JohnChung Metoprolol-IVIVC-PBPK AAPS 2008 poster … · IVIVC is to develop a correlation or...

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Transcript of JohnChung Metoprolol-IVIVC-PBPK AAPS 2008 poster … · IVIVC is to develop a correlation or...

Page 1: JohnChung Metoprolol-IVIVC-PBPK AAPS 2008 poster … · IVIVC is to develop a correlation or relationship between the in vitro release and in vivo release of a formulation so that

Method Ivivc

Method Ivivc

THE EXPANDING IVIVC TOOLBOX TO ENABLE DRUG …THE EXPANDING IVIVC TOOLBOX TO ENABLE DRUG PRODUCT QUALITY COMPLEMENTARY TRADITIONAL AND PBPK BASED APPROACHES Filippos Kesisoglou, PhD,

THE EXPANDING IVIVC TOOLBOX TO ENABLE DRUG …THE EXPANDING IVIVC TOOLBOX TO ENABLE DRUG PRODUCT QUALITY COMPLEMENTARY TRADITIONAL AND PBPK BASED APPROACHES Filippos Kesisoglou, PhD,

PBPK MODELING OF DRUGS METABOLIZED VIA SEVERAL

PBPK MODELING OF DRUGS METABOLIZED VIA SEVERAL

IVIVC topical dosage form

IVIVC topical dosage form

Factors Affecting IVIVC - PharmaQuesTpharmaquest.weebly.com/uploads/9/9/4/2/9942916/ivivc.pdf · Factors Affecting IVIVC Factors Affecting Development of a predictable IVIVC 1. Physicochemical

Factors Affecting IVIVC - PharmaQuesTpharmaquest.weebly.com/uploads/9/9/4/2/9942916/ivivc.pdf · Factors Affecting IVIVC Factors Affecting Development of a predictable IVIVC 1. Physicochemical

Dissolution for specific products Role of IVIVC...•Key points in level A IVIVC for long acting drugs oIn vivo release can be mustiphasic implying more than one mechanism of action

Dissolution for specific products Role of IVIVC...•Key points in level A IVIVC for long acting drugs oIn vivo release can be mustiphasic implying more than one mechanism of action

Use of Physiologically Based Pharmacokinetic (PBPK ...

Use of Physiologically Based Pharmacokinetic (PBPK ...

PHYSIOLOGICALLY-BASED PHARMACOKINETIC (PBPK) MODELING …download.e-bookshelf.de/download/0000/5919/63/L-G-0000591963... · Physiologically-based pharmacokinetic (PBPK) modeling and

PHYSIOLOGICALLY-BASED PHARMACOKINETIC (PBPK) MODELING …download.e-bookshelf.de/download/0000/5919/63/L-G-0000591963... · Physiologically-based pharmacokinetic (PBPK) modeling and

u i v a lence Bi Sakore and Chakraborty, J Bioequiv ......In Vitro–In Vivo Correlation (IVIVC): A Strategic Tool in Drug ... Levels of Ivivc There are four levels of IVIVC that have

u i v a lence Bi Sakore and Chakraborty, J Bioequiv ......In Vitro–In Vivo Correlation (IVIVC): A Strategic Tool in Drug ... Levels of Ivivc There are four levels of IVIVC that have

Exploring Mechanistic Toxicity of Mixtures Using PBPK ...

Exploring Mechanistic Toxicity of Mixtures Using PBPK ...

Anemia Neonatus PBPK

Anemia Neonatus PBPK

Physiologically Based Pharmacokinetic (PBPK) Modeling of ... · Physiologically Based Pharmacokinetic (PBPK) Modeling of Benzene in Humans: A Bayesian Approach Karen Yokley*, Hien

Physiologically Based Pharmacokinetic (PBPK) Modeling of ... · Physiologically Based Pharmacokinetic (PBPK) Modeling of Benzene in Humans: A Bayesian Approach Karen Yokley*, Hien

IMPORTANCE OF IVIVC AND METHODS OF ESTABLISHING …pharmaquest.weebly.com/Uploads/9/9/4/2/9942916/Method_ivivc.pdfIMPORTANCE OF IVIVC AND METHODS OF ESTABLISHING IVIVC 1. INTRODUCTION

IMPORTANCE OF IVIVC AND METHODS OF ESTABLISHING …pharmaquest.weebly.com/Uploads/9/9/4/2/9942916/Method_ivivc.pdfIMPORTANCE OF IVIVC AND METHODS OF ESTABLISHING IVIVC 1. INTRODUCTION

day seminar on “Particle Size Measurement and Basics IVIVC‟‟.

day seminar on “Particle Size Measurement and Basics IVIVC‟‟.

Approaches to IVIVC Development for Regulatory Success · Safeguarding public health Approaches to IVIVC Development for Regulatory Success PharmSci 2012 12th - 14th September 2012

Approaches to IVIVC Development for Regulatory Success · Safeguarding public health Approaches to IVIVC Development for Regulatory Success PharmSci 2012 12th - 14th September 2012

Ivivc sahilhusen

Ivivc sahilhusen

IVIVC Toolkit™ User’s Guide

IVIVC Toolkit™ User’s Guide

IVIVC Industry Perspective with Illustrative Examples › wp-content › uploads › 2015 › 08 › pdf › Li.pdf · IVIVC Industry Perspective with Illustrative Examples Presenter:

IVIVC Industry Perspective with Illustrative Examples › wp-content › uploads › 2015 › 08 › pdf › Li.pdf · IVIVC Industry Perspective with Illustrative Examples Presenter:

Conventional versus Physiologically-Based (PB)-IVIVC ... · Conventional versus Physiologically-Based (PB)-IVIVC: Revisiting Some Successful and Failed Conventional IVIVC Cases with

Conventional versus Physiologically-Based (PB)-IVIVC ... · Conventional versus Physiologically-Based (PB)-IVIVC: Revisiting Some Successful and Failed Conventional IVIVC Cases with

Dissolution / Biowaivers / IVIVC - bebac.atbebac.at/lectures/Kaunas2017-9.pdf · Bioequivalence, Dissolution & IVIVC. Vienna, 12–14 June, 2017. Training on Bioequivalence | Kaunas,

Dissolution / Biowaivers / IVIVC - bebac.atbebac.at/lectures/Kaunas2017-9.pdf · Bioequivalence, Dissolution & IVIVC. Vienna, 12–14 June, 2017. Training on Bioequivalence | Kaunas,