Introduction to MRI Acquisition - fsl.fmrib.ox.ac.ukapps/fsl_MR_physics...Introduction to MRI...
Transcript of Introduction to MRI Acquisition - fsl.fmrib.ox.ac.ukapps/fsl_MR_physics...Introduction to MRI...
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Introduction to MRI Acquisition
James MeakinFMRIB Physics Group
FSL Course, Bristol, September 2012
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What are we trying to achieve?
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What are we trying to achieve?
• Informed decision making:
• Protocols need to be tailored to the problem (Motion? Effect size? Area of activation?)
• Learning some physics will make this less daunting
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What are we trying to achieve?
• Informed decision making:
• Protocols need to be tailored to the problem (Motion? Effect size? Area of activation?)
• Learning some physics will make this less daunting
• A common language:
• Explain your needs to physicists/radiographers
• Understand their response
• There is a LOT of jargon, but you can master it!
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MRI Physics
• Today:
• Basics of (nuclear) Magnetic Resonance
• Image Formation
• Functional MRI
• The BOLD effect
• Acquisition and artefacts
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Nuclear Spin
• Some elementary particles (eg Hydrogen) exhibit “spin”
• Appear to rotate about an axis
• Charge + spin = magnetic moment
spin
H1
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Nuclear Spin
• Some elementary particles (eg Hydrogen) exhibit “spin”
• Appear to rotate about an axis
• Charge + spin = magnetic moment
spinN
S
H1
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Nuclear Spin
• Some elementary particles (eg Hydrogen) exhibit “spin”
• Appear to rotate about an axis
• Charge + spin = magnetic moment
spinN
S
H1
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Magnetic Fields (B)
No Field
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Magnetic Fields (B)
• What happens when you place a bunch of nuclei with spin into a magnetic field?
No Field
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Magnetic Fields (B)
• What happens when you place a bunch of nuclei with spin into a magnetic field?
Main B Field
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Magnetic Fields (B)
• What happens when you place a bunch of nuclei with spin into a magnetic field?
• On average, they’ll tend to align with the field (a net magnetic moment)
Main B Field
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Precession
• A force (Gravity or B Field) tries to tilt the spinning object
• But because of spin, the axis precesses instead of tilting
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• Energy pulse tips magnetisation away from B0
• ...if energy rotates at resonant frequency: RF pulse!
B0
ω0 = γB0
Excitation
courtesy of William Overall
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• Energy pulse tips magnetisation away from B0
• ...if energy rotates at resonant frequency: RF pulse!
B0
ω0 = γB0
Excitation
courtesy of William Overall
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• Once excited, magnetisation precesses at resonance frequency
B0
Precession
courtesy of William Overall
ω0 = γB0
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• Once excited, magnetisation precesses at resonance frequency
B0
Precession
courtesy of William Overall
ω0 = γB0
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• Changing magnetic field induces current in wire
• Precessing magnetisation detected with coil
• Can only detect component in transverse (xy) plane
B0
Signal detection
courtesy of William Overall
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• Changing magnetic field induces current in wire
• Precessing magnetisation detected with coil
• Can only detect component in transverse (xy) plane
B0
Signal detection
courtesy of William Overall
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Magnetic Resonance
• Magnetic: external field (B0) magnetises sample
• Usually detect hydrogen protons in water
• Potentially any element with spin (1H, 19F, 31P...)
• Resonance: magnetization has characteristic frequency
• Also called the “Larmour” frequency
• Proportional to the strength of the magnetic field the spin is in
• For protons, resonance frequency is in RF range
ω0 = γB0
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• Magnetization “relaxes” back into alignment with B0
• Speed of relaxation has time constants: T1 and T2
B0
Relaxation
courtesy of William Overall
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• Magnetization “relaxes” back into alignment with B0
• Speed of relaxation has time constants: T1 and T2
B0
Relaxation
courtesy of William Overall
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Mxy
Signal decaysaccording to T2
in transverse plane
Relaxation: T1 and T2
RF pulse
Time
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Echo time (TE) & T2 contrast
Echo time (TE)
Sig
nal
White matter
Gray matter
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MRI Physics
• Today:
• Basics of (nuclear) Magnetic Resonance
• Image Formation
• Functional MRI
• The BOLD effect
• Acquisition and artefacts
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Making an image
B0
Differentiate between signal from different locations
magnet
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• Add a spatially varying magnetic field gradient (G)
• Field varies linearly along one direction
• Gradient field adds to or subtracts from B0
Making an image
B0G
Differentiate between signal from different locations
magnet
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• Resonance frequency is proportional to total field
B0
Precession
courtesy of William Overall
ω0 = γ(B0+ΔB)
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Magnetic gradients
Higherfrequency
Lowerfrequency
Higher field
Lower field
B0
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• Protons at each position precess at different frequencies
• RF coil hears all of the protons at once
• Distinguish material at a given position by selectively listening to that frequency
Magnetic gradients
Higherfrequency
Lowerfrequency
Higher field
Lower field
B0
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Decoding Frequency: The Fourier Transform
• Expresses a function of time as a function of frequency
• Imagine an orchestra: you differentiate between different instruments based on their frequency
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The Fourier TransformA
mpl
itude
Fouriertransform
Time / s
Fouriertransform A
mpl
itude
Frequency / Hz
Bass
Cellos (loudest)
Violins
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Spatial frequencies
ImageSpace
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Spatial frequencies
ImageSpace
FourierTransform
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Spatial frequencies
Brightness = How much of thisspatial frequency is in your image
ImageSpace K-Space
FourierTransform
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Spatial frequencies
Brightness = How much of thisspatial frequency is in your image
ImageSpace K-Space
FourierTransform
Low Spatial Frequencies
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Spatial frequencies
Brightness = How much of thisspatial frequency is in your image
ImageSpace K-Space
FourierTransform
Low Spatial Frequencies
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Spatial frequencies
Brightness = How much of thisspatial frequency is in your image
ImageSpace K-Space
FourierTransform
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Spatial frequencies
Brightness = How much of thisspatial frequency is in your image
ImageSpace K-Space
FourierTransform
High Spatial Frequencies
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Spatial frequencies
Brightness = How much of thisspatial frequency is in your image
ImageSpace K-Space
FourierTransform
High Spatial Frequencies
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Spatial frequencies
Brightness = How much of thisspatial frequency is in your image
ImageSpace K-Space
FourierTransform
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Spatial frequencies
Brightness = How much of thisspatial frequency is in your image
ImageSpace K-Space
FourierTransform
Delete some spatial frequencies in the
LR direction
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Spatial frequencies
Brightness = How much of thisspatial frequency is in your image
ImageSpace K-Space
FourierTransform
Delete some spatial frequencies in the
LR direction
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Spatial frequencies
Brightness = How much of thisspatial frequency is in your image
ImageSpace K-Space
FourierTransform
Delete some spatial frequencies in the
LR direction
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ky=0
kx=0
2D “k-space” describes contribution of each spatial frequency
xx
x
(2,1)
(0,4)
(8,1)
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What does this have to do with MRI?
• Remember, we detect all excited protons in the object at the same time
• They’re resonating at different frequencies due to the gradients
• We acquire the data in k-space!
• We then fill k-space & Fourier transform it to get the image
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• ➀ Excite magnetization (transmit RF pulse)
• ➁ Wait for time TE (“echo time”)
• ➂ Acquire signal from transverse magnetization (Mxy)
• ➃ Wait until time TR (“repetition time”)
• ➄ Repeat from ➀
RF
Acq
➀ ➁ ➂ ➃ ➄
TE
TR
Simple MRI “pulse sequence”
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Linescan (2DFT) Acquisition
Acquire one line after each excitationUseful for structural images (minimal artefacts)
kx
ky
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Linescan (2DFT) Acquisition
Acquire one line after each excitationUseful for structural images (minimal artefacts)
kx
ky
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Echo-planar Imaging (EPI) Acquisition
Acquire all of k-space in a “single shot”Used for FMRI, diffusion imaging
kx
ky
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Echo-planar Imaging (EPI) Acquisition
Acquire all of k-space in a “single shot”Used for FMRI, diffusion imaging
kx
ky
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SNR =
Signal
!noise
Signal-to-noise ratio (SNR)Signal-to-noise ratio: describes signal “robustness”All else being equal, we want to maximise SNR!!
low SNRhigh SNR
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Signal-to-noise ratio (SNR)
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Protocol choices affecting SNR...
• RF receive coil & field strength
• Timing: TE & TR
• Voxel volume
• Scan duration
• Anything affecting signal!!!
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Protocol choices affecting SNR...
• RF receive coil & field strength
• Timing: TE & TR
• Voxel volume
• Scan duration
• Anything affecting signal!!!
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What affects noise? Acquisition time
scan time
σnoise
Longer acquisition ⇒ less noise ⇒ higher SNR
SNR improves with the square root of scan time
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What affects noise? Acquisition time
scan time
σnoise
Longer acquisition ⇒ less noise ⇒ higher SNR
SNR improves with the square root of scan time
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Larger voxels have signal from more tissue!
• Signal proportional to voxel volume
? 8xSNR
–2x2x2mm has 8x higher SNR than 1x1x1mm!
What affects signal? Voxel volume
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? 8xSNR
Averaging to achieve high resolution
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? 8xSNR
Can we recover lost SNR by averaging?Yes! But it requires a 64-fold increase in scan
time!
Averaging to achieve high resolution
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Contrast-to-noise ratio (CNR)
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MRI Physics
• Today:
• Basics of (nuclear) Magnetic Resonance
• Image Formation
• Functional MRI
• The BOLD effect
• Acquisition and artefacts
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Deoxyhemoglobin is the source of FMRI signal
Oxyhemoglobin: diamagnetic (same as tissue)Deoxyhemoglobin: paramagnetic (magnetic)
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The BOLD Effect [ Ogawa et al, 1990 ]
Blood Oxygenation Level Dependent (BOLD) effect
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The BOLD Effect [ Ogawa et al, 1990 ]
Blood Oxygenation Level Dependent (BOLD) effect
imaging voxel
Creates a range of frequencies in imaging voxel
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HbO2
HbO2
HbO2
HbO2 dHb
dHb
HbO2
HbO2
dHbHbO2
HbO2
dHbdHb
HbO2
dHb = deoxyhemoglobinHbO2 = oxyhemoglobin
capillary
neuron
Vascular Response to Activation
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HbO2
HbO2
HbO2
HbO2 dHb
dHb
HbO2
HbO2
dHbHbO2
HbO2
dHbdHb
HbO2
dHb = deoxyhemoglobinHbO2 = oxyhemoglobin
capillary
neuron
Vascular Response to Activation
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HbO2
HbO2
HbO2
HbO2
O2 metabolism
dHb
dHb
HbO2
HbO2
dHbHbO2
HbO2
dHbdHb
HbO2
dHb = deoxyhemoglobinHbO2 = oxyhemoglobin
capillary
neuron
dHb
Vascular Response to Activation
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O2 metabolism
dHb
dHb
HbO2
HbO2
dHbHbO2
HbO2
dHbdHb
HbO2
dHb = deoxyhemoglobinHbO2 = oxyhemoglobin
capillary
neuron
dHb
dHb
dHb
dHb
dHb
Vascular Response to Activation
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O2 metabolism
dHb
dHb
HbO2
HbO2
dHbHbO2
HbO2
dHbdHb
HbO2
blood flow
HbO2
HbO2
HbO2
HbO2
HbO2HbO2
HbO2 HbO2
HbO2
HbO2HbO2
HbO2
HbO2
HbO2
dHb = deoxyhemoglobinHbO2 = oxyhemoglobin
capillary
neuron
dHb
HbO2
dHb
dHb
dHb
dHb
Vascular Response to Activation
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O2 metabolism
dHb
dHb
HbO2
HbO2
dHbHbO2
HbO2
dHbdHb
HbO2
blood flow
HbO2
HbO2
HbO2
HbO2
HbO2HbO2
HbO2 HbO2
HbO2
HbO2HbO2
HbO2
HbO2
HbO2
dHb = deoxyhemoglobinHbO2 = oxyhemoglobin
capillary
blood volume
HbO2
HbO2HbO2
neuron
dHb
HbO2
HbO2
dHb
dHb
dHb
dHb
Vascular Response to Activation
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O2 metabolism
dHb
dHb
HbO2
HbO2
dHbHbO2
HbO2
dHbdHb
HbO2
blood flow
HbO2
HbO2
HbO2
HbO2
HbO2HbO2
HbO2 HbO2
HbO2
HbO2HbO2
HbO2
HbO2
HbO2
[dHb]
dHb = deoxyhemoglobinHbO2 = oxyhemoglobin
capillary
blood volume
HbO2
HbO2HbO2
neuron
dHb
HbO2
HbO2
dHb
dHb
dHb
dHb
Vascular Response to Activation
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20 40 60 80
0.2
0.4
0.6
0.8
1.0
active
Echo time (TE, ms)
BO
LD
sig
na
l
rest
Typically, 1–5% signal change
Signal increases during activation (less decay)Signal change for longer delay (TE)
[dHb]
[dHb]
O2 use
bloodflow [dHb]
bloodvolume
BOLD Contrast
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20 40 60 80
0.2
0.4
0.6
0.8
1.0
active
Echo time (TE, ms)
BO
LD
sig
na
l
rest
20 40 60 80
0.2
0.4
0.6
0.8
1.0
active
Echo time (TE, ms)
BO
LD
sig
na
l
rest
difference(contrast)
Typically, 1–5% signal change
Signal increases during activation (less decay)Signal change for longer delay (TE)
O2 use
bloodflow [dHb]
bloodvolume
BOLD Contrast
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20 40 60 80
0.2
0.4
0.6
0.8
1.0
active
Echo time (TE, ms)
BO
LD
sig
na
l
rest
20 40 60 80
0.2
0.4
0.6
0.8
1.0
active
Echo time (TE, ms)
BO
LD
sig
na
l
rest
difference(contrast)
20 40 60 80
0.2
0.4
0.6
0.8
1.0
active
Echo time (TE, ms)
BO
LD
sig
na
l
rest
difference(contrast)
optimalrange
Typically, 1–5% signal change
Signal increases during activation (less decay)Signal change for longer delay (TE)
O2 use
bloodflow [dHb]
bloodvolume
BOLD Contrast
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Image artefacts worse at higher field strength
3T is currently a good tradeoff of signal vs artefacts
SNR and BOLD increase with field strength
BOLD signal and field strength (B0)
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Sources of BOLD Signal
Neuronal activity Metabolism
Blood flow
Blood volume
[dHb] BOLDsignal
Indirect measure of activity (via metabolism!)Subject’s physiological state & pathology can change
neurovascular coupling, muddying interpretation
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Stimulustiming
on
offtime
Hemodynamic response function (HRF)
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• Vascular response to activity is delayed & blurred
Stimulustiming
on
offtime
Hemodynamic response function (HRF)
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• Vascular response to activity is delayed & blurred
Stimulustiming
BOLDresponse
on
offtime
Hemodynamic response function (HRF)
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• Vascular response to activity is delayed & blurred
• Described by “hemodynamic response function”
• Limits achievable temporal resolution
• Must be included in signal model
Stimulustiming
BOLDresponse
on
offtime
Hemodynamic response function (HRF)
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Typical stimulus lasts 1–30 sRapid imaging: one image every few secondsAnatomical images take minutes to acquire!Acquire “single-shot” images (e.g., EPI)
1 23 …image TR
What is required of the scanner?
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Parameter Value Relevant points
TE(echo time)
1.5T: 60 ms3.0T: 30-40 ms7.0T: 15-20 ms
Determines functional contrast, set ≈T2*
TR(repeat time)
1–4 s HRF blurring < 1s;Poor resolution > 6s
Matrix size / Resolution
64x64 / 2-3 mm
Limited by distortion, SNR, FOV
Scan duration 2-60 mins Lower limit: sensitivity Upper limit: compliance
* Typical, not fixed!!Typical* FMRI Parameters
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• Noise: signal fluctuations leading to less robust detection with respect to statistical measures
Purely random noise(example: “thermal”)
Structured noise(example: “physiological”)
time
Confounds: Noise
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Confounds: Artefacts
Dropout Distortion
Artefacts: systematic errors that interfere with interpretability of data/images
“Ghosting”
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Source of signal dropout
BOLD contrast is based on signal dephasingBOLD imaging requires long delay (TE) for contrast
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Dephasing also occurs near air-tissue boundaries Sensitivity to BOLD effect reduces near air-tissue
boundaries
Source of signal dropout
sinus
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Long TEShort TE
Dephasing near air-tissue boundaries (e.g., sinuses)BOLD contrast coupled to signal loss (“black holes”)
Air-tissue effect is often larger than BOLD effect surrounding vessels!
BOLD Signal Dropout
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We think frequency maps to spatial location...So errors in frequency cause spatial mis-localization!
Field map
field offset local warping
EPI
Image distortion
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Non-BOLD fMRI
• BOLD depends on CBF, CBV, CMRO2
• Consider looking at these variables separately for longitudinal studies:
• CBF - Arterial Spin Labeling (ASL)
• CBV - Vascular Space Occupancy (VASO)
• CMRO2 - Calibrated BOLD
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Final Thoughts
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Final Thoughts
• Learn how different experimental parameters affect SNR and image artefacts
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Final Thoughts
• Learn how different experimental parameters affect SNR and image artefacts
• Tradeoffs: you can’t get something for nothing, but you do have options
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Final Thoughts
• Learn how different experimental parameters affect SNR and image artefacts
• Tradeoffs: you can’t get something for nothing, but you do have options
• Get to know a physicist/radiographer: get help setting up study protocols, show them your artefacts
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Final Thoughts
• Learn how different experimental parameters affect SNR and image artefacts
• Tradeoffs: you can’t get something for nothing, but you do have options
• Get to know a physicist/radiographer: get help setting up study protocols, show them your artefacts
• Quality assurance: always look at your data, even if you are running a well-tested protocol
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Acknowledgements
• Karla Miller for slides
• Previous years lecture (and more) available at www.fmrib.ox.ac.uk/~karla
• PractiCal fMRI (UC Berkeley) www.practicalfmri.blogspot.co.uk
• Animations: Spinbench
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Thank you!
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