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International Conference on BioElectronics, BioSensors,

BioMedical Devices, BioMEMS/NEMS and Applications

2012 (Bio4Apps 2012) National University of Singapore

Singapore, Nov. 19 and 20, 2012

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In view of the significant progress in different fields of biotechnology enabled by cornerstone technologies such as electronics, sensors, and micro/nanotechnology, technology fusion with a focus in emerging markets and applications will create disruptive biotechnology. To foster communication among leading researchers in the spirit of “biotechnology for applications (Bio for Apps)”, the 1st International Conference on BioElectronics, BioSensors, BioMedical Devices, BioMEMS/NEMS and Applications 2012 (Bio4Apps 2012) will take place on November 19-20 at the National University of Singapore, Singapore. This conference will create a platform for researchers all over the world to convene, report and exchange results in areas of bioelectronics, biosensors, biomedical devices, and bioMEMS/NEMS, with a strong emphasis on commercialization and applications. The conference offers several keynotes and invited talks, as well as contributed oral presentations and posters. The major areas in biological and biomedical applications solicited and expected at this conference include, but are not limited to:

BioMedical Devices Bio-imaging technology Bio-compatible materials

and packaging Implantable medical devices Prosthesis and Neural

probes Surgical robots

BioElectronics Biomedical signal processing Body area sensor networks Circuits for biomedical

applications/devices Flexible electronics Implantable electronics

BioSensors Lab-on-chip Miniaturized diagnostic

medical devices Novel bioelectric sensing

methods Nanophotonics/THz sensing Physiological monitoring

BioMEMS/NEMS Drug delivery Energy harvesting technology MEMS/NEMS for biomedical

applications Microfluidics for biomedical

applications

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SPONSORS

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Honorary Chair:

Prof./Dr. Dim-Lee Kwong Executive Director Institute of Microelectronics (IME), Agency for Science, Technology and Research, Singapore Dim-Lee Kwong received the B.S. degree in physics and the M.S. degree in nuclear engineering from National Tsing Hua University, Hsinchu, Taiwan, in 1977 and 1979, respectively.

He received the Ph.D. degree in electrical engineering from Rice University, Houston, TX, in 1982. He is the Executive Director of the Institute of Microelectronics (IME), Agency for Science, Technology and Research, Singapore, a Professor of electrical and computer engineering with the National University of Singapore, Singapore, and an Adjunct Professor of electrical and computer engineering with the University of Texas at Austin. He was the Earl N. and Margaret Brans field Endowed Professor with the University of Texas at Austin from 1990 to 2007 and the Temasek Professor with the National University of Singapore from 2001to 2004. He is the author of more than 1000 refereed archival publications (560 journal and 470 conference proceedings), has presented more than 80 invited talks at international conferences, and is the holder of more than 25 U.S. patents. He was the Founder of Rapro Technology Inc., in 1986, and Micro Integration Corporation, in 1988, and has been a Consultant to government research laboratories, semiconductor IC manufacturers, and materials and equipment suppliers in the U.S. and overseas. More than 55 students received their Ph.D. degrees under his supervision. As an Executive Director of IME, he develops and implements IME’s multidisciplinary and multifaceted R&D strategy and research programs that are substantially driven by commercial applications as the end goal. He leads interdisciplinary teams of semiconductor technology, photonics, bioscience, radio frequency and mixed signal IC design, and advanced packaging, together with strategic industrial and clinical partners, to develop leading-edge disruptive technologies for Si photonics, green electronics, 3-D IC, microelectromechanical systems, and biomedical applications. Prof. Kwong was the recipient of the IBM Faculty Award from 1984 to 1986,the Semiconductor Research Corporation Inventor Awards from 1993 to 1994,the General Motor Foundation Fellowship from 1992 to 1995, the Halliburton Foundation Excellent Teaching Award in 1994, the Engineering Foundation Award in 1995, the IEEE George Smith Award in 2007, and the 2011 IEEE Frederik Philips Award with the following citation: “For leadership in silicon technology and excellence in the management of microelectronics R&D.”

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General Chair: Singapore –

Yong Lian Provost’s Chair Professor Area Director, Integrated Circuits & Embedded Systems Department of Electrical and Computer Engineering, National University of Singapore, Singapore

LIAN Yong is a Provost’s Chair Professor and Area Director of Integrated Circuits and Embedded Systems in the Department of Electrical & Computer Engineering, NUS. He is the Founder of ClearBridge VitalSigns Pte Ltd, a start-up for wireless wearable biomedical devices. His research interests include low power circuit techniques, signal processing, and wireless miniaturised biomedical devices. He is the recipient of the 1996 IEEE Circuits and Systems (CAS) Society's Guillemin-Cauer Award, the 2008 Multimedia Communications Best Paper Award from the IEEE Communications, and many other awards. He is also a recipient of the 2009 and 2010 NUS Annual Teaching Excellence Awards. Dr. Lian is the Editor-in-Chief of the IEEE Transactions on Circuits and Systems II, Steering Committee Member of the IEEE Transactions on Biomedical Circuits and Systems (BioCAS), Chair of DSP Technical Committee of the IEEE CAS Society. He was the Vice President for Asia Pacific Region of the IEEE CAS Society from 2007 to 2008, Chair of the BioCAS Technical Committee of the IEEE CAS Society (2007-2009), the Distinguished Lecturer of the IEEE CAS Society (2004-2005). Dr. Lian is a Fellow of IEEE.

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Steering Committee Chair:

Kohji Mitsubayashi Professor Dept. of Biomedical Devices and Instrumentation, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University Kohji Mitsubayashi received the degree of B.E. (1983) and

M.E. (1985) in Mechanical Engineering from Toyohashi University of Technology, and the Ph.D. degree in Interdisciplinary Course on Advanced Science and Technology from The University of Tokyo (1994). He worked as a company researcher at DENSO Corporation (1985-1998). He was an associate Professor in the Department of Electrical Engineering (1998-2001) and Information sciences (2001-2003) at Tokai University. Since 2003, he has been a Professor in the Department of Biomedical Devices and Instrumentation at Tokyo Medical and Dental University. His research interests includes wearable biosensors with Soft-MEMS techniques for non-invasive biochemical-monitoring, biochemical gas sensors (Bio-Sniffer) and gas visualization system for human odor and halitosis analysis, novel artificial organs (hands, pancreas) with “Organic Engine” converting from chemical to mechanical energy, etc.

Steering Committee Members: (In alphabet sequence) Chengkuo Lee, NUS, Singapore Dim-Lee Kwong, IME, A*STAR, Singapore J. Andrew Yeh, National Tsing Hua University, Taiwan Kohji Mitsubayashi, Tokyo Medical and Dental University, Japan Toshihiro Itoh, AIST, Tsukuba, Japan Yong Lian, NUS, Singapore

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Local Chair:

Chengkuo Lee Assistant Professor Department of Electrical and Computer Engineering, National University of Singapore, Singapore Chengkuo Lee received the M.S. degree in materials science and engineering from National Tsing Hua University, Hsinchu,

Taiwan, in 1991, the M.S. degree in industrial and system engineering from Rutgers University, New Brunswick, NJ, in 1993, and the Ph.D. degree in precision engineering from The University of Tokyo, Tokyo, Japan, in 1996.He worked as a Foreign Researcher in the Nanometer-scale Manufacturing Science Laboratory of the Research Center for Advanced Science and Technology, The University of Tokyo, from 1993 to 1996. He had also worked in the Mechanical Engineering Laboratory, Advanced Industrial Science and Technology (AIST), Ministry of International Trade and Industry (MITI),Tsukuba, Japan, as a Japan Science and Technology Agency (JST) Research Fellow, in 1996. Thereafter, he became a Senior Research Staff Member of the Microsystems Laboratory, Industrial Technology Research Institute, Hsinchu. In September 1997, he joined Metrodyne Microsystem Corporation, Hsinchu, and established the MEMS device division and the first micromachining laboratory for commercial purposes in Taiwan. He was the Manager of the MEMS device division between 1997 and 2000. He was an Adjunct Assistant Professor in the Electrophysics Department of National Chiao Tung University, Hsinchu, in 1998, and an Adjunct Assistant Professor in the Institute of Precision Engineering of National Chung Hsing University, Taichung, Taiwan, from 2001to 2005. In August 2001, he cofounded Asia Pacific Microsystems, Inc., where he first became Vice President of R&D before becoming Vice President of the optical communication business unit and Special Assistant to the Chief Executive Officer in charge of international business and technical marketing for the MEMS foundry service. From 2006 to 2009, he was a Senior Member of the Technical Staff at the Institute of Microelectronics, Agency for Science, Technology and Research, Singapore. He has been an Assistant Professor in the Department of Electrical and Computer Engineering, National University of Singapore, Singapore, since December 2005. He is the coauthor of Advanced MEMS Packaging (McGraw-Hill, 2010). He has contributed to more than 160 international conference papers and extended abstracts and 110 peer-reviewed international journal articles in the fields of sensors, actuators, energy harvesting, micro/nanoelectromechanical systems, nanophotonics, and nanotechnology. He is also the holder of nine U.S. patents.

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Technical Program Committee Members: (In alphabet sequence)

Adekunle Adeyeye, National University of Singapore, Singapore

Chee Kong Chui, National University of Singapore, Singapore

Chengkuo Lee, National University of Singapore, Singapore

Chia-Hung Chen, National University of Singapore, Singapore

Da-Jeng Yao, National Tsing Hua University, Taiwan

Darrin J. Young, University of Utah, USA

Dzung Viet Dao, Griffith University, Australia

Dim-Lee Kwong, IME, A*STAR, Singapore

Giorgia Pastorin, National University of Singapore, Singapore

Guanya Zhuo, National University of Singapore, Singapore

In-Hong Yang, Johns Hopkins University, USA

J. Andrew Yeh, National Tsing Hua University, Taiwan

Jin Xie, Zhejiang University, China

John Wei Mong Tsang, IME, A*STAR, Singapore

Jun Ohta, Nara Institute of Science & Technology, Japan

Kohji Mitsubayashi, Tokyo Medical and Dental University, Japan

Minkyu Je, IME, A*STAR, Singapore

Shih-Cheng Yen, SiNAPSE, NUS, Singapore

Toshihiro Itoh, AIST, Tsukuba, Japan

Wibool Piyawattanametha, Chulalongkorn University, Thailand

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Bio4Apps 2012 Information Details of Bio4Apps are available at: http://www.ece.nus.edu.sg/stfpage/elelc/Conference_Bio4Apps2012.html When and Where

The conference will be held on Nov. 19th (Mon), 2012. The venue will be the Auditorium Room, Centre for Life Science (CeLS), National University of Singapore (NUS).

Registration The registration fees for the Bio4Apps 2012 are as follows (in SGD):

Early Bird Registration by Fund Transfer

On or Before 8-Nov-2012

On-Site Registration by Cash After

8-Nov-2012

Regular & Two Days Pass 150 180

One Day Pass 100 130

For all the presenters (including oral and poster), you need to pay the regular registration fee. For other attendee, you can pay the registration fee under the scheme of either two days pass or one day pass. Conference registration package includes access to all conference sessions, tea breaks, refreshment, and an electronic copy of the Proceedings. For fund transfer and TT transfer, please refer: http://www.ece.nus.edu.sg/stfpage/elelc/Bio4Apps/Bio4Apps2012_Registration_Information.pdf

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Bio4Apps 2012 Conference Agenda – Day 1

Auditorium Room, Centre for Life Science (CeLS), NUS

JSPS Sponsored Workshop – Registration is required; Free of Charge

08:45 to 10:45

Session Chair: Prof. Shih-Cheng Yen, Department of Electrical and Computer Engineering, National University of Singapore, Singapore Opening Speech: Toward Application of Engineering to Medicine, and Food Manufacturing Prof. Renshi Sawada Kyushu University, Japan Invited Talk 1: Introduction of MEMS activities at AIST - MEMS for Green and Life Innovation Prof./Dr. Ryutaro Maeda Advanced Institute of Science and Technology (AIST), Tsukuba, Japan Talk 2: Research on a Biological Condition Analysis Based on The MEMS Blood Flow Signal Terukazu Akiyama, and Renshi Sawada Kyushu University, Japan Talk 3: Characteristics and Applications of Microsensor Measuring Linear Movement and Inclination Around Two Axes Toshihiro Takeshita1, Takuma Iwasaki2, Hideyuki Ando3, and Renshi Sawada1

1Graduate School of Systems Life Science, Kyushu University, Japan 2Department of Mechanical and Aerospace Engineering, Kyushu University 3Fuzzy Logic Systems Institute, Japan Talk 4: Skin Blood Flow During Running in Different Running Speed Wataru Iwasaki1, Masaki Nakamura1, Takeshi Gotanda1, Eiji Higurashi2 and Renshi Sawada1

1Kyushu University, Japan; 2The University of Tokyo, Japan Invited Talk 5: Low-temperature Bonding Technology for Optical Microsystems ApplicationsProf. Eiji Higurashi, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Japan Talk 6:

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Low-temperature Bonding of Laser diode Chips Using Atmospheric-pressure Plasma activation and Its Application to Micro Laser Doppler Velocimeter Michitaka Yamamoto1, Takeshi Sato1, Eiji Higurashi2, Tadatomo Suga1, and Renshi Sawada3

1School of Engineering, The University of Tokyo 2Research Center for Advanced Science and Technology, The University of Tokyo 3Department of Intelligent Machinery and Systems, Kyushu University Invited Talk 7: Chemical Reaction in Microspace: Control of Chemical Reactivity by Microfluidics Kenichi Yamashita Advanced Institute of Science and Technology (AIST), Japan

10:45 to 11:00 Break

11:00 to 13:00

Session Chair: Prof. Hongliang Ren, Department of Bioengineering, National University of Singapore, Singapore Invited Talk 8: Interaction Between Physiological Environment and Surface of Joint Prothesis – Effect on Friction and Wear Yoshinori Sawae1,2, Kazuhiro Nakashima1,2, Seido Yarimitsu2 and Teruo Murakami2 1Department of Mechanical Engineering, Kyushu University, Japan 2Research Center for Advanced Biomechanics, Kyushu University, Japan Invited Talk 9: Microscopic Structure Formation in Regenerated Cartilage Tissue Cultured Under Traction Loading Keisuke Fukuda1 and Yoshinori Sawae1,2 1Graduate school of System Life Science, Kyushu university, Fukuoka, Japan 1,2Department of Mechanical Engineering, Kyushu University, Japan Invited Talk 10: Impulse-driven capsule for medical treatments Prof. Takahiro Ito Kyushu Institute of Technology, Japan Talk 11: Capsule Robot with Flexible Micro Arm for Intestinal Surgery Phunopas Amornphun and Takahiro Ito Kyushu Institute of Technology, Japan Invited Talk 12: Development of Ambient MEMS Devices ~ Networked MEMS and Large Area MEMS Dr. Toshihiro Itoh Advanced Institute of Science and Technology, Tsukuba, Japan Talk 13:

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Development of a Wearable Body Temperature Sensor for an Early Diagnosis System of Pneumonia in Cows Hirofumi Nogami, Hironao Okada, Toru Miyamoto, Ryutaro Maeda, and Toshihiro Itoh, Advanced Institute of Science and Technology (AIST), Tsukuba, Japan Invited Talk 14: Introduction of A MEMS Sensor for Healthcare Application Noritomo Hirayama Fuji Electric Co., Japan Invited Talk 15: Application of ICT to Agriculture: Internet Control of Cattle Grazing in Mountain and Foothill Areas of Japan Takafumi Gotoh1, Tetsuji Etoh1, Yuji Shiotsuka1, Ryosuke Fujimura1, Osamu Hirano2, Makoto Maeda2, Hiroyuki Terauchi3, Hideyuki Otsuka4, Yuji Maeda5, Takeshi Nishidoi6, Kaoru Yoko-o6, Kazuhiro Suzuki6, Shinji Sawane6, Akira Muranishi6 1Kuju Agricultural Research Center, Faculty of Agriculture, Kyushu University, Kuju, Japan 2Intellectual Property Management Center, project Support Department, Kyushu University, Fukuoka, Japan 3Panasonic Communications Co., Ltd., Fukuoka, Japan 4MSK Agricultural Machine Co. Ltd., Kumamoto , Japan 5NTT departments III, (R&D Strategy Department), Tokyo, Japan 6Network Innovation Center, Fujitsu Co., Ltd., Japan

NPoster Paper 1 : Human Position Sensing with Meter-Scale Fabric Touch Sensors Hiroko Tanaka1, Seiichi Takamatsu1,2, Takahiro Imai1, Takahiro Yamashita1, and Toshihiro Itoh1,2 1Macro BEANS Center, BEANS Laboratory, Japan 2National Institute of Industrial Science and Technology, Japan

NPoster Paper 2 : Heterogeneously Integrated Bio MEMS Devices in the FIRST Project “Integrated Microsystem” Yuri Kitajima, Toshihiro Kamei, and Ryutaro Maeda, National Institute of Industrial Science and Technology, Japan

13:00 End of Workshop

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Bio4Apps Afternoon Session - Monday, November 19, 2012 Registration fee is required

12:00 ~ Registration for Bio4Apps 2012

13:15 to 13:45

Keynote I: Novel Bio-Devices for Medical and Healthcare Applications Prof. Kohji Mitsubayashi Tokyo Medical and Dental University, Japan

13:45 to 15:15

Session Chair: Prof. Darrin J. Young, Electrical and Computer Engineering Department, Bioengineering Department, University of Utah, USA Invited talk 1: Electrostatic and Electromagnetic Energy Harvester for Human Monitoring System Prof. Takayuki Fujita University of Hyogo, Japan Invited talk 2: CMOS MEMS-based Thermoelectric Power Generators Prof. Jin Xie Zhejiang University, China Invited talk 3: Solution Processable ZnO Nanostructured Materials Tailored for Sensor and Dye Sensitized Solar Cell Applications Prof. Ghim Wei Ho Department of Electrical and Computer Engineering, National University of Singapore, Singapore

Invited talk 4: Efficient Inductive Power Transfer for Biomedical Applications Prof. Yong Xin Guo Department of Electrical and Computer Engineering, National University of Singapore, Singapore

Invited talk 5: Vibration-based MEMS Energy Harvesting Systems for Wireless Biomedical Sensors Dr. Huicong Liu Department of Electrical and Computer Engineering, National University of Singapore, Singapore Invited talk 6 : MEMS Multi-Electrode Array for Neural Signal Measurement Prof. Da-Jeng Yao National Tsing Hua University, Taiwan

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15:15 to 15:45 Tea Break

15:45 to 16:15

Keynote II: Self-powered wireless biomedical sensors: Challenges and Future Prof. Yong Lian Department of Electrical and Computer Engineering, National University of Singapore, Singapore

16:15 to 17:15

Competition Session for Best Student Paper Award Session Chair: Prof. Chia-Hung Chen Department of Bioengineering, National University of Singapore, Singapore Oral Presentation 1: An 8-bit 128MSps Pipelined ADC Design for Ultrasound Needle Application Xiwei Huang1,2, Jia-Hao Cheong1, Hao Yu2 and Minkyu Je1

1Institute of Microelectronics, A*STAR, Singapore 2School of Electrical and Electronic Eng., Nanyang Technological University, Singapore Oral Presentation 2: Fiber-optic Fluoroimmunoassay System for On-site Monitoring of House Dust Mite Allergen Kumiko Miyajima1,2, Keiko Tamari3, Elise Kiyomiya3, Takahiro Arakawa2, Hiroyuki Kudo1,2, Kiyoko Shiba3 and Kohji Mitsubayashi1,2 1 Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan 2 Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Japan 3 Faculty of Health Science Technology, Bunkyo Gakuin University, Japan Oral Presentation 3: Insect Batteries Using Insect Hemolymph for Insect Robots Kan Shoji1, Yoshitake Akiyama2, Masato Suzuki1, Nobuhumi Nakamura1, Hiroyuki Ohno1, and Keisuke Morishima2

1 Tokyo University of Agriculture and Technology, Japan; 2 Osaka University, Japan Oral Presentation 4: Differentially-fed dual-band implantable antenna for biomedical applications Zhu Duan1,2, Yong-Xin Guo1, Rui-Feng Xue2, Minkyu Je2,1, and Dim-Lee Kwong2,1

1Department of Electrical and Computer Engineering, National University of Singapore, Singapore

2Institute of Microelectronics, A*STAR, Singapore

17:15 to 18:30 Refreshment & Poster SessionCeLS, NUS

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List of Poster Papers:

No.1. Lensless digital fluorescent detector using CMOS image sensor Hironari Takehara1, Daisuke Okabayashi1, Toshihiko Noda1, Kiyotaka Sasagawa1,Takashi Tokuda1, Soo Hyeon Kim2, Ryota Iino2, Hiroyuki Noji2 and Jun Ohta 1Nara Institute of Science and Technology, Japan 2 The University of Tokyo, Japan No.2. Study of a Controlling of pH Sensitivity Using Hydrogen Annealing for a Long Term pH Measurement M.Futagawa, M.Takahashi, K.Kamodo, M.Ishida, and K.Sawada Toyohashi University of Technology, Japan No.3. Reduction of Sensitivity Variation in a Filter-Less Fluorescence Detector for Biomedical Applications

H.Nakazawa, K.Yamasaki, N.Misawa, M.Ishida, and K.Sawada Toyohashi University of Technology, Japan No.4. Computational Analysis of Transient Particle with Applications to High-throughput Coulter Counter Designs Jinhong Guo1,2, Tze Sian Pui2, Abdur Rub Abdur Rahman2, and Yuejun Kang1 1School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 2Institute of Microelectronics (IME), A*STAR, Singapore No.5. Enhancement of Nanoelectronic Sensor Performance with Microfluidic Device Kyungsup Han1,2, Yong-Jin Yoon2, Jack Sheng Kee1, Mi Kyoung Park1 1Institute of Microelectronics, A-STAR, Singapore 117685 2School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798 No.6. Investigating the Mechanical Interaction between Neural Electrode and Brain Tissue Nader Hamzavi1,2, W.M. Tsang2, Victor P.W. Shim1 1Department of Mechanical Engineering, National University of Singapore 2Institute of Microelectronics, A*STAR, Singapore 117685 No.7. Development of A Ring-shaped Tri-axial tactile Sensor for Minimally Invasive Surgery Applications Beibei Han1, 2, Yong-Jin Yoon2, Muhammad Hamidullah1, Angel Tsu-Hui Lin1, and Woo-Tae Park3 1Institute of Microelectronics, A*STAR, Singapore 117685 2School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798 3Department of Mechanical and Automotive Engineering, Seoul National University of Science and Technology, Korea

No.8. Triple-Band Implantable Antenna with Open-End Slots in Ground Li-Jie Xu1, 2, Yong-Xin Guo1 and Wen Wu2 1Department of Electrical and Computer Engineering, National University of Singapore, Singapore 2Nanjing University of Science and Technology, Nanjing 210094, China

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No.9. Compact Dual-Band Antenna for Implantable Devices Changrong Liu1, 2, Yong-Xin Guo1, and Shaoqiu Xiao2 1 Department of Electrical and Computer Engineering, National University of Singapore, Singapore 2.University of Electronic Science and Technology, Chengdu, China No.10. MEMS based Optical Coherence Tomography Probe for Bioimaging Xiaojing Mu1,2, Hongbin Yu2, Hanhua Feng3, and Julius Ming-Lin Tsai2 1 Department of Mechanical Engineering, National University of Singapore, Singapore 2 Institute of Microelectronics, A*STAR, Singapore 117685 3 Temasek Engineering School, Temasek Polytechnic, Singapore No.11. Silicon Nanowires (SiNWs) Based NEMS Piezoresistive Mechanical Sensors

Songsong Zhang1, Liang Lou2, Woo-Tae Park3, Li Shiah Lim2, Wei Mong Tsang 2, Minkyu Je2 , and Chengkuo Lee1 1Department of Electrical and Computer Engineering, National University of Singapore, Singapore

2Institute of Microelectronics (IME), A*STAR, Singapore 3Department of Mechanical and Automotive Engineering, Seoul National University of Science and Technology, Seoul, Korea No. 12 Low-frequency Vibration-based Energy Harvester Using a Piezoelectric Composite Beam Lokesh Dhakar1, 2, Huicong Liu2, F. E. H. Tay1, 3 and Chengkuo Lee2 1NUS Graduate School for Integrative Sciences and Engineering, Singapore 2Department of Electrical and Computer Engineering, National University of Singapore 3Department of Mechanical Engineering, National University of Singapore No. 13 Development of Polymer-based Electrode Probes for Neural Interfacing Zhuolin Xiang1,2, Hao Wang1,2, Songsong Zhang1, Minkyu Je3, Wei Mong Tsang3, Yong-Ping Xu1, Shih-Cheng Yen1,2, Nitish V. Thakor2, Chengkuo Lee1,2* 1Department of Electrical & Computer Engineering, National University of Singapore, Singapore 2Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, Singapore 3Institute of Microelectronics (IME), A*STAR, Singapore No. 14 Development of SU-8 Microneedles Integrated With Dissolvable Tips for Transdermal Drug Delivery Zhuolin Xiang1, Hao Wang1, Chengkuo Lee1, Aakansha Pant2, Pastorin, Giorgia2

1Department of Electrical & Computer Eng., National University of Singapore, Singapore 2Department of Pharmacy, National University of Singapore, Singapore No. 15 Development of Patterned Vertically Grown Carbon Nanotubes Filters for Mass Transportation Wang Hao1, Zhuolin Xiang1,2, Chih-Fan Hu3, Chengkuo Lee1, Aakansha Pant2, Weileun Fang3, Giorgia Pastorin2

1Department of Electrical & Computer Eng., National University of Singapore, Singapore 2Department of Pharmacy, National University of Singapore, Singapore 3Department of Power Mechanical Engineering, National Tsing Hua University, Taiwan

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Bio4Apps Conference Agenda – Day 2

Bio4Apps Morning Session - Tuesday, November 20, 2012 Registration fee is required

08:00 ~ Registration for Bio4Apps 2012

08:30 to 10:00

General Session 1 – BioElectronics, BioSensors & Applications Track Session Chair: Prof. Yong Lian Department of Electrical & Computer Engineering, National University of Singapore, Singapore Keynote III: CMOS Imaging Devices for Biomedical Applications Prof. Jun Ohta Nara Institute of Science & Technology, Japan Oral Presentation 5: CMOS-Based Electrical Stimulation Circuit System for Biomedical Applications Lei Yao1, Xu Liu2, Peng Li1, Yong Ping Xu2 and Minkyu Je1

1Institute of Microelectronics, A*STAR, Singapore 2 Department of Electrical and Computer Engineering, National University of Singapore, Singapore Oral Presentation 6: A Miniaturized Tactile Sensor ASIC for a Sensorized Guide Wire in Minimally Invasive Surgical Operations Simon Sheung Yan Ng1, Chee Keong Ho1 and Minkyu Je1 1Institute of Microelectronics, A*STAR, Singapore Oral Presentation 7: Design of Inductive Coupling in Wireless Power Transfer for Neurodevices Rui-Feng Xue1, Zhu Duan2, and Minkyu Je1 1Institute of Microelectronics, A*STAR, Singapore 2 Department of Electrical and Computer Engineering, National University of Singapore, Singapore Oral Presentation 8: A Smart Electrode Array Devices with CMOS Microchip for Neural Interface Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, and Jun Ohta Nara Institute of Science and Technology, Japan

10:00 to 10:30 Tea Break

10:30 to 12:00

General Session 2– BioMedical Devices & Applications Track Session Chair: Prof. Dzung Viet Dao School of Engineering, Griffith University

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Keynote IV: Challenges and Opportunities of Microelectronics in Emerging Medical Devices Dr. Minkyu Je Institute of Microelectronics (IME), A*STAR, Singapore Invited talk 7 : Through the Clinician's Mind: Clinical-Engineering Integration Requires a Critical Rethink of Fundamentals Dr. Yee Sien Ng Department of Rehabilitation Medicine, Singapore General Hospital, Singapore Invited talk 8 : A Shared-Control Microrobotic System for Microsurgeries with Intelligent Control Prof. Chee Kong Chui, Department of Mechanical Engineering, National University of Singapore, Singapore Invited talk 9 : Surgical Instrument Tracking for Navigating Minimally Invasive Surgery Prof. Hongliang Ren, Department of Bioengineering, National University of Singapore, Singapore Invited talk 10 : Biomedical Implant System Design Enabled by MEMS and CMOS IC Prof. Darrin J. Young, Electrical and Computer Engineering Department, Bioengineering Department, University of Utah, USA

12:00 to 13:30 Lunch Break

Bio4Apps Afternoon Session - Tuesday, November 20, 2012 Registration fee is required

13:30 to 15:00

General Session 3 – BioMEMS/NEMS & Applications Track Session Chair: Prof. Guangya Zhou Department of Mechanical Engineering, National University of Singapore, Singapore Keynote V : Construction, Functionality, and Emergence of Cellular Build Up Wet Robotics Prof. Keisuke Morishima Osaka University, Japan Invited talk 11 : Manipulating Cell Behaviors via Functionalized Silicon Biochips Prof. J. Andrew Yeh National Tsing Hua University, Taiwan

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Invited talk 12 : Electrical Stimulation in Neuo-Chips In-Hong Yang1,2 1Johns Hopkins University, USA 2SiNAPSE, National University of Singapore, Singapore

Invited talk 13 : Strain Sensing Effects in Silicon Nanostructures Dzung Viet Dao1, Tung Thanh Bui2, and Susumu Sugiyama3 1School of Engineering, Griffith University, Southport, QLD 4222, Australia 2Advanced Institute of Science and Technology (AIST), Tsukuba, Japan 3Ritsumeikan University, Kusatsu, Shiga, 525-8577 Japan Invited talk 14 : Droplet Microfluidics for High Throughput Diagnosis Prof. Chia-Hung Chen Department of Bioengineering, National University of Singapore, Singapore

15:00 to 15:30 Tea Break

15:30 to 17:45

General Session 4 – Open Topics Session Chair: Prof. Chee Kong Chui Department of Mechanical Engineering, National University of Singapore, Singapore Invited talk 15 : MEMS Scanners for Circumferential Scanning Endoscopic Probes Prof. Guangya Zhou Department of Mechanical Engineering, National University of Singapore, Singapore Invited talk 16 : Advance in Light Microendoscopy Prof. Wibool Piyawattanametha1,2 1National Electronics and Computer Technology Center (NECTEC) 2Faculty of Medicine, Chulalongkorn University Oral Presentation 9 : Bionic Neural Link for Peripheral Nerve Prothesis Kian Ann Ng1, Xu Liu1, Jianming Zhao1, Li Xuchuan1, Shih-Cheng Yen1, Yong Ping Xu1, Ter Chyan Tan2, and Minkyu Je3 1Dept of Electrical and Computer Engineering, National University of Singapore, Singapore 2Dept of Hand & Reconstructive Microsurgery, National University Hospital, Singapore 3Institute of Microelectronics, A*STAR, Singapore Oral Presentation 10 : IMMU-based Gait Phase Detection using Hidden Markov Model Xiaoli Meng and Haoyong Yu, SiNAPSE and Department of Bioengineering, National University of Singapore,

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Singapore Oral Presentation 11 : Optimal thickness Ratio Study for AlN CMUT – A Simulation Study M. J. Wang1,2, A. B. Randles2, J. M. Tsai2, Y. F. Zhou1 1School of Electrical and Electronics Engineering, Nanyang Technological University, Singapore 2Institute of Microelectronics, A*STAR, Singapore Oral Presentation 12 : Accurately Charge Balanced Neuro-Stimulator with Wireless Power Delivery System Sudip Nag1,2, Nitish Thakor1,3 and Dinesh Sharma2 1Singapore Institute for Neurotechnology (SiNAPSE), National University of Singapore, Singapore 2Indian Institute of Technology Bombay; 3Johns Hopkins University Oral Presentation 13 : A Programmable Gain Amplifier for Monolithically Integrated MEMS Pressure Sensor IC Arup K. George1, 2, Wai Pan Chan1, Gao Yuan1, Zhi Hui Kong2, and Minkyu Je1 1Institute of Microelectronics, A*STAR, Singapore 2School of Electrical and Electronics Engineering, Nanyang Technological University, Singapore Oral Presentation 14: Wireless Power Transfer for Biomedical Implants Rangarajan Jegadeesan, and Yong-Xin Guo Department of Electrical and Computer Engineering, National University of Singapore, Singapore Oral Presentation 15: Patient Specific Control of Insulin Delivery for an Artificial Pancreas Yvonne Ho, and Chee-Kong Chui Department of Mechanical Engineering, National University of Singapore, Singapore

17:45 to 19:00 Closing Ceremony & Refreshment

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JSPS Sponsored Workshop

Abstracts and Biographies of Speakers

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Opening Speech:

Toward Application of Engineering to Medicine, and Food

Manufacturing Speaker:

Prof. Renshi Sawada Kyushu University, Japan

Abstract This project has two targets:

1) Development of all-around MEMS blood flow sensor (BFS) 2) formation of Asian bio-industrial infrastructure centered at Singapore and

Japan. By combining optical MEMS and ultrasonic MEMS, a novel integrated micro BFS will be developed with capability of measuring blood flow in wide range of skin depth. The ultrasonic-micro BFS deploys piezoelectric suspended membrane and photonic-crystals-based acoustic lens to generate focused ultrasonic wave propagating to much deeper region. Meanwhile, this micro BFS can also detect the contact pressure in order to make sure the tight contact between skin and micro BFS in vitro animal testing and can make the livestock insensible to the existence of the sensor and reduce the mental stress in mounting. It is expected that the world's population is growing rapidly, and only senior citizens (elderly people over the age of 65), have increased significantly in Japan. We have to accelerate the development of medical devices, healthcare equipment, and high-quality agricultural and livestock products, and develop into global market for them. This project is expected to contribute to the foundation of industrial base for developing into global market by using the bio-electronic devices.

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Renshi Sawada Professor Life Science Institute Department of Mechanical Engineering, Kyushu University, Japan

Biography Renshi Sawada received the B.E., M.E., and Ph.D. degrees from Kyushu University, Fukuoka, Japan, in 1976, 1978, and 1995, respectively. In 1978, he joined the Electrical Communication Laboratories, Nippon Telegraph and Telephone, Tokyo, Japan, where he was engaged in the research on the polishing of Si substrates, gettering of Si crystalline defects, fabrication of dielectrically isolated Si substrates (silicon on insulator substrate process), and optical microelectromechanical systems, such as micromirror array, integrated optical displacement sensors, integrated optical blood flow sensor, integrated scanning microscope, and sensors attachable to animals and humans for network. Since January 2004, he has been at Kyushu University, Fukuoka, Japan. He is an Editor of the Journal of Micromechanics and Microengineering and have served as members of the board of trustees including JIEP in 2008-2010, the Society of Instrument and Control Engineers in 2006-2007, and Kyushu branch of Japanese Society for Medical and Biological engineering since 2009. He received the Japan Society of Precision Engineering awards in 1981 and 1991, the Okawa press prize in 2001, the ninth Microoptics Conference (MOC) paper prize in 2003, and the Japan Institute of Electronic Packaging Awards in 2010, and Best Paper Award in Sensordevices of International Academy, Research, and Industry Association (IARIA). He also served as conference chair for a number of international conferences, including IEEE International Optical MEMS Conference 2000 and 2001, was also involved in Program Committees of many conferences, and is a Fellow of Institute of Physics.

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Invited Talk (1):

Introduction of MEMS activities at AIST - MEMS for Green and Life

Innovation

Ryutaro Maeda

Advanced Institute of Science and Technology (AIST), Tsukuba, Japan Biography of Presenting Author: Prof./Dr. Ryutaro Maeda

Abstract

Not available at time of press

Ryutaro Maeda received Ph.D. degree in engineering in 2006 from Toyohashi University of Technology, Aichi, Japan. He was a post doctoral researcher from 2006 to 2007, and joined the faculty of Toyohashi University of Technology from 2008 as an assistant professor. Since 2009, he has been an assistant professor in Nara Institute of Science and Technology. His current research interests focus on retinal prosthesis devices and bio-imaging with CMOS image sensors.

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Talk (2): Research on a Biological Condition Analysis Based on the MEMS Blood

Flow Signal

Terukazu Akiyama, and Renshi Sawada Kyushu University, Japan

Biography of Presenting Author: Mr. Terukazu Akiyama

Abstract

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We have developed a ultra-compact high-precision MEMS blood flow sensor with minimum component, simple structure and MEMS technology. Because high sensitive blood flow signal provide the pulse wave data simultaneously have been detected in the ECG and pulse wave meter. It is useful in respect of a multivariate analysis. In this paper, we have analyzed the blood flow signal of a cow at the time of usual and estrus.

Terukazu Akiyama was born in Japan, in September 1987. He received the B.E. degree from Nishinippon Institute of Technology, Fukuoka, Japan, in 2010 and M.E. degree from Kyushu University, Fukuoka, Japan, in 2012. He is a student of doctorate program of Kyushu University.

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Talk (3):

Characteristics and Applications of Micro Sensor Measuring Linear

Movement and Inclination around Two Axes

Toshihiro. Takeshita1, Takuma. Iwasaki2, Hideyuki. Ando3, Renshi Sawada1

1Graduate School of Systems Life Science, Kyushu University, Japan 2Department of Mechanical and Aerospace Engineering, Kyushu University, Japan

3Fuzzy Logic Systems Institute, Japan

Biography of Presenting Author: Mr. Toshihiro. Takeshita

Abstract

The authors report on the development of an optical ultra-micro-displacement sensor with a surface area of 3.0 × 3.0 mm in area and a thickness of 0.8 mm. The sensor structure is simple, consisting only of a vertical cavity surface emitting laser (VCSEL), eight two-dimensional monolithically integrated photodiodes, a frame and cover glass. This sensor can measure linear displacement with a resolution of 0.856% F.S. of 200 μm, and 1.11% F.S. of 500 μm. In addition, the device can measure inclination within resolution of 2.07% F.S. of ±1.5°. Therefore, the sensor can be utilized as a very small and highly accurate positioning mechanism and actuator, making it particularly suitable for incorporation into moving devices such as moving MEMS micro-mirrors and piezo-actuators.

Toshihiro Takeshita was born in Japan, in October 1988. He received the B.E. degree from Kyushu University, Fukuoka, Japan, in 2011 and is a student of Master’s program of Kyushu University.

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Talk (4):

Skin Blood Flow During Running in Different Running Speed

Wataru Iwasaki1, Masaki Nakamura1, Takeshi Gotanda2, Eiji Higurashi2,

and Renshi Sawada1 1Kyushu University, Japan

2The University of Tokyo, Japan

Biography of Presenting Author: Mr. Wataru Iwasaki

Abstract

Skin blood flow during running has not been studied before, because blood flow meter couldn’t measure blood flow in moving condition. We have previously developed a micro integrated laser Doppler blood flowmeter using microelectromechanical systems (MEMS) technology. The micro blood flowmeter is wearable and can measure signal stably even in a moving condition. We monitored skin blood flow during running at velocities of 6 km/h, 8 km/h, and 10 km/h, and were successful in measuring a stable signal under these conditions. We found that at the forehead the skin blood flow increases and, in contrast, at the fingertip it initially decreases during running. We also found that the level of these increases and decreases correlated with the running velocity.

Wataru Iwasaki was born in Japan, in October 1985. He received the B.E. degree and M.E. degree from Kyushu University, Fukuoka, Japan, in 2008 and 2010, respectively. He is a student of the doctorate program of Kyusyu University. He has received 2010 JIEP Academic Plaza Award in 2010 and SENSORDEVICES 2010 Best Paper Award in 2010.

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Invited Talk (5):

Low-temperature Bonding Technology for Optical Microsystems

Applications

Eiji Higurashi Research Center for Advanced Science and Technology (RCAST),The

University of Tokyo, Japan

Biography of Presenting Author: Prof. Eiji Higurashi

Abstract

Heterogeneous integration of multiple optical chips in three dimensions is an important technology for realizing highly functional, compact optoelectronic microsystems. In a conventional method using AuSn solder, however, the chips tended to be thermally damaged during the several repeated high-temperature bonding steps (300°C). In this study, three-dimensional integration of optical chips was successfully performed using Au-Au surface-activated bonding (bonding temperature: room temperature - 150°C) in ambient air. This bonding method was also suitable for chip-size packaging of microsystems. Compact and thin optical microsensors (2.8 mm × 2.8 mm × 1 mm thick) were fabricated. The feasibility of measuring velocity was demonstrated using prototype microsensors. The results show that this technique is very promising for producing various optical microsystems in use in many industrial applications.

Eiji Higurashi is an associate professor of Research Center for Advanced Science and Technology (RCAST) in the University of Tokyo. He received the M.E. degree from Tohoku University in 1991. In 1991, he joined the Applied Electronics Laboratories of Nippon Telegraph and Telephone Corporation (NTT). He received the Ph.D. degree from Tohoku University in 1999. He has been an associate professor of Department of Precision Engineering in the University of Tokyo since 2003 and an associate professor of RCAST in the University of Tokyo since 2004. He has been engaged in the research on integration and packaging of optical micro-systems. He received several awards, including the Igarashi Award in 2002, the Okawa Publications Prize in 2003, and the Ichimura Academic Award in 2008.

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Talk (6):

Low-temperature Bonding of Laser Diode Chips Using Atmospheric-

pressure Plasma Activation and Its Application to Micro Laser Doppler

Velocimeter

Michitaka Yamamoto1, Takeshi Sato1, Eiji Higurashi2, Tadatomo Suga1, and Renshi Sawada3

The University of Tokyo, Japan 2 Research Center for Advanced Science and Technology, The University of Tokyo, Japan

3 Department of Intelligent Machinery and Systems, Kyushu University Biography of Presenting Author: Mr. Michitaka Yamamoto

Abstract

We present simple Au-Au low-temperature bonding (150 ºC) method using atmospheric-presser plasma for future highly-functional optical devices. The LD chips with Au electrodes were bonded on flat topped Au stud bumps with smooth surfaces. This technology was applied to the fabrication of micro laser Doppler velocimeter (LDV). Thick Au stud bumps (15.3 μm) with smooth surfaces (Ra: 1.3 nm) were fabricated by coining the stud bumps using the flat surface (Ra: 0.2 nm) of Si chips. Whole Au-Au surface-activated bonding process including surface activation by atmospheric-pressure plasma was carried out in ambient air. Under a bonding temperature of 150 ºC and a contact load of more than 680 gf, die-shear strength exceeded the failure criteria of MIL-STD-883F, method 2019 (×2). Using this technique, compact and thin micro LDV (2.8 mm × 2.8 mm × 1 mm thick) was developed. The feasibility of measuring velocity was demonstrated for a moving Au wire (φ: 22 μm). The micro LDV detected relative speeds as low as 1 μm/s.

Michitaka Yamamoto received B.E. degree from Tokyo University, Tokyo, Japan, in 2012. He is currently working toward the M.E. degree at the Department of Precision Engineering, School of Engineering, The University of Tokyo, Tokyo, Japan. His current research interests include Au-Au Surface Activated Bonding and integration of optical components.

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Invited Talk (7):

Chemical Reaction in Microspace: Control of Chemical Reactivity

by Microfluidics

Kenichi Yamashita National Institute of Advanced Industrial Science and Technology (AIST), Japan

Biography of Presenting Author: Dr. Kenichi Yamashita

Abstract

I herein introduce the capability of the microreactor as a chemical reactor. Especially my research addressed the fundamental behavior of the solute in microchannel laminar flow, in contrast to most previous studies of the practical applications of microreactors. In contrast to a batchwise system, interaction of the solute with solvent in a microchannel laminar flow is non-isotropic, suggesting that such a behavior is characteristic of solutes in a laminar condition. Henceforth, I believe that such a fundamental study of the behavior of molecules in a microchannel laminar flow can elucidate microchannel-enhanced chemical reactions and simultaneously enable exploration of controlling chemical reactions using a microreactor. In some experiments, I chose DNA strands as the subject of our study and investigated their duplex formation and behavior in microchannels based on the fact that DNA is directly visible and that exact measurement of duplex formation of DNA can be done using physicochemical analysis. The use of DNA also enables theoretical discussions of such reactions. Based on thermodynamic analysis, the change in conformational entropy caused by microfluidic stretching and orientation of DNA strands is an important factor in the microfluidic thermal stability shift. Moreover, kinetic analysis shows that the microchannel laminar flow enables change of reaction rate by inducing a change in activation energy. It is suggested that a microfluidic system is useful for performing fast reactions by influencing the activation energy and producing an enhancement effect, even without the presence of catalysts.

Senior Research Scientist Measurement Solution Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Japan

Kenichi Yamashita received the M. E. and Ph.D. degree from Kyushu University, Fukuoka, Japan, in 2000 and 2002, respectively. Since 2002, he has worked in AIST as a research scientist.

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Invited Talk (8):

Interaction Between Physiological Environment and Surface of Joint

Prosthesis - Effects on Friction and Wear

Yoshinori Sawae1,2, Kazuhiro Nakashima1,2, Seido Yarimitsu2 and Teruo Murakami2 1Department of Mechanical Engineering, Kyushu University, Japan

2Research Center for Advanced Biomechanics, Kyushu University, Japan

Biography of Presenting Author: Prof. Yoshinori Sawae

Abstract

Total hip arthroplasty (THA) and total knee arthroplasty (TKA) are popular surgical treatments whereby the diseased hip and knee joints are replaced with joint prostheses to reconstruct joint functions. Although joint capsule and synovial membrane are resected during the operation, they are soon regenerated around implanted artificial joint and internal space of the capsule is filled with periprosthetic fluid secreted from the synovial membrane. The periprosthetic fluid contains many kinds of electrolytes, radicals, nutrients and biological macromolecules, such as proteins, lipids and hyaluronic acid. These constituents should be entrained into the contact area between articulating surfaces during joint movements and possibly have some chemical and mechanical interactions with the surface of joint prosthesis. Consequently, friction and wear characteristics of prosthetic joint in vivo are inevitably subjected to the influence of physiological environment. In this study, static and dynamic behavior of protein adsorption on the surface of prosthetic joint materials was examined in the simulated synovial joint environment by using atomic force microscopy and fluorescent microscopy. Subsequently, effects of the physiological environment on the friction and wear behavior of implanted joint prostheses were discussed.

Yoshinori Sawae received the degree of B.S. in 1991, M.S. in 1993 and Dr.Eng in 1996 in Mechanical Engineering from Kyushu University, Fukuoka, Japan. He joined Department of Mechanical Engineering, Kyushu University as a lecturer in 1996 and became a Professor of Machine Elements and Design Engineering Laboratory in 2011. Current research interests are primarily friction, wear and lubrication in artificial joints and natural synovial joints.

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Talk (9):

Microscopic Structure Formation in Regenerated Cartilage Tissue

Cultured Under Traction Loading

Keisuke Fukuda1 and Yoshinori Sawae2 1Graduate school of System Life Science, Kyushu University, Japan 2Department of Mechanical Engineering, Kyushu University, Japan

Biography of Presenting Author: Mr. Keisuke Fukuda

Abstract

In this study, chondrocytes isolated from bovine cartilage tissue were seeded in agarose gel and resultant chondrocyte-agarose constructs, a well-established experimental model to examine the effect of mechanical loadings on the chondrocyte metabolism, were cultured with a traction loading on the construct surface to examine its effect on the regeneration of the cartilaginous tissue by chondrocytes. Custom-designed mechanical loading equipment was developed to apply the traction loading on the upper surface of constructs being cultured in the CO2 incubator. After 2 to 3 weeks culture, immunofluorescent staining of keratin sulfate, a type of glycosaminoglycan (GAG) chain consisting proteoglycan molecules, and type II collagen was performed to verify the chondrocyte biosynthesis of extra cellular matrix (ECM) and characterize the structure of elaborated cartilaginous tissue by confocal laser scanning microscopy (CLSM). Viscoelastic properties of cultured construct were also evaluated by using a rotational rheometer. Results indicated that the traction loading enhance ECM biosynthesis in the surface region of constructs and collagen rich layer covered with GAG rich superficial layer was formed in the articulating surface. Storage modulus and loss tangent of the elaborated tissue were also enhanced by the traction loading.

March, 2011 Received B.S. in mechanical engineering from Kyushu University, Fukuoka, Japan.

April, 2011 Admitted to Graduate School of Systems Life Sciences, Kyushu University

March, 2013 Expected to receive M.S. in Systems Life Sciences from Kyushu University

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Invited Talk (10):

Impulse-driven Capsule for Medical Treatment

Takahiro Ito

Dept. of Computer Science and Systems, Kyushu Institute of Technology, Japan

Biography of Presenting Author: Prof. Takahiro Ito

Abstract

We have developed a traveling small capsule, which has smooth outer surface and is driven by the inertia force and friction force. It is small enough, only 7 mm in diameter and 12 mm long, it can be put in the human gullet or intestines. The capsule contains a small magnet and a coil, and electric pulse drives the magnet to move the capsule. To investigate the feasibility of our traveling capsule, we did the theoretical analysis and computer simulation using a simple model. We did the experimental investigation that our capsule can travel on a plastic plate and it can also travel on pig intestine surface. Our capsule is supposed to be useful for medical treatment such as inspection, drug delivery or operation.

Takahiro Ito received the B.E. and M.E. degree in mechanical engineering from the University of Tokyo, Japan in 1983 and 1985 respectively and the M.S. degree in computer science from the University of Illinois at Urbana-Champaign in 1992. He received Ph.D. degree from the University of Tokyo in 2002. In 1985, he joined the NTT Electrical Communication Laboratories, Tokyo, Japan. Since March 2008, he has been a professor at Kyushu Institute of Technology, Japan. He is also the general manager of the center for microelectronic systems. His research interests are micro-mechanism, sensor, and MEMS devices for medical application.

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Talk (11):

Capsule Robot with Flexible Micro Arm for Intestinal Surgery

Phunopas Amornphun, and Takahiro Ito Kyushu Institute of Technology, Japan

Biography of Presenting Author: Dr. Phunopas Amornphun

Abstract

The use of micro fiber for the transmission of the forces and the movements in robotic micro arms has been investigated from several researchers. The interest in this kind of actuation modality is based on the possibility of optimizing the position of the actuators with respect to the moving part of the robot, in the reduced weight, reliability, simplicity in the mechanic design and flexibility with many DOF. This paper proposes a novel flexible micro arm that uses BioMetal Fiber (BMF) actuator. The BMF has very high durability and exhibits stable operating characteristics. It is being thin but capable of producing a powerful force. This platform can enable new medical devices for a capsule robot and for minimally invasive surgeries. This paper presents kinematics of the flexible micro arm and bending properties. An experiment has been developed with the impulse driven capsule robot. The flexible micro arm is manually controlled using a camera guide for manipulating to desired position.

Phunopas Amornphun received the B.S. degree in Electronics Physics from Thammasat University, Thailand in 2004, M.S. degree in Robotics and Automation from King Mongkut’s University of Technology Thonburi, Thailand in 2009, and Ph.D. degree in Mechanical Information System from Kyushu Institute of Technology, Japan in 2012.

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Invited Talk (12):

Development of Ambient MEMS Devices, Networked MEMS and Large

Area MEMS

Toshihiro Itoh

Advanced Institute of Science and Technology (AIST), Tsukuba, Japan

Biography of Presenting Author: Dr. Toshihiro Itoh

Abstract

Two examples of “ambient” MEMS devices, MEMS sensors integrated with wireless communication function (wireless sensor node) and large area MEMS fabricated by continuous micro/nano-manufacturing and integration process for fibers, will be introduced. One of the important technological issues to realize maintenance-free sensor network systems is power reduction of each wireless sensor node. By developing novel ultra-low power (ULP) MEMS sensors and custom LSI with event-driven mode, we have successfully developed an ULP sensor node with the power consumption around 1 µW. As large area MEMS, fabric devices fabricated by weaving integration of micro/nano-machined fibers, such as a 1 m x 1 m touch sensor, will be presented. The fabrication process of our large area devices consists of continuously high-speed coating for functional film materials, 3-D micro/nano-machining of the films on fibers, and weaving the functional fibers into large-area integration.

Toshihiro Itoh received the BE, ME, and Ph.D. degrees in precision engineering from the University of Tokyo, Japan, in 1988, 1990 and 1994, respectively. He is currently a leader of Collaborative Research Team of Macro BEANS (Bio Electromechanical Autonomous Nano Systems), and a deputy director of Research Center for Ubiquitous MEMS and Micro Engineering (UMEMSME) in National Institute of Advanced Industrial Science and Technology (AIST), Japan. Also he has been a director of Macro BEANS Center, METI/NEDO BEANS project and a director of Tsukuba Research Center, NEDO “Green Sensor Network System Technology Development” project since 2008 and 2011, respectively. He had joined the faculty of the University of Tokyo in 1995 and was an associate professor at the Research Center for Advanced Science and Technology (RCAST) and the Department of Precision Engineering from 1999 to 2007. His research interests are in MEMS and wireless sensor nodes for sensor networks as well as large area MEMS.

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Talk (13):

Development of a Wearable Body Temperature Sensor for an Early Diagnosis System of Pneumonia

in Cows

Hirofumi Nogami, Hironao Okada, Toru Miyamoto, Ryutaro Maeda, and Toshihiro Itoh Advanced Institute of Science and Technology (AIST), Tsukuba, Japan

Biography of Presenting Author: Dr. Hirofumi Nogami

Abstract

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Calves have a high rate of attrition from pneumonia and calf scours. To decrease attrition rate, automatic monitoring system for early diagnosis has been required. We developed wearable wireless sensor nodes for the system. This sensor node is 12 millimeters in length and width, 5 millimeters thick and weighs 5 grams. It uses 300MHz transmission. The measurement items are temperature and acceleration. We attached this wireless sensor node to a calf tail close to an anus, and measured skin temperature and acceleration for two weeks. We could confirm circadian change measured by skin temperature and distinguish between a standing position and a sitting position measured by acceleration.

Hirofumi Nogami received the B.E (2005) degree in Faculty of Engineering from Kyushu University, M.E (2008) and Ph.D. (2011) degrees in graduate school of Systems Life Sciences from Kyushu University. He has worked at Advanced Institute of Science and Technology (AIST) since April, 2011. His research works are potentially in commercial development in animal health monitoring system and the wireless sensor node.

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Invited Talk (14):

Introduction of A MEMS Sensor for Healthcare Application

Noritomo Hirayama

Measurement of Instrument Development Dept. Measurement Technology Development Center,

Product Technology Laboratory, Corporate R&D Headquarters Fuji Electric Co.,Ltd, Japan

Biography of Presenting Author: Mr. Noritomo Hirayama

Abstract

In Fuji Electric, various MEMS sensors have been manufactured for industrial use. A MEMS sensor has the feature of small size, integration, and low power consumption, and can expect the low cost by mass production. With these features, we consider the vital sensing for health care application. In this paper, a micromachined gas sensor based on a catalytic thick film/SnO2 thin film bilayer and other sensors are presented.

Noritomo Hirayama received the B.E. degree in Mechanical Engineering from the Kogakuin University in 1991. In 1991, he joined the Fuji Electric Corporate Research and Development, Ltd. He works as a research engineer at Fuji Electric Co., Ltd. Currently he is a senior manager at Measurement of Instrument Development Dept., Measurement Technology Development Center in the Product Technology Laboratory, Corporate R&D Headquarters, Fuji Electric Co.,Ltd, Japan He has been engaged in the research on the optical measurement and various sensing technologies such as tunable diode laser absorption spectroscopy for gas concentration, ultrasonic Doppler Velocity profiler for Fluid flow and non-invasive biosensor. He received the prize for an excellent work in the Japan Electrical Manufactures’ Association in 2008.

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Invited Talk (15):

Application of ICT to Agriculture: Internet Control of Cattle Grazing in

Mountain and Foothill Areas of Japan

Takafumi Gotoh1, Tetsuji Etoh1, Yuji Shiotsuka1, Ryosuke Fujimura1, Osamu Hirano2,

Makoto Maeda2, Hiroyuki Terauchi3, Hideyuki Otsuka4, Yuji Maeda5, Takeshi Nishidoi6, Kaoru Yoko-o6, Kazuhiro Suzuki6, Shinji Sawane6, Akira Muranishi6

1Kuju Agricultural Research Center, Faculty of Agriculture, Kyushu University 8780201,

Kuju, Japan 2Intellectual Property Management Center, project Support Department, Kyushu

University, 8128581, Fukuoka, Japan 3Panasonic Communications Co., Ltd., 8128531, Fukuoka, Japan 4MSK Agricultural Machine Co. Ltd., 8691235, Kumamoto , Japan

5NTT departments III, (R&D Strategy Department), 1008116, Tokyo, Japan 6Network Innovation Center, Fujitsu Co., Ltd., 2118588, Japan

Biography of Presenting Author: Prof. Takaufmi Gotoh

Abstract

In recent times the Japanese government has recommended that farmers graze cattle on abandoned agricultural fields. However, it is not so easy to control and carry out daily checks on cattle grazing in mountain and foothill areas. To help resolve this burdensome farming task, we are creating an internet based ICT control system intended to provide not only feed concentrate but also to monitor cattle grazing abandoned agricultural fields in mountain and foothill areas. We will present current results regarding this system.

Takafumi Gotoh is an associate professor who belongs to graduate school of agriculture, at Kuju Agricultural Research Center, Kyushu University. He received his B.Sc, M.Sc. and Ph.D. degrees in Department of Animal Science from Kyushu University, Japan in 1988, 1990 and 1997, respectively. He is basically an animal scientist, especially he is studying cattle. His research topics are creation of beef production system, metabolic imprinting. Because he works in university farm, he has started ICT farm project. Now he is doing joint researched with ICT scientists and private companies in Japan. He was awarded by Japanese Society of Animal Science for a thesis entitled “Histochemical Properties of Skeletal Muscles in Japanese Cattle and Their Meat Production Ability” in 2001.

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JSPS Poster Paper (1):

Human Position Sensing with Meter-Scale Fabric Touch Sensors

Hiroko Tanaka1, Seiichi Takamatsu1,2, Takahiro Imai1, Takahiro Yamashita1,

and Toshihiro Itoh1,2 1 Macro BEANS Center, BEANS Laboratory, Japan

2 National Institute of Industrial Science and Technology (AIST), Japan Biography of Presenting Author: Ms. Hiroko Tanaka

Abstract

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Recently, human position sensing devices have attracted great deal of attention for the applications to elders or nursing cares. Electronic textiles that integrate sensors into fabrics are ideal because they have the advantage of instantly obtaining information from humans. Textiles can cover extremely large-area (> 1 m2) because meter-scale fabric is woven by automatic looming machines. In this paper, human position sensing device which consists of highly conductive polymer-coated fibers are reported. Meter-scale long fibers with a conductive PEDOT:PSS layer were used as an enough large electrode to detect human foot or hands. Using the 1 meter-long fibers, a touch with about 5 cm wide human hand can produce capacitance change of more than 1 pF, which is large enough to detect with the capacitance meter integrated in standard MCUs.

Hiroko Tanaka has been a researcher of Macro BEANS (Bio Electromechanical Autonomous Nano Systems) Center, BEANS Laboratory that established under NEDO/METI BEANS project, since 2007. She joined the secretary of Nanoimprint Process Solution Consortium (NIPS), Japan, from 2005 to 2006.

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JSPS Poster Paper (2):

Heterogeneously Integrated Bio MEMS Devices in the FIRST Project

“Integrated Microsystem”

Yuri Kitajima, Toshihiro Kamei, and Ryutaro Maeda National Institute of Industrial Science and Technology (AIST), Japan

Biography of Presenting Author: Ms. Yuri Kitajima

Abstract

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In the “Integrated Microsystem” project of Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST),, the AIST research team has been trying to develop MEMS integration process for prototyping for hetero integration on 8- or 12-inch Si wafers and high efficiency production. For instance, a fabrication process of heterogeneously integrated fluorescence detector for microfluidic biochemical analysis has been developed. We have proposed an annular fluorescence detector in which an optical interference filter is monolithically integrated on an a-Si:H pin photodiode. This allows laser light to pass through the detector and to irradiate a microchannel, enabling coaxial configuration of excitation source and detector. In this paper, the “Integrated Microsystem” project and examples of developed integrated MEMS devices including Bio MEMS will be introduced.

Yuri Kitajima has been a member of research team for the “Integrated Microsystem” Project of Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST) in AIST, Japan, since 2010.

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Bio4Apps 2012

Abstracts and Biographies of Speakers

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Keynote I

Novel Bio-Devices for Medical and Healthcare

Applications Keynote Speaker:

Prof. Kohji Mitsubayashi Tokyo Medical and Dental University, Japan

Abstract Rapid increasing of diabetes mellitus is now global problem and development of a safe and non-invasive and continuous method of blood sugar monitoring is strongly requested. We paid attention to the relationship between the tear glucose level and the blood sugar level. In this lecture, a soft contact lens type glucose sensor using biocompatible polymers will be introduced. The biosensor was designed for continuous glucose monitoring in tear fluids on eye site. In order to achieve flexibility and biocompatibility, the biosensor utilizes some functional polymers. Owing to the flexible laminar structure of the polymers, the sensor fits the rounded shape of human body and has good biocompatibility. The sensor measures the glucose concentration as a current change induced by enzyme reaction at the GOD immobilized polymer layer. In the MEMS fabrication process, film electrodes were formed on polymer substrate using sputtering method. The sensor also showed high flexibility and was soft and comfort to the touch. The sensor showed linearity in glucose level of 0.05 – 3.00 mmol/l with a correlation coefficient of 0.998. The calibration range includes the reported concentration of tear glucose in normal human subject. The sensor was attached on the rabbit eye as mentioned before and tear glucose level of the rabbit eye was monitored continuously. In this lecture, I will also show other unique bio-devices for the medical and healthcare applications in the near future.

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Kohji Mitsubayashi Professor Dept. of Biomedical Devices and Instrumentation, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Japan

Biography Kohji Mitsubayashi received the degree of B.E. (1983) and M.E. (1985) in Mechanical Engineering from Toyohashi University of Technology, and the Ph.D. degree in Interdisciplinary Course on Advanced Science and Technology from The University of Tokyo (1994). He worked as a company researcher at DENSO Corporation (1985-1998). He was an associate Professor in the Department of Electrical Engineering (1998-2001) and Information sciences (2001-2003) at Tokai University. Since 2003, he has been a Professor in the Department of Biomedical Devices and Instrumentation at Tokyo Medical and Dental University. His research interests includes wearable biosensors with Soft-MEMS techniques for non-invasive biochemical-monitoring, biochemical gas sensors (Bio-Sniffer) and gas visualization system for human odor and halitosis analysis, novel artificial organs (hands, pancreas) with “Organic Engine” converting from chemical to mechanical energy, etc.

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Keynote II

Self-Powered Wireless Biomedical Sensors: Challenges and Future

Keynote Speaker:

Prof. Yong Lian National University of Singapore, Singapore

Abstract Body Sensor Network (BSN) combined with wearable/ingestible/injectable/ implantable biomedical devices is envisaged to be the next wave of technology for future healthcare. BSN allows continuous or intermittent monitoring of physiological signals and is critical for the advancement of both the diagnosis as well as treatment. With the advances in nanotechnology and integrated circuit, it is possible to build miniaturized system-on-chip solutions for implantable or wearable wireless biomedical sensors. Such wireless biomedical sensors will benefit millions of patients who need constant monitoring of critical physiological signals anytime, anywhere. It also improves the quality of life for many individuals. This talk will cover research topics related to the wireless biomedical sensors, especially on the development of self-powered wireless biomedical sensors and associated low power techniques. Several design examples of ultra low power biomedical sensor are discussed to illustrate the effectiveness of new low power techniques.

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Yong Lian Provost’s Chair Professor Area Director, Integrated Circuits & Embedded Systems Department of Electrical and Computer Engineering, National University of Singapore, Singapore

Biography Yong Lian is a Provost’s Chair Professor and Area Director of Integrated Circuits and Embedded Systems in the Department of Electrical & Computer Engineering, NUS. He is the Founder of ClearBridge VitalSigns Pte Ltd, a start-up for wireless wearable biomedical devices. His research interests include low power circuit techniques, signal processing, and wireless miniaturised biomedical devices. He is the recipient of the 1996 IEEE Circuits and Systems (CAS) Society's Guillemin-Cauer Award, the 2008 Multimedia Communications Best Paper Award from the IEEE Communications, and many other awards. He is also a recipient of the 2009 and 2010 NUS Annual Teaching Excellence Awards. Dr. Lian is the Editor-in-Chief of the IEEE Transactions on Circuits and Systems II, Steering Committee Member of the IEEE Transactions on Biomedical Circuits and Systems (BioCAS), Chair of DSP Technical Committee of the IEEE CAS Society. He was the Vice President for Asia Pacific Region of the IEEE CAS Society from 2007 to 2008, Chair of the BioCAS Technical Committee of the IEEE CAS Society (2007-2009), the Distinguished Lecturer of the IEEE CAS Society (2004-2005). Dr. Lian is a Fellow of IEEE.

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Keynote III

CMOS Imaging Devices for Biomedical Applications

Keynote Speaker:

Prof. Jun Ohta Nara Institute of Science and Technology, Japan

Abstract Recent progress of implantable biomedical devices based on CMOS image sensor technologies is reviewed. First, Retinal prosthetic devices are presented. To partially restore vision for blind patient suffered from retinitis pigmentosa and age-related macular degeneration, retinal prosthetics devices are implanted in the retina and electrically stimulate retinal cells. The present status and future directions are described including our recent results to realize over 1000 stimulus points, which are required to gain clear vision. We are developing a retinal prosthesis device with large numbers of electrodes by introducing micro CMOS imaging devices with simulating functions. We have successfully demonstrated that the CMOS-based stimulator implanted in a rabbit eye can stimulate the retinal cells. Next, mountable micro imaging devices in a mouse brain are introduced. The present status are reviewed including our approach, where a micro imaging device is directly implanted into mouse deep brain with minimal invasiveness to measure neural activities through fluorescence. The device consists of a dedicated micro CMOS image sensor and LEDs to excite fluorophore on a flexible substrate. We have successfully demonstrated real-time in vivo molecular imaging inside the brain of a freely-moving mouse. Finally I address the future direction of the implantable biomedical CMOS imaging devices.

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Jun Ohta Professor Graduate School of Materials Science, Nara Institute of Science Technology, Japan

Biography

Jun Ohta received the B.E., M.E., and Dr. Eng. degrees in applied physics, all from the University of Tokyo, Japan, in 1981, 1983, and 1992, respectively. In 1983, he joined Mitsubishi Electric Corporation, Hyogo, Japan. From 1992 to 1993, he was a visiting researcher in Optoelectronics Computing Systems Center, University of Colorado at Boulder. In 1998, he joined Graduate School of Materials Science, Nara Institute of Science and Technology (NAIST), Nara, Japan as Associate Professor. He was appointed as Professor in 2004. His current research interests are vision chips, CMOS image sensors, retinal prosthesis, and biomedical-photonic LSIs. He received several awards including “The National Commendation for Invention” in 2001, “The Izuo Hayashi Award, Japanese Society of Applied Physics” in 2009, and so on. He serves as a Councilor of Japanese Society of Applied Physics, and a Chair of Information Sensing Research Committee of Institute of Image Information and Television (ITE), Japan, and an Editor of ITE Transactions on Media Technology and Applications. In 2008 to 2011, he also serves as a Far East Regional Committee and an International Technical Program Committee in Imagers, MEMS, Medical devices, and Displays of IEEE International Solid-State Circuits Conference (ISSCC). He is a member of the Japan Society of Applied Physics, IEICE Japan, ITE Japan (Fellow), IEEE, and OSA.

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Keynote IV

Challenges and Opportunities of Microelectronics in Emerging

Medical Devices Keynote Speaker:

Dr. Minkyu Je Institute of Microelectronics, A*STAR, Singapore

Abstract Many factors such as extended average life span, prevailing obesity, and globally aging population are increasing the healthcare cost dramatically (e.g. $2.3 trillion in the U.S. in 2008). Recent advances in integrated microelectonics have led to the microsystems with sensing, actuating, processing, and communicating capabilities that can supplement, improve, or even entirely replace, traditional biomedical diagnostic & therapeutic procedures. Integrated biomedical solutions based on microelectronics can offer extremely effective ways of timely diagnosis, treatment, and management of diseases at very low cost never seen before.

Medical devices are evolving in terms of their energy sources and diversifying in their physical platforms. As the energy source evolves from primary to secondary batteries, to wireless power, and further to harvested ambient energy, the available amount of energy to operate devices becomes smaller and smaller. To support this trend, the current low-power microelectronics and microsystems have to be pushed further to achieve micro/nano power consumption. Considering the physical platform of emerging medical devices, in addition to the traditional titanium can, many different platforms are making (or trying to make) an entrance to the market, and generally speaking, those new platforms tend to require extreme miniaturization towards micro/nano scale. As a result, the integrated microelectronics and microsystems have to provide solutions for new emerging physical platforms.

In this talk, it will be presented how the integrated microelectronics overcome the challenges of extreme down-scaling in power consumption and physical dimensions, to enable emerging medical devices by providing seamless sensing and actuating interfaces, high-efficiency operation with various energy sources (especially, renewable ones), high-level integration and miniaturization, embedded intelligence, and connectivity.

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Minkyu Je Senior Scientist Integrated Circuits and Systems Laboratory, Institute of Microelectronics (IME), Agency for Science, Technology and Research (A*STAR), Singapore

Biography Minkyu Je received the M.S. and Ph.D. degrees, both in electrical engineering and computer science, from Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea, in 1998 and 2003, respectively. In 2003, he joined Samsung Electronics, Giheung, Korea, as a Senior Engineer and worked on multi-mode multi-band RF transceiver SoCs for GSM/GPRS/EDGE/ WCDMA standards.

Since 2006 he has been with Institute of Microelectronics (IME), Agency for Science, Technology and Research (A*STAR), Singapore, and is currently working as a Senior Scientist and leading the Integrated Circuits and Systems Laboratory. Since he joined IME, he has led various projects developing low-power 3D accelerometer ASICs for high-end medical motion sensing applications, readout ASICs for nanowire biosensor arrays detecting DNA/RNA and protein biomarkers for point-of-care diagnostics, ultra-low-power sensor node SoCs for continuous real-time wireless health monitoring, and wireless implantable sensor ASICs for medical devices, as well as low-power radio SoCs and a MEMS interface/control SoCs for consumer electronics and industrial applications. His main research areas are low-power analog & mixed-signal circuits and systems interfacing with bio and MEMS sensors, circuit design and multi-functional system integration with novel devices and technologies, wireless telemetry circuits and systems for bio-medical applications, and heterogeneous 3D IC systems. He has more than 100 peer-reviewed international conference and journal publications in the areas of sensor interface IC, wireless IC, biomedical microsystem, 3D IC, device modeling and nanoelectronics.

He is also a Program Manager of NeuroDevices Program under A*STAR Science and Engineering Research Council (SERC) and an Adjunct Assistant Professor in the Department of Electrical and Computer Engineering at National University of Singapore (NUS). He currently serves on the Technical Program Committee of the IEEE International Solid-State Circuits Conference (ISSCC).

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Keynote V

Construction, Functionality, and Emergence of

Cellular Build Up Wet Robotics Keynote Speaker:

Prof. Keisuke Morishima Osaka University, Japan

Abstract There have been so far many studies on downsizing and integration of “man-made machines”; not only semiconductor devices but also mechanical systems and chemical systems, such as micro electro mechanical systems (MEMS) and micro total analytical systems (µTAS). Those systems and devices are driven by external energy power source. Most of their fabrication process is based on “top-down approach.” However, this top-down approach generally need a large-scale external system and have many issues regarding energy conversion efficiency, energy supply system, and sensitivity. We have demonstrated an environmentally robust hybrid (biotic–abiotic) robotic system that uses living components, called “Cellular Build Up Wet Nano Robotics”. Our group has already presented a bioactuator using rat heart muscle cells, but it is difficult to keep rat heart muscle cells contracting spontaneously without maintaining the culture conditions carefully. By contrast, insect cells are much robust over a range of culture conditions (temperature, osmotic pressure and pH) compared to mammalian cells. Therefore, insect cells are more practical use of a hybrid wet robotic system, and they can be driven without precise environmental control. From this point of view, to utilize robust biological components as a functional systems and self assembly process and their emergent functionality, and to build up such a soft and wet machines will lead us an innovative fundamental change and produce a new principle and design to future man-made systems. We demonstrate the example of a micro bioactuator and mechanical systems driven by biochemical energy. This novel muscle-powered bioactuator successfully show autonomous beating at room temperature for a long time without maintenance. Experimental results suggest the possibility of constructing an environmentally robust hybrid wet robotic system with living components and open up a new science and technology, biorobotic approach, medical, environmental monitoring, agriculture and industrial application.

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Keisuke Morishima Professor Department of Mechanical Engineering, Osaka University, Japan

Biography Dr. Keisuke Morishima is a Professor, Department of Mechanical Engineering, Osaka University, JAPAN; he graduated from Nagoya University where he received his PhD in Engineering from Nagoya University, in 1998. In 1997, he was JSPS Postdoctoral Research Fellow. From 1998 to 2001, he was a Postdoctoral Research Associate in Prof. Richard N. Zare Lab at Department of Chemistry, Stanford University, USA. He joined Kanagawa Academy of Science and Technology as a Research Scientist in 2001. Meanwhile, he was a Research Fellow at the Research Association of Micro Chemical Process Technology and a Visiting Research Fellow. In 2004, he was a Visiting Research Fellow at Lund Institute of Technology, Sweden. In 2005, he joined Department of Mechanical Systems Engineering, Tokyo University of Agriculture and Technology as an Associate Professor. In 2007, he joined Department of Bio-Mechanics and Intelligent Systems, Tokyo University of Agriculture and Technology, Japan. In 2011, he moved to Department of Mechanical Engineering, Osaka University as a Professor. He is mainly engaging in the research fields of Micro-Nano Robotics and its application to the micro-nanomanipulation, bio automation, BioMEMS, MicroTAS, microactuators, medical applications, living machine, soft & wet nano robotics, regenerative medicine. In recent years, he received 2009 Best Paper Award, The Robotics Society of Japan, 2009 The Young Scientists’ Prize, The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology, 2006 Young Scientist Award, Ando Foundation. He also served as Program Committees of NEMS, MicroTAS, Nanomedicine conference, and technical editorial board of IEEE Nanotechnology Magazine.

References [1] “Cardiomyocyte-Driven Gel Network for Bio-Robotics”,DOI: 10.1007/s10544-012-9714-z, Biomedical

Microdevices, (2012) [2] “Rapidly-moving insect muscle-powered microrobot and its chemical acceleration”,DOI:

10.1007/s10544-012-9700-5,Biomedical Microdevices, (2012) [3] “Insect biofuel cells using trehalose included in insect hemolymph leading to an insect-mountable

biofuel cell”, DOI: 10.1007/s10544-012-9706-z, Biomedical Microdevices, (2012). [4] “Cell patterning through inkjet printing of one cell per droplet”, doi:10.1007/s12213-012-0047-z,

Biofabrication, (2012) [5] “Room temperature operable autonomously moving bio-microrobot powered by insect dorsal vessel

tissue”, Y. Akiyama, T. Hoshino, K. Iwabuchi, and K. Morishima, PLoS ONE, (2012) [6] “Long-term and room temperature operable bio-actuator powered by insect dorsal vessel tissue”, Y.

Akiyama, K. Iwabuchi, Y. Furukawa, K. Morishima, Lab on a Chip, vol. 9, pp. 140-144, (2009) [7] “Culture of Insect Cells Contracting Spontaneously toward an Environmentally Robust Hybrid Robotic

System”, Y. Akiyama, K. Iwabuchi, Y. Furukawa, and K. Morishima, Journal of Biotechnology‚ Vol. 133, p.261–266, (2008)

[8] “An actuated pump on-chip powered by cultured cardiomyocytes”, Y. Tanaka, K.Morishima, T. Shimizu, A. Kikuchi, M. Yamato, T. Okano, and T. Kitamori, Lab on a Chip, Vol.6(3), p. 362 - 368, (2006)

[9] “Demonstration of a bio-microactuator powered by cultured cardiomyocytes coupled to hydrogel micropillars”, K. Morishima, Y. Tanaka, M. Ebara, T. Shimizu, A. Kikuchi, M. Yamato, T. Okano and T. Kitamori, Sensors & Actuators: B. Chemical, Vol. 119, p.345–350, (2006)

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Invited Talk (1):

Electrostatic and Electromagnetic Energy Harvester for Human

Monitoring System

Takayuki Fujita University of Hyogo, Japan

Biography of Presenting Author: Prof. Takayuki Fujita

Abstract

Our project aims to realize an ultra-small wearable sensor network that monitors the human activity and human condition, which improves the quality and safeness of the human daily life. The system is constituted by the fully batch fabricated MEMS (Micro electromechanical systems) sensors, MCU (Micro control unit), ICs (Integrated circuits), RF module and also energy harvester for power supply. The energy harvester is one of the small power generators that obtain the electrical energy from the ambient environment. This autonomous power supply provides the continuous monitoring system for long periods. This study reports a fabrication of the vibratory type energy harvester by using electrostatic and electromagnetic mechanism and also shows its performance on the human vibration by using the data logger.

Takayuki Fujita is an associate professor of the Department of Electrical Engineering and Computer Sciences in the University of Hyogo. He received B. E., M. E., and Ph. D. degrees from the Himeji Institute of Technology, Japan, in 1995, 1997, and 2000, respectively. Since 2001, he has been a Research Associate at the Himeji Institute of Technology. Since 2008, he has been the micro-power group leader of the ERATO Maenaka Human-Sensing Fusion Project supported by the Japan Science and Technology Agency. His research topics are MEMS sensors and its system, and vibratory type MEMS energy harvester.

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Invited Talk (2):

CMOS MEMS-based Thermoelectric Power Generators

Jin Xie

Zhejiang University, China Biography of Presenting Author: Prof. Jin Xie

Abstract

This paper presents CMOS microelectromechanical systems- based thermoelectric power generators (TPGs) to convert waste heat into a few microwatts of electrical power. Phosphorus and boron heavily doped polysilicon thin films are patterned and electrically connected to consist thermopiles in the TPGs. To optimize heat flux, the thermal legs are embedded between the top and bottom vacuum cavities, which are sealed on the wafer level at low temperature. A heat-sink layer is coated on the cold side of the device to effectively disperse heat from the cold side of the device to ambient air. The peripheral cavity is designed to isolate heat from the surrounding silicon substrate. Both simulation and experiments are implemented to validate that the energy conversion efficiency is highly improved due to the aforementioned three unique designs. The device has been fabricated by a CMOS compatible process. The generated energy can be efficiently accumulated as useful electricity over time and can prolong the battery life.

Jin Xie is an associate professor in Department of Mechanical Engineering, Zhejiang University. He received the B.Eng. degree from Tsinghua University, Beijing, China, in 2000, the M.Eng. degree from Zhejiang University, Hangzhou, China, in 2003, and the Ph.D. degree from Nanyang Technological University, Singapore in 2008. From 2007 to 2011, he worked in Institute of Microelectronics, Singapore, where he was a scientist in the Sensors and Actuators Microsystems Program. From June 2011 to July 2012, he worked as a post-doc researcher in the Department of Mechanical Engineering, University of California, Berkeley, CA, USA. His research interests include microelectromechanical systems (MEMS) design and processes, energy harvesters, inertial sensors, acoustics and vibration measurement.

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Invited Talk (3):

Solution Processable ZnO Nanostructured Materials Tailored for Sensor and Dye Sensitized Solar Cell

Applications

Ghim Wei Ho

Department of Electrical and Computer Engineering, National University of Singapore, Singapore

Biography of Presenting Author: Prof. Ghim Wei Ho

Abstract

ZnO nanostructured materials are fabricated on non-conventional substrates namely the plastic, textile and free-standing nanostructures paper. The ability to fabricate devices on these non-conventional substrates is important owing to the demands of handheld, portable consumer electronics. In addition, these non conventional substrates potentially possess many attractive properties including biocompatibility, flexibility, light weight, shock resistance, softness and transparency. However, most of these non conventional substrates have low melting point and tend to deform or melt at relatively low temperature which limits the synthesis temperature of nanostructures directly on these substrates. Low temperature hydrothermal synthesis processes have also been developed to overcome the limitation. Furthermore, to realize high performance ZnO based sensor and solar cell, detailed understanding and control over the growth, crystal structure, and transport properties of nanostructured materials on device performance is carried out. Compared to the commonly used nanoparticles, 1D nanowires film provide additional benefits of predefined, monodisperse length scale which enable optimized charge generation and collection through direct electron transport pathways.

Ghim Wei Ho graduated with a B.Sc and M.Sc from the National University of Singapore in 2000. She worked as an Engineer at Chartered Semiconductor Manufacturing (CSM), Singapore from 2000-2002, before undertaking her doctoral research on semiconductor nanostructures at the Nanoscience Centre, University of Cambridge from 2002-2005. She was elected as a Scholar at Selwyn College, University of Cambridge in 2002. Upon her completion of her Ph.D in 2005, she joined the Nanoscience Centre as a postdoctoral researcher. She subsequently joined NUS as an Assistant Professor in Electrical and Computer Engineering in May 2006.

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Invited Talk (4):

Efficient Inductive Power Transfer for Biomedical Applications

Yongxin Guo

Department of Electrical and Computer Engineering, National University of Singapore, Singapore

Biography of Presenting Author: Prof. Yongxin Guo

Abstract

Wireless power transfer (WPT) using inductive coupling is an essential method to power biomedical implants as it provides a hassle-free alternative to batteries and dangling wires. The power transfer efficiency (PTE) of the inductively coupled link is a key quality metric using which the link is evaluated. In this presentation, we address the various methods to improve the PTE of inductively coupled links and discuss the advantages and disadvantages of the different approaches in WPT links. In the meantime, coil misalignment and large separation between coils in wireless power transfer links that use inductive coupling have limited the wireless power transfer efficiency considerably. Motion artifacts leading to coil misalignments also result in intermittent power outage at the receiving coil. These issues will also be addressed by studying the concept of flux sharing.

Yong Xin Guo is an Assistant Professor with the Department of Electrical and Computer Engineering, National University of Singapore (NUS). From September 2001 to January 2009, he was with the Institute for Infocomm Research, Singapore, as a Research Scientist. He has authored 115 international journal papers and 122 international conference papers. His current research interests include microstrip antennas, implantable/wearable antennas, MMIC modeling and design, RF energy harvesting and wireless power. Dr Guo is the General Chair for IEEE MTT-S International Microwave Workshop Series 2013 (IMWS2013) on “RF and Wireless Technologies for biomedical and Healthcare Applications" in Singapore.

 

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Invited Talk (5):

Vibration-based MEMS Energy Harvesting Systems for Wireless

Biomedical Sensors

Huicong Liu Department of Electrical and Computer Engineering,

National University of Singapore, Singapore

Biography of Presenting Author: Dr. Huicong Liu

Abstract

Research on energy harvesting from human activities has addressed the feasibility of powering wearable or implantable systems. Biomedical sensors can take advantage of human-based activities as the energy source for energy harvesters. The development of energy harvesting sources such as piezoelectric, electrostatic, and electromagnetic energy transduction can convert mechanical energy (body movement such as walking, running, arm and finger motions, heartbeat, and blood flow pulse) into electrical energy. While harvesting energy through these approaches may offer an almost infinite lifetime of power for the biomedical sensors, these methods currently suffer from very low power efficiency compared to a conventional electrochemical battery. We have developed a vibration-based MEMS piezoelectric energy harvesting system with wide operation range to be adapted to power the wearable or implantable wireless biomedical sensors.

Huicong Liu is a research fellow at Lab of Sensors, MEMS and NEMS, Department of Electrical & Computer Engineering, National University of Singapore, Singapore. She received her B.Sc and M.Sc. degrees in Department of Mechanical Engineering from University of Science and Technology Beijing, China, in 2006 and 2008 respectively. She is expected to get her Ph.D. degree from the Department of Mechanical Engineering, National University of Singapore in Nov. 2012. Her research interests are vibration-based MEMS energy harvesters and self powered MEMS devices. She is currently working on energy harvesting solutions for wireless wearable biosensors for disease management and prevention-oriented healthcare.

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Invited Talk (6):

MEMS Multi-Electrode Array for Neural Signal Measurement

Da-Jeng Yao

National Tsing Hua University, Taiwan Biography of Presenting Author: Prof. Da-Jeng Yao

Abstract

This study developed several Multi-Electrode Array (MEA) by using different materials for different purpose of neural signal measurement, including silicon-based, glass based, and polymer-based MEA. The multi-walled carbon nanotubes (MWCNTs) was used to reduce the impedance of MEA. In the extracellular neural recording, the signal from dorsal side of lateral giant (LG) neuron of the America crayfish was recorded by electrical shocking on the tailfin efferent. The response amplitude of action potential was about around 100 μV or above, in which the recorded data is also marked by a signal-to-noise ratio (SNR) as high as 40.12 dB. The better performances of the electrode, the more feasible to separate neural signals and its shapes were recognized distinctly.

Da-Jeng Yao was born in Taipei, Taiwan in 1969. He received his Ph.D. from Department of Mechanical and Aerospace Engineering, University of California at Los Angeles (UCLA) in 2001. His dissertation focused on the design and fabrication of an in-plane MEMS thermoelectric microcooler, which serves to cool a microchip locally or to stabilize the temperature in biomedical applications. His research objective is to combine strong backgrounds in MEMS and thermal fluidics for micro science research. From a point of view of applications, BioMEMS and MEMS packaging are the focus of his research topics. From a point of view of fundamental science, thermo-fluidic MEMS and measurement of thin-film properties are his selected research topics. To build a multidisciplinary research team for the development of interdisciplinary technologies within his research scope is his ambition at National Tsing Hua University. He got the best patent and best paper award from Industrial Technology Research Institute (ITRI), Wu-Da-Yu Memorial Award (Young Investigator) from National Science Council in 2009, Shen-Yin award in 2010.

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Invited Talk (7):

Through the Clinician's Mind: Clinical-Engineering Integration Requires a Critical

Rethink of Fundamentals

Dr. Yee Sien NG Head of Dept. and Senior Consultant Physician;

Dept. of Rehabilitation Medicine; Singapore General Hospital, Singapore

Biography of Presenting Author: Dr. Yee Sien Ng

Abstract Engineering in Medicine (EIM) is a diverse, broad area and an exponential growth field critical to both Engineering and Medicine. However Medical-Engineering integration is problematic, patchy, under or overdeveloped in subareas resulting in unsettled foundations, stunted growth and extensive development of irrelevant devices. The first barrier discussed is how engineering solutions with increasing sophistication and complexity, have developed swiftly but in-congruently parallel to simultaneous rapid development of clinical sciences. We use the huge field of engineering approaches to disability and chronic disease as an example. Rapid increasing clinical knowledge of basic sciences in neuroplasticity and frailty result in paradigm changes in retraining rather than compensation in rehabilitation. However these are not grasped in the development of medtech devices leading to solutions that address the end-result of a disease process rather than addressing the root cause. The myriad of engineering products may secondarily lead to device fatigue amongst clinicians.

Dr Ng Yee Sien is currently the Head of Department and Senior Consultant in the Department of Rehabilitation Medicine at the Singapore General Hospital in Singapore. He also holds academic positions at both the Duke-NUS Graduate Medical School and the Yong Loo Lin School of Medicine at the National University of Singapore, and teaches medical, nursing and therapy students actively both in rehabilitation and general internal medicine. He obtained his medical degree in Singapore and obtained his post-graduate qualification in Internal Medicine from the United Kingdom (MRCP (UK)). He completed a fellowship in Neuro-Rehabilitation from Harvard Medical School in the US. His areas of specialization are in the Rehabilitation of Stroke and Traumatic Brain Injury as well as the management of spasticity. His research interests are in neurorehabilitation, weight-support devices for ambulation, robotics, virtual reality, as well as in functional outcomes in disability. He has published in international journals such as Stroke, Archives of Physical Medicine and Rehabilitation and NeuroRehabilitation. He is the Honorary Secretary of the Chapter of Rehabilitation Physicians of the Academy of Medicine in Singapore as well as an Executive Committee Member of the Society of Rehabilitation Medicine in Singapore.

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We next explore broadly the core work and key performance indicators of practicing clinicians and contrast to academic engineers and engineers in commercial industries; and demonstrate the conflicts and tension that result in misguided attempts to integrate. We explain why the health-care milieu does not incentivise the clinician to formulate interest in engineering. In addition, clinicians regularly do research to find answers to disease processes which are often in conflict with engineers needs to operationalize and build; and again in opposition to funding bodies and commercial companies aggressively driving for novelty and disruptive technology. This often manifests in widely differing apportions in funding requests between clinicians and engineers, as well as clinician vexation that only large novel projects are funded rather than more significant trials that require objective engineering measures on already developed technology. The third obstacle is the absence of clarity of the clinician's and engineer's role in such an integration. Although it is well recognized that engineering needs to target relevant clinical problems; the content and level of baseline knowledge and competence of EIM for both clinician and engineer is poorly defined. Several common levels knowledge may be required; and we take stroke as an example. Levels at least include firstly, knowledge of stroke pathology (clinician knowledge, engineers may not appreciate relevance); and secondly, active assistance or assist as needed as a solution to weakness in stroke (means different concepts to clinicians and engineers that need clarification prior to solution development). We propose 3 key solutions for discussion. Firstly, the development of an EIM division as a pan-engineering faculty body developing education pedagogy and appropriate syllabi at both undergraduate and post-graduate levels. Research funds should be directed at EIM education research. Innovative EIM teaching incorporating a systematic observation phase analogous to the need for detailed 'patient inspection' prior to medical examination and diagnosis may optimize learning and prevent 'rushing to solve'. We also present preliminary results from the first EIM course for engineering students taught by clinicians. Secondly, the development of concepts aimed at incorporating academic and service engineers in health-care settings and actual patient-care teams. A potential model is the engineer-in-residence scheme in a living laboratory within a hospital setting. Finally, the development of dedicated resourced integrated groups optimally at a national level to champion this field is critical to the development of EIM and minimize unnecessary resource-draining competition between individual academic institutions towards each other and the funding agencies and industry at large.

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Invited Talk (8):

A Shared-Control Microrobotic System for Microsurgeries with

Intelligent Control

Chee Kong Chui

National University of Singapore, Singapore Biography of Presenting Author: Prof. Chee Kong Chui

Abstract

Microsurgery can be performed using microrobots. The autonomous microrobots may remove the clinician from decision-making role due to poor information feedback. Intelligent visual and/or haptic cues are required so that the surgery can be intervened in a timely and effective manner. We have been developing augmented reality system for microrobots controlusing image overlay, importance-driven focus of attention based on of information theory and motion guidance based on imitation learning models.Although microsurgery is dominantly visual, the adaptive visual cues may compensate the lack of haptics in microsurgery. Our study on human centricity in a collaborative human-robot setting will also provide unique insights on human perceptual, cognitive, and motor skills.

Chui Chee Kong is an assistant professor with the Department of Mechanical Engineering at National University of Singapore and is interested in research and development of engineering systems and science for medical and surgical applications. He obtained his Ph.D. from Biomedical Precision Engineering Laboratory, The University of Tokyo in 2004. He was the principal investigator of the Biomedical Simulation & Device Design Project at an A*STAR research institution. He received several international research awards from his work on engineering in medicine. He is lead inventor of two patented human-computer interfacing apparatus and system, and is co-lead inventor of a patented medical device design methodology. He also has several patents pending on medical devices, robotics and simulation. Chee Kong has written and contributed to over 80 articles in journals and conferences.

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Invited Talk (9):

Surgical Instrument Tracking for Navigating Minimally Invasive

Surgery

Hongliang REN National University of Singapore,Singapore

Biography of Presenting Author: Prof. Hongliang Ren

Abstract

Surgical navigation and planning systems enable surgeons to carry out surgical interventions more accurately and less invasively, by tracking the surgical instruments with respect to the target anatomy. This talk will discuss several relevant aspects of this topic, such as a wireless navigation system primarily for endoscopic surgeries. In order to get the real-time position and orientation measurements of surgical instruments, we developed a miniature tracking device, free of the constraints of line-of-sight or entangling sensor wires. The proposed sensor fusion algorithm integrates the information from multiple miniature measurement units, such as inertial sensors, optical sensors and electromagnetic tracking sensors, based on the system dynamics and sensor models. Wedemonstrated that the miniaturized surgical instrument tracking system can facilitate more flexible minimally invasive surgery and meet the tracking requirements, in terms of tracking accuracy, latency and robustness.

Hongliang Ren is currently an assistant professor and a PI of medical mechatronics in National University of Singapore (NUS). Prior to joining NUS, he received his PhD in Electronic Engineering from The Chinese University of Hong Kong (CUHK), and followed by postdoctoral research in the LCSR and ERC-CISST labsofThe Johns Hopkins University, Surgical Innovation Institute of Children's National Medical Center, and the Pediatric Cardiac Bioengineering Lab of Children's Hospital Boston & Harvard Medical School.His research interests are in Computer-Integrated Surgical (CIS) systems, biomedical mechatronics, medical robotics and sensing technologies.

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Invited Talk (10):

Biomedical Implant System Design Enabled by MEMS and CMOS IC

Darrin J, Young

University of Utah, USA

Biography of Presenting Author: Prof. Darrin J. Young Abstract

Advancement in micro-electro-mechanical systems (MEMS) sensors, actuators, and low-power integrated electronics has fueled recent rapid development in wireless biomedical microsystem technologies. These technologies can provide real-time sensing, stimulation, communication and bio-control capabilities. Ultra low power dissipation enables battery-less bio-implantable devices with a small form factor powered by ambient energy sources. Such innovations are particularly crucial for biomedical implants, where size, weight, power, and limited access are critical constraints. Optimal design across system, device, circuit, and packaging is highly important for achieving a superior performance with high reliability. This talk presents a number of biomedical implant system design examples enabled by MEMS technology and low power CMOS integrated circuits.

Darrin J. Young received his B.S., M.S., and Ph.D. degrees from the Department of Electrical Engineering and Computer Sciences at University of California at Berkeley in 1991, 1993, and 1999, respectively. Dr. Young joined the Department of Electrical Engineering and Computer Science at Case Western Reserve University in 1999 as an assistant professor. In 2009 he joined the Electrical and Computer Engineering Department at the University of Utah as an USTAR associate professor. His interests include micro-electro-mechanical systems design, fabrication, and integrated circuits design for wireless sensing, biomedical implant, communication and general industrial applications as well as commercialization of wireless microsystems. He has published many technical papers in journals and conferences, and served as a technical program committee member and session chair for a number of international conferences. Dr. Young was an associate editor of the IEEE Journal of Solid-State Circuits and currently serves as the chair of the IEEE Electron Devices Society MEMS Committee.

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Invited Talk (11):

Manipulating Cell Behaviors via Functionalized Silicon Biochip

Chung-Yao Yang and J. Andrew Yeh

National Tsing Hua University, Taiwan Biography of Presenting Author: Prof. J. Andrew Yeh

Abstract

Understanding the interactions between single mammalian cell and the surface that these cells attach is one of the long-standing issues in various research communities. In this study, to probe cellular behaviors on a physiological-relevant situation at a nanometer scale, a widely used material—silicon with nanostructures—treated with a monolayer of a functional group was generated to examine cellular responses. We have demonstrated an IC-compatible approach which can be used to produce a large amount of functionalized silicon nanostructures via a combination of chemical etching and vapor deposition for mammalian cell micropatterning. Various cells were cultured onto a silicon substrate with nanostructures; the cells show distinct morphologies when culturing them on a specific pattern that we designed. Our results indicate that the nanometer-sized biocompatible substrate has the potential to provide a distinct in vitro environment and thereby facilitating a better understanding of cell behaviors.

J. Andrew Yeh received his BS in mechanical engineering from National Taiwan University, in 1992, and his MSs in mechanical engineering and electrical engineering in 1996 and 1997, respectively, and his PhD in electrical engineering in 1999 from Cornell University, Ithaca, New York Dr. Yeh joined National Tsing Hua University, Taiwan, in 2001 and is currently an associate professor at the Institute of Nanoengineering and Microsystems, where his interests are in the development of optical microsystems, nanophotonics, and sensors. In early 2000, he cofounded a microopto electro mechanical systems company, AIP Networks, Inc., in the United States. A postdoctoral associate at Cornell University in 1999, he has been serving as secretary general of Taiwan Section at the American Society of Mechanical Engineers (ASME) since 2006 and was the general chair of IEEE/LEOS Optical MEMS and Nanophotonics Conference 2007. He is also a member of Editorial Board, IEEE/ASME Journal of Microelectromechanical Systems since 2010.

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Invited Talk (12):

Electrical Stimulation in Neuro-chips

In-Hong Yang1,2

1John Hopkins University, USA 2SiNAPSE, National University of Singapore, Singapore

Biography of Presenting Author: Dr. In-Hong Yang

Abstract

In this talk, Dr. Yang will present his recent research findings. 1. Myelination and neuromuscular junction in a microfluidic platform: the

myelination by embryonic stem cell derived oligodendrocytes and Schwann cells can be induced in a novel microfluidic platform.

2. Role of Myosin II in axon guidance: the modification of growth cone can enhance the axon growth.I have analyzed axons guidance and gene expression in a novel microfluidic system. Axon specific drug can overcome the inhibitory molecules of axon growth.

3. Electrical stimulation of myelination: the development of an electrical stimulation device that can promote myelination and axon growth in a novel microfluidic compartmentalized platform.

Dr. YANG, In Hong is currently the principal investigator in SINAPSE at the National University of Singapore. He holds research faculty in the Biomedical Engineering at the Johns Hopkins university. He received his PhD from the Department of Biomedical Engineering at Texas A&M University in 2004. Dr. Yang's field of study over the last ten years has been nerve degeneration and regeneration. Dr. Yang has a particular interest in using microtechnology, Neuro-Chip, to study the repair and regeneration of diseased or damaged nerve tissue. It is Dr. Yang's long-term goal to continue to merge engineering principles and a problem-solving approach with the knowledge and experimental techniques of neuroscience to identify novel therapeutic targets for nerve degeneration. In particular, at SINAPSE (Singapore Institute for Neurotechnology), Dr. Yang is leading the Neuro-Chips division to develop novel microsystems, Neuro-Chip, to identify therapeutic targets for neurodegenerative disease.

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Invited Talk (13):

Strain Sensing Effects in Silicon Nanostructures

Dzung Viet Dao1, Tung Thanh Bui2, and Susumu Sugiyama3

1School of Engineering, Griffith University, Southport, QLD 4222, Australia 2Advanced Institute of Science and Technology (AIST), Tsukuba, Japan

3Ritsumeikan University, Kusatsu, Shiga, Japan Biography of Presenting Author: Prof. Dzung Viet Dao

Abstract

Nanostructured materials have attracted increasing attention in nanoelectromechanical systems (NEMS) technology because of its unique and interesting properties for highly sensitive physical and biochemical sensing applications. In this work, we report our recent study on top-down nanofabrication techniques to create nanostructured materials, such as silicon nanowire (SiNW) and photonic crystal (PhC) nano structures, as well as theoretical and experimental investigations of strain sensing effects in these nanostructures to show good potential for applications in highly sensitive nanomechanical sensing technology.

Dzung Viet Dao received the Bachelor’s degree in Informatics-Mechanical Engineering and the Master’s degree in Machinery Mechanics from Hanoi University of Technology (HUT) in 1995 and 1997, respectively, and the Ph.D. degree in Science and Engineering from Ritsumeikan University in 2003. He served as a Lecturer at the Faculty of Mechanical Engineering, HUT, from 1995 to 1999. In 1999, he joined Ritsumeikan University, where he was a Postdoctoral Fellow with the Micro Nano Integrated Devices Laboratory (Sugiyama Lab) from 2003 to 2006, a Lecturer from 2006 to 2007, and a Chair Professor from 2007 to 2011. From 2011 he became a Senior Lecturer of School of Engineering, Griffith University at Gold Coast Campus. His current research interests are the sensing effects in nanostructured materials, silicon & silicon carbide micromachined physical and mechanical sensors, micro actuators, integrated MEMS/NEMS technology, and Robotics.

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Invited Talk (14):

Droplet Microfluidics for High Throughput Diagnosis

Chia-Hung Chen

National University of Singapore, Singapore Biography of Presenting Author: Prof. Chia-Hung Chen

Abstract

With the need for greater specificity and sensitivity in cancer biomarker detection for diagnosis, the number of required data points increases exponentially, resulting in increasingly complex experimental design and analysis. In this research, we introduced an integrated microfluidic platform for accurate diagnosis. We developed an integrated microfluidic platform combining a droplet generator, a picoinjector and a biomolecule concentrator to offer a multiplexing and high-sensitivity bioassay in the droplets. The ability to gather statistical information over large amount of different(can reach ~1000) chemical reactions by using very small amount of clinical samples (~20�L) will allow the accurate detection of cancer biomarkers and will be utilized for searching for novel drugs in an effective way.

Chen Chia-Hung obtained his Ph.D. degree from the University of Cambridge, M.S. from Harvard University, B.S. from National Taiwan University and postdoctoral training at Massachusetts Institute of Technology before joining the faculty at National University of Singapore (NUS) in 2012. He is currently a Principal Investigator in Integrated Microfluidic Biotechnology Laboratory at NUS. Dr. Chen’s research is focused on integrated microfluidics bioassay, droplet based microfluidics, high throughput diagnostic, bio-medical chips for point of care testing and advanced biomaterials. Several of his research works are potentially in commercial development including an integrated microfluidic platform used for lung cancer biomarker detections.

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Invited Talk (15):

MEMS Scanners for Circumferential Scanning Endoscopic Probes

Guangya Zhou

National University of Singapore, Singapore Biography of Presenting Author: Prof. Guangya Zhou

Abstract

For some clinic applications including intravascular and gastrointestinal investigations, full circumferential scanning (FCS) is highly desired. Early research efforts on FCS such as proximal catheter actuation were capable of scanning at a relatively slow imaging rate with nonlinear motion due to the physical inertia, friction and compliance of the device. Here, we describe a new configuration that utilizes multiple parallel incident light beams to drastically reduce the required mechanical rotation angle to achieve circumferential scanning. Multiple fiber-pigtailed GRIN lens bundle is utilized to direct the focusing incident light beams to the slanted facets of a MEMS-driven pyramidal polygonal micro-reflector. Once the micro-reflector is driven to rotate, a circumferential light scan will be realized. A circumferential tissue image may be reconstructed by recording the data from multiple fiber optic “channels” sequentially or simultaneously.

Guangya Zhou is currently an associate professor with the Department of Mechanical Engineering at National University of Singapore. He received his BEng and PhD degrees in optical engineering from Zhejiang University in 1992 and 1997 respectively. His main research interests include MEMS/NEMS devices for optical applications, nanophotonics, miniature imaging systems, and micro optics.

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Invited Talk (16):

Advance in Light Microendoscopy

Wibool Piyawattanametha

Group Leader of Light Microscopy Team, National Electronics and Computer Technology

Center (NECTEC) Pathumthani, Thailand 12120

Director of Advanced Imaging Research (AIR) Center, Faculty of Medicine, Chulalongkorn

University (MD CU) Bangkok, Thailand 10330

Biography of Presenting Author: Prof. Wibool Piyawattanametha

Abstract Biomedical research truly needs new advances in imaging. Existing modalities of in vivo imaging, such as magnetic resonance imaging or ultrasound, lack the spatiotemporal resolution required to image the fundamental building block of living tissue. By contrast, existing high-resolution techniques for imaging cells and their sub-cellular features are technologies that are best suited for in vitro experiments in tissue slices. Yet, the ability to make direct connections between human pathological symptoms/behavior and the

Dr. Piyawattanametha received Ph.D. degree in Electrical Engineering from the University of California, Los Angeles, USA in 2004. From 2005 to 2009, he was with the Bio-X Program, Stanford University, Stanford, CA, USA as a senior scientist and later become an adjunct professor in 2010. Currently, he is with the National Electronics and Computer Technology Center (NECTEC), Pathumthani, Thailand, as a Group Leader of Cancer Imaging Consortium; the Faculty of Medicine, Chulalongkorn University, Pathumwan, Thailand, as the Director of Advanced Imaging Research (AIR) Center. He has authored or co-authored over 80 peer-reviewed publications, has contributed 8 book chapters and 4 patents in areas of Microelectromechanical Systems (MEMS), Photonics, and Biomedical Imaging. He serves as the technical program chairs and organizing chairs for the Society of Photo-Optical Instrumentation Engineers (SPIE) in Optical MEMS and Miniaturized Systems of Photonics West Conference, USA; International Conference on Bioinformatics and Biomedical Engineering (iCBBE), USA; the Institute of Electrical and Electronics Engineers (IEEE) Optical MEMS and Nanophotonics, USA; IEEE CYBER, USA; IEEE Nanoelectromechanical Systems (NEMS); and IEEE Nanomedicine (NANOMED), USA. He served as a co-editor of the SPIE MOEMS and Miniaturized System IX and the IEEE Journal of Microelectromechanical Systems.

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underlying cells and molecules responsible for such behavior requires in vivo techniques that can image cellular constituents. Our research aim is divided into two main projects. The first project is to develop high-resolution and portable optical endoscopes to satisfy unmet clinical diagnostic needs in vivo. These differ from medical endoscopes, which are generally larger and designed to image macroscopic abnormalities or ex vivo tissues. The microendoscopes are miniaturized into two form factors (5-mm and 10-mm diameter). The second project is on the development of a new probe for early detecting cervical cancer deriving from phage display peptide libraries. Therefore, the focus of my talk will be on the development of both the portable confocal microendoscope coupled with targeted peptide probes to improve early detection of cervical cancer in human patients. With combination in cancer screening, it might suggest new approaches to cancer disease diagnosis and treatment. The imaging demonstrations of the endoscopes were on both ex vivo and in vivo from mice and human.

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Oral Presentation Paper (1):

An 8-bit 128MSps Pipelined ADC Design for Ultrasound Needle

Application

Xiwei Huang1,2, Jia-Hao Cheong2, Hao Yu1, and Minkyu Je2 1School of Electrical & Electronic Engineering, Nanyang Technological University.

2Institute of Microelectronics, Singapore

Biography of Presenting Author: Mr. Xiwei Huang

Abstract

Ultrasound imaging has often been used in biomedical applications as a diagnostic tool due to its less-harmful characteristic, low cost and real-time imaging capability compared to X-ray, magnetic resonance imaging (MRI) and computed tomography (CT). In recent years, the development of Capacitive Micromachined Ultrasound Transducer (CMUT) technology also enables the easier system integration with readout electronic circuits. An 8-bit 128MSps pipelined analog-to-digital converter (ADC), designed for use in an integrated ultrasound needle imaging system, has been implemented in a 30V high voltage 0.18μm Bipolar/CMOS/DMOS (BCD) process. The simulation results show that the ADC achieves a signal-to-noise and distortion ratio (SNDR) of 47.7dB. The DNL/INL is within ±0.5/±0.8bits. The ADC consumes a total current of 38.75mA at 1.8V. The ADC is capable of digitizing 8 channels of time-gain control amplifier (TGC) output signal, each with an effective bandwidth as wide as 3.9MHz.

Xiwei Huang received the B.S. degree (with honors) from Beijing Institute of Technology, China, in 2009. He is now pursuing his Ph.D. degree in School of Electrical and Electronic Engineering at Nanyang Technological University, Singapore. His research interests include ultrasound analog front-end circuit design and microfluidics-based CMOS imaging circuit and system design for biomedical Lab-on-Chip applications.

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Oral Presentation Paper (2):

Fiber-optic Fluoroimmunoassay System for On-site Monitoring of

House Dust Mite Allergen

Kumiko Miyajima1,2, Keiko Tamari3, Elise Kiyomiya3, Takahiro Arakawa2, Hiroyuki Kudo1,2, Kiyoko Shiba3 and Kohji Mitsubayashi1,2

1 Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan

2 Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Japan 3 Faculty of Health Science Technology, Bunkyo Gakuin University, Japan

Biography of Presenting Author: Ms. Kumiko Miyajima Abstract

A fluoroimmunoassay system with optical fiber probes for house dust mite allergen (Dermatophagoides farinae: Der f1) was developed and applied to detection of Der f1 in actual house dust. The assay principle of the system is based on a sandwich immunoassay. Fluorophores (cyanine 5) labeled immune complexes at the surface of the optical fiber probe was excited by the evanescent light and detected by a photo diode. The calibration range of Der f1 was 1.95 to 250 ng/ml determined by the rate of fluorescence increase in the binding reaction of detection antibodies to Der f1. The assay was completed within 6 minutes which was more than 20 times faster than that of conventional ELISA method. The selectivity to other environmental allergens was also tested, and the system showed high specificity to Der f1. The immunoassay system was applied to detection of Der f1 in actual dust from household belongings. Calculated values of Der f1 showed good correlations between the fiber-optic fluoroimmunoassay and ELISA.

Kumiko Miyajima is an engineering official of Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (Department of Biomedical Devices and Instrumentation). She also is a PhD student in Department of Advanced Sciences and technology for Biomedical Sensors, Tokyo Medical and Dental University. Her research interests include immunoassay and clinical engineering.

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Oral Presentation Paper (3):

Insect Batteries Using Insect Hemolymph for Insect Robots

Kan Shoji1, Yoshitake Akiyama2, Masato Suzuki1, Nobuhumi Nakamura1, Hiroyuki Ohno1,

and Keisuke Morishima2 1Tokyo University of Agriculture and Technology, Japan

2Osaka University, Japan

Biography of Presenting Author: Mr. Kan Shoji

Abstract

This work reports the potentiality of a semi-permanent battery mounted on an insect which uses trehalose, the main sugar of insect hemolymph. Insects are extremely successful animals and can be regarded as one of the most perfect MEMS devices. Several groups have proposed and reported using a part of an insect or a whole insect to get a high performance sensor or a robot. However, batteries for insect robots has never been examined. Therefore, we have proposed and developed an insect biofuel cell using trehalose present in insect hemolymph. The insect battery generated electric power by oxidizing glucose which is obtained by hydrolyzing trehalose enzymatically. A maximum power density of 10.5 μW/cm2 was obtained from cockroach hemolymph with added trehalase and mutarotase [1]. The power output was kept at more than 10 % for 2.5 hours by protecting the electrodes with a dialysis membrane. In this study, we suggested a self-circulation system powered by a beating dorsal vessel to generate electric power continuously. A fluid drive was obtained by connecting a fluid channel between the anterior and posterior of the insect. [1] K. Shoji et al., Biomedical Microdevices, DOI: 10.1007/s10544-012-9706-z, (2012).

Kan Shoji received his bachelor’s degree in mechanical engineering at Tokyo University of Agriculture and Technology (TUAT) in 2011. He is currently a Ph.D. candidate at TUAT. His current research includes biofuel cells using blood sugar presents in insect hemolymph. He takes an interest in insect cyborgs, energy harvesting and microbial biofuel cells. He was awarded the Undergraduate Student Award at The 7th IEEE TYRW and the Atoda Award (Best Presentation Award) while at TUAT.

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Oral Presentation Paper (4):

Differentially-fed dual-band implantable antenna for biomedical

applications   

Zhu Duan1,2, Yong-Xin Guo1, Rui-Feng Xue2, Minkyu Je2,1, and Dim-Lee Kwong2,1 1. Department of Electrical and Computer Engineering, National University of Singapore,

Singapore

2. Institute of Microelectronics (IME), A*STAR, Singapore

Biography of Presenting Author: Mr. Zhu Duan Abstract

A novel differentially-fed dual-band implantable antenna is proposed for the first time for a fully implantable neuro-microsystem. The antenna operates at two center frequencies of 433.9 MHz and 542.4 MHz, which are close to 402-405 MHz Medical Implant Communication Services (MICS) band, to support sub-GHz wideband communication for high-data rate implantable neural recording application. The size of the antenna is 480.06 mm3 (27 mm × 14 mm × 1.27 mm). The simulated and measured bandwidths are 7.3 % and 7.9 % at the first resonant frequency, 5.4 % and 6.4 % at the second resonant frequency. The radiation pattern and the Specific Absorption Rate (SAR) distribution induced by the implanted antenna inside a tissue-mimicking solution are evaluated. The performance of the communication link between the implanted antenna and external half-wavelength dual-band dipole is also examined.

Zhu Duan was born in Xianning, Hubei, China, in 1987. He received the B.S. degree from Department of Electronic Science & Technology, Huazhong University of Science and Technology (HUST), Wuhan, Hubei, China in 2009. He is currently working toward the Ph.D. degree at National University of Singapore (NUS), Singapore. Since Aug 2009, he has been with the Department of Electrical and Computer Engineering, National University of Singapore (NUS) and Institute of Microelectronics (IME), A*STAR, Singapore. His main research interests include implantable antennas and wireless power transfer for biomedical applications.

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Oral Presentation Paper (5):

CMOS-Based Electrical Stimulation Circuit System for Biomedical

Applications

Lei Yao1, Xu Liu2, Peng Li1, Yong Ping Xu2 and Minkyu Je1 1Institute of Microelectronics, A*STAR, Singapore

2National University of Singapore, Singapore

Biography of Presenting Author: Dr. Lei Yao

Abstract

Electrical stimulation has been used as an effective clinical treatment in many biomedical applications for a historical span of more than 50 years. Modern electrical stimulation system requires miniaturized and powerful circuit system to make the whole stimulation system implantable and versatile. CMOS technology is one of the best candidates to realize the circuit system to meet the above-mentioned requirements. In this paper, the design considerations for electrical stimulation systems are reviewed and discussed, and a multi-channel current-mode stimulation circuit system with arbitrary waveform and active charge balancing circuit in CMOS 0.18µm 24V high voltage (HV) process is presented. The arbitrary waveform has 5-bit voltage resolution with a compliance voltage of 24V. The active charge balancing circuit block has 100mV safety window based on the pulse insertion technique. In-vivo testing results demonstrates successful muscle recruitment on rat model using the proposed CMOS-based electrical stimulation system with arbitrary waveforms and pulse insertion based active charge balancing.

Lei Yao received B.S. degree in applied physics from University of Science and Technology of China, China, in 2004, and M.E. degree in microelectronics and solid-state electronics from Chinese Academy of Sciences, China, in 2007. He received his Ph.D. degree in electrical and computer engineering from McGill University, Canada, in 2010. He is currently working as a research scientist at Institute of Microelectronics, Singapore. His current research is focused on mixed-signal IC and system design for biomedical applications.

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Oral Presentation Paper (6):

A Miniaturized Tactile Sensor ASIC for a Sensorized Guide Wire in

Minimally Invasive Surgical Operations

Simon Sheung Yan Ng, Chee Keong Ho, and Minkyu Je

Institute of Microelectronics, A*STAR, Singapore Biography of Presenting Author: Dr. Simon Ng Abstract

A miniaturized high precision tactile sensor system is developed to increase the success rate of the guide wire passage through the lesion in minimally invasive surgical operations. The force exerted at the tip of the guide wire is detected by four Silicon Nanowire (SiNW) sensors and presented as a resistance value. The resistance is then converted to current pulses using a high precision programmable ASIC with an incremental double sampling second-order single-OTA Delta-Sigma () Analog to Digital Converter (ADC). The information is then transmitted to the external monitoring module through a 3-wire interconnect, which also serves as power supplies for the ASIC. The external monitoring module consists of two main parts, a 2-bit Digital to Analog Converter (DAC) for sending command to the ASIC and a current to voltage demodulation circuit that converts the modulated ASIC current output to voltage level for digital back-end processing. The digital back-end processing is performed using National Instrument (NI) Data Acquisition Card and Labview system. Measurement data shows that our tactile sensor system is capable of detecting force as small as 3mN.

Simon Sheung Yan Ng received a B.S. with Cum Laude Honor, M.S. and Ph.D. degrees in Electrical and Computer Engineering from the Ohio State University, Columbus Ohio, in 2005, 2006 and 2009 respectively. Since 2010, he has been working with Institute of Microelectronics, ASTAR, Singapore, as a Research Scientist. His recent researches focus on the development of ultra-miniaturized ASIC for different biomedical applications.

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Oral Presentation Paper (7):

Design of Inductive Coupling in Wireless Power Transfer for

Neurodevices

Rui-Feng Xue1, Zhu Duan2, and Minkyu Je1 1Institute of Microelectronics (IME), A*STAR (Agency for Science, Technology and

Research), Singapore 2National University of Singapore, Singapore

Biography of Presenting Author: Dr. Rui-Feng Xue Abstract Wireless power transfer to implantable biomedical devices can provide a safer and more robust implementation. Its efficiency should be maximized so that less transmitting power is required and/or a longer distance between the external transmitting device and the implant device can be facilitated with the same transmitting power. High efficiency is also good for living tissue safety and electromagnetic compatibility. Inductive coupling usually has quite a low efficiency on account of unfavorable coupling conditions such as size constraint, power requirement and biocompatibility. The design of an efficient link with the bidirectional communication capability is presented here, which can maintain high efficiency over the power range and is compact, easy for tuning and integration for mass production, as well as biocompatible without ferromagnetic core or high resonant current induced. The coexistence of the powering link with the data link or other sensing and interfacing blocks is also highlighted. This discussion can be applicable to bioelectronics and other potential industrial applications where wireless power transfer is needed.

Rui-Feng Xue received the Ph. D. degree in electronics engineering from Shanghai Jiao Tong University, Shanghai, China, in 2005. From 2005 to 2010, he was a Senior Engineer / Manager with Samsung Electronics Co. Ltd., Suwon, Korea, where he was engaged in the R&D of CMOS RF/analog integrated circuits (ICs). Since 2010 he has been a Scientist with Institute of Microelectronics, Agency for Science, Technology, and Research (A*STAR), Singapore, where he currently acts as a Principle Investigator of the wireless power transfer for implantable biomedical systems. His research interests include CMOS RF/Analog IC, RF and antenna system, and biomedical electronics. He was awarded the gold prize at the inaugural Chip Design Competition, Singapore, held in conjunction with the 13th International Symposium of Integrated Circuits (ISIC), 2011.

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Oral Presentation Paper (8):

A Smart Electrode Array Device with CMOS Microchip for Neural Interface

Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, and Jun Ohta

Nara Institute of Science and Technology, Japan Biography of Presenting Author: Prof. Toshihiko Noda

Abstract

A CMOS-integrated flexible neural interface device was designed and fabricated. The device enables electrical stimulation of neural tissues using an array of smart electrodes. The smart electrode consists of a CMOS microchip and a platinum stimulus electrode which are hybrid-mounted onto a flexible substrate. The smart electrodes have versatile functions due to the use of a dedicated CMOS microchip. Stimulus current generation and control logic circuits are integrated into the dedicated CMOS microchip. These multiple smart electrodes also provide the array with sophisticated functions with only four wiring connections to external equipment. Moreover, the hybrid mount architecture of microchips and stimulus electrodes is highly flexible and has low invasiveness to living body tissue. We focused on retinal prosthesis as one of the applications of the fabricated device. An in vivo evaluation of retinal stimulation was performed after implanting the device in the eye of an experimental animal. The stimulus function of the device was successfully demonstrated by observing responses of electrically-evoked potentials (EEP) in the visual cortex caused by the stimulation. Specific peaks in the EEP as a result of the retinal stimulation were observed. The promising application of the device as a retinal prosthesis was demonstrated.

Toshihiko Noda received Ph.D. degree in engineering in 2006 from Toyohashi University of Technology, Aichi, Japan. He was a post doctoral researcher from 2006 to 2007, and joined the faculty of Toyohashi University of Technology from 2008 as an assistant professor. Since 2009, he has been an assistant professor in Nara Institute of Science and Technology. His current research interests focus on retinal prosthesis devices and bio-imaging with CMOS image sensors.

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Oral Presentation Paper (9):

Bionic Neural Link for Peripheral Nerve Prothesis

Kian Ann Ng1, Xu Liu1, Jianming Zhao1, Li Xuchuan1, Shih-Cheng Yen1, , Yong Ping Xu1,

Ter Chyan Tan2, and Minkyu Je3

1Dept of Electrical and Computer Engineering, National University of Singapore, Singapore 2Dept of Hand & Reconstructive Microsurgery, National University Hospital, Singapore

3Institute of Microelectronics, A*STAR, Singapore

Biography of Presenting Author: Mr. Kian Ann Ng Abstract

Peripheral nerve (PN) injuries, such as brachial plexus nerve damage, are highly debilitating medical conditions. PN injuries with large gaps and long nerve regrowth paths are difficult to repair using existing surgical techniques, due to nerve degeneration and muscle atrophy. A Bionic Neural Link (BNL) as an alternative way for peripheral nerve repair is presented. The concept of the BNL is described, along with current VLSI implementations in standard CMOS process. In-vitro experimental results based on VLSI implementations will be presented. Full function of the BNL will also be demonstrated with in-vivo experimental results.

Kian Ann Ng was born in Singapore. He received the B.E. degree in electrical and electronic engineering and the M.E. degree in IC design in Nanyang Technological University, Singapore, in 2000 and 2005,respectively. From 2000 to 2009, he has designed numerous high performance analog ICs with the following companies: STMicroelectrionics, Chartered Semiconductor Manufacturing and Oxford Semiconductor. Currently, he is a Research Associate at the National University of Singapore. He is also a PhD candidate with the same University. His main research interest includes high performance biomedical circuits, precision analog circuits, switched-capacitor circuits, and RF identification circuits.

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Oral Presentation Paper (10):

IMMU-based Gait Phase Detection using Hidden Markov Model

Xiaoli Meng1,2, and Haoyong Yu1,2

1SiNAPSE, National University of Singapore, Singapore 2Department of Bioengineering, National University of Singapore

Biography of Presenting Author: Dr. Xiaoli Meng

Abstract

After stroke, many individuals suffer from chronic motor dysfunction in the lower extremity. We are developing a lower limb exoskeleton robot for gait rehabilitation. Detecting the gait phase allows finding the proper timing for providing the assistance to the stroke patients. In this paper, we proposed a gait phase detection algorithm using Hidden Markov Model (HMM) to identify the seven gait phases in over ground walking. Three MARG (magnetic, angular rate and gravity) sensor modules were used to obtain knee angle and foot angular rate patterns. HMM is introduced to distinguish gait phases based on the features from the observed data. Experiments were carried out on 3 adult healthy subjects walking in the monitor area of a reference optical motion capture system. Detection accuracy was evaluated by the benchmark provided by the reference system. The detected gait information can also be used to assess the rehabilitation performance of the stroke patients by the stimulation. Specific peaks in the EEP as a result of the retinal stimulation were observed. The promising application of the device as a retinal prosthesis was demonstrated.

Xiaoli Meng is a Research Fellow at Singapore Institute for Neurotechnology (SiNAPSE) and Department of Bioengineering, National University of Singapore. In 2012, she has been awarded her Ph.D. in Electrical Engineering from Chinese Academy of Sciences. Her current research focuses on the development of human lower body exoskeleton for rehabilitation and sensory-motor control strategies.

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Oral Presentation Paper (11):

Optimal Thickness Ratio Study for AlN CMUT- a Simulation Study

M. J. Wang1,2, A. B. Randles2, J. M. Tsai2, Y.F. Zhou1

1 School of Mechanical & Aerospace Engineering, Nanyang Technological University, Singapore

2Institute of Microelectronics, A*STAR, Singapore

Biography of Presenting Author: Mr. Mingjun Wang Abstract When a thin layer of AlN was added to the top of the membrane of capacitive micromachined ultrasonic transducers (CMUT), many characteristics of the device are altered. Tuning is done by applying different voltages to the AlN layer. Since the potential application for AlN CMUT was for high intensity focused ultrasound ablation, the acoustic pressure was the key factor for this application. In this paper we first demonstrate that AlN CMUT has the abilities to generate high output pressure, and then several optimization studies were conducted to find the optimal dimensions of the device, especially the ratio of the AlN thickness to the membrane thickness. The simulation results shows that a large AC driving signal was essential for high output pressure; the AlN CMUT shows a superior performance in terms of the high output pressure compared to the conventional CMUT. So far, a resonant frequency shifting due to the voltages that applied to the AlN layer was observed; what’s more, a 6 MPa peak to peak simulation pressure was obtained by a 100VDC plus a 160VAC working at 2.8MHz, which was high enough for the HIFU ablation A 10% output pressure increase was obtained by applying 100 V to the AlN layer.

Mingjun Wang was born in Sichuan China. He received the B.S degree in mechanical engineering in 2010 from Northwestern Polytechnical University, Xi’an China. He is currently working towards the Ph.D degree in electrical engineering in Nanyang technological university and was attached to the Institute of Microelectronics, A*Star, Singapore. He is currently involved in capacitive micromachined ultrasonic transducers (CMUTs) for high intensity focused ultrasound (HIFU ablation.

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Oral Presentation Paper (12):

Accurately Charge Balanced Neuro-Stimulator with Wireless Power

Delivery System

Sudip Nag1,2, Nitish Thakor1,3 and Dinesh Sharma2 1SiNAPSE, National University of Singapore, Singapore

2Indian Institute of Technology Bombay, India 3Johns Hopkins University, USA

Biography of Presenting Author: Mr. Sudip Nag

Abstract

Functional Electrical Stimulation (FES) is a widely adopted method for therapeutic intervention and functional restoration of neuronal systems, such as, in brain, retina, cochlea and peripheral nerve. FES utilizes electrical charges that are presented through electrical stimulators. Total injected charges to neurons must be zero for biological safety reason. Existing approaches are incapable to assure such feature in long term and continual stimulations. We present an improved electrical stimulator architecture using floating current sources and steering diodes to achieve better than 5.6 fC accuracy while delivering 140 nC per phase. Programmable stimulation currents up to 1.4 mA have been shown possible with less than a 27 pA mismatch between the positive and negative phases. The system operates in monopolar or bipolar modes, and can generate anodic-first or cathodic-first biphasic pulses, with or without inter-phase delays. The architecture bypasses blocking capacitors, shorting of electrodes and critical feedbacks. 134.2KHz operated inductive energy harvester has been added to power the stimulator. The harvesting system delivers 1.4 mW at 1 cm distance to an equivalent of 10 K load. The stimulator has been characterized with Randell’s equivalent (RC) impedances and Ag-AgCl electrodes. In-vivo stimulations have been shown possible with the rodent sciatic nerve. The presented system is suitable for implantable and real-life neuro-engineering applications.

Sudip Nag is an interim Research Assistant (joining as Research Fellow) at the Singapore Institute for Neurotechnology (SINAPSE) under the National University of Singapore (NUS). He is in the process of submitting the PhD thesis at the Electrical Engineering Department of Indian Institute of Technology (IIT) Bombay, India. His current research focuses on wirelessly powered electrical and optical stimulators for neuro-engineering and rehabilitation applications.

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Oral Presentation Paper (13):

A Programmable Gain Amplifier for Monolithically Integrated MEMS

Pressure Sensor IC

Arup K. George1, 2, Wai Pan Chan1, Gao Yuan1, Zhi Hui Kong2, and Minkyu Je1 1Institute of Microelectronics, A*STAR, Singapore

2School of EEE, Nanyang Technological University, Singapore Biography of Presenting Author: Mr. Arup K. George Abstract

Sensors and associated read-out electronics are traditionally fabricated separately and wire-bonded to each other for bio-medical applications such as intra-cranial pressure measurement. However, integrating the sensors and the interface circuits on the same die have gained prominence in the recent times as different kind of sensors could be fabricated, thereby increasing the functionality, while reducing cost. Pressure sensors could be developed by a post-CMOS process on the die after the circuit fabrication. Typically, such sensors have very low sensitivities and their performance is limited by the parasitics. Additionally, manufacturing tolerances could result in sensitivities that could vary over an order of magnitude than the designed one. In order to meet the output range requirements for such cases, it is necessary that the interface circuit needs a programmable gain. In this paper, we propose a simple scheme to adjust the gain of an interface circuit so that it can meet the output range requirements for a large amount of sensitivity variation.

Arup K. George received his B.Tech in Electrical and Electronics Engineering from Cochin University of Science and Technology, India in 2003. From 2003 to 2009 he was working as a Sr. Design Engineer developing MPEG-2, MPEG-4 and H.264 video algorithms on ARM based SoCs. During his career at NVIDIA, he contributed to the video firmware of their mobile platform SoC, Tegra. He received his MSc. in Electrical and Electronics Engineering with Distinction from the University of Glasgow, UK in 2010. Currently, he is pursuing his PhD at Nanyang Technological University, focusing on sensor interfaces for bio-medical applications.

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Oral Presentation Paper (14):

Wireless Power Transfer for Biomedical Implants

Rangarajan Jegadeesan, and Yong-Xin Guo,

Electrical and Computer Engineering Department, National University of Singapore, Singapore

Biography of Presenting Author: Mr. Rangarajan Jegadeesan

Abstract

Biomedical implants have become ubiquitous in today’s world. Wirelessly powering such implants helps eliminate the need for invasive wires. Wireless Power Transfer presents itself as an aesthetic alternative which can safely deliver power required for the implant to be functional. Magnetic near field coupling has been the most widely used method for wirelessly powering implants due to its high power transfer efficiency over short separations. In this work, we present the analysis of such wireless power links thereby providing guidelines on the usage of right topology, frequency of operation and coil dimensions. The choice of near field or far field power transfer that suits a particular implant application has been discussed based on the typical separation between the transmitter and receiver, their dimensions and the targeted power level. The retinal implant application is chosen to showcase the method to come up with the optimal wireless power link and the results are verified by simulations from HFSS and ADS.

Rangarajan Jegadeesan received the B.E. degree in electronics and communication engineering from the College of Engineering Guindy, Anna University, Chennai, India, in 2007. He is currently working towards the Ph.D. degree at the National University of Singapore. He joined Cypress Semiconductor Corporation in 2007 as a Product Engineer working on post silicon characterization. He later worked as an Application Engineer developing touch screen solutions and low data rate RF transceiver systems. He works as a freelance consultant for touch screen design and development. His research interests include wireless power transmission, RF energy harvesting, RFID, biomedical implants and safety, near-field sensing, and antennas for biomedical applications.

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Oral Presentation Paper (15):

Patient Specific Control of Insulin Delivery for an Artificial Pancreas

Yvonne Ho, and Chee-Kong Chui

Department of Mechanical Engineering, National University of Singapore, Singapore

Biography of Presenting Author: Ms. Yvonne Ho

Abstract

This paper presents a prototype implantable artificial pancreas with an advanced drug delivery mechanism, and a framework for patient specific continuous insulin therapy for blood glucose regulation, in which the parameters of the model used in predictive control are patient specific and can be calibrated regularly.

Yvonne Ho is a graduate student at the Department of Mechanical Engineering, National University of Singapore. Her current research work is on the artificial pancreas, more specifically on the applications of bio-inspired algorithms to blood glucose regulation.

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Bio4Apps Poster Paper (1):

Lensless Digital Fluorescent Detector using CMOS Image Sensor

Hironari Takehara1, Daisuke Okabayashi1, Toshihiko Noda1,

Kiyotaka Sasagawa1,Takashi Tokuda1, Soo Hyeon Kim2, Ryota Iino2, Hiroyuki Noji2 and Jun Ohta1

1Nara Institute of Science and Technology, Japan 2The University of Tokyo, Japan

Biography of Presenting Author: Mr. Hironari Takehara

Abstract

We fabricated a lensless complementary metal–oxide–semiconductor (CMOS) image sensor for fluorescent imaging. Recently beads-based digital enzyme-linked immunosorbent assay (ELISA)–which has ability of single molecule detection–has been used for highly sensitive and earlier diagnosis of diseases and infections. In the conventional digital ELISA system, a fluorescence microscope is used to detect the microbeads with target molecules, which are captured in the femto-liter chambers. For practical use, a simple and portable system is necessary. We propose to use CMOS image sensors for this purpose. The lensless image sensor is composed of CMOS image sensor chip, interference filter for eliminating excitation light, and femto-liter chamber array for trapping microbeads. In each femto-liter chamber antigen-antibody reaction can occur individually. We detected fluorescent and nonfluorescent microbeads with this sensor and showed its capability for counting the number of fluorescent chambers. The lensless CMOS image sensor system is applicable for bead-based digital ELISA.

Hironari Takehara received the B.E. (1984) and M.E. (1986) in applied chemistry from Kansai University, Japan. In 1986, he joined Panasonic Corporation, Kyoto, Japan (1986-2012), where he was a semiconductor process engineer. He has developed mixed-signal BiCMOS, high voltage SOI and optoelectronic IC processes. He also has been engaged in improvement of on-chip ESD protection for mixed-signal ICs. Since 2012, he is working toward the PhD degree at the Nara Institute of Science and Technology, Nara, Japan.

78

Bio4Apps Poster Paper (2):

Study of a Controlling of pH Sensitivity Using Hydrogen Annealing for a Long

Term pH Measurement

Masato Futagawa1, Makoto Takahashi2, Keita Kamado2, Makoto Ishida2, and Kazuaki Sawada2

1 Head Office for "Tailor-Made and Baton-Zone" Graduate Course, Toyohashi University of Technology, Japan

2 Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Japan

Biography of Presenting Author: Dr. Masato Futagawa

Abstract

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The ion-sensitive field effect transistor (ISFET) for pH measurement is one of the most important technologies to analyze biological and chemical action. For long term measurement, reference FET (REFET) had been studied in many groups to avoid the use of grass reference electrode. Their studies had been successful of compensating a fluctuation of potential voltage of target solution. However, an output signal drift occur by ion diffusion in the sensing membrane and all that didn’t have been enough to cancel it. We recommended a new REFET which was of a same sensing membrane (Si3N4) and structure as ISFET, and of only different pH sensitivity. The purpose of this study is of realization of pH sensitivity reduction using hydrogen annealing to Si3N4 film. Si3N4 on SiO2 on Si substrate structures were fabricated using LSI technology. The sample chips with and without H2 annealing (400 °C, 20 min) which is normally used in LSI process to recover defects in interface between SiO2 and Si was fabricated. The pH sensitivity was measured by C-V calculation for monitoring threshold voltage change by pH change. We confirmed a reduction 15 mV/pH by comparison between the chips with and without the annealing.

Masato Futagawa was born in Kagawa, Japan in 1977. He received Bachelor’s and Master’s degrees, in electrical and electronic engineering from Toyohashi University of Technology, Japan, in 2000 and 2002, respectively. He joined Toshiba Corporation from 2002 to 2007. He received Ph.D. degree in electrical and electronic engineering at Toyohashi University of Technology in 2011. He is now Project Assistant Professor in the university. His current research interests focus on multimodal sensor integrated with pH, ion concentration, water content, REDOX sensor in the area of bio-, agricultural- and environmental- sensors.

79

Bio4Apps Poster Paper (3):

Reduction of Sensitivity Variation in a Filter-less Fluorescence Detector for

Bio Applications

H. Nakazawa 1,2, K. Yamasaki 1, N. Misawa 1,3, M. Ishida 1,3 and K. Sawada 1,3,4 1Toyohashi University of Technology (TUT), Japan

2Japan Society for the Promotion of Science, Japan 3Electronics Inspired-Interdisciplinary Research Institute, TUT, Japan

4CREST, Japan Science and Technology Agency, Japan

Biography of Presenting Author: Dr. Hirokazu Nakazawa

Abstract

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picture here 

A filter-less fluorescence detector which is low sensitivity-variation is proposed and successfully demonstrated. By controlling sensitivity variation, the devised sensor is applicable to bio applications such as single nucleotide polymorphism analysis (SNP analysis).

Previously, we developed a filter-less fluorescence detector which detects two different wavelength lights, without using optical filters or gratings [1, 2]. Moreover, the developed sensor is applied to SNP analysis [3]. However, the accuracy is short of the level needed for practical use because of sensitivity variation by dark-current noise. In this novel method, the developed sensor employs the noise reduction techniques for controlling sensitivity variation.

[1] Y. Maruyama et al., A Novel Filterless Fluorescence Detection Sensor for DNA Analysis,

IEEE Trans. E.D., Vol. 53, No. 3, pp. 553-558, 2006. [2] Y. Maruyama et al., The fabrication of filter-less fluorescence detection sensor array

using CMOS image sensor technique, Sens. Actuators A, Vol. 128, pp. 66-70, 2006. [3] K. Yamasaki et al., Proposal for a Filterless Fluorescence Sensor for SNP genotyping,

Proceedings of the 5th International Joint Conference on BIOSTEC, pp. 185-189, 2012.

Hirokazu Nakazawa was born in Aichi, Japan in 1984. He received the Ph.D. degree in electronic and information engineering in 2012, from Toyohashi University of Technology, Aichi, Japan. From 2011, he is a Research Fellow of the Japan Society for the Promotion of Science. His current research interests focus on the development of multimodal bio-imaging sensors.

80

Bio4Apps Poster Paper (4):

Computational Analysis of Transient Particle with Applications to High-

throughput Coulter Counter Designs

Jinhong Guo1,2, Tze Sian Pui2, Abdur Rub Abdur Rahman2, and Yuejun Kang1

1 School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore

2.Institute of Microelectronics, A*STAR, Singapore

Biography of Presenting Author: Mr. Jinhong Guo

Abstract

Coulter Counter can provide direct information of ex vivo or in vivo cell. By characterizing the electrical pulse profile caused by cell, the size and numbers can be determined. The main limiting factor of contemporary counter device is throughput. In this paper, we present a novel solid-state Coulter counter working under low direct current (DC) voltage. The electrical pulse profiles induced by single or aggregated particles are numerically analyzed. The hydrodynamic force and electrokinetic force acting on each particle are quantitatively evaluated. When particles stick together, they cause a broader bandwidth and higher amplitude. When referring to the throughput, we proposed a design of Coulter Counter Array and simulated the electrical cross-talk due to the interference of neighbor microchannel. This numerical analysis provides an important guidance for researchers who are developing the commercial single or multiple microchannels Coulter Counter.

Jinhong Guo received his B.E. in Electronic Engineering in 2010 from the University of Electronic Science and Technology of China, China and is pursuing his Ph.D. degree in Biomedical Engineering in Nanyang Technological University, Singapore. He is currently a Ph.D. student at NTU jointly Institute of Microelectronics, A*STAR, Singapore. His research interests include solid-state biosensor, Microfluidic Electronics.

81

Bio4Apps Poster Paper (5):

Enhancement of Nanoelectronic Sensor Performance with Microfluidic

Device

Kyungsup Han1,2, Yong-Jin Yoon2, Jack Sheng Kee1, Mi Kyoung Park1 1Institute of Microelectronics, A*STAR, Singapore

2School of Mechanical and Aerospace Engineering, Nanyang Technological University. Singapore

Biography of Presenting Author: Mr. Han Kyungsup

Abstract

Biosensors are widely used as an analytical device to detect biomolecules through various signals in fields of medical, food, military and environmental applications. Especially, the biosensor have been actively studied for detection of biomolecules including viruses, proteins, cells and DNAs in the field of medical diagnostics. For the real-time and label-free sensing in one platform system, biosensors are positively integrated with microfluidic devices to transport the biomolecules. In terms of the binding probability, one of ways to improve it is a transportation of prove molecules near target molecules in biosensors by decreasing a height of the microfluidic device. The height-reduced microfluidic device, however, has a critical drawback which is high pressure drop in the microfluidic channel increased as square of ratio of height-reduced of the microfluidic device. For that reason, high pressure drop becomes more serious problem to operate the microfluidic device in case of the height-reduced microfluidic device and development of method enabling to enhance the binding kinetics and maintain bonding of the microfluidic device is necessary. Therefore, we suggest a method for enhancement of the binding kinetics of biomolecules with low pressure drop and validate the method through a simulation result.

CHUNG-ANG UNIVERSITY, Seoul, Korea Master of Science in Mechanical Engineering, Aug 2011 Bachelor of Science in Mechanical Engineering, Aug 2009

82

Bio4Apps Poster Paper (6):

Investigating the mechanical interaction between neural electrode

and brain tissue

Nader Hamzavi1,2, W.M. Tsang2, Victor P.W. Shim1

1 Department of Mechanical Engineering, National University of Singapore, 2 Institute of Microelectronics, A*STAR

Biography of Presenting Author: Mr. Nader Hamzavi Abstract

Over the past two decades, the study of brain-computer-interface (BCI) has continued to be a topic of intensive research efforts as it can help tetraplegia individuals to regain the ability to interact with their environment. One of the greatest challenges of the BCI is to have a high performance and reliable neural electrode interface. While invasive neural electrodes provide better signal resolution compared to non-invasive methods (e.g. EEG), they display a continuously degrading performance after implantation. It is possibly attributed to the tissue response with respect to the implanted electrode. The tissue response is characterized by the formation of a dense cellular sheath around the electrode, which results in dramatic increases in electrode impedance and loss of neuronal cell bodies around the electrode. It is generally believed that the tissue response is triggered by mechanically induced trauma associated with the electrode insertion and the strain on tissue due to the sustaining micro-motion at the electrode-tissue interface tissue. Hence, it is of great interest to understand the mechanical interaction between the electrode and tissue. Currently, we are developing a finite-element model to predict the strain distribution in the brain tissue with the electrode insertion of various speeds and micro-motion at electrode-interface of various electrode geometries and stiffness. Also, we are studying the effect of electrode insertion speed on the strain induced in a brain phantom material (agar gel) using an image correlation technique. We will compare the experimental results from the phantom material to the computer modeling results to improve the accuracy of the model. Our results can provide an insight to optimize the electrode design and the insertion process thus reducing the tissue response.

Nader Hamzavi is a PhD student in mechanical engineering department of NUS and he is also attached to Institute of Microelectronics A*STAR. He received his B.S. in solid mechanics from Shiraz University, Iran (2007) and a M.Eng. in mechanical engineering from NUS (2010). His research interests include biomedical engineering, robotics, computational mechanics and specifically soft tissue modeling. In current work, he is studying the mechanical interaction between neural electrode and brain tissue.

83

Bio4Apps Poster Paper (7):

Development of a ring-shaped tri-axial tactile sensor for minimally

invasive surgery applications

Beibei Han1, 2, Yong-Jin Yoon2, Muhammad Hamidullah1, Angel Tsu-Hui Lin1, and Woo-Tae Park3

1Institute of Microelectronics (IME), A*STAR, Singapore 2School of Mechanical and Aerospace Eng., Nanyang Technological University, Singapore

3Department of Mechanical and Automotive Engineering, Seoul National University of Science and Technology, South Korea

Biography of Presenting Author: Ms. Beibei Han

Abstract

The design of a ring-shaped tri-axial force sensor for minimally invasive surgery (MIS) applications is presented in this paper. The designed sensor comprises a ring-shaped structure located at the center of four suspended cantilever beams. The ring-shaped design allows cylindrical surgical tools to be easily passed through which largely simplified the sensor-tool integration process. Silicon nanowires (SiNWs) are used as piezoresistive sensing elements embedded on the four cantilevers of the sensor to measure the strain induced by the applied load. An integration scheme with new designed guide wire tip structure having two coils at the distal end is presented. Finite element modeling has been employed in the sensor design to find the maximum stress location in order to put the SiNWs at the high stress regions to obtain maximum output. A maximum applicable force of 5 mN is found from analytical modeling. The fabricated device has been characterized. The measured results showed good linearity to the applied force and no hysteresis was observed.

Beibei Han received her B.S. degree in information engineering from Shandong University, Weihai, China, in 2006, and the M.S. degree in mechanical engineering from Korea University of Technology and Education, Cheonan, South Korea, in 2008. She is currently working toward the Ph.D. degree in mechanical and aerospace engineering at Nanyang Technological University, Singapore. Her research interests include micro-/nano-electromechanical systems, micro tactile sensors for biomedical and robotics applications, characterization of silicon nano wires, haptic systems for medical applications.

84

Bio4Apps Poster Paper (8):

Triple-Band Implantable Antenna with Open-End Slots in Ground

Li-Jie Xu1, 2, Yong-Xin Guo1 and Wen Wu2

1. Department of Electrical and Computer Engineering, National University of Singapore, Singapore

2. Nanjing University of Science and Technology, Nanjing 210094, China

Biography of Presenting Author: Ms. Lijie Xu

Abstract

We present an implantable planar-inverted F antenna covering three bands, Medical Implant Communication Services (MICS) band at 402 MHz, Industrial, Scientific, and Medical (ISM) bands at 433 MHz and 2.45 GHz. The antenna occupies a compact size of 487.8 mm3 (19.8 mm × 19.4 mm × 1.27 mm), and is simulated in a one-layer skin model with thickness of 60 mm. The initial design of the implantable antenna has a Π-shape structure with two meandered strips to achieve dual band at both MICS band and ISM band. By adding open-end slots in the ground plane, three resonant frequencies are observed at MICS band, where the bandwidth can be broadened by tuning the length of the slots. The operating principle is analyzed and verified. The measured bandwidths are 52.6% at MICS band and 4.2% at ISM band, respectively. To evaluate the performance of the proposed antenna, both the three-dimensional far-field gain patterns and the coupling strength |S21| have been presented in this paper.

Lijie Xu received her B.S. degree in Nanjing University of Science and Technology, Nanjing, China, in 2009. She is currently working toward the Ph.D. degree in Microwave and electronic engineering at Nanjing University of Science and Technology. She is also an exchange student at National University of Singapore. Her research interests include implantable antennas based on PCB, CMOS and LTCC substrate for biomedical applications, low-pass and band-pass filters.

85

Bio4Apps Poster Paper (9):

Compact Dual-Band Antenna for

Implantable Devices

Changrong Liu1, 2, Yong-Xin Guo1,and Shaoqiu Xiao2

1. Department of Electrical and Computer Engineering, National University of Singapore, Singapore

2. University of Electronic Science and Technology, Chengdu, China

Biography of Presenting Author: Mr. Changrong Liu Abstract

A miniaturized dual-band implantable antenna is presented for medical communications service (MICS) (402 - 405 MHz) and industrial, scientific, and medical (ISM) (2.4 - 2.48 GHz) applications. Two spiral resonators coupled with each other were used to achieve a wide bandwidth at the lower band. The simulated and measured results are studied and compared for the antenna with tissue mimicking gels. Compared with traditional dual-band antennas, the proposed antenna is small in size and also covers the suitable wide bandwidth at both bands. The proposed antenna has dimensions of 16.5×16.5×2.54 mm3. The simulated bandwidths are 12.6% at MICS and 5.7% at ISM, and the measured bandwidths are found to be 13% at MICS, and 4.4% at ISM, respectively. -band implantable antenna is presented for medical communications service (MICS) (402 - 405 MHz) and industrial scientific and medical (ISM)

Changrong Liu received the B.E. and M.E. degrees from the University of Electronic Science and Technology of China (UESTC), Chengdu, in 2008 and 2011, respectively. He is currently working toward the Ph.D. degree at UESTC. From March 2010 to March 2011/August 2012 to August 2013, he was/is a visiting student in Department of Electrical and Computer Engineering, National University of Singapore, Singapore. His main research interests include LTCC-based millimeter-wave antenna design, circularly polarized antenna arrays, and small antenna design for implantable devices.

86

Bio4Apps Poster Paper (10):

MEMS based Optical Coherence Tomography Probe for Bioimaging

  Xiaojing Mu,1,2, Hongbin Yu2, Hanhua Feng3 and Julius Ming-Lin Tsai2

1. Department of Mechanical Engineering, National University of Singapore, Singapore

2. Institute of Microelectronics (IME), A*STAR, Singapore 3. Temasek Engineering School, Temasek Polytechnic, Singapore

Biography of Presenting Author: Mr. Xiaojing Mu

Abstract

A prototype of an Optical Coherence Tomography (OCT) bioimaging endoscopic probe utilizing a MEMS micromirror as the light beam manipulator has been developed. The MEMS micromirror and the silicon optical bench (SiOB) assembly is enclosed within a biocompatible, transparent and waterproof polycarbonate tube equipped with toroidal-lens for in vivo diagnostic applications. The effects of the curvatures of the mirror platform and the housing on the optical behavior of the OCT probe have been discussed. The toroidal-lens embedded catheter design is proposed to reduce the cylindrical lens effect induced by the cylindrical shape tube. The two-axis scanning micromirror is driven by four independent electrothermal bimorph actuators at a driving voltage of less than 2V to produce a tilt angle of 11°. High resolution OCT images of the skin tissue from the hind leg of a mouse can be obtained by integrating the MEMS micromirror probe with a commercially available OCT system.

Xiaojing Mu received the B.S. and M.S. degrees in the Department of Mechanical Engineering from Chongqing University (CQU), Chongqing, P.R China, in 2006 and 2008, respectively. He is currently a Ph.D student in Micro/ Nano System Initiative (MNSI) lab at National University of Singapore (NUS), Singapore and also an attached full-time research student with miniature medical device (MMD) group from the Institute of Microelectronics, Agency for Science, Technology and Research (A*STAR). His interest lies in optical MEMS and his current work focuses on the design and fabrication of optical micro devices for medical applications.

87

Bio4Apps Poster Paper (11):

Silicon Nanowires (SiNWs) Based NEMS Piezoresistive Mechanical

Sensors   

Songsong Zhang1, Liang Lou2, Woo-Tae Park3, Li Shiah Lim2, Wei Mong Tsang 2, Minkyu Je2 , and Chengkuo Lee1

1. Department of Mechanical Engineering, National University of Singapore, Singapore

2. Institute of Microelectronics (IME), A*STAR, Singapore 3. Department of Mechanical and Automotive Engineering, Seoul National University of

Science and Technology, Seoul, Korea

Biography of Presenting Author: Mr. Songsong Zhang

Abstract

Piezoresistive transduction is one of the earliest sensing mechanisms and has been widely adopted in many applications. Its rather straightforward electrical signal conversions simplify the interfacial circuitries during the system integrations. Compared with traditional metal materials, the superior piezoresistive effect on doped silicon and germanium has been well known and applied as sensing elements into microsystems since the 1950s. As driving by the progresses in semiconductor technology, trends of migration from microelectromechanical system (MEMS) to nanoelectromechanical system (NEMS) becomes inevitable. Nano-engineered structures have not only demonstrated their great scalabilities, but significant sensing capability improvements have also been reported based on various applications. In this conference, we summarize our recent research efforts on silicon nanowires (SiNWs) based NEMS mechanical sensors. Both device structures and fabrications are introduced. Information on measurement results verify sensitivity boosts and the device reliability for different applications.

Songsong Zhang received the B.Tech degree in the Department of Electrical Engineering from National University of Singapore (NUS), Singapore, in 2009. He is currently a Ph.D student in Centre for integrated Circuit Failure Analysis & Reliability (CICFAR) lab at Electrical &Computer

Engineering ， National University of Singapore (NUS), Singapore. His research interests focus on piezoresistive bio-medical MEMS sensors.

88

Bio4Apps Poster Paper (12):

Low-frequency Vibration-based Energy Harvester Using a

Piezoelectric Composite Beam Lokesh Dhakar1, 2, Huicong Liu2, F. E. H. Tay1, 3 and Chengkuo Lee 2

1NUS Graduate School for Integrative Sciences and Engineering, Singapore 2Department of Electrical and Computer Engineering, National University of Singapore

3Department of Mechanical Engineering, National University of Singapore

Biography of Presenting Author: Mr. Lokesh Dhakar

Abstract

A composite beam based piezoelectric energy harvester (EH) is designed and characterized which can be used to harvest energy with low frequency vibrations such as human motion, heartbeat, household equipment and structures such as buildings. This kind of EH is demonstrated to be 3.12 times and 1.32 times (at 0.1g) more efficient at output power generation than a standalone piezoelectric bimorph and piezoelectric bimorph with a proof mass at the free end, respectively. The resonant frequency of the EH is reduced from 275 Hz (for standalone bimorph) to 36 Hz by using the soft spring. With the aid of spring hardening effect, the operating bandwidth is increased from 5 Hz to 16.4 Hz.

Lokesh Dhakar received his B.E. (Hons.) in mechanical engineering from Birla Institute of Technology and Science, Pilani, India in 2010. He then worked as a design engineer in the industry. He is currently pursuing integrated PhD-MBA program jointly hosted by NUS Graduate School of Integrated Sciences and Engineering and NUS Business School. His research interests lies in energy harvesting mechanisms at nano/micro scale. He is also keenly interested in entrepreneurship.

89

Bio4Apps Poster Paper (13):

Development of Polymer-based Cantilever Electrodes for Neural

Interfacing Zhuolin Xiang12, Hao Wang12, Songsong Zhang1, Minkyu Je3, Wei Mong Tsang3,

Yong-Ping Xu1, Shih-Cheng Yen12,Nitish V.Thakor2, Chengkuo Lee12* 1Department of Electrical & Computer Eng., National University of Singapore, Singapore 2Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore,

Singapore 3Institute of Microelectronics, Agency for Science, Technology and Research (A*STAR),

Singapore

Biography of Presenting Author: Mr. Zhuolin Xiang Abstract

An innovative design and a simple method are demonstrated to fabricate a released SU-8 neural probe in this paper. Because of good biocompatibility and mechanical excellence of low Young’s modulus (less tissue damages) but relatively high stiffness (easier for insertions), we deployed SU-8 as the main material in current study. The probe only has a 15um space between electrodes and neural cell, which will ensure the signal acquisition. Fluidic testing shows the bonding quality. Penetration testing shows this probe could be inserted into the bio-gel and thus it is theoretically strong enough for tissue penetrations in vivo tests.

Zhuolin Xiang received his B.Eng. degree from the Department of Information and Electronics, Beijing Institute of Technology, Beijing, P.R China in 2011. He is currently a Ph.D student in Electrical and Computer Engineering, National University of Singapore. His research interests focus mainly on BioMEMs Devices for drug delivery and neural interfacing.

90

Bio4Apps Poster Paper (14):

Development of SU-8 Microneedles Integrated With Dissolvable Tips for

Transdermal Drug Delivery

Zhuolin Xiang1, Hao Wang1, Chengkuo Lee1*, Aakansha Pant2, Pastorin, Giorgia2§ 1Department of Electrical & Computer Eng., National University of Singapore, Singapore

2Department of Pharmacy, National University of Singapore, Singapore Correspondence: *elelc@nus.edu.sg;§phapg@nus.edu.sg

Biography of Presenting Author: Mr. Zhuolin Xiang Abstract

A unique process for making SU-8 microneedles integrated with dissolvable tips for transdermal drug delivery is presented in this paper. Previously, SU-8 microneedles array are usually fabricated with a PDMS mould, stainless steel mould or Si mould to get a ultra-sharp tips for easy insertion. These fabrication techniques rely on the excellent quality of the moulds, which are usually time consuming and expensive to manufacture. Here, we will demonstrate a new method to fabricate SU-8 microneedles. In order to overcome the barrier of stratum corneum, we use drawing lithography technology to integrate the SU-8 tubes with maltose tips. Shape maltose tips will lead the SU-8 tubes easily pass through the outer layer of the skin. After that, maltose will be dissolved in the body fluid and drugs can be delivered through the following SU-8 tubes.

d i l t bl t i t d f di l i ti

Zhuolin Xiang received his B.Eng. degree from the Department of Information and Electronics, Beijing Institute of Technology, Beijing, P.R China in 2011. He is currently a Ph.D student in Electrical and Computer Engineering, National University of Singapore. His research interests focus mainly on BioMEMs Devices for drug delivery and neural interfacing.

91

Bio4Apps Poster Paper (15):

Development of Patterned Vertically Grown Carbon Nanotubes Filters for

Mass Transportation

Wang Hao1, Zhuolin Xiang1,2, Chih-Fan Hu3, Chengkuo Lee1, Aakansha Pant2, Weileun Fang3, Giorgia Pastorin2

1Department of Electrical & Computer Eng., National University of Singapore, Singapore 2Department of Pharmacy, National University of Singapore, Singapore

3Department of Power Mechanical Engineering, National Tsing Hua University, Taiwan

Biography of Presenting Author: Mr. Hao Wang Abstract

A unique process for making patterned vertically grown Carbon Nanotubes (CNTs) filters for mass transportation is reported in this study. Previously, CNTs filter is made from a whole CNT forest without patterns. It is difficult to integrate it with other micro-fluidics. Here, vertically grown CNT bundles of 50 micrometer diameter and 50 micrometer height are assembled on SU-8 substrate with holes under CNT bundles. The CNT bundles are fixed on a SU-8 substrate just with parylene sidewall. Two PDMS layers are bond for tube connection and fluid test. The novel fabrication process realizes a thin film with patterned vertical CNT bundles as filters which allows ions to transport from one end to another end with the aid of electric filed.

and implantable trial, scientific, and medical (ISM) (2.4 - 2.48 GHz) li i C d i h di i l d l b d h

Hao Wang received his B.Eng. degree in School of Optoelectronic Information from University of Electronic Science and Technology of China in 2010. He is currently a research engineer at ECE, NUS and pursuing his M. Eng degree at the same department. His research interests are focused on nanoneedle devices for transdermal drug delivery.