Intro-BIOL318 Immunology Instructor: Dr. Kathy Szick-Miranda Office: Science I 316 Phone: 654-6165
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Intro-BIOL318 Immunology Instructor: Dr. Kathy Szick-Miranda Office: Science I 316 Phone: 654-6165 Email: [email protected] Web: www.csub.edu/~kszick_miranda Office hours: M 10-12; T 3:30-5; W 10- 11:30 Lecture and Discussion: T R 10:00- 11:40am, Sci II 180
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Intro-BIOL318 Immunology Assignment Point Values: Exam I100pts Exam II 100pts Final Exam (Exam III)100pts Quizzes (top 5 scores) 50pts TOTAL 350pts
Transcript of Intro-BIOL318 Immunology Instructor: Dr. Kathy Szick-Miranda Office: Science I 316 Phone: 654-6165
Intro-BIOL318 Immunology
Instructor: Dr. Kathy Szick-MirandaOffice: Science I 316Phone: 654-6165Email: [email protected] Web: www.csub.edu/~kszick_mirandaOffice hours: M 10-12; T 3:30-5; W 10-11:30Lecture and Discussion: T R 10:00-11:40am, Sci II 180
Intro-BIOL318 ImmunologyCourse Objectives: Upon completion of this course students will be expected to: •Describe the various cells and organs of the immune system, including the role of each during the immune response.•Compare and contrast innate and acquired immunity, including their specific components and effector mechanisms.•Describe antigens and antibodies and their interactions.•Discuss the immune response to specific pathogens.
Intro-BIOL318 Immunology
Assignment Point Values:Exam I 100ptsExam II 100ptsFinal Exam (Exam III) 100ptsQuizzes (top 5 scores) 50ptsTOTAL 350pts
Historical PerspectiveImmunity - state of protection from an infectious disease.
430 BC – Greek historian Thucydides - Athenian plague
15th century – Chinese attempts to induce immunity
1718 – Mary Wortley Montagu – innoculated her children
1798 – Edward Jenner – milkmaids and cowpox/smallpox
Historical Perspective
early 1880’s – Cholera and chickens
Attenuation hypothesis
1881 – Testing the hypothesis with anthrax and sheep
1885 – Rabies vaccine
Louis Pasteur
Historical Perspective1890 - Behring and Kitasato – link serum to immunity
1883 – Metchnikoff – links cells (phagocytes) to immunity
early 1900’s – many functions of immune serum
1930’s – Kabat - immunoglobulin/antibodies
1950’s – Glick – two types of lymphocytes
Historical Perspective
1900 – Paul Ehrlich – Selective theory
1950’s – Jerne, Talmadge and Burnet – clonal selection theory
Historical Perspective
Infection and Immunitypathogens – organisms causing disease
pathogenesis – the means by which disease-causing organisms attach a host.
Innate and Adaptive Immunity
Innate
1st line of defense
Non-specific mechanisms
Phagocytes and recognition molecules
Adaptive
2nd line of defense
Highly specific mechanisms
Lymphocytes, antigen specific
receptors, antibodies
Components of Adaptive Immunity
T Lymphocytes
Innate and Adaptive Immunity
Innate and Adaptive Immunity
Immune Dysfunction
Allergies and asthma
Graft rejection
Autoimmune disease
Immunodeficiency
