Judith HsiaJudith Hsiajhsia@mfa.gwu.edujhsia@mfa.gwu.edu

202-741-2321202-741-2321

Hormone Therapy Trial: Coronary Heart Disease & Fractures.Adverse effect for Breast Cancer?

Calcium/Vitamin D Trial: Fractures & Colorectal Cancer

Dietary Modification Trial:Breast & Colorectal Cancers & Coronary Heart Disease

93,676

Observational Study

48,835

36,282

3 C

on

trolled

Tri

als

1 O

bserv

ati

on

al

Stu

dy

27,347

161,808 women total

Women’s Health Initiative

CV risk with PreHTNCV risk with PreHTNNormal Prehypertension Hypertension

N(Ann %) HR

N (Ann %) HR (95% CI)

N (Ann %) HR (95% CI)

CVdeath 83(0.07)

1219

(0.12)1.58 (1.12, 2.21)

510 (0.32)

3.02 (2.18, 4.18)

MI 177 (0.14)

1442

(0.24)1.76 (1.40, 2.22)

770 (0.48)

2.86 (2.28, 3.59)

Stroke 137 (0.11)

1407

(0.22)1.93 (1.49, 2.50)

778 (0.49)

3.62 (2.82, 4.66)

CHF 137 (0.11)

1351

(0.19)1.36 (1.05, 1.77)

848 (0.53)

2.78 (2.17, 3.57)

Any CV event

442 (0.35)

11196 (0.66)

1.66 (1.44, 1.92)2253

(1.41)2.89 (2.52, 3.32)

Stratified by age and trial participation; adj for age, BMI, DM, high chol and smoking

Other studiesOther studies ““Pilot study to identify novel Pilot study to identify novel

biomarkers of myocardial necrosis”biomarkers of myocardial necrosis” American Red Cross; David Hammond, PIAmerican Red Cross; David Hammond, PI

Selenium and Vitamin E Selenium and Vitamin E Chemoprevention Trial (SELECT) Chemoprevention Trial (SELECT) NCI via subcontract with SWOGNCI via subcontract with SWOG

Phase III Randomized Study of Phase III Randomized Study of Exemestane Versus Placebo in Exemestane Versus Placebo in Postmenopausal Women at Increased Postmenopausal Women at Increased Risk of Developing Breast CancerRisk of Developing Breast Cancer National Cancer Institute of Cancer National Cancer Institute of Cancer