Jan 2009 by “N”

PHARMACIST1. Homeostasis as defined as ------ the body balance system2. In GLC, one of the phase is preferred ---------volatile (Gas) 3. Which if the following vit acting as a hormonea. Eb. B6c. D3d. A

4. TSH is secreted from a. hypothalamusb. anterior pituitaryc. posterior pituitaryd. adrenal medulla

5. All of the following hormones secreted from anterior pituitary EXCEPTa) FSHb) LHc) ACTHd) ADH

6. Which of the following does not secrets in duodenuma. Mucus cell secretionb. Pancreas secretionc. Liver secretiond. Gall bladder secretion

7. Define Angiogenosis------ Formation of new blood vessels

8. warfarin site of action is ------Liver9. Normally existed in blooda. prothrombinb. thrombinc. fibrin

10. The most effected cells with antineoplastic drugsa. neutrophilsb. lymphocytesc. platelets

11. First cells on the site of inflammation are a. basophilb. neutrophilc. platelets

12. DOC for coagulation in pregnancya. heparinb. warfarinc. ASA

13. A patient with cystitis should be counselleda. use diaphragm ( women who use the diaphragm are prone to inflammation)b. void after sexc. drink a lot of water

14. Uric acid production ↓ by which druga. allopurinolb. probenecidc. uricosuric agent

14. pencilline are small t 1/2 due to a. great protein binding b. active tubule secretionc. hydrolysis

15. Haemorrhoid patient can be advise to a. ↓ fiber dietb. Avoid prolong sitting timec. Avoid straining in toilet

16. poison IV which is not good advicea. loratadineb. epinephrine

17. sildenafil(PDE -5 inhibitor with nitrates do all EXCEPT

a. hypertensive crisisb. hypotension c. erectile disfunctioning

18. Prazosin do all EXCEPTa. Orthostatic hypotensionb. Hypertension crisis

19. Prazosin is a. α1 antagonistb. α 2 agonistc. β1 antagonistd. β2 agonist

20. The antidepressant work on epinephrine & dopamine, 5HT→

Dual action (SNRI’S, SNDRI’S)

21. Which antidepressant should be avoided when ↑ weight is undesirable

a. Mirtazapineb. Trazodonec. Bupropiond. Amitriptyline

22. What is the best treatment of uncomplicated diaper rash → ZnO

23. Poriasis is → Silvery white and red patches that form scales

24. Steven Johnso(

a. rashb. skin peeling

25. vertigo with meniers (infection of inner ear)disease -----

Gentamycin for vertigo, Low salt diet and Diuretics (Acetazolamide)

26. streptococcal meningitis is best treated with --------- Ampicillin + Gentamycin

27. All of them are used for HIV EXCEPTa. Efavirenzb. Trizivirc. Tenofovird. Acyclovir

28. Traponema pallidum----------- chancre(Ulceration in early stage of syphilis) & syphilis_

29. Which drug ↓ mortality in heart failurea. Enapri;b. Captoprilc. Digixond. Amlodipinee. Propranolol

30. In prinzmetalm agina all of them are good choice EXCEPTa. CCBb. BBsc. ACEId. Nitrates

31. Which is not a risk factor in Iron deficiency anaemiaa. Pregnancyb. Gastric refluxc. Peptic ulcerd. Haemorrhagee. Surgery

32. Which is not risk factor in hyper urecemia

a. hypertensionb. Obesityc. Pulmonary disease

Comments: Alcohol, atherosclerosis, diabetes, hyperlipidemia and hypertension, obesity, renal disease are among the risk factors of hyper urecemia

33. Define Ascitis ------ accumulation of fluid in peritoneal cavity

34. Evidence that DM exist , what blood glucose rate in fasting should be a. 5.2mmol/L – 7.1mmol/Lb. 7.1mmol/L -11.1mmol/Lc. 8.5mmol/L - 10.0mmol/Ld. 10.0mmol/L – 12.1mmol/L

35. which structure is best used in lipid parenteral injectionsa. CMCb. Cholesterolc. Phospholipids

36. Aluminium Acetate is used as ------burrow’s solution

37. All of them are important in plasmid EXCEPTa. DNAb. Bacteriac. Eukaryoticd. Ligasee. Restriction enzymes

38. Acetominophen prolonge used will effect ------ hepatoxicity

39. Defroxamine mechanism , site of action with Fe + ----- chelating

40. Aromatic and chealting ------------- penicillamine

41. mouth ulcer is the S.E of methotraxate treated by → folic acid

42. Major enzyme involved in the metabolism of drug → CYP 3A4

43. Structure of which enzymes with acetaminophen ------ Glutathione conjugation

44. Glutathione consists -------------- Cystein, Glycein , Glutamic acid

45. Which substance directly protects cell integrity ----------- Vit. E , Glutathione

46. Excipient that may cause diarrhea -------- Mg Stearate

47. Which subs may induce diarrhea----------mg stearate

48. Megaloblastic anemia is due to deficiency ------------ folic acid

49. Incorrect regarding Hcl EXCEPT

a. kill bacteriab. Kills C.difficle (anaerobic)

50. Fe absorption can be ↑ by Vit.C

51. Nystatin (antifungal for diaper rassh) ergosterol associated with --------------- cell lysis52. Phenols are most likely metabolised ------ Glucoronidation

53. Which is not a Phase II reaction ---a. sulfoxidationb. N-acetylation

54. Which of these condition antithyroid drug is used for a. Grave diseaseb. cretinismc. myxedema

55. A physician in a unit dose hospital writes for Prednisone 15mg tid, each package contain 1 x 5mg tablets. How many package are needed per dose-------------------- if 1 pack 5mg then 3 pack contain 15mg, ----------- Ans : 3

56. A physician in a unit dose hospital writes for Prednisone 15mg tid, each package contain 1 x 5mg tablets. How many package are needed per day--------------------- if 1 pack is 5mg then 3 pack contain 15mg and for 3 days , 3 x 3 = 9Ans, ie 3pack in the morning , 3 pack in the noon and 3 pack in the evening

57. Prolong use of which drug may cause thrombocytopenia------- ibuprofen adverse effect NOT good for heart patient

58. Which drug may cause GI problem--------- Indomethacin

59. Cox II inhibitor is least likely cause -------- GI problem

60. Tubular reabsorption of weak base ---- what is NOT factor a. PH of urineb. pka of drugc. rate flow of urined. metabolisme. lipid solubility

61. Define hypertrophy------ enlargement of organ OR Tissue

62. Gout patient which drug is NOT preferred-------------acetominophan (NSAID)

63. One with milk allergy is allergic to what-----a. proteinb. lactose

64. Which of the following is ARR--------

65. On a long flight what should be counsela. Don’t drink tap waterb. Don’t eat large mealsc. Dimenhydrinate is effective in motion sickness

66. Emesis resulted from Narcotic is due to a. Direct effect on GIb. Stimulation of CTZ

67. Which opioid receptors are involved in paina. meu

68. Chemistry of one of Ach analogue can inhibitor with enzyme------- Ach cholinesterase

69. structure of Purine analog

70. Esomeprazol & omeprazole relationship ----------------------- PPI’s

71. Cimetedine ---------------- not used in allergic reaction

72. Silver sulfasalazine ------what is in the structure that makes it not absorbable?

Azo Bond

73. What is substituted in penicillin that makes it long acting ------- amide group?

74. Cephalosporin structure---------------- CH2 -N I I CH2 C = O 75. SAR ( structure activity relationship) of ciprofloxacina. presence of F atomb. presence of CH2 group

also contain COOH group

76. nasal absorption what is wrong a. using of peptidesb. large surface increases systemic absorptionc. large volume need preservatives

77. Which is NOT a cranial bone

a. Frontalb. Ethmoidc. Occipitald. Sphenoide. Hyoid (Tongue bone)f. Maxial(face bone)

78. Which one of the following is a least emetogenic druga. cyclophosphamideb. doxirubicinec. tamoxifined. rosiglitazonee. bleomycin

79. Patient Not respond to drug what will you give

80. Urinary incontinency in women which is not effectivea. progesterone

b. Estrogen (also used)

c. oxybutin(Ist Line)d. impramine( in children)e. tolterodrine( Ist line)

81. Q about plan B82. About correct OCP way83. Regimen of plan B84. What is controlling the cerebral blood flowa. PCO2 ( Partial pressure of co2)

b. PO2

85. HCO3 is present in interstial fluid in higher conc ---------in plasma

86. Aminoglycoside are best to be taken in daily because → t 1/2 12 hours→ their MOA is unknownNote : post dose effect must be there

87.Clathromycin resemble with------------------Erthromycin

87. Drink a lot of water with a. sulfonamideb. alluporinal

88. Sufamethoxazole MOA---------- folate synthesis inhibitor

89. Cholesterol ------- chelate with which enzyme

a. aromatase

b. epoxidasec. hydroxilased.

90. Defination “DNA”

90. Correct sequence of DNA & RNA ↓ ↓ T U

91. The drug that produce LEAST hypokalemia ------ → spironolactone

92. Diarrhea in patient ---------------- due to Statins

93. Rhabdomyolysis or myopathy (muscle disease) is S.E of ---------------statins

94. Theophylline C.I with -------------------- Cimetedine

95. Drugs least affected by hepatic microsomal enzymes-------

a. Penicillinb. erythromycinc. ketoconazole

96. GABA MOA is ------------------------97. Whish one of the following is a essential amino acid

PTVTIMHALL

98. Primary protein is made up of amino acids linked by peptide bonds

99. Vit deficiency in smoker is----------------------- “C”

100. Dysopyramide MOA.......... Na ,< K

101. Status Epileptics treatment ------------------- IV Diazepam

102. Atropine ------------ophthalmic solution or suspension

103. hypertonic solution ---what is added to make it isotonica. waterb. Naclc. NaoHd. CH3

104. Metformin is C.I in all EXCEPT a. Renal failureb. Adjuvantc. Insulin & obese

Comment : Metformin is contraindicated in both renal and hepatic failure

105. rate limiting step in percutaneous absorption------ stratum corneaum

106. Structure of morphine what is important-----------P-Phenyl N-Alkyl moiety

Morphine Antagonist contains Ally Group

107. Rapid acting insulin , what is correct

Taken 15 min before meal

108. what is correct regarding human insulin subs by others a. dose adjustment should be done for regular insulin

109. What is not first line therapy for T.B

a. penicillinb. INH

110. Protein can be detected by

a. western Blotting

111. Asthma patient what is not useda. beta blockersb. bronchodilator

112. A terminally ill patient (liver disease) what is decreasea. clotting timeb. ASTc. ALTd. Albumine. Billirubin

113. What is true regarding COPDa. co morbidity with asthmab. linked significantly with cigarettesc. LABA & SABA is non –effectived. B-agonist is the same importance as in asthma

114. To reach CSS fast what characteristics of drug should be

t 1/2 & renal clearance and liver metabolism

115. Which of the following (monoclonal antibody) used in therapy of metastatic breast cancer

116. Herceptin (trastuzumab) is a. treatment of HER 2 –over expressing metastatic breast cancerb. Tumour necrosis factor alpha inhibitorc. Glycoprotein inhibitord. Interleukine. Interferon

\

117. ↓ ADH leads toa. Pyurea(pus in urine)b. thirstc. osmolarity?

Decreased osmolarity of plasma causes decrease release of ADH

Osmolarity is the measure of solute conc. Per litre.........ADH causes reabsorption of solute free water , hence the conc of solute increase in urine and decreases in plasma

118. DOC for pregnant in hypertensiona. methyldopa

119. DOC for pregnant in diabetesa. Insulin

120. Nicotine replace therapya. rotation of patchb. if sensitive to gum can use patches

121. All of them in type I DM EXCEPTa. Juvenile b. Obesityc. Keto acidosis

122. Which hepatitis can be chronic

B, C & D

123. treatment for hep “C” is a. interferon α

124. All of them are the S.E of clozapinea. agranulocytosis

125. Define lypholization----------- freez drug methods

126. P.O.S is ----------127. Best to asses inventory is ------------- turn over rate128. Negotiation between union and employer is a. bargainingb. debatec. argumentationd. arbitration

129. which is NOT important in vaccinationa. cleaning of handsb. cleaning of placec.

130. Abbreva (docosanol) is used for a. coughb. cold sore ( Topical Cream)c. decongestiond. allergye. rosacea

131. A patient with cystic acne ,what is the best treatment-------isotretinoin

132. Cholycystitis is ------------inflammation of bladder

133. premenopause with osteoprosis which is inappropriatea. Vit. Db. Estrogens

c. Raloxifen since it aggravates hot flushes so don’t start until menopause is established..................ONLY IN POST MENOPAUSE

d. Fosamax

135. if a drug is 150mg ---CSS is 19 , if 300mg CSS will be -----52

134. What is correct a. enzymes liver is saturatedb. albumin binding

135. what is saturated means

For drug induced Parkinson’s disease to treat Extra pyramidal symptoms

136. Ideal temp for suppositories is

a. 30Cb. 45 Cc. 60Cd. 15C

138. Cholestyramine ↓ which circulatory subs ------ All except Triglycerides139. Embolism Def------------ moving blood clot

140. Atherosclerosis Def ------------- ↓ blood flow in arteries due to deveopement of atherosclerotic plaques

141. Blood is transported to liver through ------------- portal vein

142. Vaccine of pneumococcal is required a. every yearb. every ten yearc. once a life

142. Tetanus vaccine needed every a. ten yearsb. every yearc. once a life

143. Diff between complicated and uncomplicated UTI can be recognized a. urgent need of urination b. turbid urine

144. Uncomplicated UTI sulfonc regimenis a. 1 Dayb. 3 days If Complicated then 10 DAYS Cotrimoxazolec. 10 daysd. 14 days

145. Turbohaler what is correcta. counselled for high dose drugb. sensitive to humidityc. one dose

146. Spacer used in turbohaler counsellinga. clean with wet tissueb. Not with water

147. Angle bwtween liquid and solid is described as a. Wet ability

148. Tonicity --------- what is wrong a. it can be measured by freezing point depression

Comments:

It is a colligative property

149. ↓ cortisone ,what disease --------------- Addison’s Disease150. Pilocarpine produce -----------------------------miosis151. Cycloplegia Definition ------------- pyralysis of eye muscles----ciliary muscles

caused by anticholinergics

152. Prophylatic therapy for endocarditis is required in all except a. previous exposed infectionb. substituted valvec. post M.I

153. One have sleep disorder you can advise all excepta. sleep time regularb. exercise before bedtimec. don’t sleep in the afternoon

154. Second application for anti lice shampoo is required because -----a. eggs leftb. new born leftc. not clear very well

155. DEET ------------------------------------------counselling

Avoid in eyes & mouth156. Topical therapy for alopecia-------Minoxidil

157. All of these required safe disposal EXCEPTa. needleb. syringec. lancetd. spatula

157. Abbreviation cc means----------- with food

158. OU means---------------------------------- both eyes159. ZnSO4 200mg displace with 50mg of coca butter base

160. In microcytic anaemia , what is wrong

a. reduce volume of cellb. increase serum ferritin coz it decreases

158. What include CBCa. Hematocritb. WBCc. RBC

159. Ca++ reabsorption occur in which part of nephrona. distal tubule\b. convulated tubulec. loop of henle

161. Inflammatory bowl disease --------------------crohn’s disease162. Peptic ulcer ---------------- h-pylori

163. Etiology Def----------causation

164. Large dose of antibiotic needed-----------

To overcome resistence

165. High dose from 50mg to 100mg

a. there will be ↑ in fraction of elimination drug / unit timeb. ↑ Vd

166. Diff between soft contact lense and gas rigidity lensa. less fragileb. high H2O content

167. Enzyme produce by bacteria ------ B- lactamase

168. Acid resistant penicillin is -----------cloxacillin it is also resistant to B-Lactamase

169. Which is a choice in therapy of -ve meningitis --------Penicillin G

170. Chemistry in structure of cortisone when C binds to O ----Hemiacetal

171. Precurser of vit D3 is --------- 7 dehydrocholestrol

172. Drug bound to ---acid Albumin

173. Drugs in O/W ---- partition coefficient ----- c of v = SD / X x 100

174. BMI = weight (in kg) / h ( in miter)

If a person weight is 60 kgAnd height is 6ft

1 Meter= 3.3 ftI ft = 12inch1 meter= 39.5 inch

BMI = 6ft x 12(inch) = 72 inch

180 / 100 = 1.8m

BMI = 60 / (1.8)2 = 60 / 3.24 = 18.51 Ans

Note : orlistat is only given when BMI is more than 30

175. Phase I ------ also called functional Group metabolism or Mixed function Oxidase Metabolism

176. Which is reverseable MAO-I -----meclobemide

177. Hemoglobin cannot carry O2 due to which reaction a. oxidationb. reductionc. 0d. 0

178. The plane that divide body into unequal left and right ----parasagital

179. Intra-thecal admin means ------------ In Spine

180. The particle of disperse phase have inherent stability, why? Becausea. small surface areb. high surface area

181. Levigating agent is ------- mineral oil

182. Zero order ---------- slope ---- k in C10 +10+10 +10 +10 zero order25+50+75+ half life

183. Absolut risk reduction is -------------ARR = EER --- CER

184. Competitive inhibitor-------------

185. What decrease in elderly -----------Body lean mass

186. Major difference between plasma and interstitial fluid

a. quantity of protein

187. 5 α reductase inhibitor ------finastride-----BPH

188. Monitoring of hypothyroidism ------ Serum TSH assay

189. Orlistat----------------------intestinal lipase inhibitor

190. Phenytoin S.E --------gingival hyperplasia

191. A drug designed as patch -

The shelf life t 1/2 is one year the researcher should do what is shelf life or t1/2 os over one year

192. Haploid is --------- No. of chromosomes of gemed , single set of chromosomes

Examples : sperm and ova

193. Which drug can not be use for chronic Spasticity ( multiple sclorisis)

a. Dantrolineb. Baclofen

c. Clonzepam

JANUARY 2009 (PART -2)

1. Angiogenesis means - Formation of blood vessels2. Hypertrophy means – Enlargement of cells by size rather

than increase in number of cell3. Cystitis means –bladder inflammation4. Sciatic nerve in all foot branch5. All branch of cerebral except Hyoid6. pOH of 0.1M NaOH find pH

pOH = -logOH pOH= -log0.1 = 1pW = pH + pOH pH = 14 – 1 = 13

7. Antithyroid used for gravies disease8. All cause anemia (bleeding) except GERD9. H.pylori associated with peptic ulcer.10. Which is not in duodenal lumen: - adrenal gland 11. DNA sequence is Adenine, Guanine, Cytosine,

Thiamine or except Uracil12. Active form of vit.D is 1,25-dihydroxycholecalciferol13. Iron undergo with defiroxamin – chelation reaction14. Iron cause microcytic anemia15. All are true about iron except- give for 12month16. Which contain epithelial cell all except – bile salts,

sweat, milk, saliva, hydrochloric acid17. OU means – both eye

18. Haploid is one set of chromosome19. P.O.S is point of sale20. Fluticasone which is correct – rinse mouth after use21. Use disposal bags for all except – razor blades22. SNRI is venalfexine23. Canada health cover all except - outpatient

prescription24. Major inhibitory neurotransmitter- GABA\25. Calculate gross margin in %

Gross M= sales – cost of good sales X 100 Sales

26. Calculate how many tablets required for family of 5people having malaria5X6= 30tablets

27. All correct about Leukotrine except 1) product of arachidonic acid not lipo-oxygenase 2) treatment of chronic

asthma 3) acute asthma 4)essential fatty acid (5) granulocyte cells (ans)

28. Restrictive endonuclease cleavage DNA at special site

29. Nystatin mechanism of action cell lysis or leakage of cells

30. Equilibrium between organic (oil) and water Ans partition coefficient

31. Calculate coefficient of variance given standard deviation and mean C.V. = Standard Deviation X 100 Means

32. Calculate ARR (Absolute Risk Reduction)33. Ca++ is absorbed from PTH from distal tubule34. Parental lipid emulsion need phospholipids

35. A person complains from the side effect of drug, patient told the doctor and doctor still give him the medication what pharmacist have to do talk to the doctor

36. Vitamin lack in smoker vitamin C37. Vitamin D3 is hormone

38. LH & FSH are secreted from anterior pituitary gland39. All are action of glutamine acid except

40. Proteins separated by western blotting41. Megaloblastic anaemia is due to deficiency of vit.

B12 and folic acid

42. Meningitis treated by ceftriaxone43. Drugs highly bound albumin44. Which highly bound to opoid (Delta) (enkepilin) 45. Which is responsible for muscle relaxing Ach with Nicotine

46. Indol is found in serotonin47. Paralysis of ciliary muscle is cycloplegia48. Alpha1 cause all except arteriodilation49. Embolism is clotting of blood50. Angina treated by all except diuretic51. CHF include all except 52. Abundant Ion in plasma HCO353. Class I antiarrythmic due Na sensitivity54. TSH from anterior pituitary gland55.