Di�erent choices. Di�erent results.

*Double-blinded quantitative market research study comparing patient and surgeon experience with DERMABOND PRINEO System and skin staples in total knee arthroplasty.

N=88 patients. N=83 orthopaedic surgeons. 90% c.I. Fielded June/July 2017.

The surgeon- and patient-preferred alternative to staples*1

First knee surgeryMy doctor usedstaples on my incision

Second knee surgeryMy doctor used DERMABOND® PRINEO®Skin Closure System

You have options for your joint replacement surgery.

For illustrative purposes only to show results approximately1-2 years post surgery. Individual results may vary.

How DERMABOND PRINEO System works

Instead of skin staples, a lightweight mesh is applied over your incision, then coated with a liquid skin adhesive to form a strong, flexible seal.2,4,5

Unlike staples which can be painful to remove, DERMABOND PRINEO System falls o� naturally in two weeks or less.2

STRO

NG, FLEXIBLE SEAL

BLO

CKS WATER & BACTERIA

Your recovery starts with DERMABOND® PRINEO® Skin Closure System

No waiting to shower2*

No train track scar1

No staple holes2,3

No bandages required2,3

No painful staple removal— falls o� naturally in 7–14 days2

Why go home with skin staples if you don’t have to?

†Clinical significance unknown.‡Double-blinded quantitative market research study comparing patient and surgeon experience with DERMABOND PRINEO System and skin staples in total knee arthroplasty. N=88 patients. N=83 orthopaedic surgeons. 90% c.I. Fielded June/July 2017.

Creates a watertight seal, creating a barrier to water and bacteria entering the wound.2,5

Demonstrated in vitro to kill 99.9% of bacteria (MRSA, MRSE, and E. coli) on direct contact.6†

You can shower immediately after surgery if your healthcare professional says it's okay.2

Since bandages aren't required, it's easier tocare for your incision.2,3

Patients with DERMABOND PRINEO System agreed that they were more satisfied with the appearance of their incision compared to skin staples1‡

*If directed by your physician.

With easier aftercare and fewer concerns about wound complications, you'll feel like your pre-surgery self in no time.2,3,6,7

Choose the ideal wayto heal with DERMABOND PRINEO System

“During the past two years, I have been using [DERMABOND PRINEO System], and it is a top-notch product. I am always completely satisfied because my patients are completely satisfied."

– Siripong Ratanachai, M.D., Orthopedics Bumrungrad International Hospital - Bangkok, Thailand

"Imagine the convenience, comfort and confidence of allowing our patients to take a regular bath early on andgo about their daily routine without having to worry about wound care and risk of wound contamination... that's patient care at its finest.”

– Jose Antonio G. San Juan, M.D., Arthroscopic Surgery & Sports Medicine;Joint Replacement Surgery

Orthopedic Consultant - Chong Hua Hospital, Cebu, Philippines

©2019 Ethicon US, LLC. All rights reserved. 123154-190912

DERMABOND PRINEO Skin Closure System is for topical use in easily approximated skin wounds and carries risks common to topical skin adhesive systems. These risks may include infection, acute inflammation, skin edge separations, excessive itching and skin blistering. These risks should be discussed in detail with your doctor. DERMABOND PRINEO System is not indicated for patients with a known hypersensitivity to cyanoacrylate, formaldehyde, benzalkonium chloride or pressure sensitive adhesive. Only your doctor can advise you whether the benefits of this procedure outweigh the risks in your situation and whether DERMABOND PRINEO System and the procedure are right for you. The success of this procedure depends on many factors, including your physical condition, your body’s ability to tolerate the procedure and its responses to the device. Use care in the selection of your doctors and hospital, based on their skill and experience. Ask your doctor for more detailed information about this device or call 1-877-ETHICON (384-4426), and discuss this information with your doctor.

For complete indications, contraindications, warnings, precautions, and adverse reactions, please reference full package insert.

Ask your doctor about DERMABOND® PRINEO® Skin Closure System today!

Quote is the opinion of Dr. San Juan, a real surgeon who used DERMABOND PRINEO System. Post-surgical interview was September 1, 2019.

Quote is the opinion of Dr. Ratanachai, a real surgeon who used DERMABOND PRINEO System. Post-surgical interview was September 10, 2019.

Quote is the opinion of Dr. Kissin, a real surgeon who used DERMABOND PRINEO System. Post-surgical interview was Nov 28, 2017.

“One of the main advantages of using [DERMABOND PRINEO System] is reduced wound care.”

- Dr. Yair Kissin, Orthopaedic SurgeonHackensack University Medical Center - Hackensack, NJ

References: 1. PRINEO Claims Research Quant Detail. August 16, 2017. Ethicon, Inc. 2. DERMABOND® PRINEO® Skin Closure System. Instructions for Use. Ethicon, Inc. 3. De Cock E, van Nooten F, Mueller K, Tan R. Changing the surgical wound closure management pathway: time and supplies with PRINEO vs. standard of care for abdominoplasty surgery in Germany. Poster presented at: International Society for Pharmacoeconomics and Outcomes Research, 11th Annual European Congress: November 2008; Athens, Greece. 4. Kumar, A. AST-2012-0290 Study to compare the tissue holding strength of PRINEO™ skin closure system with conventional wound closure techniques. October 11, 2012. Ethicon, Inc. 5. Kumar A. AST-2014-0060 Completion Report for Design Verification testing for DERMABOND™ PRINEO™ 22 cm skin closure system (DP22) AST-2014-0060 Version 2. April 19, 2016. Ethicon, Inc. 6. Bhende S. In-vitro study to evaluate the ability of DERMABOND™ PRINEO™ Skin Closure System to kill bacteria on contact. June 22, 2012. Ethicon, Inc.