RESEARCH SYMPOSIUM 2018

INSTITUTE OF TRANSLATIONAL AND STRATIFIED MEDICINE (ITSMed)

We are delighted to welcome you to celebrate the opening of the Derriford Research Facility – the new, state-of-the-art headquarters of the University of Plymouth’s Institute of Translational and Stratified Medicine ITSMed.

Plymouth is steeped in a history of pioneering and discovery. To advance this journey today in the field of medical science, it is essential to cultivate powerful relationships and collaborations with like-minded peers, to successfully tackle health issues through high quality research.

This symposium brings together the scientific, medical and business communities, to grow a geographical hub of world-class expertise and research excellence in the South West for the benefit of patients, the public, and for a positive economic impact.

The day promises to deliver a rich programme of insight and discussion and we are particularly honoured to welcome our keynote presenters Professor Dame Pamela Shaw, Vice-President and Head of the Faculty of Medicine, Dentistry and Health at the University of Sheffield, and Dr Mark Fidock, Vice President, Precision Medicine Laboratories within the IMED Biotech Unit, AstraZeneca.

In addition to hearing of the University’s world-leading biomedical and clinical research from the academics directing our investigations, you also have the opportunity to network to a backdrop of research posters and take a tour of our new facility.

We would like to take this opportunity to thank all of the delegates, presenters and sponsors of this year’s symposium and wish you and intriguing and enjoyable visit.

Professor Oliver Hanemann, Director, ITSMed

CONTENTSWelcome 3

About ITSMed 4

Symposium Speakers 6

Programme 8

Exhibitors 10

WELCOME

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Translational research to develop new therapeutics, diagnostics, interventions and preventative approaches for patient and public benefit.ITSMed brings together scientists, clinicians and expertise from across the spectrum of scientific discovery, medical research and health technology, to conduct world-class laboratory and clinical research.

The Institute’s collaborative, interdisciplinary research environment and integrative ‘bench to bedside and back’ approach enables development of new therapeutics, diagnostics, interventions and approaches to prevent, detect and treat devastating diseases, enhance patient outcomes, and improve global healthcare.

The Institute hosts two major research groups, Biomedical Research Group and Clinical Trials and Population Studies Group, with combined facilities and resources that cluster researchers with recognised expertise from across the University of Plymouth’s Faculty of Medicine and Dentistry and beyond.

ITSMed is also home to the University of Plymouth’s internationally renowned Brain Tumour Research Centre of Excellence.

Our focus is on three core research themes of: Cancer; Infection, Immunity and Inflammation; and Clinical Neuroscience, facilitated by cross-cutting expertise in Diagnostics, Clinical Trials and Public Health research.

This translational research is facilitated by the University of Plymouth’s UK Clinical Research Collaboration (UKCRC) registered Peninsula Clinical Trials Unit (PenCTU), Medical Statistics and Systems Biology Centre teams.

Our research strengths were confirmed by the excellent results from our submission to the Research Excellence Framework (REF) 2014 which ranked us first in the UK for quality of research outputs in clinical medicine, above medical schools at Oxford and Cambridge.

To reflect our role as a research-led University with a major commitment to medicine and healthcare, we have built the Derriford Research Facility. Purposefully located next to our Medical and Dental Schools at Plymouth Science Park and neighbouring University Hospitals Plymouth NHS Trust, the DRF will enhance powerful collaborations between our research teams, clinicians, and biotech and pharmaceutical companies to accelerate progress and synergise expertise and resources.

This prestigious facility serves as the new headquarters for ITSMed, providing the high-level technology and laboratory space required to perpetuate our momentum and make a lasting positive impact on the medical landscape.

ABOUT ITSMed

4 5EXCEPTIONAL CLINICAL LEARNING • STRONG SOCIAL ENGAGEMENT • WORLD-CLASS RESEARCH www.plymouth.ac.uk/ITSMedEXCEPTIONAL CLINICAL LEARNING • STRONG SOCIAL ENGAGEMENT • WORLD-CLASS RESEARCH

Professor Oliver Hanemann Director, Institute of Translational and Stratified MedicineResearch lead, Brain Tumour Research Centre of Excellence

Professor Simon Rule Professor in Haematology

INFECTION, IMMUNITY AND INFLAMMATION

CANCER

UNIVERSITY OF PLYMOUTH

CLINICAL NEUROSCIENCE

Professor Jerry Roberts Deputy Vice-Chancellor, Research and Enterprise

Professor Ji-Liang Li Professor, Chair in Cancer Immunology

Dr Shouqing Luo Associate Professor (Reader) in Clinical Neurobiology

Dr Mat Upton Associate Professor in Medical Microbiology

Dr Edgar Kramer Professor of Neurodegenerative Diseases

Dr Camille Carroll Consultant Neurologist

SYMPOSIUM SPEAKERSKEYNOTE Professor Dame Pamela Shaw DBE MBBS MD FRCP FMedSci FAAN FANA FAAAS

Vice-President and Head of the Faculty of Medicine, Dentistry and Health, Sheffield University.

Director, Sheffield Institute for Translational NeuroscienceProfessor Shaw graduated in Medicine with 1st Class Honours from the University of Newcastle in 1979. She undertook her MRCP and Specialist Training in Neurology training in Newcastle. In 1988 she was awarded an MD with commendation for her work on the neurological complications of coronary bypass surgery. After an intermediate fellowship award from the Wellcome Trust, she was awarded a Wellcome Senior Fellowship in Clinical Science which she held from 1991 -2000. In 1997 she was appointed Professor of Neurological Medicine at the University of Newcastle and in 2000 was appointed as Professor of Neurology at the University of Sheffield.

KEYNOTE Dr Mark Fidock

Vice President, Precision Medicine Laboratories within the IMED Biotech Unit, AstraZeneca.

Drug development in the era of Precision Medicine Dr Fidock received his PhD from the University of East Anglia, UK in Molecular Pharmacology. He gained extensive experience of drug development whilst at Pfizer R&D UK, where he led Biomarker and Translational Medicine activities across multiple therapeutic areas. In 2013, Mark joined AstraZeneca appointed to the role of Head of Precision Medicine Laboratories, a multidisciplinary team developing companion diagnostic tests deployed across early and late phase clinical development in order to identify patients that are most likely to benefit from targeted medicines. Mark is an honorary senior lecturer at the University of Cambridge, UK.

Dr Michael Jarvis Associate Professor (Reader) in Virology and Immunology

6 7EXCEPTIONAL CLINICAL LEARNING • STRONG SOCIAL ENGAGEMENT • WORLD-CLASS RESEARCH www.plymouth.ac.uk/ITSMedEXCEPTIONAL CLINICAL LEARNING • STRONG SOCIAL ENGAGEMENT • WORLD-CLASS RESEARCH

PROGRAMME

09:00 - 09:30 ARRIVAL AND REGISTRATION

Morning Session09:00 - 09:50 WELCOME AND ITSMed OVERVIEW

Welcome: Professor Jerry Roberts, Deputy Vice-Chancellor, Research and Enterprise, University of Plymouth

ITSMed overview: Professor Oliver Hanemann, Director, ITSMed

09:50 - 10:30 Keynote speech

Professor Dame Pamela Shaw, Vice-President and Head of the Faculty of Medicine, Dentistry and Health, University of Sheffield

10:30 - 10:50 M&Ms: Merlin and Meningiomas

Professor Oliver Hanemann, Research lead, Brain Tumour Research Centre of Excellence

10:50 - 11.15 Notch signalling in tumour biology and response to therapeutic intervention

Professor Ji-Liang Li, Chair in Cancer Immunology, ITSMed

11:15 - 11:40 TEA AND COFFEE BREAK Including poster display and exhibitions

11:45 - 12:05 Simultaneously modulating autophagy and cell death to effectively tackle Huntington’s disease

Dr Shouqing Luo, Associate Professor (Reader) in Clinical Neurobiology, ITSMed

12:05 - 12:25 Etiology and treatment of Parkinson’s disease

Dr Edgar Kramer, Professor of Neurodegenerative Diseases, ITSMed

12:25 - 13:55 LUNCH, TOURS OF THE FACILITY, POSTER DISPLAY AND EXHIBITIONS

Afternoon Session14:00 - 14:40 Keynote speech

Dr Mark Fidock, Vice President, Precision Medicine Laboratories within the IMED Biotech Unit, AstraZeneca.

14:40 - 15:00 Novel antibiotics to meet the global health threat of antibiotic resistance

Dr Mat Upton, Associate Professor in Medical Microbiology, ITSMed

15:00 - 15:20 Herpesvirus-based vaccination strategies for targeting animal species involved in zoonotic transmission to man

Dr Michael Jarvis, Associate Professor (Reader) in Virology and Immunology, ITSMed

15:20 - 15:40 CREAM TEA AND COFFEE BREAK Including poster display and exhibitions

15:40 - 16:00 Lymphoma – chemotherapy-free treatment is becoming a reality

Professor Simon Rule, Professor in Haematology, ITSMed and University Hospitals Plymouth NHS Trust

16:00 - 16:20 A centre for Parkinson’s disease clinical trials

Dr Camille Carroll, Consultant Neurologist in Clinical Neuroscience, ITSMed and University Hospitals Plymouth NHS Trust

16:20 - 16:35 Closing summary

16:35 CLOSE: WINE AND CANAPÉS

All sessions will take place in Lecture Theatre 1 in the John Bull Building. Refreshments will be provided in the café area.

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EXHIBITORS NOTESBio-Techne empowers researchers in Life Sciences and Clinical Diagnostics by providing high-quality reagents, instruments, custom manufacturing, and testing services. Our family of brands creates a unique portfolio of products and services.

www.bio-techne.com

BMG LABTECH is a world leader in microplate reader instrumentation for Fluorescence, Fluorescence Polarisation, UV Vis Absorbance, Luminescence and Nephelometry.

www.bmglabtech.com

Test & Measurement, Fluid Handling & Biosciences.

www.coleparmer.co.uk

Experience the power of DNA.

www.eurofinsgenomics.eu

Leica Microsystems develops and manufactures microscopes and scientific instruments for the analysis of microstructures and nanostructures.

www.leica-microsystems.com

Merck is a science & technology company driven by a passion for research & discovery.

www.merckmillipore.com

Empowering cell research. Enabling cell therapy.

www.miltenyibiotec.com

New England Biolabs (NEB) produces and supplies molecular biology reagents for the life science industry. NEB offers the largest selection of enzymes for genomic research.

www.neb.uk.com

www.promega.co.uk

Your partner for equipment and consumables for medicine and science.

www.sarstedt.com

Excellence in Science.

www.shimadzu.co.uk

www.thermofisher.com

Certified British manufacturer and distributor of high quality laboratory equipment.

www.triplered.com

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