ISSN 0036-8075

6 October 1978Volume 202, No. 4363

LETTERS First-Hand Observers?: J. Davis; R. J. Pike; Marine Environments:Recovery After Oil Spills: J. H. Vandermeulen et al.; AnimalRights: An Old Question: R. W. Oppenheim .

EDITORIAL Archiving Remotely Sensed Data: C. L. Hamlin and W. H. Goodenough

ARTICLES Antibody Diversity: J. G. Seidman et al.

Aspects of Hypothalamic Regulation of the Pituitary Gland: A. V. Schally.

NEWS AND COMMENT

RESEARCH NEWS

There's Trouble in the Air over Transborder Data Flow.

SO2 Emissions Proposals Pose Growth Issue . . . . . . . . . . . . . . . . . . . .

"Radwastes": Leading Policy Role Recommended for Science Adviser .

New Laetrile Study Leaves Cancer Institute in the Pits..............

Briefing: OTA Opens the Fall Season with List of Priorities; Recycling,Reuse, Repairs; New Group Designed to Draw Scientists to AnimalCause.

Chemical Carcinogens: How Dangerous Are Low Doses? .. .. . . . . . . .. . .

29

30

32

33

34

37

AAAS NEWS OOS to Address Research Problems in Science and Technology for PhysicallyHandicapped Individuals: M. R. Redden; Interciencia Marks SecondAnniversary, Sets Symposia; Leo Schubert, 1916-1978; CSFR to Meet;AAAS Committee Seeks Individual Complaints; Fire Damages University of

6

9

11

18

Lisbon; Short Courses for Industrial Scientists and Engineers; ANZAASCongress Set for 1979 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42

BOOK REVIEWS Research in Philosophy and Technology, reviewed by L. Winner; StatisticalMechanics and Statistical Methods in Theory and Application, C. Domb;Nuclear Division in the Fungi, J. H. Burnett; Development, Functionand Evolution of Teeth, P. D. Gingerich; Books Received . . . . . . . . . . . 44

REPORTS Microstructure ofAgglomerated Suspended Sediments in Northern ChesapeakeBay Estuary: C. F. Zabawa . . . . . . . . . . . . . . . . . . . . . . . . . 49

Larval Bivalve Shell Morphometry: A New Paleoclimatic Tool?:R. A. Lutz andD. Jablonski . . . . . . . . . . . . . . . . . . . . . . . . . 51

Genetically Determined Sex-Reversal in 46,XY Humans: J. German et al. . . . . . 53

Manufactured Hexaparental Mice Show That Adults Are Derived from ThreeEmbryonic Cells: C. L. Markert andR. M. Petters . . . . . . . . . . . . . . . 56

Prevention of Death from Metastases by Immune RNA Therapy: B. S. Wang,S. R. Onikul, J. A. Mannick . . . . . . . . . . . . . . . . . . . . . . . . . . . 59

Phenolic Content of Vegetation in Two African Rain Forests: EcologicalImplications: D. McKey et al. . . . . . . . . . . . . . . . . . . . . . . . . . . 61

Giemsa- I 1 Staining ofChromosome 1: A Newly Described Heteromorphism:R. E. Magenis, T. A. Donlon, H. E. Wyandt . . ...... ...... ..... 64

Impulse Blockade in Frog Cardiac Ganglion Does Not Resemble PartialDenervation in Changing Synaptic Organization: S. Roper and C.-P. Ko . . . . 66

Induction of Ovalbumin Synthesis in Immature Chicks by Actinomycin D andThioacetamide: 0. K. Sharma . . . . . . . . . . . . .6.8.. . . . . . . . . . . 68

Vitamin DI-Induced Calcium Binding Protein in Bone Tissue:S. Cihristakos andA. W. Norman ....... . . . .. . . . . . . . . . . . . 70

Technical Comments: Grand Banks and J-Anomaly Ridge: P. D. Rabinowitz,S. C. Cande, D. E. Hayes; F. M. Gradstein, A. C. Grant, L. Jansa . . . . . . . 71

COVER

Handmade mouse. This tricoloredmouse was manufactured by geneticengineering techniques. The hexapa-rental chimeric animal was producedby aggregating three geneticallymarked embryos (white, yellow, andblack) at the eight-cell stage. See page56. [Bill Sacco, Yale University, New

____ ____ ____ ____ ____ ____-__---------_____-_ Haven, Connecticut]

6 October 1978, Volume 202, Number 4363

AMERICAN ASSOCIATION FORTHE ADVANCEMENT OF SCIENCEScience serves its readers as a forum for the presenta- Archi

tion and discussion of important issues related to the ad-vancement of science, including the presentation of mi-nority or conflicting points of view, rather than by pub- Sincelishing only material on which a consensus has beenreached. Accordingly, all articles published in Science- mote seincluding editorials, news and comment, and book re- telligencviews-are signed and reflect the individual views of theauthors and not official points of view adopted by the StudyingAAAS or the institutions with which the authors are af- when thfiliated.grain great int

Editorial Boardalpoi1978: RICHARD E. BALZHISER, JAMES F. CROW, tal polic

HANS LANDSBERG, EDWARD NEY, FRANK W. PUTNAM, ords ofMAXINE SINGER, PAUL E. WAGGONER, F. KARL WIL placeablLENBROCK

1979: E. PETER GEIDUSCHEK, WARD GOODENOUGH, DeserN. BRUCE HANNAY, MARTIN J. KLEIN, FRANKLIN A. numberLONG, NEAL E. MILLER, JEFFREY J. WINE

PubHsher processiWILLIAM D. CAREY ly under

Editor vegetatioPHILIP H. ABELSON sample (

Editorial Staff under thManaging Editor Business Manager continueROBERT V. ORMES HANS NUSSBAUM mote seiAssistant Managing Editor Production EditorJOHN E. RINGLE ELLEN E. MURPHY ManyNews and Comment: BARBARA J. CULLITON, Editor; with un]

WILLIAM J. BROAD (intern), LUTHER J. CARTER, CON- affectedSTANCE HOLDEN, DEBORAH SHAPLEY, R. JEFFREYSMITH, NICHOLAS WADE, JOHN WALSH. Editorial As- significasistant, SCHERRAINE MACKResearch News: ALLEN L. HAMMOND, Editor; RICH- ture. Th

ARD A. KERR, GINA BARI KOLATA, JEAN L. MARX, prolifermTHOMAS H. MAUGH II, WILLIAM D. METZ, ARTHUR L. A senROBINSON. Editorial Assistant, FANNIE GROOMAssociate Editors: ELEANORE BUTZ, MARY DORF- sensed (

MAN, SYLVIA EBERHART. JUDITH GOTTLIEB how or NAssistant Editors: CAITILIN GORDON, RUTH KUL- and imp

STAD, LOIS SCHMITT, DIANE TURKINBook Reviews: KATHERINE LIVINGSTON, Editor; once its

LINDA HEISERMAN, JANET KEGG The pLetters: CHRISTINE KARLIKICopy Editor: ISABELLA BOULDIN dOmain.Production: NANCY HARTNAGEL, JOHN BAKER; YA yet beer

Li SWIGART, ELEANOR WARNER; JEAN ROCKWOOD, of existiLEAH RYAN. SHARON RYANCovers, Reprints, and Permissions: GRAYCE FINGER, importa

Editor; CORRINE HARRIS, MARGARET LLOYD tually reGuide to Scientific Instruments: RICHARD SOMMER will pro'Assistant to the Editors: RICHARD SEMIKLOSEMembership Recruitment: GWENDOLYN HUDDLE nity toMember and Subscription Records: ANN RAGLAND The r

EDITORIAL CORRESPONDENCE: 1515 Massachu- files issetts Ave., NW, Washington, D.C. 20005. Area code202. General Editorial Office, 467-4350; Book Reviews,4674367; Guide to Scientific Instruments, 467-4480; tence isNews and Comment, 4674430; Reprints and Per-missions, 467-4483; Research News, 467-4321; Cable: We htAdvancesci, Washington. For "Instructions for Contrib- even huutors," write the editorial office or see page xi, Science,29 September 1978. comingBUSINESS CORRESPONDENCE: Area Code 202. ful humBusiness Office, 4674411; Circulation, 4674417.

Advertiing Representatives rl evolDirector: EARL J. SCHERAGO straintsProduction Manager: MARGARET STERLING vention.Advertising Sales Manager: RICHARD L. CHARLESMarketing Manager: HERBERT L. BURKLUND War II,

Sales: NEW YORK, N.Y. 10036: Steve Hamburger,_1515 data souBroadway (212-730-1050); SCOTCH PLAINS. N.J. 07076:C. Richard Callis, 12 Unami Lane (201-889-4873); CHI- be takerCAGO, ILL. 60611: Jack Ryan, Room 2107, 919 N. Mich- wiped oigan Ave. (312-DE-74973); BEVERLY HILLS, CALIF.9021 1: Winn Nance, I I I N. La Cienega Blvd. (213-657- -CHRIS2772); DORSET, VT. 05251: Fred W. Dieffenbach, Kent ofAnthrHill Rd. (802-867-5581)ADVERTISING CORRESPONDENCE: Tenth floor,1515 Broadway, New York, N.Y. 10036. Phone: 212-730-1050.

SCIENCE

iving Remotely Sensed DataWorld War II an immense body of data has been obtained by re-ensing techniques. Although intended primarily for military in-:e, these data are an unprecedented resource for systematicallyg how human action is changing the earth's environments in a timeese effects are increasing and are often irreversible. Processes ofterest to social and biological scientists and crucial for environmen-:y cannot be effectively studied without the synoptic, ongoing rec-change these data provide. They are, therefore, a precious and irre-le resource.rts, for example, spread as a result of the complicated interplay of aof processes, including various kinds of human activity. Thesees and the ways in which human activity affects them are imperfect-rstood. Their study requires repeated observations of such things asion, soils, water, and human settlement and other activity for a largeof localities. Monitoring for this purpose is now being implemented.e auspices of the United Nations, but its success will depend on theed accumulation and preservation of the data base derived from re-,nsing.eother modifications of the biosphere are proceeding rapidly also,known long-term consequences. Long stable ecosystems are beingin a variety of ways by progressive deforestation, the paving of

.nt areas of urban watersheds, and the industrialization of agricul-ie problems for which remotely sensed data will be invaluable areating.ious threat to this data source arises from the rate at which remotelydata are themselves accumulating. The question is now arising ofwhether to preserve them. If thoughtfully drawn plans are not madeplemented soon, this data resource may be destroyed needlesslymilitary use has been exhausted.?roblem has two aspects. First, some of the data are in the public.Their preservation for future use requires funding, which has notn provided, and careful plans for archiving. Second, the greater parting remotely sensed data are not in the public domain. The strategicnce of these classified records diminishes with time and will even-ach the vanishing point. When they become declassified, these datavide the bulk of the information on which this unparalleled opportu-study environmental processes rests.record suggests that preservation of detailed strategic intelligencenot often accomplished. Public appeals for their maintenance ared, since they are calls for the retention of something whose exis-not acknowledged.ave arrived at a point, however, where the threats to national andman existence are no longer largely military in nature. They aremore and more from the increasing expenditure of energy for peace-tan purposes. What once were long-term processes subject to natu-utionary constraints are now accelerating rapidly, and natural con-have been, and continue increasingly to be, altered by human inter-The vast body of remotely sensed data accumulated since World

in both the public and classified domains, is the most important newurce we have for monitoring these processes. Deliberate steps mustn to ensure that potential benefits vital to our national interest are notut by shortsighted destruction of this burgeoning record.STOPHER L. HAMLIN AND WARD H. GOODENOUGH, Departmentropology, University ofPennnsylvania Museum, Philadelphia 19104