JOURNAL OF IMMUNOLOGY VOL. 172, NO. 1, JANUARY 1
Transcript of JOURNAL OF IMMUNOLOGY VOL. 172, NO. 1, JANUARY 1
JOURNAL OF IMMUNOLOGY VOL. 172, NO. 1, JANUARY 1; 2004
IN THIS ISSUE 1-2LETTERS TO THE EDITOR Dendritic Cell Differentiation Antonio Curti, Elisa Ferri, Simona Pandolfi, Alessandro Isidori, Roberto M. Lemoli, Marc Dauer, Katharina Schad, Jan Herten, Stefan Endres, and Andreas Eigler
3-4
Signaling and Cell Surface Expression of µH Chains in the Absence of Light Chains Daniel Corcos, Hans-Martin Jäck, Wolfgang Schuh, Silke Meister, and Edith Roth
4-5
BRIEF REVIEWS Regulation of Leukocyte Transmigration: Cell Surface Interactions and Signaling Events Yuan Liu, Sunil K. Shaw, Shuo Ma, Lin Yang, Francis W. Luscinskas, and Charles A. Parkos
7-13
CUTTING EDGE Cutting Edge: IL-7-Dependent Homeostatic Proliferation of CD8+ T Cells in Neonatal Mice Allows the Generation of Long-Lived Natural Memory T Cells Thomas Schüler, Günter J. Hämmerling, and Bernd Arnold
15-19
Cutting Edge: An Endogenous Pathway to Systemic Inflammatory Response Syndrome (SIRS)-Like Reactions through Toll-Like Receptor 4 Geoffrey B. Johnson, Gregory J. Brunn, and Jeffrey L. Platt
20-24
CELLULAR IMMUNOLOGY AND IMMUNE REGULATION Expression of Preproinsulin-2 Gene Shapes the Immune Response to Preproinsulin in Normal Mice Béatrice Faideau, Jean-Paul Briand, Chantal Lotton, Isabelle Tardivel, Philippe Halbout, Jacques Jami, John F. Elliott, Patricia Krief, Sylviane Muller, Christian Boitard, and Jean-Claude Carel
25-33
B7 Expression on T Cells Down-Regulates Immune Responses through CTLA-4 Ligation via R-T Interactions Patricia A. Taylor, Christopher J. Lees, Sylvie Fournier, James P. Allison, Arlene H. Sharpe, and Bruce R. Blazar
34-39
A Role for TCR Affinity in Regulating Naive T Cell Homeostasis William C. Kieper, J. Theodore Burghardt, and Charles D. Surh
40-44
Essential Role for Neutrophil Recruitment to the Liver in Concanavalin A-Induced Hepatitis Claudine S. Bonder, Maureen N. Ajuebor, Lori D. Zbytnuik, Paul Kubes, and Mark G. Swain
45-53
Sensing Environmental Lipids by Dendritic Cell Modulates Its Function Frédéric Coutant, Sophie Agaugué, Laure Perrin-Cocon, Patrice André, and Vincent Lotteau
54-60
Sustained IL-12 Signaling Is Required for Th1 Development Veronica Athie-Morales, Hermelijn H. Smits, Doreen A. Cantrell, and Catharien M. U. Hilkens
61-69
A CD91-Positive Subset of CD11c+ Blood Dendritic Cells: 70-78
Characterization of the APC that Functions to Enhance Adaptive Immune Responses against CD91-Targeted Antigens Justin P. Hart, Michael D. Gunn, and Salvatore V. Pizzo Rosmarinic Acid Induces p56lck-Dependent Apoptosis in Jurkat and Peripheral T Cells via Mitochondrial Pathway Independent from Fas/Fas Ligand Interaction Yun-Gyoung Hur, Yungdae Yun, and Jonghwa Won
79-87
The IL-12 Signature: NK Cell Terminal CD56+high Stage and Effector Functions Matthew J. Loza and Bice Perussia
88-96
The Susceptibility to Experimental Myasthenia Gravis of STAT6-/- and STAT4-/- BALB/c Mice Suggests a Pathogenic Role of Th1 Cells Wei Wang, Norma S. Ostlie, Bianca M. Conti-Fine, and Monica Milani
97-103
Activation of Resting Human Primary T Cells with Chimeric Receptors: Costimulation from CD28, Inducible Costimulator, CD134, and CD137 in Series with Signals from the TCR Chain Helene M. Finney, Arne N. Akbar, and Alastair D. G. Lawson
104-113
Up-Regulation of Hlx in Immature Th Cells Induces IFN- Expression Wei-ping Zheng, Qian Zhao, Xinyan Zhao, Baiyong Li, Mike Hubank, David G. Schatz, and Richard A. Flavell
114-122
NK Cell TRAIL Eliminates Immature Dendritic Cells In Vivo and Limits Dendritic Cell Vaccination Efficacy Yoshihiro Hayakawa, Valentina Screpanti, Hideo Yagita, Alf Grandien, Hans-Gustaf Ljunggren, Mark J. Smyth, and Benedict J. Chambers
123-129
NK Cells Regulate CD8+ T Cell Effector Function in Response to an Intracellular Pathogen Ramakrishna Vankayalapati, Peter Klucar, Benjamin Wizel, Stephen E. Weis, Buka Samten, Hassan Safi, Homayoun Shams, and Peter F. Barnes
130-137
APC-Independent Activation of NK Cells by the Toll-Like Receptor 3 Agonist Double-Stranded RNA Kerstin N. Schmidt, Beatrice Leung, Mandy Kwong, Kol A. Zarember, Sanjeev Satyal, Tony A. Navas, Fay Wang, and Paul J. Godowski
138-143
Analysis of Gene Expression and Ig Transcription in PU.1/Spi-B-Deficient Progenitor B Cell Lines Brock L. Schweitzer and Rodney P. DeKoter
144-154
Fully Functional HLA B27-Restricted CD4+ as well as CD8+ T Cell Responses in TCR Transgenic Mice Matthew Roddis, Robert W. Carter, Mei-Yi Sun, Thomas Weissensteiner, Andrew J. McMichael, Paul Bowness, and Helen C. Bodmer
155-161
Melanoma-Reactive Class I-Restricted Cytotoxic T Cell Clones Are Stimulated by Dendritic Cells Loaded with Synthetic Peptides, but Fail to Respond to Dendritic Cells Pulsed with Melanoma-Derived Heat Shock Proteins In Vitro Kristina Fleischer, Burkhard Schmidt, Wolfgang Kastenmüller, Dirk H. Busch, Ingo Drexler, Gerd Sutter, Michael Heike, Christian Peschel, and Helga Bernhard
162-169
A Repressor of GATA-Mediated Negative Feedback Mechanism of T Cell Activation
170-177
Shi-Chuen Miaw, Bok Yun Kang, Ian Alexander White, and I-Cheng Ho Tolerogenic APC Generate CD8+ T Regulatory Cells That Modulate Pulmonary Interstitial Fibrosis Jie Zhang-Hoover and Joan Stein-Streilein
178-185
CD1-Dependent Regulation of Chronic Central Nervous System Inflammation in Experimental Autoimmune Encephalomyelitis Anna Teige, Ingrid Teige, Shahram Lavasani, Robert Bockermann, Emma Mondoc, Rikard Holmdahl, and Shohreh Issazadeh-Navikas
186-194
Cognate B Cell Signaling via MHC Class II: Differential Regulation of B Cell Antigen Receptor and MHC Class II/Ig- Signaling by CD22 David M. Mills, John C. Stolpa, and John C. Cambier
195-201
Inducible Heat Shock Protein 70 Promotes Myelin Autoantigen Presentation by the HLA Class II Marcin P. Mycko, Hanna Cwiklinska, Jacek Szymanski, Bozena Szymanska, Grzegorz Kudla, Lukasz Kilianek, Artur Odyniec, Celia F. Brosnan, and Krzysztof W. Selmaj
202-213
Regulation of CD103 Expression by CD8+ T Cells Responding to Renal Allografts Donghua Wang, Rongwen Yuan, Ye Feng, Riham El-Asady, Donna L. Farber, Ronald E. Gress, Philip J. Lucas, and Gregg A. Hadley
214-221
Superantigen Stimulation Reveals the Contribution of Lck to Negative Regulation of T Cell Activation Gabriel Criado and Joaquín Madrenas
222-230
Role of TNF Receptor-Associated Factor 3 in the CD40 Signaling by Production of Reactive Oxygen Species through Association with p40phox, a Cytosolic Subunit of Nicotinamide Adenine Dinucleotide Phosphate Oxidase Yun Jung Ha and Jong Ran Lee
231-239
Effects of T Cell Frequency and Graft Size on Transplant Outcome in Mice Chunshui He, Soren Schenk, Qiwei Zhang, Anna Valujskikh, Jörg Bayer, Robert L. Fairchild, and Peter S. Heeger
240-247
T Cell Clonal Conditioning: A Phase Occurring Early after Antigen Presentation but before Clonal Expansion Is Impacted by Toll-Like Receptor Stimulation Joseph R. Maxwell, Robert J. Rossi, Stephen J. McSorley, and Anthony T. Vella
248-259
Human Intestinal Fibroblasts Prevent Apoptosis in Human Intestinal Mast Cells by a Mechanism Independent of Stem Cell Factor, IL-3, IL-4, and Nerve Growth Factor Gernot Sellge, Axel Lorentz, Thomas Gebhardt, Francesca Levi-Schaffer, Hueseyin Bektas, Michael P. Manns, Detlef Schuppan, and Stephan C. Bischoff
260-267
CXCR1+CD4+ T Cells in Human Allergic Disease James N. Francis, Mikila R. Jacobson, Clare M. Lloyd, Ian Sabroe, Stephen R. Durham, and Stephen J. Till
268-273
Colorectal Cancer Cells Induce Lymphocyte Apoptosis by an Endothelial Monocyte-Activating Polypeptide-II-Dependent Mechanism J. Clifford Murray, Peter Symonds, Wynne Ward, Mary Huggins, Anna
274-281
Tiga, Katherine Rice, Yee M. Heng, Ian Todd, and R. Adrian Robins The 11 and E7 Integrins Define a Subset of Dendritic Cells in Peripheral Lymph Nodes with Unique Adhesive and Antigen Uptake Properties Jonathan T. Pribila, Andrea A. Itano, Kristen L. Mueller, and Yoji Shimizu
282-291
Dendritic Cell Maturation Controls Adhesion, Synapse Formation, and the Duration of the Interactions with Naive T Lymphocytes Federica Benvenuti, Cecile Lagaudrière-Gesbert, Isabelle Grandjean, Carolina Jancic, Claire Hivroz, Alain Trautmann, Olivier Lantz, and Sebastian Amigorena
292-301
Dermal Enhancement: Bacterial Products on Intact Skin Induce and Augment Organ-Specific Autoimmune Disease D. Sean Riminton, Rama Kandasamy, Danijela Dravec, Antony Basten, and Alan G. Baxter
302-309
Pulmonary Tumors Inefficiently Prime Tumor-Specific T Cells Leigh A. O’Mara and Paul M. Allen
310-317
MOLECULAR AND STRUCTURAL IMMUNOLOGY Dexamethasone Inhibits IL-12p40 Production in Lipopolysaccharide-Stimulated Human Monocytic Cells by Down-Regulating the Activity of c-Jun N-Terminal Kinase, the Activation Protein-1, and NF-B Transcription Factors Wei Ma, Katrina Gee, Wilfred Lim, Kelly Chambers, Jonathan B. Angel, Maya Kozlowski, and Ashok Kumar
318-330
Two Distinct Waves of Membrane-Proximal B Cell Antigen Receptor Signaling Differentially Regulated by Src Homology 2-Containing Inositol Polyphosphate 5-Phosphatase Allyson K. Krahn, Kewei Ma, Sen Hou, Vincent Duronio, and Aaron J. Marshall
331-339
Partitioning of Rearranged Ig Genes by Mutation Analysis Demonstrates D-D Fusion and V Gene Replacement in the Expressed Human Repertoire Andrew M. Collins, Masashi Ikutani, Daniela Puiu, Gregory A. Buck, Aradhita Nadkarni, and Bruno Gaeta
340-348
A Functional C5a Anaphylatoxin Receptor in a Teleost Species M. Claire H. Holland and John D. Lambris
349-355
Domain Shuffling Has Been the Main Mechanism Forming New Hominoid Killer Cell Ig-Like Receptors Raja Rajalingam, Peter Parham, and Laurent Abi-Rached
356-369
The Tetraspanin CD81 Is Necessary for Partitioning of Coligated CD19/CD21-B Cell Antigen Receptor Complexes into Signaling-Active Lipid Rafts Anu Cherukuri, Tsipi Shoham, Hae Won Sohn, Shoshana Levy, Stephen Brooks, Robert Carter, and Susan K. Pierce
370-380
Molecular Characterization of a Putative Antiretroviral Transcriptional Factor, OTK18 Kimberly A. Carlson, Gary Leisman, Jenae Limoges, Garrett D. Pohlman, Masahide Horiba, James Buescher, Howard E. Gendelman, and Tsuneya Ikezu
381-391
DEFENSE Herpes Simplex Virus-Specific CD8+ T Cells Can Clear Established 392-397
Lytic Infections from Skin and Nerves and Can Partially Limit the Early Spread of Virus after Cutaneous Inoculation Allison van Lint, Margaret Ayers, Andrew G. Brooks, Richard M. Coles, William R. Heath, and Francis R. Carbone Essential Contribution of Monocyte Chemoattractant Protein-1/C-C Chemokine Ligand-2 to Resolution and Repair Processes in Acute Bacterial Pneumonia Hideaki Amano, Kounosuke Morimoto, Masachika Senba, Hui Wang, Yuko Ishida, Atsushi Kumatori, Hiroyuki Yoshimine, Kazunori Oishi, Naofumi Mukaida, and Tsuyoshi Nagatake
398-409
Actinobacillus actinomycetemcomitans Cytolethal Distending Toxin (Cdt): Evidence That the Holotoxin Is Composed of Three Subunits: CdtA, CdtB, and CdtC Bruce J. Shenker, Dave Besack, Terry McKay, Lisa Pankoski, Ali Zekavat, and Donald R. Demuth
410-417
Localization of Cystic Fibrosis Transmembrane Conductance Regulator to Lipid Rafts of Epithelial Cells Is Required for Pseudomonas aeruginosa-Induced Cellular Activation Michael P. Kowalski and Gerald B. Pier
418-425
Organism-Specific Neutrophil-Endothelial Cell Interactions in Response to Escherichia coli, Streptococcus pneumoniae, and Staphylococcus aureus Jessica G. Moreland, Gail Bailey, William M. Nauseef, and Jerrold P. Weiss
426-432
Critical Role of T Cell-Dependent Serum Antibody, but Not the Gut-Associated Lymphoid Tissue, for Surviving Acute Mucosal Infection with Citrobacter rodentium, an Attaching and Effacing Pathogen Lynn Bry and Michael B. Brenner
433-441
Redox-Sensing Release of Human Thioredoxin from T Lymphocytes with Negative Feedback Loops Norihiko Kondo, Yasuyuki Ishii, Yong-Won Kwon, Masaki Tanito, Hiroyuki Horita, Yumiko Nishinaka, Hajime Nakamura, and Junji Yodoi
442-448
Modulation of the Phosphoinositide 3-Kinase Pathway Alters Innate Resistance to Polymicrobial Sepsis David L. Williams, Chuanfu Li, Tuanzhu Ha, Tammy Ozment-Skelton, John H. Kalbfleisch, Johanna Preiszner, Lynne Brooks, Kevin Breuel, and John B. Schweitzer
449-456
STAT1 Plays a Critical Role in the Regulation of Antimicrobial Effector Mechanisms, but Not in the Development of Th1-Type Responses during Toxoplasmosis Linda A. Lieberman, Monica Banica, Steven L. Reiner, and Christopher A. Hunter
457-463
Hyperactivation of STAT3 Is Involved in Abnormal Differentiation of Dendritic Cells in Cancer Yulia Nefedova, Mei Huang, Sergei Kusmartsev, Raka Bhattacharya, Pingyan Cheng, Raoul Salup, Richard Jove, and Dmitry Gabrilovich
464-474
Dendritic Cells from Malaria-Infected Mice Are Fully Functional APC James A. Perry, Adam Rush, Randy J. Wilson, Christine S. Olver, and Anne C. Avery
475-482
Conserved Hierarchy of Helper T Cell Responses in a Chimpanzee during Primary and Secondary Hepatitis C Virus Infections Naglaa H. Shoukry, John Sidney, Alessandro Sette, and Christopher M. Walker
483-492
Galectin-3 Mediates IL-4-Induced Survival and Differentiation of B Cells: Functional Cross-Talk and Implications during Trypanosoma cruzi Infection Eva V. Acosta-Rodríguez, Carolina L. Montes, Claudia C. Motrán, Elina I. Zuniga, Fu-Tong Liu, Gabriel A. Rabinovich, and Adriana Gruppi
493-502
Improved Effector Activity and Memory CD8 T Cell Development by IL-2 Expression during Experimental Respiratory Syncytial Virus Infection Jun Chang, So Young Choi, Hyun Tak Jin, Young Chul Sung, and Thomas J. Braciale
503-508
Neutrophil Serine Proteinases Cleave Bacterial Flagellin, Abrogating Its Host Response-Inducing Activity Yolanda S. López-Boado, Marcia Espinola, Scott Bahr, and Abderrazzaq Belaaouaj
509-515
Murine -Herpesvirus-68-Induced IL-12 Contributes to the Control of Latent Viral Burden, but Also Contributes to Viral-Mediated Leukocytosis Sherine F. Elsawa and Kenneth L. Bost
516-524
IL-23 Induces Stronger Sustained CTL and Th1 Immune Responses Than IL-12 in Hepatitis C Virus Envelope Protein 2 DNA Immunization Sang-Jun Ha, Doo-Jin Kim, Kwan-Hyuck Baek, Yung-Dae Yun, and Young-Chul Sung
525-531
Differential Regulation of IgG Anti-Capsular Polysaccharide and Antiprotein Responses to Intact Streptococcus pneumoniae in the Presence of Cognate CD4+ T Cell Help Abdul Q. Khan, Andrew Lees, and Clifford M. Snapper
532-539
INFLAMMATION Proteolytic Regulation of the Urokinase Receptor/CD87 on Monocytic Cells by Neutrophil Elastase and Cathepsin G Nathalie Beaufort, Dominique Leduc, Jean-Claude Rousselle, Viktor Magdolen, Thomas Luther, Abdelkader Namane, Michel Chignard, and Dominique Pidard
540-549
IFN-Inducible Protein 10/CXC Chemokine Ligand 10-Independent Induction of Experimental Autoimmune Encephalomyelitis Robyn S. Klein, Leonid Izikson, Terry Means, Hilary D. Gibson, Eugene Lin, Raymond A. Sobel, Howard L. Weiner, and Andrew D. Luster
550-559
Intracellular Regulation of Fas-Induced Apoptosis in Human Fibroblasts by Extracellular Factors and Cycloheximide Begoña Santiago, María Galindo, Guillermo Palao, and José L. Pablos
560-566
Signal Transducer and Activator of Transcription 3 Is the Dominant Mediator of the Anti-Inflammatory Effects of IL-10 in Human Macrophages Lynn Williams, Laura Bradley, Alexandra Smith, and Brian Foxwell
567-576
Membrane-Associated IL-1 Contributes to Chronic Synovitis and 577-584
Cartilage Destruction in Human IL-1 Transgenic Mice Yasuo Niki, Harumoto Yamada, Toshiyuki Kikuchi, Yoshiaki Toyama, Hideo Matsumoto, Kyosuke Fujikawa, and Norihiro Tada Soluble Fractalkine Prevents Monocyte Chemoattractant Protein-1-Induced Monocyte Migration via Inhibition of Stress-Activated Protein Kinase 2/p38 and Matrix Metalloproteinase Activities Sébastien Vitale, Annie Schmid-Alliana, Véronique Breuil, Manuel Pomeranz, Marie-Ange Millet, Bernard Rossi, and Heidy Schmid-Antomarchi
585-592
Neutralizing Endogenous IL-6 Renders Mast Cells of the MCT Type from Lung, but Not the MCTC Type from Skin and Lung, Susceptible to Human Recombinant IL-4-Induced Apoptosis Carole A. Oskeritzian, Wei Zhao, Andrea L. Pozez, Neri M. Cohen, Margaret Grimes, and Lawrence B. Schwartz
593-600
Cytoskeletal Reorganization Internalizes Multiple Transient Receptor Potential Channels and Blocks Calcium Entry into Human Neutrophils Kiyoshi Itagaki, Kolenkode B. Kannan, Brij B. Singh, and Carl J. Hauser
601-607
Intercellular Adhesion Molecule-1 Mediates Cellular Cross-Talk between Parenchymal and Immune Cells after Lipopolysaccharide Neutralization Jin-Hwa Lee, Lorenzo Del Sorbo, Stefan Uhlig, Giuliana A. Porro, Thomas Whitehead, Stefanos Voglis, Mingyao Liu, Arthur S. Slutsky, and Haibo Zhang
608-616
CLINICAL IMMUNOLOGY Corticosteroids Regulate Epithelial Cell Differentiation and Hassall Body Formation in the Human Thymus Laura P. Hale and M. Louise Markert
617-624
Impaired Clearance of Apoptotic Cells Induces the Activation of Autoreactive Anti-Sm Marginal Zone and B-1 B Cells Ye Qian, Hongsheng Wang, and Stephen H. Clarke
625-635
Gene Expression Profiling Provides Insight into the Pathophysiology of Chronic Granulomatous Disease Scott D. Kobayashi, Jovanka M. Voyich, Kevin R. Braughton, Adeline R. Whitney, William M. Nauseef, Harry L. Malech, and Frank R. DeLeo
636-643
Determinants of Antileukemia Effects of Allogeneic NK Cells Wing Leung, Rekha Iyengar, Victoria Turner, Peter Lang, Peter Bader, Paul Conn, Dietrich Niethammer, and Rupert Handgretinger
644-650
A Novel Mechanism of Alternative Promoter and Splicing Regulates the Epitope Generation of Tumor Antigen CML66-L Yan Yan, Leuyen Phan, Fan Yang, Moshe Talpaz, Yu Yang, Zeyu Xiong, Bernard Ng, Nikolai A. Timchenko, Catherine J. Wu, Jerome Ritz, Hong Wang, and Xiao-Feng Yang
651-660
Antibody Cross-Reactivity between Myelin Oligodendrocyte Glycoprotein and the Milk Protein Butyrophilin in Multiple Sclerosis Johannes Guggenmos, Anna S. Schubart, Sherry Ogg, Magnus Andersson, Tomas Olsson, Ian H. Mather, and Christopher Linington
661-668
Distortion of the Self-Reactive IgG Antibody Repertoire in Multiple Sclerosis as a New Diagnostic Tool
669-678
Didier Lefranc, Lionel Almeras, Sylvain Dubucquoi, Jérôme de Seze, Patrick Vermersch, and Lionel Prin CD4+ T Cells Mediate Murine Syngeneic Graft-versus-Host Disease-Associated Colitis J. Scott Bryson, Lining Zhang, Sarah W. Goes, C. Darrell Jennings, Betty E. Caywood, Sonia L. Carlson, and Alan M. Kaplan
679-687
NF-B p65 Antagonizes IL-4 Induction by c-maf in Minimal Change Nephrotic Syndrome Asta Valanciuté, Sabine le Gouvello, Brigitte Solhonne, André Pawlak, Philippe Grimbert, Luc Lyonnet, Sophie Hue, Philippe Lang, Philippe Remy, Rémy Salomon, Albert Bensman, Georges Guellaën, and Djillali Sahali
688-698
Thymic Selection and Peripheral Activation of CD8 T Cells by the Same Class I MHC/Peptide Complex Justine D. Mintern, Madelon M. Maurice, Hidde L. Ploegh, and Eckart Schott
699-708
A Major B Cell Epitope Present on the Apoptotic but Not the Intact Form of the U1-70-kDa Ribonucleoprotein Autoantigen Eric L. Greidinger, Mark F. Foecking, Joseph Magee, Linda Wilson, Sriya Ranatunga, Robert A. Ortmann, and Robert W. Hoffman
709-716
CORRECTIONS CD8+ and CD11b+ Dendritic Cell-Restricted MHC Class II Controls Th1 CD4+ T Cell Immunity Maria P. Lemos, Lian Fan, David Lo, and Terri M. Laufer
717
Another View of T Cell Antigen Recognition: Cooperative Engagement of Glycolipid Antigens by Va14Ja18 Natural TCR Aleksandar K. Stanic, R. Shashidharamurthy, Jelena S. Bezbradica, Naoto Matsuki, Yoshitaka Yoshimura, Sachiko Miyake, Eun Young Choi, Todd D. Schell, Luc Van Kaer, Satvir S. Tevethia, Derry C. Roopoenian, Takashi Yamamura, and Sebastian Joyce
717
Microglia-Mediated Nitric Oxide Cytotoxicity of T Cells Following Amyloid Peptide Presentation to Th1 Cells Alon Monsonego, Jaime Imitola, Victor Zota, Takatoku Oida, and Howard L. Weiner
717
Regulation of Murine Inflammatory Bowel Disease by CD25+ and CD25-CD4+ Glucocorticoid-Induced TNF Receptor Family-Related Gene Regulatory T Cells Koji Uraushihara, Takanori Kanai, Kwibeom Ko, Teruji Totsuka, Shin Makita, Ryoichi Iiyama, Tetsuya Nakamura, and Mamoru Watanabe
717
VOL. 172, NO. 2 , JANUARY 15; 2004 IN THIS ISSUE 745-746 CUTTING EDGE Cutting Edge: Anthrax Lethal Toxin Inhibits Activation of IFN-Regulatory Factor 3 by Lipopolysaccharide Oanh Dang, Lorena Navarro, Keith Anderson, and Michael David
747-751
Cutting Edge: NF-B2 Is a Negative Regulator of Dendritic Cell Function Kendra Speirs, Linda Lieberman, Jorge Caamano, Christopher A. Hunter, and Phillip Scott
752-756
Cutting Edge: Novel Priming of Tumor-Specific Immunity by NKG2D-Triggered NK Cell-Mediated Tumor Rejection and Th1-Independent CD4+ T Cell Pathway Jennifer A. Westwood, Janice M. Kelly, Jane E. Tanner, Michael H. Kershaw, Mark J. Smyth, and Yoshihiro Hayakawa
757-761
Cutting Edge: BAFF Regulates CD21/35 and CD23 Expression Independent of Its B Cell Survival Function Leonid Gorelik, Anne H. Cutler, Greg Thill, Steven D. Miklasz, Dianna E. Shea, Christine Ambrose, Sarah A. Bixler, Lihe Su, Martin L. Scott, and Susan L. Kalled
762-766
CELLULAR IMMUNOLOGY AND IMMUNE REGULATION Differential Role of CCR2 in Islet and Heart Allograft Rejection: Tissue Specificity of Chemokine/Chemokine Receptor Function In Vivo Reza Abdi, Terry K. Means, Toshiro Ito, Rex Neal Smith, Nader Najafian, Mollie Jurewicz, Vaja Tchipachvili, Israel Charo, Hugh Auchincloss, Jr., Mohamed H. Sayegh, and Andrew D. Luster
767-775
Enhanced Priming of Antigen-Specific CTLs In Vivo by Embryonic Stem Cell-Derived Dendritic Cells Expressing Chemokine Along with Antigenic Protein: Application to Antitumor Vaccination Hidetake Matsuyoshi, Satoru Senju, Shinya Hirata, Yoshihiro Yoshitake, Yasushi Uemura, and Yasuharu Nishimura
776-786
CD7 and CD28 Are Required for Murine CD4+CD25+ Regulatory T Cell Homeostasis and Prevention of Thyroiditis Gregory D. Sempowski, Scott J. Cross, Craig S. Heinly, Richard M. Scearce, and Barton F. Haynes
787-794
TCR-Independent and Caspase-Independent Apoptosis of Murine Thymocytes by CD24 Cross-Linking Kyeong Cheon Jung, Weon Seo Park, Hae Jung Kim, Eun Young Choi, Myeong-Cherl Kook, Han-Woong Lee, and Youngmee Bae
795-802
Marginal Zone, but Not Follicular B Cells, Are Potent Activators of Naive CD4 T Cells Kalaya Attanavanich and John F. Kearney
803-811
TNF Deficiency Fails to Protect BAFF Transgenic Mice against Autoimmunity and Reveals a Predisposition to B Cell Lymphoma Marcel Batten, Carrie Fletcher, Lai Guan Ng, Joanna Groom, Julie Wheway, Yacine Laâbi, Xiaoguan Xin, Pascal Schneider, Jurg Tschopp, Charles R. Mackay, and Fabienne Mackay
812-822
Progressive Surface B Cell Antigen Receptor Down-Regulation Accompanies Efficient Development of Antinuclear Antigen B Cells to Mature, Follicular Phenotype Lynn Heltemes-Harris, Xiaohe Liu, and Tim Manser
823-833
TGF-1 Plays an Important Role in the Mechanism of CD4+CD25+ Regulatory T Cell Activity in Both Humans and Mice Kazuhiko Nakamura, Atsushi Kitani, Ivan Fuss, Aasta Pedersen, Naohiko Harada, Hajime Nawata, and Warren Strober
834-842
Ephrin-A1 Suppresses Th2 Cell Activation and Provides a Regulatory Link to Lung Epithelial Cells Jan G. Wohlfahrt, Christian Karagiannidis, Steffen Kunzmann, Michelle M. Epstein, Werner Kempf, Kurt Blaser, and Carsten B. Schmidt-Weber
843-850
Central Tolerance to Self-Antigen Expressed by Cortical Epithelial 851-856
Cells Dita Mayerova and Kristin A. Hogquist Dendritic Cell Immunization Route Determines CD8+ T Cell Trafficking to Inflamed Skin: Role for Tissue Microenvironment and Dendritic Cells in Establishment of T Cell-Homing Subsets Jan C. Dudda, Jan C. Simon, and Stefan Martin
857-863
Turnover and Proliferation of NK Cells in Steady State and Lymphopenic Conditions Amanda M. Jamieson, Patricia Isnard, Jeffrey R. Dorfman, Mark C. Coles, and David H. Raulet
864-870
MHC Class II Molecules Play a Role in the Selection of Autoreactive Class I-Restricted CD8 T Cells That Are Essential Contributors to Type 1 Diabetes Development in Nonobese Diabetic Mice David V. Serreze, T. Matthew Holl, Michele P. Marron, Robert T. Graser, Ellis A. Johnson, Caroline Choisy-Rossi, Robyn M. Slattery, Scott M. Lieberman, and Teresa P. DiLorenzo
871-879
Innate Immune Discrimination of Apoptotic Cells: Repression of Proinflammatory Macrophage Transcription Is Coupled Directly to Specific Recognition Marija Cvetanovic and David S. Ucker
880-889
Dual Role of CCR2 during Initiation and Progression of Collagen-Induced Arthritis: Evidence for Regulatory Activity of CCR2+ T Cells Hilke Brühl, Josef Cihak, Martin A. Schneider, Jirí Plachy, Tamara Rupp, Isabell Wenzel, Mehdi Shakarami, Stefan Milz, Joachim W. Ellwart, Manfred Stangassinger, Detlef Schlöndorff, and Matthias Mack
890-898
NKp44 Triggers NK Cell Activation through DAP12 Association That Is Not Influenced by a Putative Cytoplasmic Inhibitory Sequence Kerry S. Campbell, Sei-ichi Yusa, Akiko Kikuchi-Maki, and Tracey L. Catina
899-906
Invariant Chain and the MHC Class II Cytoplasmic Domains Regulate Localization of MHC Class II Molecules to Lipid Rafts in Tumor Cell-Based Vaccines Brian P. Dolan, Timothy P. Phelan, Dan Ilkovitch, Ling Qi, William F. Wade, Terri M. Laufer, and Suzanne Ostrand-Rosenberg
907-914
An Altered Self-Peptide with Superagonist Activity Blocks a CD8-Mediated Mouse Model of Type 1 Diabetes Agnès Hartemann-Heurtier, Lennart T. Mars, Nadège Bercovici, Sabine Desbois, Christophe Cambouris, Eliane Piaggio, Jacques Zappulla, Abdelhadi Saoudi, and Roland S. Liblau
915-922
Alloantigen-Induced CD25+CD4+ Regulatory T Cells Can Develop In Vivo from CD25-CD4+ Precursors in a Thymus-Independent Process Mahzuz Karim, Cherry I. Kingsley, Andrew R. Bushell, Birgit S. Sawitzki, and Kathryn J. Wood
923-928
TCR Vaccines against a Murine T Cell Lymphoma: A Primary Role for Antibodies of the IgG2c Class in Tumor Protection Stacie L. Lambert, Craig Y. Okada, and Ronald Levy
929-936
Regulation of Autoimmune Diabetes by Complete Freund’s Adjuvant Is Mediated by NK Cells I-Fang Lee, Huilian Qin, Jacqueline Trudeau, Jan Dutz, and Rusung Tan
937-942
Dissociation of NKT Stimulation, Cytokine Induction, and NK 943-953
Activation In Vivo by the Use of Distinct TCR-Binding Ceramides John R. Ortaldo, Howard A. Young, Robin T. Winkler-Pickett, Earl W. Bere, Jr., William J. Murphy, and Robert H. Wiltrout IL-12p70-Dependent Th1 Induction by Human B Cells Requires Combined Activation with CD40 Ligand and CpG DNA Moritz Wagner, Hendrik Poeck, Bernd Jahrsdoerfer, Simon Rothenfusser, Domenik Prell, Barbara Bohle, Evelyn Tuma, Thomas Giese, Joachim W. Ellwart, Stefan Endres, and Gunther Hartmann
954-963
Early Growth Response Gene 3 Regulates Thymocyte Proliferation during the Transition from CD4-CD8- to CD4+CD8+1 Hongkang Xi and Gilbert J. Kersh
964-971
The Cell Surface-Localized Heat Shock Protein 70 Epitope TKD Induces Migration and Cytolytic Activity Selectively in Human NK Cells Robert Gastpar, Catharina Gross, Lydia Rossbacher, Joachim Ellwart, Julia Riegger, and Gabriele Multhoff
972-980
A Switch in Costimulation from CD28 to 4-1BB during Primary versus Secondary CD8 T Cell Response to Influenza In Vivo Edward M. Bertram, Wojciech Dawicki, Bradley Sedgmen, Jonathan L. Bramson, David H. Lynch, and Tania H. Watts
981-988
Antigen-Specific Inhibition of CD8+ T Cell Response by Immature Myeloid Cells in Cancer Is Mediated by Reactive Oxygen Species Sergei Kusmartsev, Yulia Nefedova, Daniel Yoder, and Dmitry I. Gabrilovich
989-999
In a Transgenic Model of Spontaneous Autoimmune Diabetes, Expression of a Protective Class II MHC Molecule Results in Thymic Deletion of Diabetogenic CD8+ T Cells David J. Morgan, C. Thomas Nugent, Benjamin J. E. Raveney, and Linda A. Sherman
1000-1008
Liver Dendritic Cells Are Less Immunogenic Than Spleen Dendritic Cells because of Differences in Subtype Composition Venu G. Pillarisetty, Alaap B. Shah, George Miller, Joshua I. Bleier, and Ronald P. DeMatteo
1009-1017
Development of the Dendritic Cell System during Mouse Ontogeny Aleksandar Dakic, Qi-xiang Shao, Angela D’Amico, Meredith O’Keeffe, Wei-feng Chen, Ken Shortman, and Li Wu
1018-1027
IL-10 Induces Regulatory T Cell Apoptosis by Up-Regulation of the Membrane Form of TNF- Luciano E. Marra, Zhu X. Zhang, Betty Joe, Jon Campbell, Gary A. Levy, Josef
1028-1035
Ultraviolet Radiation-Induced Regulatory T Cells Not Only Inhibit the Induction but Can Suppress the Effector Phase of Contact Hypersensitivity Agatha Schwarz, Akira Maeda, Martin K. Wild, Kerstin Kernebeck, Nicole Gross, Yoshinori Aragane, Stefan Beissert, Dietmar Vestweber, and Thomas Schwarz
1036-1043
MOLECULAR AND STRUCTURAL IMMUNOLOGY Allelic Variation at the VHa Locus in Natural Populations of Rabbit (Oryctolagus cuniculus, L.) Pedro J. Esteves, Dennis Lanning, Nuno Ferrand, Katherine L. Knight,
1044-1053
Shi-Kang Zhai, and Wessel van der Loo NF-B and Oct-2 Synergize to Activate the Human 3' Igh hs4 Enhancer in B Cells Manuel A. Sepulveda, Alexander V. Emelyanov, and Barbara K. Birshtein
1054-1064
CD23 Trimers Are Preassociated on the Cell Surface Even in the Absence of Its Ligand, IgE Michelle A. Kilmon, Anne E. Shelburne, Yee Chan-Li, Kevin L. Holmes, and Daniel H. Conrad
1065-1073
Genomic Ly49A Transgenes: Basis of Variegated Ly49A Gene Expression and Identification of a Critical Regulatory Element Dawn M. Tanamachi, Deborah C. Moniot, Dragana Cado, Scot D. Liu, Jennifer K. Hsia, and David H. Raulet
1074-1082
Quantitative Analysis of Prion-Protein Degradation by Constitutive and Immuno-20S Proteasomes Indicates Differences Correlated with Disease Susceptibility Stefan Tenzer, Lars Stoltze, Birgitt Schönfisch, Jörn Dengjel, Margret Müller, Stefan Stevanovic, Hans-Georg Rammensee, and Hansjörg Schild
1083-1091
Polymorphisms in IL-4R Correlate with Airways Hyperreactivity, Eosinophilia, and Ym Protein Expression in Allergic IL-13-/- Mice Dianne C. Webb, Klaus I. Matthaei, Yeping Cai, Andrew N. J. McKenzie, and Paul S. Foster
1092-1098
Wnt Target Genes Identified by DNA Microarrays in Immature CD34+ Thymocytes Regulate Proliferation and Cell Adhesion Frank J. T. Staal, Floor Weerkamp, Miranda R. M. Baert, Caroline M. M. van den Burg, Mascha van Noort, Edwin F. E. de Haas, and Jacques J. M. van Dongen
1099-1108
Enhanced Catalytic Action of HLA-DM on the Exchange of Peptides Lacking Backbone Hydrogen Bonds between their N-Terminal Region and the MHC Class II -Chain Efstratios Stratikos, Don C. Wiley, and Lawrence J. Stern
1109-1117
Role of Commensal Bacteria in Development of Gut-Associated Lymphoid Tissues and Preimmune Antibody Repertoire Ki-Jong Rhee, Periannan Sethupathi, Adam Driks, Dennis K. Lanning, and Katherine L. Knight
1118-1124
HOST DEFENSE The Epidermal Growth Factor-Seven Transmembrane (EGF-TM7) Receptor CD97 Is Required for Neutrophil Migration and Host Defense Jaklien C. Leemans, Anje A. te Velde, Sandrine Florquin, Roelof J. Bennink, Kora de Bruin, René A. W. van Lier, Tom van der Poll, and Jörg Hamann
1125-1131
T Cytotoxic-1 CD8+ T Cells Are Effector Cells against Pneumocystis in Mice Florencia Mc Allister, Chad Steele, Mingquan Zheng, Erana Young, Judd E. Shellito, Luis Marrero, and Jay K. Kolls
1132-1138
IgE Enhances Parasite Clearance and Regulates Mast Cell Responses in Mice Infected with Trichinella spiralis Michael F. Gurish, Paul J. Bryce, Hong Tao, Alison B. Kisselgof, Elizabeth M. Thornton, Hugh R. Miller, Daniel S. Friend, and Hans C.
1139-1145
Oettgen The Cationic Antimicrobial Peptide LL-37 Modulates Dendritic Cell Differentiation and Dendritic Cell-Induced T Cell Polarization Donald J. Davidson, Andrew J. Currie, Gregor S. D. Reid, Dawn M. E. Bowdish, Kelly L. MacDonald, Rebecca C. Ma, Robert E. W. Hancock, and David P. Speert
1146-1156
The Role of SIGNR1 and the -Glucan Receptor (Dectin-1) in the Nonopsonic Recognition of Yeast by Specific Macrophages Philip R. Taylor, Gordon D. Brown, Jurgen Herre, David L. Williams, Janet A. Willment, and Siamon Gordon
1157-1162
Mice Deficient in LRG-47 Display Increased Susceptibility to Mycobacterial Infection Associated with the Induction of Lymphopenia Carl G. Feng, Carmen M. Collazo-Custodio, Michael Eckhaus, Sara Hieny, Yasmine Belkaid, Karen Elkins, Dragana Jankovic, Gregory A. Taylor, and Alan Sher
1163-1168
Staphylococcus aureus Resists Human Defensins by Production of Staphylokinase, a Novel Bacterial Evasion Mechanism Tao Jin, Maria Bokarewa, Timothy Foster, Jennifer Mitchell, Judy Higgins, and Andrej Tarkowski
1169-1176
Expression of Signaling Lymphocytic Activation Molecule- Associated Protein Interrupts IFN- Production in Human Tuberculosis Virginia Pasquinelli, María F. Quiroga, Gustavo J. Martínez, Liliana Castro Zorrilla, Rosa M. Musella, María M. Bracco, Liliana Belmonte, Alejandro Malbrán, Leonardo Fainboim, Peter A. Sieling, and Verónica E. García
1177-1185
The Dendritic Cell Receptor DC-SIGN Discriminates among Species and Life Cycle Forms of Leishmania María Colmenares, Angel L. Corbí, Salvatore J. Turco, and Luis Rivas
1186-1190
Generation of a Complement-Independent Bactericidal IgM against a Relapsing Fever Borrelia Sean E. Connolly, David G. Thanassi, and Jorge L. Benach
1191-1197
L-Ficolin Specifically Binds to Lipoteichoic Acid, a Cell Wall Constituent of Gram-Positive Bacteria, and Activates the Lectin Pathway of Complement Nicholas J. Lynch, Silke Roscher, Thomas Hartung, Siegfried Morath, Misao Matsushita, Daniela N. Maennel, Mikio Kuraya, Teizo Fujita, and Wilhelm J. Schwaeble
1198-1202
Identification of a Novel FcRIIIa-Associated Molecule That Contains Significant Homology to Porcine Cathelin Susan E. Sweeney and Yoon B. Kim
1203-1212
Different Functional Capacities of Latent and Lytic Antigen-Specific CD8 T Cells in Murine Gammaherpesvirus Infection Joshua J. Obar, Sarah G. Crist, David C. Gondek, and Edward J. Usherwood
1213-1219
INFLAMMATION Carbon Monoxide Inhibits T Lymphocyte Proliferation via Caspase-Dependent Pathway Ruiping Song, Raja S. Mahidhara, Zhihong Zhou, Rosemary A. Hoffman, Dai-Wu Seol, Richard A. Flavell, Timothy R. Billiar, Leo E. Otterbein, and Augustine M. K. Choi
1220-1226
Prostaglandin E2 Induces Degranulation-Independent Production of Vascular Endothelial Growth Factor by Human Mast Cells Raja M. Abdel-Majid and Jean S. Marshall
1227-1236
CXCR2-/- Mice Show Enhanced Susceptibility to Herpetic Stromal Keratitis: A Role for IL-6-Induced Neovascularization Kaustuv Banerjee, Partha S. Biswas, Bumseok Kim, Sujin Lee, and Barry T. Rouse
1237-1245
Semaphorin CD100 from Activated T Lymphocytes Induces Process Extension Collapse in Oligodendrocytes and Death of Immature Neural Cells Pascale Giraudon, Peggy Vincent, Carine Vuaillat, Olivier Verlaeten, Luis Cartier, Anne Marie-Cardine, Mireille Mutin, Armand Bensussan, Marie-Françoise Belin, and Laurence Boumsell
1246-1255
Chemokine Secretion of Rheumatoid Arthritis Synovial Fibroblasts Stimulated by Toll-Like Receptor 2 Ligands Matthias Pierer, Janine Rethage, Reinhart Seibl, Roger Lauener, Fabia Brentano, Ulf Wagner, Holm Hantzschel, Beat A. Michel, Renate E. Gay, Steffen Gay, and Diego Kyburz
1256-1265
Bone Marrow-Derived Progenitor Cells Are Important for Lung Repair after Lipopolysaccharide-Induced Lung Injury Mitsuhiro Yamada, Hiroshi Kubo, Seiichi Kobayashi, Kota Ishizawa, Muneo Numasaki, Shinsaku Ueda, Takashi Suzuki, and Hidetada Sasaki
1266-1272
CLINICAL IMMUNOLOGY Potential Targets of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor for Multiple Sclerosis Therapy Narender Nath, Shailendra Giri, Ratna Prasad, Avtar K. Singh, and Inderjit Singh
1273-1286
Defective Control of Latent Epstein-Barr Virus Infection in Systemic Lupus Erythematosus Insoo Kang, Timothy Quan, Helena Nolasco, Sung-Hwan Park, Myung Sun Hong, Jill Crouch, Eric G. Pamer, John Greg Howe, and Joe Craft
1287-1294
Periportal Fibrosis in Human Schistosoma mansoni Infection Is Associated with Low IL-10, Low IFN-, High TNF-, or Low RANTES, Depending on Age and Gender Mark Booth, Joseph K. Mwatha, Sarah Joseph, Frances M. Jones, Hilda Kadzo, Edmund Ireri, Frances Kazibwe, Jovanice Kemijumbi, Curtis Kariuki, Gachuhi Kimani, John H. Ouma, Narcis B. Kabatereine, Birgitte J. Vennervald, and David W. Dunne
1295-1303
Functional Analysis of Tumor-Specific Th Cell Responses Detected in Melanoma Patients after Dendritic Cell-Based Immunotherapy Erwin S. Schultz, Beatrice Schuler-Thurner, Vincent Stroobant, Lars Jenne, Thomas G. Berger, Kris Thielemanns, Pierre van der Bruggen, and Gerold Schuler
1304-1310
CORRECTIONS Interdependence of N Nucleotide Addition and Recombination Site Choice in V(D)J Rearrangement Thomas B. Kepler, Michelle Borrero, Beth Rugerio, Suzanne K. McCray, and Stephen H. Clarke
1311
IL-10 Mediates Suppression of the CD8 T Cell IFN-. Response to a Novel Viral Epitope in a Primed Host
1311
Xiao Song Liu, Yan Xu, Lani Hardy, Vithagna Khammanivong, Weiming Zhao, Germain J. P. Fernando, Graham R. Leggatt, and Ian H. Frazer
VOL.172, NO. 3, FEBRUARY 1; 2004 IN THIS ISSUE 1331-1332 BRIEF REVIEWS NK Cell Compartments and Their Activation by Dendritic Cells Guido Ferlazzo and Christian Münz
1333-1339
CUTTING EDGE Cutting Edge: Distinct TCR- and CD28-Derived Signals Regulate CD95L, Bcl-xL, and the Survival of Primary T Cells Andreas Kerstan and Thomas Hünig
1341-1345
CELLULAR IMMUNOLOGY AND IMMUNE REGULATION Induction of Tumor Regression by Administration of B7-Ig Fusion Proteins: Mediation by Type 2 CD8+ T Cells and Dependence on IL-4 Production Nobuya Yamaguchi, Shin-ichiro Hiraoka, Takao Mukai, Noritami Takeuchi, Xu-Yu Zhou, Shiro Ono, Mikihiko Kogo, Kyriaki Dunussi-Joannopoulos, Vincent Ling, Stanley Wolf, and Hiromi Fujiwara
1347-1354
Mechanistic Insights into Impaired Dendritic Cell Function by Rapamycin: Inhibition of Jak2/Stat4 Signaling Pathway Po-Hui Chiang, Lianfu Wang, C. Andrew Bonham, Xiaoyan Liang, John J. Fung, Lina Lu, and Shiguang Qian
1355-1363
Tolerance Induction by Intrathymic Expression of P0 Lucian Visan, Ioana A. Visan, Andreas Weishaupt, Harald H. Hofstetter, Klaus V. Toyka, Thomas Hünig, and Ralf Gold
1364-1370
Cellular Maturation Defects in Bruton’s Tyrosine Kinase-Deficient Immature B Cells Are Amplified by Premature B Cell Receptor Expression and Reduced by Receptor Editing Sabine Middendorp and Rudolf W. Hendriks
1371-1379
Tc1 and Tc2 Effector Cell Therapy Elicit Long-Term Tumor Immunity by Contrasting Mechanisms That Result in Complementary Endogenous Type 1 Antitumor Responses Mark J. Dobrzanski, Joyce B. Reome, Joseph A. Hollenbaugh, and Richard W. Dutton
1380-1390
IL-11 Protects Human Microvascular Endothelium from Alloinjury In Vivo by Induction of Survivin Expression Nancy C. Kirkiles-Smith, Keyvan Mahboubi, Janet Plescia, Jennifer M. McNiff, James Karras, Jeffrey S. Schechner, Dario C. Altieri, and Jordan S. Pober
1391-1396
Mature Human Thymocytes Migrate on Laminin-5 with Activation of Metalloproteinase-14 and Cleavage of CD44 Mylène Vivinus-Nebot, Patricia Rousselle, Jean-Philippe Breittmayer, Claire Cenciarini, Sonia Berrih-Aknin, Suzanne Spong, Pasi Nokelainen, Françoise Cottrez, M. Peter Marinkovich, and Alain Bernard
1397-1406
CCL17 and IL-10 as Effectors That Enable Alternatively Activated Macrophages to Inhibit the Generation of Classically Activated Macrophages
1407-1413
Tatsushi Katakura, Masaru Miyazaki, Makiko Kobayashi, David N. Herndon, and Fujio Suzuki Independent Control of Ly49g Alleles: Implications for NK Cell Repertoire Selection and Tumor Cell Killing Andrew P. Makrigiannis, Etienne Rousselle, and Stephen K. Anderson
1414-1425
Estrogen Preferentially Promotes the Differentiation of CD11c+ CD11bintermediate Dendritic Cells from Bone Marrow Precursors Vladislava Paharkova-Vatchkova, Ruben Maldonado, and Susan Kovats
1426-1436
Lck Is Required for Activation-Induced T Cell Death after TCR Ligation with Partial Agonists Xue-Zhong Yu, Steven D. Levin, Joaquin Madrenas, and Claudio Anasetti
1437-1443
Chimeric Donor Cells Play an Active Role in Both Induction and Maintenance Phases of Transplantation Tolerance Induced by Mixed Chimerism Akira Kanamoto and Takashi Maki
1444-1448
Importance of IL-10 for CTLA-4-Mediated Inhibition of Tumor-Eradicating Immunity Vladimir M. Jovasevic, Leonid Gorelik, Jeffrey A. Bluestone, and Margalit B. Mokyr
1449-1454
The Abundant NK Cells in Human Secondary Lymphoid Tissues Require Activation to Express Killer Cell Ig-Like Receptors and Become Cytolytic Guido Ferlazzo, Dolca Thomas, Shao-Lee Lin, Kiera Goodman, Barbara Morandi, William A. Muller, Alessandro Moretta, and Christian Münz
1455-1462
Production of Donor T Cells Is Critical for Induction of Donor-Specific Tolerance and Maintenance of Chimerism Hong Xu, Paula M. Chilton, Yiming Huang, Carrie L. Schanie, and Suzanne T. Ildstad
1463-1471
-Associated Protein of 70 kDa (ZAP-70), but Not Syk, Tyrosine Kinase Can Mediate Apoptosis of T Cells through the Fas/Fas Ligand, Caspase-8 and Caspase-3 Pathways Lingwen Zhong, Chun-Hua Wu, Wen-Hui Lee, and Chih-Pin Liu
1472-1482
Zwitterionic Polysaccharides Stimulate T Cells with No Preferential V Usage and Promote Anergy, Resulting in Protection against Experimental Abscess Formation Francesca Stingele, Blaise Corthésy, Nicole Kusy, Steven A. Porcelli, Dennis L. Kasper, and Arthur O. Tzianabos
1483-1490
Effect of Chronic Viral Infection on Epitope Selection, Cytokine Production, and Surface Phenotype of CD8 T Cells and the Role of IFN- Receptor in Immune Regulation Kavita Tewari, Jonah Sacha, Xiaoyan Gao, and M. Suresh
1491-1500
CpG-DNA Aided Cross-Priming by Cross-Presenting B Cells Antje Heit, Katharina M. Huster, Frank Schmitz, Matthias Schiemann, Dirk H. Busch, and Hermann Wagner
1501-1507
Tumor-Infiltrating Lymphocyte Secretion of IL-6 Antagonizes Tumor-Derived TGF-1 and Restores the Lymphokine-Activated Killing Activity Ya-Wen Hsiao, Kuang-Wen Liao, Shao-Wen Hung, and Rea-Min Chu
1508-1514
Expression of Dual TCR on DO11.10 T Cells Allows for Ovalbumin- 1515-1523
Induced Oral Tolerance to Prevent T Cell-Mediated Colitis Directed against Unrelated Enteric Bacterial Antigens Pengfei Zhou, Rajka Borojevic, Cathy Streutker, Denis Snider, Hong Liang, and Kenneth Croitoru Early Adenoviral Gene Expression Mediates Immunosuppression by Transduced Dendritic Cell (DC): Implications for Immunotherapy Using Genetically Modified DC Andrea Tuettenberg, Helmut Jonuleit, Thomas Tüting, Jürgen Brück, Volker Biermann, Stefan Kochanek, Jürgen Knop, and Alexander H. Enk
1524-1530
CD4+ and CD8+ Regulatory T Cells Generated Ex Vivo with IL-2 and TGF- Suppress a Stimulatory Graft-versus-Host Disease with a Lupus-Like Syndrome Song Guo Zheng, Ju Hua Wang, Michael N. Koss, Francisco Quismorio, Jr., J. Dixon Gray, and David Allen Horwitz
1531-1539
IL-21 Induces Tumor Rejection by Specific CTL and IFN--Dependent CXC Chemokines in Syngeneic Mice Emma Di Carlo, Alberto Comes, Anna Maria Orengo, Ombretta Rosso, Raffaella Meazza, Piero Musiani, Mario P. Colombo, and Silvano Ferrini
1540-1547
Deceptive Multilineage Reconstitution Analysis of Mice Transplanted with Hemopoietic Stem Cells, and Implications for Assessment of Stem Cell Numbers and Lineage Potentials David Bryder, Yutaka Sasaki, Ole Johan Borge, and Sten-Eirik W. Jacobsen
1548-1552
Autoreactive B Cells in Lupus-Prone New Zealand Black Mice Exhibit Aberrant Survival and Proliferation in the Presence of Self-Antigen In Vivo Nan-Hua Chang, Ralph MacLeod, and Joan E. Wither
1553-1560
Phosphatidylinositol 3-Kinase Is a Determinant of Responsiveness to B Cell Antigen Receptor-Mediated Epstein-Barr Virus Activation Dai Iwakiri and Kenzo Takada
1561-1566
Intraocular Tumor Antigen Drains Specifically to Submandibular Lymph Nodes, Resulting in an Abortive Cytotoxic T Cell Reaction Zita F. H. M. Boonman, Geertje J. D. van Mierlo, Marieke F. Fransen, Kees L. M. C. Franken, Rienk Offringa, Cornelis J. M. Melief, Martine J. Jager, and René E. M. Toes
1567-1574
E-Selectin, Thymus- and Activation-Regulated Chemokine/CCL17, and Intercellular Adhesion Molecule-1 Are Constitutively Coexpressed in Dermal Microvessels: A Foundation for a Cutaneous Immunosurveillance System Benjamin F. Chong, Jo-Ellen Murphy, Thomas S. Kupper, and Robert C. Fuhlbrigge
1575-1581
Intravenous Injection of a Lentiviral Vector Encoding NY-ESO-1 Induces an Effective CTL Response Michael J. Palmowski, Luciene Lopes, Yasuhiro Ikeda, Mariolina Salio, Vincenzo Cerundolo, and Mary K. Collins
1582-1587
IFN- Promotes Fas Ligand- and Perforin-Mediated Liver Cell Destruction by Cytotoxic CD8 T Cells Evelyn Roth and Hanspeter Pircher
1588-1594
Escherichia coli Expressing Recombinant Antigen and Listeriolysin O Stimulate Class I-Restricted CD8+ T Cells following Uptake by Human APC Paul Q. Hu, Renee J. Tuma-Warrino, Marianne A. Bryan, Kathleen G. Mitchell, Darren E. Higgins, Simon C. Watkins, and Russell D. Salter
1595-1601
Characterization of Defective CD4-CD8- T Cells in Murine Tumors Generated Independent of Antigen Specificity Robert M. Prins, Francesca Incardona, Regan Lau, Paul Lee, Sarah Claus, Wenxuan Zhang, Keith L. Black, and Christopher J. Wheeler
1602-1611
Regulation of c-Jun N-Terminal Kinase by MEKK-2 and Mitogen-Activated Protein Kinase Kinase Kinases in Rheumatoid Arthritis Deepa R. Hammaker, David L. Boyle, Martine Chabaud-Riou, and Gary S. Firestein
1612-1618
The Role of TNF-Related Activation-Induced Cytokine–Receptor Activating NF-B Interaction in Acute Allograft Rejection and CD40L-Independent Chronic Allograft Rejection Carole Guillonneau, Cédric Louvet, Karine Renaudin, Jean-Marie Heslan, Michèle Heslan, Laurent Tesson, Caroline Vignes, Cécile Guillot, Yongwon Choi, Lawrence A. Turka, Maria-Cristina Cuturi, Ignacio Anegon, and Régis Josien
1619-1629
Blockade of Lymphotoxin Signaling Inhibits the Clinical Expression of Murine Graft-versus-Host Skin Disease Qiang Wu, Yang-Xin Fu, and Richard D. Sontheimer
1630-1636
Ontogeny of T Cells in Humans Stephen C. De Rosa, James P. Andrus, Stephen P. Perfetto, John J. Mantovani, Leonard A. Herzenberg, Leonore A. Herzenberg, and Mario Roederer
1637-1645
IFN- Induced Adenosine Production on the Endothelium: A Mechanism Mediated by CD73 (Ecto-5'-Nucleotidase) Up-Regulation Jussi Niemelä, Tiina Henttinen, Gennady G. Yegutkin, Laura Airas, Anna-Maija Kujari, Pertti Rajala, and Sirpa Jalkanen
1646-1653
Nuclear Pro-IL-16 Regulation of T Cell Proliferation: p27KIP1-Dependent G0/G1 Arrest Mediated by Inhibition of Skp2 Transcription David M. Center, William W. Cruikshank, and Yujun Zhang
1654-1660
MOLECULAR AND STRUCTURAL IMMUNOLOGY The Nonclassical MHC Class I Molecule Qa-1 Forms Unstable Peptide Complexes Taku Kambayashi, Jennifer R. Kraft-Leavy, Joseph G. Dauner, Barbara A. Sullivan, Oskar Laur, and Peter E. Jensen
1661-1669
The C4A and C4B Isotypic Forms of Human Complement Fragment C4b Have the Same Intrinsic Affinity for Complement Receptor 1 (CR1/CD35) Liliana Clemenza and David E. Isenman
1670-1680
Hypoxia Selectively Inhibits Monocyte Chemoattractant Protein-1 Production by Macrophages Maria Carla Bosco, Maura Puppo, Sandra Pastorino, Zenghui Mi, Giovanni Melillo, Stefano Massazza, Annamaria Rapisarda, and Luigi Varesio
1681-1690
Critical Role of OX40 in CD28 and CD154-Independent Rejection Gülçin Demirci, Farhana Amanullah, Reshma Kewalaramani, Hideo
1691-1698
Yagita, Terry B. Strom, Mohamed H. Sayegh, and Xian Chang Li HOST DEFENSE IFN- Sensitizes Human Umbilical Vein Endothelial Cells to Apoptosis Induced by Double-Stranded RNA William J. Kaiser, Jonathan L. Kaufman, and Margaret K. Offermann
1699-1710
Impaired Production of Proinflammatory Cytokines and Host Resistance to Acute Infection with Trypanosoma cruzi in Mice Lacking Functional Myeloid Differentiation Factor 88 Marco A. Campos, Meire Closel, Eneida P. Valente, Jarbas E. Cardoso, Shizuo Akira, Jacqueline I. Alvarez-Leite, Catherine Ropert, and Ricardo T. Gazzinelli
1711-1718
HLA Class II Polymorphisms Determine Responses to Bacterial Superantigens Martin Llewelyn, Shiranee Sriskandan, Mark Peakman, David R. Ambrozak, Daniel C. Douek, William W. Kwok, Jonathan Cohen, and Daniel M. Altmann
1719-1726
Dendritic Cells Pulsed with Live and Dead Legionella pneumophila Elicit Distinct Immune Responses Toshiaki Kikuchi, Takao Kobayashi, Kazunori Gomi, Takuji Suzuki, Yutaka Tokue, Akira Watanabe, and Toshihiro Nukiwa
1727-1734
Human T Cell Lymphotropic Virus Type I (HTLV-I)-Specific CD4+ T Cells: Immunodominance Hierarchy and Preferential Infection with HTLV-I Peter K. C. Goon, Tadahiko Igakura, Emmanuel Hanon, Angelina J. Mosley, Anna Barfield, Amanda L. Barnard, Lambrini Kaftantzi, Yuetsu Tanaka, Graham P. Taylor, Jonathan N. Weber, and Charles R. M. Bangham
1735-1743
Pervasive Influence of Hepatitis C Virus on the Phenotype of Antiviral CD8+ T Cells Michaela Lucas, Ana L. Vargas-Cuero, Georg M. Lauer, Eleanor Barnes, Christian B. Willberg, Nasser Semmo, Bruce D. Walker, Rodney Phillips, and Paul Klenerman
1744-1753
Distinct Modulatory Effects of LPS and CpG on IL-18-Dependent IFN- Synthesis Meetha P. Gould, Jennifer A. Greene, Vijay Bhoj, Jennifer L. DeVecchio, and Frederick P. Heinzel
1754-1762
Selective Killing of Vaccinia Virus by LL-37: Implications for Eczema Vaccinatum Michael D. Howell, James F. Jones, Kevin O. Kisich, Joanne E. Streib, Richard L. Gallo, and Donald Y. M. Leung
1763-1767
Chlamydia pneumoniae Multiply in Neutrophil Granulocytes and Delay Their Spontaneous Apoptosis Ger van Zandbergen, Jens Gieffers, Henning Kothe, Jan Rupp, Annalena Bollinger, Eresso Aga, Matthias Klinger, Helmut Brade, Klaus Dalhoff, Matthias Maass, Werner Solbach, and Tamás Laskay
1768-1776
Nonmethylated CG Motifs Packaged into Virus-Like Particles Induce Protective Cytotoxic T Cell Responses in the Absence of Systemic Side Effects Tazio Storni, Christiane Ruedl, Katrin Schwarz, Reto A. Schwendener, Wolfgang A. Renner, and Martin F. Bachmann
1777-1785
Overproduction of TNF- by CD8+ Type 1 Cells and Down-Regulation of IFN- Production by CD4+ Th1 Cells Contribute to Toxic Shock-Like Syndrome in an Animal Model of Fatal Monocytotropic Ehrlichiosis Nahed Ismail, Lynn Soong, Jere W. McBride, Gustavo Valbuena, Juan P. Olano, Hui-Min Feng, and David H. Walker
1786-1800
p47phox Deficiency Impairs NF-B Activation and Host Defense in Pseudomonas Pneumonia Ruxana T. Sadikot, Heng Zeng, Fiona E. Yull, Bo Li, Dong-sheng Cheng, Douglas S. Kernodle, E. Duco Jansen, Christopher H. Contag, Brahm H. Segal, Steven M. Holland, Timothy S. Blackwell, and John W. Christman
1801-1808
INFLAMMATION Leptin Indirectly Activates Human Neutrophils via Induction of TNF- Hamid Zarkesh-Esfahani, Alan G. Pockley, Zida Wu, Paul G. Hellewell, Anthony P. Weetman, and Richard J. M. Ross
1809-1814
Transcript Signatures in Experimental Asthma: Identification of STAT6-Dependent and -Independent Pathways Nives Zimmermann, Anil Mishra, Nina E. King, Patricia C. Fulkerson, Matthew P. Doepker, Nikolaos M. Nikolaidis, Laura E. Kindinger, Elizabeth A. Moulton, Bruce J. Aronow, and Marc E. Rothenberg
1815-1824
Macrophage-Stimulating Protein, the Ligand for the Stem Cell-Derived Tyrosine Kinase/RON Receptor Tyrosine Kinase, Inhibits IL-12 Production by Primary Peritoneal Macrophages Stimulated with IFN- and Lipopolysaccharide Amy C. Morrison, Caleph B. Wilson, Manujendra Ray, and Pamela H. Correll
1825-1832
Cysteinyl Leukotrienes Regulate Dendritic Cell Functions in a Murine Model of Asthma Ikuko Machida, Hiroto Matsuse, Yuki Kondo, Tetsuya Kawano, Sachiko Saeki, Shinya Tomari, Yasushi Obase, Chizu Fukushima, and Shigeru Kohno
1833-1838
Kinin B1 Receptor Up-Regulation after Lipopolysaccharide Administration: Role of Proinflammatory Cytokines and Neutrophil Influx Giselle F. Passos, Elizabeth S. Fernandes, Maria M. Campos, José G. V. C. Araújo, Jorge L. Pesquero, Glória E. P. Souza, Maria C. W. Avellar, Mauro M. Teixeira, and João B. Calixto
1839-1847
The Essential Involvement of Cross-Talk between IFN- and TGF- in the Skin Wound-Healing Process Yuko Ishida, Toshikazu Kondo, Tatsunori Takayasu, Yoichiro Iwakura, and Naofumi Mukaida
1848-1855
A Molecular Defect in Intracellular Lipid Signaling in Human Neutrophils in Localized Aggressive Periodontal Tissue Damage Karsten Gronert, Alpdogan Kantarci, Bruce D. Levy, Clary B. Clish, Sabine Odparlik, Hatice Hasturk, John A. Badwey, Sean P. Colgan, Thomas E. Van Dyke, and Charles N. Serhan
1856-1861
Expression of CD154 (CD40 Ligand) by Human Lung Fibroblasts: Differential Regulation by IFN- and IL-13, and Implications for Fibrosis Julia Kaufman, Patricia J. Sime, and Richard P. Phipps
1862-1871
The C10/CCL6 Chemokine and CCR1 Play Critical Roles in the 1872-1881
Pathogenesis of IL-13-Induced Inflammation and Remodeling Bing Ma, Zhou Zhu, Robert J. Homer, Craig Gerard, Robert Strieter, and Jack A. Elias Immune Complexes Bind Preferentially to FcRIIA (CD32) on Apoptotic Neutrophils, Leading to Augmented Phagocytosis by Macrophages and Release of Proinflammatory Cytokines Simon P. Hart, Karen M. Alexander, and Ian Dransfield
882-1887
Induction of C Chemokine XCL1 (Lymphotactin/Single C Motif-1/Activation-Induced, T Cell-Derived and Chemokine-Related Cytokine) Expression by HIV-1 Tat Protein Byung Oh Kim, Ying Liu, Betty Y. Zhou, and Johnny J. He
1888-1895
Chemotaxis and Calcium Responses of Phagocytes to Formyl Peptide Receptor Ligands Is Differentially Regulated by Cyclic ADP Ribose Santiago Partida-Sánchez, Pablo Iribarren, Miguel E. Moreno-García, Ji-Liang Gao, Philip M. Murphy, Norman Oppenheimer, Ji Ming Wang, and Frances E. Lund
1896-1906
TNF--Induced Apoptosis of Macrophages Following Inhibition of NF-B: A Central Role for Disruption of Mitochondria Hongtao Liu, Yingyu Ma, Lisa J. Pagliari, Harris Perlman, Chenfei Yu, Anning Lin, and Richard M. Pope
1907-1915
CLINICAL IMMUNOLOGY Lymphoid Hyperplasia Resulting in Immune Dysregulation Is Caused by Porcine Reproductive and Respiratory Syndrome Virus Infection in Neonatal Pigs Caitlin D. Lemke, Joseph S. Haynes, Rodger Spaete, Deb Adolphson, Ann Vorwald, Kelly Lager, and John E. Butler
1916-1925
Metal-Protein Complex-Mediated Transport and Delivery of Ni2+ to TCR/MHC Contact Sites in Nickel-Specific Human T Cell Activation Hermann-Josef Thierse, Corinne Moulon, Yvonne Allespach, Bastian Zimmermann, Andrea Doetze, Stephan Kuppig, Doris Wild, Friedrich Herberg, and Hans Ulrich Weltzien
1926-1934
Nucleotide Sequencing of Psoriatic Arthritis Tissue before and during Methotrexate Administration Reveals a Complex Inflammatory T Cell Infiltrate with Very Few Clones Exhibiting Features That Suggest They Drive the Inflammatory Process by Recognizing Autoantigens Shane A. Curran, Oliver M. FitzGerald, Patrick J. Costello, Jeanette M. Selby, David J. Kane, Barry Bresnihan, and Robert Winchester
1935-1944
Ets-1 Regulates TNF--Induced Matrix Metalloproteinase-9 and Tenascin Expression in Primary Bronchial Fibroblasts Yutaka Nakamura, Stéphane Esnault, Takashi Maeda, Elizabeth A. B. Kelly, James S. Malter, and Nizar N. Jarjour
1945-1952
Mycobacterium tuberculosis Recall Antigens Suppress HIV-1 Replication in Anergic Donor Cells via CD8+ T Cell Expansion and Increased IL-10 Levels Shahin Ranjbar, Nary Ly, Sok Thim, Jean-Marc Reynes, and Anne E. Goldfeld
1953-1959
Molecular Analysis of TCR Clonotypes in LGL: A Clonal Model for Polyclonal Responses Christine L. O’Keefe, Magdalena Plasilova, Marcin Wlodarski, Antonio M. Risitano, Alexander R. Rodriguez, Evan Howe, Neal S. Young, Eric
1960-1969
Hsi, and Jaroslaw P. Maciejewski VOL.172, NO. 4, FEBRUARY 15; 2004
IN THIS ISSUE 1989-1990CUTTING EDGE Cutting Edge: In Vitro-Generated Tolerogenic APC Induce CD8+ T Regulatory Cells That Can Suppress Ongoing Experimental Autoimmune Encephalomyelitis Douglas E. Faunce, Ania Terajewicz, and Joan Stein-Streilein
1991-1995
Cutting Edge: Conventional CD8+ Dendritic Cells Are Generally Involved in Priming CTL Immunity to Viruses Gabrielle T. Belz, Christopher M. Smith, Daniel Eichner, Ken Shortman, Guna Karupiah, Francis R. Carbone, and William R. Heath
1996-2000
Cutting Edge: Toll-Like Receptor Signaling in Macrophages Induces Ligands for the NKG2D Receptor Jessica A. Hamerman, Kouetsu Ogasawara, and Lewis L. Lanier
2001-2005
Cutting Edge: IL-26 Signals through a Novel Receptor Complex Composed of IL-20 Receptor 1 and IL-10 Receptor 2 Faruk Sheikh, Vitaliy V. Baurin, Anita Lewis-Antes, Nital K. Shah, Sergey V. Smirnov, Shubha Anantha, Harold Dickensheets, Laure Dumoutier, Jean-Christophe Renauld, Alexander Zdanov, Raymond P. Donnelly, and Sergei V. Kotenko
2006-2010
Cutting Edge: T Cells Trigger CD40-Dependent Platelet Activation and Granular RANTES Release: A Novel Pathway for Immune Response Amplification Silvio Danese, Carol de la Motte, Brenda M. Rivera Reyes, Miquel Sans, Alan D. Levine, and Claudio Fiocchi
2011-2015
Cutting Edge: Dendritic Cells Copulsed with Microbial and Helminth Antigens Undergo Modified Maturation, Segregate the Antigens to Distinct Intracellular Compartments, and Concurrently Induce Microbe-Specific Th1 and Helminth-Specific Th2 Responses Laura Cervi, Andrew S. MacDonald, Colleen Kane, Florence Dzierszinski, and Edward J. Pearce
2016-2020
CELLULAR IMMUNOLOGY AND IMMUNE REGULATION Visualizing the Site and Dynamics of IgG Salvage by the MHC Class I-Related Receptor, FcRn Raimund J. Ober, Cruz Martinez, Carlos Vaccaro, Jinchun Zhou, and E. Sally Ward
2021-2029
Visualization of Antigen Presentation by Actin-Mediated Targeting of Glycolipid-Enriched Membrane Domains to the Immune Synapse of B Cell APCs Claire Gordy, Sudha Mishra, and William Rodgers
2030-2038
Inhibitory Effect of Toll-Like Receptor 4 on Fusion between Phagosomes and Endosomes/Lysosomes in Macrophages Akiko Shiratsuchi, Ikuko Watanabe, Osamu Takeuchi, Shizuo Akira, and Yoshinobu Nakanishi
2039-2047
IL-21 Induces the Functional Maturation of Murine NK Cells Jason Brady, Yoshihiro Hayakawa, Mark J. Smyth, and Stephen L. Nutt
2048-2058
IL-4 Induces Differentiation and Expansion of Th2 Cytokine-Producing Eosinophils
2059-2066
Luqiu Chen, Kristy A. Grabowski, Jun-ping Xin, John Coleman, Zan Huang, Baltazar Espiritu, Serhan Alkan, H. Bill Xie, Yuechun Zhu, Fletcher A. White, John Clancy, Jr, and Hua Huang NF-B-Inducing Kinase Establishes Self-Tolerance in a Thymic Stroma-Dependent Manner Fumiko Kajiura, Shijie Sun, Takashi Nomura, Keisuke Izumi, Tomoo Ueno, Yoshimi Bando, Noriyuki Kuroda, Hongwei Han, Yi Li, Akemi Matsushima, Yousuke Takahama, Shimon Sakaguchi, Tasuku Mitani, and Mitsuru Matsumoto
2067-2075
Mechanisms Governing B Cell Developmental Defects in Invariant Chain-Deficient Mice Kamel Benlagha, Se-Ho Park, Rodolphe Guinamard, Claire Forestier, Lars Karlsson, Cheong-Hee Chang, and Albert Bendelac
2076-2083
B Cell Receptor-Mediated Apoptosis of Human Lymphocytes Is Associated with a New Regulatory Pathway of Bim Isoform Expression Shahul Mouhamad, Laurence Besnault, Marie Thérèse Auffredou, Corinne Leprince, Marie Françoise Bourgeade, Gérald Leca, and Aimé Vazquez
2084-2091
Transgenic Expression of a Human Polyreactive Ig Expressed in Chronic Lymphocytic Leukemia Generates Memory-Type B Cells That Respond to Nonspecific Immune Activation George F. Widhopf, II, Diana C. Brinson, Thomas J. Kipps, and Helen Tighe
2092-2099
Severely Impaired B Lymphocyte Proliferation, Survival, and Induction of the c-Myc:Cullin 1 Ubiquitin Ligase Pathway Resulting from CD22 Deficiency on the C57BL/6 Genetic Background Jonathan C. Poe, Karen M. Haas, Junji Uchida, Youngkyun Lee, Manabu Fujimoto, and Thomas F. Tedder
2100-2110
Distinct Expression Profiles of the Peripheral Cannabinoid Receptor in Lymphoid Tissues Depending on Receptor Activation Status Nazik Rayman, King H. Lam, Jon D. Laman, Peter J. Simons, Bob Löwenberg, Pieter Sonneveld, and Ruud Delwel
2111-2117
Complete Loss of Fas Ligand Gene Causes Massive Lymphoproliferation and Early Death, Indicating a Residual Activity of gld Allele Saoussen Karray, Chantal Kress, Sylvain Cuvellier, Catherine Hue-Beauvais, Diane Damotte, Charles Babinet, and Matthieu Lévi-Strauss
2118-2125
Exosomes as Potent Cell-Free Peptide-Based Vaccine. I. Dendritic Cell-Derived Exosomes Transfer Functional MHC Class I/Peptide Complexes to Dendritic Cells Fabrice André, Nathalie Chaput, Nöel E. C. Schartz, Caroline Flament, Nathalie Aubert, Jacky Bernard, François Lemonnier, Graça Raposo, Bernard Escudier, Di-Hwei Hsu, Thomas Tursz, Sebastian Amigorena, Eric Angevin, and Laurence Zitvogel
2126-2136
Exosomes as Potent Cell-Free Peptide-Based Vaccine. II. Exosomes in CpG Adjuvants Efficiently Prime Naive Tc1 Lymphocytes Leading to Tumor Rejection Nathalie Chaput, Nöel E. C. Schartz, Fabrice André, Julien Taïeb, Sophie Novault, Pierre Bonnaventure, Nathalie Aubert, Jacky Bernard, François Lemonnier, Miriam Merad, Gosse Adema, Malcolm Adams,
2137-2146
Maria Ferrantini, Antoine F. Carpentier, Bernard Escudier, Thomas Tursz, Eric Angevin, and Laurence Zitvogel Novel Regulatory Mechanisms of CD40-Induced Prostanoid Synthesis by IL-4 and IL-10 in Human Monocytes Yasushi Inoue, Takeshi Otsuka, Hiroaki Niiro, Shuji Nagano, Yojirou Arinobu, Eiichi Ogami, Mitsuteru Akahoshi, Katsuhisa Miyake, Ichiro Ninomiya, Sakiko Shimizu, Hitoshi Nakashima, and Mine Harada
2147-2154
Reduced Ig Class Switch in Aged Mice Correlates with Decreased E47 and Activation-Induced Cytidine Deaminase Daniela Frasca, Elaine Van der Put, Richard L. Riley, and Bonnie B. Blomberg
2155-2162
Dependency of Direct Pathway CD4+ T Cells on CD40-CD154 Costimulation Is Determined by Nature and Microenvironment of Primary Contact with Alloantigen Andre van Maurik, Barbara Fazekas de St. Groth, Kathryn J. Wood, and Nick D. Jones
2163-2170
Disparate In Vitro and In Vivo Requirements for IL-2 During Antigen-Independent CD8 T Cell Expansion Phillip Wong and Eric G. Pamer
2171-2176
A Novel Role for an Insect Apolipoprotein (Apolipophorin III) in -1,3-Glucan Pattern Recognition and Cellular Encapsulation Reactions Miranda M. A. Whitten, Ian F. Tew, Bok L. Lee, and Norman A. Ratcliffe
2177-2185
Extremely Rapid and Intense Induction of Apoptosis in Human Eosinophils by Anti-CD30 Antibody Treatment In Vitro Kenji Matsumoto, Maki Terakawa, Kenju Miura, Shuhei Fukuda, Toshiharu Nakajima, and Hirohisa Saito
2186-2193
Resistance of Short Term Activated T Cells to CD95-Mediated Apoptosis Correlates with De Novo Protein Synthesis of c-FLIPshort Ingo Schmitz, Heiko Weyd, Andreas Krueger, Sven Baumann, Stefanie C. Fas, Peter H. Krammer, and Sabine Kirchhoff
2194-2200
IL-10-Conditioned Dendritic Cells, Decommissioned for Recruitment of Adaptive Immunity, Elicit Innate Inflammatory Gene Products in Response to Danger Signals Kathleen F. Nolan, Victoria Strong, Dulce Soler, Paul J. Fairchild, Stephen P. Cobbold, Ruth Croxton, Jose-Angel Gonzalo, Ana Rubio, Meghan Wells, and Herman Waldmann
2201-2209
The Cytoplasmic Domain of Ig Is Necessary and Sufficient to Support Efficient Early B Cell Development Kelly A. Pike, Sandra Iacampo, Jennifer E. Friedmann, and Michael J. H. Ratcliffe
2210-2218
HIV-Infected Langerhans Cells Preferentially Transmit Virus to Proliferating Autologous CD4+ Memory T Cells Located within Langerhans Cell-T Cell Clusters Makoto Sugaya, Karin Loré, Richard A. Koup, Daniel C. Douek, and Andrew Blauvelt
2219-2224
WSX-1 and Glycoprotein 130 Constitute a Signal-Transducing Receptor for IL-27 Stefan Pflanz, Linda Hibbert, Jeanine Mattson, Rency Rosales, Elena Vaisberg, J. Fernando Bazan, Joseph H. Phillips, Terrill K.
2225-2231
McClanahan, Rene de Waal Malefyt, and Robert A. Kastelein Identification of New Antigenic Peptide Presented by HLA-Cw7 and Encoded by Several MAGE Genes Using Dendritic Cells Transduced with Lentiviruses Karine Breckpot, Carlo Heirman, Catherine De Greef, Pierre van der Bruggen, and Kris Thielemans
2232-2237
Antigen Nonspecific Suppression of T Cell Responses by Activated Stimulation-Refractory CD4+ T Cells Christine T. Duthoit, Phuong Nguyen, and Terrence L. Geiger
2238-2246
The Impact of Thymic Antigen Diversity on the Size of the Selected T Cell Repertoire Jose Faro, Santiago Velasco, África González-Fernández, and Antonio Bandeira
2247-2255
Human Cytomegalovirus Proteins pp65 and Immediate Early Protein 1 Are Common Targets for CD8+ T Cell Responses in Children with Congenital or Postnatal Human Cytomegalovirus Infection Laura Gibson, Giampiero Piccinini, Daniele Lilleri, Maria Grazia Revello, Zhongde Wang, Susan Markel, Don J. Diamond, and Katherine Luzuriaga
2256-2264
NF-B Controls Cell Fate Specification, Survival, and Molecular Differentiation of Immunoregulatory Natural T Lymphocytes Aleksandar K. Stanic, Jelena S. Bezbradica, Jang-June Park, Naoto Matsuki, Ana L. Mora, Luc Van Kaer, Mark R. Boothby, and Sebastian Joyce
2265-2273
Adjuvant Costimulation during Secondary Antigen Challenge Directs Qualitative Aspects of Oral Tolerance Induction, Particularly during the Neonatal Period Iriani T. Tobagus, Wayne R. Thomas, and Patrick G. Holt
2274-2285
CD4+ T Cells Regulate CD8+ T Cell-Mediated Cutaneous Immune Responses by Restricting Effector T Cell Development through a Fas Ligand-Dependent Mechanism Anton V. Gorbachev and Robert L. Fairchild
2286-2295
Reduced Thymocyte Development in Sonic Hedgehog Knockout Embryos Divya K. Shah, Ariadne L. Hager-Theodorides, Susan V. Outram, Susan E. Ross, Alberto Varas, and Tessa Crompton
2296-2306
MOLECULAR AND STRUCTURAL IMMUNOLOGY Dendritic Cell Maturation Requires STAT1 and Is under Feedback Regulation by Suppressors of Cytokine Signaling Sharon H. Jackson, Cheng-Rong Yu, Rashid M. Mahdi, Samuel Ebong, and Charles E. Egwuagu
2307-2315
Caspase-3 Is a Component of Fas Death-Inducing Signaling Complex in Lipid Rafts and Its Activity Is Required for Complete Caspase-8 Activation during Fas-Mediated Cell Death Salah M. Aouad, Luchino Y. Cohen, Ehsan Sharif-Askari, Elias K. Haddad, Antoine Alam, and Rafick-Pierre Sekaly
2316-2323
The Impact of Self-Tolerance on the Polyclonal CD8+ T Cell Repertoire Helmut W. H. G. Kessels, Karin E. de Visser, Felicia H. Tirion, Miriam Coccoris, Ada M. Kruisbeek, and Ton N. M. Schumacher
2324-2331
Activation of Discoidin Domain Receptor 1 Isoform b with Collagen 2332-2340
Up-Regulates Chemokine Production in Human Macrophages: Role of p38 Mitogen-Activated Protein Kinase and NF-B Wataru Matsuyama, Lihua Wang, William L. Farrar, Michel Faure, and Teizo Yoshimura Immunosuppressive Activity of Endovanilloids: N-Arachidonoyl-Dopamine Inhibits Activation of the NF-B, NFAT, and Activator Protein 1 Signaling Pathways Rocío Sancho, Antonio Macho, Laureano de La Vega, Marco A. Calzado, Bernd L. Fiebich, Giovanni Appendino, and Eduardo Muñoz
2341-2351
Molecular Characterization of Human 4Ig-B7-H3, a Member of the B7 Family with Four Ig-Like Domains Peter Steinberger, Otto Majdic, Sophia V. Derdak, Katharina Pfistershammer, Stefanie Kirchberger, Christoph Klauser, Gerhard Zlabinger, Winfried F. Pickl, Johannes Stöckl, and Walter Knapp
2352-2359
Biases in Ig Light Chain Rearrangements in Human Intestinal Plasma Cells Wen Su, Laurent Boursier, Archana Padala, Jeremy D. Sanderson, and Jo Spencer
2360-2366
Conformation and Glycosylation of a Megalin Fragment Correlate with Nephritogenicity in Heymann Nephritis Alfonso Tramontano and Sudesh P. Makker
2367-2373
FcRI-ITAM Is Differentially Required for Mast Cell Function In Vivo Daiju Sakurai, Sho Yamasaki, Kanako Arase, Seung Yong Park, Hisashi Arase, Akiyoshi Konno, and Takashi Saito
2374-2381
The Crystal Structure of Human CD1b with a Bound Bacterial Glycolipid Thil Batuwangala, Dawn Shepherd, Stephan D. Gadola, Kevin J. C. Gibson, Nathan R. Zaccai, Alan R. Fersht, Gurdyal S. Besra, Vincenzo Cerundolo, and E. Yvonne Jones
2382-2388
Activation/Division of Lymphocytes Results in Increased Levels of Cytoplasmic Activation/Proliferation-Associated Protein-1: Prototype of a New Family of Proteins Brock Grill, Gary M. Wilson, Kai-Xin Zhang, Bin Wang, Regis Doyonnas, Manfredo Quadroni, and John W. Schrader
2389-2400
HOST DEFENSE Antibody-Dependent Cellular Cytotoxicity via Humoral Immune Epitope of Nef Protein Expressed on Cell Surface Takeshi Yamada, Nobukazu Watanabe, Tetsuya Nakamura, and Aikichi Iwamoto
2401-2406
Macrophages, CD4+ or CD8+ Cells Are Each Sufficient for Protection against Chlamydia pneumoniae Infection through their Ability to Secrete IFN- Antonio Gigliotti Rothfuchs, Maria Regina Kreuger, Hans Wigzell, and Martin E. Rottenberg
2407-2415
Calcium and Its Role in the Nuclear Translocation and Activation of Cytosolic Phospholipase A2 in Cells Rendered Sensitive to TNF-Induced Apoptosis by Cycloheximide David W. Draper, Virginia G. Harris, Carolyn A. Culver, and Scott M. Laster
2416-2423
Peripheral CD4 T Cells Rapidly Accumulate at the Host:Parasite 2424-2430
Interface during an Inflammatory Th2 Memory Response Motoko Morimoto, Masahiro Morimoto, Jeannette Whitmire, Shiyun Xiao, Robert M. Anthony, Hiroshi Mirakami, Robert A. Star, Joseph F. Urban, Jr, and William C. Gause Haemophilus influenzae Type b-Outer Membrane Protein Complex Glycoconjugate Vaccine Induces Cytokine Production by Engaging Human Toll-Like Receptor 2 (TLR2) and Requires the Presence of TLR2 for Optimal Immunogenicity Eicke Latz, Jennifer Franko, Douglas T. Golenbock, and John R. Schreiber
2431-2438
Parasite Antigen-Driven Basophils Are a Major Source of IL-4 in Human Filarial Infections Edward Mitre, Rebekah T. Taylor, Joseph Kubofcik, and Thomas B. Nutman
2439-2445
The Zinc Finger Mutation C417R of I-B Kinase Impairs Lipopolysaccharide- and TNF-Mediated NF-B Activation through Inhibiting Phosphorylation of the I-B Kinase Activation Loop Fan Yang, Junro Yamashita, Eric Tang, Hom-lay Wang, Kunliang Guan, and Cun-Yu Wang
2446-2452
Recognition of Homo- and Heterosubtypic Variants of Influenza A Viruses by Human CD8+ T Lymphocytes Adrianus C. M. Boon, Gerrie de Mutsert, Debbie van Baarle, Derek J. Smith, Alan S. Lapedes, Ron A. M. Fouchier, Kees Sintnicolaas, Albert D. M. E. Osterhaus, and Guus F. Rimmelzwaan
2453-2460
Protective Immunization against Group B Meningococci Using Anti-Idiotypic Mimics of the Capsular Polysaccharide Concetta Beninati, Simona Arseni, Giuseppe Mancuso, Walter Magliani, Stefania Conti, Angelina Midiri, Carmelo Biondo, Luciano Polonelli, and Giuseppe Teti
2461-2468
Cyclooxygenase-2-Mediated Prostaglandin E2 Production in Mesenteric Lymph Nodes and in Cultured Macrophages and Dendritic Cells after Infection with Salmonella Christal C. Bowman and Kenneth L. Bost
2469-2475
HIV-1-Specific Memory CD4+ T Cells Are Phenotypically Less Mature Than Cytomegalovirus-Specific Memory CD4+ T Cells Feng Yun Yue, Colin M. Kovacs, Rowena C. Dimayuga, Paul Parks, and Mario A. Ostrowski
2476-2486
Protective T Cell Immunity against Malaria Liver Stage after Vaccination with Live Sporozoites under Chloroquine Treatment Elodie Belnoue, Fabio T. M. Costa, Tobias Frankenberg, Ana Margarida Vigário, Tatiana Voza, Nicolas Leroy, Mauricio M. Rodrigues, Irène Landau, Georges Snounou, and Laurent Rénia
2487-2495
Liver Dendritic Cells Present Bacterial Antigens and Produce Cytokines upon Salmonella Encounter Cecilia Johansson and Mary Jo Wick
2496-2503
INFLAMMATION Suppression of Osteoprotegerin Expression by Prostaglandin E2 Is Crucially Involved in Lipopolysaccharide-Induced Osteoclast Formation Koji Suda, Nobuyuki Udagawa, Nobuaki Sato, Masamichi Takami, Kanami Itoh, Je-Tae Woo, Naoyuki Takahashi, and Kazuo Nagai
2504-2510
TNF Receptor Signaling Contributes to Chemokine Secretion, Inflammation, and Respiratory Deficits during Pneumocystis Pneumonia Terry W. Wright, Gloria S. Pryhuber, Patricia R. Chess, Zhengdong Wang, Robert H. Notter, and Francis Gigliotti
2511-2521
Involvement of Reactive Oxygen Species in Toll-Like Receptor 4-Dependent Activation of NF-B Karim Asehnoune, Derek Strassheim, Sanchayita Mitra, Jae Yeol Kim, and Edward Abraham
2522-2529
B7-DC Regulates Asthmatic Response by an IFN--Dependent Mechanism Koichiro Matsumoto, Hiromasa Inoue, Takako Nakano, Miyuki Tsuda, Yuki Yoshiura, Satoru Fukuyama, Fumihiko Tsushima, Tomoaki Hoshino, Hisamichi Aizawa, Hisaya Akiba, Drew Pardoll, Nobuyuki Hara, Hideo Yagita, Miyuki Azuma, and Yoichi Nakanishi
2530-2541
Role of Bradykinin B2 and B1 Receptors in the Local, Remote, and Systemic Inflammatory Responses That Follow Intestinal Ischemia and Reperfusion Injury Danielle G. Souza, Eliane S. L. Lomez, Vanessa Pinho, João Bosco Pesquero, Michael Bader, Jorge Luís Pesquero, and Mauro M. Teixeira
2542-2548
Contribution of Antigen-Primed CD8+ T Cells to the Development of Airway Hyperresponsiveness and Inflammation Is Associated with IL-13 Nobuaki Miyahara, Katsuyuki Takeda, Taku Kodama, Anthony Joetham, Christian Taube, Jung-Won Park, Satoko Miyahara, Annette Balhorn, Azzeddine Dakhama, and Erwin W. Gelfand
2549-2558
Microtubule-Associated Serine/Threonine Kinase-205 kDa and Fc Receptor Control IL-12 p40 Synthesis and NF-B Activation Hui Zhou, Huabao Xiong, Hongxing Li, Scott E. Plevy, Paul D. Walden, Massimo Sassaroli, Glenn D. Prestwich, and Jay C. Unkeless
2559-2568
Inhibition of c-Jun NH2-Terminal Kinase Activity Improves Ischemia/Reperfusion Injury in Rat Lungs Makoto Ishii, Yukio Suzuki, Kei Takeshita, Naoki Miyao, Hiroyasu Kudo, Rika Hiraoka, Kazumi Nishio, Nagato Sato, Katsuhiko Naoki, Takuya Aoki, and Kazuhiro Yamaguchi
2569-2577
Peptide-Mediated Inhibition of Neutrophil Transmigration by Blocking CD47 Interactions with Signal Regulatory Protein Yuan Liu, Miriam B. O’Connor, Kenneth J. Mandell, Ke Zen, Axel Ullrich, Hans-Jörg Bühring, and Charles A. Parkos
2578-2585
Matrix Metalloproteinase-9 Deficiency Results in Enhanced Allergen-Induced Airway Inflammation Sarah J. McMillan, Jennifer Kearley, J. Darren Campbell, Xing-Wu Zhu, Karen Y. Larbi, J. Michael Shipley, Robert M. Senior, Sussan Nourshargh, and Clare M. Lloyd
2586-2594
Inflammatory Gene Profiles in Gastric Mucosa during Helicobacter pylori Infection in Humans Sicheng Wen, Christian P. Felley, Hanifa Bouzourene, Mark Reimers, Pierre Michetti, and Qiang Pan-Hammarström
2595-2606
Key Roles of CD4+ T Cells and IFN- in the Development of Abdominal Aortic Aneurysms in a Murine Model Wanfen Xiong, Yong Zhao, Amy Prall, Timothy C. Greiner, and B.
2607-2612
Timothy Baxter Inhibition of IL-10 Receptor Function in Alveolar Macrophages by Toll-Like Receptor Agonists Stefan Fernandez, Purnima Jose, Margarita G. Avdiushko, Alan M. Kaplan, and Donald A. Cohen
2613-2620
Construction of Hevein (Hev b 6.02) with Reduced Allergenicity for Immunotherapy of Latex Allergy by Comutation of Six Amino Acid Residues on the Conformational IgE Epitopes Piia Karisola, Jari Mikkola, Nisse Kalkkinen, Kari J. Airenne, Olli H. Laitinen, Susanna Repo, Olli T. Pentikäinen, Timo Reunala, Kristiina Turjanmaa, Mark S. Johnson, Timo Palosuo, Markku S. Kulomaa, and Harri Alenius
2621-2628
Role of Toll-Like Receptor 4 in Endotoxin-Induced Acute Renal Failure Patrick N. Cunningham, Ying Wang, Rongqing Guo, Gang He, and Richard J. Quigg
2629-2635
CLINICAL IMMUNOLOGY Respective Roles of Decay-Accelerating Factor and CD59 in Circumventing Glomerular Injury in Acute Nephrotoxic Serum Nephritis Feng Lin, David J. Salant, Howard Meyerson, Steven Emancipator, B. Paul Morgan, and M. Edward Medof
2636-2642
TNF- Coupled to Membrane of Apoptotic Cells Favors the Cross-Priming to Melanoma Antigens Valérie S. Zimmermann, Attilio Bondanza, Antonella Monno, Patrizia Rovere-Querini, Angelo Corti, and Angelo A. Manfredi
2643-2650
A Spontaneous Model for Autoimmune Myocarditis Using the Human MHC Molecule HLA-DQ8 Jacqueline A. Taylor, Evis Havari, Marcia F. McInerney, Roderick Bronson, Kai W. Wucherpfennig, and Myra A. Lipes
2651-2658
In Vivo Evidence That Peptide Vaccination Can Induce HLA-DR-Restricted CD4+ T Cells Reactive to a Class I Tumor Peptide Mamoru Harada, Rumi Gohara, Satoko Matsueda, Akira Muto, Tatsuya Oda, Yoshiko Iwamoto, and Kyogo Itoh
2659-2667
Pulmonary Edema Fluid from Patients with Early Lung Injury Stimulates Fibroblast Proliferation through IL-1-Induced IL-6 Expression Mitchell A. Olman, Kimberly E. White, Lorraine B. Ware, Warren L. Simmons, Etty N. Benveniste, Sha Zhu, Jerome Pugin, and Michael A. Matthay
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CD40 Ligand Dysregulation in HIV Infection: HIV Glycoprotein 120 Inhibits Signaling Cascades Upstream of CD40 Ligand Transcription Rui Zhang, Carl J. Fichtenbaum, David A. Hildeman, Jeffrey D. Lifson, and Claire Chougnet
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HIV-1 Does Not Provoke Alteration of Cytokine Gene Expression in Lymphoid Tissue after Acute Infection Ex Vivo Annette Audigé, Erika Schlaepfer, Athos Bonanomi, Helene Joller, Marlyse C. Knuchel, Markus Weber, David Nadal, and Roberto F. Speck
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Breakdown of Tolerance to a Self-Peptide of Acetylcholine Receptor -Subunit Induces Experimental Myasthenia Gravis in Rats
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Fulvio Baggi, Andrea Annoni, Federica Ubiali, Monica Milani, Renato Longhi, Widmer Scaioli, Ferdinando Cornelio, Renato Mantegazza, and Carlo Antozzi CORRECTIONS Molecular Cloning and Immunologic Characterization of a Novel cDNA Coding for Progesterone-Induced Blocking Factor Beata Polgar, Gyula Kispal, Margit Lachmann, Gabriella Paar, Eszter Nagy, Peter Csere, Eva Miko, Laszlo Szereday, Peter Varga, and Julia Szekeres-Bartho
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The Cationic Antimicrobial Peptide LL-37 Modulates Dendritic Cell Differentiation and Dendritic Cell-Induced T Cell Polarization Donald J. Davidson, Andrew J. Currie, Gregor S. D. Reid, Dawn M. E. Bowdish, Kelly L. MacDonald, Rebecca C. Ma, Robert E. W. Hancock, and David P. Speert
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