Jordan University of Science and TechnologyFaculty of pharmacy

Department of medicinal Chemistry and PharmacognosySecond Semester 2015/2016

Course Syllabus

Course InformationCourse Title Pharmaceutical Analytical Chemistry

Course Code Phar 225

Prerequisites General Chemistry II (Chem 102)

Course Website

Instructor Dr. Fawzia M.J.Redha, Prof. Adnan M. Massadeh & Dr. Aref ZayedOffice Location P1 - L4

Office Phone # 23543 & 23545

Office Hours Sunday 11:00-12:00, Monday 8:30-9:30, Wednesday 12:30-1:30, Thursday10:00-11 :00.

E-mail faxx@just. edu. j 0, massadeh@just. edu. j 0 , alzayed@just edu. jo

Teaching NoneAssistant(s)

Course Aims and ObjectivesThe aim of this course is to explain the fundamental analytical methods of analysis including thetheoretical background and the calculations needed with their applications in pharmaceutical analysis.The conventional analytical methods are discussed in this course with the relative terms used and all themathematical calculations required including the statistical evaluation of the analytical data obtained andas it is required by the official methods of analysis stated in the Pharmacopoeias.

Course Objectives1) to set up good knowledge about the fundamental pharmaceutical methods of analysis applied in

all pharmaceutical analytical laboratories.2) To introduce and discuss in details the main conventional methods used in pharmaceutical

assays.3) To understand all the analytical terms & expressions used in pharmaceutical analytical methods4) To interpret and evaluate all the results and data obtained.5) To learn about all types of chemical reactions and the mathematical steps involved in

quantitative analytical methods.6) To obtain information about the Pharmacopoeias and their uses in pharmaceutical labs.

Course Description

The fundamental analytical methods are explained in this course with all the theoretical basis & basiccalculations applied in conventional analytical methods of analysis used in pharmaceutical laboratories.The chemical equilibrium & the Henderson-Hasselbalch's equation, acid-base titrations and non-aqueous titration methods used in pharmaceutical analysis are discussed in this course in addition to theofficial quantitative methods required in the Pharmacopoeia for pharmaceutical compounds.

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Textbook & ReferencesTitle Analytical Chemistry

Author(s) G. Christian

Publisher John Wiley &Sons, Inc., New York

Year 2006

Edition 6th. Ed.

Book WebsiteOther references 1. A. H. Beckett and J. B. Stenlake: Practical Pharmaceutical Analysis,

4th ed., Part (I), The Athlone Press, London, 1988.

2. Lectures handouts.

Intended Student Learning Outcomes (ISLOs)Upon successful completion of this course, students should be able to:

Set up principles of conventional analytical methodsIdentify all the requirements for quantitative analysis

Have good mathematical skills in expressing the results obtainedSolve analytical problems related to the quantity of an unknown & the purity of samples

Interpret the data obtained & evaluate the results using statistical methodsDeal the official methods of analysis as required by the Pharmacopoeias

Teachin~ & Learnin~ Methods

The student should be able to understand the given lectures & the assignedrelated chapters in the text book. The student should be able to understandthe chemical reactions with the related mathematical procedures used to givethe solution to the analytical problem in addition to be able to evaluate theresults using the relevant statistical methods and equations.1. Overview the lectures using the data show provided with the overhead projector.

2. Illustrate the importance concepts on the board.

3. Solve the problems that are related to the course.

4. Discuss and ask the students some question in order to activate the lecture by participating the studentsto answer the questions.

5. Give a summary for the lecture.

6. Encourage the students to prepare an assignment related to the course using the internet.

7. Encourage the student to ask any question during the office hours or any time if possible .

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AssessmentAssessment Expected Due Date Percentage

First Exam 28th March, 2016 30%

Second Exam 2nd May, 2016 30%

Final Exam 21st May, 2016 40%

Assignments --------

Participation --------

Attendance ---------

Learning Outcomes: Upon successful completion of this course, students will be able toRelated Objective(s) . . Reference(s)

1) To provide a strong background in chemical principles that are important in Chapter 2 and

analytical chemistry. handouts

2) To show the importance of application of statistical methods in analytical Chapter 2 andchemistry. handouts

3) To introduce a wide range of techniques that are useful in modern analytical Chapter 3, 4, 6, 7methods. and handouts

4) To develop the skills needed to solve analytical problems in a quantitative Chapter 4, 6, 7 andmanner. handouts

5) To teach the students the laboratory skills that will give students confidence in Chapter 1 & 2 and

their ability to obtain high quality analytical data. handouts

6) To show the importance of analytical chemistry in agriculture, medicine, industry

and other aspects in our life.

Course ContentWeek

Topics Chapter in Textbook(handouts)

1-2 1- An Introduction to Analytical Chemistry

a. Definition and Basic Conceptsb. The Analytical Processc. Choice of Analytical Methods forPharmaceutical Analysis

2 11- Errors in Analysis and evaluation inChemical and Evaluation of Analytical Data

a. significant Figuresb. Types of Errorsc. The Mean, Mediand. Standard Deviation, Standard Error of TheMeane. Variance, F-test, Confidence Limitsf. Significant tests (f-test, t-test, Q-test)

111- Overview of Some Analytical Methods:Titrimetric Methods of Analysis

a. Acid-Base Titrationb. Precipitation Titrationc. Oxidation-Reduction Titrationsd. Compleximetric Titrationse. Gravimetric Methods of Analysis

IV- Chemical Equlibria, Buffers and Acid-Base Titration Methods.a. Buffer Solution and Physiological Bufferb. Acid-Base Equilibriac. Titration Curvesd. Non Aqueous Solvents Titrationse. Aoolications in oharmaceutical analyses.V- Pharmaceutical Analysis and QualityControl

a. Pharmaceutical Analysis and Quality Controlb. The official Methods of Analysis

~ I c. The Pharmacopoeias

Additional NotesExams • The format for the exams is generally (but NOT always) as follows: Multiple-choice

and short essay questions.

• Grades will not be given out via e-mail.

Makeup • Makeup exam should not be give unless there is a valid excuse .Exams • Arrangements to take an exam at a time different than the one scheduled MUST be

made prior to the schedules exam time.

Drop Date • Last day to drop the course is before the twelve (1ih) week of the current semester.

Cheating The commitment of the acts of cheating and deceit such as copying duringexaminations, altering examinations for re-grade, plagiarism of homework assignments, andin any way representing the work of others as your own is dishonest and will not be tolerated.Standard JUST policy will be applied

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Attendance • Excellent attendance is expected .

• JUST policy requires the faculty member to assign ZERO grade (35) if a studentmisses 10% of the classes that are not excused

• If you miss class, it is your responsibility to find out about any announcement orassignments you may have missed.

Workload • Average work-load student should expect to spend is 6 hours/week.

Graded exams • Instructor should return exam papers graded to students not after the week after theexam date.