Intestinal tuberculosis and tuberculous...
Transcript of Intestinal tuberculosis and tuberculous...
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GAO Hong Department of Gastroenterology, Zhongshan Hospital
Fudan University
Intestinal tuberculosis and
tuberculous peritonitis
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Objectives
1. To master the clinical manifestations,
complications, diagnosis and differential
diagnosis.
2. To master the diagnosis and differential
diagnosis of ascites, especially SAAG and
ADA;
3. To be familiar with the pathogenesis,
classification, prevalence and the therapy
of the diseases.
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Pathogen
• Mycobacterium tuberculosis is the pathogen in most
cases.
• Mycobacterium bovis in some parts of the world with
no pasteurization of milk.
• Mycobacterium avium intracellulare has become a
major pathogen in HIV patients.
• M. africanum, M. microti, and M. canetti
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Epidemiology
• Second infectious disease in China
• The epidemic is being accelerated by co-
infection with HIV and compounded by multi-
drug resistant TB;
• The incidence of GI TB is unknown;
• 20% pulmonary TB cases have extra-
pulmonary TB including GI TB;
• 15-20% GI TB case have pulmonary TB.
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• Following infection, the incubation period
of TB range from a few weeks to a
lifetime.
Comstock et al. American Journal of
Epidemiology 99:131-138
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Intestinal Tuberculosis
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Infective Route
• Ingestion of infected food or milk
• Swallowing of infected sputum from active
lung disease
• Hematogenous spread from active
pulmonary TB
• Direct spread from adjacent viscera
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Site of disease
TB can involve any region of GI tract;
• Ileum and cecum
• Ascending colon
• Jejunum
• Duodenum
• Stomach
• Esophagus
• Sigmoid colon
• rectum
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Why is ileocecal region?
• Its richness of lymphoid tissue
• Increased absorption rate
• Relative stasis
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Infection - Immunity
Pathogenesis of TB:
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FORMS OF GI TB
Ulceroconstrictive
60% of patients
Highly virulent
Mostly small Intestinal
Hypertrophic
10% of patients
Chronic
Mostly Ileocoecal
Mixed 30% of patients
(Howell & Knapton, 1964)
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Three types of intestinal tuberculosis
• Ulcerative lesion(common)
• Hypertrophic lesion
• Ulcerohypertrophic lesions
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T.B. transverse girdle ulcer small intestine
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Sub mucosal muscular and subserous granulomas
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Pathology
• Bowel wall-thicken
• Inflammatory mass
• Multiple transverse, circumferential ulcer,
often with normal segments in between
• Mucosa-hyperemic, cobblestoned,
edematous, ulcerated
• Serosal-tubercles;lymph nodes-enlarged
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The approach to the subject
was directed to these main points.
• Country and continent of origin.
• Age
• Gender
• Associated HIV infection
• Associated pulmonary disease
• Constitutional signs and symptoms
• Signs and symptoms related to the site of
involvement in the G.I. tract
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Manifestation
• Non-specific, usually insidious
• Abdominal pain(80-90%), distension,
• Diarrhea:mucoid,liquid to semisolid
stools,rarely containing pus or blood
• abdominal mass
• Fever, weight loss, night sweat
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Complication
• Intestinal hemorrhage
• Perforation
• Obstruction
• Fistula formation
• malabsorption
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Local manifestations of ileocoecal cases
(n= 520)
30.8%
16.7%
9.2%
8.5%
2.0%
0% 5% 10% 15% 20% 25% 30% 35%
pain
diarrhea
distention
mass
malabsorption
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Local manifestations of colorectal cases
(n= 463)
39.1%
21.8%
12.1%
9.0%
0% 5% 10% 15% 20% 25% 30% 35% 40% 45%
pain
rectal bleeding
mass
distention
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Local manifestations of esophagus cases
(n= 86)
57.0%
32.6%
12.8%
2.3%
1.2%
1.2%
1.2%
0% 10% 20% 30% 40% 50% 60%
Dysphagia
Fistula
Haematemesis
Esophageal diverticula
Epigastric pain
Free mediastinal air
Mediastinitis
Cairo University
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Local manifestations of gastroduodenal
cases (n= 42)
52.4%
26.2%
19.0%
11.9%
2.4%
0% 10% 20% 30% 40% 50% 60%
Ulcer dyspepsia
Outlet obstruction
Mass
Haematemesis
Fistula
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Local manifestations of small intestinal cases
(n= 112)
81.3%
20.5%
11.6%
6.3%
4.5%
1.8%
0.9%
0.9%
0% 10% 20% 30% 40% 50% 60% 70% 80% 90%
Perforation
Ascitis
Obstruction
Abd.pain
Ulcer
Abd.mass
Hge
Fistula
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Laboratory finding
• Blood routine test
-mild anemia
-normal white blood cell count
-lymphopenia or lymphocytosis
• High erythrocyte sedimentation rate
• Tuberculin skin tests
-PPD test, less helpful
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Laboratory findings
• Identification of organism in tissues
• acid-fast stain
• culture of the excised tissue
• PCR assay
• T-spot test
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Radiological examination
• Chest X-ray
-abnormality(37-57%)
-active pulmonary tuberculosis
• Plain X-ray films
-diffuse abdominal calcifications
• Barium studies
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X-ray
• A thicken bowel wall with distortion of
the mucosal folds, ulceration,bowel
stenosis, and pseudopolyps
formation
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• Stierlin Sign
Radiologic examination
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Radiologic examination
• Fleischner's sign
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hypertrophic type
Radiologic examination
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Radiologic examination
ulcerohypertrophic type
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CT
• Thickening of the ileocecal valve and
medial wall of cecum
• Massive lymphadenopathy with
central necrosis
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Colonoscopy ascending colon(ulcerative lesion)
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Hypertrophic lesion
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Ileum and cecum:ulcerohypertrophic
Ulcer
Proliferation
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Diagnoisis
Histrory
Clinical features
X-ray
PPD
Anti-tuberculosis therapy
Colonoscopy with biopsy
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Differential diagnosis
• Crohn’s disease
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• Carcinoma
• Amebiasis
• Schistosomiasis
• Syphilis and lymphogranuloma
• Gastrointestinal lymphoma
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Treatment
• General: rest and nutrition
• Standard anti-tuberculosis treatment
• Ciprofloxacin, oxfloxacin,
fluoroquinolone
• Corticosteroids
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Surgery
• Assist diagnosis
• Treat complications
-bowel obstruction
-perforation
-fistulae
-hamorrhage
-abscess perforation
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Tuberculous peritonitis
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Infective route
• Direct spread from (ruptured) lymph
nodes and intraabdomininal organs
• Hematogenous seeding
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pathology
• Multiple small, hard, raised, whitish
tubercles studding the peritoneum
• A cecal tuberculoma, matterd lymph
nodes, or omental involvement may
form a palpable mass
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Manifestation
• Systemic:
– Fever, night sweat, weight loss
• local:
– Abdominal pain
– Abdominal distension-ascites
– Diarrhea
– Nausea and vomiting
– Abdominal mass
– Doughy abdomen
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Local manifestations of peritonitis cases
(n= 881)
90.6%
59.9%
23.7%
3.4%
3.4%
2.0%
1.0%
0% 20% 40% 60% 80% 100%
ascitis
pain
mass
lymphadenopathy
jaundice
distention
diarrhoea
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Laboratory finding
• Blood routine test
• ESR
• PPD test
• Test of ascites!!!
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Paracentesis
• Exudative fluid
• High protein content
• Leukocytosis(lymphocytic)
• Adenosine deaminase(ADA) increases
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• Gravity >1.016
• SAAG<11g/L
• Protein: >30g/L
• White cell: >500×106/L with lymphocyte 40-
92%
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Abdominal ultrasound
• Quick and inexpensive
• Detecting subclinical ascites and
abdominal lymphadenopathy
• Assistant paracentesis
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Radiology
• Chest X-ray
• CT
-detecting lymphadenopathy
-diffuse thickening of peritoneum
-help differentiation
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laparoscopy
• Correct diagnosis 72-95%
• Laparoscopic appearance at
operation is more accurate than
subsequent histology or
microbiological culture
• Biopsy
• Contraindication-extensive adhesion
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Laparoscopy
• Thickened. Hyperaemic, occasionally
hemorrhagic, inflamed peritoneum
• Diffuse, white-yellowish uniform (3-
5mm) tubercles deposits on
peritoneum, omentum and organs
• Adhesions between organs and
peritoneum
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Typical tubercles
• Caseating granulomas epitheloid and
with langerhans cells
• Chronic inflammation
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Peritoneal T.B.
Laparoscopy
Hunter, Cairo University T.B. peritonitis granulomata
with fibrosis in the
omentum
Makram Milad
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Calcified T.B lymph nodes
C.T. scan
T.B. Peritoneal adhesions
Ultrasonography Peritoneal T.B with adhesions
Laparoscopy
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Diagnosis
• History
• Clinical features
• Ascites
• X-ray
• PPD
• Diagnostic treatment
• Laparoscopy and biopsy
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Differential diagnosis
• Ascites:
– malignant tumor
– cirrhosis
– Meigs’ syndrome
– Budd-Chiari syndrome
– constrictive pericarditis, etc.
• Abdominal mass: tumor, crohn’s disease
• Abdominal pain
• Fever
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treatment
• General treatment: rest and nutrition
• Standard anti-tuberculosis
chemotherapy
• Abdominal paracentesis
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Key Concepts for GI tuberculosis
Sites: any region of the gastrointestinal
tract. The most frequent sites are the ileum
and cecum.
Histological lesion: caseating granulomas.
The common symptoms and signs:
abdominal pain, weight loss, fever,
diarrhea or constipation, and blood in the
stool.
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The definitive diagnosis is made by identification
of the organism in tissue, either by direct
visualization with an acid-fast stain, by culture of
the excised tissue, or by a polymerase chain
reaction (PCR) assay.
Standard anti-tuberculosis treatment gives a high
cure rate.
Key Concepts for GI tuberculosis
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Key points for tuberculous peritonitis
Manifestions include low-grade fever, abdominal pain, anorexia, weight loss, and ascites.
The peritoneal fluid characteristics: - protein concentration above 3 0g/L;
- SAAG ≤11 g/L;
- lymphocyte-predominant leukocytosis;
- elevated ADA activity.
Characteristic peritoneal nodules in laparoscopy in >90% of patients.
Treatment is by standard anti-tuberculosis drugs.
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CONCLUSION
• The disease is still and will remain a
serious public health threat worldwide
• HIV infection is a main risk factor.
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(Bouma et al., 1997)
G.I. TUBERCULOSIS, A FINAL WORD
of Abdominal Tuberculosis
Be aware
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