Karos Pharmaceuticals, Inc.; Termination Request Letter ... · nift code: pnccus33 outing #...

$: Karos Pharmaceuticals, Inc.; Termination Request Letter ... · nift code: pnccus33 outing # 041000124 ccount # 4611192601 ame: american radiolabeled chemicals, inc. '\nk: pnc bank$
lf ~~~}2:~ 18 July 2017

Licensing Assistant Section Nuclear Materials Safety Branch U.S. Nuclear Regulatory Commission, Region I 2100 Renaissance Boulevard, Suite 100 King of Prussia, PA 19406-2713

Dear Sir or Madam,

I am writing to formally request that the radioisotope license for Karas Pharmaceuticals, No. 31-31441-01, Docket No. 030-38452, be terminated. Karas is transitioning out of its pre-clinical research and is currently in the process of closing its laboratory site in New Haven.

At this date, all radiochemical material and waste has been removed and disposed of by Chase Environmental Group, 11450 Watterson Court, Louisville, KY. In addition, our Tri-Garb scintillation counter has been removed for disposal by Radiac Research Corp, 261 Kent Avenue, Brooklyn, NY. Therefore, we no longer have any radiochemical material or radiochemical sources on site. All corresponding documentation for both our waste disposal and removal/ disposal of the scintillation counter has been enclosed with this letter.

All equipment and the limited laboratory space where radiochemical material was used and/or stored has been surveyed for contamination and shown to be at or below background. Maps of the areas surveyed as well as the survey results are enclosed.

During the course of research at Karas, no volatile radiochemical materials were used, nor was any radiochemical material and/or waste disposed of down the drain or into the environment.

I am very proud to report that no spills or accidents with radiochemical materials occurred during the 6 years Karas held a license with the NRG.

Documentation for radiochemical orders, inventory lists, waste removal/ disposal reports and manifests, as well as lab survey reports are enlcosed with this letter for your review.

Unfortunately, I have been informed that the biology group is being closed down before the transition from pre-clinical is complete. Therefore, I may be only avaible for correspondence from Karas until mid- to possibly late August. Please provide guidance on how I may transfer the RSO responsibilties to other team members in case the timing to process our request for license termination exceeds my employment at Karas.

5 Science Park• New Haven CT 06511-1989 USA H 203-535-0540 • Fax 203-891-5156

I-·->·

I have been told that my company email address will be available for a while after I leave and you may contact me at [email protected]

Our current mailing address is:

Karos Pharmaceuticals 5 Science Park New Haven, CT 06511

We will contact you when our biology group has offically been terminated. Subsequently, you can forward any written correspondence to our corporate office:

New Leaf Venture Partners 7 Times Square Suite 3502 New York, NY 10036

Thank you for your attention and assistance with this transition.

With best regards,

~~~ Robert Aiello, PhD Director of Biology Karos Pharmaceuticals

5 Science Park• New Haven CT 06511-1989 USA H 203-535-0540 •Fax 203-891-5156

NRC FORM 314 (02-2017)

U.S. NUCLEAR REGULATORY COMMISSION APPROVED BY OMB: NO. 3150-0028 EXPIRES: 02/29/2020

10 CFR 30.360)(1); 40.420)(1); 70.380)(1); and 72.54(k)(5)(1)(1) CERTIFICATE OF DISPOSITION

OF MATERIALS

Estimated burden per response to comply with this mandatory collection request: 30 minutes. This submittal is used by NRG as part of the basis for its determination that the facility is released for unrestncted use. Send comments regarding burden estimate to the FOIA, Privacy, and Information Collections Branch (T-5 F53), U.S. Nuclear Regulatory Commission, Washington, DC 20555-0001, or by e-mail to [email protected], and to the Desk Officer, Office of Information and Regulatory Affairs, NEOB-10202, (3150-0026), Office of Management and Budget, Washington, OC 20503. If a means used to impose an information collection does not display a currently valid OMS control number, the NRC may not conduct or sponsor, and a person is not required to respond to, the information collection.

LICENSEE NAME AND ADDRESS LICENSE NUMBER DOCKET NUMBER

~OS ftiAR.\'nl\CU./i\CAL~ '-3 $( IQVfE P/-\1<'.X .. 3 \-3• 44 l-01 030··3~4'52

tJ~W rl1\'\1°'1) c r Ob'ill LICENSE EXPIRATION DATE

Tu~ 30 / 2,02_.i

D This license has expired.

A. LICENSE STATUS (Check the appropriate box)

rE.._ This license has not yet expired; please terminate it.

• B. DISPOSAL OF RADIOACTIVE MATERIAL (Check the appropriate boxes and complete as necessary. If additional space is needed, provide attachments)

The licensee, or any individual executing this certificate on behalf of the licensee, certifies that:

D 1. No radioactive materials have ever been procured or possessed by the licensee under this license.

I'll" 2. All activities authorized by this license have ceased, and all radioactive materials procured and/or possessed by the licensee ~ under this license number cited above have been disposed of in the following manner.

D a. Transfer of radioactive materials to the licensee listed below:

~ b. Disposal of radioactive materials:

D 1. Directly by the licensee:

D 2. By licensed disposal site:

i2'.i3. Bywastecontractor: AU. RAD\0(,ti()'Ylll.A\,, 'i'\1A--f\;;1ZlAl,S' OAJ WASIE Wf\'$ flEtnCVt:J> c~ j)l~PCS$ D(:. B'f CrtASt SJvl~CNn1t-,VTM. t~Zc.\;~ 1•'450 WAITC17.SCtv coc1z.r, L..OV\SVH.A.~, KY i-~O"lqq l5C:t) :2(,'1-i455

D c. All radioactive materials have been removed such that any remaining residual radioactivity is within the limits of 10 CFR Part 20, Subpart E, and is ALARA.

C. SURVEYS PERFORMED AND REPORTED ~ 1. A radiation survey was conducted by the licensee. The survey confirms:

~a. the absence of licensed radioactive materials

D b. that any remaining residual radioactivity is within the limits of 10 CFR 20, Subpart E, and is ALARA.

l>ZJ 2. A copy of the radiation survey results:

~a. is attached; or Db. is not attached (Provide explanation); or D c. was forwarded to NRC on:

D 3. A radiation survey is not required as only sealed sources were ever possessed under this license, and Date

D a. The results of the latest leak test are attached; and/or 0 b. No leaking sources have ever been identified.

The person to be contacted regarding the information provided on this form:

NAME TITLE

Mail all future correspondence regarding this license to:

t-,'f:.W l.Cf'F v'GtJiVll.C

TELEPHONE (Include Area Code) E-MAIL ADDRESS

.lc>?-~35_ 0s40 1· .. a·1ello G K.oros p naror~ . u-'111

SClvA~c, svrTE 3502., Nt;.'"W'iOZ~,, IJ'f •003b

C. CERTIFYING OFFICIAL I CERTIFY UNDER PENAL TY OF PERJURY THAT THE FOREGOING IS TRUE AND CORRECT

PRINTED NAME AND TITLE SIGNATURE DATE

WARNING: FALSE STATEMENTS IN THIS CERTIFICATE MAY BE SUBJECT TO CIVIL AND/OR CRI~ PENALTIES. NRC REGULATIONS REQUIRE THAT SUBMISSIONS TO THE NRC BE COMPLETE AND ACCURATE IN ALL MATERIAL RESPECT. 18 U.S.C. SECTION 1001 MAKES IT A CRIMINAL OFFENSE TO MAKE A WILLFULLY FALSE STATEMENT OR REPRESENTATION TO ANY DEPARTMENT OR AGENCY OF THE UNITED STATES AS TO ANY MATTER WITHIN ITS JURISDICTION.

NRC FORM 314 (02-2017)

lfKAROS LABORATORY ISOTOPE RECORD - ORDERS

ORDER ORDERED BY VENDOR MATERIAL

ISOTOPE AMT #of DATE WIPE DATE DESCRIPTION ORDERED CONTAINERS REC'D CHECK*

7/19/11 RJ Aiello American Radiolabeled

L-Tryptophan 14C 50µCi 1 7/22/1 OK Chemicals


5-3-L-Tryptophan 3H 250µCi 1 7/29/11 OK Chemicals

8/8/11 P Bourassa American Radiolabeled

5-3-L-Tryptophan 3H 250µCi 1 8/11/11 OK Chemicals



8/18/11 RJ Aiello Perkin Elmer 5-3-L-Tryptophan 3H lmCi 1 8/23/11 OK



1/9/12 RJ Aiello Moravek Biochemicals A-Methyl-14C-L- 14C 50µCi 1 1/10/12 OK

Tryptophan

1/19/12 RJ Aiello Perkin Elmer 5-Hydroxy-3H- 3H 250µCi 1 1/20/12 OK

Tryptamine

1/20/12 W Zavadoski Perkin Elmer L-[5-3H]- 3H lmCi 1 1/23/12 OK

Tryptophan

8/2/12 W Zavadoski Perkin Elmer L-[5-3H]- 3H lmCi 1 8/7/12 OK

Tryptophan

9/25/12 W Zavadoski Perkin Elmer Hydroxy tryptamine 14C 50µCi 1 9/26/12 OK Binoxalate, 5-2-14C

1/25/13 W Zavadoski Perkin Elmer L-[5-3H] 3H lmCi 1 1/28/13 OK

Tryptophan

3/12/13 W Zavadoski Perkin Elmer 2-[1,2 -3H(N)]- 3H 250µCi 1 3/13/13 OK

Deoxy D Glucose *Limit for external package contamination for beta emitters is a net of 220 dpm/cm2• Assuming a 10% removal efficiency, this is 6600 net dpm for a 300 cm2 wipe test. Assuming 50% counting efficiency, 3300 cpm is the approximate net cpm limit for a raw wipe test result.

lfKAROS LABORATORY ISOTOPE RECORD - ORDERS

ORDER ORDERED VENDOR MATERIAL ISOTOPE AMT #of DATE WIPE DATE BY DESCRIPTION ORDERED CONTAINERS REC'D CHECK*

5/15/13 P Bourassa Perkin Elmer L-[5-3H] 3H lmCi 1 5/16/13 OK

Tryptophan

8/12/13 RJ Aiello American Radiolabeled Radiolabeled 14C lmCi 1

10 vials@ OK

Chemicals KAR5202 lOOµCi ea

10/23/13 RJ Aiello Perkin Elmer L-[5-3H] 3H lmCi 1 10/24/13 OK

Trvptophan

4/14/15 RJ Aiello Perkin Elmer L-[5-3H] 3H lmCi 1 4/15/15 OK

Tryptophan

6/21/16 P Bourassa American Radiolabeled

[ 1-14C] Oleic Acid 14C 50µCi 1 6/22/16 OK Chemicals

7/28/16 J Dubins Perkin Elmer Methyl- [3H] 3H 250µCi 1 7/29/16 OK Thymidine

*Limit for external package contamination for beta emitters is a net of 220 dpm/cm2• Assuming a 10% removal efficiency, this is 6600 net dpm for a 300 cm2 wipe test. Assuming 50% counting efficiency, 3300 cpm is the approximate net cpm limit for a raw wipe test result.

··ML AMERICAN RADIOLABELED CHEMICALS, INC. 101 ARC DRIVE

SAINT LOUIS, MO 63146-3506

INVOICE PHONE: TOLL FREE: FAX: EMAIL: FED TAX ID:

I I

(314) 991-4545 (800) 331-6661 (314) 991-4692 [email protected] 43-1296541

INVOICE NO: 37073

INVOICE DATE: 07/19/11. BILL TO: 065114

KAROS PHARMACEUTICALS, INC. 5 SCIENCE PARK NEW HAVEN, CT 06511

SHIP TO:


TERMS P.O. NUMBER KAR072011

SHIP VIA FEDERAL EXP.

F.O.B. ST. LOUIS Net 30 Days

ATALOGNO. PRODUCT DESCRIPTION

QORD 1

QSHP 1 50uCi TRYPTOPHAN, L-[SIDE CHAIN

1-14C] 1899.00

I reci:l '1 -.ll- \ 1 VI f>(L ti-- 'l~:l~ -H-1

ATTN: R. AIELLO

I son Placing Order ROBERT AIELLO Phone # 203 535 0540

'IRE TRANSFER (USD): NIFT CODE: PNCCUS33 OUTING # 041000124 CCOUNT # 4611192601 AME: AMERICAN RADIOLABELED CHEMICALS, INC. '\NK: PNC BANK

S•h A VE & WOOD STREET

WIRE TRANSFER (EUR): SWIFT CODE: CITIDEFF BANK ID CODE (BIC): PNCCUS33 ACCOUNT# DE43502109004113B17009 NAME: AMERICAN RADIOLABELED CHEMICALS, INC. COMMENT: MULTICURRENCY ACCOUNT 71800001000013 BANK: CITIBANK FRANKFURT- EURO CLEARING

Subtotal

SHIPPING/HNDL<~ DRY ICE HAZARDOUS

Total

U.S. DOLLARS

1899.00

1899.00

60.00 35.00 0.00

1994.00

AMERICAN RADIOLABELED CHEMICALS, INC. 101 ARC DRIVE



I I

(314) 991-4545 (800) 331-6661 (314) 991-4692 [email protected] 43-1296541

INVOICE NO: 87187 INVOICE DATE:

07/28/11 BILL TO: 065114


SHIP TO:

KAROS PHARMACEUTICALS 5 SCIENCE PARK NEW HAVEN, CT 06511

TERMS P.O. NUMBER KAR072711



:ATALOGNO. PRODUCT DESCRIPTION

QORD 1

QSHP ;1-qT 244

ATTENTION: ROBERT

1 250uCi TRYPTOPHAN, L (5-3H]

~D m ~,( fbf. A--tr 8' AL5-~20H

~son Placing Order ROBERT Phone # 203 535 0540

WIRE TRANSFER (USO): SWIFT CODE: PNCCUS33 ROUTING # 041000124 ACCOUNT# 4611192601 NAME: AMERICAN RADIOLABELED CHEMICALS, INC. BANK: PNC BANK

5th A VE & WOOD STREET PJTT~RIJRC:H PA 1c;???-?707

WIRE TRANSFER (EUR): SWIFT CODE: CITIDEFF BANK ID CODE (BIC): PNCCUS33 ACCOUNT # DE43502109004113817009 NAME: AMERICAN RADIOLABELED CHEMICALS, INC. COMMENT: MULTI CURRENCY ACCOUNT 71800001000013 BANK: CITIBANK FRANKFURT - EURO CLEARING \TTY· FR A NKFI TRT

.·

229.00

Subtotal

SHIPPING/HNDL 1B DRY ICE HAZARDOUS

Total

U.S.DOLtARS

229.00

229.00

45.00 0.00 0.00

274.00



BILL TO: 065114

KAROS PHARMACEUTICALS. 5 SC I ENCE PARl< NEW HAVEH, CT 0651!

. 0. NUHBKP. : t'IJW808011 FEfJEF?i\f,

SHIP TO:

INVOICE NO:

INVOICE DATE:

'.}.

:ATALOG NO. PRODUCT DESCRIPTION

QO.Rfi C) S.hT l

Rruo <;sin/n \I\ AL ~ 6 - \( - \ l

rson Placing OrdE::! t'/;,'I'f<J(' /!, Phone n 20 s 5 0S40

WIRE TRANSFER (USD): SWIFT CODE: PNCCUS33 ROUTING# 041000124 ACCOUNT# 4611192601 NAME: AMERICAN RADIOLABELED CHEMICALS, INC. BANK: PNC BANK

5" A VE & WOOD STREET PITTSBURGH, PA 15222-2707

WIRE TRANSFER (EUR): SWIFT CODE: CITIDEFF BANK ID CODE (BIC): PNCCUS33 ACCOUNT # DE43502109004113817009 NAME: AMERICAN RADIOLABELED CHEMICALS, INC. COMMENT: MULTICURRENCY ACCOUNT 71800001000013 BANK: CITIBANK FRANKFURT- EURO CLEARING CITY: FRANKFURT


I I

(314) 991-4545 (800) 331-6661 (314) 991-4692 [email protected] 43-1296541


BILL TO:

::'.ATALOGNO.

'~. ! y

WIRE TRANSFER (USD): SWIFT CODE: PNCCUS33 ROUTING # 041000124 ACCOUNT# 4611192601

r:

'" l

NAME: AMERICAN RADIOLABELED CHEMICALS, INC. BANK: PNC BANK

S" AVE & WOOD STREET PITTSBURGH, PA 15222-2707


SHIP TO:

INVOICE NO:

INVOICE DATE:

PRODUCT DESCRIPTION

WIRE TRANSFER (EUR): SWIFT CODE: CITIDEFF BANK ID CODE (BIC): PNCCUS33 ACCOUNT# DE43502109004113B17009 NAME: AMERICAN RADIOLABELED CHEMICALS, INC. COMMENT: MULTI CURRENCY ACCOUNT 71800001000013 BANK: CITIBANK FRANKFURT - EURO CLEARING CITY: FRANKFURT


I I

(314) 991-4545 (800) 331-6661 (314) 991-4692 [email protected] 43-1296541

DELIVERY NUMBER 59938212

PAGE 1 /1

, dfkinElmer, Inc. 120 East Dedham St Boston, MA 02118 us www.perkinelmer.com SOLD TO:

KAROS PHARMACEUTICALS INC ACCOUNTS PAYABLE NEW HAVEN, CT 06511 us

IRS NO. 04-3361624

For Technical Da.

Ill I I I I Ill 1111111ii 4-A-2

DELIVER TO:

@@@ @@ @ @@ @ @@@ @ @ @ @ @ @ @@

59938212 SA.P l

KAROS PHARMACEUTIL.<iL 5 SCIENCE PARK NEW HAVEN, CT 06511 us

ISOTOPES: PO/NONE NO LABEL TI N/A H-3 0.037000 GBq/1.000000 rnCi ATIN: ROBERT AIELLQ

1505870444 I KAR082212011 ORDER NUMBER I CUSTOMER P.O. NUMBER

SHIP TERMS I VIA DESTINATION PO

SHl~PING POINT BOS 120 East Dedham St

CUSTOMER NUMBER

1046115

SHIPMENT TECH REP CSR INSPECTOR

ENTRY DATE

22-AUG-11

COMPLETE I PARTIAL SAP INTER x -SCHEDULED DATE SHIPPING DATE

22-AUG-11 22-AUG-11

=

AR NUMBER TAX REN LOCATION I CLASS

PKG.

DI

SALES CLASS

LINE QUANTITY QUANTITY PART NUMBER DESCRIPTION PACKAGE I

LOT/SERIAL NO. ORDERED SHIPPED

1 1 NET782001MC

L

TRYPTOPHAN, L-[5-3H]-

.1. H L VCMJM e:. [j 11 ~l)._,/\..c/Affi(.,)

R\2lJO g/23/u ~nA<... \:l:- ~-~3-U - I

1UESTIONS REGARDING THIS ORDER CALL: 8 0 0- 7 6 2 - 4 0 0 0 ~~OTOPES: H-3 D.0.T LABEL: NO TOTAL ACT: TOTAL ACT:

LABEL 0.037000 1.000000

GBq mCi

4-A-2 TRANS. INDEX:N/A

1188233 1 PACKING LIST

SIZE NUMBER

OOlmCi 37MBq

663993/l




(314) 991-4545 (800) 331-6661 (314) 991-4692

I I

[email protected] 43-1296541

INVOICE NO: 87926

INVOICE DATE: 10/04/11

BILL TO: 065114


SHIP TO:

KAROS PHARMACEUTICALS 5 SCIENCE PARK NEW HAVEN, CT 06511

TERMS P.O. NUMBER 0100411



:::ATALOGNO.

~-.c 255

PRODUCT DESCRIPTION

QORD 1

QSHP 1 50uCi TRYPTOPHAN, L-[SIDE CHAIN

1-14C]

~e0'P 10-b,, ll

SW I) lb tJ'-/_C. fix.. f'~Ka-Jf

I 0 <l.G-T 20 \\

ATTN: ROBERT AIELLO

~son Placing Order ROBERT AIELLO Phone # 203 535 0540

WIRE TRANSFER (USO): SWIFT CODE: PNCCUS33 ROUTING # 041000124 ACCOUNT# 4611192601 NAME: AMERICAN RADIOLABELED CHEMICALS, INC. BANK: PNC BANK

5th A VE & WOOD STREET PITTSBURGH, PA 15222-2707

WIRE TRANSFER (EUR): SWIFT CODE: CITIDEFF BANK ID CODE (BIC): PNCCUS33 ACCOUNT # DE43502109004113817009 NAME: AMERICAN RADIOLABELED CHEMICALS, INC. COMMENT: MULTI CURRENCY ACCOUNT 71800001000013 BANK: CITIBANK FRANKFURT - EURO CLEARING CITY: FRANKFURT

1899.00

Subtotal

SHIPPING/HNDL ~ DRY ICE HAZARDOUS

Total

U.S. DOLLARS

1899.00

1899.00

60.00 35.00 0.00

1994.00

PACKING LIST

Moravek Biochemicals 577 Mercury Lane Brea, CA 92821 Federal 10#95-3707141

YOUR CUSTOMER CODE IS:

Sold to: !Iii. \~slivery addr:: #

1

.. , r""°. KAROS PHARMACEUTICAL KAROS PHARMACEUTICAL ACCOUNTS PAYABLE 5 SCIENCE PARK NEW HAVEN, CT 06511

..... 5 SCIENCE PARK NEW HAVEN, CT 06511

ATTN:ROBERT J. AIELLO

Payment terms Ship via Invoice number Purchase order number

NET 30 Federal Express 20065 120103/REPL

Shipped Item number Quantity

1 1

MC1396 50UCI SODI

Sales tax

Description

A-M ETHYL[14C]-L-TRYPTOPHAN STANDARD OVERNIGHT/DRY ICE

Freight

Thank you for your order. Visit us on the web at www.moravek.com.

Unit price

Phone 1-800-44 7-0100 ·Facsimile 1-714-990-1824 ·e-mail [email protected]

Date

1/9/2012

Extended price

inical Data: www.perkinelmer.com/coa DELIVERY PAGE

,~s_35_0_15_1...o_6 ___ __.__1 __ 11 _ ____.I Pe:'kin E 1 r. .r· For the hdtter

1111111111111111111111

PerkinElmer, Inc. 549 Albany Street BOSTON MA 02118 USA

www. perkinelmer. com

SOLD TO/BILL TO:

KAROS PHARMACEUTICALS INC 5 SCIENCE PARK NEW HA VEN CT 06511 USA

IRS NO. 04-3361624

CUSTOMER NUMBER ENTRY DATE

100675019 01/19/2012

LINE QUANTITY QUANTITY PART NUMBER NO. ORDERED SHIPPED S/LOC, BIN TXT

1 1.000 1.000 NET1167250UC

SBRl

REZ' D zo 'J1\t...j ZCi2-

VI A1- U: I-·- \'Z - \

x 83507516

DELIVER TO: KAROS PHARMACEUTICALS INC ROBERT AIELLO 5 SCIENCE PARK NEW HA VEN CT 06511

XPOBlR USA

NO LABEL TIO.O

ISOTOPES:H-3 0.009250GBq I 0.250000mCi

ATTN: AIELLO, ROBERT

ORDER NUMBER CUSTOMER PO NUMBER

2360611 11812

SHIP TERMS F02 - FOB Factory - Prepay & Add ;

SHIPPING POINT US36 - Boston Shipping

SCHEDULED DATE SHIPPING DATE INSPECTOR PKG

01/19/2012 01/19/2012 BI

DESCRIPTION PACKAGE BATCH/SERIAL

UN NO, PSN, CLASS, PKG, TARIFF SIZE NUMBER

5-HYDROXY TRYPTAMINE, [3H]- 250UC 1576239/1

9250 kBq

ANY QUESTIONS REGARDING THIS ORDER CALL: (800) 762-4000

Total Gross Weight of Item: 0.020 KG/ r Total Gross Weight of Package: 3.571'

.. ,;~· ''.000 KG I 0.000 lbs.

DELIVERY

83509614

PerkinElmer, Inc. i49 Albany Street BOSTON MA 02118 USA


SOLD TO/BILL TO:

PAGE

1/1


IRS NO. 04-3361624

1> PerkinElmer·

For the Better

For Technical Data: www.perkinelmer.com/coa

1111111111111111111111

B 83509614

DELIVER TO: KAROS PHARMACEUTICALS INC RAD SAFETY I BILL ZAVADOSKI 5 SCIENCE PARK NEW HA VEN CT 06511

XPODlR USA

NO LABEL TI 0.0

ISOTOPES:H-3 0.037000GBq I l .OOOOOOmCi

ATTN: ZAVADOSKI, BILL


2361657 BILL012012

SHIP TERMS F02 - FOB Factory - Prepay & Add


CUSTOMER NUMBER ENTRY DATE SCHEDULED DATE SHIPPING DA TE INSPECTOR PKG

100675019 01/20/2012 01/20/2012 01/20/2012

LINE QUANTITY QUANTITY PART NUMBER DESCRIPTION PACKAGE

NO. ORDERED SHIPPED S/LOC, BIN TXT UN NO, PSN, CLASS, PKG, TARIFF SIZE

1 1.000 1.000 NET782001MC TRYPTOPHAN, L-[5-3H]- OOlMC

SBF2 37 MBq

ReVD cl.3~ 2.012

VI J'IL-14: / - 2. 3 - I l. - J


Total Gross Weight ofltem: 0.200 KG/ 0.441 lbs.

Total Gross Weight of Package: 3.100 KG/ 6.834 lbs.

Total Dry Ice weight: 2.000 KG I 4.409 lbs.

DI

BATCH/SERIAL

NUMBER

687230/1

~LIVERY

83834474

PAGE

111 f > For Technical Data: www.perkinelmer.com/coa

1111111111111111111111 PerkinElmer" For the Better A 83834474

PerkinElmer, Inc. DELIVER TO: KAROS PHARMACEUTICALS INC 549 Albany Street Robert Aiello BOSTON MA 02118 5 SCIENCE PARK USA NEW HA VEN CT 06511 www. perkinelmer. com XPODlR USA

SOLD TO/BILL TO: NO LABEL TI 0.0

KAROS PHARMACEUTICALS INC ISOTOPES:H-3 0.037000GBq I 1. OOOOOOmCi

5 SCIENCE PARK ATTN: AIELLO, ROBERT NEW HA VEN CT 06511

USA ORDER NUMBER CUSTOMER PO NUMBER

2494246 812012


IRS NO. 04-3361624 SHIPPING POINT US36 - Boston Shipping

CUSTOMER NUMBER ENTRY DATE SCHEDULED DATE SHIPPING DATE INSPECTOR PKG

100675019 08/02/2012 08/06/2012 08/06/2012 DI

LINE QUANTITY QUANTITY PART NUMBER DESCRIPTION PACKAGE BATCH/SERIAL

NO. ORDERED SHIPPED S/LOC, BIN TXT UN NO, PSN, CLASS, PKG, TARIFF SIZE NUMBER

1 1.000 1.000 NET782001MC TRYPTOPHAN, L-[5-3H]- OOlMC 1650430

SBF2 37MBq /1.000

R~c,:11 ~/ 1/12 Vt/'ct, # '8-1-1~-l


Total Gross Weight of Item: 0.200 KG/ 0.441 lbs.


Total Dry Ice weight: 1.000 KG 12.205 lbs.

DM;pVERY

83917865

PAGE

1/1 f > For Technical Data: www.perkinelmer.com/coa

1111111111111111111111 PerkinElmer· For the Better E 83917865

PerkinElmer, Inc. DELIVER TO: KAROS PHARMACEUTICALS INC 549 Albany Street Bill Zavadoski BOSTON MA 02118 5 SCIENCE PARK USA NEW HA VEN CT 06511 www. perkinelmer. com XPOlR USA


KAROS PHARMACEUTICALS INC ISOTOPES:C-14 0.001850GBq I 0.050000mCi

5 SCIENCE PARK ATTN: BROWN, LYNNE NEW HA VEN CT 06511


30246354 092512WZ


IRS NO. 04-3361624 SHIPPING POINT US36 - Boston Shipping


100675019 09/25/2012 09/25/2012 09/25/2012 AB



100 1.000 1.000 NEC225050UC HYDROXYTRYPTAMINE 050UC 1644774

SBRl BINOXALATE, 5-[2-14C]- 1850 kBq /1

~D q-2,b-il.

Vl~ ~ q_.."'-11.-\





·DELIVERY

85149178

PAGE

1/1 f > For Technical Data: www.perkinelmer.com/coa

1111111111111111111111 \/\.Pt_ 4:t \-'28-\3-:\ PerkinElmer·

PerkinElmer, Inc. .i49 Albany Street BOSTON MA 02118 USA


.. ... . •.

SOLD TO/BILL TO:


.. ..

IRS NO. 04-3361624


100675019 01/25/2013

LINE QUANTITY QUANTITY PART NUMBER NO .. ORDERED SHIPPED S/LOC, BIN TXT

100 1.000 1.000 NET782001MC

SBF3 .

R~:o a /ze/13 \llA1..- it l-28~l.3-)

For the B1 tter B 85149178

DELIVER TO: KAROS PHARMACEUTICALS INC Robert Aiello 5 SCIENCE PARK NEW HA VEN CT 06511

XPODlR· USA

NO LABEL TI 0.0


ATTN: BROWN, LYNNE


30255387 02513RA

SHIP TERMS F02 - FO~ Factory - Prepay & Add



01/2512013 01/25/2013 DI

DESCRIPTION PACKAGE BATCH/SERIAL

UN NO, PSN, CLASS, PKG, TARIFF SIZE NUMBER

;

1698265 TRYPTOPHAN, L-[5-3H]- OOlMC

37MBq /1.000


Total .Gross Weight ofitem: 0.200 KG/ 0.441 lbs.



D~LIVERY (

PAGE


1111111111111111111111 85230919 Perkin El mer· For the Better E 85230919

PerkinElmer, Inc. DELIVER TO: KAROS PHARMACEUTICALS INC 549 Albany Street William Zavadoski BOSTON MA 02118 5 SCIENCE PARK USA NEW HA VEN CT 06511 www. perkinelmer. com XPOlR USA


KAROS PHARMACEUTICALS INC ISOTOPES:H-3 0.009250GBq I 0.250000mCi

5 SCIENCE PARK NEW HA VEN CT 06511 USA

IRS NO. 04-3361624

CUSTOMER NUMBER

100675019

LINE QUANTITY QUANTITY

NO . ORDERED SHIPPED ..

100 1.000 1.000

ATTN: BROWN, LYNNE I \


30258991 031213WZ



ENTRY DATE SCHEDULED DATE SHIPPING DA TE INSPECTOR PKG

03/12/2013 03/12/2013 03/12/2013

PART NUMBER DESCRIPTION S/LOC, BIN TXT UN NO PSN, CLASS, PKG, TARIFF

NET328250UC DEOXY-D-GLUCOSE, 2-[l,2-3H (N)]-

SBF3

Rec'd V#JiC ~ 5-\3-J3

V\Ac ~ 3-13-)3 - \

PACKAGE SIZE

250UC

9250 kBq


AB

BATCH/SERIAL

NUMBER

1635065

/1




1/1 • PerkinElmer· lllllll II lllll Ill lllll J'erkinElmer, Inc. 549 Albany Street ~OSTON MA 02118

3A

www.perkinelmer.com

SOLD TO/BILL TO:


IRS NO. 04-3361624


100675019 05/15/2013

LINE QUANTITY QUANTITY PART NUMBER

NO. ORDERED SHIPPED S/LOC, BIN TXT

100 1.000 1.000 NET782001MC

SBF3

Rec'd 6-fh-13

V \AL -it. 5-lb-l3-I

For the Better A 85341866

DELIVER TO: KAROS PHARMACEUTICALS INC Patti Bourassa 5 SCIENCE PARK NEW HA VEN CT 06511

XPODlR USA

NO LABEL TI 0.0

ISOTOPES:H-3 0.037000GBq I l.OOOOOOmCi

ATTN: BROWN, LYNNE


30264113 051513PAB




05/15/2013 05/15/2013 DI

DESCRIPTION PACKAGE BATCH/SERIAL UN NO, PSN, CLASS, PKG, TARIFF SIZE NUMBER

TRYPTOPHAN, L-[5-3H]- OOlMC 1741702

37 MBq /1.000





101 ARC Drive Saint Louis, MO 63146-3506 Phone: (314) 991-4545 Toll-free: (800) 331-6661 Fax: (314) 991-4692

BILL TO:

'. 0, Nlil.fBEH } :~" ~:~ :· 3IH3

Bl::.. American Radiolabeled Chemicals, Inc.

s~· IP \ili FEDBRAL BlP.

SHIP TO:

INVOICE NO:

INVOICE DATE:

r ;'~ :t F~I\J(;r~ ,p-j:~ t· -r-~

l~lT H, \ ::•r C'J' 06511

}}',O,H,

ST, J',CUIS

INVOICE Email: [email protected]

Website: www.arc-inc.com Federal Tax ID: 43-1296541

08/1:3/13

1' F~ Ft f·:1 ~3 Net 30 DayE

AT ALOG NO. PRODUCT DESCRIPTION U.S. DOLLARS

Rec\d 8-t4- t3 ___ ,, ~~

/ .PCHI 062613r,:1

p, _son r1ae::1:-_• ()c-·1.·- ::: L:HHW :1;'--;J:-p :Ptllf?t's :j .;~ C ~- L; 3 t; , i) 5 4 -,

Limited Warranty At the time of shipment, many of ARC' s products are guaranteed for 30 days to be free from

defects in material and workmanship and to conform to the accompanying technical specifications and purity data. Exceptions to the 30-day policy include, but are not limited to, short-lived isotopes and products with

known stability issues.

i -ttuv i o

DHY JCF 3(J0,, "'r,,~~

- 0, Ot -- , (i()

I

• 1/1 Perkin El mere 1111111111111111111111 For the Belter A 85618248

PerkinElmer, Inc. DELIVER TO: KAROS PHARMACEUTICALS INC 549 Albany Street William Zavadoski ~OSTON MA 02118 5 SCIENCE PARK

!A NEW HA VEN CT 06511 www. perkinelmer. com XPODlR USA


KAROS PHARMACEUTICALS INC ISOTOPES:H-3 0.037000GBq I l .OOOOOOrnCi

5 SCIENCE PARK ATTN: BROWN, LYNNE NEW HA VEN CT 06511


30276257 102313WZ

')HIP TERMS F02 - FOB F2rtory - Prepay & Add '" ··--·~---- ·--· -.. ,., .. .,,._,._, -·- -'- ------ -~-..... ·- .. ....--..... ~···--~-~'"'~-- .. ~-

IRS NO. 04-3361624 I SHIPPING POINT US36 - Boston Shipping


100675019 10/23/2013 10/23/2013 10/23/2013 DI



100 1.000 1.000 NET782001MC TRYPTOPHAN, L-[5-3H]- OOlMC 1782173

SBF3 37MBq /1.000

Ra:}d to-~'-t-\3

V)Af_.. ~ \0-2'-}-\o





.Ll V hKY l'A.l.Jb

L 1 2847 111

.~

PerkinElmer· 1111111111111111111111

PerkinElmer, Inc. 549 Albany Street BOSTON MA 02118 USA

www.perkinelmer.com

SOLD TO/BILL TO:


IRS NO. 04-3361624


100675019 04/14/2015


NO. ORDERED SHIPPED S/LOC, BIN TXT

1 1.000 1.000 NET782001MC

SBF3

4-l5 -\5 tC :•· Iv

ft 4-\S-i5

For the Better A 86512847

DELIVER TO: KAROS PHARMACEUTICALS INC WILLIAM ZAVADOSKI 5 SCIENCE PARK NEW HAVEN CT 06511

XPODlR USA

NO LABEL TI 0.0

ISOTOPES:H-3 0.037000GBq I l.OOOOOOmCi

ATTN: EDWARDS, CHRISTINE

ORDER NUMBER . CUSTOMER PO NUMBER

3143971 04142015WZ




04114/2015 04/14/2015 DI

DESCRIPTION PACKAGE BATCH/SERIAL UN NO, PSN, CLASS, PKG, TARIFF SIZE NUMBER

TRYPTOPHAN, L-[5-3H]- OOlMC 1995844

37MBq /1.000




Total Dry Ice weight: 1.000 KG/ 2.205 lbs.

101 ARC Drive Saint Loui:.., MO 63146-3506 Phon!!: (314) 991-4545 Toll-free: (800) 331-6661 Fax: (314) 991-4692

BILL TO:

American Radiolabeled Chemicals, Inc.

SHIP TO:

INVOICE NO:

INVOICE DATE:

INVOICE Email: [email protected]

Website: www.arc-inc.com Federal Tax ID: 43-1296541

ATALOG NO. PRODUCT DESCRIPTION U.S. DOLLARS

Rec'd (o-22-~ lb

Vif'rt.· ·~ .G-:2-2·-ib - i

Limited Warranty At the time of shipment, many of ARC's products are guaranteed for 30 days to be free from

defects in material and workmanship and to conform to the accompanying technical specifications and purity data. Exceptions to the 30-day policy include, but are not limited to, short-lived isotopes and products with

known stability issues.

' DELIVE'.:1.Y PAGE


1111111111111111111111 ~;.52725 Perkin El mere

PerkinElmer Health Sciences, Inc. A9 Albany Street

BOSTON MA 02118 USA

www.perkinelmer.com

SOLD TO/BILL TO:


IRS NO. 04-3361624


100675019 07/28/2016


NO. ORDERED SHIPPED S/LOC BIN TXT

10 1.000 1.000 NET027 A250UC

SBRl

For the Better E 87252725

DELIVER TO: KAROS PHARMACEUTICALS INC JEFFREY DUBINS 5 SCIENCE PARK NEW HA VEN CT 06511

XPOlR USA

NO LABEL TI 0.0


ATTN: DUBINS, JEFFREY

.. ORDER NUMBER CUSTOMER PO NUMBER

3440588 07282016102




07/28/2016 07/28/2016

DESCRIPTION PACKAGE

UN NO, PSN, CLASS, PKG TARIFF SIZE

THYMIDINE, [METHYL-3H]- 250UC

9250 kBq

Rec1d 7 /2_q/Jb Vil>t.,, .ft 'l - 2 9 ,/-6

v PA~ CLtn.J

AB

BATCH/SERIAL

NUMBER

201608

/1





lfKAROS LABORATORY ISOTOPE RECORD - MASTER INVENTORY

DATE VENDOR

MATERIAL ISOTOPE ACTIVITY AMOUNT #of REC'D DESCRIPTION REC'D CONTAINERS

7/22/11 American Radiolabeled Chemicals L-Tryptophan 14C 55mCi/mMoL 50 uCi 1

7/29/11 American Radiolabeled Chemicals 5-3-L -Tryptophan 3H 20 Ci/mMoL 250 uCi 1

7/20/11 Long Island Scientific Equipment Source for

BA-133 1 1 Scintillation Counter

8/11/11 American Radiolabeled Chemicals L-Tryptophan 3H 20 Ci/mMoL 250 uCi 1


8/23/11 Perkin Elmer 5-3-L-Tryptophan 3H 17.9 1 mCi 1

Ci/mMoL


1/10/12 Moravek Biochemicals A-Methyl-L- 14C 56mCi/mMoL 50 uCi 1 Tryptophan

1/20/12 Perkin Elmer 5-Hydroxy 3H 82.8

250 uCi 1 Tryptamine Ci/mMoL

1/23/12 Perkin Elmer 5-L-Tryptophan 3H 17.9 1 mCi 1

Ci/mMoL

8/7/12 Perkin Elmer 5-L-Tryptophan 3H 21.1 1 mCi 1

Ci/mMoL

9/26/12 Perkin Elmer Hydroxy Tryptamine 14C 50.9 50 uCi 1

mCi/mMoL

1/28/13 Perkin Elmer 5-L -Tryptopha n 3H 0.037 GBq/ 1 mCi 1

mCi

lfKAROS LABORATORY ISOTOPE RECORD - MASTER INVENTORY

DATE VENDOR MATERIAL ISOTOPE ACTIVITY

AMOUNT #of REC'D DESCRIPTION REC'D CONTAINERS

0.0092S 3/13/13 Perkin Elmer Deoxy-D-Glucose 3H GBq/ 2SO uCi 1

0.2SmCi

S/16/13 Perkin Elmer S-L -Tryptopha n 3H 0.037 GBq/ 1 mCi 1

mCi

8/14/13 American Radiolabeled Chemicals KC0009 (KARS202) 14C so 1 mCi

10 vials of mCi/mMoL 100uCieach

10/24/13 Perkin Elmer S-L -Tryptopha n 3H 37 mBq/ mCi 1 mCi 1

4/1S/1S Perkin Elmer S-L-Tryptophan 3H 37 mBq/ mCi 1 mCi 1

6/22/16 American Radiolabeled Chemicals Oleic Acid 14c SSmCi/ SO uCi 1 mMoL

7/29/16 Perkin Elmer Methyl-Thymidine 3H 92SO kBq 2SO uCi 1

lfKAROS LABORATORY ISOTOPE RECORD - FINAL INVENTORY - June 2017

DATE VENDOR MATERIAL ISOTOPE ACTIVITY

AMOUNT 2012 2013 2014 2015 2016 2017 DISPOSAL AS REC'D REC'D WASTE

American 55mCi/

7/22/11 Radiolabeled L-Tryptophan 14C 50 uCi Storage Chemicals

mMoL 50uCi - 4Jan2013

Waste 50

American 5-3-L- 20 Ci/ 7/29/11 Radiolabeled Tryptophan

3H mMoL 250 uCi Storage

Chemicals 250uCi - 4Jan2013

Waste 250

American 20

8/11/11 Radiolabeled L-Tryptophan 3H 250 uCi Storage 5 5 5 Chemicals Ci/mMoL 245uCi - 4Jan2013

5uCi - 29Jun2017 Waste 245 5

American 55mCi/

8/19/11 Radiolabeled L-Tryptophan 14C mMoL 50 uCi Storage

Chemicals 50uCi - 4Jan2013

Waste 50

8/23/11 Perkin Elmer 5-3-L- 3H 17.9

1 mCi Storage 445 Tryptophan Ci/mMoL 555uCi - 4Jan2013;

445uCi - 16Jan2014 Waste 555 445

American 55mCi/ 14uCi - 9Jan2015

10/5/11 Radiolabeled L-Tryptophan 14C mMoL

50 uCi Storage 50 50 36 36 36 36uCi - 29Jun2017 Chemicals

Waste 14 36

1/10/12 Moravek A-Methyl-L- 14C 56mCi/ 50 uCi Storage 44.5 44.5 44.5 44.5 44.5 Biochemicals Tryptophan mMoL 5.5uCi - 4Jan2013

44.5uCi - 29Jun2017 Waste 5.5 44.5

~ KAROS - Pharmaceuticals LABORATORY ISOTOPE RECORD - FINAL INVENTORY - lune 2017

DATE VENDOR MATERIAL I ISOTOPE ACTIVITY AMOUNT 2012 2013 2014 2015 2016 2017 DISPOSAL AS

REC'D REC'D WASTE

1/20/12 Perkin Elmer 5-Hydroxy

I 3H I 82.8

I 250 uCi I Storage I 249 I 249 I 249 I 249 I 249 Tryptamine Ci/mMoL I I luCi - 4Jan2013

249uCi - 29Jun2017 Waste I 1 I I I I I 249

1/23/12 I Perkin Elmer I 5-L-Tryptophan I 3H I 17.9 1 mCi Storage I 255

Ci/mMoL I I I I I I 745uCi - 4Jan2013 255uCi - 16Jan2014

Waste I 745 I 255

8/7/12 l Perkin Elmer I 5-L-Tryptophan I 3H I 21.1 1 mCi Storage I 405

Ci/mMoL I I I I I I 595uCi - 4Jan2013 405uCi - 16Jan2014

Waste 595 405

9/26/12 I Perkin Elmer I Hydroxy 14( 50.9 50 uCi Storage 48 48 I 37 I 37 I 37

Tryptamine mCi/mMoL I I 2uCi - 4Jan2013 11uCi - 9Jan2015

Waste I 2 I 11 I I I 37 I 37uCi - 29Jun2017

1/28/13 I Perkin Elmer I 5-L-Tryptophan I 3H I 0.037 GBq/ mCi

1 mCi Storage

Waste I I 1mCi I I I I I lmCi -16Jan2014

0.00925 3/13/13 I Perkin Elmer I Deoxy-D-Glucose I 3H I GBq/

I 250 uCi I storage I

I

30

I

30

I

30

:

30

I I 220u0 -16Jan2014 0.25mCi

220 30 30uCi - 29Jun2017

Waste

lfKAROS LABORATORY ISOTOPE RECORD - FINAL INVENTORY - June 2017

DATE VENDOR MATERIAL ISOTOPE ACTIVITY AMOUNT 2012 2013 2014 2015 2016 2017

DISPOSAL AS REC'D REC'D WASTE

American 50

8/14/13 Radiolabeled KC0009 (KAR5202) 14( mCi/mMoL

1 mCi Storage 931 929 929 929 69uCi - 16Jan2014 Chemicals 2uCi - 9Jan2015

Waste 69 2 929 929uCi - 29Jun2017

10/24/13 Perkin Elmer 5-L-Tryptophan 3H 37 mBq/ 1 mCi Storage 880 752

mCi 120uCi - 16Jan2014 128uCi - 9Jan2015

Waste 120 128 752 752uCi - 29Jun2017

4/15/15 Perkin Elmer 5-L-Tryptophan 3H 37 mBq/ 1 mCi Storage 783 781

mCi lmCi - 29Jun2017

Waste 217 2 781

American 55mCi/

6/22/16 Radiolabeled OleicAcid 14C mMoL

50 uCi Storage 2.5 Chemicals 50uCi - 29Jun2017

Waste 47.5 2.5

7/29/16 Perkin Elmer Methyl-Thymidine 3H 9250 kBq 250 uCi Storage 250

250uCi - 29Jun2017

Waste 250

Long Island Source for 7/20/11 Scientific Scintillation BA-133

Eauioment Counter

"KAR0S «::> PHAAMAC:IUT'ICALS

LABORATORY ISOTOPE RECORD - 2012 Year End INVENTORY

DATE: i CJ \"Jet.. :l0i2.... AUDITOR: ~l\l .&ju\!A~S~

ISOTOPE MATERIAL

VIAL# DESCRIPTION

3H S-3-L -Tryptophan 7-29-11

3H L-Tryptophan 8-11-11

3H S-3-L-Tryptophan 8-23-11

3H S-Hydroxy 1-20-12

Trvotamine

3H S-L -Tryptopha n 1-23-12

3H S-L -Tryptopha n 8-7-12

14c L -Tryptopha n 7-22-11

14c L-Tryptophan 8-19-11

14c L-Tryptophan 10-S-11

14c A-Methyl-L -1-10-12

tryptoohan

14c Hydroxy Tryptamine 9-26-12

AMOUNT REC'D

2SO uCi

2SO uCi

1 mCi

2SO uCi

1 mCi

1 mCi

SO uCi

SO uCi

SO uCi

SO uCi

SO uCi

TOTALS

STORED WASTE to be Disposed 4Jan 2013

2498.50 uCi

2011 AMOUNT AMOUNT in START AMT in WASTE STORAGE

2SO uCi 2SO uCi

2SO uCi 24S uCi S uCi

1 mCi SSS uCi 44S uCi

2SO uCi 1 uCi 249 uCi

1 mCi 74S uCi 2SS uCi

1 mCi S9S uCi 40S uCi

SO uCi SO uCi

SO uCi SO uCi

SO uCi SO uCi

SO uCi S.S uCi 44.S uCi

SO uCi 2 uCi 48 uCi

4 mCi 2498.S uCi lSOl.S uCi

3H (uCi) 14C (uCi)

SOLID 41.36 8.03

Liquid 200S.8S 94.40

Sharps 32S.OO 0.2S

Scintillation 18.79 4.82 Vials

TOTAL 2391.00 107.SO

CONFIRM

v v i,/

/

./

v7 /

./

/

/ ~

~KARC2>S t> ~RMAC:lvrJCAL.S


DATE: \8 oa loi3 AUDITOR: PAl 5.JIJ(lp."':,~ ~U/liU._,.--

ISOTOPE MATERIAL

VIAL# AMOUNT

DESCRIPTION REC'D

3H L-Tryptophan 8-11-11 250 uCi

3H 5-3-L -Tryptophan 8-23-11 1 mCi

3H 5-Hydroxy 1-20-12 250 uCi

Trvotamine

3H 5-L-Tryptophan 1-23-12 1 mCi



3H Deoxy-D-Glucose 3-13-13 250 uCi

3H 5-L -Tryptopha n 5-16-13 1 mCi


14C L-Tryptophan 10-5-11 50 uCi

14c A-Methyl-L -1-10-12 50 uCi

trvotophan

14C Hydroxy Tryptamine 9-26-12 50 uCi

14c KC0009 (KAR5205) 8-14-13 1 mCi

TOTALS

STORED WASTE to be Disposed 16Jan2014

3514 uCi

2013 START AMT

5 uCi

445 uCi

249 uCi

255 uCi

405 uCi

1 mCi

250 uCi

1 mCi

1 mCi

50 uCi

44.5 uCi

48 uCi

1 mCi

5751.5 uCi

SOLID

Liquid

Sharps

Scintillation Vials

TOTAL

AMOUNT AMOUNT in in WASTE STORAGE

5 uCi

445 uCi

249 uCi

255 uCi

405 uCi

1 mCi

220 uCi 30 uCi

1 mCi

120 uCi 880 uCi

50 uCi

44.5 uCi

48 uCi

69 uCi 931 uCi

3514 uCi 2237.5 uCi I

3H (uCi) 14C (uCi)

234.0 24.2

2751.2 37.6

418.0 0.0

41.8 7.2

3445.0 69.0

CONFIRM

v v v v

v v ,,/ v'

v v .,../

-v v

!lfl<AR0S ti PMARMAC:•VflCAl..S


DATE: \·~ {)el, 'Wii..\ AUDITOR: ~l\r Fx0 ~ ~.,___,

ISOTOPE MATERIAL VIAL#

AMOUNT DESCRIPTION REC'D

3H L-Tryptophan 8-11-11 250 uCi

3H 5-Hydroxy 1-20-12 250 uCi

Trvotamine

3H Deoxy-D-Glucose 3-13-13 250 uCi


14c L-Tryptophan 10-5-11 50 uCi

14( A-Methyl-L-1-10-12 50 uCi

tryptophan

14C Hydroxy Tryptamine 9-26-12 50 uCi

14( KC0009 (KAR5205) 8-14-13 1 mCi

TOTALS

STORED WASTE to be Disposed 9Jan 2015

155 uCi

2014 START AMT

5 uCi

249 uCi

30 uCi

880 uCi

50 uCi

44.5 uCi

48 uCi

931 uCi

2237.5 uCi

SOLID

Liquid

Sharps

Scintillation Vials

TOTAL


5 uCi

249 uCi

30 uCi

128 uCi 752 uCi

14 uCi 36 uCi

44.5 uCi

11 uCi 37 uCi

2 uCi 929 uCi

155 uCi 2082.5 uCi

3H (uCi) 14C (uCi)

3.8 2.8

122.3 21.5

0.0 0.0

1.9 2.7

128.0 27.0

CONFIRM

\.,...,,..--

v

J / j,,/'/

/ /

;,


DATE: 13 QJG 2c1~s AUDITOR: PM f?Ai"\JR.A-SSf-¥ fttUR..<ll.£W-


AMOUNT DESCRIPTION REC'D

3H

3H

3H

3H

3H

14c

14c

14c

14c

L-Tryptophan 8-11-11 250 uCi

5-Hydroxy 1-20-12 250 uCi

Tryptamine

Deoxy-D-Glucose 3-13-13 250 uCi

5-L -Tryptopha n 10-24-13 1 mCi

5-L-Tryptophan 4-15-15 1 mCi

L-Tryptophan 10-5-11 50 uCi

A-Methyl-L-1-10-12 50 uCi

tryptophan

Hydroxy Tryptamine 9-26-12 50 uCi

KC0009 (KAR5205) 8-14-13 1 mCi

TOTALS

STORED WASTE to be Disposed ~A zo\·r

974 uCi

2015 START AMT

5 uCi

249 uCi

30 uCi

752 uCi

1 mCi

36 uCi

44.5 uCi

37 uCi

929 uCi

3082.5 uCi

SOLID

Liquid

Sharps

Scintillation Vials

TOTAL


5 uCi

249 uCi

30 uCi

752 uCi

217 uCi 783 uCi

36 uCi

44.5 uCi

37 uCi

929 uCi

974 uCi 2108.5 uCi

3H (uCi) 14C (uCi)

964.0 0.0

0.0 0.0

0.0 0.0

9.7 0.0

974.0 0.0

CONFIRM

t/

j,,/

./

./ /'

/ !;"''

,r v /' v

v

"~~~2:~ LABORATORY ISOTOPE RECORD - 2016 Year End INVENTORY

DATE: Ci DeZ.. 20tb AUDITOR: ft~ B(.U)tl-\~ flflvt/Lt1...--


AMOUNT 2016 AMOUNT AMOUNT in CONFIRM DESCRIPTION REC'D START AMT in WASTE STORAGE

3H 5-Hydroxy 1-20-12 250 uCi 249 uCi 249 uCi \/"" Trvotamine

3H Deoxy-D-Glucose 3-13-13 250 uCi 30 uCi 30 uCi v'.

3H 5-L-Tryptophan 4-15-15 1 mCi 783 uCi 2 uCi 781 uCi / t4C L-Tryptophan 10-5-11 50 uCi 36 uCi 36 uCi /

3H Methyl-Thymidine 7-29-16 250 uCi 250 uCi 250 uCi /

t4c A-Methyl-L -1-10-12 50 uCi 44.5 uCi 44.5 uCi v

trvotoohan

t4c Hydroxy Tryptamine 9-26-12 50 uCi 37 uCi 37 uCi ,/

t4c KC0009 (KAR5205) 8-14-13 1 mCi 929 uCi 929 uCi / t4C Oleic Acid 6-22-16 50 uCi 50 uCi 47.5 uCi 2.5 uCi

~·

TOTALS 2408.5 uCi 49.5 uCi 2359 uCi

STORED WASTE 3H (uCi) 14C (uCi)

49.5 uCi SOLID 0.0 2.75

Liquid 2.0 43.05

Sharps 0.0 0.4

Scintillation 0.0 1.3

Vials

TOTAL 2.0 47.5

LABORATORY ISOTOPE RECORD - 2017 Mid-Year INVENTORY

DATE: \ 1- JV~ ZO 1"1-AUDITOR: PM t3~A

ISOTOPE MATERIAL

VIAL# AMOUNT 2017 AMOUNT AMOUNT in

CONFIRM DESCRIPTION REC'D START AMT in WASTE STORAGE

3H 5-Hydroxy 1-20-12 250 uCi 249 uCi 249 uCi v Trvotamine

3H Deoxy-D-GI ucose 3-13-13 250 uCi 30 uCi 30 uCi ./

3H 5-L -Tryptopha n 4-15-15 1 mCi 781 uCi 781 uCi \/"'

3H Methyl-Thymidine 7-29-16 250 uCi 250 uCi 207 uCi 43 uCi v"'"

14c L-Tryptophan 10-5-11 50 uCi 36 uCi 36 uCi /

14c A-Methyl-L-1-10-12 50 uCi 44.5 uCi 44.5 uCi v

tryptophan

14c Hydroxy Tryptamine 9-26-12 50 uCi 37 uCi 37 uCi / 14( KC0009 (KAR5205) 8-14-13 1 mCi 929 uCi 929 uCi v"

14( Oleic Acid 6-22-16 50 uCi 2.5 uCi 2.5 uCi v TOTALS 2359 uCi 207 uCi 2152 uCi

STORED WASTE 3H (uCi) 14C (uCi)

207 uCi SOLID 2.3 0.5

Liquid 170.6 32.3

Sharps 0.0 0.0

Scintillation 1.1 0.2

Vials

TOTAL 174.0 33.0

Waste Disposal Report - 4Jan2013

Date Isotope Chemical Form Solid Liquid Sharps LSC

Added (uCi) (uCi) (uCi) (uCi) 7/29/11 ... c L-Tryptophan 0.07 3.50 0.03 8/1/11 ... c L-Tryptophan 0.14 7.00 0.06 8/2/11 ... c L -Tryptophan 0.14 7.00 0.06 8/3/11 ... c L-Tryptophan 0.06 4.90 0.04 8/4/11 ... c L-Tryptophan 0.15 6.30 0.05

8/5/11 '"'C L-Tryptophan 0.06 4.90 0.04 8/5/11 "H 5-L-Tryptophan 0.25 18.60 1.00 0.15 8/8/11 "H 5-L-Tryptophan 0.53 8.40 1.00 0.07 8/9/11 "H 5-L-Tryptophan 1.20 97.00 1.00 0.80

8/10/11 '"C L-Tryptophan 0.37 15.00 0.13 8/11/11 "H 5-L-Tryptophan 0.60 48.00 1.00 0.40 8/12/11 .lH 5-L-Tryptophan 0.20 23.70 1.00 0.10 8/16/11 "H 5-L-Tryptophan 0.70 43.00 1.00 0.30 8/17/11 jH 5-L-Tryptophan 0.20 23.70 1.00 0.10 8/18/11 "H 5-L-Tryptophan 0.43 18.50 1.00 0.07 8/19/11 "H 5-L-Tryptophan 0.20 23.70 1.00 0.10 8/24/11 '"C L -Tryptophan 0.06 4.90 0.04 8/24/11 "H 5-L-Tryptophan 0.20 25.70 1.00 0.10 8/25/11 "H 5-L-Tryptophan 0.50 55.30 1.00 0.20

9/13/11 '"C L -Tryptophan 0.06 4.40 0.04 9/14/11 '"C L-Tryptophan 0.06 3.90 0.04 9/20/11 jH 5-L -Tryptophan 0.40 48.40 1.00 0.20 9/21/11 "H 5-L-Tryptophan 0.40 48.40 1.00 0.20

9/22/11 '"C L-Tryptophan 0.06 4.90 0.04 9/22/11 "H 5-L-Tryptophan 0.20 28.70 1.00 0.10 9/23/11 "H 5-L-Tryptophan 0.20 13.70 1.00 0.10 9/27/11 '"C L-Tryptophan 0.05 3.65 0.05 9/27/11 "H 5-L-Tryptophan 0.25 18.65 1.00 0.10 10/5/11 '"C L-Tryptophan 0.45 4.50 0.05 10/6/11 '"C L-Tryptophan 0.85 8.10 0.05 10/7/11 "H 5-L -Tryptophan 0.80 53.00 1.00 0.20 10/13/11 '"'C L-Tryptophan 0.45 4.50 0.05 10/19/11 "H 5-L-Tryptophan 0.55 28.30 1.00 0.15 10/25/11 "H 5-L-Tryptophan 0.55 28.30 1.00 0.15 10/27/11 "H 5-L -Tryptophan 0.55 28.30 1.00 0.15 11/16/11 "H 5-L-Tryptophan 0.80 43.00 1.00 0.20 11/17/11 "H 5-L -Tryptophan 1.60 97.00 1.00 0.40 11/21/11 "H 5-L-Tryptophan 0.85 34.00 1.00 0.15 11/29/11 "H 5-L-Tryptophan 0.50 23.40 1.00 0.10

Total "H (p. 1 of 3) 12.66 878.75 24.00 4.59 Total J.'tc (p. 1 of 3) 3.03 87.45 o.oo 0.77


Date Isotope Chemical Form Solid Liquid Sharps LSC Added (uCi) (uCil (uCil (uCil 12/9/11 "H 5-L-Tryptophan 0.75 53.00 1.00 0.25

1/12/12 "H 5-L -Tryptophan 0.75 54.00 10.00 0.25

1/24/12 "H 5-L-Tryptophan 0.20 8.00 1.80

1/24/12 "H 5-HydroxyTryptamine 0.20 0.80

1/25/12 l'lc A-Methyl-L-Tryptophan 0.50 2.50

1/25/12 "H 5-L-Tryptophan 0.75 41.00 8.00 0.25

1/26/12 "H 5-L-Tryptophan 0.75 51.00 8.00 0.25

1/30/12 "H 5-L -Tryptophan 0.70 36.00 8.00 0.30

2/2/12 "H 5-L-Tryptophan 0.70 36.00 8.00 0.30

2/16/12 "H 5-L-Tryptophan 0.70 36.00 8.00 0.30

2/21/12 l'lc A-Methyl-L-Tryptophan 0.75 1.25 0.50

2/22/12 "H 5-L-Tryptophan 0.70 36.00 8.00 0.30

2/28/12 "H 5-L-Tryptophan 0.70 36.00 8.00 0.30

3/7/12 "H 5-L-Tryptophan 0.70 26.00 8.00 0.30

3/29/12 "H 5-L-Tryptophan 0.70 31.00 8.00 0.30

3/30/12 "H 5-L-Tryptophan 0.70 31.00 8.00 0.30

4/12/12 "H 5-L-Tryptophan 0.70 31.00 8.00 0.30

4/13/12 "H 5-L-Tryptophan 0.70 31.00 8.00 0.30

6/18/12 "H 5-L-Tryptophan 0.70 31.00 8.00 0.30

7/26/12 "H 5-L-Tryptophan 0.60 21.10 8.00 0.30

8/2/12 "H 5-L -Tryptophan 1.50 38.00 10.00 0.50

8/3/12 "H 5-L-Tryptophan 1.50 38.00 10.00 0.50

8/6/12 "H 5-L-Tryptophan 0.60 21.10 8.00 0.30

8/8/12 "H 5-L-Tryptophan 0.85 10.00 4.00 0.15

8/8/12 "H 5-L-Tryptophan 0.85 10.00 4.00 0.15

8/9/12 "H 5-L-Tryptophan 0.60 21.10 8.00 0.30

8/13/12 "H 5-L-Tryptophan 1.40 42.00 16.00 0.60

8/14/12 "H 5-L-Tryptophan 0.70 21.00 3.00 0.30

8/15/12 "H 5-L -Tryptophan 0.70 31.00 8.00 0.30

8/16/12 "H 5-L-Tryptophan 0.70 31.00 8.00 0.30

8/22/12 "H 5-L-Tryptophan 0.70 31.00 8.00 0.30

8/23/12 "H 5-L-Tryptophan 0.70 31.00 8.00 0.30

8/28/12 "H 5-L-Tryptophan 0.70 31.00 8.00 0.30

9/5/12 "H 5-L-Tryptophan 0.70 21.00 3.00 0.30

9/6/12 "H 5-L-Tryptophan 0.60 21.10 8.00 0.30

9/10/12 "H 5-L-Tryptophan 0.70 31.00 8.00 0.30

9/13/12 "H 5-L-Tryptophan 0.60 21.10 8.00 0.30

9/16/12 "H 5-L -Tryptophan 0.60 21.10 8.00 0.30

11/7/12 l'lc L-Tryptophan 3.50 4.00 0.25 1.00

Total ~H (p. 2 of 3) 26.40 1052.60 269.00 13.00 Total ..... c (p. 2 of 3) 4.75 S.25 0.25 4.00


Date Isotope Chemical Form Solid Liquid Sharps LSC Added (uCi) (uCi) (uCi) (uCi) 11/8/12 i"C 5-HydroxyTryptamine 0.25 1.70 0.05 11/9/12 "H 5-L-Tryptophan 0.60 21.10 8.00 0.30 11/30/12 "H 5-L-Tryptophan 0.60 21.10 8.00 0.30 12/4/12 "H 5-L-Tryptophan 0.60 21.10 8.00 0.30 12/5/12 "H 5-L-Tryptophan 0.50 11.20 8.00 0.30

Solid Liquid Sharps LSC IUfAL

(uCi) (uCi) (uCi) (uCi) (uCi) Total ~H (p. 3 of 3) 2.30 74.50 32.00 1.20 110.00 Total ;sH (p. 2 of 3) 26.40 1052.60 269.00 13.00 1361.00 Total ;sH (p. 1 of 3) 12.66 878.75 24.00 4.59 920.00

Total ..... C (p. 3 of 3) 0.25 1.70 0.05 2.00 Total .L'tc (p. 2 of 3) 4.75 5.25 0.25 4.00 14.25 Total ..... C (p. 1 of 3) 3.03 87.45 0.00 0.77 91.25

Total Waste - ~H 41.36 2005.85 325.00 18.79 2391.00 Total Waste - 14C 8.03 94.40 0.25 4.82 107.50

Waste for Disposal 2498.50

p.• il i"f t J } '~----- t• _ __J_ t ____'.__ -~ _!I.

~

~FORMSCQ ~SHIPPER- tw.EANO FACILITY SH!PPERIOI ·-,_...,,..,_ PAGE 1 _tJHl!(S) a.: ........ NWlilef Chae~Gtcqi. lne. NIA _,_"" __ OF _1...J>AOe(S) (l.lottlt.-.. ..... -~

UNIFORM LOW4.EVEL RADIOACTIVE 11450 Watterson Court xi..,.,...,..,.. _,_"...., .... -1.J'AG!lS) WASTE MANIFEST Louisville, KY 40299 [PllOCU80fl ....:m:ow.- !S:LPAGE(Sl T0-2013-002

SHIPPING PAPER --~ t:MeMT• -TYl'l-""l 11.~MDt".IClltYMlOREBI Conlllct

t.EMl!llOEllCYTELS'ttOHl!~lllC\U)e-COlll!) T-KY003-l.13 'A rroxco, Inc. Rick low 8()()-424-9300 CONTACT UUl'tlON!• 109 Flint Road TeleplloneNumblr~-CO<le}

OlllWCIA'TlON SebCannata 86()..3()6-0195 Oak Ridge, lN 37830 86M82-5532 CHEMTREC 8. CARRIER NAME ANO ADDRESS EPAIO# - ~-· ...... 0... f-~ ~-/( •r•.w"»CtLIMM_...._., [l. roTM. taMM a SJ Transportation Co. Inc. NJD071629976

6, _ _ r },,_A..,- . ~

[ ] YES ~- 2 PO 6ox169 stlF!'IN<I D.\.11! fl .. 10. Certification x 1 NO lctflHIS- Woodstown, NJ 08098 11412013 r...• .... ~--............ ~ .............. .-....t ......... ..., ................ ., ......... -....

Ol.w ... -.0-..&i.!\O [ ]YES ~ ... tWa<EST~ CONTACT TelEPHONEI t-: ...................... .._..._'111111 ............... _..._~ ............................. --·- [X) NO Kevin Elder 856-769-2741 i-__ ........................... _... ............ .,.,,. ............ ~ ............ i---- ~\:~.a ( ..... :. . ~\~\\~ ~ SIGNATURE. TTTLE

~~~ ::~:J: {. ~• L ~- "f- .\ U.U.&DEl'AR1lll:HfOF11Wlll'OllTAllCHDUOllP~ t2 ~ 'I 14

. 11\J ' l• tr

.. ,.,__ 'If.ID

~ .... ~---!Ml)-. DOTl.AllB. ,_ PIN80CALAND NlMOUol.!.. TOTAL PA.a<AGE LIWSCO .._.. HIJMR!llCI' ..., _____

~ .. ltlJE:( Q911C,1,1.Al!Qof ~ ACTMTYIN...., ClASS m' PACIQ.CI;

Non DOT Regulated Material NIA NIA SolldfO)Cfde C-14; H·3 1.38E+o1 NIA 0.212 TO-CT-E-13-002

One drum with DAW and shams for d~al &:i. "">-... .... Non DOT Regulated Material NIA NIA Uquld/Oxlde C-14; H-3 7.42E+01 NIA 0.212 TO-LS-E-13-003

One drum with non-hazardous Jiaukls for <ficn-al , , .:l .. ~..,!.. ..

.

Generator Certificallon Stalement: The constituents of the waste manifested herein are known to the generator. Tl\et'e are no EPA RCRA. pathogenic or other hazards present other than those specifically llsted on the Form 541 •

.PA1\Z1aA fJOJ~~ ~A£i£= 1 .. 'i-l3 Print name Sianature Date

CONSIGNEE ORJGINM.. . (MUSr N:;C(M>Nl'f WASTE '1'-liAANSIT)

kf.X""vS

p.=

NRCFORM540

UNIFORM LOW-LEVEL RADIOACTIVE WASTE MANIFEST

SHIPPING PAPER

1. EMERGENCYTELEPHONE NUMBE ONCLUDEAREA CODE)

800-424-9300 ORGANIZATION

CHEMTREC l:i.1S11-llSAN"EXa.USNEIJSE'SHIPMetr7 3. TOTAL NUMBER OF

[ ] YES PACKAGES IDENTIFIED 2 [X 1 NO ON THIS MANIFEsr

f4. OOES EPA REOlL\TED [ ]YES EPA MANIFE5r NUMBER

IWASIE~AMANIFEST [X] NO ~r.a>ANY THIS SHIPMENM'

11. U.S. DEPARTMENT OF TRANSPORTATION DESCRIPTION

Clnclud'111g proper shipping name, hazard class, UN ID number.

and any additiol'tlll infonnafion)

Non DOT Regulated Material

One drum with DAW and sharps for disposal Non DOT Regulated Material

One drum with non-hazardous liquids for disposal

. jl+ARf'S-1 COHBnvID SCL-i.D .

12

DOT LABEL

"RADIOACTIV£"

N/A

NIA

I I! ,. . ·1:··

5. SHIPPER- NAME AND FACILllY

Chase Environmental Group, Inc.

11450 Watterson Court Louisville,KY 40299 USER PERMIT NUMBER 'SHIPMENT#

T-KY003-L 13 N/A CONTACT

Seb Cannata 6. CARRIER NAME AND ADDRESS

SJ Transportation Co. Inc. PO Box15g Woodstown, NJ 08098 CONTACT

Kevin Elder

~NATURE \\(,',..i..tl C"·"a:_ •.

'lh " 14

TRANSPORT PHYSICAL ANO

INDEX CHEMICAL FORM

NIA Solid/Oxide

N/A Liquid/Oxide

SHIPPER ID# 7.NRC FORM540AND540A PAGE 1 _1_PAGE{S) 8. Manifest Number

N/A NRC FORM541 ANDS41A OF _1_PAGE(S) (Use1hls number on an continuation pages)

x lcoLLECTOR NRC FORMS42ANDS42A _1_PAGE(S)

I PROCESSOR ADOmoNALINFORMATION None PAGE(S) T0-2013-002

GENERATOR TYPE [SPECIFV) 9, CONSIGNEE-NAME ANO FACILf!Y ADDREss Contact

TOXCO, Inc. Rick Low TELEPHONE l' 109 Flint Road Telephone Number (Include area code)

860-306-0195 Oak Ridge, TN 37830 865-482-5532 EPAID# SIGNATURE-Authorized consignee acknowledging waste reciept Date

NJD071629976 SHIPPING DATE 10. Certification

1/4/2013 Tllllllll1D~lbllllbo~ll!lllllldl!ldmtnkmaprcpadytlallllllod.daacdbad,~rn:irimd,l9ld.lobolodDhd•.,PfDPGl'lllllldillo:lfot~~

TEu=l'HONE# totllellflPlcllblDl'IC~tlUlll~d'TIBflllllOllD!lgihlllal.otullla91l'dU!IJl!ll1lmldllllfOdauilcrd,~.l!IO!ki:dllfldli:lbD!edfllXlaltl'ln

856-769-2741 ?lgpvfc:icncKh:sirartr:mapc1111ibnlll!d~•~ln.DCICOldonc....uhlha~d10CFRpW20111!!11!il,ar~.mro!QgUlolh:N.

DA"\~\ A~\:~~D SIGNATURE TITLE DI~ \ \'.?> "l\· 1'. ( ...... ~- .• "\~\i\\t.~nl ,,~ t;, 15 \I 16 17 18. lOTAL WEIGHT • 19.10

INOMOUAL TOTAL PACKAGE LSA/SCO OR VOLUME NUMBER OF

AAOIONUCUOES ACTIVllY IN MBq CLASS m3 PACKAGE

C-14; H-3 1.38E+01 N/A 0.212 TO-CT-E-13-002

C-14; H-3 7.42E+01 N/A 0.212 TO-LS-E-13-003

Generator Certification Statement: The constituents of the waste manifested herein are known to the generator. There are no EPA RCRA, pathogenic or other hazards present other than those specifically listed on the Form 541.

PAlR\CiA 5ouRASSI\ iaf~tGl.v--- l-l.f-l3 Print name Signature Date

CONSIGNEE ORIGINAL (MUST ACCOMPANY WASTE 1,N TRANSIT)

'I•

NKl..i t-UKIVI 541 US NUCLEAR REGULATORY COMMISSION 1.1v~"411i;;;;.vl IUIJ\LS 12. iv.,.,.-are<>I NUMBER NUMBER OF NET WASTE N!;TWASTE SPECIAL NUCLEAR MATERIAL (grams)

UNIFORM LOW-LEVEL RADIOACTIVE PACKAGES VOL"'3 WGHTkg U-233 I U-235 Pu TOTAL T0-2013-002 WASTE MANIFEST 2 0.424 ~(") I 3

CONTAINER ANO WASTE DESCRIPTION PAGE 1 OF_1 PAGE(S) ACTIVITY (MBq/mCi) SOURCE 4. SHIPPER NAME

ALLNUCUDES TRITIUM C-14 Tc-99 1-129 (kg) Chase Env. Group 8.79E+01 MBa 8.40E+01 3.89E+OO N/P NIP N/P SHIPPER ID NUMBER 2.38E+OO mCi 2.27E+OO 1.05E-01 NIA

DISPOSAL COITTAINER DESCRIPTION WASTE DESCRIPTION FOR EACH WASTE TYPE IN CONTAINER 16.WASTE

5. CONTAINER 6 7 8 9.SURFACE 10.SURFACE PHYSICAL DESCRIPTION 14. CHEMICAL DESCRIPTION 15. RADIOLOGICAL. DESCRIPTION Cl.ASS

IDENTIFICATION CONTAINER WASTE ANO RADIATION CONTAMINATION 11.WASTE 12.Appraxlnmle 1aSORBENT \VEJGHT INOtvlDUALRAIONUCUDESANOACTMTY (MBq) ANO As-A.STABLE

NUMBER/ DESCRIPTION vot.UME COITTAlNER LEVEL MBql10Dcm2 DESCRIPTOR w..,......,_, SOLIDIFICATION CHEMICAL FORM/ ¥.CHElATING CONTAINER TOTAL: OR CONTAl!':ER TOTALACTMTY AIJ.AUNSTABLE

GENERATOR (SeoNole1) (m3) \VEJGHT _x_uSvlhr BETA- INO'.lN'TAINER STABtLIZATION CHELATING AGENT AGENT ANO RADIONUCLIDE PERCENT B-C1ASSB

NUMBER (kg) mSVJhr ALPHA GAMMA (SeeNole2) (m3) MEDIA(Seo~3) IF7"0.1'ii Nuclide MBq mCi e<:LASSC

TO-CT-E-13-002 4 0.212 <5.00 <3.67E-6 <3.67E-5 39 0.212 100 Oxide/NP NP C-14 218E-01 5.SSE-03 NIA 1183 bl-9 H-3 1.35E+01 3.66E-01

Package total 1.38E+01 3.72E-01 TO-LS-E-13-003 3 0.212 <5.00 <3.67E-6 <3.67E-5 59 0.212 100 Oxide/NP NP C-14 3.67E+OO 9.92E-02 NIA

1183 s- I non-RCRA H-3 7.05E+01 1.91E+OO liquids for disposal Package total 7.42E+01 2.00E+OO

NOTE 1: ContalnerOescriplion Codes. For containers/ IN«e 2; Wal& Cfl!Clipllr Codes. {Chooae up to Uno v.fllch predOm!Mte llyvoll.ane.) ~ole 3: Forsolldlncatlan medln !hat mtlBI dlllpcml :itte strudUral ltlbllll'J requirements, the num!llal code mu.t. bit falowed by •.s. • """""""""_In ___ 20.Ch-1 29. Demolltlon Rubble 35.EwporwtorBoltomtlSludgHI Fanti scDdllk:alfan l'nl!ldla, thev911dar (manuCactun!r)and brand name must.also bo ldentllled In Item 13. Code 100 •NONE REQUIRED.

lthe numerical code must be fonowed by "OP". 121 ................ 30.callaa1onExch4nQftMed.I co-.. 1.WDOdenB<lllotCr.!le 9.Demlnenallmr 22.Soll 31. Anllln Jon Exc1mrae Media 39,Compic:tibleTni:sh Sorption .......... ~- ... 10.QnC)11nder "'""' 32. Mbled Bed 1Dn Exchange Modlll '40.NoneompacUbloTl'llSh 60.SpeediOri ·~..- 73.0lc:lperfHPSOO 89.0ther. Oescrlbe 00.Cema>t 100. Ni;ne

3.PhlSUCOrtlmDl'PaD 11.Bulk,U~Wute. 12-<0I 33.c.cntamhat&C!Eqlfpment 41. AnkMI c.cass 61. Celetom 67.Aorcox 74.Pcdrtllat lnllem13,or 91.Conol>le-) ......... 4.MlllialDJ\ll!Dl'Plil 12.U~Components 125._u.,.. 34.~ilqu1dl.,_.Om <12.BJoog1co1.....,.11"'"""_,,"" 62. RoorDry/ 69.Sdld-A.Sorb 75. Pebosllf.11 -..... 92.!llumon

ls.Mata!TankorUnet 13.HlgttlntegrltyCon!alner 7!l, _,,_. 35.GlossWantarl..abware ca"""' superfine llll.Cherns030 76.- 93.Vlny!Chlorlde

6.ConcretaTankaLlnar 19.0ther.dll8C'!be!Tlltem6, "'·-- ......... """"'°""' 43.ActlvatedMBletlBI 63.HJOri 70. Chemsl SD 77.AqumntR 94.~Es'lerStyJ!lna

.Polyelhyl6neTanlcarUher orldd1tlona1page 28.EPAarStnto 3T.PalntarPlellng 59.0lhrir. Dc!st:fbelnUem11,or 64. Safe-T..Sorb 71.Chemlll3C30 99. other, Describe In Item 13,

8.FlberglmsYonkorUner -- Addlllona!Plge 65.Sale-N·Ori 72 Clcnptll'IHP2DO orAddlllcnDIPllge

NRCFORM542 U.S. NUCLEAR REGULATORY COMMISSION 1. WASTE COLLECTOR/PROCESSOR 2. MANIFEST NUMBER

(5-1998) NAME SHIPPER USE ONLY

UNIFORM NARM RADIOACTIVE Chase Environmental Group, Inc. WASTE MANIFEST IDENTIFICATION NUMBER T0-2013-002

T-KY003-L 13 I 3.

MANIFEST INDEX AND REGIONAL COMPACT TABULATION SHIPPING DATE PAGE_1_0F _1_?AGE(S)

List all original "PROCESSED WAS"re' before "COLLECTED WASTE". 1/4/2013 4. s. 6. 7. 8. 9. 10. 11. AS PROCESSEOICOLl.ECl'ED TOTAL

GENERATOR GENERATOR NAME GENERATOR PREPROCESSED ""'FESTNUMeal WASTE ~1c;q.u,TI>G

IOENTIACATION PERMIT NUMBER FACIUlY WASTE UNDER Wk'ICH WASTE CODE C:OMPAC\' A.SOURCE B.SNM C.ACTMTY D.VOLUME

NUMBER AND TELEPHONE NUMBER ADDRESS (OR MATER~ ,,. .... ,.,.., - "' MATERIAL

VOWME RECS\IEDANDOATE - STATE (MBq) (m3)

("'3) OFREC&l>'T (kg} (g)

1183 Karos Pharmaceuticals 401 Winchester Avenue 0.424 N/A c CT N/P NIP 8.79E+01 0.424 New Haven, CT 06511

203-535-0540

TOTALS OF ALL PAGES (NRC FORMS 542 AND 542A) 0.000 0.000 8.79E+01 0.424

NRC FORM SQ (S-'IUllSJ


Date Isotope Chemical Form Solid Liquid Sharps LSC

Added Cuen Cuen Cuen Cuen 1/7/13 JH Tryptophan 1.2 28.3 10.0 0.5 1/9/13 JH Tryptophan 1.2 28.3 10.0 0.5

1/10/13 JH Tryptophan 5.2 29.3 15.0 0.5 1/16/13 JH Tryptophan 5.2 29.3 15.0 0.5 1/17/13 JH Tryptophan 5.2 29.3 15.0 0.5 1/24/13 JH Tryptophan 5.2 29.3 15.0 0.5 1/25/13 JH Tryptophan 5.2 29.3 15.0 0.5 1/29/13 JH Tryptophan 7.4 51.9 20.0 0.7 1/31/13 JH Tryptophan 7.4 42.0 20.0 0.6 2/19/13 3H Tryptophan 6.5 38.0 15.0 0.5 2/20/13 JH Tryptophan 7.4 47.0 20.0 0.6 2/20/13 3H Tryptophan 1.2 28.3 10.0 0.5 2/21/13 JH Tryptophan 1.2 28.3 10.0 0.5 2/22/13 3H Tryptophan 1.2 28.3 10.0 0.5 2/26/13 JH Tryptophan 0.6 21.1 8.0 0.3 3/1/13 JH Tryptophan 1.2 28.3 10.0 0.5 3/6/13 3H Tryptophan 5.2 29.3 15.0 0.5

3/14/13 JH Tryptophan 0.5 16.2 8.0 0.3 3/19/13 3H Deoxy Glucose 10.0 80.0 10.0 3/21/13 "H Tryptophan 0.6 21.1 8.0 0.3 3/22/13 3H Deoxy Glucose 16.0 2.0 1.8 0.2 3/25/13 "H Tryptophan 0.5 16.2 8.0 0.3 3/26/13 "H Tryptophan 0.6 21.1 8.0 0.3 4/12/13 3H Deoxy Glucose 80.0 12.0 5.0 3.0 4/19/13 "H Tryptophan 0.6 21.1 8.0 0.3 4/24/13 "H Tryptophan 0.6 21.1 8.0 0.3 5/1/13 "'H Tryptophan 1.2 28.3 10.0 0.5 5/2/13 .:iH Tryptophan 1.7 26.0 8.0 0.3 5/7/13 "'H Tryptophan 1.2 28.3 10.0 0.5 5/8/13 "'H Tryptophan 5.2 29.3 15.0 0.5 5/9/13 ,,H Tryptophan 5.2 29.3 15.0 0.5

5/13/13 ,,H Tryptophan 1.2 28.3 10.0 0.5 5/15/13 ,,H Tryptophan 0.6 21.1 8.0 0.3 5/16/13 ,,H Tryptophan 0.6 21.1 8.0 0.3 5/17/13 .:iH Tryptophan 0.6 21.1 8.0 0.3 5/21/13 "'H Tryptophan 8.8 16.2 8.2 0.8 5/22/13 .:iH Tryptophan 0.6 21.1 8.0 0.3

Total "H (p. 1 of 3) 204.00 1026.50 396.00 28.50 Total l. .. c (p. 1 of 3) o.oo o.oo o.oo o.oo


Date Isotope Chemical Form Solid Liquid Sharps LSC Added (uCil (uCil (uCi) (uCi) 8/20/13 l"c 1"[C] KAR5202 24.0 30.0 6.0

8/26/13 l"c 1"[C] KAR5202 1.0

9/25/13 14C 14[C] KAR5202 0.2 7.6 0.2

5/23/13 "H Tryptophan 0.6 21.1 8.0 0.3

5/28/13 "H Tryptophan 0.6 13.2 6.0 0.2

5/29/13 "H Tryptophan 0.6 21.1 8.0 0.3

6/5/13 "H Tryptophan 0.6 29.1 0.3

6/6/13 "H Tryptophan 0.6 29.1 0.3

6/12/13 .:SH Tryptophan 5.2 44.2 0.6

6/18/13 "H Tryptophan 1.2 38.2 0.6

6/20/13 "H Tryptophan 1.2 38.2 0.6

6/26/13 "H Tryptophan 1.2 38.2 0.6

7/2/13 "H Tryptophan 0.6 29.1 0.3

7/10/13 "H Tryptophan 1.2 38.2 0.6

7/11/13 "H Tryptophan 0.6 29.1 0.3

7/12/13 "H Tryptophan 1.2 38.2 0.6

7/17/13 "H Tryptophan 0.1 9.8 0.1

8/8/13 "H Tryptophan 0.6 29.1 0.3

8/14/13 "H Tryptophan 0.6 29.1 0.3

8/26/13 "H Tryptophan 1.2 38.2 0.6

9/6/13 "H Tryptophan 0.6 29.1 0.3

9/12/13 .:SH Tryptophan 0.7 33.9 0.4

9/13/13 3H Tryptophan 0.7 33.9 0.4 9/24/13 "H Tryptophan 0.7 33.9 0.4

9/25/13 .:SH Tryptophan 0.7 33.9 0.4

9/27/13 "H Tryptophan 0.6 19.1 0.3

10/21/13 .:SH Tryptophan 0.6 29.1 0.3

10/22/13 3H Tryptophan 0.6 29.1 0.3 10/22/13 3H Tryptophan 215.0

10/23/13 3H Tryptophan 445.0

10/23/13 3H Tryptophan 0.6 29.1 0.3 10/24/13 "H Tryptophan 0.6 29.1 0.3 10/28/13 "H Tryptophan 0.6 29.1 0.3

11/7/13 "H Tryptophan 0.6 29.1 0.3 11/12/13 "H Tryptophan 0.6 29.1 0.3

11/13/13 "H Tryptophan 0.6 29.1 0.3

Total ;,H (p. 2 of 3) 26.70 1589.80 22.00 11.50 Total l.'lc (p. 2 of 3) 24.20 37.60 o.oo 7.20


~ ISOtoRI {;b1migl FQrm ~ Ligyid :ih1m1 LSC Added (uCil cucn (uCil (uCil

11/14/13 "H Tryptophan 0.6 24.1 0.3 11/15/13 "H Tryptophan 0.6 24.1 0.3 11/18/13 .:iH Tryptophan 0.6 19.1 0.3

11/21/13 .:iH Tryptophan 0.6 19.1 0.3

11/22/13 .:iH Tryptophan 0.9 48.5 0.6

Solid Liquid Sharps LSC IUfAL

(uCil (uCi) (uCil (uCi) (uCi) Total 3 H (p. 3 of 3) 3.30 134.90 0.00 1.80 140.00 Total ~H (p. 2 of 3) 26.70 1589.80 22.00 11.50 1650.00 Total ~H (p. 1 of 3) 204.00 1026.50 396.00 28.50 1655.00

Total .L'lc (p. 3 of 3) 0.00 0.00 0.00 0.00 0.00 Total .... c (p. 2 of 3) 24.20 37.60 0.00 7.20 69.00 Total .... c (p. 1of3) 0.00 0.00 0.00 0.00 0.00

Total Waste - 3 H 234.00 2751.20 418.00 41.80 3445.00 Total Waste - J.4c 24.20 37.60 0.00 7.20 69.00


NR:c F<)j;M 540 lt SJIJ'PE!t· NAM! Nm fACIUlY SHl'PJl&JUD I ~.---- PAGE 1 _1.J>J.Clltll 8.~lolnblr

' tchalll ~tlllll GRKip. m. NfA __ .. ,_ .....

OF _1_PMlll!(&) IUMINl-•ld .......... llOJlll)

UNIFORM LOW·UM:L.RADIOACTIVE 114!0 Wdel'$Ol'I COUrt x fCQ.U;O;TCll JfSllilat4#.'Kl.._ ~ W"8Tr:MANll'l!ST l.oul&vllle, KY 40299 I~ -- !la..IAGl!Ct> T0-2014'-016

stlll'PIMO PAPl!R --itulil&R ISffiM'llfl'• -.,,.~ .. ---Al<QFM;llJIY~ ~

l.DQ--ll,Ulll~l#ACOOI) T-KV-O~L14 NIA TOXCO,lnc. Rld<Low 800-424-9300 CONl'ACT 'l!Ul'HON!l I 109 Finl Road tr•~ tbaber(1t.Qlde11Ca cxxle)

OllCIAXIZATIClll Seb Cennata aeo.3CJll.01B5 Oak Rkfmi, TN 37830 865-482..0S32 Chembec WSDS#: CHEN01RAD 8. CARRIER HANE.ANO J\DDRE69 EPAID;t ·-111'11-IOdlcll DMe ............ ....., 11. 'l'O°t'l.llWSl'ROP SJ TllinsPortat!On Co., Inc. NJ0071629976 ~.z~ 3-'3 ... J((

I J YES ~IDl!lllPllD 2 POBox189 SllPl'<NCI IMTI! , 10. c.rtilication

(X] NO Qllltall.-nt' Woodstown, NJ 08098 1H6'/2014 __ ..,..._._...,.__,...., ... ~ ............................................................. -- ( ) TCS !PAINftlTMMlll CONTACT T!l.IJlllOll2.• ........... ...-...n. ............................................................ ................ (lC) NO Kevin Elder 888-7t9-27.41 ~ .. -..........._..__.... .......... " ........ ,,, ............ ,,~......_ -- NA llll't':t ~ DA"J'E I L711P i't ):~8~~R£ nn.e

~hbltrf' ·t:UL 11.UPIPNINDITOl',_'IJCINllUClll"llCIN I! ti f4 II 11 11 tL 'IDDILIRJltfl' 11.PJ r-.,_._.. ___ Ut111-

nori.-. - -""° -~ TOT>L. PACKAGE UNICO ......... _.., ........... --l -- - c!IW~f'OIW ~ ACrMfV IN MSq Cl.ABS ma -Non DOT Regulated Maria! NA NA Solid/Oxide C-14;H~ 2.47Et01 NA 0.212 TO.CT-E-14-027 ,,_.., -One dnlm W11h DAW aoo SHARPS for dlaoosal Non DOT Regulated Material NA NA LlqU!d/UlOO& CM4; H-3 1.05E+02 NA 0.212 TO-lP-&1+-028

_ .. :. ---One drum with Uauld and Wlls for dl$D01111I

Generator certt11Calion Statement: The constituents of the waste manlfesled herern are known to the generator. There are no EPA RCRA. palhogenlc or other hazards present other than those specfflcally listed on the Form 541.

-PAlR.iOA ~KASSA- ~fuuo&;:--- , ... ib·l'f Print name S1onature Dale

CONSIGHEE ORICltw. (MUIT ACOOMPANYWASTl!lHTRNISITT

kArtt:S.

NRCFORM540 5. SHIPPER· NAME AND FACILITY SHIPPER ID# 7. NRCFORM540AND 54DA PAGE 1 _1_PAGE(S) 8. Manifest Number Chase Environmental Group, Inc. N/A MRC FORM SC.1 AAOS41A OF _1_PAGE(S) (Uso1his number on all continuation pa(les)

UNIFORM LOW-LEVEL RADIOACTIVE 11450 Watterson Court X (COLLECTOR NRCFORM~l-N0542A _1_PAGE(S)

WASTE MANIFEST Louisville, KY 40299 IPROCSSSOR ADDmCNAt. l~FORJM'OON None PAGE(S) T0-2014--016 SHIPPING PAPER USER PSl<MIT NuMBER 1•HIPMcNT# GENEAATOR1YPE.{SPEC1FY] 9. CONSIGN&-NAME ANO FACILITY ADORESS Contact

1. EMERGENCY TGlS'HONE NUMBE (INCLUDE AflEA CODE) T-KY003-L14 NIA TOXCO, Inc. Rick Low 800-424-9300 CONTACT TB.E?HONE# 109 Flint Road Telephone Number (Include area code)

ORGANIZATION Seb Cannata 860-306-0195 Oak Ridge, TN 37830 865-482-5532 Chemtrec WSDS #: CHEN01RAD 6. CARRIER NAME AND ADDRESS EPAlD# SIGNAlURE-Authorlz~d conslgnte aelr.nov.4edglng waste reclept Date

~JS1H15Nf'10XCl..l.tSllJEUBE"$HJPMEJrm 3. TOTAL NUMBER OF SJ Transportation Co., Inc. NJD071629976 I l YES PACKAGES IDENTIFIED 2 PO Box 169 SHIPPING OATS: 1 O. Certification IxJ NO ON THIS MANIFEST Woodstown, NJ 08098 1/16/2014 1""11.•~Nt1!llllanJl11Nn..d.-.Ol•-~~.o-illlod,poda!G•d, ...... dW!oiododaNll!llDPll'~for~I~

4.gga EPAAEOUtAtm [ ]YES EPA MANIFEST NUMSER CONTACT TELEPHONE# IO~~rag&1'8Dm'l1aC'lhOOiip1W11111tPll~'Thl1•eara...11111C0tt~wacradad.---=-niorltGdGlllllabioll4md.-td

Wl'ISTE1UiOURlll1A MANfESt [xj NO Kevin Elder 856-769-27 41 ~gi11"m1111tcn111r......-rtncin1icrc1111p....ir.s~ •• -=~..ta.1111>'""'l'll!ltllOllaollO~p111m»ollde.l,or""""-'-"'ai.~

~- NA SlG\ll.Jl<E. DATC • )~~,S~GNATURE mLE DATE ,. ~LtJ.i.. b....,_......_ lr11v/H ·~.~ i/{1:/ {f

11. U.S. OOPARTMENTOFTRANSPCRTATION DESCRIPTION 12 13 14 15 16 17 16. lOTAl..VV?IGHT 19. ID

O~ll.ldlna pro~ers~klg name, hazard class, UN ID11umber. DOT I.ASEL TRANSPORT PHYSICAL ANO INOMOUAL TOTAL PACKAGE LSA/SCO ORVOUIME NUMBER OP:

and any addltioncll Information) "IW>IOACT1\IE" INDEX CHEMICAL FORM RADIONUCUCES ACTIVITY IN MBq Cl.ASS m• PACKAGS

Non DOT Regulated Material NA NA Solid/Oxide C-14; H-3 2.47E+01 NA 0.212 TO-CT-E-14-027

One drum with DAW and SHARPS for disposal Non DOT Regulated Material NA NA Liquid/Oxide C-14;H-3 1.05E+02 NA 0.212 TO-LP-E-14-028

One drum with llQuid and vials for disposal


-t>A\R.IGA BcvRA~.\- -f2tJz11~/~/V I- ib-i L.f-Print name Signature Date

CONSIGNEE ORIGlNAL {MUST ACCOMPANY WASTE IN TRANsrn

..

!""'' <"VNVO 041 US NUCLEAR REGULATORY COMMISSION ..... ~, -~~• IUfAL~ 12. IVlf'\l"ri::<> 1 NUMl:lt:K

NWBEA.CF t.IETWASTE NETWAS'l'S SPECIAL NUCLEAR MATERIAL (orams) UNIFORM LOW-LEVEL RADIOACTIVE PACKAGES VOl.m:l WGl<l">g U-233 U-235 Pu TOTAL T0-2014-016

WASTE MANIFEST 2 0.424 ~S~5

NP NP NP NP 3.

CONTAINER AND WASTE DE:SCRIPTION PAGE 1 OF_1 PAGE(S) ACTIVITY (MBqlmCi) SOURCE 4. SHIPPER NAME

ALLNUCLIDES TRITIUM C-14 Tc-99 1-129 (kg) Chase Environmental Group 1.30E+02 MBQ 1.27E+02 2.55E+OO NP NP O.OOE+OO SHIPPER ID NUMBER 3.51 E+OO mCi 3.44E+OO 6.90E-02 NIA

DISPOSAL CONTAINER DESCRIPTION WASTE DESCRIPTION FOR EACH WASTE 1YPE IN CONTAINER 16.WNJTE

5.CONTAINER 6 1 8 9..SIJRFACE. 1a.SUP.F~ PHYSICAL DESCRIPTION 14. CHEMICAl. DESCRIPTION 15. AAOIOLOG!CALDE:SCRIPTION Cl.ASS

IOSNTIFICATION cor;r"""" WASTI;AAO AACJATION COl'rr,tW;tNATIOfl 11.WhS'TE 12.~l'Olllm· 13.SOUl!KT We!GHT INOIVIDl.IAl.IWONUCUDESJ\tlOACTMTY(MBq)>.ND AS-AS1ABLE

NUMBER/ llESCRJl>'l\ON VOLUMt:. CONT A!~ LEVEL MB<t100cm2 DESCRIFl'OR w""''°""""' GOUDIFICJl.TION CHEMICALl'ORtM · '!r.CKEtATINQ CONT.AlHt:R TQT,\1.:0R CCNTAIMeR TCTA1..ICTMTY AU-A UNSTASlE

GENERATOR {SaAoH~lo'J) (m3) WEl<iliT _x_usv/hr ae.TA- ~-- STA!fl.IZATJON CHEl.AllNGAGENT AG!NT AND RADIOWQ.lQE PERCENT B-OIJISS•

NUMBER (kg) mSvihr ALPliA GPM"' {ScaN<*J2J (m3) MEOIA1$411)Noto3) IF>0.1% Nuc;:lide MBo mCi oc .... c

TO-CT-E-14-027 4 0.212 <5.0 <3.67E-6 <3.67E-5 39 0.212 100 Oxide/NP NP C-14 B.95E-01 2.42E-02 NA 1183

bFl'~< H-3 2.38E+01 6.44E·01

I Package total 2.47E+01 6.GSE-01

TO-LP-E-14-028 3 0.212 fflo <5.0 <3.67E-6 <3.67E-5 25,35 0.212 100 Oxide/NP NP C-14 1.66E+OO 4.48E-02 NA 1183 H-3 1.03E+02 2.79E+OO

., i Package total 1.05E+02 2.84E+OO

' 1

I I

I I

NOTE 1~ Contlllner Desc:rlptlo.n COdes.. For contalna/ NQW:Z:W11ft Drlclc:dpiorCctr.i.. tcflODG1MpJOthno~proclonilrt1to?iy'lol.lfnlll.) JW1.i;i3;ForllOlldlllco!Jonmo0111thiltmootdbpoulllW1rtn1ctu~l~fQqlllrvm0111S1 1t1011~~111mimt10foltciwod by".$."

VQlrtaraqulrlnod1apouJ!n111p~~av..,oc11:1, '°'°"'- 21.DllmalllklnRutibla ~. E.wpomir BcbOlrlllfSllldgcal or.;Q oMlcllllcat!Ofl modb..tho'lllltlllnr~~l')ond.bl2!1d 1111111omdo1Gcibolc:llllllllll•'lllllcm13. Codlll100•NONEREQUIR?O.

the nurnencal cocle ITIU:rt befotleNmd bf •op•, 21.tncln..mcr.Mh aa.COSlarlfoll;~l.Udlo. """'-1,Woolfon ~crcmio $1.0a.nlnll'llb:ir 22.Solll 31.ArllOlllonEx~ Modla ~.COrnpa~oT11ah Sorpijon

! Sfld!Deltioq

2.Mota!S. 10.GmoC>Jl!nckar 2'.Cll!I. a2. Mbmd89CI lan~1Mtdb .cc.Noncom~Tni1h 50.Spoe<!IOrl ........ )3-Qk:lporlHPSOO $9,0IMt. CllOCl'h ...-... 100. ~onQ

3.MdlGDn.rnorP~ 11.aJt.l,r.p~ w .... "'-"' =. ConQn.IJloO~ Eqvlpmonl -'1.AnlmDI~ 61.Coletom 67 ....... ~ 7~- lr\llaft\13.cr !11.CQ'l~~l -4.MOIBIONmorPllll. 1:.tJripcD:igodeoJ OM .. 2:S..Aicll.clldUquld 34.0rgi111fc:llqu!IS(E»:cpt.Oll) 42.Blol~Uotulil!{£llcopLAQ!mAICll 52. E!loororyt ~SiiacM-Sozt 7S.Patnm1U ~ddll;l1lrGllpD~ 82..mtumcn

5.M<ltDCTMlkorUNr 13.W;tllr4tg1'4:tCcr i- a. morMad11 :is.~or~ - Superftne 69.(;hGmall:SO 7G. ,t.qlmlM~ Q3.Vlpy!Ch1Drld1

1. Corovit. Tu.Ir.« Llnor 19.0lhtr.~lc1 i-~ 27. Modlarlleo!RW 3'.SlllMd:~bo 41 M1\va*ad Maitl~ 51 HID!! Til.CMmall :50 71.M~ll 114..Vln,IEM'~• I !

T.PDlyoth'11on11Tlnkorl.hsr or~nnt1 21.~PAorsi. ~7.Pal'ntarPlatiM 59.Qtlfr,~ball!lloml1,or 84. Safe.T.SOrO fl.Cllaml~3030 11'9.0llUU'.Do!SedbGlnlllom13,

H.-~ 65. Saf&oN-Orl !

8.Fba'$11GO&TllllcwlJtJar ~lc~o!P1ga. 12.0kaP«IHP200 orAddllfdP:lge

! I

' I

!

'

I

NRCFORM542

,{5-1996)

U.S. NUCLEAR REGULATORY COMMISSION 1. WASTECOLLECTOR/PROCESSOR 2. MANIFESTNUMBER

NAME UNIFORM LO~ ·LEVEL RADIOACTIVE Chase Environmental Group, inc.

WAS "E MANIFEST lDENTIFlCAT!ON NUMBER

I T-KY003-L14 • MAN1FesTtNDEXAND itEG10NALCOMPACTTABuLA110N isHIPPINGDATE

' List all original '?ROCESSE~ WASTE' before "COLLECTED WASTE". 1/16/2014 14.

GENERATOR

IDENTIFICATION

NUMBER

1183

's. i. 1•· SRATOR NAME GENERATOR

Pl RMIT NUMBER FACIUlY

AND LEPHONE NUMBER ADDRESS

I i<aros-Pha,~ceuticals

203-535-054,~

401 Winchester Ave. New Haven, CT 06511

17.

AAEPROCESSS>

WAS'll'

(ORMATE.RlAl.)

VOL.LIME

("'3)

0.424

8.

..... ...,.,...... ~e4'RWHICtiWASTE

tOR~

flECevt:DANC~

,,._,

NA

TOTALS OF All PAGES (NRC FORMS 542 AND 542A)

NRCA:;RM542(d-.UKl

9.

WASTE

CODE

~-.. ,.. .... c

110.

""""""".

"" STATI'

er

SHIPPER USE ONLY

T0-2014-016

3.

PAGEU_OF _1_PAGE(S)

11. ASPROCt:SSED/COU.ECTEOToTAL

A, SOURCE

MATERIAL

(kg)

O.OOE+OO

0.000

B.SNM

(g)

NP

0.000

C. ACTlVITT' l),VOLUMt:

(MBq) (m3)

1.30E+02 OA24

1.30E+02 0.424

..


Date Isotope Chemical Form Solid (uCi) Liquid Sharps

LSC (uCi) Added cucn CuCn 1/20/14 "H Tryptophan 0.6 19.1 0.3 1/23/14 "H Tryptophan 0.2 7.7 0.1

2/12/14 "H Tryptophan 0.4 9.4 0.2

2/21/14 "H Tryptophan 0.4 9.4 0.2

3/9/14 ... c Tryptophan 0.5 3.0 0.5

3/9/14 "H Tryptophan 0.4 9.4 0.2

5/2/14 ... c ... [C] KAR5202 0.2 0.1 1.7

7/15/14 "H Tryptophan 1.2 38.2 0.6

8/18/14 l"c 5-HT Binoxylate 0.5 4.4 0.1

8/18/14 l"c Tryptophan 0.5 4.4 0.1

8/19/14 "H Tryptophan 0.6 29.1 0.3 8/21/14 ... c 5-HT Binoxylate 0.1 0.8 0.1 8/28/14 l"c Tryptophan 0.5 4.4 0.1

8/28/14 l"c 5-HT Binoxylate 0.5 4.4 0.1

Solid (uCi) Liquid Sharps

LSC (uCi) TOTAL

cucn cucn Cuen Total 3H 3.8 122.3 0.0 1.9 128.0

Total 14C 2.8 21.5 0.0 2.7 27.0


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NRG FORM540 5. SHIPPER- NAME AND FACILITY SHIPPER ID# . NRC FORM540 AHO !i4CA. PAGE 1 _1_PAGE(S) 8. Manifest Number

Chase Environmental Group, Inc, NIA HRCFORM5'1 ANDli41A. OF _1_PAGE(S) (Use thJG hUmheir ori tll conflnlJsllon pagsa}

UNIFORM LOW·LEVEL RADIOACTIVE 11450 Watterson Court X !COLLECTOR NltC P'OJW.542 AND S42A _J_J>AGE(S)

WASTE MANIFEST Louisville, KY 40299 jPROC!;5SOR ADOITIONAL lNFOEWATIOM ~PAGE(S) AL-2015-006 SHIPPING PAPER USER PERMIT NUMBER 'SHIPMENT# G!N!AATOlt TVJ'!. (SPEC:ll'Y) 9. CONSIC3NEE-NAME AND FACIU'TY ADDRESS Contact

1. EMERC3ENCY TEl.£PHONE NUMBE (INCUJDE AREA CODEI T-KY003-L 14 NIA Alaron Corporation Mike otlowski 800-424-9300 CONTACT. TELEPHONE- 2138 State Route 18 Telephone Number (Include area code)

ORGANIZATION Seb Cannata 860~06-0195 Wampum, PA 16157 724-535-5777 Chemtrec WSDS #: CHEN01 RAD 6. CARRIER NAME AND ADDRESS EPAIO# Sl~TURE-Authorized conBiQne~ aoknowledging waste reoiept Date

?1S1H111Nr~uw~ r TOTAL NUMSER OF SJ Transportation Co., Inc. NJD071629976 [ ] YES PACKAGI;S IDENTIFIED 3 POBox169 SHIPPING DAlE 10. Certification x] NO ON THJS MANIFEST Woodstown, NJ oaosa 11912015 JMk190.,.,.o.tlhl.hlrallu•HIUl!ldll•-•"'*"do....,_~,.pKbped.lllallled,.INllUtltd-.,.ln~111Jitt--a...,nU111>11111io.~1

4. DOES BYo REBWA'Tm [ ]YES EPA MANIFEST NUMBER CONTACT TELEPHONE# llllU..IWi"""l•~af*"'i:i.o~afT~~--"""'lblh~;wwslioscih:l,~nimri;oridlPoi,.iM,,..ln

WAGn;R~tiAIWJfE31" [X] NO -Kevin Elder 855-769-2741 proptr0011iUlollltil!11111Jf*llil!Or\Jr.l...,.IU~iol- ..... h~'11"1:lCFR .. rtl.2D-ln.11f....-.al*lo!Jei1...,._

.. ,,, ..... ., .... .....,,.. NA s~· ~ D~fq{ 15 AUTHORIZED SIGN}\_TURE TITLE DATE I

rvt.-~ ~~ led\.. If q It" HM 11. U.S. OEPARTMENT OF TRANSPORTATION OESCFUPTION 12 13 14 t•' 1• 17 18., TOTALWEIGHT 19.10

{lncludlng proper&hlpping n211T11t, hazard class, UN to number. DDT LABEL TRANSPORT PHYSICAL AND INONIOUAL TOTAL PACKAGE LSA/SCO Ok VOLUME NUMBER OF

and any addltlonal ntDrmation} "''""'OAOllVE" INDEX CHEMICAL FORM RADIONUCUDES ACTMIY IN MBa CLASS mJ PACKAGE

Non DOT Regulated Material NA NA Liquid/Oxide C-14; H-3 5.32E+OO NA 0.019 AL-BL-W-15-014

One drum with llauid for disposal Non DOT Regulated Material NA NA Liquid/Oxide C-14; H-3 1.70E-01 NA 0.019 AL-VL-W-15-015

One drum with LSV for disposal Non DOT Regulated Material NA NA Solid/Oxide C-14; H-3 . 2.44E-01 NA 0.057 AL-CT-W-15-016

One drum with DAW for dlsposal -

-

..

.... Generator Certitlcaflon Statement: The constituents of the waste manifested herein are known to the generator. There are no EPA RCRA, pathogenic or other hazards present other than those specifically listed on the Form 541.

-~ fAn<._t(,il\ oo.ie~ ~lw_...-._ 1/c, /IS Print name Signature Date

CONSIGNEE ORIGINAL (M!.JST ACCOMPANY WASTE IN TRANSIT)

_,

J'lln.'V r-vri;1VJ ;;J't"I US NUCLEAR REGULA.TORY COMMISSION 1. 1ull-\1'111r ::~1 IV 1ri.1 S ;d. IYIJ""'ol'1ri;;;wl it'IU1V1~11;;;n

'"""'"°' NErWASYE NETWASTE SPECIAL NUCLEAR MATERIAL {grams) UNIFORM LOW-LEVEL RADIOACTIVE PACKAOE8 voL,,,,,., WGKT"' U-233 U-235 Pu TOTAL AL-2015-006

WASTE MANIFEST 3 0.095 15.0 NP NP NP NP 3. CONTAIHERANO WASTE DESCRIPTION 3.4 PAGE 1 OF _1 PAGE{Sl

ACTIVITY (MBq/mCI) SOURCE 4. SHIPPER NAME AU.. NUCLIDES TRITIUM C.14 Tc-99 ~129 (kal Chase Environmental Group

5.74E+OO MBa 4.74E+OO 9.99E-01 NP NP 0.00E+OO SHIPPER ID NUMBER

1.55E-01 mCi 1.28E-01 2.70E-02 N/A DISPOSAL CONTAINER DESCRIPTION WASTE DESCRIPTION FOR EACH WASTE TYPE !N CONTAINER 1utASTE

6. CONTAINER 6 7 B 9.SURFACE 1D • .SURFAOE PHYSICAL DESCRIPTION 14. CHEMICAL DESCRIPTION 15. RADIOLOGICAL DESCRIPTION. Cl.AS9

IOENTIFICATlON CONTAINER WASTE AND AAOlATIOI( CONTAMINATION 11.WASTE 12.~plmnwi 13.SOREEWT WflGHT IHDMOUALRAIONUaJDesANOAOTMTYtNBqlAHD AB-A8TA&.£

NUMBER/ OBSC!iiPrJoN VOIJJll!e CONTAllla. .t.EVEl MBq/100om2 DESCRIPTOR. WABT'EvtlLLIMe~ &OUDIPICATION OIEMlCAt.FORMI ~CHElAT~ COHTAINERTOTAL:ORCOtlTJ\ltERTO'r,IJ..ACTMTY AIMUN'STABLE

GENERAlOR (81effate1) ( m3) WEIGtrr _X_USv/hr !:!ETA- LN~ BTABIUV.TJO« ctlELAT1NGAGEITT ACi!Mf AHDRADIONUCUDEPERCENT 8-ClAS&!I

NUMBER (kg) mS•lllr AlJ'llA """""' (S.•N•o2J (m3) MEDIA(SH•d•3J IF•O.t'6 Nuclide MBa mCi CCIASSO

AL-BL-W-15-014 4 O.o19 4.0 <5.0 <3.67E-6 <3.67E-5 25 0.019 100 Oxide/NP NP C-14 7.96E-01 2.15E-02 NA 1183 ; H-3 4.53E+OO 1.22E-01

Package total 5.3;2E+OO 1.44E-01 AL-VL-W-15-015 4 0.019 5.0 <5.0 <3.67E-6 <3.67E-5 59 0.019 100 Oxide/NP NP C-14 9.99E-D2 2.70E-03 NA

1183 LSV H-3 7.03E-02 1.90E-03

Packaae total 1. 70E·ll1 4.6QE.03 AL-CT-W-15-016 4 0.057 6.0 <5.0 <3.67E-6 <3.67E-5 39 0.057 100 Oxide/NP NP C-14 1.04E-01 2.BOE-03 NA

1183 H-3 1.41 E-01 3.BDE-03

NOTE 1: Contain~ OescrlptiDn Codes. Fat cont!Ynm/

•slePqU1rS1r•J10S1lln~stnmtwal~cb.,

the numerlcal code must befolJO'VYed "by 0 0P ".

1,WDC>diibEIQl!Oi'Cla!I

' 2..M.lafbgll.

ll_pjglleOrurnarPsll

l4.MmilDrurncrP9ll

1S.MclalT111!corUnor

le. Conmts T;ri; or Un;•

.P~T91kmUn..-

8,fibiD'g)BsiQart.ar

s.1>6m!Mmrll:OI'

10..~Cylntbr

11.Buli.~~w..·

11..~gw:!Cnmpo!Mlnk

13.ff!Jjlilnte:!IJilyCanlaiflior

1D.Olh1r.drncrtiefnll1m8,

oriu:ldli-IP191

Package total 2.44E..01 6.60E·03

NOi 2: Wnt. DOIOllpm Oodm, (Chwsll lq:l IOV!.-'Mhlch i--~ bywlinm.} Nol13:Folsall~catlontriwdla111at1nHldispoMl11l11sttuctuflll~tyJG~rwncnll,U\ftnumorm11lOd1tlllll!tbll~l11·..e.•

20..Cbrrt:Dll

Zl.lrN:!ncinilorAsh

24StR

23.GI~

124.~

25. Aqb.mn;Uqt$d 1

2&. ~Mt4111 ;27. hh:lrilc:al ~r

i21.EPA!lf~•

" .......

:ZS. Dmio11~ Rufi:Jle :111L~r!l~.11llfl _,., Far .. ~ m11dla. Iha wrdar (nianllfactutwr) md brand l'QfN mml Dito bcl ldfttlltd In ltl:lm 1:9, ~• 1Qll• ((QNE. RE'QUIRED_

:ro. Callon Ion ED:hangtMe'lf•

31. Arffn km Exc:hang.:i Mocfl1 39.C11111~T9Nh Soqitk>n

31. Mlxod Bod Ion Eilchq• lrllcdl& «>. NonC'OITIPJdlbl .. Tl'll~ 60, Spead! Ori

61. Celetom n Cmtlm!M!ad !qdpm:nt.

34, °'PJlc Llq!ild (&clipt 011)

3S.G._.,C11'lmtlltfllre

36. S11l11f 4'wfCP:iDnk:f:

':J].PaJnlOl'!'bllrJJ

.fl.Anlna!Q:u=ss

CZ..l!!b!Gglca!M~~Ml'l'dloalB2. Aoororp c:..,_. Superfme

G. ktiw.Wid Miileiisl 63. Hi Ort

SB,Olh•f.Dolcltbokl~in11,cr

Mdldgm1lPai)I 1

64.Safe.-T-SDrb

65". Sl!lfe-N-Orf

.. ._ BT.l'lorc:oX

911.Sclid-A&lb

89.Ch.im)::JO

70.Chtmsls:I

71.Chamal3030

72..D~KP20D

.......... 7.1.[]f~/iP500 BS.Olliar.Dur.rb. !lCLC.m1nl

7.tlP11Jc11Gt hllm13,Q' ltl.Con::r-la{l:~

15.Pltrosatlf Mdltlonalpqo !r.i.Ellurn~

78.Aq- ID.Vinyl~!

71.AqlllMlll 94.~E!st&rS!)Mno

illl.Glt!w.o.c:riZJelnu.mi3, ........... _

1aa. Ng1111 .......

NRCFORM542 U.S. NUCLEAR RECOIJLATORY COMMISSION 1. WASTE COLLECTOR/PROCESSOR 2. M/>l!IFEST 1\1.JM BER

(S-199!1) NAME Sl-llPPER USE ONLY

UNIFORM LOW-LEVEL RADIOACTIVE Chase Environmental Grouo. lnc. AL-2015-006 WASTE MANIFEST IDENTIFIGA TION NUMBER

T-KYD03-L 14 3.

MANIFEST INDEX AND REGIONAL COMPACT TABULATION SHIPPING DATE PAGE_1_0F _1_PAGE(S)

Lisi al[ orlglnal 'PROCESSED WASTE!' before 'COLLECTED WAITTE'. 1/9/2015 4. 5. G. 7. .. B. 10. 11. Afl PROCESSED/COLLECTED TOTAL

GENEAATOR GENERATOR NAME GENERATOR PREPROC~SS50 MlltfHTNLJl.lll:R WASTE OR!llNA'lm

IOENTIFICA110N PERMIT NUMBER FACILilY WASTE UKlERWlfCtlWA.'iTI'! COOE """'"" A.SOURCE B.SNM C.ACTIVITY O.VOWME

NUM8ER AND TELEPHONE l'l.IM8ER ADDRESS !ORMATERW..J (ORIMlERAIJ ,_l'ltlaSSED OR MATERIAL

VOLUME RECBYCDNmllAlE C..CDt.U!Crtl> SW. (MBq) (m3)

"'31 "'""""' (kg) (g)

1183 Karos Pharmaceuticals 401 Winchester Ave. 0.095 NA c CT O.OOE+OO NP 5.74E+OO 0.095 New Haven, CT 06511

203-535-0540 ·,

-

..

TOTALS OF ALL PAGES (NRC FORMS 54ZAND 542A) l.__

0.000 0.000 5.74E+OO 0.095

.~ HRCFOllM5n(S-~

Waste Disposal Report - 29June 2017

___ ____ ___ __ _j:ombined Waste - 3t-!_~966.6 _ _g?S.6 _ 0.0 ~10.8 i 2253.0

--=- -~- ___ _::fc>mbined _:aste- 14~--=-3.3 _ l 112_4.4_: _DA ~1.5_1 ;!fu.5~ Total Combined Waste for Disposal I 3382.5

ste for Removal 2017 Inventory Wa

Solid Liquid Sharps LSC _C_L1Ci) - ~i) Date Isotope _ ________ . , _ I Chemical Form ___l!l_Ci) (2!14~~~---

Added -s:Hydroxy Trypramme 1- - - 3o.o : _ -r _-6/29/17 Deoxy-D-Glucose } 781.0 -

_ _j_ - ---

6/29/17 - S-l-Tryptophan _ - 43.0 -_ ~ -_ 6/29/17 - -,H -Meihyl-Thymidine_ - -- 36.0 ----- - - --, i

6/29/17 _ - L-Tryptoe_~ - 4~ -

6/29/17 -----;:c . A-Meth)ll:i,_-tryptoi>_han ' --,-_ 37.0 - '

6/].9/17_ I ----,,C:. __ I HYdroxy_Trypram111_e_~'-- t 92~_ ~ 6/29/17 -- 14~- - -__-K-CClOO~--:(~--~520_~ --- - - -- -12_ ___ : ----I '~~ -, ----i--6/26/01 _ ----- - - Ole1~_Ac1d___ ---- - __ --- LSC I

-

14

C -- -- . . Sharps . 6[f.'}_/17 _ - - _ _ _ _ __ -1

Solid I L1qu!d (uC:i) (uC1)_ --- i - - ! I (uCi) + (uC1) -- -~ -

1 , ---! : 1103.0 - · 20~7 TC.ta; Inve.;to.V:=~~ -~~I f 1049.0- ! - - -~ ' -----i-017Lotallnve!ltory~_ - -1- __::: - -.- - - - _-- -- =I- ---= -- ,

In - - -+ ---- --=- ' -- -' -- --- -- L" uid Waste

I ----+--- -- 12011 eo..;bTned Inventory 1q

TOTAL (uC:i) _ 1103.0 -1049.0

2152.0

2017 Waste for Removal

ADdadteed l Isotope Chemical Form Solid Liquid l Sharps II LSC ]

(uCi) (uCi) (uCi) (uCi) ; 1;1?;11 - 14c , OleicAcid -- o.5 - -~~3 ii---0.2 ;--

-~;~~)ii- :~ - i-_~:~:~:-1--~~ -1~1£~ - ~+f----j----~-- ---- -------- ----- ----- ____ ! ______ ·-;- . .. . .. -----~--

4/5/17 __ -~~ _ _ ___ T_hymadine --~ 20.6 ~- 0.1 __ +--+------

4/9{J.]__ ___ _____I~ymadine _ -~- _ 20,6_ I _ t- o._1 __ ____,____, __ _ 4/19/17

3H Thymadine 0.2 14.7 I 0.1

Sf3/1~ 1

-:__ 'H :__-=-~y_:adine__ 0.8 73.lT -1 _Q~-i ' ____ _

- __ i__ --~- --=--- -- _, ~~~- I - ~~~:: st.~~ 1- C~J ~

-----1-i

---~--

-----r-- ___ ____J_ I

2017 Total 3Hl 2.3 I 170.6 0.0 f___!_._1 __ 2011 T~tal 14C o.5 ---32.3 o.o · 0.2

----1

TOTAL _ (uCi)

174.0 ----

33.0

----·'----- -----+----1...----....i 2017 Combined Waste

! -t---+----i

207.0 I

[ _____ _

I


Date 1

t Chemical Solid Liquid Sharps i LSC Added so ope Form (uCi) (uCi) (uCi) (uCi) 3/23/16 -sR- Tr}tptophan 2.0 ----- - --

-c----t


Date I t Je I Chemical Solid ' Liquid Sharps LSC

-t~~-;-~- --- -S-03-=p-e- - -r_~_o __ t_:;han __ l_ -~ <r~_ .~_) -- _J ___ u-Ci} t- -{uCi) r _ -{~~-;> : _ I _ --- --_ -3L3/15 - _ - 3H -~' Tryptophan- ----- ~4.7 ---_-_--_ _ __ =r--__ -o.3 1 __ - --___ - _

_'}_j_~/1_5 _ _3_1-l_ Tryp~~phan_ ____J]__.7 __ . _ ___ _ _ _ 0.3 I- __ _

3/11/15 1 3H Tryptophan 59.4 0.6 ,

-3;13715 --~ - I Tryptophan s:3.1- I - -- -- ----- - 0.9 i --- -- 3/16/15 --3H - TrYptophan - - 59:4-----,---- ----- ---- --Q.6 ------

' __ _JI ____ _

4/7/15 3H i Tryptophan 55.4 I 0.6 i

-~~~~~ . :~--, ~~~:~~:~-~ -~~:j- - - .. -1 · -- :- ~f-1:-1-__ -__ --~I__ 0.6

I 0.3 I ---+--- -----+--+-----·

4/28/15 , 3H . Tryptophan 31.7 0.3

~;:Im- ~:~- ,H~~~~:~ y __ --~ -_ - ~ 1-~:~--~_,,-1- _-9/24/15 3H Tryptophan , 39.7 1

: 0.3

j : Solid. ' Uquid ' Sh•"'.+ ;c-----t------t--TOTAL -: - -__[_ n;t.11 'H ~ :i~ _' 1'5:~} l (~~} , (~~) ~~~;}_ = Total "c _ o.°_ __:_ J -=t Cl.Q_

1 __Q,Q_

---i - 2015 Combined Waste 1 974.0

NRCFORM540 5. SHIPPER· NAME AND FACILITY SHIPPER ID# 1. HRIC POflM 540 NMJ 5404 PAGE 1 _1_PAGE(S) e. Manifest Number Chase Environmental Group, Inc. NIA NRC FORM 541 NE541A OF _1_PAGE(S) (U..tt>lnumblr"1oll--)

UNIFORM LOW-LEVEL RADIOACTIVE 11450 Watterson Court X ICOLLECTOR ~ FOFlill542 NE EM2A _1_PAGE(S) WASTE MANIFEST Louisville, KY 40299 I PROCESSOR ACIXTIOIW. INFORMATJON l!.2nL_PAGE(S) AL-2017-221

SHIPPING PAPER USER PERMIT NUMBER ISHIPMENTI GENl!RATOR TYPt! (SPECll"Y) 9, CONSIGNEE-NAME AND FACILITY ADDRESS Contact

1. EMERGENCY TELEPHONE NUMBE (INCLUDE AREA C.OOE) T-KY003-L 17 NIA Alaron Corporation Mike Otlowski 800-424-9300 CONTACT TELEPHONE I 2138 State Route 18 Telephone Number (Include area code) ORGANIZATION Janet Baker 865-25G-4593 Wampum, PA 16157 724-535-5m CHEMTREC WSDS #: CHEN01 RAD Customer#: 4395 6. CARRIER NAME AND ADDRESS EPAID# SIGNATURE-Autharizad...-~-- Date ISTHISAH'UiCL~US£'.....an? ~ TOTAL NUMBER OF SJ Transportation Co., Inc. NJD071629976

[ 1 YES ~KAGES IDENTIFIED 2 PO Box169 SHIPPING DATE 1 o. Certification [x] NO ON THIS MANIFEST Woodstown, NJ 08098 612912017 This is to certify that the herein-named materials ere acceptable for disposal, are properly classified,

DOES EPA llBM .. ~.'IS> []YES EPA MANIFEST NUMBER CONTACT TELEPHONE II described, packaged. marl<ed, and labeled, and are In propar ccndllion for lnlnspollation accoiding to

Wit.8'!ER£QIJlllNGAMANIR!BT [x] NO Kevin Elder 856-769-2741 the applicable regulations of the Department of Transportation and the Commission.

Ac'.call'AHYTMSMPMEHr? NIA SIG!'ATUR~ /. , DATE AU.J!i"._D '.~IGNATURE TITLE DATE ;,2"(1£. ./ ... ~ .... ~ (,. - ;!"}-I 7 / ( 1,.:.l,4...--" ftt:.•1111,:t"->< / l.ln1/<:r (; - 2 'i - (7

HM 11. U.S. DEPARTMENT OF TRANSPORTATION DESCR,IPTION 12 13 ' 14 1s / , 18 17 18. TOTM.WEIGHT 19.10

(1--ohlppng ...... honrd-UNIDnumw. DOT LABEL TRANSPORT PHYSICAL AND INOMDUAL TOTAL PACKAGE LSA/SCO C><VOWIE NUMBER OF

.... ,,,,_inronnotionl '!!ACIC>ICTNE" INDEX CHEMICAL FORM RADIONUCLIDES ACTMTY IN MBq CLASS m3 PACKAGE Non DOT Regulated Material NIA NIA Solid/Oxide C-14; H-3 3.59E+01 NIA 0.212 AL-CT-W-17-319

One drum with SHARPS for disoosal Non DOT Regulated Material NIA NIA Solid/Oxide C-14; H-3 8.93E+01 NIA 0.114 AL-VL-W-17-320

One drum with vials and liauids for disoosal


Emergency Response Guide Reference: NIA

\i?~\,~l"-®"R\CIA Bc'U r<POSA rof zq/ 1 t-Karos Phannaceuticals Print name Date

CONSIGNEE ORIGINAL (MUST ACCOMPANY WASTE IN TRANSm

'"'v ·v""' - US NUCLEAR REGULATORY COMMISSION 1. Ul~•S 4' .... ""' .. " 1.ovl NUMl:St:t<

NUMBER OF NET WASTE NET WASTE SPECIAL NUCLEAR MATERIAL (grams) UNIFORM LOW-LEVEL RADIOACTIVE . ..,... .. VOl."""3 WGMT .. U-233 U-235 Pu TOTAL AL-2017-221

WASTE MANIFEST 2 0.326 Jl~i

NP NP NP NP 3. CONTAINER AND WASTE DESCRIPTION 11.5 PAGE 1 OF 1 PAGEfSl

ACTIVITY <MBQ/mCI) SOURCE 4. SHIPPER NAME ALLNUCUDES TRITIUM C-14 Tc-99 1-129 (k!l) Chase Environmental Group

1.25E+02 MBq 8.34E+01 4.18E+01 NP NP O.OOE+OO SHIPPER ID NUMBER 3.38E+OO mCi 2.25E+OO 1.13E+OO N/A

DISPOSAL CONTAINER DESCRIPTION WASTE DESCRIPTION FOR EACH WASTE TYPE IN CONTAINER 18.WASTE

5. CONTAINER e 7 8 8. SURFACE 10.SURFACE PHYSICAL DESCRIPTION 14. CHEMICAL DESCRIPTION 15. RADIOLOGICAL DESCRIPTION CU.SS

IDENTIFICATION CONTAINER WMTEAND RADIATION CONTAMINATION 11.WASTE 12.- 13.SORBENT WEIGHT INDIVIDUAL RAIOHUCLIDES AND ACTMTY (U8qJ AND ""'STABLE

NUMBER/ DESCRIPTION \/OLUME CONTAINER LEVEL MB<¥100cm2 DESCRIFTOR WASl'EVOLUa¥(.SJ SOLIDIFICATION CHEMICAL FORM I 'JI.CHELATING icoNTAINER TOTAi.: OR CONTAINER TOTALACTMTY AJJ-AUNSTABlE

GENERATOR (S..Noe.1) (m3) WE.OHT _x_uSv/hr BETA-~""'"'""'

STABU..IZATION CHELATING AGENT AGENT AND RADK>NUCUDE PERCENT BClASSB

NUMBER (kg) mSv/hr ALPHA """"' (S..NOC.2) (m3) MEDIA (See Nee. 3) IF~0.1% Nuclide MBa mCi C-CLASSC

AL-CT-W-17-319 4 0.212 <5.0 <3.67E-6 <3.67E-5 39,59 0.212 100 Oxide/NP NP C-14 1.37E-01 3.70E.03 NA 1183 if,::; SHARPS H-3 3.58E+01 9.67E.01

Packaae total 3.59E+01 9.70E..01 AL-VL-W-17-320 3 0.114 <5.0 <3.67E-6 <3.67E-5 25 0.114 100 Oxide/NP NP C-14 4.17E+01 1.13E+OO NA

1183 61) H-3 4.76E+01 1.29E+OO

Packaae total 8.93E+01 2A1E+OO

','·

NOTE 1: Container Description Codee. For containeJW

1--....-dilpoMlln~t:lrucluNI~ ,Ncilt2: w ... ~CodH. (ChoouuptottnllwNcfl ~byvolurM.) Not.3:For~medlllhltmMtdllpoealdltllNclurallbbllly~.lhe!IUflllflmlcodemllllbelallcJMdbr,<"-6."

(the numerical code must be followed by *oP •.

11. Woodin Bax orCNte

~--PlllticDNm«Plll

u.t.IDnmorPmil

u.t.iTdorllnlr

ConcftileTri«l.Mr

.~Tankorl.lnw

~TMkorllnet

··-10.G91C)irldlf

11. Bulk, UnpldalQld w.te

12.~CornpoNd:I

13. High Int.ply Cant.Iner

11.0lher.dllcrillftlln'IS.

or.tclllior.iJl90"

.a..·-... 2$.~Uqlllll ---27. M9chlnlc:alfll«

EPAarsmt. -

29. Dwrdlion Rubble

30. c.tlolt Ion Exdugt Medil

31. Anion Ion Eldmnge ......

32. ui:.d Bid Ion ~M9dil

33.~-34. Orpnlc LJcPd ~ Olf)

35.~orl..abirilwt

311. 6.-ct sou-i/O.W.

:fl.PlilntorPlllUna

38.EVlpCINl&oreottoma/Sludgel/

.,..__ F« d IOldllclitlDn rndil, the wndor (l1'lltllbc:t&nf Ind band nMnll rmlll allo be idMllll9d In bin 13. Code 100• NONE REQUIRED.

:!18.eom;.:tlbllTNlh

40.~Trah

41.Anirr*C...

Sooptian

[eo. Speedi Ori

161.Celetom

42. 8iolagieal-.rt.il (boeJCAnlmll cf62. Floor Ory/

ean:e. I Superftne .._ __ 59.0tla'. o.aibelnhmtt,or

............. 183. HI Ori

j64· Safe-T-Sarb

las. Slfe-N-Ori

... """" 67.flo<ooX ... ........_ e&.Cblrnsl30

70.ChtrnlllSO

71, a...n.113030

n.Olclper\HP.l«>

.......... 73. Obp9rf HPSOO 89. 00-. o.ci;bt "'·"'"""' , .. _

Slhm13,or Clt.Concrltl(Encaplulltlon)

75. PmQMlll -... .... 92 ........

78.AclU.C "'llh¥""""-77.~il 94.V~En~

•. OIMr. DIKslll In ...,, 13, «--

......... ·-

NRCFORM542 U.S. NUCLEAR REGULATORY COMMISSION 1. WASTE COUECTORIPROCESSOR 2. MANIFEST NUMBER

5-1998) NAME SHIPPER USE ONLY

UNIFORM LOW-LEVEL RADIOACTIVE Chase Environmental Group, Inc. AL-2017-221 WASTE MANIFEST IDENTIFICATION NUMBER

T-KY003-L 17 13.

MANIFEST INDEX AND REGIONAL COMPACT TABULATION SHIPPING DATE PAGE_1_0F _1_PAGE(S)

List all oliginal "PROCESSED WASTE" before "COLLECTED WASTE". 6/29/2017 14. 5. 8. 7. 8. 9. 10. 11. AS PROCESSED/COLLECTED TOTAL

GENERATOR GENERATOR NAME GENERATOR PREPROCESSED MANIFEST NUMBER WASTE ORIG~TING

IDENTIFICATION PERMIT NUMBER FACILITY WASTE l.N)ER WHICH WASTE CODE COMPACT A.SOURCE B.SNM C.ACTMTY D.VOLUME

NUMBER AND TELEPHONE NUMBER ADDRESS (OR MATERIAL.) (atMArauN..) .....,..... OR MATERIAL

VOLUME RECelYED AND Do\TE ""'""""' ST•TE (MBq) (m3)

(m3) OFRE<EJPT (kg) (g)

1183 Karos Pharmaceuticals 401 Winchester Ave. 0.326 NA c CT O.OOE+OO NP 1.25E+02 0.326 New Haven, CT 06511

203-535-0540

TOTALS OF ALL PAGES (NRC FORMS 542 AND 542A)

0.000 0.000 1.25E+02 0.326

lflC~542~1Q88)

GENERATOR AUTHORIZATION

DATE: 06/29/17

NAME OF ORIGINAL GENERATOR: Karos Pharmaceuticals Authorizes

NAME OF BROKER/PROCESSOR: Alaron Nuclear Services

to be our Broker and/or Processor for disposal of our radioactive material and/or sealed sources into the State of Texas Compact Disposal Facility in Andrews, Texas, operated by Waste Control Specialists, LLC. By signing this Generator Authorization, the Generator is also verifying that there is no waste of international origin contained in this shipment.

NAME OF AUTHORIZED ORIGINAL GENERATOR REPRESENTATIVE: Patricia Bourassa

TITLE: Radiation Safety

MAILING ADDRESS: 401 Winchester Ave.

New Haven, CT 06511

SIGNATURE:~~A..J,.~

TLLRWDCC Gen Auth 110912

DISPOSAL OF LIQUID SCINTILLATION COUNTER

The following GLD was removed and disposed Radiac Environmental Services on 13 July 2017:

Instrument:

Manufacturer:

Model:

Serial Number:

Source:

Activity:

Manufacture Date:

Tri-Garb liquid scintillation counter

Perkin Elmer

3100TR

433858

BA-133

18.8 ± 17% uCi

11-1-2003


. . . . I ***** CONTAINS HAZARDOUS MATERIALS ***** .

~rodi.M Non-Negotiable I ~ REs1aacH coaP. STRAIGHT BILL OF LADING~

NYSDEC: 2A-004 43593 *DOT Reg. No: 051303 009 011LN * NYS DOH License: C-19441 No. 17124-T/B I 261 Kent Avenue

OF 1 Brooklyn, NY 11249 Phone (800) 640 - 7511 Fax (718) 388 - 5107

--- ---

Driver:

RADIAC RESEARCH CORP.

S H I P P E R (ORIGIN) C 0 NS I G NEE (DESTINATION) NOTES Name KAROS PHARMACEUTICALS (NRC Lie. 31-31441-01) Name RADIAC RESEARCH CORP. street Address 5 SCIENCE PARK# 2 Street Address 261 KENT AVE. City, state NEW HAVEN, CT 06511 City, State BROOKLYN, NY 11249 Notify/Contact Mr, ROBERT AIELLO (203) 535 • 0540 x 205 Notify/Contact JOSEPH SPEKTOR (718) 963 • 2233 x205

PARTICULARS FURNISHED BY SHIPPER

Units HM Description, Proper Shipping Name Hazardous UN/NA Packing Weight 0 Class Number Group Lbs.

" 1 " 0 UN2911, Radioactive material, excepted package - instruments I I I -600 I N/A IN/A NA I

[SCINTILLATION COUNTER Tri-Carb MODEL 3100 TR (s/n 433858) I I I FOR DISASSEMBLING I RECYCLING I DISPOSAL] I

I I I

CONTAINING INTERNAL SOURCE I I I Ba-133, 7.37 uCi (originally 18.8 uCi as of 11/1/2003) I I I I

I I I

I I I I

I Placards Required: ,

SHIPPER'S CERTIFICATIONS (Furnished by Carrier) YES D N0(2] I Emergency Response Phone: j ERG No.: Chemtrec: (800) 434-9300 161

This is to certify that the above-named materials are properly classified, described, packaged, marked and labeled, and are in proper condition for transportation according to the applicable regulations of the Department of Transportation (49 C.F.R. §172.204).

All materials are packaged in containers Type IP-1 (49 C.F.R. §173.403 & §173.411 ). €gnatur;'°\

Special Instruction: Shipper confirms that necessary wipe tests have been performed and as a result the unit does not show any radioactive contamination.

CONSIGNEE:

Received in good order, count and condition ~ unless otherwise noted above.

~ . (Print Name) . , ' (Print Name)

I (A"th"""" s;Q,:tmo) . ~. _,/.: :',- ',:;~,:;~~ s;,;.,,.,; ,. •.. " • (A,thoriZOdSlgo.t""'i Monitored at all times the Hazardous Material is in transportation including storage incidental to transportation (172.604)

I ***** CONTAINS HAZARDOUS MATERIALS ***** I ~ Non-Negotiable I ~ RESEARCH CORP. STRAIGHT BILL OF LADING~

NYSDEC: 2A-004 43593 *DOT Reg. No: 051303 009 011LN * NYS DOH License: C-19441 No. 17124-T/8 I 261 Kent Avenue Brooklyn, NY 11249 Phone (800) 640 - 7511 Fax (718) 388 - 5107

OF 1 --- ---

Driver:

RADIAC RESEARCH CORP.

S H I P P E R (ORIGIN) C 0 NS I G NEE (DESTINATION) NOTES Name KAROS PHARMACEUTICALS (NRC Lie. 31-31441-01) Name RADIAC RESEARCH CORP. street Address 5 SCIENCE PARK# 2 Street Address

261 KENT AVE. City, state NEW HAVEN, CT 06511 City, State BROOKLYN, NY11249 Notify/Contact Mr. ROBERT AIELLO (203) 535 • 0540 x 205 Notify/Contact JOSEPH SPEKTOR (718) 963 -2233 x205

PARTICULARS FURNISHED BY SHIPPER

Units HM Description, Proper Shipping Name Hazardous UN/NA Packing Weight 0 Class Number Group Lbs.

• 3 - EJ UNQUENCHED LIQUID SCINTILLATION STANDARDS I I ~1

I N/A IN/A NA I (PERKIN ELMER - 3 VIALS) FOR I I I EVALUATION/RECLAMATION/RECYCLING/DISPOSAL I

I I I

NRC EXEMPT QUANTITIES <0.2 uCi of H-3 & < 0.1 uCi of C-14 I I I I I I I

I I I

I I I I

I Placards Required: D

SHIPPER'S CERTIFICATIONS (Furnished by Carrier) YES No El I Emergency Response Phone: I ERG No.: Chemtrec: (800) 434-9300 161

This is to certify that the above-named materials are properly classified, described, packaged, marked and labeled, and are in proper condition for transportation according to the applicable regulations of the Department of Transportation (49 C.F.R. §172.204). All materials are packaged in containers Type IP-1 (49 C.F.R. §173.403 & §173.411).

I Special Instruction:

~~ i?o he tt A,.e.t ( Q

~ ___ ,..e0£,,,

CONSIGNEE:

Received in good order, count and condition ~ unless otherwise noted above.

(Print Name)

~ ~ri=me)Q (Authorized Signature) (Authorized Signature) (Authorized Signature)

Monitored at all times the Hazardous Material is in transportation including storage incidental to transportation (172.604)

RADIAC ENVIRONMENTAL SERVICES, 261 Kent Avenue, Brooklyn, NY 11249 * (718} 963-2233 Fax (718) 388-5107

July 5, 2017

VIA: Email

Karos Pharmaceuticals 5 Science Park # 2 New Haven, CT 06511 (203) 535-0540

Email: [email protected] Ph: (203) 535-0540 Ext: 205

Re: Evaluation I Reclamation I Recycling & Disposal of LCS unit.

Dear, Mr. Aiello

Radiac Environmental Services is pleased to provide the following price quotation for the specification referenced above:

Labor, Materials, Transportation, Recycling, Disposal

Total Estimate

$3,250

$ 3,250

Standby and/or Out of Scope Services:

(Includes cost for on-site operation and removal for Evaluation I Reclamation I & Disposal ofLCS unit)

Standby for delays not caused by Radiac Environmental Services and out of scope services will be billed at the following rates:

Assumptions:

All above pricing is based on the following assumptions

1. Instrument does not exceed ( 1) LSC for evaluation for source reclamation, instrument recycling I reuse. Once unit received, we will disassemble it, remove the radioactive source (this source will remain in out possession), and entire unit including all internal components will be shipped for recycle I reuse. Radiac is a fully licensed facility to accept such material (NYS DOH License # Cl944, Item 9A). We will try to find another licensee who is willing and able to take this source for insertion into a refurbished liquid scintillation counter. In case the re-use option will not be available, Radiac will send this source via our licensed processor for ultimate land burial at WCS facility in Andrews, TX.

2. The Generator will provide a representative to sign all necessary recycling documentation.

3. Waste must be accessible on a first floor, loading dock and/ or solid surface. Any special arrangements must be made in advance.

4. Radiac Environmental Services (or any other entity) cannot, according to the requirements of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), take title to waste from a generator.

5. All processing and packaging materials quoted are in accordance with Radiac' s interpretation of the disposal request. Additional packaging and processing requirements not specifically stated in the bid specification will entail additional charges in accordance with the rate schedule.

6. Payment terms are C.O.D upon removal of instrument.

This quote is in full compliance with the job specification referenced above, except where the specification may be in conflict with the noted assumptions.

If you have any questions, please do not hesitate to call.

Sincerely,

RADIAC ENVIRONMENTAL SERVICES

John V. Tekin, Jr. Operations Mgr.

I authorize Radiac Research Corp. To proceed with the proposal outlined in the quotation. I also understand that any out of scope services will be billed in accordance with Radiac's standard rate schedule. I have also enclosed all credit card information that is required for Radiac to receive full payment for these services.

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6/2B/2017 2:30:38 PM QuantaSmart (TM) - 2.02 - Serial# 433858 Page # 1

Protocol# 1 - dUEL SWIPE.lsa User: RJA

Assay Definition-

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Assay Type: DPM (Dual) Report Name: Reportl Output Data Path: C:\Packard\Tricarb\Results\RJA\dUEL SWIPE\20170628 1238 Raw Results Path: C:\Packard\Tricarb\Results\RJA\dUEL SWIPE\20170628-1238\20170628 1238.results Assay File Name: C:\Packard\TriCarb\Assays\dUEL SWIPE.lsa

Count Conditions-

Nuclide: 3H-14C Quench Indicator: tSIE/AEC External Std Terminator (sec): 0.5 2s% Pre-Count Delay (min): 0.00

Quench Sets: Low Energy: 3H Mid Energy: 14C

Count Time (min): 1.00 Count Mode: Normal Assay Count Cycles: 1 #Vials/Sample: 1

Background Subtract: Off Low CPM Threshold: Off 2 Sigma % Terminator: Off

Regions A B c

LL 0.0

12.0 0.0

Count Corrections-

UL 12.0

156.0 0.0

Static Controller: On Colored Samples: Off Coincidence Time (nsec) : 18

Half Life-

Half Life Correction: Off Regions Half Life A B c

Cycle 1 Results S# Count Time CPMA

1 1. 00 1 2 1. 00 0 3 1. 00 6 4 1. 00 6 5 1. 00 3 6 1. 00 11 7 1. 00 6 8 1. 00 7 9 1. 00 6

10 1. 00 3 11 1. 00 10

Repeat Sample Count: 1 Calculate % Reference: Off

Luminescence Correction: On Heterogeneity Monitor: n/a Delay Before Burst (nsec): 75

Units Reference Date

CPMB DPMl DPM2 SIS 10 0 12 136. 35 11 0 14 39.32

5 12 5 21. 01 3 13 3 12.32 5 5 6 21. 8 9 9 23 10 17.78

10 11 11 36.70 7 14 8 20.06

10 10 11 54.28 5 4 6 39.67 5 21 5 17.35

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Reference Time

tSIE MESSAGES 446.78 - BLAIVK 481.84 4 96. 22 484.77 493.92 470.34 494.34 490.56 558.43 524.92 502.73

6/i8/2017 2:30:38 PM QuantaSmart (TM) - 2.02 - Serial# 433858 Page # 2


12 1. 00 11 8 23 8 38.62 505.81 13 1. 00 5 8 9 9 24.30 500.23 14 1. 00 9 7 17 7 31.70 535.81 15 1. 00 17 7 35 6 20.50 522.57 16 1. 00 10 7 21 7 19.81 495.44 17 1. 00 2 7 2 8 42.06 501.58 18 1. 00 4 9 6 10 58.30 561.37 19 1. 00 4 11 6 13 42.44 508. 96 20 1. 00 2 4 3 5 20.78 542.47 21 1. 00 5 9 8 10 80.14 534.17 22 1. 00 3 5 5 6 39.86 494.15 23 1. 00 9 6 18 6 12.78 520.05 24 1. 00 10 12 18 13 36.81 532.46 25 1. 00 7 11 11 13 2 9. 88 519.30 26 1. 00 5 11 9 12 52.88 512.12 27 1. 00 5 5 8 6 47.88 519.86 28 1. 00 5 5 10 5 24.99 478.81 29 1. 00 8 8 15 9 31. 41 484.46 30 1. 00 4 7 7 8 37.21 504.20 31 1. 00 2 6 3 7 43.74 502.22 32 1. 00 3 8 4 9 77.99 516.95 33 1. 00 10 6 21 6 17.85 495.86 34 1. 00 2 8 2 9 42.27 489.70 35 1. 00 0 6 0 7 52.74 506.71 36 1. 00 9 6 20 5 9.87 469.54 37 1. 00 8 7 14 8 33.44 519.98 38 1. 00 7 6 14 6 30 .11 555.09 39 1. 00 3 5 5 6 24.88 537.70 40 1. 00 5 8 9 9 68.46 495.56 41 1. 00 6 2 13 2 9.45 4 97. 96 42 1. 00 6 4 13 4 20.56 454.30 43 1. 00 4 10 6 12 54.33 489.13 44 1. 00 2 13 0 16 50.11 497.83 45 1. 00 4 6 7 7 28. 71 481. 01 46 1. 00 1 8 0 10 49.58 475.21 47 1. 00 0 6 0 7 101.69 4 65. 96 48 1. 00 0 7 0 9 83.30 491.39

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Assay Definition-

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2 B :JU\-....E 2oi 1-Assay Description:

Assay Type: DPM (Dual) Report Name: Reportl Output Data Path: C:\Packard\Tricarb\Results\RJA\dUEL SWIPE\20170628 1458 Raw Results Path: C:\Packard\Tricarb\Results\RJA\dUEL SWIPE\20170628-1458\20170628 1458.results Assay File Name: C:\Packard\TriCarb\Assays\dUEL SWIPE.lsa

Count Conditions-

Nuclide: 3H-14C Quench Indicator: tSIE/AEC External Std Terminator (sec): 0.5 2s% Pre-Count Delay (min): 0.00

Quench Sets: Low Energy: 3H Mid Energy: 14C

Count Time (min): 1.00 Count Mode: Normal Assay Count Cycles: 1 #Vials/Sample: 1

Background Subtract: Off Low CPM Threshold: Off 2 Sigma % Terminator: Off

Regions A B c

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Cycle 1 Results

Repeat Sample Count: 1 Calculate % Reference: Off

Luminescence Correction: On Heterogeneity Monitor: n/a Delay Before Burst (nsec): 75

Units Reference Date

S# Count Time CPMA CPMB DPMl DPM2 SIS 1 1. 00 2 7 3 8 66.07 2 1. 00 10 12 17 13 27.49 3 1. 00 8 17 13 19 46.74 4 1. 00 12 7 25 7 12.04 5 1. 00 11 8 21 8 26.77 6 1. 00 13 8 25 8 26.90 7 1. 00 8 5 16 5 21. 58 8 1. 00 3 8 4 9 39.15

Reference Time

tSIE MESSAGES 449.41 B~K. 573.60 543. 96 504.64 551.84 528.63 517.30 523.51

KAROS - STATIC SURVEY READINGS --,----------~------- -------------. _j_ __ _ ---+

LAB GRID # I Counts/ Sec LAB GRID # I Counts/ Sec LAB GRID# I Counts/ Sec

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!f9KAA,0S b PHARMAC:8UT'ICALS

Annual Review of Practices

DATE: 12 December 2011

AUDITED: Training & Safety Procedures

Radiochemical storage

Waste management

Documentation

RESULTS: No discrepancies found in the program

No spills and/or accidents were reported in 2011

NRC inspection found no discrepancies in the program

REVIEWED BY: t;(etv~ 12. DH.. UH I

5 Science Park• New Haven CT 06511-1989 USA 8 203-535-0540 • Fax 203-891-5156

!'lrKAR0S b -RMACSV'l'ICALS





Waste management

Documentation



REVIEWED BY: ~\A./leA..A-----


!f.KAA,0§ «::::> PMARMAC:IVflCAl.S





Waste management

Documentation



REVIEWED BY: f3.J:l}U./~


!fKAA0S b PHA~MAC:Wvn<:ALS





Waste management

Documentation



REVIEWED BY: +6._,~'L/\ .. -9---






Waste management

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Waste management

Documentation



Training slide deck was updated for conciseness

NRC spot inspection found no issues with program

REVIEWED BY:

5 Science Park• New Haven CT 06511-1989 USA 2l 203-535-0540 • Fax 203-891-5156

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RIORITY®

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DATE OF DELIVERY SPECIFIED*

USPS TRACKING™ INCLUDED*

INSURANCE INCLUDED*

PICKUP AVAILABLE

* Domestic only

~USED INTERNATIONALLY, :USTOMS DECLARATION BEL MAY BE REQUIRED.

111 11111111111111111111 00001000014

EP14F July 2013 OD: 12.5 x 9.5

. iif!!!f!f UNITED sr/lrEs. c 1-1 ck-N-S h ·1 P® W... POSTIJ.LSERVICE®

$sC.~~om 9405 8036 9930 0479 0963 51 0066 5000 0031 9406

~~,~=:~~· llll~~ii~~ll~llllll 07/19/2017 Mailed from 06511 062S0000000315

PRIORITY MAIL 2-DA Y™ LISAA REHM Expected Delivery Date: 07 /21 /17

Ref#: Disp. Mat. KAROS PHARMACEUTICALS 401 WINCHESTER AVE STE2 NEW HAVEN CT 06511

0006

lco22I SHIP

TO: US NUCLEAR REGULATORY COMMISSION, REGION 1 2100 RENAISSANCE BLVD STE 100

KNG OF PRUSSA PA 19406-2713

USPS TRACKING #

9405 8036 9930 0479 0963 51

Electronic Rate Approved #0385557 49

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NRC FORM 532 U.S. NUCLEAR REGULATORY COMMISSION (05-2016) .;:,C,,,.rc>Rl'IEG(l{'f~

flJ~- 0'1>

~ ~ ACKNOWLEDGEMENT - RECEIPT OF CORRESPONDENCE ~ •. , lt

~ f ........ ") +o-t' .......

Name and Address of Applicant and/or Licensee Date

I July 24, 2017 I License Number(s)

Karas Pharmaceuticals, Inc. I 31-31441-01 I ATTN: Robert J. Aiello, Ph.D. Mail Control Number(s) 7 Times Square I 600290 I New York, NY 10036

Licensing and/or Technical Reviewer or Branch

Commercial, Industrial, R&D, & Academic Branch (Branch 2)

This is to acknowledge receipt of your: 0 Letter and/or D Application Dated: 07/18/2017

The initial processing, which included an administrative review, has been performed.

D Amendment [ZJ Termination D New License D Renewal

0 There were no administrative omissions identified during our initial review.

D This is to acknowledge receipt of your application for renewal of the material(s) license identified above. Your application is deemed timely filed, and accordingly, the license will not expire until final action has been taken by this office.

D Your application for a new NRC license did not include your taxpayer identification number. Please complete and submit NRC Form 531, Request for Taxpayer Identification Number, located at the following link: http_;.lLwww._nr~,_gov/reading-rm/dQC'.'.'collectionsLforms/nrc531.pdf

Follow the instructions on the form for submission.

D The following administrative omissions have been identified:

Your application has been assigned the above listed MAIL CONTROL NUMBER. When calling to inquire about this action, please refer to this control number. Your application has been forwarded to a technical reviewer. Please note that the technical review, which is normally completed within 180 days for a renewal application (90 days for all other requests), may identify additional omissions or require additional information. If you have any questions concerning the processing of your application, our contact information is listed below:

Region I U. S. Nuclear Regulatory Commission Division of Nuclear Materials Safety 2100 Renaissance Boulevard, Suite 100 King of Prussia, PA 19406-2713 (610) 337-5260, (610) 337-5313, (610) 337-5398, or (610) 337-5239

NRC FORM 532 (05-2016)

Karos Pharmaceuticals, Inc.; Termination Request Letter ... · nift code: pnccus33 outing #...

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Transcript of Karos Pharmaceuticals, Inc.; Termination Request Letter ... · nift code: pnccus33 outing #...