Interferon-α-2b/peginterferon-α-2b
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Transcript of Interferon-α-2b/peginterferon-α-2b
Reactions 1037 - 5 Feb 2005
★ SInterferon-α-2b/peginterferon-α-2b
Pure red cell aplasia (first report with peginterferon-α-2b): case report
A 50-year-old female liver transplant recipient developedpure red cell aplasia during treatment with interferon-α-2b andpeginterferon-α-2b for recurrent hepatitis C virus infection.
The woman received interferon-α-2b 3 million units threetimes weekly for 4 weeks, followed by peginterferon-α-2b25 µg/week; her concomitant medication included sirolimus,tacrolimus and prednisone. After 5 months’ treatment, shedeveloped pancytopenia, with severe anaemia and liverenzyme elevation; a liver biopsy was consistent with allograftrejection.
Peginterferon-α-2b was discontinued and the woman’sleucopenia and thrombocytopenia resolved. However,transfusion-dependent anaemia persisted and, 3 months afterthe discontinuation of antiviral therapy, she had ahaemoglobin level of 2.9 g/dL, marked reticulocytopenia andan elevated serum erythropoietin level. A bone marrow biopsyrevealed 30% cellularity, significantly decreased erythroidprecursors and a significantly elevated myeloid:erythroid ratio(> 20:1); pure red cell aplasia was diagnosed. She was treatedwith IV immunoglobulins and, after 10 days, reticulocytosisand stabilisation of her haemoglobin level were observed. Heranaemia did not recur during > 10 months follow-up.
Author comment: "We conclude that this patient’s purered cell aplasia may have been triggered by interferon α, likelyassociated with the known complex immunological activitiesof interferon α that may lead to the de novo development ofautoimmunity."Arcasoy MO, et al. Pure red cell aplasia following pegylated interferon alphatreatment. American Journal of Medicine 117: 619-620, No. 8, 15 Oct 2004 -USA 800995109
» Editorial comment: A search of AdisBase, Medline and theWHO Adverse Drug Reactions database did not reveal anyprevious case reports of pure red cell aplasia associated withpeginterferon-α-2b.
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Reactions 5 Feb 2005 No. 10370114-9954/10/1037-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved