Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof...

14
May 24, 2018 Introduction to Genomics Malvika Pillai

Transcript of Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof...

Page 1: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

May24,2018

IntroductiontoGenomics

Malvika Pillai

Page 2: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

• WhatisGenomics?• GenomeSequencing• Genotyping

OutlineforIntroductiontoGenomics

Page 3: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

WhatisGenomics?

Page 4: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

Collection ofinformation

Subsetofinformationtobeexpressed

Problem

Page 5: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

DefinitionofGenomics

Geno

mics

Functional

Comparative

Structural

etc.

• Large-scalestudyofgroupsofgeneswithinoneorganismorbetweenmultipleorganisms

Page 6: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

GenomeSequencing

Page 7: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

>NC_000017.11:c43125483-43044295 Homosapienschromosome17,GRCh38.p12PrimaryAssemblyGTACCTTGATTTCGTATTCTGAGAGGCTGCTGCTTAGCGGTAGCCCCTTGGTTTCCGTGGCAACGGAAAAGCGCGGGAATTACAGATAAATTAAAACTGCGACTGCGCGGCGTGAGCTCGCTGAGACTTCCTGGACGGGGGACAGGCTGTGGGGTTTCTCAGATAACTGGGCCCCTGCGCTCAGGAGGCCTTCACCCTCTGCTCTGGGTAAAGGTAGTAGAGTCCCGGGAAAGGGACAGGGGGCCCAAGTGATGCTCTGGGGTACTGGCGTGGGAGAGTGGATTTCCGAAGCTGACAGATGGGTATTCTTTGACGGGGGGTAGGGGCGGAACCTGAGAGGCGTAAGGCGTTGTGAACCCTGGGGAGGGGGGCAGTTTGTAGGTCGCGAGGGAAGCGCTGAGGATCAGGAAGGGGGCACTGAGTGTCCGTGGGGGAATCCTCGTGATAGGAACTGGAATATGCCTTGAGGGGGACACTATGTCTTTAAAAACGTCGGCTGGTCATGAGGTCAGGAGTTCCAGACCAGCCTGACCAACGTGGTGAAACTCCGTCTCTACTAAAAATACAAAAATTAGCCGGGCGTGGTGCCGCTCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTAGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATCGCGCCATTGCACTCCAGCCTGGGCGACAGAGCGAGACTGTCTCAAAACAAAACAAAACAAAACAAAACAAAAAACACCGGCTGGTATGTATGAGAGGATGGGACCTTGTGGAAGAAGAGGTGCCAGGAATATGTCTGGGAAGGGGAGGAGACAGGATTTTGTGGGAGGGAGAACTTAAGAACTGGATCCATTTGCGCCATTGAGAAAGCGCAAGAGGGAAGTAGAGGAGCGTCAGTAGTAACAGATGCTGCCGGCAGGGATGTGCTTGAGGAGGATCCAGAGATGAGAGCAGGTCACTGGGAAAGGTTAGGGGCGGGGAGGCCTTGATTGGTGTTGGTTTGGTCGTTGTTGATTTTGGTTTTATGCAAGAAAAAGAAAACAACCAGAAACATTGGAGAAAGCTAAGGCTACCACCACCTACCCGGTCAGTCACTCCTCTGTAGCTTTCTCTTTCTT

Whatisagenome?

Page 8: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

• Sangersequencing• NextGenerationSequencing(NGS)– IlluminaSequencingbySynthesis

Howdowesequenceagenome?

Page 9: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional
Page 10: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

Genotyping

Page 11: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

Genotyping

Page 12: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

AnyQuestions?

Page 13: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

IntroductiontoGenomics:Demo+Hands-OnExercise

NextClass

Page 14: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

• MutatingRNAinMatlab– VisualizingRNAfolds– Comparingmutatedstrandstowildtypestrands

Demo


Transmission of genetic information Genetics and genomics for 3 rd year Dentistry students 13.02.2015.

Transmission of genetic information Genetics and genomics for 3 rd year Dentistry students 13.02.2015.

23andMe, Pathway Genomics, Complete Genomics, Counsyl | Company Showdown

23andMe, Pathway Genomics, Complete Genomics, Counsyl | Company Showdown

Internet Archive · 2015. 3. 17. · SALENUMBER2015 PUBLICEXHIBITIONFROMSATURDAY,DECEMBERTWELFTH AFINE COLLECTIONOF CHINESE CARVEDJADES &OTHERPRECIOUS HARDSTONES RARENECKLACES,PENDANTS&OTHER

Internet Archive · 2015. 3. 17. · SALENUMBER2015 PUBLICEXHIBITIONFROMSATURDAY,DECEMBERTWELFTH AFINE COLLECTIONOF CHINESE CARVEDJADES &OTHERPRECIOUS HARDSTONES RARENECKLACES,PENDANTS&OTHER

Comparitive genomics

Comparitive genomics

Genomics in Society: Genomics, Preventive Medicine, and Society

Genomics in Society: Genomics, Preventive Medicine, and Society

Genomics in Medicine: An Introduction to Genomics: Breast Cancer

Genomics in Medicine: An Introduction to Genomics: Breast Cancer

Evolutionary Genomics of Lactic Acid BacteriaEvolutionary Genomics of Lactic Acid Bacteria Kira S. Makarova* and Eugene V. Koonin National Center for Biotechnology Information, National

Evolutionary Genomics of Lactic Acid BacteriaEvolutionary Genomics of Lactic Acid Bacteria Kira S. Makarova* and Eugene V. Koonin National Center for Biotechnology Information, National

Chapter 15 - sbs.utexas.edu · Chapter 15 Microbial Genomics. 2 Genomics • study of molecular organization of genomes, their information content, and gene products they encode •

Chapter 15 - sbs.utexas.edu · Chapter 15 Microbial Genomics. 2 Genomics • study of molecular organization of genomes, their information content, and gene products they encode •

Google Genomics Documentation - Read the Docsmedia.readthedocs.org/pdf/google-genomics/latest/google-genomics… · Google Genomics Documentation, Release v1 The 1000 Genomes Project

Google Genomics Documentation - Read the Docsmedia.readthedocs.org/pdf/google-genomics/latest/google-genomics… · Google Genomics Documentation, Release v1 The 1000 Genomes Project

 · Web viewGenetics and Genomics. Genetics and Genomics. Genetics and Genomics. Genetics and Genomics. Cell cycle, divisions, gametogenesis. Mutations and polymorphisms. Cytogenetics.

 · Web viewGenetics and Genomics. Genetics and Genomics. Genetics and Genomics. Genetics and Genomics. Cell cycle, divisions, gametogenesis. Mutations and polymorphisms. Cytogenetics.

Genomics study of molecular organization of genomes, their information content, and gene products they encode divided into three areas –structural genomics.

Genomics study of molecular organization of genomes, their information content, and gene products they encode divided into three areas –structural genomics.

Pathogenomics How this project began: Ann Rose - take advantage of DNA sequence information - genomics Julian Davies - use the information to understand.

Pathogenomics How this project began: Ann Rose - take advantage of DNA sequence information - genomics Julian Davies - use the information to understand.

Environmental Genomics

Environmental Genomics

Get What They Are Worth - Angus Journal Leachman 11_14 AJ.pdf · Association, Lauren Hyde said the organization jumped on the genomics bandwagon 18 months ago. Genomics information

Get What They Are Worth - Angus Journal Leachman 11_14 AJ.pdf · Association, Lauren Hyde said the organization jumped on the genomics bandwagon 18 months ago. Genomics information

Genomics report

Genomics report

Structural Genomics, ISGO, and Structural Genomics Task Forces Open ISGO Structural Genomics Task Force Meeting ISGO International Structural Genomics.

Structural Genomics, ISGO, and Structural Genomics Task Forces Open ISGO Structural Genomics Task Force Meeting ISGO International Structural Genomics.

Comparative genomics

Comparative genomics

Personal Genomics Carrie Iwema, PhD, MLS, AHIP 19 th March 2014 Molecular Biology Information Service.

Personal Genomics Carrie Iwema, PhD, MLS, AHIP 19 th March 2014 Molecular Biology Information Service.

RICE GENOMICS: Progress and prospects. What is genomics? The genome of a plant, animal or microbe is the totality of its genetic information including.

RICE GENOMICS: Progress and prospects. What is genomics? The genome of a plant, animal or microbe is the totality of its genetic information including.

Entropy and Information - Pompeu Fabra Universityregulatorygenomics.upf.edu › courses › Master_AGB › 2...Entropy and Information Eduardo Eyras Computational Genomics Pompeu Fabra

Entropy and Information - Pompeu Fabra Universityregulatorygenomics.upf.edu › courses › Master_AGB › 2...Entropy and Information Eduardo Eyras Computational Genomics Pompeu Fabra