International Forum of Biomedical Materials

— Biomaterials Interfaces and Nanobiomaterials

Aug 1 – 3, 2016, Hangzhou, China

During the past decades, significant developments in the field of biomedical

materials have been achieved. The International Forum of Biomedical

Materials (IFBM), which is held at Hangzhou every 2 years since 2012,

aims to provide a unique forum for communication and discussion in

fundamental science, technology and application of the biomedical materials,

by bringing together leading international scientists and engineers. One of

the important aims of IFBM is to promote the scientific and technical

growth in this field..

You are highly welcome to participate in this forum!

3rd circular

Registration Information

◆ Registration Fee

Regular participant: 300$ (2000RMB)

Student (with certificate): 170$ (1000 RMB)

◆ Venue and Accommodation Huagang HNA Resort (Hua Gang Hai Hang. 花港海航酒店)

No. 1 Yang Gong Di, West Lake District - West Lake Scenic Area, Hangzhou, China

http://www.hz-haihang.com/

From Hangzhou Xiaoshan Airport: ~ 150 RMB

From Hangzhou Railway Station: ~ 30 RMB

From Hangzhou East Railway Station: ~ 60 RMB

◆ Transportation (TAXI)

* The registration fee shall be paid by cash on site. Credit card is not acceptable.

* The registration fee for keynote and invited speakers are exempted.

Participant from industry: 5000 RMB

(including the Workshop and booth)

Single room/Double room: 450 RMB/day (including breakfast and free internet)

E-mail: biomat@zju.edu.cn Tel/Fax: 86-571-8795-1108

Contact

Sponsors

The Natural Science Foundation of China

The Key Science Technology Innovation Team of Zhejiang Province

Zhejiang University

Concurrent I: Nanomaterials & nanomedicine III

(Yun Xi Ting, 3rd floor)

Concurrent II: Materials for regenerative medicine III

(Gui Yu Ting, 3rd floor)

Concurrent III: Surface and interface of biomaterials III

(Huan Bi Ting, 3rd floor)

Chair: Mingyuan Gao Chair: Dong-an Wang Chair: Jian Ji

8:30-8:55

To be confirmed

Xiqun Jiang (Keynote)

Nanjing University, China

Multifunctional stem cell delivery systems for ischemic limb

regeneration

Jianjun Guan (Keynote) The Ohio State University, USA

Cationic polymers for antimicrobial effects for various applications

Chan Bee Eng Mary (Keynote)

Nanyang Technological University, Singapore

8:55-9:20

Multiscale biomaterials for enriching and

eliminating cancer stem cells

Xiaoming He (Keynote)

The Ohio State University, USA

Bioskiving: bioinspired fabrication of nanostructures from

tissue slices

Qiaobing Xu (Keynote)

Tufts University, USA

Multivalent Ephrin-B2 biomaterials to control

arterial venous differentiation of pluripotent stem cells.

Guohao Dai (Keynote)

Rensselaer Polytechnic Institute, USA

9:20-9:40

Biodegradable polymer nanoparticles as carriers

for lung drug delivery

Nazrul Islam (Invited)

Queensland University of Technology, Australia

The Surface functionalization of polypropylene and its

antiadhesion efficacy in experimental hernia repair

Tianzhu Zhang (Invited) Southeast University, China

Mediated cell migration and adhesion on structured substrates

Jun Fu (Invited)

Ningbo Institute of Materials Technology and Engineering, CAS,

China

9:40-10:00

Compilation of AIE derivatives into polyplex for

pursuit of improved colloidal stability and utility

in tracing intracellular DNA trafficking

Hui Gao (Invited)

Tianjin University of Technology, China

Keratin based wound dressing and drug carrier

Jiang Yuan (Invited)

Nanjing Normal University, China

Multifunctional and universal proteinaceous coating inspired by

amyloid-mediated bioadhesion

Peng Yang (Invited)

Shaanxi Normal University, China

10:00-10:30 Coffee break/Poster session

Chair: Xiqun Jiang Chair: Jianjun Guan Chair: Chan Bee Eng Mary

10:30-10:55

Nanoprobes for tumor theranostics

Mingyuan Gao (Keynote)

Institute of Chemistry, CAS , China

Microspheres/hydrogel composites for tissue engineering

applications

Dong-an Wang (Keynote)

Nanyang Technological University, Singapore

Bionanointerface: from cell membrane mimic to protein mimic

Jian Ji (Keynote)

Zhejiang University, China

10:55-11:20

To be confirmed

Xingyu Jiang (Keynote)

National Center for NanoScience and Technology,

China

Functional biomaterials for musculoskeletal tissue

regeneration

Liming Bian (Keynote)

The Chinese University of Hong Kong, China

Interfacial soft matters for bioinspired lubrication

Feng Zhou (Keynote)

Lanzhou Institute of Chemical Physics, CAS, China

11:20-11:40

The morphology effect of polycation

functionalized nanoparticles on gene transfection

Nana Zhao (Invited)

Beijing University of Chemical Technology, China

11:20-11:45:

Improving corrosion resistance and biocompatibility of

WE43 magnesium alloy by custom made dual plasma

implantation

Kelvin Yeung (Keynote)

The University of Hong Kong, China

Patterning of biomaterials surface to selectively react with blood

Qiang Shi (Invited) Changchun Institute of Applied Chemistry, CAS, China

11:40-12:00 To be confirmed

Zhengwei Mao (Invited)

Zhejiang University, China

Cell sheet harvesting from light-responsive surfaces

Kui Cheng (Invited)

Zhejiang University, China

12:00-14:00 Lunch (Western restaurant, 1st floor)

Au

g. 3

Corresponding author Tel:+852 22554654; fax:+852 28174392 Email address: wkkyeung@hku.hk

Improving corrosion resistance and biocompatibility of WE43 magnesium alloy by custom made dual plasma implantation

ZhengjieLina,b, YingZhaoc, Hoi Man Wonga,b, Kenneth M C Cheunga, PaulK.Chud, Kelvin W.K. Yeunga,b＊ aDepartment of Orthopaedics and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong

bShenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma, The University of Hong Kong Shenzhen Hospital, 1 Haiyuan 1st Road, FutianDistract, Shenzhen, China

c Center for Human Tissues and Organs Degeneration, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

dDepartment of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong

* Corresponding author’s e-mail address: wkkyeung@hku.hk INTRODUCTION: Magnesium alloy is a potential candidate for degradable orthopaedic implantation due to its degradability. However, rapid corrosion and subsequent severe hydrogen release under in vivo conditions limit its clinical application. Therefore, various methods e.g. alloying, coating, and heat treatment have been applied to reinforce its corrosion property. In this study, we have developed titanium and oxygen dual plasma immersion ion implantation (PIII) [1] technique to improve the corrosion resistance and biocompatibility of WE43 alloy. METHODS: The casted WE43 alloy was treated by titanium and oxygen dual implantation. For characterization of PIII-treated WE43 alloy, the atomic force microscope (AFM) and X-ray photoelectron spectroscopy (XPS) were conducted to investigate surface chemical states and morphology of the PIII-treated WE43 alloy. In order to systematically examine corrosion resistance of the untreated and PIII-treated alloys, immersion and electrochemical tests in the simulated body fluid(SBF) at 37℃ were also carried out. The biocompatibility of PIII-treated WE43 alloy was evaluated by MTT,ALP assays and cell attachment analysis cultured with mouse osteoblastic cells. RESULTS& DISCUSSION: The XPS and AFM results indicated that the surface of WE43 magnesium alloy appeared a dense TiO2 protective film with the thickness of about 120nm created by titanium and oxygen dual implantation. The electrochemical tests in SBF showed that the PIII-treated WE43 alloy exhibited excellent performance of corrosion resistance. Its electrochemical impedance increased eighty times approximately, while corrosion density sharply dropped in the untreated group. Moreover, the TiO2

protective film could still reduce corrosion and the subsequent Mg ion release effectively in comparison with the untreated alloy after three days of immersion in SBF. It was an evidence that the created dense TiO2

film could suppress rapid corrosion of WE43 magnesium alloys. The WE43 alloy treated by Ti &O dual implantation exhibited achieved higher cell viability and ALP activity. Furthermore, the morphology of cells flattened and more F-actins were observed on the surface of PIII-treated WE43 alloy while culturing with MC3T3-E1 pre-osteoblasts, indicating that the cyto-compatibility of WE43 alloys can be significantly improved by titanium and oxygen dual PIII treatment. CONCLUSIONS: In summary, the corrosion resistance and cyto-biocompatibility of WE43 magnesium alloys can be significantly enhanced by Ti and O dual plasma ion immersion implantation. It is expected that the PIII-treated WE43 alloy may potentially apply for the management of large bone segmental defect after systematic in vivo pre-clinical analyses. REFERENCES:1H.M.Wong.Biomaterials.2013;34:7016-7032. ACKNOWLEDGEMENTS: This work was financially supported by National Natural Science Foundation of China No. 31370957 and Hong Kong Research Grant Council General Research Fund (#718913).