Introduction workshop "Network analysis for systems nutrition research”
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Introduction on the workshop "Network analysis for systems nutrition research” (4-5 September 2014, Rovereto, Italy) by Marijana Radonjic. For more details see: http://www.edgeleap.com/news/workshop-on-network-analysis-for-systems-nutrition-research-co-organized-by-edgeleap/
Transcript of Introduction workshop "Network analysis for systems nutrition research”
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NETWORK ANALYSIS FOR SYSTEMS
NUTRITION RESEARCH
Marijana Radonjic, PhD
EdgeLeap, The Netherlands
September 4-5, 2014
Piazza Manifattura 1, 38068 Rovereto - Italy
This presentation remains property of EdgeLeap B.V. and is licensed for reuse under a Creative Commons Attribution 4.0 International License (see http://creativecommons.org/licenses/by/4.0/).
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WORKSHOP BACKGROUND
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4th workshop on the theme “Can systems biology add to the Millennium Development goals of optimal
nutrition?”
Focus: computational biology
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COMPLEXITY IN NUTRITION AND
HEALTH RESEARCH
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EMERGING CONCEPTS IN SYSTEMS
NUTRITION
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Reductionism
Homeostasis
Population
Systems approach
Adaptation
Personalized
Network biology: a powerful approach to address these needs
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NETWORK BIOLOGY:
FROM DATA TO KNOWLEDGE
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Discovers relations and systems organization
Particularly suitable for systems nutrition, accounting for multitude of subtle effects
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NETWORK-BASED DATA INTEGRATION,
MINING AND VISUALIZATION
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Output:
• Mechanisms and key features
• Paths perturbed by interventions
• Learn how to steer the system
Input:
• Different assays / data types
• At different complexity levels (molecular, physiological, social, etc.)
• Experimental data, prior knowledge,
• Across disciplines, analytical methods, platforms
• (Homeo)static & dynamic
Micronutrient
Stunting Cognition Immune
status
Protein
SNP
Genotype
DietInflammatory
status
Sanitation
Socio-economic
status
Gut function
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THE WORKSHOP
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Brings together experts from different disciplines to discuss their view on emerging field of network-based systems nutrition
Informal setting: Get engaged!
First day: introduction, get togetherSession topics:1. Set the stage, define the problem2. Network experts3. Statistics experts
Second day: work in groups1 case study (Delta study by Morine, Kaput et al., http://www.ncbi.nlm.nih.gov/pubmed/24879315)
4 working groupsOutcome: data analysis plan/group, followed by 10min presentations
Concluding roundtable discussion: towards a consensus on applicability of network biology to problems in nutritional health
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ENJOY!
