AHHM Lecture Series:Pathology Meets the Future

and All That Jazz: AI, Regenerative Medicine and

You

Kim Solez, MD and Mallory Chipman

High impact education, changing human behavior, winning people over one by one with our messages about the arts, science, & medicine.

Are We Succeeding? Converted Anyone? Perhaps Patrick Pilarski!

Canada Research Chair in Machine Intelligence for RehabilitationAssistant Professor, Div. of Physical Medicine and Rehabilitation, Dept. of Medicine, Faculty of Medicine and Dentistry, University of AlbertaAdjunct Assistant Professor, Dept. of Computing ScienceAdjunct Assistant Professor, Faculty of Rehabilitation Medicine• Trained with Rich Sutton in Computing Science• Patrick M. Pilarski is also a well known poet who has served as an

organizer for the Edmonton Poetry Festival and as the Vice President for the League of Canadian Poets.

• On January 19, 2016 he was part of our first ever Futureand All That Jazz performance at Rouge Lounge. When he found out our second set was entirely improvisational and long he had some reservations about format.• On August 18, 2016 a friend of his was in our audience forour Vortex Jazz Club performance in London, UK, and greatlyenjoyed it. Now Patrick is a big fan of what we are doing!

In the beginning (before Mallory Chipman) the boring long flat part of the exponential change/innovation curve had some blips.

Kim Solez Career Timeline• MD With Honour and With Distinction in Research, University of Rochester,

Borden Award for Best Medical Research done by a member of the Graduating Class (Medical School) 1972

• Francis S. Schwentker Award for Best Research done by a Johns Hopkins Hospital House Officer, 1974

• First Banff Conference on Transplant Pathology 1991• National Kidney Foundation (U.S.) support of cyberNephrology Center

1997- 2007• International Society of Nephrology support of Informatics Commission

1997-2007• William Boyd Lectureship 2002, Canadian Association of Pathologists.• Researcher of the Year, Capital Health Authority, 2005.• National Kidney Foundation (US) Distinguished International Medal, 2009• Technology and Future of Medicine course begins 2011• Tier 1 Clinical Mentoring Award, University of Alberta Faculty of Medicine

and Dentistry, 2016 https://www.youtube.com/watch?v=j03j1JMlYg0• Teaching technology and the future of medicine to entire first year medical

student class directly begins in 2016.

Students Key to 1974 Award!

Francis S. Schwentker Award for Best Research done by a Johns Hopkins Hospital House Officer, 1974 In presenting the award Chair of Medicine Victor McKusick read the full names of all coauthors saying “Since Dr. Solez was a busy house officer I am sure the other authors did considerable work.”Solez, K., Kramer, E.C., and Heptinstall, R.H.:  The pathology of acute renal failure:  Leukocyte accumulation in the vasa recta.  Am. J. Pathol. 74:31a, 1974Solez, K., Kramer, E.C., Fox, J.A., and Heptinstall, R.H.: Medullary plasma flow and intravascular leukocyte accumulation in acute renal failure. Kidney Int. 6:24-37, 1974.Solez, K., Miller, M., Quarles, P.A., Finer, P.M., and Heptinstall, R.H.: Experimental papillary necrosis of the kidney. IV. Medullary plasma flow. Am. J. Pathol. 76:521-528, 1974.Solez, K., Fox, J.A., Miller, M., and Heptinstall, R.H.: Effects of indomethacin on renal inner medullary plasma flow. Prostaglandins 7:91-97, 1974.

“Solezocytes”in vasa rectain acute tubular injury

Dr. Jennifer Nuovo

Dr. Pamela Quarles (Oberlin College, 1975, Winter Term ’73)Became a psychiatrist in Alexandria, Virginia. Was the daughter

of legendary black historian Benjamin Quarles (center of 1992 image)https://en.wikipedia.org/wiki/Benjamin_Arthur_Quarles .

Oberlin College1975, Winter Term 1973,+ Summer

Elizabeth (Beth) Kramer “Are you still doing that old stuff?”

Became a nursing leader. Five years later she came back to see me. I told her what I was up to, and she said “Are you still doing that old stuff?” This embarrassing remark motivated me to become an innovator, to step out of the box, to do unexpected things.

Oberlin College, 1974Winter Term ’73 + Summer

Elizabeth (Beth) Kramer “Are you still doing that old stuff?”

This drive to innovate led me to found and direct a course on Technology and the Future of Medicine, which talks about a future world in which: 1) machines become smarter than we are and

take over the future agenda of the world (The Technological Singularity), and

2) stem cell generated organs and organ repair offers a cure for most diseases.

These two new aspects of the future suggest two new disciplines of pathology:

1) Tissue Engineering Pathology, study of the abnormalities in stem cell generated organs, a discipline which helps to perfect regenerative medicine therapies (Good!)

2) Apocalyptic Pathology, study of the pathology of the elimination of the human species by sentient

machines who found us a nuisance (Bad! Theoretical only (we hope!), the human remains/artifacts left behind for robots to study after we meet our

demise!)

Technology Run Amuck Scenarios, Unfriendly AI & Nanotechnology Gone Wrong - Grey Goo – Not Appealing Lecture Subjects!

You Know Something About the Apocalypse The End of the World Through One of Robert Frost’s Best Known Poems.

In an anecdote he recounted in 1960, prominent astronomer Harlow Shapley claims to have inspired "Fire and Ice”. Shapley describes an encounter he had with Robert Frost in 1922 a year before the poem was published in which Frost, noting that Shapley was the astronomer of his day, asks him how the world will end. Shapley responded that either the sun will explode and incinerate the Earth, or the Earth will somehow escape this fate only to end up slowly freezing in deep space. Shapley was surprised at seeing "Fire and Ice" in print a year later, and referred to it as an example of how science can influence the creation of art, or clarify its meaning. (From Wikipedia)

Science Influences Art: Robert Frost’s “Fire and Ice” Inspired by a conversation with prominent astronomer Harlow Shapley

Acceptance. Share power. The AIs will not all be under our control. They will compete and cooperate with us just like other people, except with greater diversity and asymmetries We need to set up mechanisms (social, legal, political,

cultural) to ensure that this works out well Inevitably, conventional humans will be less important Step 1: Lose your sense of entitlement

Step 2: Include AIs in your circle of empathy

The Future and All That Jazz: Art Helps Convey Important Messages of Science.

We made up a new word: “Suttonize”To Suttonize a situation is to promote a message of acceptance of diversity that insures everyone survives and prospers by building on each others’ strengths and working together, cooperating and including others in our circles of empathy as equals. “Showing sentient machines empathy.If this kindness survives, so will we!”

The Future and All That Jazz: Art Helps Convey Important Messages of Science.

We made up a new word: “Suttonize”To Suttonize a situation is to promote a message of acceptance of diversity that insures everyone survives and prospers by building on each others’ strengths and working together, cooperating and including others in our circles of empathy as equals. “Showing sentient machines empathy.If this kindness survives, so will we!”

The Future and All That Jazz: Art Helps Convey Important Messages of Science.