K10- Plasmodium Falc Dan Vivax

8/13/2019 K10- Plasmodium Falc Dan Vivax

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Plasmodium spp.

Parasitology Dept.


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Malaria-endemic Areas 2000


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PlasmodiumsTerminology

PhylumApicomplexa

Subphylum Sporozoa

Class Telosporea

Subclass Hmosporina

Family Plasmodiid

Vectored primarily by femaleAnopheles

mosquito


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Anophelesvector of

Plasmodiums


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Sporogonous Cycle:

Mosquito Stages

Gametocytes

P. falciparum

P. vivax

P. ovale

P. malariae

Human Liver Stages

Exo-erythrocytic

(hepatic) Cycle:

Human lood Stages

Erythrocytic Cycle:

Malaria Lifecycle


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Plasmodium vivax


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Plasmodium vivaxGeneral

Synonims: Haemamoeba vivax,Plasmodium malariae tertiana

Prepatent period: 8-17 days (depends onthe number of inoculated sporozoits andstrain), usually 14 days

Prepatent period is also called biologicalincubation period: the period requiredsince sporozoits enter a human until it isdemonstrated in the blood stream


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Plasmodium vivaxMorphology in Stained Preparation

Ring form : blue-

stained ring of

cytoplasm with a redchromatin dot

Late ring form:

stippling (Schuffnersdots) appear, no

pigment yet


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The early erythrocytic

trophozoit : blue-

stained cytoplasmwith a red chromatin

dot, stippling and

pigments appear,enlarged infected

RBC


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Mature trophozoit: the

plasmodium enlarge,the sitoplasm becomes

irregular and larger

(amoeboid), stipplingand pigments (+)


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Schizont: progressive

steps in division

(presegmenting)

Mature schizont: consist

of 8-24 merozoits,

usually 12-18


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Macrogametocyte: female gametocyte,

stains deep blue, smaller nucleus,

chromatin is arranged in a compactmass near the periphery

Microgametocyte: male gametocyte,

stains pale blue, larger nucleus, thechromatin is irregularly situatedwithin

the cytoplasm


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Plasmodium vivaxMorphology of all stadiums


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Plasmodium falciparum


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Plasmodium falciparumGeneral

Synonims: Plasmodium tropica

Prepatent period: minimal 5 days,

average 8-12 days


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Plasmodium falciparumMorphology in Stained Preparation

Ring form: vary in

shape; doublechromatin, double

infection, accole


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Trophozoit: rare in

peripheral blood afterhalf grown, infected RBC

is normal sized, stippled

(Maurers dots) and

pigmented

Note at the Maurers dots


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Schizont: consist of 8-26 merozoits,

usually 8-18, rare in peripheral blood


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Microgametocyte: sausage shape,chromatin diffuse, large nucleus

Macrogametocyte: longer and moreslender, central chromatin, pigment andnucleus more compact


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Plasmodium falciparumMorphology of all stadiums


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Pictures of P. falciparum


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Thank You

K10- Plasmodium Falc Dan Vivax

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