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8/13/2019 Jurnal RSC
http://slidepdf.com/reader/full/jurnal-rsc 1/18
Jurnal RSC
Etika Profesi dan Kapita Selekta.
Dosen
Drs. Edi Wahyu Sri Mulyono, MS, Apt., MT
Nadia Annisa Fajriana 121431017
Nadya Mawartiani 121431018
Riska Purwanti 1214310xx
Rusydiana Abdullah 121431023
Tanty 121431026
Wahidin 1214310xx
Yufi Mutia 1214310xx
PROGRAM STUDI D3-ANALIS KIMIA
JURUSAN TEKNIK KIMIA
POLITEKNIK NEGERI BANDUNG
2013
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1. Chemical Science
Impact factor : 8314 12 issues per year
Paper : Organocatalytic C –H hydroxylation with Oxone ® enabled by an aqueous
fluoroalcohol solvent system
Ashley M. Adams and J. Du Bois
Abstract :
Selective hydroxylation of 3° and benzylic C –H bonds is made possible using a non-
metal-based catalyst system, Oxone as the terminal oxidant, and an aqueous
fluoroalcohol solvent mixture. The choice of solvent is uniquely effective for this process,
but seemingly at odds with our finding that H 2O promotes reduction of the oxaziridine
intermediate. Our studies suggest that the hydroxylation reaction is occurring within a
fluoroalcohol microdroplet, which both concentrates the reactants and mitigates the
deleterious impact of H2O on oxaziridine stability. These discoveries have led to
demonstrable improvements in the organocatalytic oxygenation of hydrocarbon
substrates and, for the first time, the successful use of Oxone with this catalyst system.
Reactions generally afford product and unreacted starting material in near quantitative
amounts and display outstanding selectivity for 3° and benzylic C –H bond oxidation.
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Isi :
Menjelaskan tentang Hidrokalbon selektif dari ikatan 3° and benzylic C –H membuat
menggunakan non logam berdasarkan system katalis menjadi mungkin, Oxone sebagai
pangkal oksidan, dan campuran pelarut cairan fluoroalkohol . Pilihan pelarut benar
benar efektif untuk proses ini, tetapi tampaknya aneh dengan kita menemukan bahwa
H2O menaikkan reduksi dari oxaziridine . pembelajaran kita menyarankan bahwa reaksi
hidroksilasi terjadi dalam fluoroalcohol microdroplet , dimana kedua konsentrat reaktan
dan mengurangi dampak yang merusak H 2O dalam stabilitas oxaziridine. Penemuan ini
telah dipimpin untuk perbaikan nyata dalam oksigenasi organokatali pada substrat
substrat hidrokarbon dan untuk yang pertama, kesuksesan mengggunakan oxone
dengan system katalis ini. Reaksi reaksi umum memberi produk dan tidak bereaksi mulai
dari bahan yang mendekati jumlah kuantitatif dan menampilkan selektifitas yang luar
biasa untukikatan oksidasi 3° and benzylic C –H.
2. Dalton Transaction
Impact factor : 3806 48 issues per year
Paper : Structural rearrangements induced by acid –base reactions in metal carbonyl
clusters: the case of [H 3−nCo15Pd9C3(CO)38]n− (n = 0 –3)
Iacopo Ciabatti, a Cristina Femoni, a Mattia Gaboardi, b Maria Carmela
Iapalucci, a Giuliano Longoni, a Daniele Pontiroli, b Mauro Riccò b and Stefano
Zacchini *a
Abstract :
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The new bimetallic [HCo 15Pd9C3(CO)38]2− tri-carbide carbonyl cluster has been obtained
from the reaction of [H 2Co20Pd16C4(CO)48]4− with an excess of acid in CH 2Cl2 solution. The
mono-hydride di-anion can be reversibly protonated and deprotonated by means of
acid –base reactions leading to closely related [H 3−nCo15Pd9C3(CO)38]n− (n = 0 –3) clusters.
The crystal structures of the three anionic and the neutral clusters have been
determined as their H 3Co15Pd9C3(CO)38 ·2thf, [NEt 4][H2Co15Pd9C3(CO)38]·0.5C6H14,
[NMe 3(CH2Ph)] 2[HCo15Pd9C3(CO)38]·C6H14 and [NEt 4]3[Co15Pd9C3(CO)38]·thf salts. They are
composed of a Pd 9(μ3-CO)2 core stabilised by three Co 5C(CO)12 organometallic
fragments. The poly-hydride nature of these clusters has been indirectly
inferred via chemical, electrochemical and magnetic measurements. Besides, cyclic
voltammetry shows that the [H3−n
Co15
Pd9C
3(CO)
38]n− (n = 1 –3) anions are multivalent,
since they undergo two or three reversible oxidations. SQUID measurements of
[HCo15Pd9C3(CO)38]2− indicate that this even electron cluster is paramagnetic with two
unpaired electrons, giving further support to its hydride nature. Finally, structural studies
show that the Pd 9 core of [H 3−nCo15Pd9C3(CO)38]n − (n = 0,1) is a tri-capped octahedron,
which becomes a tri-capped trigonal prism in the more charged
[H3−nCo15Pd9C3(CO)38]n− (n = 2,3) anions. Such a significant structural rearrangement of
the metal core of a large carbonyl cluster upon protonation –deprotonation reactions isunprecedented in cluster chemistry, and suggests that interstitial hydrides may have
relevant stereochemical effects even in large carbonyl clusters.
Isi :
Menjelaskan tentang Bimetal baru [HCo 15Pd9C3(CO)38]2− gugus tiga- karbonil karbida
telah diperoleh dari reaksi [H 2Co20Pd16C4(CO)48]4− dengan kelebihan asam dalam larutan
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CH2Cl2 . mono-hydride di-anion dapat terprotonasi secara reversible dan
terdeprotonasinya oleh reaksi asam – basa menyebabkan erat kaitannya gugus
[H3−nCo15Pd9C3(CO)38]n− (n = 0 –3). Struktur Kristal dari tiga anionic dan gugus netral telah
ditentukan,H 3Co15Pd9C3(CO)38·2thf,[NEt 4][H2Co15Pd9C3(CO)38]·0.5C 6H14,[NMe 3(CH2Ph)] 2[H
Co15Pd9C3(CO)38]·C6H14 dan [NEt 4]3[Co15Pd9C3(CO)38] . Mereka tersusun dari inti stabil
Pd9(μ3-CO)2 oleh tiga fragmen organometalik Co 5C(CO)12 . Polihidrid alam dari gugus
gugus ini tidak langsung disimpulkan melalui kimia , elektrokimia dan pengukuran
magnetic. Disamping itu voltametri siklik menunjukkan bahwa anion anion
[H3−nCo15Pd9C3(CO)38]n− (n = 1 –3) adalah multivalent, sejak mereka menjalani dua atau
tiga oksidasi reversible. Pengukuran – pengukuran SQUID dari [HCo 15Pd9C3(CO)38]2
mengindikasikan bahwa gugus electron ini adalah paramagnetic dengan dua electron
tidank berpasangan, memberikan dukungan lebih lanjut untuk hidrid alamnya. Terakhir,
mempelajari struktur menunjukkan bahwa inti Pd 9 dari [H 3−nCo15Pd9C3(CO)38]n− (n = 0,1)
adalah segidelapan, yang menjadi prisma segitiga lebih mengisi anion – anion
[H3−nCo15Pd9C3(CO)38]n− (n = 2,3). Seperti penataan ulang struktur yang signifikan inti
logam dari gugus karbonil yang besar pada reaksi protonasi – deprotonasi adalah belum
pernah terjadi sebelumnya dalam gugus kimia, dan menunjukkan bahwa hidrida
interstitial mungkin memiliki efek stereokimia relevan bahkan dalam gugus – guguskarbonil yang besar.
3. Chemical Communications
Impact factor : 6378 100 issues per year
Paper : Zinc-mediated addition of diethyl bromomalonate to alkynes for the cascade
reaction towards polysubstituted pyranones and tetracarbonyl derivatives
Anne Miersch, a Klaus Harms a and Gerhard Hilt *a
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Abstract :
The zinc-mediated regioselective addition reactions of diethyl bromomalonate and
aromatic and aliphatic alkynes were investigated for the synthesis of vinyl malonates.
When the vinyl organo-zinc intermediates were reacted with acid chlorides 2 H-pyran-2-
ones were obtained while the application of oxalyl chloride and an amine led to
tetracarbonyl derivatives in a one-pot multi-step reaction sequence.
Isi :
Dalam jurnal ini menjelaskan tentang reaksi selain regioselective seng-dimediasi dietilbromomalonate dan alkuna aromatik dan alifatik juga digunakan untuk sintesis vinil
malonat. Ketika vinyl organo-seng intermediet direaksikan dengan asam klorida 2H-
pyran-2- yang diperoleh dari penerapan oksalil klorida dan amina yang menyebabkan
turunannya tetracarbonyl dalam urutan reaksi multi-langkah satu-pot.
4. Faraday Discussions
Impact factor : 3821
Paper : Corresponding states for mesostructure and dynamics of supercooled water
8/13/2019 Jurnal RSC
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David T. Limmer a and David Chandler* a
Abstract :
Water famously expands upon freezing, foreshadowed by a negative coefficient of
expansion of the liquid at temperatures close to its freezing temperature. These
behaviors, and many others, reflect the energetic preference for local tetrahedral
arrangements of water molecules and entropic effects that oppose it. Here, we provide
theoretical analysis of mesoscopic implications of this competition, both equilibrium and
non-equilibrium, including mediation by interfaces. With general scaling arguments
bolstered by simulation results, and with reduced units that elucidate correspondingstates, we derive a phase diagram for bulk and confined water and water-like materials.
For water itself, the corresponding states cover the temperature range of 150 K to 300 K
and the pressure range of 1 bar to 2 kbar. In this regime, there are two reversible
condensed phases – ice and liquid. Out of equilibrium, there is irreversible
polyamorphism, i.e. , more than one glass phase, reflecting dynamical arrest of
coarsening ice. Temperature –time plots are derived to characterize time scales of the
different phases and explain contrasting dynamical behaviors of different water-like
systems.
Translated :
Jurnal ini membahas mengenai air sebagai Air yang dikenal atas perluasan titik bekunya,
meramalkan dengan koefisien negatif ekspansi cairan pada suhu mendekati suhu beku . Perilaku
ini dan lainnya yang dimiliki air , mencerminkan preferensi energik untuk pengaturan tetrahedral
dari molekul air dan efek entropis yang menentangnya . Dengan argumen skala umum didukungoleh hasil simulasi , dan dengan unit berkurang yang menjelaskan negara-negara yang sesuai ,
kita memperoleh suatu diagram fase untuk curah dan air terbatas dan bahan-bahan seperti air .
Untuk air sendiri , bentuk-bentuk yang sesuai mencakup rentang pada suhu 150 K sampai 300 K
dan berbagai tekanan 1 bar sampai 2 kbar . sehingga dalam air memiliki dua fase terkondensasi
reversibel - es dan cair. Keluar dari keseimbangan , ada polyamorphism ireversibel , yaitu , lebih
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dari satu fase gelas , mencerminkan dinamika penangkapan es pengkasaran . Plot suhu - waktu
diturunkan untuk mengkarakterisasi skala waktu dari fase yang berbeda dan menjelaskan
kontras perilaku dinamis dari sistem air - seperti yang berbeda .
5. Green Chemistry
Impact factor : 6828 12 issues per day
Paper : Cu(OAc)2-catalyzed remote benzylic C(sp 3) –H oxyfunctionalization for C O
formation directed by the hindered para -hydroxyl group with ambient air as the
terminal oxidant under ligand- and additive-free conditions
Jian-An Jiang, a Cheng Chen, a Jian-Gang Huang, a Hong-Wei Liu, a Song Cao a and Ya-Fei
Ji*a
Abstract :
A hindered para -hydroxyl group-directed remote benzylic C(sp 3) –H oxyfunctionalization
has been developed for the straightforward transformation of 2,6-disubstituted 4-
cresols, 4-alkylphenols, 4-hydroxybenzyl alcohols and 4-hydroxybenzyl alkyl ethers into
various aromatic carbonyl compounds. The ligand- and additive-free Cu(OAc) 2-catalyzed
atmospheric oxidation mediated by ethylene glycol unlocks a facile, atom-economical,
and environmentally benign C O formation for the functionalization of primary and
secondary benzyl groups. Due to the pharmaceutical importance of 4-
hydroxybenzaldehydes and 4-hydroxyphenones, the methodology is expected to be of
significant value for both fundamental research and practical applications.
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Isi :
Menjelaskan tentang , yang menghambat para- gugus hidroksil diarahkan menjauhi
benzilik C ( sp3 ) - H oxyfunctionalization telah dikembangkan untuk transformasi
langsung dari 2,6- disubstitusi 4 - kresol , 4 - alkilfenol , alkohol 4 - hydroxybenzyl dan
eter alkil 4 - hydroxybenzyl ke dalam berbagai senyawa karbonil aromatik . Ligan - dan
aditif bebas Cu ( OAc ) oksidasi atmosfer 2 -katalis dimediasi oleh etilena glikol membuka
sebuah lancar , atom - ekonomis , dan ramah lingkungan pembentukan CO untuk
fungsionalisasi kelompok benzil primer dan sekunder . Karena pentingnya farmasi dari 4
- hydroxybenzaldehydes dan 4 - hydroxyphenones , metodologi ini diharapkan menjadi
nilai yang signifikan bagi penelitian fundamental dan aplikasi praktis.
6. Integrative Biology
Impact factor: 4321 12 issues per year
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Paper : Local control of hepatic phenotype with growth factor-encoded surfaces
Dipali Patel, a Amranul Haque, a Caroline N. Jones, a Nazgul Tuleouva, a Elena
Foster, a Tam Vu, a A. Hari Reddi b and Alexander Revzin *a
Abstract :
The goal of the present study was to modulate the phenotype expression of
hepatocytes in vitro on surfaces imprinted with growth factors (GFs). Hepatocyte growth
factor (HGF) or transforming-growth factor- β1 (TGF-β1) were mixed with collagen (I) and
robotically printed onto standard glass s lides to create arrays of 300 μm or 500 μm
diameter spots. Primary rat hepatocytes were seeded on top of the arrays, forming
clusters corresponding in size to the underlying protein spots. The TGF- β1 spots
appeared to downregulate markers of hepatic (epithelial) phenotype while upregulating
expression of mesenchymal markers. Conversely, hepatocytes cultured on HGF spots
maintained high level of epithelial markers. When hepatocytes were seeded onto
alternating spots of HGF and TGF- β1, their phenotype was fou nd to depend on center-
to-center distance between the spots. At shorter distances cross-expression of epithelial
and mesenchymal markers was observed while at distances exceeding 1.25 mm
divergence of phenotypes, epithelial on HGF and mesenchymal on TGF- β was seen.
Overall, our results demonstrate that GF-encoded surfaces can modulate phenotype
within groups of cells cultured on the same surface. Given the importance of phenotype
switching in development, fibrosis and cancer, this platform may be used to gain useful
insights into the mechanisms of processes such as epithelial-to-mesenchymal transition
or stem cell fate selections.
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7. Lab on a Chip
Impact factor :5697 24 issues per day
Paper : Biosensor design based on Marangoni flow in an evaporating drop
Joshua R. Trantum, a Mark L. Baglia, a Zachary E. Eagleton, a Raymond L.
Mernaugh b and Frederick R. Haselton *a
Abstract :
Effective point-of-care diagnostics require a biomarker detection strategy that is low-cost
and simple-to-use while achieving a clinically relevant limit of detection. Here we report
a biosensor that uses secondary flows arising from surface Marangoni stresses in an
evaporating drop to concentrate target-mediated particle aggregates in a visually
detectable spot. The spot size increases with increasing target concentration within the
dynamic range of the assay. The particle deposition patterns are visually detectable and
easily measured with simple optical techniques. We use optical coherence tomography
to characterize the effect of cross-sectional flow fields on the motion of particles in the
presence and absence of target (aggregated and non-aggregated particles, respectively).
We show that choice of substrate material and the presence of salts and glycerol in
solution promote the Marangoni-induced flows that are necessary to produce signal in
the proposed design. These evaporation-driven flows generate signal in the assay on a
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PDMS substrate but not substrates with greater thermal conductivity like indium tin
oxide-coated glass. In this proof-of-concept design we use the M13K07 bacteriophage as
a model target and 1 μm -diameter particles surface functionalized with anti-M13
monoclonal antibodies. Using standard microscopy-based techniques to measure the
final spot size, the assay has a calculated limit-of-detection of approximately 100 fM.
Approximately 80% of the maximum signal is generated within 10 minutes of depositing
a 1 μL drop of reacted sample on PDMS enabling a relatively quick time -to-result.
Isi :
Menjelaskan tentang titik efektif dalam perawatan diagnostik itu memerlukan strategi
deteksi biomarker yang murah dan sederhana, digunakan sementara mencapai batas
klinis yang relevan mendeteksi. Dengan melaporkan biosensor yang menggunakan arus
sekunder yang timbul dari permukaan Marangoni menekankan pada penurunan
penguapan untuk berkonsentrasi pada sasaran, dimediasi keseluruhan partikel di tempat
visual terdeteksi. Ukuran tempat akan meningkat dengan meningkatnya konsentrasi
target dalam jangkauan dinamis dari pengujian tersebut. Pola pengendapan partikel
secara visual terdeteksi dan mudah diukur dengan teknik optik sederhana.
Menggunakan tomografi koherensi optik untuk mengkarakterisasi efek lintas medan
aliran sectional pada gerakan partikel yang dihadapan dan tidak adanya target (agregat
dan non-agregat partikel, masing-masing). Menunjukkan bahwa pilihan bahan substrat
dan adanya garam dan gliserol dalam larutan mempromosikan arus Marangoni yang
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diinduksi diperlukan untuk menghasilkan sinyal dalam desain yang diusulkan. Pilihan
bahan substrat dan adanya garam dan gliserol dalam larutan mempromosikan
Marangoni - arus induksi yang diperlukan untuk menghasilkan sinyal dalam desain yang
diusulkan. Dalam bukti, konsep desainnya menggunakan bakteriofag M13K07 sebagai
target Model dan 1 partikel pM diameter permukaan difungsikan dengan anti - M13
antibodi monoklonal. Menggunakan teknik berbasis mikroskop standar untuk mengukur
ukuran tempat terakhir, assay memiliki batas dalam deteksi dihitung sekitar 100 FM.
Sekitar 80 % dari sinyal maksimum yang dihasilkan dalam waktu 10 menit menyetorkan
penurunan 1 uL sampel bereaksi pada PDMS memungkinkan waktu yg dihasilkan relatif
cepat .
8. Materials Horizons
Impact factor : 6 issues per year
Review article : Taking orders from light: progress in photochromic bio-materials
Junji Zhang, a Jiaxing Wang a and He Tian *a
Abtract :
Photochromic materials are a family of compounds which undergo photo-reversible
transformations between two different isomers with distinct physical and chemical
properties. Most smart photochromic materials have been exploited in research areas
such as electro-optical functional materials, while recently their applications have
extended to novel bio-materials. Biological systems, such as tissue/cellular imaging,
nucleotides, peptides, ion channels, etc. , have emerged as a revolutionary research
frontier for photochromic materials since both covalent coupling and non-covalent
interactions with bio-molecules have been achieved. This review commences with a
brief description of exciting progress in this field, and describes strategies for using
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Impact factor : 6233 24 issues per year
Paper : Bio-inspired formation of functional calcite/metal oxide nanoparticle composites
Yi-Yeoun Kim,*a Anna S. Schenk, a Dominic Walsh, b Alexander N. Kulak, a Oscar
Cespedes c and Fiona C. Meldrum* a
Abstract :
Biominerals are invariably composite materials, where occlusion of organic
macromolecules within single crystals can significantly modify their properties. In this
article, we take inspiration from this biogenic strategy to generate composite crystals inwhich magnetite (Fe 3O4) and zincite (ZnO) nanoparticles are embedded within a calcite
single crystal host, thereby endowing it with new magnetic or optical properties. While
growth of crystals in the presence of small molecules, macromolecules and particles can
lead to their occlusion within the crystal host, this approach requires particles with
specific surface chemistries. Overcoming this limitation, we here precipitate crystals
within a nanoparticle-functionalised xyloglucan gel, where gels can also be incorporated
within single crystals, according to their rigidity. This method is independent of the
nanoparticle surface chemistry and as the gel maintains its overall structure when
occluded within the crystal, the nanoparticles are maintained throughout the crystal,
preventing, for example, their movement and accumulation at the crystal surface during
crystal growth. This methodology is expected to be quite general, and could be used to
endow a wide range of crystals with new functionalities.
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Isi :
Biominerals adalah bahan yang selalu komposit, dimana oklusi makromolekul organik
dalam kristal tunggal secara signifikan dapat memodifikasi sifat-sifatnya. Pada artikel ini,
diambil inspirasi dari strategi biogenik untuk menghasilkan kristal komposit dimana
magnetit ( Fe3O4 ) dan zincite ( ZnO ) nanopartikel yang tertanam dalam kalsit tunggal
tuan kristal, sehingga endowing dengan sifat magnetik atau optik baru. Sementara
pertumbuhan kristal di hadapan molekul kecil, makromolekul dan partikel dapat
menyebabkan oklusinya dalam sejumlah besar kristal, pendekatan ini membutuhkan
partikel dengan permukaan kimia spesifik. Mengatasi keterbatasan ini, dengan
mengendapkan kristal dalam gel xyloglucan nanopartikel - functionalised , dimana gel
juga dapat dimasukkan dalam kristal tunggal, menurut kekakuannya. Metode ini tidak
tergantung pada permukaan kimia nanopartikel dan sebagai gel mempertahankan
struktur secara keseluruhan ketika tersumbat dalam kristal, nanopartikel
diselenggarakan diseluruh kristal, mencegah, misalnya gerakan dan akumulasi pada
permukaan kristal selama pertumbuhan kristal. Metodologi ini diharapkan menjadi
cukup umum, dan dapat digunakan untuk memberkati berbagai kristal dengan
fungsionalitas baru.
10. Nanoscale
Impact factor : 6233 24 issues per year
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Paper : Programmed assembly of polymer –DNA conjugate nanoparticles with optical
readout and sequence-specific activation of biorecognition.
Abstract :
Soft micellar nanoparticles can be prepared from DNA conjugates designed to
assemble via base pairing such that strands containing a polymer corona and a
cholesterol tail generate controlled supramolecular architecture. Functionalization of
one DNA conjugate strand with a biorecognition ligand results in shielding of the ligand
when in the micelle, while encoding of the DNA sequences with overhangs allows
supramolecular unpacking by addition of a complementary strand and sequence-specific
unshielding of the ligand. The molecular assembly/disassembly and ‘on–off’ switch of
the recognition signal is visualized by FRET pair signalling, PAGE and a facile turbidimetric
binding assay, allowing direct and amplified readout of nucleic acid sequence
recognition.
Isi :
Menjelaskan tentan perakitan diprogram konjugasi polimer nanopartikel-DNA denganpembacaan optik dan aktivasi-urutan tertentu dari biorecognition, yang dibuat dari
konjugasi DNA yang dirancang hanya untuk meyerupai, melalui perpasangan basa
sehingga untai mengandung korona polimer dan ekor kolesterol dan menghasilkan
arsitektur supramolekul. Fungsi dari satu DNA untai konjugat dengan hasil biorecognition
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ligan dilihat dalam perisai ligan ketika di misel, sedangkan pengkodean urutan DNA
memungkinkan supramolekul membuka dengan penambahan untai komplementer dan
unshielding-urutan spesifik ligan. Molekul perakitan / pembukaan 'on-off' ini beralih dari
sinyal pengakuan oleh pasangan fret sinyal, PAGE dan uji turbidimetri, yang
memungkinkan pembacaan langsung dan juga diperkuat pengakuan urutan asam
nukleat. Biorecognition disini adalah ikatan2 dalam protein Tersusun dari ikatan
nonkovalen seperti ikatan ion Selain itu tersusun oleh ikatan hidrogen, ikatan hidrofobik
(Mempelajari aspek interaksi antara protein-protein, protein-ligan, proten-DNA).