Is smoking sufficient to explain the large difference in lung cancer incidence between Finland and...
1
138 intermediate junctions, or desmosomes were 6.4, 8.2, and 11.3 months, respectively. Nevertheless, this ultrastructural subclassification is not as effective as that obtained from careful cinical staging. Secretory Component in Pulmonary Adenocarcinoma and Mesothelioma. Kondi-Paphitis, A., Addis, B.J. Depart- ment of Histopathology, Brompton Hospital, London SW3 6HP, U.K. His- topathology 10: 1279-1287, 1986. The distribution of secretory com- ponent was examined by an im- munoperoxidase method in 40 pulmonary adenocarcinomas, ii malignant pleural mesotheliomas and areas of normal lung adjacent to the tumours. Secretory com- ponent was demonstrated in tumour cells in 25 (67%) adenocarcinomas. Its presence correlated with the degree of differentiation but was not related to tumour pattern. In the normal lung secretory component can be demonstrated in bronchial ciliated cells, bronchial gland serous cells, bronchiolar epithelium and hyperplastic alveolar epithelium. Although not usually detec- table in normal mucous cells it was frequently present in mucin-producing tumours. None of the mesotheliomas ex- amined contained secretory component and this may be an additional useful feature in the differential diagnosis between mesothelioma and adenocarcinoma. Concordance of Histological Class- ification of Lung Cancer With Special Reference to Adenocarcinoma of Osaka, Japan, and the North-West Region of England. Hanai, A., Whittaker, J.S., Tateishe, R. et al. Osaka Cancer Registry, Department of Field Research, Centre for Adult Diseases, Osaka, Japan. Int. J. Cancer 39: 6-9, 1987. In routinely collected data adenocarcinoma of the lung appeared to be 3 times more frequent in Osaka, Japan, than in the North-Western (NW) Region of England (Manchester). Before embarking on comparative epidemiologi- cal studies, it was decided to inves- tigate the comparability of histologi- cal diagnosis. Specimens from 60 NW Region lung cancer patients and 52 Osaka patients were exchanged and reviewed. The entire material was then independently assessed by the WHO Col- laborating Centre for Histological Classification of Tumours. The inter- pretation of the WHO Classification (WHO, 1981) by the NW Region and by Osaka was upheld by the WHO Collaborat- ing Centre in 89% and 93% of all cases and in 97% and 100% of adenocarcinoma cases respectively. Agreement between the 2 centres was 88% for the main cell types. Differences in the frequency of adenocarcinoma of lung between the NW Region and Osaka are thus not due to diagnostic artefact and require further exploration. The aetiological implica- tions of the finding that many Chinese and Japanese women with lung adenocar- cinoma do not smoke (77% in Osaka) are discussed. Is Smoking Sufficient to Explain the Large Difference in Lung Cancer In- cidence Between Finland and Norway? Hakulinen, T., Magnus, K., Tenkanen, L. Finnish Cancer Registry, SF-00170 Helsinki, Finland. Scand. J. Soc. Med. 15: 3-10, 1987. In the 1960s, lung cancer among Finnish men was about 3.5 times as com- mon as among Norwegian men. A study by Pedersen et al. in 1962 indicated that the difference in contemporary smoking habits could account for only part of the difference in lung cancer incidence in men between the countries. In that study, smoking habits in Finland and Norway were investigated via interviews of 8700 people from six areas of each country. For the present study the Fin- nish and Norwegian cancer registries have followed lung cancer morbidity in those areas. When the interval between the recording of smoking habits and lung cancer incidence was 15 years, after adjustment for age and smoking habits, the Finnish males had a rela- tive risk between i.I and 1.6 compared with Norwegian men. The results suggest that, given a sufficiently long latency period, almost the entire difference between Finnish and Norwegian men could be attributed to smoking habits. Bronchial Carcinoids and Phaeochro- mocytomas. A Comparative Study With Special Emphasis on S-100 Protein, Serotonin and Neuron-Specific Enolase (NSE) Immunoreactivity. E1 Salhy, M., Lundqvist, M., Wilander, E. Endocrine Laboratory, Department of Pathology, University Hospital, S-751 85 Uppsala, Sweden. Acta Pathol. Microbiol. Immunol. Scand. Sect. A Pathol. 94: 229-235, 1986. A comparative study of bronchial carcinoids (9 cases) and phaeochromo- cytomas (8 cases) was performed. Both types of tumour exhibited neuron- specific enolase (NSE) immunoreactivity and an argyrophil reaction, and dis- played a few scattered argentaffin and serotonin immunoreactive tumour cells. In addition, four of the nine bronchial carcinoids and six of the eight phaeochromocytomas were S-100 protein immunoreactive. The stained cells were located mainly in the periphery of the tumour cell aggregates and possessed long cytoplasmic processes surrounding unreactive tumour cells. The similarity
Transcript of Is smoking sufficient to explain the large difference in lung cancer incidence between Finland and...
138
intermediate junctions, or desmosomes were 6.4, 8.2, and 11.3 months, respectively. Nevertheless, this ultrastructural subclassification is not as effective as that obtained from careful cinical staging.
Secretory Component in Pulmonary Adenocarcinoma and Mesothelioma. Kondi-Paphitis, A., Addis, B.J. Depart- ment of Histopathology, Brompton Hospital, London SW3 6HP, U.K. His- topathology 10: 1279-1287, 1986.
The distribution of secretory com- ponent was examined by an im- munoperoxidase method in 40 pulmonary adenocarcinomas, ii malignant pleural mesotheliomas and areas of normal lung adjacent to the tumours. Secretory com- ponent was demonstrated in tumour cells in 25 (67%) adenocarcinomas. Its presence correlated with the degree of differentiation but was not related to tumour pattern. In the normal lung secretory component can be demonstrated in bronchial ciliated cells, bronchial gland serous cells, bronchiolar epithelium and hyperplastic alveolar epithelium. Although not usually detec- table in normal mucous cells it was frequently present in mucin-producing tumours. None of the mesotheliomas ex- amined contained secretory component and this may be an additional useful feature in the differential diagnosis between mesothelioma and adenocarcinoma.
Concordance of Histological Class- ification of Lung Cancer With Special Reference to Adenocarcinoma of Osaka, Japan, and the North-West Region of England. Hanai, A., Whittaker, J.S., Tateishe, R. et al. Osaka Cancer Registry, Department of Field Research, Centre for Adult Diseases, Osaka, Japan. Int. J. Cancer 39: 6-9, 1987.
In routinely collected data adenocarcinoma of the lung appeared to be 3 times more frequent in Osaka, Japan, than in the North-Western (NW) Region of England (Manchester). Before embarking on comparative epidemiologi- cal studies, it was decided to inves- tigate the comparability of histologi- cal diagnosis. Specimens from 60 NW Region lung cancer patients and 52 Osaka patients were exchanged and reviewed. The entire material was then independently assessed by the WHO Col- laborating Centre for Histological Classification of Tumours. The inter- pretation of the WHO Classification (WHO, 1981) by the NW Region and by Osaka was upheld by the WHO Collaborat- ing Centre in 89% and 93% of all cases and in 97% and 100% of adenocarcinoma cases respectively. Agreement between the 2 centres was 88% for the main cell
types. Differences in the frequency of adenocarcinoma of lung between the NW Region and Osaka are thus not due to diagnostic artefact and require further exploration. The aetiological implica- tions of the finding that many Chinese and Japanese women with lung adenocar- cinoma do not smoke (77% in Osaka) are discussed.
Is Smoking Sufficient to Explain the Large Difference in Lung Cancer In- cidence Between Finland and Norway? Hakulinen, T., Magnus, K., Tenkanen, L. Finnish Cancer Registry, SF-00170 Helsinki, Finland. Scand. J. Soc. Med. 15: 3-10, 1987.
In the 1960s, lung cancer among Finnish men was about 3.5 times as com- mon as among Norwegian men. A study by Pedersen et al. in 1962 indicated that the difference in contemporary smoking habits could account for only part of the difference in lung cancer incidence in men between the countries. In that study, smoking habits in Finland and Norway were investigated via interviews of 8700 people from six areas of each country. For the present study the Fin- nish and Norwegian cancer registries have followed lung cancer morbidity in those areas. When the interval between the recording of smoking habits and lung cancer incidence was 15 years, after adjustment for age and smoking habits, the Finnish males had a rela- tive risk between i.I and 1.6 compared with Norwegian men. The results suggest that, given a sufficiently long latency period, almost the entire difference between Finnish and Norwegian men could be attributed to smoking habits.
Bronchial Carcinoids and Phaeochro- mocytomas. A Comparative Study With Special Emphasis on S-100 Protein, Serotonin and Neuron-Specific Enolase (NSE) Immunoreactivity. E1 Salhy, M., Lundqvist, M., Wilander, E. Endocrine Laboratory, Department of Pathology, University Hospital, S-751 85 Uppsala, Sweden. Acta Pathol. Microbiol. Immunol. Scand. Sect. A Pathol. 94: 229-235, 1986.
A comparative study of bronchial carcinoids (9 cases) and phaeochromo- cytomas (8 cases) was performed. Both types of tumour exhibited neuron- specific enolase (NSE) immunoreactivity and an argyrophil reaction, and dis- played a few scattered argentaffin and serotonin immunoreactive tumour cells. In addition, four of the nine bronchial carcinoids and six of the eight phaeochromocytomas were S-100 protein immunoreactive. The stained cells were located mainly in the periphery of the tumour cell aggregates and possessed long cytoplasmic processes surrounding unreactive tumour cells. The similarity
