بسم ال الرحمن الرحيم

By

Mohamed El-SawyProf. in Pediatric Department

Faculty of Medicine- Ain Shams University

INTERSEX

Undifferntiated Gonad

Wolffian duct system

Mullerian duct system

GONADAL DEVELOPMENTINTERNAL GENITALIA

7-8 weeks

External Genitalia

Normal AbnormalIntersexHypogenitalism

TruePseudo: Female

Male

Intersex

True Hermaphroditism

•Definition

•Types

•Chromosomal Pattern

Defect of Testicular DifferentiationDefect of Testicular Differentiation

Absent HY antigen

Target Tissue Resistance

Embryonic Testicular Regression Syndrome

Bilateral Anorchia

DyshormonogenesisDyshormonogenesis

Uterine Hernia SyndromeUterine Hernia Syndrome

Defect of Androgen ActionDefect of Androgen Action

Testicular Feminization

5-Alpha-Reductase Deficiency

Partial T.FPartial T.F..

Partial T.FPartial T.F..

Partial T.FPartial T.F..

55--αα Reductase Deficiency Reductase Deficiency

55--αα Reductase Deficiency Reductase Deficiency

DSD TEAMDSD TEAM

MultidisciplinaryEndocrine

Genetics

Urology

Psychology/Psychiatry

Religious counseling

Gynecologist

SEX ASSIGNMENTSEX ASSIGNMENT

Actual Anatomy

Available surgical intervention

Functionl Endocrinology

Chromosomal Pattern

Non functioning female better than non functioning male

Prader Willi Syndrome

Pure XX Gonadal DysgenesisPure XX Gonadal Dysgenesis

Thank You