KBI Case Studies: Process Development
-
Upload
kbi-biopharma -
Category
Health & Medicine
-
view
149 -
download
3
Transcript of KBI Case Studies: Process Development
![Page 1: KBI Case Studies: Process Development](https://reader031.fdocuments.net/reader031/viewer/2022021919/58758b111a28ab901c8b5abd/html5/thumbnails/1.jpg)
KBI Case StudiesProcess Development
Improving Titer
Toolbox for Product Quality Optimization
High Throughput Process Development Using Microbioreactors
High Cell Density Process
![Page 2: KBI Case Studies: Process Development](https://reader031.fdocuments.net/reader031/viewer/2022021919/58758b111a28ab901c8b5abd/html5/thumbnails/2.jpg)
Improving Titer
Toolbox for Product Quality Optimization
High Throughput Process Development Using Microbioreactors
High Cell Density Process
KBI Case StudiesProcess Development
![Page 3: KBI Case Studies: Process Development](https://reader031.fdocuments.net/reader031/viewer/2022021919/58758b111a28ab901c8b5abd/html5/thumbnails/3.jpg)
KBI Case Studies | Process Development
Improving Titer
Objective:
● Increase titer compared to the process transferred to KBI
Outcome:
● Through feed and supplement optimization, KBI routinely improves titer several fold compared to the process transferred to KBI
![Page 4: KBI Case Studies: Process Development](https://reader031.fdocuments.net/reader031/viewer/2022021919/58758b111a28ab901c8b5abd/html5/thumbnails/4.jpg)
KBI Case Studies | Process Development
Improving Titer
![Page 5: KBI Case Studies: Process Development](https://reader031.fdocuments.net/reader031/viewer/2022021919/58758b111a28ab901c8b5abd/html5/thumbnails/5.jpg)
Improving Titer
Toolbox for Product Quality Optimization
High Throughput Process Development Using Microbioreactors
High Cell Density Process
KBI Case StudiesProcess Development
![Page 6: KBI Case Studies: Process Development](https://reader031.fdocuments.net/reader031/viewer/2022021919/58758b111a28ab901c8b5abd/html5/thumbnails/6.jpg)
KBI Case Studies | Process Development
Objective:
● Modify product quality to match a predetermined target through use of a toolbox of strategies around raw materials and process conditions
Outcome:
● KBI has a toolbox of strategies to optimize galactosylation, fucosylation, mannonse-5, glycation, and charge distribution
Toolbox for Product Quality Optimization
![Page 7: KBI Case Studies: Process Development](https://reader031.fdocuments.net/reader031/viewer/2022021919/58758b111a28ab901c8b5abd/html5/thumbnails/7.jpg)
KBI Case Studies | Process Development
Toolbox for Product Quality Optimization
![Page 8: KBI Case Studies: Process Development](https://reader031.fdocuments.net/reader031/viewer/2022021919/58758b111a28ab901c8b5abd/html5/thumbnails/8.jpg)
Improving Titer
Toolbox for Product Quality Optimization
High Throughput Process Development Using Microbioreactors
High Cell Density Process
KBI Case StudiesProcess Development
![Page 9: KBI Case Studies: Process Development](https://reader031.fdocuments.net/reader031/viewer/2022021919/58758b111a28ab901c8b5abd/html5/thumbnails/9.jpg)
KBI Case Studies | Process Development
Objective:● Demonstrate microbioreactor scalability and shorten
process development timeline by using microbioreactorsOutcome:● KBI has demonstrated scalability of ambr microbioreactors
and has integrated this technology in process development workflow. Use of microbioreactors can reduce process development timeline by 1 – 2 months.
High Throughput Process Development Using Microbioreactors
![Page 10: KBI Case Studies: Process Development](https://reader031.fdocuments.net/reader031/viewer/2022021919/58758b111a28ab901c8b5abd/html5/thumbnails/10.jpg)
KBI Case Studies | Process Development
High Throughput Process Development Using Microbioreactors
Days Days
Via
ble
Cel
l Den
sity
(10
^6 c
ells
/mL)
Via
bilit
y (%
)
![Page 11: KBI Case Studies: Process Development](https://reader031.fdocuments.net/reader031/viewer/2022021919/58758b111a28ab901c8b5abd/html5/thumbnails/11.jpg)
Improving Titer
Toolbox for Product Quality Optimization
High Throughput Process Development Using Microbioreactors
High Cell Density Process
KBI Case StudiesProcess Development
![Page 12: KBI Case Studies: Process Development](https://reader031.fdocuments.net/reader031/viewer/2022021919/58758b111a28ab901c8b5abd/html5/thumbnails/12.jpg)
KBI Case Studies | Process Development
Objective:● Develop high cell density processes using ATFOutcome:● KBI has developed high cell density processes (>100
million cells/mL) with improved viability and product quality profiles.
High Cell Density Process
![Page 13: KBI Case Studies: Process Development](https://reader031.fdocuments.net/reader031/viewer/2022021919/58758b111a28ab901c8b5abd/html5/thumbnails/13.jpg)
KBI Case Studies | Process Development
High Cell Density Process
![Page 14: KBI Case Studies: Process Development](https://reader031.fdocuments.net/reader031/viewer/2022021919/58758b111a28ab901c8b5abd/html5/thumbnails/14.jpg)
www.kbibiopharma.com
PO Box 155791101 Hamlin RoadDurham, NC 27704
Tel: +1 919 479 9898
Contact Us
![Page 15: KBI Case Studies: Process Development](https://reader031.fdocuments.net/reader031/viewer/2022021919/58758b111a28ab901c8b5abd/html5/thumbnails/15.jpg)