Ivana Pavlinac Dodig, M.D., Ph.D.neuron.mefst.hr/docs/katedre/neuroznanost/Basic... ·...
Transcript of Ivana Pavlinac Dodig, M.D., Ph.D.neuron.mefst.hr/docs/katedre/neuroznanost/Basic... ·...
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Ivana Pavlinac Dodig, M.D., Ph.D.
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1. Brainstem
1. Medulla oblongata
2. Pons
3. Mesencephalon
2. Cranial nerves
3. Cerebellum
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Connecting spinal cord to cerebrum and cerebellum.
Suprasegmental region of CNS.
Medulla oblongata
Pons
Mesencephalon
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Grey matter continuity – from spinal cord via
brainstem tegmentum to diencephalon
White matter continuity – long ascending and
descending fibers
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Physiological roles:
Regulation of breathing
Regulation of cardiovascular system
Regulation of gastro-intestinal system
Regulation of movements
Regulation of body balance
Regulaation of eyes movements
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1. Ventral or basal part (basis) = motor pathways
2. Middle part or tegmentum = sensory pathways, reticular formation, cranial nerve nuclei
3. Dorsal part or tectum – only in midbrain; visual and auditory system
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Long descending motor pathways:
Corticospinal
Corticobulbar
Corticopontine
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Cranial nerves nuclei
Reticular formation
Big extrapyramidal motor nuclei (nucl. ruber and substantia nigra)
Special monoaminergic tegmental nuclei (nucl. raphe, VTA, locus coeruleus)
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Sensory: lemniscus medialis, tractus spinothalamicus and trigeminothalamicus
Extrapyramidal
Non-specific ascendent pathways (serotoninergic, noradrenergic and cholinergic)
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50 nuclei
Paramedial area – raphe + reticul. nuclei
Medial area
Lateral area
Physiological roles:
Modulation of sensory transmission to the cortex
Regulation of motor activity
Autonomic regulation
Sleep and wakefulness cycle
Modulation of emotional behaviour
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Reticular nuclei of the pons – excitation of the antigravity muscles
Medullary reticular nuclei – inhibition of the antigravity muscles
antagonistic action
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Rostral third = open medulla Caudal 2/3 = closed medulla Dorsal surface of tegmentum = bottom of IV.
ventricle Lissauer’s zone = tractus spinalis n. trigemini
Pyramids = corticospinal tract; decussation Olives = inferior olivary nucl. Nucl. gracilis and cuneatus
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Major fiber tracts Internal nuclei
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Tegmentum = extrapyramidal motor and sensory pathways (lemniscus medialis, tractus spinothalamicus*, spinotectalis, spinoreticularis* and spinocerebellaris) and RF
FLM (connecting vestibul. nuclei and lower motor neurons)
* lemniscus spinalis
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Tractus corticospinalis
Tractus tectospinalis
Tractus rubrospinalis
Tractus reticulospinalis lat. and med.
Fasciculus longitudinalis medialis ▪ Descending part (medial vestibulospinal tract)
▪ Ascending part (from medial, lateral, and superior vestibular nuclei to pons and midbrain; information about head position to cranial nerves)
Lemniscus medialis
Tractus spinalis n. trigemini – somatosensory information from the head
(Neuron II)
Tractus spinothalamicus
Tractus spinocerebellaris
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mo
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se
ns
ory
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Reticular formation
Nucl. gracilis and cuneatus
Inferior olivary nuclei (spino-olivary and rubro-olivary fibers; to cerebellum)
Nucl. spinalis n. trigemini (pain and temperature from head)
Cochlear nuclei (n.VIII)
Vestibular nuclei (n.VIII)
Hypoglossal nucl. (n.XII)
Nucl. ambiguus (n.IX & X)
Nucl. tractus solitarii (n.IX & X)
Dorsal motor vagal nucl. (n.X)
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1. Level of pyramidal decussation 2. Level of medial lemniscus decussation
(+accessory cuneate nucl. – external arcuate fibers – cuneocerebellar tract – inferior cerebellar peduncle: unconscious proprioception from upper limbs)
3. Rostral half of medulla – cranial nerve nuclei
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General somatic efferent neurons (GSE)
Special visceral efferent neurons (SVE)
General visceral efferent neurons (GVE)
General visceral afferent neurons (GVA)
Special visceral afferent neurons (SVA)
General sensory afferent neurons (GSA)
Special sensory afferent neurons (SSA)
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GSE – hypoglossal nucl.
SVE – nucl. ambiguus (IX, X)
GVE – parasympathetic (dorsal motor vagal nucl., nucl. salivatorius inferior)
GVA – solitary nucl. (IX, X) – cardiovascular and respiratory reflexes
SVA – gustatory portion of the solitary nucl. (taste)
GSA – spinal nucl. of trigeminal nerve
SSA – vestibular and cochlear nuclei
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GSE
SVE
GVE
GVA & SVA
GSA
SSA
GSE – SVE – GVE – GVA & SVA – GSA – SSA
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Lateral medullary syndrome (Wallenberg’s)
Contralateral body and ipsilateral face loss of pain and temperature (spinothalamic and spinal trigeminal tract), loss of gag reflex, hoarseness, difficulty with speech and swallowing (nucl. ambiguus)
Horner’s syndrome = loss of sympathetic functions
Medial medullary syndrome (Dejerine’s)
Pyramid, medial lemniscus and root fibers of n. XII
Dorsal medullary syndrome
Inf. cerebellar peduncle (ataxia), vestibular nuclei (nystagmus, vomiting, vertigo)
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Basis:
fibers
nuclei
Tegmentum:
fibers
nuclei
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Fasciculi longitudinales
corticospinal
corticobulbar (corticonuclear) interneurons of RF
corticopontine
Transverse pontine fibers (pontocerebellar)
Nuclei pontis (deep)
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Fibers:
fasciculus longitudinalis medialis
lemniscus medialis
spinothalamic and trigeminothalamic pathways
lemniscus lateralis (auditory pathway)
extrapyramidal pathways
tractus rubrospinalis
tractus tectospinalis
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Nuclei pontis:
RF (including raphe nuclei),
auditory relay structures: corpus trapeziodeum, superior olivary nucleus (from cochlear nuclei)
nucleus locus coerulei,
cranial nerves nuclei (V, VI, VII, superior and lateral vestibular nuclei)
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The locked-in syndrome
large infarct of the basilar pons – corticobulbar and corticospinal tracts
communication by blinking and moving eyes
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Tectum (corpora quadrigemina) Tegmentum Basis (crus cerebri)
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Colliculi inferiores (auditory relay component; fibers of lemniscus lateralis from cochlear, sup.olivary nucl., and trapeziod body; to CGM – brachium of the inf. colliculus)
Colliculi superiores (inputs from retina; projects to cervical spinal cord via tectospinal tract)
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PAG (enkephalin-modulation of pain; regulation of autonomic, affective
and emotional functions)
Cranial nerves nuclei (III,IV+MLF)
L&M lemniscus, spinothalamic, trigeminothalamic pathways
RF (including raphe – somatomotor, autonomic and visceral regulation)
Decussation of the superior cerebellar peduncle
Substantia nigra
Nucleus ruber (rostral half, motor functions)
VTA – dopaminergic mezocortical system
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Posterior commissure (pretectal area – coodination of eyes’ movements)
Thalamic structures (pulvinar, medial and lateral geniculate nuclei)
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Pretectal area (pupillary light reflex)
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Sensory:
I.
II.
VIII.
Motor:
IV.
VI.
XI.
XII
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Genereal somatic efferents (GSE):
CN III, IV, VI, XII
skeletal muscles derived from somites Special visceral efferents (SVE):
CN V, VII, IX, X, XI
skeletal muscles derived from branchial arches General visceral efferents (GVE = autonomic):
CN III, VII, IX, X
smooth muscles and glands 38
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Capsula interna Brainstem
Cranial nerves’ nuclei
Neuron I
(upper
motoneuron) Neuron II
(lower
motoneuron)
Precentral gyrus (area 4*) Tractus
corticobulbaris
n. III, IV, V, VI, VII, IX, X, XI, XII
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General somatic afferents (GSA)
CN V, VII, IX, X
sensations of pain, temp, touch, pressure
Special sensory afferents (SSA)
CN II, VIII
From highly specialized somatic receptors
Special visceral afferents (SVA)
CN I (olfaction), CN VII, IX, X (taste) – chemoreceptors
General visceral afferents (GVA)
CN IX and X (visceral pain, baroreception, general unpleasent feelings)
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41 GSE SVE GVE
SSA GSA SVA+GVA
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SVA (receptors are chemoreceptors)
Enters the brain through the cribriform plate and supplies the olfactory bulb
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SSA
Conveys visual signals to the CNS
Enters the brain at the level of the preoptic
region of the diencephalon
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GSE – extraocular eye muscles
GVE – parasympathetic inervation of the pupillary and ciliary muscles
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Motor nucleus:
situated in the mesencephalon (level of the superior colliculus) – fossa interpeduncularis – the orbit
Superior, medial, and inferior rectus musles, inferior oblique and levator palpebrae superior muscle
Bilateral corticobulbar inervation
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Westphal – Edinger nucleus
Most of the fibers: ciliary ganglion (m. constrictor pupillae*)
Some fibers pass through ciliary ganglion and synapse in episcleral ganglion – ciliary muscle (accomodation)
* M. dilatator pupillae – sympathetic fibers from superior cervical gangl.
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GSE M. obliquus superior – moves eye downward
while in medial position
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SVE (muscles of mastication; upper motoneuron = bilateral inputs from the
cortex; lower motoneuron lesions – difficulties in chewing and biting responses)
GSA (somatosensory inputs from the anterior 2/3 of the head)
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GSA from the anterior 2/3 of the head Three principal divisions:
Ophtalmic
Maxillary
Mandibular
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Ganglion semilunare
Gasseri
Trigeminal nerve
Tractus spinalis n.V.
Neuron I Neuron II
VPM of the thalamus
Neuron III
Internal capsule Postcentral gyrus
(area 3,1,2)
Skin receptors
Ventral trigeminothal.tract
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Ganglion semilunare
Gasseri
Main sensory nucl. Of n.V. (pons)
Neuron I Neuron II
VPM of the thalamus
Neuron III
Internal capsule Postcentral
gyrus (area 3,1,2)
Skin receptors
Ventral trigeminothal.
tract
Dorsal trigeminothal.
tract
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Muscle spindles in masticatory muscles and temporomandibular joint – via mandibular branch
Neuron I = mesencephlic nuceus
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Trigeminal neuralgia (tic douloureux) Often localized to a portion of one side of the
face (associated with a specific branch) Unknown etiology (irritation of the trigeminal
nerve by inflammation, tumor, or vascular lesion)
Therapy? Surgery?
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GSE M. rectus lateralis – moves eye laterally Clinical disorder: medial strabismus
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Motor components:
SVE (muscles derived from the second branchial arch)
GVE (parasympathetic: salivation, lacrimation, nasal cavity mucosal secretion)
Sensory components:
GSA (somesthetic impulses from the back of the ear and external auditroy meatus)
SVA (taste)
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SVE
Muscles of facial expression, auricular, posterior belly of digastric , styloyoid, platysma and stapedius muscle
GVE - parasympathetic inervation
from the superior salivatory nucl. to the submandibular (submandibular and sublingual glands) and pterygopalatine ganlion (lacrimal, nasal and palatine glands)
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SVA – taste from the anterior 2/3 of the tongue – geniculate ganglion – solitary nucl. – thalamic VPM nucl.
GSA – back of the ear and external auditory meatus – geniculate ganglion – spinal tract of the trigeminal nucl.
Pain and temp, pressure, tactile stimuli
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Upper part of the face = bilateral inervation Lower part of the face = contralateral inervation
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SSA Auditory and vestibular signals for the CNS
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Motor components:
SVE (muscles derived from the branchial arches)
GVE (salivation)
Sensory components:
GSA (somesthetic impulses from the back of the ear)
GVA (changes of the blood pressure)
SVA (taste and blood oxygen level)
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SVE – from the nucl. ambiguus
M. stylopharyngeus – speech and swallowing
GVE – from the inferior salivatory nucl. to the otic ganglion
Parasympathetic inervation of the parotid gland - salivaton
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GVA – baroreceptors in carotid sinus – inferior (petrosal) ganglion – solitary nucl.
Carotid sinus baroreflex
GSA – tympanic membrane and skin of the external ear, posterior third of the tongue, eustachian tube, tonsil and upper part of the pharynx – superior ganglion – spinal trigeminal nucl.
Pain and temp, pressure, tactile stimuli
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SVA
Respiratory functions: chemoreceptors (PaO2, PaCO2, pH of the blood) in the carotid body – inferior ganglion – solitary nucleus, RF
▪ Carotid body chemoreflex
Taste functions: taste buds in posterior third of the tongue – inferior ganglion – solitary nucl. – VPM thalamic nucl.
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Motor components:
SVE (muscles derived from the branchial arches)
GVE (body viscera)
Sensory components:
GSA (somesthetic impulses from the back of the ear)
GVA (changes of the blood pressure)
SVA (taste and blood oxygen level)
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SVE – from the nucl. ambiguus
Muscles of the pharynx and larynx – role in speech
GVE – from the dorsal motor nucl.
Parasympathetic inervation of the body viscera to left colic flexure
Bronchoconstriction, speeding up of peristalsis, cardiac cycle slowing, increases in bronchi, stomach, pancreas and intestines’ secretion
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GVA – body viscera and aortic arch – inferior (nodose) ganglion – solitary nucl.
Unconscious (baroreceptors in aortic arch, part of baroreceptor reflex) and conscious (thirst, hunger) sensory inputs from the viscera
GSA – back of the ear and external auditory canal – superior (jugular) ganglion – spinal trigeminal nucl.
Pain and temp, pressure, tactile stimuli
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SVA
Respiratory functions: chemoreceptors (PaO2, PaCO2, pH of the blood) in the aortic body – inferior ganglion – reticular formation
Taste functions: taste buds in epiglottis and posterior pharynx wall – inferior ganglion – solitary nucl. – VPM thalamic nucl.
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SVE / GSE Ventral horn cells of first 5-
6 cervical segments M. trapezius and
sternocleidomastoideus Contralateral turning and
lifting of the head Supranuclear paralysis =
contralateral
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GSE
Control of the shape and position of the tongue
Extrinsic (styloglossus, hyoglossus, genioglossus) and intrinsic muscles of the tongue
Damage –protruded tongue deviates to the side of the lesion
Contralateral inervation! 70
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Nerve Nucleus Ganglion Brainstem location
N. oculomotorius Westphal-Edingerova Ciliary Mesencephalon
N. facialis Nucl. salivatorius sup. Submandibulary Pterygopalatine
Pons
N. glossopharyngeus Nucl. salivatorius inf. Oticum M. oblongata
N. vagus Nucl. dorsalis n. vagi At visceral organs M. oblongata
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Integration of information from spinocerebellar pathways, vestibular nuclei and cortex (via pons and cerebellar peduncles)
Cortex, white matter, deep nuclei Two hemispheres + vermis Main neurotransmitter: GABA
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Attached to the brainstem by:
Inferior cerebellar peduncle – fibers from spinal cord and lower brainstem regions
Middle cerebellar peduncle – cortex – pons – cortex cerebelli
Superior cerebellar peduncle – to nucl. ruber and VLN of thalamus
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aff
ere
nt
eff
ere
nt
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Folia; no gyri and sulci
3 layers of the cells:
Purkinje cells layer Molecular layer Granule cell layer
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Nucleus fastigii (=nucl.medialis) – to RF and vestibular neurons Nucleus globosus Nucleus emboliformis Nucleus dentatus (=nucl.lateralis) – to VLN of thalamus
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= nucl.interpositus – to nucl. ruber
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Anatomical name Filogenetic name Functional name
Lobus anterior Paleocerebellum Spinocerebellum
Lobus posterior Neocerebellum Pontocerebellum /
Cerebrocerebellum
Lobus flocculonodularis Archicerebellum vestibulocerebellum
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Loss of balance Tremors Lack of coordination of muscles Reduced muscle tone
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