

Optimal digestion positivelyimpacts other body systems.



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Gastrointestinal Tract: A Top Priority

Because of its involvement in the rest of the body processes, the gastro-

intestinal tract should be the top priority in getting proper care for sensi-

tive individuals. Without the proper functioning of the GI tract, trying to

correctotherareasmaybefutile.Discussthisprioritywithyourphysician

earlyinyourassociation.Priortoanexaminationbyaphysicianand/oragastroenterologist, one can very safely try a special diet, a comprehensive

probiotic or a digestive enzyme to help alleviate gastrointestinal discom-

forts. Often these interventions improve the quality of life for the indi-

vidual by improving overall health, gastrointestinal status and discomfort

related behavioral issues.

Digestive Function

Closelyrelatedandsometimesconcurrentwithgastrointestinaldis-

comforts are digestive irregularities. These are often present when thegastrointestinal tract is not healthy.

The primary function of the digestive tract is to break down the large

particles of food that we eat into small molecules that can cross over the

intestinal lining, enter the bloodstream, and become fuel for the various

metabolic processes in the body. In

order to accomplish this function,

the intestinal tract is involved in four

primary activities: digestion, absorp-

tion, assimilation and elimination.

Digestionisthebreakdownofthefood particles into usable nutrient

forms. Absorption is where those us-

able nutrients cross the gut wall and

pass from the intestine to the blood-

stream. Assimilation is utilization of

the products of digestion for energy

and the body’s metabolic processes,

while elimination is, of course, the ex-

cretion of the body’s waste products

through the intestines and kidneys.

Digestionbeginsinthemouthwithsalivarysecretions,thencontinues

in the stomach where secretions of hydrochloric acid and pepsin form a

material called chyme. The pancreas then releases enzymes into the duo-

denum of the small intestine as the chyme also passes into the duodenum

Digestionbeginsinthemouthwithsalivarysecretions.



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Digestionandabsorptionthencontinuesandisessentiallycompletedin

the small intestine. The final stage of digestion is completed in the large

intestine and colon where waste accumulates and is then eliminated.

Digestive Enzymes

Digestivefunctionirregularitiesareprevalentinsensitiveindividuals.

The majority of these are the result of the stomach not secreting enough

hydrochloric acid or the pancreas not releasing enough pancreatic diges-

tive enzymes. When these situations occur (and they often occur togeth-

er),supplementaldigestiveenzymesareoftentriedtohelpsupportthe

insufficiencies.

When we talk about supplementing with digestive enzymes, it is the

pancreatic enzymes that we are talking about. These are the enzymes

that have specific jobs and act only on specific types of food substrates.

When digestive enzyme supplementation is called for or recommended

by a health professional, it is imperative that the proper combination ofenzymes is chosen so as to address the problems at hand. For example,

lipase only digests fats; it does not act on proteins or sugars. Sucrase only

digests sugars; it has no effect on fats or proteins. Proteases and pepti-

dases act on protein, casein and gluten -- other enzymes do not.

Digestive Irregularities

There are many recognizable indicators that digestive discomforts are

present in an individual. Some of these can be:

Bloatingand/orabdominalpainorcramping• Irregular bowel habits or abnormally loose or mushy stools•Constipation,diarrhea,oralternatingbetweenthetwo•Discomfortaftereating•Excessivegas•Extremesensitivitytodairyandgrains•Veryodorousbowelmovements•Undigestedfoodinthestool•Oily,greasy,and/orfloatingstools•

As discussed earlier, a specific enzyme combination must be selected

based on an individual’s specific needs. There are many different enzymeproducts in the marketplace including :

Lipase-addressesfatdigestion•Lactase-aidslactoseintolerance•



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Peptidase/Protease-digestproteinsandpeptidesincludingcasein•and gluten

DPPIV(Peptidase)-targetscaseinandgluten•Multi spectrum enzymes - digest all food groups•Carbohydratedigestingenzymes-addresscarbohydrates•

If you know that a person needs a specific enzyme, such as lipase for

fats,youcanlookforthatspecificenzyme-containingproduct.Ususally,

however, individuals are not sure, in which case a multi-spectrum diges-

tive enzyme would be the product of choice. Multi- spectrum enzyme

products help digest all food groups including proteins, fats, starches and

other carbohydrates, sugars, celluloses and fiber.

Kirkman has advanced digestive enzyme products containing Isogest®,

a patent pending enzyme component with isomaltase activity. No other

commercially available enzymes contain the Isogest® fraction. Kirkman

Enzym-CompleteII/Isogest®formulaandMaximumSpectrumEnzym-

CompleteIIDPPIV/Isogest®Formulaarethetwoproductsofchoice.The

latter product is fruit-free, which is important in those individuals sensi-

tive to pineapple or papaya fruit.

No other commercially available enzymescontain the Isogest® fraction.



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How Long Should the Trial Period be on Enzymes?

Improvements of the digestive symptoms should be quite rapid. If no

improvements are noted in about four weeks, supplementation can be

stopped.

Probiotics

Often, enzyme insufficiency is accompanied by a poor ratio of gut flora

present in the intestinal tract. A healthy intestinal tract normally has a

good balance between healthy, desirable flora and unhealthy bacteria

or yeast, while a compromised intestinal tract lacks this good balance of

flora. In these instances taking a probiotic with the enzymes is a pos-

sible solution and helps maximize the enzyme activity. The probiotics are

blends of beneficial flora that set up residence in the small intestine and

help to crowd out the unwanted organisms. When enzymes and probiot-

ics are taken together, it is recommended that the enzyme be taken at the

very beginning of the meal with the probiotic following about one halfhour later. When enzymes are not being used concurrently, the probiotic

should be taken at the beginning of the meal.

How Long Should the Trial Period be on Probiotics?

The trial period on probiotics should be about two

months because it takes time for the organisms to set up

residence and begin crowding out the unwanted organ-

isms. As a result, the improvements can be quite gradual

and subtle. Improved stools and fewer digestive symptoms

should be evident after the trial period.

Probiotics are beneficial bacteria that helpcrowd out unwanted bacteria.



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IMMUNE SUPPORT

General Facts About Our Immune System

The immune system is a complex and dynamic network of many

soluble components including cells, membranes, and a mini circulatory

system separate from blood vessels. These entities all work together to

protect us from infection by opportunistic microbes, bacteria, viruses,

fungi and parasites that abound in our environment. The immune

system also constantly scans our bodies for any signs of abnormal cell

growth.

Our body’s first line of defense

against unwanted intruders consists

of our skin, our body enzymes, such

as saliva and stomach acid, and our

protective epithelial cells, which line

our body’s mucosal surfaces. These

physical factors combined with spe-

cialized white blood cells make up

our innate immune system, which is

rather non-specific and broad- spec-

trum in nature.

More complicated is our body’s

adaptive immune system, which is

far more sophisticated and deals

with specific fragments of any potentially harmful or foreign material.

These fragments are called antigens and they are dealt with in the im-mune system by antigen receptors. Once an antigen receptor adapts to

one of these invading fragments, it retains antigenic memory so that it

may quickly neutralize that antigen if it invades the body again.

There are many specialized white blood cells that work together

to coordinate overall immune response. “T” cells are responsible for

cellular immunity while “B” cells produce antibodies in response to

antigens. Then there are NK – natural killer cells that kill off certain

infected targets, granulocytes, which remove bacteria and parasites by

releasing toxic compounds, and macrophages that engulf and destroy

foreign material.

TherearetwomajortypesofTcells:Th1andTh2.Th1cellsdrive

immunogenicresponses,whileTh2cellsdriveantibodyproductionbyB

cellsandareespeciallyimportantinrespondingtoallergens.Compro-

Pictured are viruses attacking healthy cellsin the blood.



23

misedimmunesystemsusuallydisplayaTh1toTh2cellshiftthat

causes an increase in food and environmental allergies .

The success of our immune system relies on an incredibly elabo-

rateanddynamicregulatory/communicationsnetworkcomposed

of millions of cells and is a sensitive system of checks and balanc-

es. Genetic make-up and environmental invasions can result in

the immune process going terribly wrong. Serious infections and

other health consequences can result.

Frequent illness may be a sign of aweak immune system.

Signs of Immune Deficiencies

The signs of an immune problem are often quite easy to recognize

over time. Persistence of the following conditions are key to suspecting

immune deficiencies:

Frequent illness•Continuousfoodallergiesoranincreasednumberof•such allergies

Inadequate detoxification as indicated by laboratory testing•Lowglutathionelevelsasindicatedbylaboratorytesting•Impaired methylation•

Sensitive individuals are especially prone to immune problems. In the

case of children, parents’ observations conveyed to the physician are ex-

tremely important in helping the doctor recognize the problem, which is

often hard to judge at an office visit.

There is a long list of nutritional products that support a healthy im-

mune system including :

Zinc•VitaminA•VitaminC•VitaminE•Selenium•Beta Glucan•CoenzymeQ-10orIdebenone•N-AcetylCysteine•Colostrum•CranberryExtract•Garlic• Kirkman carries a wide variety of

products that support the immunesystem.



24

OliveLeaf•Goldenseal•ReducedL-Glutathione•DimethylglycineorTrimethylglycine•

You may recognize some of the above nutrients as being present in the

multi-vitamin/mineralyoumaybeusing.Tobettersupportacompro-

mised immune system, additional supplementation of the nutrient is rec-

ommended.Increasingzincto50mg.daily,vitaminCto1000-3000mg.

daily,vitaminEto200-400IUdaily,seleniumuptoatleast75mcg.daily,

andCoenzymeQ-10upto100mg.dailymaybebeneficial.

Kirkman also carries other combination products comprised of many of

the above immune boosting nutrients.

Sleep Issues

Sleep issues in sensitive individuals are not much different from sleep

problems in the general population. These can include:

Trouble falling asleep•Periodic night awakenings•Restlessness•Nightmares•

It must be remembered, however, that these sleep tendencies could be

all or in part due to underlying conditions such as digestive issues, gastro-

intestinal tract issues such as ulceration, reflux, or inflammation or othercauses of pain.

The dietary supplements often useful in supporting restful sleep are:

Magnesium•Melatonin•L-Taurine•GABA•

All of these supplements are safe and usually without side effects, and

should be tried one at a time for about a week in the order listed above.

If one supplement does not seem to help, stop and try the next one .

Kirkman’s sleep support products in-cludeMagnesium,Melatonin,L-Taurine,and Gaba



25

Sulfation

The sulfation process is linked to an enzyme system known as phenol

sulfotransferase(PST).Normally,PSTisinvolvedinaprocesscalledsulfo-

conjugation, whereby a group of potentially harmful chemicals known as

phenols are attached to sulfate and thereby eliminated from the body.

When there is a deficiency of sulfate in the bloodstream, phenolic com-

pounds may build up in the body, and this in turn can interfere with neu-

rotransmitter function. Sulfate deficiency and the resulting impairment ofPST activity may explain some sensitivity reactions to a variety of phenol-

containing foods, such as apples, grapes, chocolate, food colorings, and

some herbs and spices.

Verysensitiveindividualsseemtohaveonlyabout1/5thofthenormal

level of sulfate in their bodies, the rest having been excreted excessively in

the urine. In addition to the phenolic buildup described previously due to

sulfate deficiency, sulfur and sulfate also play other important roles in the

body including:

• Detoxificationprocesses• Releasingcertainpancreaticdigestiveenzymes

• ActivatingthehormoneCCK

Sulfationcanoftenbesupportedbyoralsulfate,topicalEpsomsalt

products,orbygivingindividualsEpsomsaltbaths.Magnesiumsulfate

productsandEpsomsaltbathsareperfectlysafeinterventionsthatcanbe

tried at home without concern by simply following the label instructions.

Methylation

Methylation is a series of very important biochemical reactions in the

body that are responsible for overall good health. In sensitive individuals,

this process is very often lacking to some degree, making these individu-

BIOCHEMICAL PATHWAYS

Sensitive individuals often exhibit certain tendencies in sever-

albiochemicalpathways.Eachoftheseindividualpathwayshas

a unique purpose and an abnormality can lead to health issues.

A description of those pathways most often disrupted follows.

Many individuals with sensitivities havereduced sulfate levels in their body.



26

als poor methylators. A properly functioning methylation pathway has

rewarding health benefits including:

Proper brain function•Healthydetoxification•Proper reproduction•DNAprotection•Healthy,normal,non-prematureagingprocess•

There are many nutritional supplements that support proper methyla-

tion. You should discuss these options with your physician carefully, be-

cause each individual is unique and requires a methylation improvement

program specifically tailored to his or her requirements. Products your

doctor may use to support the methylation process include:

MethylVitaminB-12•DimethylglycineorTrimethylglycine•Folic or Folinic Acid•VitaminB-6•SAMe•Selenium•Zinc•Phenol reducers•

The methylation pathway is complicated and a physician should

be consulted to determine interventions.

Oxidative Stress

Individuals with dietary sensitivities can have elevated oxidative

stress.Certaintoxinscalledoxidantsenterthebodyandbegin

causing oxidative tissue damage known as oxidative stress. These

toxins can be in the form of chemicals, pesticides, heavy metals,

and other environmental pollutants. Some of these cell-injuring

oxidants are known as “free radicals.” It is important to minimize

oxidative stress damage by consuming antioxidants, which retard

theprocess.SomeoftheseantioxidantsincludevitaminsC,E,and

A, selenium, melatonin, carnosine, carnitine, pycnogenol, grape-

seedextractandCoEnzymeQ-10.Therearelaboratorymarkers

that measure levels of antioxidant compounds present in the body.Talk to your doctor about appropriate testing and subsequent

supplementation with antioxidants.

Kirkman offers a wide range of antioxidantsto support those with oxidative stress.



27

The most common behavioral disturbances involve the following symp-

toms:

Speech delay or absence of speech• Unabletoputwordsorsentencestogether•Learningdisabilities•Lackofsocialskills•Lackofeyecontact•Aggressive behavior•Passive behavior•Depression•Anxiety•Tics or abnormal neurological responses•

The list of supplements and interventions that have been used in deal-ing with these behavioral issues is long. Some of the more popular ones

include:

HighB-6/magnesiumsupplements•Highpotencymultiplevitaminsandminerals(somemayinclude•higherB-6/magnesiumpotenciesaswell)

DimethylglycineorTrimethylglycine•Taurine•Carnosine•Creatine•

Inositol•Omega-3fattyacids•Codliveroil•HBOT(HyperbaricOxygenTherapy)•CoenzymeQ-10orIdebenone•

BEHAVIORAL CONSIDERATIONS

Behavioral disturbances are very common in diet sensitive

individuals. Because each individual is different and displays dif-

ferent behavioral traits, it is challenging to find the right inter-

ventions for a given person. Often, laboratory test results areof no value here because what causes one individual to behave

a certain way may have quite a different effect on another.

Sometimes doctors and parents are forced to use trial and error

evaluations of various interventions until the correct regimen is

found for a given patient.



28

Youmayhavealreadytriedthemulti-vitamin/mineralsupplementation

withhighB-6/magnesiumasyourfirstinterventionsoyouwillhaveevalu-

ated its effectiveness.

Often lack of eye contact due to insufficient vitamin A in the diet can

beimprovedbycodliveroil,asdemonstratedbyDr.MaryMegsonof

Richmond,Virginia.

Generally, a thorough examination by your physician is preferred before

any of the above interventions are begun, however many of the products

listed are perfectly safe and present no side effects when taken. So in

cases when a physician is not available for a period of time, vitamins, min-

erals,omega-3fattyacids,codliveroilandCoenzymeQ-10arecertainly

harmless to try and could prove very beneficial. It should be remembered,

however, that only one product should be tried at a time.

Otherinterventionslikedimethylglycineortrimethylglycine,HBOT,

creatine, carnosine and inositol normally require a physician’s involvement

for maximum safety.



29

TOXIC LOAD/HEAVY METALS

Substantial evidence is emerging linking many medical conditions

to negative environmental influences present in our world. Negative

environmental factors have been implicated in a myriad of medical

irregularities. The frequency of many of these medical conditions is

increasing, which leads to further speculation that outside environ-

mental causative factors are involved.

Included in the list of environmental insults that can affect disease

statesaretoxicchemicals,heavymetals,PCBs,andpesticidespresent

in the products we use, and contaminants in the air we breathe and

the water we utilize and drink.

These environmental pollutants can affect the body in numerous

ways. Natural body defense mechanisms such as immune response

can be bombarded with the insults, thereby becoming less effectivebecause of the toxic load.

Another area of intense research is how environmental factors af-

fect the genetic makeup of an individual. There are many genes in

our body that are considered “environmentally responsive,” which

means that they can be altered by environmental factors. If you

alter a gene’s makeup, the potential exists for changing the normal

development of a person. Some of these changes can be immediate

andsomemaytakemanyyearstomanifest.Dependingonwhich

gene is involved, an individual can become vulnerable to changes in

metabolic pathways, physical development, immune response, braindevelopment and function, and nervous system development and

function.

What Could be Signals of a Toxic Load Burden?

The following symptoms could be present as a result of toxic burden:

Learningorspeechdifficulties•Lackofsocialskills•Aggressive behavior•Passive behavior•Poor immune response•Biochemical pathway issues•



30

Kirkman Kleen™ personal care and cleaningproducts lines were designed without harshchemicals, allergens or toxins.

Minimizing the Toxic Load

Sensitive individuals often have severe toxic burdens. This can be com-

pounded by the fact that a biochemical pathway known as methylation is

often compromised. A doctor’s evaluation is needed to determine if this

pathway is not working properly. Nutritional interventions can support

improvement of this condition.

Certainnutrientsareconsiderednaturaldetoxifiersandcanhelpmini-

mize the negative impact of toxic exposures and enhance the body’s natu-

raldetoxificationprocess.Examplesofsuchvitaminsandmineralsarezinc,

vitaminC,vitaminEandselenium.Othernutritionalfactorsthatcanbe

helpful are taurine, N-acetyl cysteine and glutathione.

Being selective about the products we use or the foods we eat can great-

lyinfluenceourtoxicload.TheFDAhasalreadyissuedwarningsabouthow

muchfishweshouldeatbecauseofthemercurycontent.Usingotherfood

products or dietary supplements with ultra high purity - such as those witha hypoallergenic designation - is another means of minimizing our toxic

load. This is also true for personal care products and cleaning agents we

use. And don’t forget about the air we breathe and the water we drink

and cook with. The purer our water and air, the less environmental con-

tamination. Numerous air and water filtration products are available to

improve air and water purity. Kirkman has recently introduced the Kirk-

man Kleen™ line of personal care and cleaning products that are formulat-

ed with safe ingredients so as not to contribute to a toxic load in the home.

Detox-Aid Advanced Formula

When environmental toxins are encountered by the body, a detoxifica-

tion process must occur to prevent a toxic overload. In sensitive individuals,

the detoxification pathways are often compromised requiring the system to

obtaina“boost”fromtheoutside.Kirkman’sDetox-AidAdvancedFormula

was specially formulated to provide that “boost” to help support the body’s

natural detoxification processes.

How Does Detox-Aid Advanced Formula Work?

TheingredientsinDetox-AidAdvancedFormulaandhowtheyworktohelp the detoxification process are described below:

As toxins become active in the body, glucuronic acid combines with•the toxins to form a non-toxic molecule called a glucuronide which

can be excreted into bile, thereby eliminating the toxin. An en-



31

zyme called beta-glucuronidase present in the body largely as a by

product of intestinal flora can disassemble that non-toxic molecule

whichthenfreesuptheactivatedtoxinagain.CalciumD-glucarate

acts to prevent that disassembly process of the glucuronide by

becomingD-glucaro-1,4-lactone,thedirectinhibitorofthebeta-

glucuronidase. Without this inhibition process, the cleaving of the

glucuronide would lead to the toxin being reabsorbed by the intes-

tinal mucosa.

Turmeric is a powerful antioxidant that increases the formation of•the detoxifying glucuronides. Turmeric’s antioxidant properties

also aid glutathione in doing its job.

ReducedL-glutathioneisrequiredbythebody’scellsinorderto•detoxify.

N-acetyl cysteine provides cysteine that is used in the body to form•glutathione,thebody’scelldetoxifier.Cysteineisalsothemajor

source of taurine that is produced by the body.

Taurine is an essential component of bile formation. Bile flow into•the intestinal tract is a major detoxifiction route in the body, along

with sweat, urine, breath, hair and nails.

Milk Thistle contains silymarin which is a very powerful antioxidant•that supports the protection of cells. It also supports liver function,

which is instrumental in body detoxification processes. In human

and animal studies, silymarin has exhibited its protective effects.

OliveLeafExtractispresentinDetox-AidAdvancedFormulafor•controlling the growth of undesirable intestinal flora that tend to

thrive in the presence of sulfur compounds such as glutathione and

N-acetyl cysteine.

Selenium is present due to the fact that it is an antagonist toward•ingested metals including lead, mercury, aluminum and cadmium.

Heavy Metal Detoxification

Detox-AidAdvancedformulaassistsinthebody’snaturalremovalof

ingested heavy metals and works synergistically with heavy metal detoxi-

fyingcompoundssuchasDMSA,EDTA,Chemet,andDMPS.Thesechelat-

ing agents should be used only under the supervision of a physician, as

laboratory testing must be routinely performed to monitor kidney, liver

and cell conditions.

You may be in the beginning stages of trying to eliminate toxins thatare present in our environment. We should all be doing that. Some will

remain, however, as we still have to eat, breathe and drink to sustain our

lives.Kirkman’sDetox-AidAdvancedFormulacanhelptoenhanceour

bodies’ detoxification processes.

Detox-Aidsupportsthebody’snaturaldetoxification processes .



32

WehavealreadydiscussedtheGF/CFdiet,whichrestrictscaseinand

gluten in an individual’s diet. Other dietary restrictions may be necessaryfor sensitive individuals or individuals with special dietary requirements.

These may include soy, corn, rice, sugar, egg or preservatives.

As we work with parents and doctors in developing appropriate dosage

forms, it has become evident that many of our customers have extreme

sensitivities and allergies to many naturally occurring ingredients and

tonearlyallexcipients(inactiveingredients)

normally found in nutritional supplements and

traditional foods. It has always been Kirk-

man’s goal to formulate all products to be as

palatable as possible so as to make administra-tion and compliance easy, especially for the

parents. Some of the flavorings and formulation aids used to make these

products taste good are the very ingredients to which some of our cus-

tomers are sensitive.

Kirkman is committed to having a broad product line that will meet the

needs of all of our customers. To cover the needs of those children who

are extremely sensitive or allergic to many commonly used ingredients,

Kirkman has developed a full line of hypoallergenic products in two-piece,

hard-shell capsules. The capsule shell is made from plant cellulose, not

frombeeforporkgelatinasmostcapsulesare.Capsulesmanufactured

from beef or pork can contain potential allergens associated with animal

derived ingredients. Kirkman’s capsule shells, known as vegetable cap-

sules, are manufactured from plant cellulose derived from pine trees. This

fibrous cellulose is an inert material and is allergen free. Furthermore,

these hypoallergenic products contain no fillers, flavors, preservatives or

common formulating aids that could cause sensitivity or allergic reactions.

As a result, Kirkman’s hypoallergenic line is free of casein, gluten, soy, fla-

vors, colors, animal derivatives, sugar, heavy metals, pesticides and other

environmental impurities.

If you try some of the interventions discussed in this guide and seem to

notice a reaction or sensitivity to products that are flavored, colored or

contain potential allergens, it is strongly recommended that you try the

same product type in our hypoallergenic line. You may find that the reac-

tion or sensitivity disappears.

DON’T OVERLOOK THE

HYPOALLERGENIC FACTOR



33

Why Aren’t All Products Made to be Hypoallergenic?

Most manufacturers of nutritional supplements provide products to

drug chains, food chains and mass market distributors. The majority of

the population is not sensitive to a common list of ingredients usually

called “pharmaceutical excipients.” Some of the most common ingredi-

entsonthatlistincludestearicacid,gelatin,eggs,dextrose(cornsugar),

corn starch, sucrose, polyvinylpyrrolidone, sodium chloride, milk or dairy

derivatives, wheat or grain derivatives, and soy. In addition, various fla-

vorings and colorings are often used.

For those individuals without sensitivities or allergies to these ingredi-

ents or the impurities present in those ingredients, no problematic side

effects become evident to the user. Manufacturers use these standard

ingredients because of cost and because they contribute to production

efficiency. As an example, capsule shells made from gelatin cost less than

half of those made from plant cellulose, plus production using animal

gelatin shells is often twice as efficient. The fillers and capsule produc-

tion aids Kirkman uses in our hypoallergenic line are the most inert

ingredients known and are selected so as not to contain known potential

allergens. In addition to the plant cellulose in the capsule shell, Kirk-

man uses non-allergen excipients such as silicon dioxide, various cellulose

gums,di-calciumphosphate,inulin(fromthechickoryroot),andL-leucine.

Vegetablegrademagnesiumstearatemaybeusedinminutequantitiesas

a lubricant when necessary.

Raw materials selected for Kirkman’s hypoallergenic line were selected

to be the purest available minimizing the content of heavy metal impuri-

ties such as lead, mercury, cadmium and aluminum. Other environmentalcontaminantsarealsoscreenedincludingpesticideandPCBresidues,and

bacterial and yeast levels are carefully monitored.

In formulating the hypoallergenic line, Kirkman used only one criteria:

providing the best non-allergen product line possible. Ingredient choice

and purity, plus the science behind those selections, were the only consid-

erations.Costandproductionefficiencieswerenotconsidered.Helping

the extremely sensitive individual was our primary goal.

What Have Been the Results of Individuals Using

Kirkman’s Hypoallergenic Line?

Individuals using the hypoallergenic product line have essentially elimi-

nated all sensitivities, allergies and reactions that had previously been an

issue. The response to these products has been phenomenal with physi-



34

cians and customers from all over the world continuing to compliment and

thank Kirkman for developing this line that was so very much needed in

the world of dietary supplements. Individuals exhibiting sensitivities and

allergies have benefited greatly from this product line.

It is Kirkman’s goal to offer a hypoallergenic version of all products

developed in the future. This product line is a significant breakthrough in

allowing extremely sensitive individuals to get the supplements they need

without worrying about additives, allergens or impurities.



35We have listed some ideas below that we compiled from our discussions

with parents. This is by no means the complete list. We encourage you to

experiment to find what works for you and your child.

Flavorfoodordrinks.(maple,cherryandstrawberry.)•Mix in orange juice•

Mix in lemonade•

Mix in red grape juice•Mix in pear juice•Mix in baby food prepared juices•Mix in Juicy Juice®•MixinV-8Splash®•Useyogurt•Usepudding•Usefruitsorbets•Try cocoa•TryHershey’s®syrup•

Try peanut butter, cashew butter or almond butter•

Make a fruit “smoothy” in a blender•Makeaproteindrink(riceorsoy)inablender•Mix in honey or jelly•Make popsicles that include the vitamins (especially good for the•SuperNu-Thera®powdersandliquids)

Put doses of the supplements in “rice crispy treats”•Sprinkle non-heat sensitive products on a pancake before flipping•Mix in ketchup and let the kids drag their French fries through it•Puttheproductsinscrambledeggs(afterthey’recooked)•Putproductsinspaghettisauce(afterit’sbeencooked)•

Hideproducts(especiallyliquids)in“boxdrinks”• IfyouuseCoromega®,addothersupplementstoit•Calcium,magnesium,othermineralsandFlax(EFA)canbeusedin•cooking and baking

Baby foods work great for hiding supplementsMix supplements in•Vance’sDari-Free™orothermilksubstitute

HOW TO GET YOU CHILDREN TO

TAKE NUTRITIONAL SUPPLEMENTS

Many of your children need to take numerous supplements at

once and at multiple times during the day. This becomes very chal-

lenging for the parents and, of course, the children. At Kirkman

we are asked regularly for ideas on how to administer the supple-

ments so that the children will take them.

There are many ways to help your child takenutritional supplements.



36

APPENDIX A

Step-by-Step Recap of Interventions

There is not an absolute regimen that one should follow when begin-ning biomedical and dietary interventions in sensitive individuals, but

there are some logical sequences that a parent can follow until guidance

by a specialty physician is in place.

The Top Three Interventions to Try

Without question, the top three include:

1)Improvingnutrition

2)GF/CFdiet

3)Improvingtheconditionofthegastrointestinaltract

These top three can actually be tried in any order and all physicians may

notagreeastowhichorderisdesirable.Sosteps1,2,and3couldinvolve

in any order:

Super Nu-Thera® or Nu-Thera®•Thegluten-free/casein-freediet•Probioticsand/ordigestiveenzymes(amulti-strainprobioticsuch•as Pro-Bio Gold™ or Multi-Flora Spectrum™ would be a good

start,inconjunctionwithEnZym-Complete/DPP-IVIIwithIsogest®

formula)

Next Possible Steps

If sleep is an issue, the interventions listed for sleep improvement could

be tried as described in the Sleep Issues section.

If the symptoms of an immune problem are present, several of the prod-

ucts for immune support can be tried.

If vision support is needed, cod liver oil could be tried.

The More Complicated Interventions

When it comes to behavioral issues or metabolic pathway irregularities

such as methylation, sulfation and detoxification, a specialist physician

is really needed to assess the situation. Many complicated intricacies of



37

physiology exist in this area , plus potential side effects must be moni-

tored.Amulti-vitamin/mineralsupplementwithhighB-6/magnesium

may have helped begin the process, but numerous other options are spe-

cific to the individual and require a medical examination and guidance.

Laboratory Testing

When you begin working with a specialized physician, he or she will

undoubtedly request laboratory tests that are specifically tailored to a

patient’sneeds.Examplesofthesetestsare:

• Urinarypeptides

• Urinaryorganicacids

• Foodallergypanel

• Plasmasulfate

• Stoolanalysis

• Toxicmetals

• Redbloodcellelements• Essentialfattyacids

• LymphocyteTH1/TH2

• Liverandkidneyfunction

• MyelinBasicProtein

• Ammonia

You probably won’t need all the tests, rather you may want to select

ones based on a medical evaluation.

Kirkman’s Customer Service Staff and TechnicalStaff Can Help

The journey through dietary and biomedical interventions is not an easy

one. Your doctor will be your main source of guidance as you progress.

Kirkman has been supporting parents on their journeys with their children

for decades. Please feel free to call our customer service or technical staff

if you need assistance .



38

NOTes



39

CustomerService(clockwisefromtopleft:Sonia,Kathy,Amy,Rhonda,Shirley,Melisa,Carrie,Kari-Jane,BethandRacheal.)

s u at www.kirkmana.om

6400SWRosewoodStreet

LakeOswego,Oregon97035

Telephone: (800)245-8282

(888)KIRKMAN

(503)694-1600

Fax: (503)682-0838

E-Mail:

Ordering: [email protected]:[email protected]

Technical Support: [email protected]

ServicioalClienteenEspanol:[email protected]

LineaDirectaenEspanol:(503)783-2714



40

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