K7-Biochemistry of Blood Brain Barrier.pptx

7/26/2019 K7-Biochemistry of Blood Brain Barrier.pptx

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Biochemistry of BloodBrain Barrier (BBB)Biochemistry of BloodBrain Barrier (BBB)

Dr. Hidayat


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LEARNING O JECTIVE

EARNING O JECTIVE

To explain :

Blood - Brain Barrier

Blood - CSF Transport

CSF - Brain Transport


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BRAINBRAIN


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CEREBRAL VENTRICLECEREBRAL VENTRICLE

4 ventricles in brain (two lateral, third and fourth)

Membrane bound cavities lined with ependymal cells.

Filled with CSF (1mm!" pressure)


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CEREBRO!INAL "L#I$ (C")CEREBRO!INAL "L#I$ (C")

Composition different to plasma

lower protein

hi"her #a$lower %$

&ives protection (mechanical

and chemical)'y circulatin" it echan"es

nutrients and wastes


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Menin"eal Membranes and Cerebrospinal FluidMenin"eal Membranes and Cerebrospinal Fluid

ura mater

*rachnoid mater

+ia mater

hree menin"eal membranes

+rotective function and involved in the production and reabsorption of CSF


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Menin"eal Membranes and CSF- 'rainMenin"eal Membranes and CSF- 'rain

ura mater

Sa"ittal sinus (ural sinus)

*rachnoid mater

Subarachnoid space

+ia mater

wo important cavities (spaces) within the menin"eal membranes

n addition to CSF in ventricles//.

CSF circulates throu"h the subarachnoid space and is reabsorbed into the Sa"ittal

(ural) sinus


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0hat is 'lood 'rain 'arrier 0hat is 'lood 'rain 'arrier

#ot a sin"le barrier but a collection of physical

and physiolo"ical barriers that limit the entry of

compounds into the C#S


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Formed by brain microvascular endothelialcells (B!C"# astrocyte end $eet andpericytes

!ssential $or normal $unction o$ C%S

&e'ulates passa'e o$ molecules in and out

o$ brain to maintain neural environment. &esponsible $or metabolic activities such as

the metabolism o$ -dopa to re'ulate its

concentration in the brain.


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Blood Brain BarrierBlood Brain Barrier


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Brain Ca%illaryBrain Ca%illary


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$ifferences &et'een BEC and normalendothelial cells

$ifferences &et'een BEC and normalendothelial cells

Structural di$$erences: )bsence o$ $enestrations ore extensive ti'ht *unctions (T+"

Functional di$$erences: ,mpermeable to most substances Sparse pinocytic vesicular transport

,ncreased expression o$ transport and carrierproteins: receptor mediated endocytosis %o 'ap *unctions# only ti'ht *unctions imited paracellular and transcellular transport


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Tiht J*nctionTiht J*nction


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olec*l Trans%ort in BBBolec*l Trans%ort in BBB


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CLINICAL CORRELATIONCLINICAL CORRELATION

ernicterus


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CLINICAL CORRELATIONCLINICAL CORRELATION

ar/inson0s Disease


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Terima /asih

K7-Biochemistry of Blood Brain Barrier.pptx

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