INVENTIVE SOLUTIONSFOR OUTSTANDING RESULTSSOFT TISSUE IMPLANTS FOR DERMAL INJECTION

CE Class III Medical Device

RRS® Hyalift® 35 RRS® Hyalift® 75 RRS® Hyalift® 75 Proactive

RRS® HA Injectable RRS® HA Tensor Lift

RRS® HA Skin Relax with BoNtA 568®

RRS® Silisorg RRS® Silisorg HA RRS® Silisorg Tensor

RRS® HA Whitening RRS® HA Strimatrix RRS® HA Cellutrix

XL Hair®

RRS® HA Eyes

RRS® UNIQUE FORMULATIONSTailored to each indication, for face & bodyEasy to use & approved protocolsOne product - One treatmentQuick responseStable & durable results Compatible with other products & methodsCost effective

INNOVATIONRRS® HYDRO-BOOSTERSUSE THE VALUABLE SUBSTANCE UP TO THE LAST DROP

3 mLsyringe

Intensive Rejuvenation

In-Depth Hydrobalance

Inhibits Dermal Atrophy

PRODUCT

RRS® HYALIFT® 35RRS® HYALIFT® 75RRS® HYALIFT® 75 PROACTIVE

RRS® HA INJECTABLERRS® HA SKIN RELAX with BoNtA 568®

RRS® HA TENSOR LIFTRRS® HA WHITENINGRRS® HA EYESRRS® HA STRIMATRIXRRS® HA CELLUTRIX

XL HAIR®

RRS® SILISORGRRS® SILISORG HARRS® SILISORG TENSOR

DERMAL IMPLANT

REPAIRS | REFILLS | STIMULATES

DESCRIPTION

7 mg/mL non cross-linked Hyaluronic Acid15 mg/mL non cross-linked Hyaluronic Acid15 mg/mL non cross-linked Hyaluronic Acid + Aminoacids & Resveratrol

6 mg/mL non cross-linked Hyaluronic Acid + anti photo aging A.S.1 mg/mL non cross-linked Hyaluronic Acid + relaxing A.S.6 mg/mL non cross-linked Hyaluronic Acid + tensing A.S.1 mg/mL non cross-linked Hyaluronic Acid + anti pigment effect A.S.5 mg/mL non cross-linked Hyaluronic Acid + for eyes contouring A.S.2 mg/mL non cross-linked Hyaluronic Acid + stretch marks A.S.0.5 mg/mL non cross-linked Hyaluronic Acid + panniculopathy A.S.

0.001 mg/mL non cross-linked Hyaluronic Acid + alopecia A.S.

200 mg/mL Organic Silicium + antioxidant A.S. (Resveratrol)50 mg/mL Organic Silicium + 2 mg/mL non cross-linked Hyaluronic Acid + antioxidant A.S. (Resveratol)25 mg/mL Organic Silicium + tensing effect A.S.

DERMAL IMPLANT ANCILLARY SOLUTION (A.S.)

HASiOrgORGANIC SILICIUM

HYALURONIC ACID &/or

Dermal implant for photo aging and its consequences

Skin rejuvenation +Hydrobalance +Dermal atrophy +

COMPOSITIONHA, non-cross-linked 7,0 mg/mL (35 mg/5 mL)

Dermal implant for photo agingand its consequences

Skin rejuvenation ++Hydro balance +++Dermal atrophy ++

COMPOSITION HA, non-cross-linked 15,0 mg/mL (75 mg/5 mL)

Dermal implant for photo aging and its consequencesIntercellular matrix revitalization

Skin rejuvenation +++Dermal atrophy +++

COMPOSITION HA, non-cross-linked 15,0 mg/mL (75 mg/5 mL)Amino acids, Polyphenols, Antioxidants

Vials containing 5 mL (0,175 fl.Oz)Box of 2 vials / 6 vials Syringe containing 3 mL (0,1 fl.Oz)Box of 1 / 2 / 4 syringes

Vials containing 5 mL (0,175 fl.Oz)Box of 2 vials / 6 vialsSyringe containing 3 mL (0,1 fl .Oz) Box of 1 / 2 / 4 syringes

Vials containing 5 mL (0,175 fl.Oz)Box of 2 vials / 6 vialsSyringe containing 3 mL (0,1 fl .Oz) Box of 1 / 2 / 4 syringes

08/09

5 mL

3-5 mL

Injections mapping for face & neck, décolletéwith RRS® Hyalift

Learn more on www.rrs-inject.com/medinet

06/07

RR

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YALI

FT®

35R

RS®

HYA

LIFT

® 7

5R

RS®

HYA

LIFT

® 75

PR

OA

CTIV

E

Dermal implant for photo aging and its consequences

Skin rejuvenation +Hydrobalance +Dermal atrophy +

COMPOSITIONHA, non-cross-linked 7,0 mg/mL (35 mg/5 mL)

Type of injection Microdermal: 30G needle, 3 mL (face) / 3-5 mL (décolleté)Deep dermal:25G or 27G cannula - 5 mL (face)

Frequency 1 session per week · 1 protocol = 4 sessions average

Maintenancerepeat protocol 1-3 times a year

Best combinationRRS® Hyalift + RRS® Silisorg & RRS® Silisorg Tensor

RRS® Hyalift 75

RRS® Hyalift 35

Dermal implant for skin photo aging and dermal atrophy

COMPOSITIONHA, non-cross-linked 6,0 mg/mL (30 mg/5 mL)Organic SiliciumFlavonoids (Hesperidin, quercetin)Vitamins (Vit B-C-F, etc)Antioxidants (Phytic, lipoic acid, etc)Aminoacids (Valine, Taurine, etc)Polyphenols (Viniferins, Resveratrol, etc)Trace elements (Cu, Zn, Co, etc)Coenzymes (NAD, NADP)

Dermal implant for dermal laxityDermal tensing effect

COMPOSITIONHA, non-cross-linked 6,0 mg/mL (30 mg/5 mL)Organic SiliciumFlavonoids (Hesperidin, quercetin)DMAE 0,5%Vitamins (Vit B-C-F, etc)Antioxidants (Phytic, lipoic acid, etc)Aminoacids (Valine, Taurine, etc)Polyphenols (Viniferins, Resveratrol, etc)Trace elements (Cu, Zn, Co, etc)Coenzymes (NAD, NADP)

Vials containing 5 mL (0,175 Fl. Oz)Box of 2 vials / 6 vials

Vials containing 5 mL (0,175 Fl. Oz)Box of 2 vials / 6 vials

Dermal implant for skin photo agingAnti pigmentation effect

COMPOSITIONHA, non-cross-linked 1 mg/mL (3 mg/3 mL)Arbutin, Aminoethylphosphinic Acid, Retinyl Palmitate, Morus Alba extract, Licorice extract, Vit C, Glycyrrhiza glabra extract, etc.Vitamins (Vit A-C-E, etc)

Vials containing 3 mL (0,10 Fl. Oz)Box of 2 vials / 6 vials

08/09

RR

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A IN

JECT

AB

LER

RS®

HA

TEN

SOR

LIF

TR

RS®

HA

WH

ITEN

INGType of injection

Microdermal / Deep dermal

Frequency 1 session per week · 1 protocol = 6 sessions averageMaintenance repeat protocol 1-3 times a yearBest combination RRS® HA Skin Relax for upper face RRS® HA Eyes for eye contourRRS® HA Injectable + RRS® Silisorg Tensor for photo aging treatment + dermal densification

Injections mapping for face & neck, décolleté with RRS® HA Injectable, RRS® HA Tensor Lift,RRS® HA Whitening

3 mL

RR

S® HA Tensor Lift

RR

S® HA Whitening

3-5 mL RR

S® HA Injectable

3-5 mL

Learn more on www.rrs-inject.com/medinet

Max distance between injection points: RRS® HA Tensor Lift 2 cmRRS® HA Injectable 1 cm

RRS® HA Whitening 0.5 cm

RRS® HA Tensor Lift: 0.1 ml/ injection point RRS® HA Injectable: 0.1 ml/ injection point

RRS® HA Whitening: 0.05 ml/ injection point

PRIZE

Dermal implant for area around the eyesMicrocirculatory enhancement

COMPOSITIONHA, non-cross-linked 5,0 mg/mL (7,5 mg/1,5 mL)Organic SiliciumAntioxidants (Vit C, Resveratrol, etc)Flavonoids (Troxerutin, Hesperidin, etc)Saponins (Ruscogenin, Escin, etc)Polyphenols (Viniferin, Coumarin, etc)Peptides (Dipeptide VW, Pal-GQPR)

Ampoules containing 1,5 mL (0,05 fl. Oz)Box of 2 ampoules / 12 ampoules

Dermal implant for photo aging associated with excessive skin tensionRelaxing effect

COMPOSITIONHA, non-cross-linked 1,0 mg/mL (3 mg/3 mL)Oligopeptides: Pentapeptide-18, Acetyl Hexapeptide-8, Acetyl octapeptide-3

Facial expresions areasAlternative treatment

Vials containing 3 mL (0,10 fl. Oz)Box of 2 vials / 6 vials

RRS® HA Eyes - Best injectableproduct for eye areaWinner 2014 in category “Aesthetic Dermatology”Polish Society Aesthetic Dermatology

Top product in safety and effectiveness More than 4.500 in Poland have cast their vote to RRS® HA Eyes

2014

10/11

RR

S® H

A E

YES

RR

S® H

A S

KIN

REL

AX

WIT

H B

oNtA

568

®

Injections mapping for face & neck, décolletéwith RRS® HA Eyes, RRS® HA Skin Relax

Type of injection Microdermal / Deep dermal

Frequency 1 session per week · 1 protocol = 4 sessions average

Maintenancerepeat protocol 1-3 times a year

Best combinationRRS® Skin Relax + RRS® Hyalift 35/75 for neck and décolletéRRS® HA Eyes can be combined with botulinic toxin

1,5 mLfor both eyes

RR

S® HA Skin Relax

5 mL

RRS® HA Eyes

Dermal implant for the treatment and filling of depressions caused by linear ruptures of stretch marks

COMPOSITIONHA, non-cross-linked 2 mg/mL (20 mg/10 mL)Organic SiliciumFibroblast Growth Factors (FGF)Aminoacids (Glycine, Isoleucine, Lisine, etc)Flavonoids (Quercetin, Kaempferol)Fatty acids (Linoleic, Oleic Acid)Vitamin CSodium DNA

Dermal implant for the treatment of Edematous Fibrosclerotic PanniculopathyStimulates microcirculation

COMPOSITIONHA, non-cross-linked 0,5 mg/mL (5 mg/10 mL)Antioxidants (Vit C, Triferulic Acid, etc)Flavonoids (Cinaroside, Quercetine, Rutin, etc)Vitamins (Vit A-B-C-E, etc)Saponins (Ruscogenin, etc)Fucoxanthin, Caffeine, L-carnitine, etc

Vials containing 10 mL (0,35 fl. Oz)Box of 2 vials / 6 vials

Vials containing 10 mL (0,35 fl. Oz)Box of 6 vials

I N J E CT I O N T E C H N I Q U E S

PAPULA LINEAR HORIZONTAL LINEAR VERTICAL

12/13

RR

S® H

A S

TRIM

ATR

IXR

RS®

HA

CEL

LUTR

IX

10mL

Type of injection Microdermal / Deep dermal

Frequency 1 session per week · 1 protocol = 6 sessions average

Maintenancerepeat protocol 1-3 times a year

Best combinationRRS® HA Strimatrix or RRS® HA Cellutrix + RRS® Silisorg / RRS® Silisorg Tensor

2/3 cm

2/3 cm

Injections mapping for body with RRS® HA Strimatrix & RRS® HA Cellutrix

Dermal implant for the treatment of skin laxity

COMPOSITIONOrganic Silicium 200 mg/mL (1000 mg/5 mL)Resveratrol

Dermal implant for the treatment of UV induced skin photo aging

COMPOSITIONOrganic Silicium 50 mg/mL (250 mg/5 mL)HA, non-cross-linked 2 mg/mL (10 mg/5 mL)Resveratrol

For delicate areas

Dermal implant for the treatment of UV induced skin photo aging and laxity

COMPOSITIONOrganic Silicium 25 mg/mL (125 mg/5 mL)DMAE 0,1%

Ampoules containing 5 mL (0,175 fl. Oz)Box of 12 ampoules

Ampoules containing 5 mL (0,175 fl. Oz)Box of 12 ampoules

Ampoules containing 5 mL (0,175 fl. Oz)Box of 2 ampoules / 12 ampoules

Neck: 5mlArea

Back: 5mlArea

Elbow: 2.5mlArea

Arm: 2.5mlArea

Dermal implant for the treatment of UV induced skin photo aging

COMPOSITIONOrganic Silicium 50 mg/mL (250 mg/5 mL)HA, non-cross-linked 2 mg/mL (10 mg/5 mL)Resveratrol

For delicate areas

14/15

RR

S® S

ILIS

OR

GR

RS®

SILI

SOR

G H

AR

RS®

SILI

SOR

G T

ENSO

R

Type of injection Microdermal / Deep dermal

Frequency 1 session per week · 1 protocol = 6 sessions average

Maintenance repeat protocol 1-3 times a year

Best combinationAny RRS® HA product for microdermal densificationRRS® Silisorg + RRS® Hyalift 35 / RRS® Hyalift 75

Injections mapping for neck, back, elbow and arm with RRS® Silisorg / RRS® Silisorg HA / RRS® Silisorg Tensor

2,5mL

5 mL

5 mL

0.1/0.2 mL / Injection point cm

RR

S® Silisorg Tensor

RRS® Silisorg

RRS® Silisorg HA

Dermal implant for alopecia and activation of hair restoration

COMPOSITIONHA, non-cross-linked 0,001 mg/mL (0,003 mg/ 3 mL) / (0,005 mg/ 5 mL)Organic SiliciumFibroblast Growth Factors (FGF)Copper peptide, deoxyribonucleic acidVitamins (B, H, etc)Flavonoids (Quercetin, etc)TerpenesAminoacids, Antioxidants

Vials containing 3/5 mL (0,10/0,75 fl. Oz)Box of 6 vials

Cells Human Hair dermal papilla cells

Culture plate 24 wells plate

(cellular) 15000 c/well

Culture Medium Mesenchymal stem cell medium +2,5% FBS

Cell synchronization 6 hours starvation

Cell activation Serum free medium +/- product dilution

Proliferation assay MTT assay

Result expression % cell viability = [OD (500mm - 690mm) test product/OD (500mm - 690mm) negative control] x 100

Replicates 3

In vitro study XL HAIR® Increases proliferation of human papilla cells IntroductionIn vitro test has been performed for efficacy assessment of the test product XL HAIR®, using Human Hair dermal papilla cells. The study was performed in Abich laboratory, located in Via 42 Martiri, 213/B - 28924 - Verbania - Italy.The experimentation was done in June 2014.

SummaryAn in vitro test has been performed on XL HAIR® for efficacy assessment on Human Hair dermal papilla cells. Cell proliferation following the exposure to the actives in particular conditions has been evaluated.Cell proliferation after starving at different end times through the MTT assay: cell viability assay using cultured dermal papilla cells from human hair follicles to assess the cell proliferation following exposure to the test sample.

On the basis of the tests carried out, under the adopted experimental conditions, the sample of the test substance,XL HAIR® is able to increase cells proliferationwith respect to untreated control cell cultures. The highest effect (+23.3%) is pointed out at 1mg/mL of active substance after an exposure period of 48 hours.

0.2 mg/ml 1 mg/ml

XL HAIR®

120

140

160

100

% c

ell v

iabi

lity

23% increase

XL HAIR® in vitro study XL HAIR® in vitro study

16/17

XL H

AIR

®

Before/After Before/After

XL HAIR® RESULTS

Clinical results by expert doctors. Skin Tech Pharma Group (Gabriel Siquier, Evgeniya Ranneva, Barbara Kubicka, Aleksandra Djordjevic, etc)

RRS® RESULTSBefore/After

Clinical results by expert doctors. Skin Tech Pharma Group (Diana Yudina, Evgeniya Ranneva, Nenad Stankovic, etc)´

RRS® HA Whitening

RRS® HA Tensor Lift, RRS® HA Eyes

RRS® HA InjectableRRS® Hyalift 35, RRS® Silisorg Tensor

RRS® Hyalift 75

RRS® Hyalift 75 Proactive, RRS® HA Eyes

Before/After

REP

AIR

& B

ALA

NC

Efo

r fa

ceBEST CHOICE in combination with RRS®

SPEC

IAL

CAR

EB

OD

Y &

HA

IR

Day Intensive RepairREJUVENATING COMPLEX

WITH HYALURONIC ACID + PEPTIDES

EyesBEAUTIFIES THE APPEARANCE

OF EYE CONTOUR

Night Intensive Repair RWITH RESVERATROL

Night Intensive Repair MWITH MELATONIN

Night Intensive Repair HWITH HYALURONIC ACID

Relax SkinREJUVENATION

POLY-OLIGOPEPTIDES + MOISTURIZING

Strimatix®

REDUCES THE APPEARANCEOF STRIAE DISTENSAE

Cellutrix®

REDUCES THE APPEARANCEOF ORANGE SKIN

ScalpFitPRE-TREATMENT

SCALP AND HAIR DEEP CLEANSING

RevitalixPOST-TREATMENT

SCALP & HAIR HYDRATION

HairHAIR GROWTH

SPRAY

Aclaranse®

REDUCES THE APPEARANCEOF PIGMENT IRREGULARITIES

Skin RetrievalPOST TREATMENT

SKIN RECOVERY

SKIN TECH PHARMA GROUP SLC/ Pla de l’Estany, 29 · 17486 Castelló d’Empúries · Girona (Spain)

info@skintechpharmagroup.com · www.skintechpharmagroup.comDISTRIBUTOR’S INFORMATION

To learn more about RRS®

protocols & techniques visit MEDINET

www.rrs-inject.com AD_C

ARRS

04www.rrs-inject.com